Natural herbal compound for adjuvant therapy of AIDS and application thereof

Abstract

The invention discloses a natural herbal compound for adjuvant therapy of AIDS (acquired immune deficiency syndrome) and application thereof, and belongs to the field of medicines. Comprising a green tea extract, a poria cocos extract, a polygonum multiflorum extract, an orange peel extract, a gynostemma pentaphylla extract, a silybum marianum extract, a radix paeoniae alba extract, a spina date seed extract, a honeysuckle extract, a scutellaria baicalensis extract, a lucid ganoderma extract and a liquorice extract. The traditional Chinese medicine preparation taking catechin as a main formula assists in treating AIDS, has small toxic and side effects, is low in cost, reduces toxins of western medicines, and enhances the treatment effect.

Description

Technical Field

[0001] This invention belongs to the field of medicine and relates to a natural herbal compound for adjuvant treatment of AIDS and its application. Background Technology

[0002] AIDS is a serious infectious disease caused by the human immunodeficiency virus (HIV), and there is currently no cure. Existing treatment strategies mainly rely on highly active antiretroviral therapy (HAART), which can effectively suppress viral replication, but long-term use may lead to problems such as drug resistance, drug side effects, and decreased quality of life. Summary of the Invention

[0003] The purpose of this invention is to provide a natural herbal compound for adjuvant treatment of AIDS and its application, thereby solving the above-mentioned problems.

[0004] The technical solution adopted in this invention is as follows: A natural herbal complex for adjunctive treatment of AIDS, comprising green tea extract, Poria cocos extract, Polygonum multiflorum extract, tangerine peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract.

[0005] The main component of green tea extract is catechin, which has been proven to have significant antiviral effects. It can directly inhibit the binding of HIV's gp120 to the CD4 molecule on the surface of host cells, thereby inhibiting the fusion of HIV-infected and uninfected cells. Furthermore, catechin can also inhibit the activity of HIV reverse transcriptase and protease, thus inhibiting HIV proliferation in the body and exerting its antiviral effect. Catechins can bind to the HIV receptor CD4, thereby reducing the expression of CD4 on the cell surface and competitively inhibiting the binding of HIV to CD4, thus protecting some immune lymphocytes from attack; this is crucial for maintaining the immune function of AIDS patients. This invention relates to a multi-component traditional Chinese medicine preparation with catechins as the main ingredient, which is used as an adjunct treatment for AIDS. It has fewer toxic side effects, is inexpensive, reduces the toxicity of Western medicines and enhances the therapeutic effect, while protecting the liver and kidneys and effectively treating adverse reactions such as dizziness, diarrhea, rash, herpes, general weakness, fever and other symptoms, and preventing cardiovascular diseases.

[0006] in: Poria cocos extract: It has the effects of diuresis, strengthening the spleen and calming the mind, and can improve the common symptoms of edema and spleen and stomach weakness in AIDS patients.

[0007] Polygonum multiflorum extract: nourishes the liver and kidneys, replenishes essence and blood, and helps enhance the body's immunity and improve the systemic symptoms of HIV patients.

[0008] Orange peel extract: It can regulate qi and promote digestion, dry dampness and resolve phlegm, and relieve indigestion and respiratory symptoms caused by drugs in HIV patients.

[0009] Gynostemma pentaphyllum extract: It invigorates qi and strengthens the spleen, clears heat and detoxifies, enhances immunity, and reduces drug side effects while fighting HIV infection.

[0010] Milk thistle extract: protects the liver and detoxifies, protecting the liver from damage caused by antiviral drugs.

[0011] White peony extract: nourishes blood and regulates menstruation, soothes the liver and relieves pain, improves the endocrine system and relieves pain in HIV patients.

[0012] Ziziphus jujuba seed extract: Nourishes the heart and calms the mind, and helps improve sleep disorders and anxiety in HIV patients.

[0013] Honeysuckle extract: Clears heat and detoxifies, fights HIV infection, and relieves symptoms such as fever.

[0014] Scutellaria baicalensis extract: clears heat and dries dampness, cools blood and detoxifies, and helps control inflammation and infection caused by HIV infection.

[0015] Ganoderma lucidum extract: It replenishes qi and calms the mind, enhances immunity, and is a traditional immunomodulator that helps improve the overall health of HIV patients.

[0016] Licorice extract: harmonizes various medicines, enhances the efficacy of other herbal ingredients, and reduces drug side effects.

[0017] Furthermore, the aforementioned natural herbal complex for adjuvant treatment of AIDS is characterized by comprising the following components in weight fractions: 70-80 parts green tea extract, 5-30 parts Poria cocos extract, 5-10 parts Polygonum multiflorum extract, 10-15 parts tangerine peel extract, 5-15 parts Gynostemma pentaphyllum extract, 5-15 parts milk thistle extract, 5-30 parts Paeonia lactiflora extract, 10-45 parts Ziziphus jujuba seed extract, 10-45 parts honeysuckle extract, 5-30 parts Scutellaria baicalensis extract, 3-8 parts Ganoderma lucidum extract, and 5-10 parts licorice extract.

[0018] Furthermore, the aforementioned natural herbal complex for adjuvant treatment of AIDS comprises the following components in weight fractions: 78 parts green tea extract, 25 parts Poria cocos extract, 6 parts Polygonum multiflorum extract, 15 parts tangerine peel extract, 10 parts Gynostemma pentaphyllum extract, 10 parts milk thistle extract, 15 parts white peony root extract, 35 parts jujube seed extract, 35 parts honeysuckle extract, 15 parts Scutellaria baicalensis extract, 5 parts Ganoderma lucidum extract, and 10 parts licorice extract.

[0019] Furthermore, the green tea extract contains more than 90% catechins.

[0020] Application of a natural herbal compound for adjunctive treatment of AIDS, used in the preparation of drugs for adjunctive treatment of AIDS.

[0021] Furthermore, the adjunctive treatment drug for AIDS is prepared by the following method: S1. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract were prepared by supercritical fluid extraction. S2. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract are mixed in a certain proportion to obtain a mixed plant extract for later use. S3. Heat the tender honey, keeping the temperature between 110℃ and 116℃, to obtain refined honey; S4. After cooling the refined honey to 20-25℃, mix it evenly with the mixed plant extracts in a certain proportion to obtain the medicinal clump; S5. Prepare the drug mass into honey pills, dry and sterilize the honey pills, and then package them to obtain the finished product, which is a pill for adjuvant treatment of AIDS.

[0022] Furthermore, in step S4, the ratio of mixed plant extracts to refined honey is generally 1:1-1.5.

[0023] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: 1. A natural herbal compound for adjuvant treatment of AIDS, a traditional Chinese medicine preparation with catechin as the main ingredient, has few toxic side effects, low cost, reduces the toxicity of Western medicine and enhances the therapeutic effect. 2. This invention utilizes the synergistic effect of multiple components, which simultaneously protects the liver and kidneys, effectively treats adverse reactions such as dizziness, diarrhea, rash, herpes, general weakness, fever, and prevents cardiovascular diseases. 3. This invention can be used in conjunction with HAART therapy to improve treatment efficacy. Attached Figure Description

[0024] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort, wherein: Figure 1 This is a flowchart of the preparation process of the present invention; Figure 2 It is a natural herbal compound used as an adjunct treatment for AIDS and its applications. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention; that is, the described embodiments are merely some embodiments of the invention, and not all embodiments. The components of the embodiments of the invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0026] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0027] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0028] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0029] This invention provides a natural herbal complex for adjuvant treatment of AIDS, comprising green tea extract, Poria cocos extract, Polygonum multiflorum extract, tangerine peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract.

[0030] The aforementioned natural herbal complex for adjuvant treatment of AIDS comprises the following components in weight fractions: 70-80 parts green tea extract, 5-30 parts Poria cocos extract, 5-10 parts Polygonum multiflorum extract, 10-15 parts tangerine peel extract, 5-15 parts Gynostemma pentaphyllum extract, 5-15 parts milk thistle extract, 5-30 parts white peony root extract, 10-45 parts jujube seed extract, 10-45 parts honeysuckle extract, 5-30 parts Scutellaria baicalensis extract, 3-8 parts Ganoderma lucidum extract, and 5-10 parts licorice extract.

[0031] In some embodiments, the natural herbal complex for adjunctive treatment of AIDS comprises the following components in weight fractions: 78 parts green tea extract, 25 parts Poria cocos extract, 6 parts Polygonum multiflorum extract, 15 parts tangerine peel extract, 10 parts Gynostemma pentaphyllum extract, 10 parts milk thistle extract, 15 parts white peony root extract, 35 parts jujube seed extract, 35 parts honeysuckle extract, 15 parts Scutellaria baicalensis extract, 5 parts Ganoderma lucidum extract, and 10 parts licorice extract.

[0032] The green tea extract contains more than 90% catechins.

[0033] The application of the aforementioned natural herbal compound for adjuvant treatment of AIDS is used to prepare drugs for adjuvant treatment of AIDS.

[0034] like Figure 1 As shown, the adjunctive treatment drug for AIDS is prepared by the following method: S1. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract were prepared by supercritical fluid extraction. S2. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract are mixed in a certain proportion to obtain a mixed plant extract for later use. S3. Heat the tender honey, keeping the temperature between 110℃ and 116℃, to obtain refined honey; S4. After cooling the refined honey to 20-25℃, mix it evenly with the mixed plant extracts in a certain proportion to obtain the medicinal clump; S5. Prepare the drug mass into honey pills, dry and sterilize the honey pills, and then package them to obtain the finished product, which is a pill for adjuvant treatment of AIDS.

[0035] In step S4, the ratio of mixed plant extracts to refined honey is generally 1:1-1.5.

[0036] Example 1 The preferred embodiment of this invention provides the application of a natural herbal compound for adjuvant treatment of AIDS, wherein pills for adjuvant treatment of AIDS are prepared by the following method: S1. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract were prepared by supercritical fluid extraction. S2. Mix 78 parts green tea extract, 25 parts Poria cocos extract, 6 parts Polygonum multiflorum extract, 15 parts tangerine peel extract, 10 parts Gynostemma pentaphyllum extract, 10 parts milk thistle extract, 15 parts white peony root extract, 35 parts jujube seed extract, 35 parts honeysuckle extract, 15 parts Scutellaria baicalensis extract, 5 parts Ganoderma lucidum extract, and 10 parts licorice extract to obtain a mixed plant extract for later use. S3. Heat the tender honey at 116℃ to obtain refined honey; S4. After cooling the refined honey to 25°C, mix it evenly with the mixed plant extract in a certain ratio to obtain the medicinal lumps; the ratio of the mixed plant extract to the refined honey is generally 1:1.5. S5. Prepare the drug mass into honey pills, dry and sterilize the honey pills, and then package them to obtain the finished product, which is a pill for adjuvant treatment of AIDS.

[0037] The quality and technical requirements comply with the Chinese Pharmacopoeia and the guidance documents issued by the National Medical Products Administration regarding the production, storage, and transportation of pills.

[0038] Some real-world examples: Case 1 In 2016, commissioned by relevant agencies of the Dujiangyan Municipal Government, we jointly treated multiple HIV / AIDS patients in the region. The treatment period was from May 2016 to August 2017, with patients aged 21-62 who signed informed consent forms. Simultaneously, they underwent liver and kidney examinations at the same hospital in Pengzhou, and immunological and viral load tests at the Chengdu Public Health Clinical Medical Center. During treatment, patients experienced significant relief from symptoms such as fatigue, fever, vomiting, diarrhea, and rashes. Test data showed a decrease in viral load, and liver and kidney function returned to normal.

[0039] Case 2 Research Subject Information: Wang, 46 years old. This patient had been infected with HIV for many years and signed an informed consent form. Initially, he suffered from skin ulcers on his arms, which progressed to his entire body after two years of various treatments. He was later diagnosed with HIV, and his immune system was on the verge of collapse. He agreed to receive the medication applied for in this application. After about ten days, the skin ulcers began to scab over and new tissue grew. The treatment process was painless and non-irritating. After about a month, the skin ulcers healed without scarring. A follow-up visit six months later showed no recurrence. During the treatment, monitoring showed an increase in immune cells (CD4 increased from 1137 / μL to 190 / μL, and CD8 increased to 933 / μL during the active viral phase, entering the antiviral phase). The viral load was controlled (from 2.46E+5 to 4.50E+4 copies / mL), and there was no damage to liver and kidney function. Skin treatment images are shown below. Figure 2 As shown.

[0040] Case 3 Research subject information: Li, 25 years old, had been undergoing HIV antiviral treatment for more than two years, with varying degrees of liver and kidney damage. He signed an informed consent form. After receiving the drug applied for, he stopped Western antiviral treatment. He had a low-grade fever and cough, which disappeared in about a week. After a period of treatment, his immune cells increased (CD4 increased from 206 / μL to 334 / μL, and CD8 increased to 1225 / μL when the virus was active, entering the antiviral phase), and his viral load decreased (from 7.70E+4 to 5.00E+2 copies / mL). His liver and kidney functions were repaired.

[0041] Case 4 Mr. Wang: 61 years old, had been undergoing antiviral treatment for many years, resulting in liver and kidney damage. After signing the informed consent form and receiving the medication applied for, he stopped taking Western antiviral medication, and his liver and kidney function was repaired. His immune cells were enhanced (CD4 count increased from 318 / μL to 480 / μL, and the virus remained inactive with CD8 count within the normal range).

[0042] The above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, and improvements made by those skilled in the art within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A natural herbal complex for adjuvant treatment of AIDS, characterized in that: It includes green tea extract, Poria cocos extract, Polygonum multiflorum extract, tangerine peel extract, Gynostemma pentaphyllum extract, milk thistle extract, white peony root extract, jujube seed extract, honeysuckle extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and licorice extract.

2. The natural herbal complex for adjuvant treatment of AIDS according to claim 1, characterized in that: The product contains the following components by weight fraction: 70-80 parts green tea extract, 5-30 parts Poria cocos extract, 5-10 parts Polygonum multiflorum extract, 10-15 parts tangerine peel extract, 5-15 parts Gynostemma pentaphyllum extract, 5-15 parts milk thistle extract, 5-30 parts white peony root extract, 10-45 parts jujube seed extract, 10-45 parts honeysuckle extract, 5-30 parts Scutellaria baicalensis extract, 3-8 parts Ganoderma lucidum extract, and 5-10 parts licorice extract.

3. The natural herbal complex for adjuvant treatment of AIDS according to claim 2, characterized in that: The components include the following components by weight: 78 parts green tea extract, 25 parts Poria cocos extract, 6 parts Polygonum multiflorum extract, 15 parts tangerine peel extract, 10 parts Gynostemma pentaphyllum extract, 10 parts milk thistle extract, 15 parts white peony root extract, 35 parts jujube seed extract, 35 parts honeysuckle extract, 15 parts Scutellaria baicalensis extract, 5 parts Ganoderma lucidum extract, and 10 parts licorice extract.

4. The natural herbal complex for adjuvant treatment of AIDS according to claim 1, characterized in that: The green tea extract contains more than 90% catechins.

5. The application of a natural herbal compound for adjuvant treatment of AIDS according to any one of claims 1-4, characterized in that: Used to prepare drugs for adjunctive treatment of AIDS.

6. The application of the natural herbal complex for adjuvant treatment of AIDS according to claim 5, characterized in that: The adjunctive therapy drug for AIDS is prepared by the following method: S1. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract were prepared by supercritical fluid extraction. S2. Green tea extract, Poria cocos extract, Polygonum multiflorum extract, Citrus peel extract, Gynostemma pentaphyllum extract, Milk thistle extract, Paeonia lactiflora extract, Ziziphus jujuba seed extract, Lonicera japonica extract, Scutellaria baicalensis extract, Ganoderma lucidum extract, and Glycyrrhiza uralensis extract are mixed in a certain proportion to obtain a mixed plant extract for later use. S3. Heat the tender honey, keeping the temperature between 110℃ and 116℃, to obtain refined honey; S4. After cooling the refined honey to 20-25℃, mix it evenly with the mixed plant extracts in a certain proportion to obtain the medicinal clump; S5. Prepare the drug mass into honey pills, dry and sterilize the honey pills, and then package them to obtain the finished product, which is a pill for adjuvant treatment of AIDS.

7. The application of the natural herbal complex for adjuvant treatment of AIDS according to claim 6, characterized in that: In step S4, the ratio of mixed plant extracts to refined honey is generally 1:1-1.5.

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