Moisturizing eyeshade for relieving eye fatigue and preparation method of moisturizing eyeshade

Abstract

The invention discloses a moisturizing eyeshade for relieving eye fatigue and a preparation method of the moisturizing eyeshade, and belongs to the technical field of eyeshade preparation. The eyeshade comprises an eyeshade body and elastic ear hooks, and the eyeshade body is sequentially provided with a moisturizing and heat insulation layer, a bionic tear layer, a self-heating layer and an outer cover layer from inside to outside. The moisture-preserving and heat-insulating layer is prepared by soaking cotton velvet non-woven fabric in moisture-preserving gel liquid and then compounding the cotton velvet non-woven fabric with a breathable film; the self-heating layer is prepared by paving a heating mixture on a breathable non-woven fabric and performing hot-pressing sealing by using a gas barrier film; the bionic tear layer is prepared from bionic tears and a non-woven fabric; the two sides of the bionic tear layer are tightly attached to the self-heating layer and the moisturizing and heat-insulating layer respectively, the eyeshade body and the elastic ear hooks are welded through hot pressing, the bionic tear takes rice chaff wax ester and phytosterol as a lipid phase, the lipid phase and an active concentrated solution are stirred and mixed to obtain lipidosome colostrum, and the lipidosome colostrum is processed through a membrane extruder to obtain the eyeshade. The prepared eyeshade has the effects of preserving moisture and relieving eye fatigue.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of eye mask preparation, and particularly relates to a moisturizing eye mask for relieving eye fatigue and a preparation method thereof. BACKGROUND

[0002] In modern society, with the popularity of electronic devices and the acceleration of work and life pace, the intensity of people's eyes increases significantly, and problems such as eye fatigue, dryness, acid swelling and the like have become a common health problem. The core causes of eye fatigue include: excessive evaporation of water caused by unstable tear film of the ocular surface, accumulation of metabolic products caused by long-term tension of ocular muscles, poor blood circulation around the eyes, and chronic damage to the ocular tissues caused by external stimuli such as blue light. In addition, factors such as air-conditioned environment and dry climate can further exacerbate the loss of ocular surface moisture, leading to discomfort such as dry eyes and foreign body sensation, forming a vicious cycle of "fatigue-dryness-more fatigue".

[0003] To alleviate the above problems, eye masks, as a convenient eye care tool, are widely used. Traditional moisturizing eye masks achieve moisturizing through the following ways: ① using airtight fabric (such as polyester fiber, spandex) to reduce air flow around the eyes and reduce the evaporation speed of tears; ② adding ordinary moisturizing agents (such as glycerol, propylene glycol) to the inner layer of the eye mask to absorb moisture through the skin keratin layer. However, such designs have fundamental defects: passive water locking cannot actively supplement the ocular surface moisture, and the effect is weak for people with insufficient tear secretion or short tear film break-up time (such as dry eye patients); small molecule moisturizing agents such as glycerol are prone to volatilization due to temperature rise or prolonged wearing time, and the moisturizing duration is usually not more than 30 minutes, and the concentration fluctuation may cause the imbalance of the ocular surface osmotic pressure, leading to a stinging sensation; although the airtight fabric reduces evaporation, it can cause the temperature around the eyes to rise (the temperature of some products can reach above 40℃), which in turn accelerates the loss of skin moisture and increases the hot and stuffy feeling around the eyes, reducing the wearing comfort.

[0004] Therefore, the present application develops a moisturizing eye mask for relieving eye fatigue and a preparation method thereof to solve the technical problems in the prior art that the eye mask lacks effective moisturizing function and targeted effect of relieving eye fatigue, lacks targeted bioactive ingredients, cannot improve eye metabolism, and has short action duration and cannot form long-term intervention. SUMMARY

[0005] The purpose of the present application is to provide a moisturizing eye mask for relieving eye fatigue and a preparation method thereof to solve the technical problems in the prior art that the eye mask lacks effective moisturizing function and targeted effect of relieving eye fatigue, lacks targeted bioactive ingredients, cannot improve eye metabolism, and has short action duration and cannot form long-term intervention.

[0006] In order to achieve the above purpose, the present application adopts the following technical solutions: The moisturizing eye mask for relieving eye fatigue comprises an eye mask body and an elastic ear hook connected with the eye mask body, and the eye mask body is sequentially provided with a moisturizing and heat-insulating layer, a biomimetic tear layer, a self-heating layer and an outer cover layer from inside to outside. The moisturizing and heat-insulating layer is prepared by dipping cotton non-woven fabric in a moisturizing gel liquid and then compounding the cotton non-woven fabric with a breathable film. The self-heating layer is prepared by laying a heating mixture on a breathable non-woven fabric and then hot-pressing and sealing the breathable non-woven fabric with a gas-barrier film. The biomimetic tear layer is prepared from biomimetic tears and non-woven fabric. The biomimetic tear layer is tightly attached to the self-heating layer and the moisturizing and heat-insulating layer on both sides, and the eye mask body and the elastic ear hook are welded by hot pressing.

[0007] The preparation method of the moisturizing and heat-insulating layer comprises the following steps: S1. Dissolve glycerol, trehalose, tremella polysaccharide, dipotassium glycyrrhizinate, nicotinamide and sialic acid in water and stir until completely dissolved to obtain an essence liquid. Add sodium hyaluronate to the essence liquid and stir to swell. Then add collagen, asiaticoside, bovine growth factor and lutein to the gel base and stir to obtain a moisturizing gel liquid. S2. Dip the cotton non-woven fabric in the moisturizing gel liquid, remove the excess liquid, and then compound the cotton non-woven fabric with a breathable film to obtain the moisturizing and heat-insulating layer.

[0008] Preferably, the mass ratio of glycerol, trehalose, tremella polysaccharide, dipotassium glycyrrhizinate, nicotinamide, sialic acid, sodium hyaluronate, collagen, asiaticoside and water in S1 is (7-10):(3-5):4:(0.5-0.8):(2-4):(0.8-1):(1-1.2):(2-4):(0.5-0.7):(2-3):(0.05-0.07):100.

[0009] The preparation method of the self-heating layer comprises the following steps: H1. Stir iron powder, activated carbon, vermiculite, water and sodium chloride in a sealed stirring pot to obtain a heating mixture. H2. Lay the heating mixture on a breathable non-woven fabric, hot-press and seal the breathable non-woven fabric with a gas-barrier film to obtain a heating bag. Punch holes on one side of the gas-barrier film to obtain the self-heating layer.

[0010] Preferably, the mass ratio of iron powder, activated carbon, vermiculite, water and sodium chloride in H1 is 100:(10-15):(10-20):(30-40):(5-8).

[0011] Preferably, the gas-barrier film in H2 is a PET / PE composite film; the pore size of the punched holes is 0.10mm-0.25mm; and the hole density is 80-200 holes / square centimeter.

[0012] The preparation method of the biomimetic tear layer comprises the following steps: M1, heat and stir the rice bran wax ester and phytosterol, mix, high-pressure homogenization, to obtain a lipid phase; M2, add sodium chloride, potassium chloride, lactoferrin, adenosine triphosphate-magnesium ion chelate and nano-sized beta-nicotinamide mononucleotide into the phosphate buffer, stir and dissolve, rotary evaporation, to obtain an active concentrate; stir and mix the lipid phase and the active concentrate, to obtain a liposome colostrum; pass the liposome colostrum through a membrane extruder, filter three times through a membrane with a pore size of 100 nm, to obtain the biomimetic tear fluid; M3, soak the non-woven fabric, dry, immerse in the liposome colostrum, take out, squeeze off the excess liposome colostrum, to obtain the biomimetic tear fluid loaded non-woven fabric; place the biomimetic tear fluid loaded non-woven fabric at a negative ion generator, to obtain the biomimetic tear layer.

[0013] Preferably, the temperature of heating in M1 is 70-75℃, the heating time is 30-40min, and the phytosterol is a mixture of beta-sitosterol, stigmasterol and campesterol in a mass ratio of 1: (1-2): 1.

[0014] Preferably, the temperature of stirring in M2 is 40-42℃, the mass ratio of sodium chloride, potassium chloride, lactoferrin, adenosine triphosphate-magnesium ion chelate, nano-sized beta-nicotinamide mononucleotide and phosphate buffer is (8-8.3): (1-1.2): 5: (0.5-0.6): (0.05-0.06): 1000; the vacuum degree of rotary evaporation is 0.08-0.1MPa, the temperature of rotary evaporation is 40-45℃, and the concentration end point of rotary evaporation is 10-20% of the original volume.

[0015] Preferably, the immersion time in M3 is 30-60min, and the time of placing at the negative ion generator is 10-15min.

[0016] The preparation method of the moisturizing eye mask for relieving eye fatigue comprises the following steps: (1) stack the moisture insulation layer, the biomimetic tear layer, the self-heating layer and the outer cover layer from inside to outside in sequence, so that the four-layer structure is tightly attached, to obtain an eye mask body; (2) connect the eye mask body and the elastic ear hook by ultrasonic welding, to obtain the moisturizing eye mask for relieving eye fatigue.

[0017] Further, the skin-facing side of the moisture insulation layer in step (1) is the inner layer; and the punched film of the self-heating layer faces the outer side.

[0018] As described above, due to the adoption of the above technical solutions, the present application has the following beneficial effects: 1. This invention utilizes three core functions: moisturizing and water-locking, gentle heat therapy, and biomimetic tear film to lubricate the eyes. The heat therapy promotes blood circulation around the eyes to relax muscles, the moisturizing layer continuously replenishes moisture to relieve dry skin, and the biomimetic tear film layer simulates the structure of natural tears to provide lasting hydration to the surface of the eyeball. The synergistic effect of these three functions provides a more comprehensive and in-depth relief effect than single-function eye masks, effectively relieving dry eyes and fatigue. In addition, the self-heating layer is sealed with an air-barrier PET / PE composite film, and the pore size and pore density are precisely controlled to stably control the heating rate and temperature, avoiding the problem of local overheating and burning of the skin around the eyes. At the same time, the biomimetic tear film and moisturizing gel are mainly composed of natural extracts (Tremella fuciformis polysaccharide, Centella asiatica extract) and mild active ingredients (niacinamide, sodium hyaluronate), reducing the risk of allergies or discomfort to the skin around the eyes.

[0019] 2. This invention optimizes the selection and proportion of ingredients in the moisturizing gel liquid. Glycerin serves as a basic moisturizer, quickly replenishing skin moisture. Trehalose and sodium hyaluronate work synergistically to form a water-locking film, reducing moisture evaporation. Tremella polysaccharide and collagen have both moisturizing and nourishing effects, improving the elasticity of the skin around the eyes. Niacinamide and Centella asiatica extract soothe the skin, reducing redness or sensitivity caused by dryness. The combined effect of these multiple ingredients achieves a "hydrating-locking-nourishing-soothing" moisturizing effect. Furthermore, the thick non-woven fabric soaked in essence forms a good physical heat insulation layer.

[0020] 3. This invention achieves physiological repair and fatigue relief of the ocular surface by mimicking the structure of natural tears and precisely replenishing active substances through a biomimetic tear film. The outer layer of natural tears is a lipid layer, which prevents water evaporation. The lipid phase of the biomimetic tear film mimics this structure. The waxy structure of rice bran wax esters forms a dense film, and phytosterols enhance the stability of the lipid membrane, allowing it to fuse with the natural tear film on the ocular surface, reducing tear evaporation and relieving dry eyes. Simultaneously, the liposomes treated with a 100nm membrane have uniform particle size, easily contacting the ocular surface and slowly releasing their contents, avoiding irritation. Furthermore, the sodium chloride and potassium chloride in the active concentrate mimic the electrolyte components in tears, maintaining the ocular surface osmotic pressure consistent with that of natural tears, preventing ocular cell damage caused by osmotic pressure imbalance, and relieving dryness and stinging caused by abnormal tear composition.

[0021] 4. This invention enhances the anti-fatigue effect of the eye mask by adding active substances to biomimetic tears. Lactoferrin, in particular, has antibacterial and anti-inflammatory effects, inhibiting the growth of harmful bacteria on the ocular surface, reducing ocular inflammation, and alleviating fatigue caused by inflammation. Adenosine triphosphate-magnesium ion chelate (ATP-magnesium) is a key substance in cellular energy metabolism, directly providing energy to eye muscle cells, improving eye muscle energy depletion caused by prolonged eye use, and relieving soreness and fatigue. Nano-sized β-nicotinamide mononucleotide (NMN) is a precursor to NAD+. +The precursor can promote the energy metabolism and antioxidant capacity of eye cells, reduce the damage of free radicals to ocular surface cells, and delay the accumulation of eye fatigue. In addition, the pore structure of the non-woven fabric can adsorb and store the biomimetic tears, and release them continuously through slow penetration; the negative ion treatment can enhance the activity of the liposomes, improve the bioavailability of the active substances, and achieve long-acting relief effect. BRIEF DESCRIPTION OF DRAWINGS

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.

[0023] Fig. 1 is the front view of the moisturizing eye mask for relieving eye fatigue of the present application; Fig. 2 is a schematic view of the ear-hanging of the moisturizing eye mask for relieving eye fatigue of the present application when it is not unfolded; Fig. 3 is a cross-sectional view of the body structure of the moisturizing eye mask for relieving eye fatigue of the present application.

[0024] Reference signs: 1. eye mask body, 2. elastic ear-hanging, 3. heating bag, 4. welding position, 1-1. moisturizing and heat-insulating layer, 1-2. biomimetic tear layer, 1-3. self-heating layer, 1-4. outer cover layer. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0026] Example 1: Reference Figs. 1-3As shown, the moisturizing eye mask for relieving eye fatigue of the embodiment comprises an eye mask body 1 and an ear hook 2 connected with the eye mask body, and the eye mask body is sequentially provided with a moisturizing and heat-insulating layer 1-1, a biomimetic tear layer 1-2, a self-heating layer 1-3 and an outer cover layer 1-4 from inside to outside. The moisturizing and heat-insulating layer 1-1 is prepared by soaking cotton non-woven fabric in a moisturizing gel liquid and then being compounded with a breathable film; the self-heating layer 1-3 is prepared by punching a heating bag 3; the biomimetic tear layer 1-2 is prepared by biomimetic tears and non-woven fabric; the moisturizing and heat-insulating layer 1-1 is the inner layer facing the skin side; the two sides of the biomimetic tear layer 1-2 are tightly attached to the self-heating layer 1-3 and the moisturizing and heat-insulating layer 1-1, respectively; the eye mask body and the elastic ear hook are welded by hot pressing to form a welding position 4.

[0027] Embodiment 2 The embodiment discloses a preparation method of a moisturizing eye mask for relieving eye fatigue, which comprises the following steps: (1) sequentially stack the moisturizing and heat-insulating layer, the biomimetic tear layer, the self-heating layer and the outer cover layer from inside to outside to make the four layers tightly attached to obtain an eye mask body; wherein the moisturizing and heat-insulating layer is the inner layer facing the skin side; and the punched film of the self-heating layer faces the outer side.

[0028] (2) connect the eye mask body and the elastic ear hook by ultrasonic welding to obtain the moisturizing eye mask for relieving eye fatigue.

[0029] The preparation method of the moisturizing and heat-insulating layer comprises the following steps: S1, dissolve 7-10 g of glycerol, 3-5 g of trehalose, 4 g of tremella polysaccharide, 0.5-0.8 g of dipotassium glycyrrhizinate, 2-4 g of nicotinamide and 0.8-1 g of sialic acid in 100 g of water, stir until completely dissolved to obtain an essence liquid; add 1-1.2 g of sodium hyaluronate to the essence liquid, stir to swell, then add 2-4 g of collagen, 0.5-0.7 g of asiaticoside, 2-3 g of bovine growth factor and 0.05-0.07 g of lutein to the gel base, stir to obtain a moisturizing gel liquid; S2, soak the cotton non-woven fabric in the moisturizing gel liquid, remove the excess liquid after taking it out, and then compound it with a breathable film to obtain the moisturizing and heat-insulating layer.

[0030] The preparation method of the self-heating layer comprises the following steps: H1, stir 100 g of iron powder, 10-15 g of activated carbon, 10-20 g of vermiculite, 30-40 g of water and 5-8 g of sodium chloride in a sealed stirring pot to obtain a heating mixture; H2, place the heating mixture on a breathable non-woven fabric, seal it by hot pressing with a PET / PE composite film to obtain a heating bag, punch holes on one side of the gas barrier film, the hole diameter is 0.10 mm-0.25 mm, and the hole density is 80-200 holes per square centimeter to obtain the self-heating layer.

[0031] The preparation method of the biomimetic tear layer comprises the following steps: M1, heat the rice bran wax ester and phytosterol, the heating temperature is 70℃, the heating time is 30-40min, stir and mix, high pressure homogenization, obtain the lipid phase, wherein the phytosterol is beta-sitosterol, stigmasterol and campesterol mixed according to the mass ratio of 1:1:1; M2, add 8g of sodium chloride, 1g of potassium chloride, 5g of lactoferrin, 0.5g of adenosine triphosphate-magnesium ion chelate and 0.05g of nano beta-nicotinamide mononucleotide into 1000g of phosphate buffer, stir and dissolve, the stirring temperature is 40℃, rotary evaporation, the vacuum degree of rotary evaporation is 0.08MPa, the temperature of rotary evaporation is 40℃, the concentration end point of rotary evaporation is 10% of the original volume, obtain the active concentrate; stir and mix the lipid phase and the active concentrate, obtain the liposome colostrum; pass the liposome colostrum through the membrane extruder, filter three times through the membrane with a pore size of 100nm, obtain the biomimetic tear fluid; M3, soak the non-woven fabric, dry, immerse in the liposome colostrum, the immersion time is 30min, take out, squeeze the excess liposome colostrum, obtain the biomimetic tear fluid loaded non-woven fabric; place the biomimetic tear fluid loaded non-woven fabric in the negative ion generator for 10min, obtain the biomimetic tear layer.

[0032] Example 3: The embodiment discloses a preparation method of a moisturizing eye mask for relieving eye fatigue, comprising the following steps: (1) stack the moisturizing and heat-insulating layer, the biomimetic tear layer, the self-heating layer and the outer cover layer from inside to outside in sequence, so that the four layers are tightly attached, to obtain an eye mask body; wherein the skin side of the moisturizing and heat-insulating layer is the inner layer; the punched film of the self-heating layer faces outward.

[0033] (2) then connect the eye mask body and the elastic ear hook by ultrasonic welding, to obtain the moisturizing eye mask for relieving eye fatigue.

[0034] The preparation method of the moisturizing and heat-insulating layer comprises the following steps: S1, dissolve 7g of glycerol, 3g of trehalose, 4g of tremella polysaccharide, 0.5g of dipotassium glycyrrhizinate, 2g of nicotinamide and 0.8g of sialic acid in 100g of water, stir until completely dissolved, to obtain an essence liquid; add 1g of sodium hyaluronate to the essence liquid, stir and swell, then add 2g of collagen, 0.5g of asiaticoside, 2g of bovine growth factor and 0.05g of lutein to the gel base, stir, to obtain a moisturizing gel liquid; S2, soak the cotton non-woven fabric in the moisturizing gel liquid, remove the excess liquid after taking it out, and composite with the breathable film, to obtain the moisturizing and heat-insulating layer.

[0035] The preparation method of the self-heating layer comprises the following steps: H1, 100g iron powder, 10g activated carbon, 10g vermiculite, 30g water and 5g sodium chloride are stirred in a sealed stirring pot to obtain a heating mixture; H2, the heating mixture is laid on a breathable non-woven fabric, sealed with PET / PE composite film hot pressing to obtain a heating bag, and the side of the gas barrier film is punched with a pore size of 0.10mm and a pore density of 80 holes per square centimeter to obtain the self-heating layer.

[0036] The preparation method of the biomimetic tear layer comprises the following steps: M1, rice bran wax ester and phytosterol are heated at a temperature of 73℃ for 33min, and then stirred and mixed, and high-pressure homogenization is performed to obtain a lipid phase, wherein the phytosterol is a mixture of beta-sitosterol, stigmasterol and campesterol in a mass ratio of 1:1.2:1; M2, 8.1g of sodium chloride, 1.1g of potassium chloride, 5g of lactoferrin, 0.54g of adenosine triphosphate-magnesium ion chelate and 0.054g of nano beta-nicotinamide mononucleotide are added to 1000g of phosphate buffer, stirred and dissolved, stirred at a temperature of 41℃, rotary evaporated at a vacuum degree of 0.09MPa, a rotary evaporation temperature of 43℃, and a rotary evaporation concentration end point of 13% of the original volume to obtain an active concentrate; the lipid phase and the active concentrate are stirred and mixed to obtain a liposome colostrum; the liposome colostrum is filtered through a membrane extruder three times through a membrane with a pore size of 100nm to obtain a biomimetic tear; M3, the non-woven fabric is soaked, dried, immersed in the liposome colostrum for 40min, taken out, and the excess liposome colostrum is squeezed out to obtain a biomimetic tear-loaded non-woven fabric; the biomimetic tear-loaded non-woven fabric is placed in a negative ion generator for 13min to obtain a biomimetic tear layer.

[0037] Example 4: The preparation method of the moisturizing eye mask for relieving eye fatigue comprises the following steps: (1) The moisturizing and heat-insulating layer, the biomimetic tear layer, the self-heating layer and the outer cover layer are stacked from inside to outside to make the four-layer structure tightly adhere to obtain an eye mask body; wherein the skin side of the moisturizing and heat-insulating layer is the inner layer; the punched film of the self-heating layer faces the outer side.

[0038] (2) The eye mask body is connected with the elastic ear hook through ultrasonic welding to obtain the moisturizing eye mask for relieving eye fatigue.

[0039] The preparation method of the moisturizing and heat-insulating layer comprises the following steps: S1, 9g glycerol, 4g trehalose, 4g tremella polysaccharide, 0.6g glycyrrhizic acid dipotassium, 3g nicotinamide and 0.9g sialic acid are dissolved in 100g water, stirred until completely dissolved, to obtain an essence; 1.1g sodium hyaluronate is added to the essence, stirred and swelled, then 3g collagen, 0.6g asiaticoside, 2.5g bovine growth factor and 0.06g lutein are added to the gel base, stirred, to obtain a moisturizing gel; S2, the cotton non-woven fabric is soaked in the moisturizing gel, after taking out, the excess liquid is removed, and the breathable film is compounded to obtain a moisturizing and heat-insulating layer.

[0040] The preparation method of the self-heating layer comprises the following steps: H1, 100g iron powder, 13g activated carbon, 15g vermiculite, 35g water and 7g sodium chloride are stirred in a sealed stirring pot to obtain a heating mixture; H2, the heating mixture is laid on the breathable non-woven fabric, and the PET / PE composite film is hot-pressed and sealed to obtain a heating bag; the side of the gas barrier film is punched, the pore size of the punched holes is 0.18mm, and the hole density is 150 holes per square centimeter, to obtain a self-heating layer.

[0041] The preparation method of the biomimetic tear layer comprises the following steps: M1, the rice bran wax ester and the phytosterol are heated, the heating temperature is 73℃, the heating time is 30-40min, and the mixture is stirred and mixed, and then high-pressure homogenization is performed to obtain a lipid phase, wherein the phytosterol is a mixture of beta-sitosterol, stigmasterol and campesterol in a mass ratio of 1:1.8:1; M2, 8.2g sodium chloride, 1.2g potassium chloride, 5g lactoferrin, 0.58g adenosine triphosphate-magnesium ion chelate and 0.058g nano-sized beta-nicotinamide mononucleotide are added to 1000g phosphate buffer, stirred and dissolved, the stirring temperature is 42℃, rotary evaporation is performed, the vacuum degree of rotary evaporation is 0.1MPa, the rotary evaporation temperature is 44℃, and the rotary evaporation concentration end point is 18% of the original volume, to obtain an active concentrate; the lipid phase and the active concentrate are stirred and mixed to obtain a liposome colostrum; the liposome colostrum is filtered through a membrane extruder three times through a membrane with a pore size of 100nm to obtain a biomimetic tear; M3, the non-woven fabric is soaked, dried, immersed in the liposome colostrum for 50min, taken out, and the excess liposome colostrum is squeezed out to obtain a biomimetic tear-loaded non-woven fabric; the biomimetic tear-loaded non-woven fabric is placed in a negative ion generator for 14min to obtain a biomimetic tear layer.

[0042] Example 5: The embodiment discloses a preparation method of a moisturizing eye mask for relieving eye fatigue, which comprises the following steps: (1) The moisturizing and heat-insulating layer, the biomimetic tear fluid layer, the self-heating layer and the outer cover layer are stacked from inside to outside in sequence, so that the four-layer structure is tightly attached to obtain the eye mask body; wherein the moisturizing and heat-insulating layer is on the skin side, that is, the inner layer; the punched film of the self-heating layer faces the outside.

[0043] (2) The eye mask body is connected with the elastic ear hook through ultrasonic welding to obtain the moisturizing eye mask for relieving eye fatigue.

[0044] The preparation method of the moisturizing and heat-insulating layer comprises the following steps: S1, 10g of glycerol, 5g of trehalose, 4g of tremella polysaccharide, 0.8g of potassium glycyrrhizinate, 4g of nicotinamide and 1g of sialic acid are dissolved in 100g of water, and stirred until completely dissolved to obtain an essence liquid; 1.2g of sodium hyaluronate is added to the essence liquid, and stirred to swell, then 4g of collagen, 0.7g of asiaticoside, 3g of bovine growth factor and 0.07g of lutein are added to the gel base, and stirred to obtain a moisturizing gel liquid; S2, the cotton non-woven fabric is soaked in the moisturizing gel liquid, after taking out, the excess liquid is removed, and the breathable film is compounded to obtain the moisturizing and heat-insulating layer.

[0045] The preparation method of the self-heating layer comprises the following steps: H1, 100g of iron powder, 15g of activated carbon, 20g of vermiculite, 40g of water and 8g of sodium chloride are stirred in a sealed stirring pot to obtain a heating mixture; H2, the heating mixture is laid on the breathable non-woven fabric, and sealed by hot pressing with a PET / PE composite film to obtain a heating bag, and the side of the gas barrier film is punched with a hole diameter of 0.25mm and a hole density of 200 holes per square centimeter to obtain the self-heating layer.

[0046] The preparation method of the biomimetic tear fluid layer comprises the following steps: M1, the rice bran wax ester and the phytosterol are heated, the heating temperature is 75℃, the heating time is 40min, and the mixture is stirred and homogenized under high pressure to obtain a lipid phase, wherein the phytosterol is a mixture of β-sitosterol, stigmasterol and campesterol in a mass ratio of 1:2:1; M2, 8.3g of sodium chloride, 1.2g of potassium chloride, 5g of lactoferrin, 0.6g of adenosine triphosphate-magnesium ion chelate and 0.06g of nano β-nicotinamide mononucleotide are added to 1000g of phosphate buffer, stirred and dissolved, the stirring temperature is 42℃, rotary evaporation is performed, the vacuum degree of rotary evaporation is 0.1MPa, the rotary evaporation temperature is 45℃, and the rotary evaporation concentration end point is 20% of the original volume to obtain an active concentrate; the lipid phase and the active concentrate are stirred and mixed to obtain a liposome colostrum; the liposome colostrum is filtered through a membrane extruder three times through a membrane with a pore size of 100nm to obtain the biomimetic tear fluid. M3, soak the non-woven fabric, dry, immerse in the liposome colostrum, the immersion time is 60 min, take out, squeeze the excess liposome colostrum, obtain the biomimetic tear liquid loaded non-woven fabric; place the biomimetic tear liquid loaded non-woven fabric at the place of negative ion generator for 15 min, obtain the biomimetic tear liquid layer.

[0047] Comparative Example 1: The present comparative example discloses a preparation method of a moisturizing eye mask for relieving eye fatigue, comprising the following steps: (1) stack the moisturizing and heat-insulating layer, the biomimetic tear liquid layer, the self-heating layer and the outer cover layer from inside to outside in order, so that the four layers are tightly attached to obtain an eye mask body; wherein the skin-facing side of the moisturizing and heat-insulating layer is the inner layer; the punched film of the self-heating layer faces outward.

[0048] (2) then connect the eye mask body and the elastic ear hook by ultrasonic welding to obtain the moisturizing eye mask for relieving eye fatigue.

[0049] The preparation method of the moisturizing and heat-insulating layer comprises the following steps: S1, dissolve 10 g of glycerol, 5 g of trehalose, 4 g of tremella polysaccharide, 0.8 g of potassium glycyrrhizinate, 4 g of nicotinamide and 1 g of sialic acid in 100 g of water, stir until completely dissolved to obtain an essence liquid; add 1.2 g of sodium hyaluronate to the essence liquid, stir to swell, then add 4 g of collagen, 0.7 g of asiaticoside, 3 g of bovine growth factor and 0.07 g of lutein to the gel base, stir to obtain a moisturizing gel liquid; S2, soak the cotton non-woven fabric in the moisturizing gel liquid, remove the excess liquid after taking it out, and compound it with the breathable film to obtain the moisturizing and heat-insulating layer.

[0050] The preparation method of the self-heating layer comprises the following steps: H1, stir 100 g of iron powder, 15 g of activated carbon, 20 g of vermiculite, 40 g of water and 8 g of sodium chloride in a sealed stirring pot to obtain a heating mixture; H2, lay the heating mixture on the breathable non-woven fabric, heat seal with PET / PE composite film to obtain a heating bag, punch holes on one side of the gas barrier film, the hole diameter is 0.25 mm, the hole density is 200 holes per square centimeter, to obtain the self-heating layer.

[0051] The preparation method of the biomimetic tear liquid layer comprises the following steps: M1, heat the rice bran wax ester and phytosterol, the heating temperature is 75℃, the heating time is 40 min, stir and mix, high-pressure homogenization to obtain a lipid phase, wherein the phytosterol is a mixture of β-sitosterol, stigmasterol and campesterol in a mass ratio of 1:2:1. M2, 8.3 g of sodium chloride, 1.2 g of potassium chloride, 0.6 g of adenosine triphosphate-magnesium ion chelate and 0.06 g of nano-sized β-nicotinamide mononucleotide were added into 1000 g of phosphate buffer, stirred and dissolved, the stirring temperature was 42℃, rotary evaporation was performed, the vacuum degree of rotary evaporation was 0.1 MPa, the temperature of rotary evaporation was 45℃, and the concentration end point of rotary evaporation was 20% of the original volume, to obtain an active concentrate; the lipid phase and the active concentrate were stirred and mixed to obtain a liposome colostrum; the liposome colostrum was filtered through a membrane with a pore size of 100 nm for three times by a membrane extruder to obtain a biomimetic tear fluid; M3, the non-woven fabric was soaked, dried, immersed in the liposome colostrum for 60 min, taken out, and squeezed to remove excess liposome colostrum, to obtain a biomimetic tear fluid loaded non-woven fabric; the biomimetic tear fluid loaded non-woven fabric was placed in a negative ion generator for 15 min to obtain a biomimetic tear fluid layer.

[0052] Comparative Example 1 and Example 5 were compared, and in the process of preparing the moisturizing eye mask for relieving eye fatigue, no lactoferrin was added in Comparative Example 1, and other conditions were unchanged.

[0053] Comparative Example 2: Comparative Example 2 and Example 5 were compared, and in the process of preparing the moisturizing eye mask for relieving eye fatigue, non-woven fabric was used instead of the moisture insulation layer in Comparative Example 2, and other conditions were unchanged.

[0054] Comparative Example 3 Comparative Example 3 and Example 5 were compared, and in the process of preparing the moisturizing eye mask for relieving eye fatigue, no sodium chloride and potassium chloride were added in Comparative Example 3, and other conditions were unchanged.

[0055] Comparative Example 4 Comparative Example 4 and Example 5 were compared, and in the process of preparing the moisturizing eye mask for relieving eye fatigue, no adenosine triphosphate-magnesium ion chelate was added in Comparative Example 4, and other conditions were unchanged.

[0056] Comparative Example 5 Comparative Example 5 and Example 2 were compared, and in the process of preparing the moisturizing eye mask for relieving eye fatigue, no nano-sized β-nicotinamide mononucleotide was added in Comparative Example 6, and other conditions were unchanged.

[0057] Experimental Example: The moisturizing eye masks for relieving eye fatigue prepared in Examples 2-5 and Comparative Examples 1-5 were subjected to the following performance tests.

[0058] I. Moisturizing efficacy evaluation Select 60 eligible subjects (age 22-45 years old) to participate in the test, the temperature of the test environment is 20-24℃, the relative humidity is 45-55%, before the test, the subjects are uniformly washed with water in the test area (forehead and eye area), sit still for 30 min in a constant temperature and humidity environment, the subjects are randomly divided into 12 groups of equal number, the samples prepared by the examples and the comparative examples are used in the groups, during the test, the test area of the subjects does not use other eye care products, and activities such as eating, drinking water, fighting and the like that can easily cause strong changes in skin moisture are prohibited. 1, 2, 4h after the subjects use the samples, the skin moisture content of the subjects is measured by using a skin moisture content tester and a moisture loss amount tester, the median is taken, and the test results are shown in Table 1:

[0059] According to the moisturizing efficacy evaluation results in Table 1, it can be seen that the eye mask for relieving eye fatigue prepared by examples 2-5 has good moisturizing efficacy, and from the comparison of comparative examples 1-5 and examples 2-5, it can be seen that the addition of sodium chloride, a moisture barrier layer, potassium chloride, lactoferrin, adenosine triphosphate-magnesium ion chelate and nano β-nicotinamide mononucleotide can help improve the moisturizing efficacy of the eye mask.

[0060] II. Evaluation of fatigue relief efficacy Select 60 eligible subjects (age 22-45 years old) to participate in the test, with a daily screen use habit of ≥6 hours, corrected visual acuity ≥0.8 (allowing to wear frame glasses), baseline period visual fatigue symptom scale (VFS-C) total score ≥8 points (full score 20 points), to ensure the presence of quantifiable fatigue state, the temperature of the test environment is 20-24℃, the relative humidity is 45-55%, the exclusion criteria covers four groups of people: patients with eye diseases: including glaucoma, active conjunctivitis and other organic lesions; drug interference objects: those who have used anti-fatigue drugs or eye treatment drugs within the last 24 hours. The visual fatigue symptom scale (VFS-C) score standard is shown in Table 2:

[0061] The visual fatigue symptoms of the subjects before and after wearing the eye mask for 2h are evaluated, the median is taken, and the test results are shown in Table 3:

[0062] According to the fatigue alleviation efficacy evaluation results in Table 3, it can be seen that the eye fatigue alleviating moisturizing eye pads prepared in Examples 2-5 have good fatigue alleviation efficacy, and it can be known from the comparison between Comparative Examples 1-5 and Examples 2-5 that the addition of sodium chloride, the moisturizing and heat insulation layer, potassium chloride, lactoferrin, adenosine triphosphate-magnesium ion chelate and nano β-nicotinamide mononucleotide can help to improve the anti-fatigue efficacy of the eye pads.

[0063] The above description is merely preferred embodiments of the present application. The protection scope of the present application is not limited to this, and any person skilled in the art can make equivalent replacements or changes according to the technical solutions and the inventive concept of the present application within the technical scope disclosed by the present application, which should be covered by the protection scope of the present application.

[0064] The preferred embodiments of the present application disclosed above are only used to help explain the present application. The preferred embodiments do not describe all the details and do not limit the present application to the specific embodiments. Obviously, many modifications and changes can be made according to the content of the present application. The present application selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present application, so that those skilled in the art can well understand and use the present application. The present application is limited only by the claims and their full scope and equivalents.

Claims

1. A moisturizing eye mask for relieving eye fatigue, characterized in that, The device includes an eye mask body and elastic ear loops connected to the eye mask body. The eye mask body is provided with a moisturizing and heat-insulating layer, a bionic tear layer, a self-heating layer, and an outer cover layer from the inside out. The moisturizing and heat-insulating layer is prepared by soaking cotton non-woven fabric in a moisturizing gel liquid and then combining it with a breathable membrane. The self-heating layer is prepared by laying a heating mixture on a breathable non-woven fabric and sealing it with a gas-barrier film by hot pressing. The bionic tear layer is prepared by bionic tears and non-woven fabric. The two sides of the bionic tear layer are tightly attached to the self-heating layer and the moisturizing and heat-insulating layer, respectively. The eye mask body and the elastic ear loops are welded by hot pressing. The bionic tears are made of rice bran wax ester and phytosterol as lipid phases. The lipid phase is stirred and mixed with an active concentrate to obtain a liposome proemulsion, which is then processed by a membrane extruder.

2. The moisturizing eye mask for relieving eye fatigue according to claim 1, characterized in that, The method for preparing a moisture-retaining and heat-insulating layer includes the following steps: S1. Dissolve glycerin, trehalose, tremella polysaccharide, dipotassium glycyrrhizate, niacinamide and sialic acid in water and stir until completely dissolved to obtain an essence; add sodium hyaluronate to the essence and stir to swell, then add collagen, centella asiatica extract, pro-xylene and lutein to the gel base and stir to obtain a moisturizing gel. S2. Soak the cotton nonwoven fabric in the moisturizing gel liquid, remove it, remove the excess liquid, and then combine it with the breathable membrane to obtain a moisturizing and heat-insulating layer.

3. The moisturizing eye mask for relieving eye fatigue according to claim 2, characterized in that, The mass ratio of glycerol, trehalose, tremella polysaccharide, dipotassium glycyrrhizate, nicotinamide, sialic acid, sodium hyaluronate, collagen, asiaticoside, and water in S1 is (7-10):(3-5):4:(0.5-0.8):(2-4):(0.8-1):(1-1.2):(2-4):(0.5-0.7):(2-3):(0.05-0.07):

100.

4. The moisturizing eye mask for relieving eye fatigue according to claim 1, characterized in that, The method for preparing a self-heating layer includes the following steps: H1. Iron powder, activated carbon, vermiculite, water and sodium chloride are stirred in a sealed mixing pot to obtain a heating mixture; H2. Spread the heating mixture on a breathable non-woven fabric and seal it with a gas-barrier film by heat pressing to obtain a heating pack. Punch a hole on one side of the gas-barrier film to obtain a self-heating layer.

5. The moisturizing eye mask for relieving eye fatigue according to claim 4, characterized in that, The mass ratio of iron powder, activated carbon, vermiculite, water and sodium chloride in H1 is 100:(10-15):(10-20):(30-40):(5-8).

6. The moisturizing eye mask for relieving eye fatigue according to claim 1, characterized in that, The preparation method of the biomimetic tear film includes the following steps: M1. Rice bran wax ester and phytosterol are heated, stirred and mixed, and homogenized under high pressure to obtain the lipid phase; M2. Sodium chloride, potassium chloride, lactoferrin, adenosine triphosphate-magnesium ion chelate, and nano-sized β-nicotinamide mononucleotide were added to phosphate buffer, stirred and dissolved, and then rotary evaporated to obtain an active concentrate. The lipid phase and the active concentrate were stirred and mixed to obtain liposome proemulsion. The liposome proemulsion was passed through a membrane extruder and filtered three times through a membrane with a pore size of 100 nm to obtain biomimetic tears. M3. Soak the nonwoven fabric, dry it, immerse it in liposome colostrum, remove it, squeeze out the excess liposome colostrum, and obtain a nonwoven fabric loaded with biomimetic tears; place the nonwoven fabric loaded with biomimetic tears at the negative ion generator to obtain a biomimetic tear layer.

7. The moisturizing eye mask for relieving eye fatigue according to claim 6, characterized in that, The phytosterols in M1 are obtained by mixing β-sitosterol, stigmasterol and campesterol in a mass ratio of 1:(1-2):

1.

8. The moisturizing eye mask for relieving eye fatigue according to claim 6, characterized in that, The mass ratio of sodium chloride, potassium chloride, lactoferrin, adenosine triphosphate-magnesium ion chelate, nano-sized β-nicotinamide mononucleotide, and phosphate buffer in M2 is (8-8.3):(1-1.2):5:(0.5-0.6):(0.05-0.06):1000.

9. The moisturizing eye mask for relieving eye fatigue according to claim 6, characterized in that, Immersion time in M3 is 30-60 minutes.

10. A method for preparing a moisturizing eye mask to relieve eye fatigue, characterized in that, Includes the following steps: (1) The moisturizing and heat-insulating layer, the biomimetic tear film layer, the self-heating layer and the outer cover layer are stacked from the inside to the outside to make the four-layer structure fit together tightly to obtain the eye mask body; (2) The eye mask body is then connected to the elastic ear hooks by ultrasonic welding to obtain a moisturizing eye mask that relieves eye fatigue.

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