Formula and production process of sweet ginseng shower gel

Abstract

The invention discloses a formula and a production process of a sweet ginseng shower gel, and relates to the technical field of daily chemical products, and the formula comprises the following components by weight: 50-80% of water; 0.5-5% of a sophora flavescens extract; 0.3-3% of a licorice extract; 3-8% of butanediol; 2-6% of glycerin; 5 to 12% of cocamidopropyl betaine; 0.5-2% of sodium chloride; 0.1-1% of a folium artemisiae argyi extract; 0.1-1% of mulberry root and bark extract; 0.1 to 0.8 percent of tea seed extract; 1 to 3% of sodium lauroyl sarcosinate; and the balance of auxiliary components. The matrine and the glycyrrhizic acid are adopted for natural antibacterial combination, synergistic bacteriostasis and synergism are achieved through multiple synergistic effects, the matrine and the glycyrrhizic acid cooperate to achieve a toxicity neutralization effect, drug resistance of a chemical synthesis agent is avoided, low activity of a single extract is avoided, the lasting time of the drug effect is prolonged, and damage to the activity by a high-temperature process is avoided through a low-temperature extract adding process; meanwhile, the problems of precipitation and layering of the traditional decoction are solved through synergistic thickening.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily chemical products, in particular to a formula and production process of a licorice bath foam. BACKGROUND

[0002] Most of the bath foams on the market are not pure natural, and many chemical synthetic substances are added in the formula. In addition to the common surfactants, chemical synthetic antibacterial agents such as triclosan and salicylic acid are commonly used. Although they have certain bacteriostatic effect, long-term use can easily lead to microbial drug resistance, some components can also cause skin irritation, and may damage the skin barrier function, making the skin sensitive and fragile after use, and having a bad influence.

[0003] At the same time, as a traditional Chinese medicine therapy in China, medicated bath has a long history in China. The medicated bath with traditional Chinese medicine not only has the function of bathing, but also can play the role of dispelling disease, protecting skin and beautifying skin through the components of traditional Chinese medicine, and can also make people relaxed and happy. However, the traditional Chinese medicine compound decoction in the traditional medicated bath cannot be directly applied to the washing and protecting products, and there are problems such as low viscosity leading to easy sedimentation of effective components, poor stability, pH sensitive components easy to degrade, and residual drug residue affecting the use experience after bathing.

[0004] There are also some traditional Chinese medicine extract type bath foams, but the utilization rate of single traditional Chinese medicine extract is low, and the bacteriostatic rate is insufficient. Some, such as CN110433107A, a Chinese herbal bath foam, contains sophora flavescens extract, cortex meliae extract, vitex trifolia var. simplicifolia extract, cnidium fruit extract, licorice extract, cortex phellodendri extract and borneol. The Chinese herbal formula is mainly used for the prevention and treatment of skin diseases and moisturizing and whitening of users, but still has some defects leading to limited effect, such as unstable active ingredients, sophoridine is easy to degrade when the pH is greater than 7; the ratio of sophora flavescens and licorice is not controlled, and the simple 1:1 compatibility is unreasonable, the detoxification and synergistic effect is not maximized; the high temperature addition of more than 70 DEG C in the processing technology leads to the inactivation of anti-inflammatory ingredients. The traditional Chinese medicine sophora flavescens and licorice decoction has anti-inflammatory effect, but direct application to washing and protecting products has problems such as poor stability, low compatibility with washing and protecting matrix, low utilization rate of active ingredients, and decreased bacteriostatic activity after room temperature preservation.

[0005] Therefore, in view of the above problems, the present application is produced after in-depth research. SUMMARY

[0006] The purpose of the present application is to provide a formula and production process of a licorice bath foam, so as to solve the problems of drug resistance of chemical synthetic agents in the bath foam and low active retention rate and poor compatibility stability of traditional Chinese medicine extract in the bath foam in the background art.

[0007] To achieve the above object, the present application provides the following technical scheme: a Ganshen shower gel formula, including the following components in percentage by weight: Water 50-80%; Sophora flavescens extract 0.5-5%; Glycyrrhiza uralensis extract 0.3-3%; Butanediol 3-8%; Glycerin 2-6%; Cocamidopropyl betaine 5-12%; Sodium chloride 0.5-2%; Artemisia argyi extract 0.1-1%; Morus alba extract 0.1-1%; Camellia sinensis extract 0.1-0.8%; Sodium lauroyl glutamate 1-3%; The rest is auxiliary ingredients.

[0008] Preferably, the mass ratio of Sophora flavescens extract to Glycyrrhiza uralensis extract is (1.5-2.5):1, optimizing the synergistic effect.

[0009] Preferably, the auxiliary ingredients include a plurality of combinations selected from the following components: Rosa rugosa flower extract 0.05-0.5%; Salvia miltiorrhiza extract 0.1-0.8%; Carbomer 0.1-0.5%; Preservative 0.1-0.3%; Guar gum hydroxypropyltrimonium chloride 0.05-0.2%; Citric acid 0.01-0.1%.

[0010] Preferably, the Sophora flavescens extract contains ≥30% sophoramine, and the Glycyrrhiza uralensis extract contains ≥20% glycyrrhizic acid.

[0011] The production process of the Ganshen shower gel includes the following steps: Step A. Heat the water to 40-50℃, add carbomer and stir until completely dissolved; Step B. Add glycerin, butanediol, cocamidopropyl betaine, and sodium lauroyl glutamate, and stir evenly; Step C. Add Sophora flavescens extract, licorice extract and other plant extracts in sequence, and stir for 30-60 minutes; Step D. Add sodium chloride to adjust viscosity, and add preservatives and citric acid to adjust pH to 5.5-6.5; Step E. Homogenization treatment, and fill after degassing.

[0012] In the thickening synergistic process of sodium chloride and betaine surfactant, the viscosity needs to be added gradually and detected in real time to avoid excessive precipitation or viscosity reduction. A small amount of water is pre-dissolved and added slowly to avoid local high concentration.

[0013] Preferably, the stirring temperature in step C is 45-55°C, and the stirring speed is 200-400 rpm, and the low-temperature extract adds protection to the active ingredients.

[0014] Preferably, the homogenization pressure in step E is 15-25 MPa, and the homogenization times is 2-3 times.

[0015] The components of the Sophora flavescens shower gel are also used in the preparation of products for improving skin folliculitis and acne, products for skin sterilization and insect repellent, and products for promoting skin wound repair.

[0016] Compared with the prior art, the Sophora flavescens shower gel formula and production process have the following beneficial effects: 1. Breakthrough of drug resistance bottleneck of chemical synthesis The natural antibacterial combination of sophoridine and glycyrrhizic acid is adopted to avoid drug resistance of chemical synthesis through multiple synergistic effects: sophoridine specifically destroys parasitic nerve conduction, with EC50 of 0.8 μg / mL for Demodex, and inhibits P. acnes biofilm formation; glycyrrhizic acid inhibits IL-6 and TNF-α inflammatory factors and promotes granulation tissue formation.

[0017] 2. Solve the problem of low activity of single extract The golden ratio of Sophora flavescens: licorice = 1.5-2.5:1 is adopted to achieve synergistic antibacterial effect: compared with single Sophora flavescens extract, the antibacterial effect on Staphylococcus aureus is increased; at the same time, the two have toxicity neutralization effect: the toxicity neutralization effect of licorice neutralizes the bitter cold nature of Sophora flavescens, and the CCK-8 cell toxicity experiment shows that the LD50 is increased from 0.8 mg / mL of single Sophora flavescens to 2.5 mg / mL. Avoiding the low activity of single extract and prolonging the duration of drug effect.

[0018] 3. Avoid and reduce the loss of activity in the process The low-temperature addition extraction process at 45-55℃ avoids the damage of active substances caused by high-temperature process, and the product is detected by HPLC, and the retention rate of matrine is more than 95% compared with 82% of the 70℃ process; the content of oxymatrine is stable at 90.3±2.1% in the 40℃ / 30-day accelerated test.

[0019] 4. Solve the application problem of traditional decoction By the NaCl-betaine synergistic thickening system, the viscosity of the product is stably controlled at 4,500±200 mPa·s at 25℃ by Brookfield RV test, and the problem of traditional decoction precipitation and stratification is solved, and no precipitation is shown in the centrifugal experiment at >4000 rpm. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 The specific data of test results of examples 1-3 and comparative example 1 of the present application are shown in the figure; Figure 2 The parameter comparison data of example 4 and comparative example 2 of the present application are shown in the figure; Figure 3 The specific verification comparison data of example 5 of the present application are shown in the figure. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0022] Please refer to Figures 1-3 The present application provides the following technical solutions: Example 1

[0023] A Ganshen shower gel formula includes the following components by weight percentage: Sophora flavescens extract 2.0%; Glycyrrhiza uralensis extract 1.0%; Butanediol 5.0%; Glycerol 4.0%; Cocamide propyl betaine 8.0%; Sodium chloride 1.2%; Artemisia argyi extract 0.5%; Morus alba root bark extract 0.5%; Camellia sinensis extract 0.4%; Sodium lauroyl amino acid 2.0%; The rest are auxiliary ingredients and water, including Rosa rugosa flower extract 0.25%; Salvia miltiorrhiza extract 0.4%; Carbomer 0.3%; Preservative 0.2%; Guar gum hydroxypropyltrimonium chloride 0.1%; Citric acid 0.05%.

[0024] The mass ratio of Sophora flavescens extract to Glycyrrhiza uralensis extract is 2:1.

[0025] The content of matrine in Sophora flavescens extract is ≥30%, and the content of glycyrrhizic acid in Glycyrrhiza uralensis extract is ≥20%. Example 2

[0026] A Gan Can shower gel formula includes the following components by weight percentage: Sophora flavescens extract 3.5%; Glycyrrhiza uralensis extract 1.5%; Butanediol 6.0%; Glycerin 5.0%; Cocamide propyl betaine 10.0%; Sodium chloride 0.8%; Artemisia argyi extract 0.6%; Morus alba extract 0.6%; Camellia sinensis extract 0.6%; Sodium lauroyl amino acid 3.0%; The rest are auxiliary ingredients and water, including Rosa rugosa flower extract 0.4%; Salvia miltiorrhiza extract 0.6%; Carbomer 0.2%; Preservative 0.2%; Guar gum hydroxypropyltrimonium chloride 0.1%; Citric acid 0.04%.

[0027] The mass ratio of the Sophora flavescens extract to the Glycyrrhiza uralensis extract is 3.5:1.5.

[0028] The Sophora flavescens extract has a matrine content of ≥30%, and the Glycyrrhiza uralensis extract has a glycyrrhizic acid content of ≥20%. Example 3

[0029] A Sophora flavescens shower gel formula includes the following components in percentage by weight: Sophora flavescens extract 1.0%; Glycyrrhiza uralensis extract 0.5%; Butylene glycol 4.0%; Glycerin 3.0%; Cocamidopropyl betaine 6.0%; Sodium chloride 1.5%; Artemisia argyi extract 0.4%; Morus alba extract 0.4%; Camellia sinensis extract 0.4%; Sodium lauroyl glutamate 1%; The rest are auxiliary components and water, including Rosa rugosa flower extract 0.4%; Salvia miltiorrhiza extract 0.4%; Carbomer 0.4%; Preservative 0.2%; Guar hydroxypropyltrimonium chloride 0.1%; Citric acid 0.06%.

[0030] The mass ratio of the Sophora flavescens extract to the Glycyrrhiza uralensis extract is 2:1.

[0031] The Sophora flavescens extract has a matrine content of ≥30%, and the Glycyrrhiza uralensis extract has a glycyrrhizic acid content of ≥20%.

[0032] The antibacterial rate of the product obtained from the above formula example is determined according to QB / T 2738-2012, and the viscosity is determined by Brookfield DV2T. At the same time, Comparative Example 1 is set up to assist in comparing the influence of sodium chloride on viscosity. The test results are shown in Table 1. Figure 1 As shown in Table 1, the viscosity and antibacterial rate of the technical solutions of Examples 1-3 are obviously improved.

[0033] Example 4: Production Process Example Step A. 60% deionized water was heated to 45℃, 0.3% carbomer was added, and stirred until transparent gel; Step B. 5% glycerol, 4% butanediol, 8% cocamidopropyl betaine, sodium lauroyl methylamino acid were added, and stirred for 20 minutes; Step C. Keep 50℃, add 2% sophora flavescens extract, 1% glycyrrhiza extract and other plant extracts in turn, and stir at 400 rpm for 40 minutes; Step D. Add 1.2% sodium chloride, and the viscosity increases from 1,200 mPa·s to 4,500 mPa·s; Step E. Homogenization treatment 20 MPa, 2 times, degassing filling.

[0034] The production process of the Ganjian shower gel includes the following steps: In the thickening synergistic process of sodium chloride and betaine surfactant, the viscosity needs to be added gradually and detected in real time to avoid excessive precipitation or viscosity reduction. By pre-dissolving in 5% water and slowly adding, the local concentration is avoided to be too high.

[0035] Meanwhile, the comparative example 2 uses a high temperature process of 70℃, and the parameter comparison data are as shown in Figure 2 The sophoramine retention rate of the embodiment is improved, and the product stability is effectively enhanced.

[0036] Example 5: efficacy verification experiment Human trial: 30 acne subjects use the product of example 1 component once a day, and after 4 weeks, the inflammatory acne reduction rate is ≥70%, and the skin moisture value is increased by 25%, measured by Corneometer CM825. The specific verification comparison data are as shown in Figure 3 .

[0037] Antibacterial test: the agar diffusion method is used to measure the diameter of the inhibition zone, and the diameters of the inhibition zones of escherichia coli and staphylococcus aureus are detected. The synergistic component of example 1 is compared with sophora extract alone, and it is detected that the diameter of the inhibition zone of staphylococcus aureus is increased by 40%, from 12.3 mm to 17.2 mm.

[0038] The components of the Ganjian shower gel can also be used in products for improving skin folliculitis and acne, products for skin sterilization and insect repellent, and products for promoting skin wound repair.

[0039] The contents not described in detail in the specification belong to the prior art known to those skilled in the art. Although the embodiments of the present application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A formula for a ginseng shower gel, characterized in that, It includes the following components by weight percentage: Water content 50-80%; Sophora flavescens extract 0.5-5%; Licorice extract 0.3-3%; Butanediol 3-8%; Glycerin 2-6%; Cocamidopropyl betaine 5-12%; Sodium chloride 0.5-2%; Artemisia argyi extract 0.1-1%; Mulberry root bark extract 0.1-1%; Tea seed extract 0.1-0.8%; Sodium lauroyl sarcosinate 1-3%; The rest are auxiliary ingredients.

2. The formula for the ginseng shower gel according to claim 1, characterized in that, The mass ratio of the Sophora flavescens extract to the Glycyrrhiza uralensis extract is (1.5-2.5):

1.

3. The formula for the ginseng shower gel according to claim 1, characterized in that, The auxiliary components include a variety of combinations selected from the following components: Rose extract 0.05-0.5%; Salvia miltiorrhiza extract 0.1-0.8%; Carbomer 0.1-0.5%; Preservative 0.1-0.3%; Guar gum hydroxypropyltrimethylammonium chloride 0.05-0.2%; Citric acid 0.01-0.1%.

4. The formula for the ginseng shower gel according to claim 1, characterized in that, The content of matrine in the Sophora flavescens extract is ≥30%, and the content of glycyrrhizic acid in the licorice extract is ≥20%.

5. A production process for the ginseng shower gel as described in any one of claims 1-4, characterized in that, Includes the following steps: Step A. Heat the water to 40-50℃, add carbomer and stir until completely dissolved; Step B. Add glycerin, butylene glycol, cocamidopropyl betaine, and sodium lauroyl sarcosinate, and stir well; Step C. Add Sophora flavescens extract, Glycyrrhiza uralensis extract and other plant extracts in sequence, and stir for 30-60 minutes; Step D. Add sodium chloride to adjust the viscosity, and add preservatives and citric acid to adjust the pH to 5.5-6.5; Step E. Homogenize, degas, and then fill.

6. The production process according to claim 5, characterized in that, The stirring temperature in step C is 45-55℃, and the stirring speed is 200-400 rpm.

7. The production process according to claim 5, characterized in that, In step E, the homogenization pressure is 15-25 MPa, and the homogenization is performed 2-3 times.

8. The use of the ginseng shower gel as described in any one of claims 1-4 in the preparation of products for improving folliculitis and acne.

9. The use of the ginseng shower gel as described in any one of claims 1-4 in the preparation of products for skin sterilization and insect repellency.

10. The use of the ginseng shower gel as described in any one of claims 1-4 in the preparation of a product for promoting the healing of skin wounds.

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