Traditional Chinese medicine for treating gastric ulcer and preparation process

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine for treating gastric ulcer and a preparation process. The traditional Chinese medicine for treating gastric ulcer is prepared from the following raw materials in parts by mass: 2 to 7 parts of radix glehniae, 5 to 10 parts of fructus crataegi, 8 to 13 parts of fructus mume, 1 to 5 parts of flos carthami, 7 to 12 parts of rhizoma curcumae, 2 to 7 parts of radix inulae, 6 to 11 parts of herba taraxaci, 10 to 15 parts of radix salviae miltiorrhizae, 5 to 10 parts of radix glycyrrhizae, 2 to 7 parts of radix paeoniae alba and 5 to 10 parts of radix angelicae sinensis. The traditional Chinese medicine formula carefully selects various natural medicinal materials, has the characteristics of remarkable curative effect, small side effect and the like, and is suitable for clinical treatment and prevention of gastric ulcer.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine for treating gastric ulcer and a preparation process. BACKGROUND

[0002] Gastric ulcer is a common digestive system disease, mainly manifested as a localized ulcer lesion of gastric mucosa under the action of an acid environment and various pathogenic factors. Its pathogenesis is complex, and is usually closely related to factors such as Helicobacter pylori infection, excessive gastric acid secretion, impaired gastric mucosal barrier function, long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), and mental stress.

[0003] In modern medicine, the main treatment methods for gastric ulcer include proton pump inhibitors (PPI), H2 receptor antagonists, gastric mucosa protectants, and antibiotic combination therapy. Although western medicine has a faster effect, long-term use can easily cause side effects such as diarrhea, constipation, vitamin absorption disorders, and even osteoporosis, and there is a high recurrence rate after stopping the drug.

[0004] In recent years, the application of traditional Chinese medicine in the treatment of gastric ulcer has been increasingly valued. Traditional Chinese medicine believes that the causes of gastric ulcer are mainly emotional disorders, improper diet, weak spleen and stomach, or external pathogenic factors. Treatment emphasizes syndrome differentiation and treatment, and focuses on overall conditioning and treatment of both the root and the branch. Traditional Chinese medicine plays a role through multiple mechanisms such as regulating gastrointestinal function, promoting mucosal repair, inhibiting Helicobacter pylori, and enhancing the body's immunity, and has advantages such as stable curative effect, few side effects, and low recurrence rate.

[0005] A Chinese patent with publication number CN115814037B discloses a preparation method of a traditional Chinese medicine composition for treating gastric ulcer. The traditional Chinese medicine composition is composed of costus, gardenia, pomegranate, nandina domestica, cardamom, and piper longum, and has obvious curative effect on treating and preventing gastric ulcer caused by non-steroidal anti-inflammatory drugs.

[0006] The traditional Chinese medicine in the prior art has good therapeutic effect on gastric ulcer. The traditional Chinese medicine in the prior art is mainly aimed at superficial ulcers, and is not ideal for treating deep ulcers. The deep ulcer area is often accompanied by obvious chronic inflammatory reaction, and releases a large amount of inflammatory mediators. These factors not only destroy the surrounding normal tissues, but also inhibit the migration and regeneration of epithelial cells, delaying the healing process. The treatment of deep gastric ulcer is more difficult than that of superficial ulcer, and is more difficult to treat and more likely to relapse. SUMMARY

[0007] The purpose of the present application is to provide a traditional Chinese medicine for treating gastric ulcer and a preparation process.

[0008] In order to achieve the above purpose, the present application provides the following technical scheme: A traditional Chinese medicine for treating gastric ulcer, comprising the following raw materials in parts by mass: 2-7 parts of radix glehniae, 5-10 parts of hawthorn, 8-13 parts of Fructus mume, 1-5 parts of safflower, 7-12 parts of curcuma zedoary, 2-7 parts of radix ligustici wallichii, 6-11 parts of dandelion, 10-15 parts of salvia miltiorrhiza, 5-10 parts of licorice, 2-7 parts of radix paeoniae alba and 5-10 parts of angelica.

[0009] Preferably, safflower, curcuma zedoary and radix ligustici wallichii account for 18-25% of the total mass of raw materials.

[0010] Preferably, the mass ratio of curcuma zedoary and salvia miltiorrhiza is 1:(1-2).

[0011] The blood-activating and stasis-removing effect of safflower can improve local blood circulation, reduce the blood stasis state of ulcer site and promote the generation of new tissues. Curcuma zedoary not only can enhance the blood-activating and stasis-removing effect of safflower, but also can help to eliminate gastric stagnation and relieve pain caused by poor blood circulation through its function of breaking blood and promoting qi flow. Radix ligustici wallichii focuses on invigorating the spleen and stomach and regulating qi and depression, which is helpful to adjust the overall gastrointestinal function and relieve symptoms caused by spleen and stomach disorder. The three components in the composition of the present application have a synergistic effect.

[0012] Preferably, the following raw materials in parts by mass are included: 5 parts of radix glehniae, 7 parts of hawthorn, 11 parts of Fructus mume, 3 parts of safflower, 10 parts of curcuma zedoary, 4 parts of radix ligustici wallichii, 9 parts of dandelion, 12 parts of salvia miltiorrhiza, 6 parts of licorice, 4 parts of radix paeoniae alba and 8 parts of angelica.

[0013] A preparation process of a traditional Chinese medicine for treating gastric ulcer, comprising the following steps: (1) mixing safflower, radix paeoniae alba and radix glehniae and then crushing to obtain a mixed medicinal powder; (2) mixing dandelion, hawthorn, Fructus mume, curcuma zedoary, radix ligustici wallichii, salvia miltiorrhiza, licorice and angelica and then crushing to obtain a mixed material, adding water to the mixed material, soaking, decocting, filtering to obtain an extract, concentrating the extract, freeze-drying to obtain an extract powder; (3) uniformly mixing the mixed medicinal powder and the extract powder to obtain the traditional Chinese medicine for treating gastric ulcer.

[0014] In the raw material composition of the present application, safflower, radix paeoniae alba and radix glehniae are directly ground into powder, and the medicinal materials are treated in two groups respectively, which is helpful to maximize the efficacy.

[0015] Preferably, the decocting conditions are 100-110℃, 2-4 times of decocting, 1-3h each time.

[0016] Preferably, the amount of water added for each decocting is 10-13 times of the mass of the mixed material.

[0017] Preferably, 100 mesh sieve is used for filtering.

[0018] Preferably, the soaking condition is normal temperature for 12-20 hours.

[0019] Preferably, the dandelion, hawthorn, Chinese plum, curcuma zedoary, elecampane, salvia miltiorrhiza, licorice and angelica are mixed and crushed to less than 40 mesh to obtain a mixture.

[0020] Preferably, the safflower, white peony root and north saussurea involucrata are mixed and crushed to less than 100 mesh to obtain a mixed medicine powder.

[0021] North saussurea involucrata, the dry root of the plant of the family of the campanulaceae. Sweet, cold. Nourishing yin and clearing lung, benefiting stomach and generating saliva.

[0022] Hawthorn, sour, sweet, slightly warm. Digestive and stomachic, promoting blood circulation and removing blood stasis.

[0023] Chinese plum, the dried almost mature fruit of the plant of the family of the Rosaceae. Sour and astringent, neutral. Astringe lung to stop cough, astringe intestines to stop diarrhea, expel roundworm to stop pain, generate saliva to stop thirst.

[0024] Safflower, the dried tubular flower of the plant of the family of the compositae. Pungent, warm. Promote blood circulation and remove blood stasis, relieve pain.

[0025] Curcuma zedoary, pungent and bitter, warm. Liver and spleen meridians. Break blood and promote qi, eliminate accumulation and relieve pain. Used for mass, blood stasis, chest and abdominal pain, indigestion, indigestion and other symptoms.

[0026] Elecampane, invigorating spleen and stomach, regulating qi and relieving depression. Used for spleen and stomach disharmony, abdominal distension, loss of appetite, vomiting and diarrhea, emotional disorder and other symptoms.

[0027] Dandelion, clearing heat and resolving toxins, eliminating swelling and resolving masses, diuresis and relieving stranguria. Used for mastitis, red and swollen eyes, yellowish urine, stomach inflammation, stomach ulcer and other symptoms.

[0028] Salvia miltiorrhiza, promoting blood circulation and removing blood stasis, unblocking channels and relieving pain, clearing heart and relieving restlessness, cooling blood and eliminating abscess. Used for irregular menstruation, amenorrhea and dysmenorrhea, mass accumulation, chest and hypochondriac pain, restlessness and insomnia, abscess and swelling and other symptoms.

[0029] Licorice, tonifying spleen and qi, eliminating phlegm and relieving cough, relieving pain, clearing heat and resolving toxins, regulating various drugs. Used for weak spleen and stomach, cough and excessive phlegm, limbs weakness, abdominal pain and diarrhea, drug poisoning and other symptoms.

[0030] White peony root, nourishing blood and regulating menstruation, soothing liver and relieving pain, astringing yin and stopping sweating. Used for irregular menstruation, sweating, abdominal and hypochondriac pain, limbs rigidity, yin deficiency and fever and other symptoms.

[0031] Angelica, tonifying blood and promoting blood circulation, moistening intestines and relieving constipation.

[0032] The traditional Chinese medicine formula is dominated by nourishing Yin and Qi, promoting blood circulation and regulating Qi, invigorating the spleen and stomach, and relieving pain and promoting tissue regeneration. The traditional Chinese medicine components with the effects of anti-inflammatory, anti-oxidation, promoting mucosa repair, regulating immunity, and inhibiting gastric acid secretion are selected, which is especially suitable for the treatment of deep ulcers.

[0033] Compared with the prior art, the advantages and beneficial effects of the present application are: 1. The traditional Chinese medicine formula of the present application selects a variety of natural medicinal materials. The preparation process of the present application includes steps of extraction, concentration, drying, etc. of medicinal materials, which optimizes the retention rate of active ingredients and ensures the stability and bioavailability of the preparation. The traditional Chinese medicine preparation of the present application has the characteristics of significant curative effect and small side effects, and is suitable for the clinical treatment and prevention of gastric ulcer.

[0034] 2. The present application enhances the efficacy by scientific compatibility, specifically including: Beishashen, Shanzha, Wumei, Honghua, E Zhu, Tumuxiang, Dandelion, Danshen, Gancao, Baishao, Danggui, Honghua, E Zhu and Tumuxiang have synergistic effect.

[0035] 3. In the raw materials of the formula of the present application, Honghua, Baishao and Beishashen are directly ground into powder, and the medicinal materials are divided into two groups for separate processing, which helps to maximize the efficacy. The traditional Chinese medicine formula of the present application innovatively divides the medicinal materials into two groups for separate processing in the preparation process. Honghua, Baishao and Beishashen are directly ground into fine powder and kept separately, and the rest of the medicinal materials are extracted by water, concentrated and dried into powder. Finally, the two parts are mixed evenly. This process design fully considers the differences in the physicochemical properties and stability of active ingredients in different medicinal materials, and has significant technical advantages. Honghua, Baishao and Beishashen are ground into powder separately, which can maximize the integrity and biological activity of their effective components. The rest of the medicinal materials are extracted by water, which is beneficial to the dissolution of water-soluble and heat-resistant effective components, improving the extraction efficiency and bioavailability. Scientifically compounding the two parts can ensure the rapid release and absorption of the drug, prolong the overall efficacy time, achieve the purpose of synergistic effect and treating both symptoms and root causes, help to improve the effect of treating deep ulcers and reduce the recurrence rate, and reflect the advanced concept of modern traditional Chinese medicine preparation of "precision processing and fractional extraction".

[0036] 4. The traditional Chinese medicine compound of the present application is designed according to the pathological characteristics of deep ulcers, and can effectively promote the repair and regeneration of deep gastric mucosa tissue through the synergistic effect of multiple components and multiple targets. Deep ulcer patients often have impaired gastric mucosal barrier function, which can easily lead to repeated illness. The traditional Chinese medicine of the present application can enhance the defense mechanism of gastric mucosa, promote the secretion of mucus and bicarbonate, and rebuild the gastric mucosal barrier. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative efforts belong to the protection scope of the present application.

[0038] Embodiment 1 The present embodiment provides a traditional Chinese medicine for treating gastric ulcer, which comprises the following raw materials in parts by mass: 5 parts of north saussurea, 7 parts of hawthorn, 11 parts of Fructus Mume, 3 parts of safflower, 10 parts of curcuma zedoary, 4 parts of inula, 9 parts of dandelion, 12 parts of salvia miltiorrhiza, 6 parts of licorice, 4 parts of white peony root and 8 parts of angelica.

[0039] The preparation process of the traditional Chinese medicine for treating gastric ulcer comprises the following steps: (1) mixing safflower, white peony root and north saussurea, and crushing them to less than 100 meshes to obtain mixed medicine powder; (2) mixing dandelion, hawthorn, Fructus Mume, curcuma zedoary, inula, salvia miltiorrhiza, licorice and angelica, and crushing them to less than 40 meshes to obtain mixed material, adding water to the mixed material, soaking at 25℃ for 18h, and decocting, the decocting conditions being: 100℃, 3 times of decocting, 2h each time, the water amount being 12 times of the mass of the mixed material each time, filtering using a 100-mesh screen to obtain an extract, concentrating the extract, freeze-drying to obtain an extract powder; (3) mixing the mixed medicine powder and the extract powder uniformly to obtain the traditional Chinese medicine for treating gastric ulcer.

[0040] Embodiment 2 The difference between the present embodiment and embodiment 1 is that the traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 5 parts of north saussurea, 8 parts of hawthorn, 10 parts of Fructus Mume, 4 parts of safflower, 10 parts of curcuma zedoary, 5 parts of inula, 8 parts of dandelion, 12 parts of salvia miltiorrhiza, 7 parts of licorice, 5 parts of white peony root and 7 parts of angelica.

[0041] Embodiment 3 The difference between the present embodiment and embodiment 1 is that the traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 7 parts of north saussurea, 8 parts of hawthorn, 10 parts of Fructus Mume, 2 parts of safflower, 9 parts of curcuma zedoary, 4 parts of inula, 6 parts of dandelion, 12 parts of salvia miltiorrhiza, 7 parts of licorice, 7 parts of white peony root and 8 parts of angelica.

[0042] Comparative Example 1 The difference between the present embodiment and embodiment 1 is that the traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 10 parts of north saussurea, 2 parts of hawthorn, 16 parts of Fructus Mume, 8 parts of safflower, 5 parts of curcuma zedoary, 1 part of inula, 3 parts of dandelion, 17 parts of salvia miltiorrhiza, 4 parts of licorice, 10 parts of white peony root and 4 parts of angelica.

[0043] Comparative Example 2 The difference between this example and Example 1 is that a traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 1 part of North Shashan, 15 parts of hawthorn, 5 parts of Fructus Mume, 1 part of safflower, 15 parts of Curcuma, 10 parts of Inula, 13 parts of dandelion, 5 parts of Salvia miltiorrhiza, 15 parts of licorice, 2 parts of white peony root and 12 parts of angelica.

[0044] Comparative Example 3 The difference between this example and Example 1 is that a traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 5 parts of North Shashan, 7 parts of hawthorn, 11 parts of Fructus Mume, 3 parts of safflower, 12 parts of Curcuma, 4 parts of Inula, 9 parts of dandelion, 10 parts of Salvia miltiorrhiza, 6 parts of licorice, 4 parts of white peony root and 8 parts of angelica.

[0045] Comparative Example 4 The difference between this example and Example 1 is that a traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 5 parts of North Shashan, 7 parts of hawthorn, 11 parts of Fructus Mume, 3 parts of safflower, 6 parts of Curcuma, 4 parts of Inula, 9 parts of dandelion, 16 parts of Salvia miltiorrhiza, 6 parts of licorice, 4 parts of white peony root and 8 parts of angelica.

[0046] Comparative Example 5 The difference between this example and Example 1 is that a traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 6 parts of North Shashan, 8 parts of hawthorn, 12 parts of Fructus Mume, 1 part of safflower, 7 parts of Curcuma, 2 parts of Inula, 11 parts of dandelion, 15 parts of Salvia miltiorrhiza, 8 parts of licorice, 6 parts of white peony root and 10 parts of angelica.

[0047] Comparative Example 6 The difference between this example and Example 1 is that a traditional Chinese medicine for treating gastric ulcer comprises the following raw materials in parts by mass: 2 parts of North Shashan, 5 parts of hawthorn, 8 parts of Fructus Mume, 5 parts of safflower, 11 parts of Curcuma, 7 parts of Inula, 6 parts of dandelion, 11 parts of Salvia miltiorrhiza, 5 parts of licorice, 2 parts of white peony root and 5 parts of angelica.

[0048] Comparative Example 7 The difference between this example and Example 1 is that Curcuma is replaced by Piper longum.

[0049] Comparative Example 8 The difference between this example and Example 1 is that Salvia miltiorrhiza is replaced by Pericarpium Citri Reticulatae.

[0050] Comparative Example 9 The difference between the present comparative example and Example 1 is that the preparation process of the traditional Chinese medicine for treating gastric ulcer comprises the following steps: mixing safflower, white peony root, north saussurea, dandelion, hawthorn, bittersweet, zedoary, inula, salvia miltiorrhiza, licorice and angelica, and crushing to less than 40 meshes to obtain a mixture, adding water to the mixture, soaking at 25℃ for 18h, and decocting, the decocting conditions are: 100℃, decocting 3 times, 2h each time, the water addition amount is 12 times the mass of the mixture each time, filtering using a 100 mesh screen to obtain an extract, concentrating the extract, freeze-drying to obtain the traditional Chinese medicine for treating gastric ulcer.

[0051] Comparative Example 10 The present comparative example is the traditional Chinese medicine composition prepared in Example 1 of the preparation method of a kind of traditional Chinese medicine composition for treating gastric ulcer of announcement number CN115814037B.

[0052] Performance test Healthy Kunming mice, body weight 20±2g, were randomly divided into groups, 6 in each group, half male and half female.

[0053] Dosing conditions: Model group: 0.5wt% carboxymethyl cellulose aqueous solution 0.4mL / 20g was orally administered; Omeprazole group: omeprazole 0.4mL / 20g was orally administered; Each test drug group: the traditional Chinese medicine of Example 1-3 and Comparative Examples 1-10 was prepared into medicinal liquid with water in a mass ratio of 1:1, and 0.4mL / 20g of medicinal liquid was orally administered respectively.

[0054] Each group of mice was given medicine once a day for 12 consecutive days. One hour after the last administration, each mouse was given anhydrous ethanol (0.1mL / 20g) by gavage to cause acute gastric mucosal injury. The mice were fasted for 24 hours before modeling and allowed to drink water freely. The mice were sacrificed, the stomach was dissected, washed, and scored according to the degree of lesion. The scoring criteria were as follows: local hyperemia was 1 point; point hemorrhage or erosion was 1 point each, and linear erosion was 2 points for 1 point. Statistical analysis was performed. Calculate the ulcer score and calculate the ulcer inhibition rate, ulcer inhibition rate = (model group ulcer score - administration group ulcer score) / model group ulcer score].

[0055] The results are shown in Table 1.

[0056] Table 1 Test results Ulcer inhibition rate Omeprazole group 60.34 Example 1 57.18 Example 2 54.93 Example 3 52.26 Comparative Example 1 39.57 Comparative Example 2 37.83 Comparative Example 3 46.65 Comparative Example 4 48.38 Comparative Example 5 45.41 Comparative Example 6 42.02 Comparative Example 7 41.65 Comparative Example 8 44.70 Comparative Example 9 40.49 Comparative Example 10 43.11 As can be seen from Table 1, the traditional Chinese medicine of Examples 1-3 can significantly reduce the degree of gastric ulcer lesion in mice caused by anhydrous ethanol.

[0057] In Comparative Examples 1 and 2, the ratio of raw materials was changed, and the ulcer inhibition rate was poor.

[0058] The total proportion of zedoary and salvia miltiorrhiza in the comparative examples 3 and 4 is unchanged, but the proportion is changed, and the treatment effect of the traditional Chinese medicine is also decreased, which shows that the two raw materials are used in combination in the specific proportion in the formula system of the application, and have better ulcer treatment effect.

[0059] The proportion of safflower, zedoary and elecampane in the total raw materials in the comparative examples 5 and 6 is changed, which also affects the treatment effect of the traditional Chinese medicine.

[0060] The treatment effect is decreased after zedoary and salvia miltiorrhiza are replaced in the comparative examples 7-8, which further shows the synergistic effect of the combination of the two in the formula system of the application.

[0061] In the comparative example 9, all raw materials are extracted together, and the treatment effect of the traditional Chinese medicine is decreased, which shows that the raw materials are treated separately in the process of the application, which helps to improve the efficacy.

[0062] Application example Employee Wang, male, 55 years old, diagnosed with acute gastric ulcer, deep ulcer. Dosage: 20g of traditional Chinese medicine of example 1 per day, without taking other drugs during the period, taking for 4 weeks, rechecking, symptoms are relieved, continue to take for another 6 weeks, and the submucosal muscle layer is completely repaired. After that, avoid wine and spicy, follow-up for half a year without recurrence.

[0063] Employee Li, male, 48 years old, diagnosed with acute gastric ulcer, deep ulcer. Dosage: 20g of crude drug of comparative example 4 per day, without taking other drugs during the period, taking for 4 weeks, rechecking, symptoms are relieved, continue to take for another 6 weeks, and the submucosal muscle layer is completely repaired. After that, avoid wine and spicy, follow-up for half a year without recurrence.

[0064] The traditional Chinese medicine of the application has fast treatment effect on deep ulcer and is not easy to recur, and the treatment effect of the traditional Chinese medicine of the application on deep ulcer is better than that of the prior art.

[0065] The above is the preferred embodiment of the application, it should be pointed out that for ordinary skilled in the art, without departing from the principles of the application, can make a number of improvements and refinements, these improvements and refinements should be considered as the protection scope of the application.

Claims

1. A traditional Chinese medicine for treating gastric ulcer, characterized in that, it comprises the following components: The raw materials include the following mass fractions: 2-7 parts of Radix Adenophorae, 5-10 parts of Crataegus pinnatifida, 8-13 parts of Fructus Mume, 1-5 parts of Carthamus tinctorius, 7-12 parts of Curcuma zedoaria, 2-7 parts of Radix Ligustici, 6-11 parts of Taraxacum mongolicum, 10-15 parts of Salvia miltiorrhiza, 5-10 parts of Glycyrrhiza uralensis, 2-7 parts of Radix Paeoniae Alba, and 5-10 parts of Angelica sinensis. ​ 2. The traditional Chinese medicine for treating gastric ulcer according to claim 1, characterized in that, The mass ratio of Curcuma zedoaria and Salvia miltiorrhiza is 1: (1-2).

3. The traditional Chinese medicine for treating gastric ulcer according to claim 2, characterized in that, Carthamus tinctorius, Curcuma zedoaria and Radix Ligustici account for 18-25% of the total mass of the raw materials.

4. The traditional Chinese medicine for treating gastric ulcer according to claim 3, characterized in that, The raw materials include the following mass fractions: 5 parts of Radix Adenophorae, 7 parts of Crataegus pinnatifida, 11 parts of Fructus Mume, 3 parts of Carthamus tinctorius, 10 parts of Curcuma zedoaria, 4 parts of Radix Ligustici, 9 parts of Taraxacum mongolicum, 12 parts of Salvia miltiorrhiza, 6 parts of Glycyrrhiza uralensis, 4 parts of Radix Paeoniae Alba, and 8 parts of Angelica sinensis.

5. A preparation process of the traditional Chinese medicine for treating gastric ulcer according to any one of claims 1-4, characterized in that, The method comprises the following steps: (1) mixing Carthamus tinctorius, Radix Paeoniae Alba and Radix Adenophorae, and crushing to obtain mixed medicinal powder; (2) mixing Taraxacum mongolicum, Crataegus pinnatifida, Fructus Mume, Curcuma zedoaria, Radix Ligustici, Salvia miltiorrhiza, Glycyrrhiza uralensis and Angelica sinensis, crushing to obtain mixed materials, adding water to the mixed materials, soaking, decocting, filtering to obtain an extract, concentrating the extract, and freeze-drying to obtain an extract powder; (3) mixing the mixed medicinal powder and the extract powder uniformly to obtain a traditional Chinese medicine for treating gastric ulcer.

6. The preparation process of the traditional Chinese medicine for treating gastric ulcer according to claim 5, characterized in that, The decocting condition is 100-110°C, and the decocting is performed 2-4 times, each time for 1-3 hours.

7. The preparation process of the traditional Chinese medicine for treating gastric ulcer according to claim 6, characterized in that, The water added in each decocting in step (2) is 10-13 times the mass of the mixed materials.

8. The preparation process of the traditional Chinese medicine for treating gastric ulcer according to claim 5, characterized in that, In step (2), a 100-mesh sieve is used for filtering.

9. The preparation process of the traditional Chinese medicine for treating gastric ulcer according to claim 5, characterized in that, In step (2), the soaking condition is normal temperature for 12-20 hours.

10. The preparation process of the traditional Chinese medicine for treating gastric ulcer according to claim 5, characterized in that, In step (1), Carthamus tinctorius, Radix Paeoniae Alba and Radix Adenophorae are mixed and crushed to less than 100 mesh to obtain the mixed medicinal powder.