Pterostilbene-based stability enhanced antioxidant as well as preparation method and application thereof

By using β-cyclodextrin inclusion and multi-component synergistic protection, combined with disodium ethylenediaminetetraacetate to chelate metal ions, and chitosan quaternary ammonium salt to form a microcarrier with nano-silica, the stability and solubility problems of pterostilbene have been solved, achieving long-term stability and uniform dispersion of pterostilbene, which is suitable for food, cosmetics and pharmaceuticals, reducing production costs and energy consumption.

CN120983282AInactive Publication Date: 2025-11-21WANG SHUHE BIOMEDICINE (WUHAN) CO LTD
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Patent Information

Application Number
CN202511517555.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-23
Publication Date
2025-11-21
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The stability and solubility issues of pterostilbene limit its application in food, cosmetics and pharmaceuticals. Existing technologies cannot achieve long-term stability and uniform dispersion, and the production cost is high, making it difficult to meet industrial needs.

Method used

A dual-stabilization system was constructed by β-cyclodextrin inclusion and multi-component synergistic protection. The system combines disodium ethylenediaminetetraacetate to chelate metal ions, chitosan quaternary ammonium salt and nano-silica to form microcarriers, and polyglycerol fatty acid esters to reduce interfacial tension, thus achieving uniform dispersion of pterostilbene. High-purity pterostilbene was prepared by supercritical CO2 extraction-molecular distillation process, and spray drying was used to optimize the production process.

Benefits of technology

It achieves long-term stability of pterostilbene under normal temperature and humidity conditions, significantly improves the retention rate of pterostilbene, and ensures uniform dispersion of antioxidants in multiphase systems, thereby significantly enhancing antioxidant performance. It is suitable for food, cosmetics and pharmaceuticals, and reduces production costs and energy consumption.

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Abstract

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.
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