Pharmaceutical composition containing oxathiapiprolin, suspending agent, preparation method and application

Abstract

The invention discloses a pharmaceutical composition containing oxathiapiprolin, the pharmaceutical composition comprises fluopicolide and oxathiapiprolin, the weight ratio of fluopicolide to oxathiapiprolin is (1-2): (4-11), and the pharmaceutical composition has a synergistic effect on potato late blight and cucumber downy mildew. The product particle size is small, the product can be better absorbed and permeated by crops, the pesticide effect is improved, the product is a water-based suspending agent, and the product is environmentally friendly in dosage form, environmentally friendly, low in toxicity and small in harm to human and other beneficial organisms.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of chemical medicine preparation, in particular to a pharmaceutical composition containing fluopicolide, a suspension agent, a preparation method and an application field. BACKGROUND

[0002] With the large use of pesticides, many agricultural diseases have developed drug resistance, so it is necessary to develop new pesticide compositions to adapt to new agricultural diseases and pests and slow down the development of drug resistance. Fluopicolide and fluopicolide can be used as plant fungicides in combination, but the particle size of fluopicolide technical material is uneven, and the surface is rough, so that the suspension agent prepared therefrom is prone to stratification or flocculation. Therefore, it is crucial to improve the stability of the suspension agent prepared by combining fluopicolide and fluopicolide and to improve the control effect of plant diseases.

[0003] Chinese patent application CN104336024A discloses a fungicidal composition containing fluopicolide and amide, the weight ratio of fluopicolide to fluopicolide is (1-20):(1-20), which is used for preventing and controlling plant diseases such as blight, mildew, blight, blight and the like, but the control effect of the fungicide is not good, and the synergistic effect cannot be achieved. Chinese patent application CN119874621A discloses a pharmaceutical composition containing pyrazole ether compounds and its application, which uses two fungicides such as pyrazole ether compounds to combine, so that the pharmaceutical composition has higher biological activity, can reduce the application amount of the compounds and compositions required for effectively controlling plant pathogens, and has longer lasting activity, but the plant adhesion of the suspension agent prepared therefrom is poor, and it is easy to be washed away in the rainy season. SUMMARY

[0004] In order to improve the stability of the suspension agent prepared by combining fluopicolide and fluopicolide and to improve the control effect of plant diseases, the first aspect of the present application provides a pharmaceutical composition containing fluopicolide, which comprises fluopicolide and fluopicolide, and the weight ratio of fluopicolide to fluopicolide is (1-2):(4-11).

[0005] The second aspect of the present application provides a fluopicolide·fluopicolide suspension agent, which contains the above-mentioned pharmaceutical composition.

[0006] As an embodiment, the preparation raw material comprises, by weight percentage, 10-40% of the pharmaceutical composition, 1-8% of the wet dispersant, 1-5% of the synergist, 1-3% of the thickening agent, 0.01-0.1% of the anti-decomposition agent, 1-5% of the grinding aid, 3-8% of the antifreeze agent, 0.1-0.3% of the preservative, and deionized water is supplemented to 100%.

[0007] As an implementation form, the wetting dispersant comprises at least two of a hydrophobic group modified carboxylic copolymer, an alkyl aryl polyether polyol phosphate, a polycarboxylic acid, a phosphate ester, a sulfonate, and a sodium alkyl naphthalene sulfonate formaldehyde condensate.

[0008] As an implementation form, the wetting dispersant comprises a combination of the polycarboxylic acid and the sodium alkyl naphthalene sulfonate formaldehyde condensate.

[0009] As an implementation form, the weight ratio of the polycarboxylic acid and the sodium alkyl naphthalene sulfonate formaldehyde condensate is (3-5):1.

[0010] As an implementation form, the weight ratio of the polycarboxylic acid and the sodium alkyl naphthalene sulfonate formaldehyde condensate is 4:1.

[0011] As an implementation form, the polycarboxylic acid is a special structure polymerized carboxylic acid macromolecule, which is purchased from Qianyu, and the model number is SP-SC3275.

[0012] In the present application, the combination of SP-SC3275 and the sodium alkyl naphthalene sulfonate formaldehyde condensate can prepare a product with low viscosity and high suspension rate, and can inhibit the increase of the particle size of the sample after heat storage, thereby ensuring the time stability of the product.

[0013] As an implementation form, the synergist comprises at least one of a polyvinyl acetate, a polyvinyl pyrrolidone, an acrylic resin polymer, and an acrylic polymer.

[0014] As an implementation form, the synergist is an acrylic polymer.

[0015] The surface of a plant leaf generally has a wax layer with strong hydrophobicity. The use of a water agent type suspension agent makes it difficult for the pesticide to wet the plant leaf, and the long-term retention and prevention effect cannot be exerted. By introducing an acrylic polymer as a synergist, the interfacial tension between the plant and the pesticide liquid can be better reduced, the wetting and spreading effect of the pesticide liquid drop can be strengthened, the affinity of the crop surface can be enhanced, and after the pesticide is washed by rain, the pesticide can still be well attached, so as to better exert the effect.

[0016] As an implementation form, the thickening agent comprises at least two of magnesium aluminum silicate, xanthan gum, and attapulgite.

[0017] As an implementation form, the xanthan gum is added twice, and the xanthan gum comprises primary xanthan gum and secondary xanthan gum.

[0018] As an implementation form, the thickening agent is a combination of magnesium aluminum silicate and xanthan gum.

[0019] As an implementation form, the weight ratio of the magnesium aluminum silicate and the xanthan gum is (5-7):1.

[0020] As an implementation form, the weight ratio of the magnesium aluminum silicate and the xanthan gum is 6:1.

[0021] The inventors found in the experiment that the combination of the magnesium aluminum silicate and the xanthan gum can improve the thermal storage water property of the medicament, which may be due to the fact that the combination of the magnesium aluminum silicate and the xanthan gum can control the viscosity of the medicament, maintain the dispersion effect of the medicament particles after thermal storage, reduce the stratified water, and meet the thermal storage requirements of the suspension agent.

[0022] As an implementation form, the grinding aid is an alkoxylated ethylenediamine, and the molecular weight of the alkoxylated ethylenediamine is 800-1200.

[0023] In order to improve the suspension stability of the suspension agent, the present application performs nano sanding, and adds a low-molecular-weight alkoxylated ethylenediamine to form a nano preparation, thereby increasing the sanding efficiency and reducing the sanding time. The inventors further found that after adding the low-molecular-weight alkoxylated ethylenediamine, the amount of foam decreases, thereby avoiding the problem of overflow. It is also found that after adding the alkoxylated ethylenediamine with a molecular weight of 1000, the particle size of the preparation changes little after thermal storage, thereby avoiding the problems of creaming and crystallization.

[0024] As an implementation form, the antifreeze agent includes at least one of ethylene glycol, ethylene glycol, glycerol, or sodium chloride.

[0025] As an implementation form, the antifreeze agent includes at least one of ethylene glycol, ethylene glycol, or glycerol.

[0026] In the present application, one of ethylene glycol, ethylene glycol, or glycerol is used as an antifreeze agent, which can improve the low-temperature resistance effect and avoid the problems of thickening and solidification creaming during sanding.

[0027] The third aspect of the present application provides a preparation method of fluazinam · flutioacetam suspension agent, which comprises the following steps:

[0028] Mixing and shearing the deionized water, wetting dispersant, synergist, grinding aid, and antiseptic to disperse;

[0029] Adding the pharmaceutical composition, uniformly dispersing, then adding the premixed solution of the magnesium aluminum silicate, the first xanthan gum, and the antifreeze agent, and shearing for 20-40 min for nano sanding;

[0030] Sanding to D90 particle size <0.5 μm, wet screening after sanding, adding the preservative, the second xanthan gum, and ethylene glycol, and shearing for 20-40 min to obtain the fluazinam · flutioacetam suspension agent.

[0031] The inventor adds the defoaming agent to reduce bubble generation in the shearing and stirring process, can more quickly defoam the sand-milled material, and does not reduce the defoaming effect.

[0032] As an implementation form, the weight ratio of the primary xanthan gum and the secondary xanthan gum is 1:(1-3).

[0033] The inventor adds the xanthan gum in sections to reduce material settlement due to gravity before sand milling, to cause continuous production, and to avoid xanthan gum thickening performance reduction due to multiple grinding in the sand milling process.

[0034] The third aspect of the application provides a fluazinam·flutiothiol al suspension agent, which is applied to the prevention and treatment of potato late blight and cucumber downy mildew.

[0035] Compared with the prior art, the application has the following beneficial effects:

[0036] (1) The pharmaceutical composition containing flutiothiol al in the application adopts the weight ratio of fluazinam and flutiothiol al of (1-2):(4-11), and the combination of the medicament has a synergistic effect on potato late blight and cucumber downy mildew.

[0037] (2) The fluazinam·flutiothiol al suspension agent in the application adopts the combination of polycarboxylic acid and sodium alkyl naphthalene sulfonate formaldehyde condensate as a wetting dispersant to prepare a product with low viscosity and high suspension rate, and can inhibit the increase in particle size of the sample after heat storage, thereby ensuring the stability of the product over time.

[0038] (3) The fluazinam·flutiothiol al suspension agent in the application adopts an acrylic polymer as a synergist to better reduce the interfacial tension between the plant and the liquid, strengthen the wetting and spreading of the pesticide droplets, enhance the affinity of the crop surface, and enable the medicament to still be well attached after being washed by rainwater, thereby making the efficacy more durable.

[0039] (4) The fluazinam·flutiothiol al suspension agent in the application adds an alkoxylated ethylenediamine with a molecular weight of 1000 to reduce the increase in foam, avoid the problem of overflow, and little change in the particle size of the preparation after heat storage, thereby avoiding the problems of creaming and crystallization.

[0040] (5) The preparation method of the fluazinam·flutiothiol al suspension agent in the application adds xanthan gum in sections to make the particle size of the medicament in the suspension agent uniform, reduce the amount of foam in the shearing and sand milling process, and avoid the problem of overflow.

[0041] (6) The fluazinam·oxpoconazole suspension agent described in the present application is nano-sand-milled to make the product particle size smaller, which can be better absorbed and penetrated by crops, improve the efficacy, is a water-based suspension agent, the dosage form is environmentally friendly, friendly to the environment, low toxicity, and less harmful to humans and other beneficial organisms.

[0042] (7) The fluazinam·oxpoconazole suspension agent described in the present application has a small dosage, higher safety to users, agricultural producers and the environment, is highly effective against the pathogenic oomycete Phytophthora infestans that causes potato and tomato late blight, is effective against each development stage of the pathogenic oomycete, can be long-distance transported in the host plant body, and can effectively prevent and control the late blight even in extremely harsh conditions. The prevention and control object is the Oomycetes pathogenic fungi that affect the yield and economic benefits of grapes, melons, tomatoes and other fruits and vegetables. BRIEF DESCRIPTION OF DRAWINGS

[0043] Figure 1 The actual picture of the suspension agent after heat storage of Example 1;

[0044] Figure 2 The actual picture of the suspension agent after heat storage of Comparative Example 1;

[0045] Figure 3 The actual picture of the suspension agent after heat storage of Comparative Example 2;

[0046] Figure 4 The actual picture of the suspension agent after heat storage of Comparative Example 3;

[0047] Figure 5 The particle size distribution picture of the suspension agent of Example 1 before heat storage;

[0048] Figure 6 The particle size distribution picture of the suspension agent of Example 1 after heat storage;

[0049] Figure 7 The particle size distribution picture of the suspension agent of Comparative Example 4 after heat storage;

[0050] Figure 8 The sieving and crystallization picture of the suspension agent of Comparative Example 4 after heat storage;

[0051] Figure 9 The layering and water analysis picture of the suspension agent of Example 1 after heat storage;

[0052] Figure 10 The layering and water analysis picture of the suspension agent of Comparative Example 5 after heat storage;

[0053] Figure 11 The layering and water analysis picture of the suspension agent of Comparative Example 6 after heat storage;

[0054] Figure 12 The layering and water analysis picture of the suspension agent of Comparative Example 7 after heat storage;

[0055] Figure 13 The photos of the adhesion of the suspension agent of Example 1 after spraying on the leaves;

[0056] Figure 14 The photos of the adhesion of the suspension agent of Comparative Example 8 after spraying on the leaves;

[0057] Figure 15 The photos of the suspension agent of Example 1 during preparation;

[0058] Figure 16 The photos of the suspension agent of Comparative Example 9 during preparation. DETAILED DESCRIPTION

[0059] Example 1

[0060] A fluazinam · flutiothyl alcofen suspension agent, the raw materials for preparation include, by weight percentage, pharmaceutical composition 15%, wetting dispersant 5%, synergist 4%, thickening agent 1.4%, anti-decomposition agent 0.03%, grinding aid 3%, antifreeze 4%, preservative 0.1%, and deionized water is supplemented to 100%.

[0061] The pharmaceutical composition is fluazinam and flutiothyl alcofen, and the weight ratio is 12:3.

[0062] The wetting dispersant is a combination of a special structure of polymeric carboxylic acid macromolecule and sodium alkyl naphthalene sulfonate formaldehyde condensate, and the weight ratio is 4:1; the special structure of polymeric carboxylic acid macromolecule is purchased from Chengyu, and the model number is SP-SC3275; the sodium alkyl naphthalene sulfonate formaldehyde condensate is purchased from Nanjing Jetlun, and the model number is Morwet D-500.

[0063] The synergist is an acrylic polymer, which is purchased from Dow, and the model number is filmer-17.

[0064] The thickening agent is a combination of magnesium aluminum silicate and xanthan gum, and the weight ratio is 1.2:0.2.

[0065] The xanthan gum is added twice, including primary xanthan gum and secondary xanthan gum.

[0066] The anti-decomposition agent is polydimethylsiloxane, which is purchased from Nanjing Jetlun, and the model number is SAG 1572.

[0067] The grinding aid is alkoxylated ethylenediamine, and the molecular weight is 1000, which is purchased from Huita, and the model number is SYNPERONIC T-304.

[0068] The antifreeze is ethylene glycol. The preservative is BIT20, which is purchased from Wanhou Biology.

[0069] A preparation method of fluazinam·fluoro-thiacept acetone suspension agent, comprising the following steps:

[0070] Mixing and shearing dispersing deionized water, wet dispersant, synergist, grinding aid and anti-deterioration agent;

[0071] Adding the pharmaceutical composition, uniformly dispersing, then adding the premixed solution of magnesium aluminum silicate, primary xanthan gum and antifreeze, shearing for 30 min, and nano sand grinding;

[0072] Grinding until the D90 particle size is less than 0.5 μm, detecting the wet sieve after sand grinding, adding preservative, secondary xanthan gum and ethylene glycol after passing, shearing for 30 min, to obtain fluazinam·fluoro-thiacept acetone suspension agent.

[0073] The weight ratio of the primary xanthan gum and the secondary xanthan gum is 1:2.

[0074] The physical picture after heat storage is shown in Figure 1 , the particle size distribution picture before heat storage is shown in Figure 5 , the particle size distribution picture after heat storage is shown in Figure 6 , and the particle size normal distribution is normal after heat storage.

[0075] The picture of layered water analysis after heat storage is shown in Figure 9 , and the water analysis amount is 1 / 7, meeting the requirement.

[0076] According to 1wt% concentration, the suspension agent is diluted in pigment aqueous solution (color product can not need to add pigment). Equal amount of 0.1g to 0.5 is dropped on the test leaf (green) surface, and the rainstorm is simulated at 0.5L / min speed after placing at normal temperature for 2h by using a spraying device. The spraying effect is observed after spraying for 20 min, shown in Figure 13 , and the suspension agent spot on the leaf blade is deep and has good adhesion.

[0077] The picture during preparation is shown in Figure 15 , and the foaming is less.

[0078] Comparative example 1

[0079] A fluazinam·fluoro-thiacept acetone suspension agent and a preparation method thereof, the specific implementation is the same as example 1, and the difference lies in that the mass percentage of the wet dispersant is 2%, and the wet dispersant is alkyl aryl polyether polyol phosphate, purchased from Gengyu, with the model number of sp-3060.

[0080] The physical picture after heat storage is shown in Figure 2 .

[0081] Comparative example 2

[0082] A fluazinam · flutianil suspension agent and a preparation method thereof, the specific implementation manner is same to example 1, the difference lies in that the mass percentage of the wet dispersant is 4%, the wet dispersant is a hydrophobic group modified carboxylic acid copolymer and an alkyl aryl polyether polyol phosphate, the weight ratio is 2:2, the hydrophobic group modified carboxylic acid copolymer is purchased from Noligen, the model number is AGRILAN 788; the alkyl aryl polyether polyol phosphate is purchased from Chengyu, the model number is sp-3060.

[0083] The physical picture after heat storage is shown in Figure 3 .

[0084] Comparative example 3

[0085] A fluazinam · flutianil suspension agent and a preparation method thereof, the specific implementation manner is same to example 1, the difference lies in that the mass percentage of the wet dispersant is 2%, the wet dispersant is a polymeric carboxylic acid macromolecule, purchased from Chengyu, the model number is SP-SC3275.

[0086] The physical picture after heat storage is shown in Figure 4 .

[0087] Comparative example 4

[0088] A fluazinam · flutianil suspension agent and a preparation method thereof, the specific implementation manner is same to example 1, the difference lies in that the mass percentage of the wet dispersant is 5%, the wet dispersant is a combination of a polymeric carboxylic acid macromolecule and a sulfonate, the weight ratio is 2:3. The polymeric carboxylic acid macromolecule is purchased from Chengyu, the model number is SP-SC3275; the sulfonate is purchased from Fangzhong, the model number is DS-569.

[0089] The particle size distribution picture after heat storage is shown in Figure 7 , the particle size distribution is widened after heat storage, and the particle size increases obviously. The sieving and crystallization picture after heat storage is shown in Figure 8 , the sieving and crystallization phenomenon appears after heat storage.

[0090] Comparative example 5

[0091] A fluazinam · flutianil suspension agent and a preparation method thereof, the specific implementation manner is same to example 1, the difference lies in that the mass percentage of the thickening agent is 1.2%, the thickening agent is magnesium aluminum silicate.

[0092] The delamination and water separation picture after heat storage is shown in Figure 10 , the water separation amount is 1 / 3, which does not meet the requirements.

[0093] Comparative example 6

[0094] A fluazinam · flutianil suspension agent and its preparation method, the specific implementation manner is same with example 1, the difference is that the mass percentage of the thickening agent is 0.5%, and the thickening agent is xanthan gum.

[0095] The layered water separation photo after heat storage is shown in Figure 11 , the water separation amount is 1 / 4, which does not meet the requirement.

[0096] Comparative example 7

[0097] A fluazinam · flutianil suspension agent and its preparation method, the specific implementation manner is same with example 1, the difference is that the mass percentage of the thickening agent is 1%, and the thickening agent is a combination of magnesium aluminum silicate and xanthan gum, and the weight ratio is 1:1.

[0098] The layered water separation photo after heat storage is shown in Figure 12 , the water separation amount is 1 / 5, which does not meet the requirement.

[0099] Comparative example 8

[0100] A fluazinam · flutianil suspension agent and its preparation method, the specific implementation manner is same with example 1, the difference is that the synergist is polyvinylpyrrolidone, the model number is K30, and it is purchased from Shanghai Lingfeng Chemical.

[0101] According to a concentration of 1wt%, the suspension agent is diluted in a pigment aqueous solution (a color product can not need to add pigment). Equal amounts of 0.1g to 0.5 are dropped on the test leaf surface (green jade), and after 2h at room temperature, a rainstorm is simulated at a speed of 0.5L / min by using a spraying device, and after spraying for 20min, the spraying effect is observed, as shown in Figure 14 , the suspension agent spots on the leaf surface are very light, and the adhesion is poor.

[0102] Comparative example 9

[0103] A fluazinam · flutianil suspension agent and its preparation method, the specific implementation manner is same with example 1, the difference is that the addition amount of the grinding aid is 0.

[0104] The photo in the preparation process is shown in Figure 16 , a large amount of bubbles overflow the sand mill tank, and the defoaming agent cannot defoam.

[0105] Comparative example 10

[0106] A fluazinam · flutianil suspension agent and its preparation method, the specific implementation manner is same with example 1.

[0107] A fluazinam · flutianil suspension agent and its preparation method, the specific implementation manner is same with example 1.

[0108] Mixing and shearing dispersing deionized water, wetting dispersant, synergist, grinding aid and anti-degradation agent;

[0109] Add the pharmaceutical composition, after uniform dispersion, add the premix of magnesium aluminum silicate, xanthan gum and antifreeze, shear for 20-40 min, nano sand mill;

[0110] Sand mill to D90 particle size <0.5 μm, after sand mill, wet sieve detection, after passing, add preservative, and ethylene glycol shear for 20-40 min, to get fluazinam · flutianil suspension concentrate.

[0111] Performance test

[0112] 1. Field experiment data

[0113] 1.1 Cucumber downy mildew fluazinam · flutianil suspension concentrate field test 150g / L fluazinam · flutianil suspension concentrate for the prevention and control of cucumber downy mildew field efficacy test

[0114] Test crop: cucumber (Cucumis sativus L.), variety "Jinyou 158"

[0115] Control object: cucumber downy mildew (Pseudoperonospora cubensis)

[0116] Test start time: April 13, 2024

[0117] Test completion time: April 30, 2024

[0118] The test agent is shown in Table 1.

[0119] Table 1

[0120]

[0121]

[0122] Method of application and water volume: spray, 750 liters of water per hectare.

[0123] The test results are shown in Table 2.

[0124] Table 2

[0125]

[0126] Note: The test results in the above table are statistically analyzed by Duncan's new multiple range method, and different lowercase letters in the same column represent significant differences at the 0.05 level, and uppercase letters represent significant differences at the 0.01 level.

[0127] Conclusion: 150g / L fluazinam · oxine-copper suspension concentrate was sprayed at the initial stage of cucumber downy mildew, and the drug was applied once every 7 days, and the drug was applied twice continuously. The dosage of the preparation was 25-35mL / acre, and the dosage of the active ingredient was 56.25-78.25g / acre. It had good control effect on cucumber downy mildew.

[0128] 1.2 Fluazinam · oxine-copper suspension concentrate for controlling potato late blight Field test

[0129] Test crop: potato, variety is Holland 15

[0130] Control object: late blight [Phytophthora infestans]

[0131] Test start time: March 29, 2024

[0132] Test completion time: April 26, 2024

[0133] The test agent is shown in Table 3.

[0134] Table 3

[0135] Method of application and water amount: spraying, water amount per hectare is 750 liters.

[0136] The test results are shown in Table 4.

[0137] Table 4

[0138]

[0139] Conclusion: 150g / L fluazinam · oxine-copper suspension concentrate has good control effect on potato late blight. During the test period, the potato grew normally, and no phytotoxicity symptoms were observed. It is recommended to use 25-35mL (active ingredient 56.25-78.25g / acre) per acre, and start spraying at the initial stage of potato late blight, with an interval of 7 days, and continuously spray 3 times, which has good control effect on potato late blight.

[0140] 2. Physicochemical property test

[0141] The physicochemical property test results of Example 1 are shown in Table 5. The thermal storage condition refers to GB / T 19136-2021, and the test is conducted after storage at 54℃ for 14 days.

[0142] Table 5

[0143]

[0144]

[0145] 3. Coefficient of toxicity

[0146] The determination test of coefficient of toxicity was performed according to NY / T 1156.7-2006 Guidelines of Pesticide Indoor Biological Determination Test Fungicides Part 7: Test of Cucumber Downy Mildew by Potted Plant Method and NY / T 1156.6-2006 Guidelines of Pesticide Indoor Biological Determination Test Fungicides Part 6: Determination of Combined Action of Mixtures.

[0147] The control effect of the pharmaceutical composition of fluopicolide and flutianil on cucumber downy mildew is shown in Table 6.

[0148] Table 6

[0149]

[0150] The control effect of the pharmaceutical composition of fluopicolide and flutianil on potato late blight is shown in Table 7.

[0151] Table 7

[0152]

[0153] 4. Particle size test after grinding

[0154] The D90 and D97 particle sizes of the suspensions of Test Example 1 and Comparative Example 10 were tested three times, and the shading ratio = D90 / D97. The test results are shown in Table 8.

[0155] Table 8

[0156]

[0157] The particle sizes of the suspension prepared in Example 1 are uniform and normally distributed.

Claims

1. A pharmaceutical composition containing fluorothiazopyrone, characterized in that, It includes fluopyram and fluthiazopyr ketone, wherein the weight ratio of fluopyram to fluthiazopyr ketone is (1-2):(4-11).

2. A fluopyram·fluopyrazopyr suspension concentrate, characterized in that, The fluopyram·fluthiazopyrone suspension contains the pharmaceutical composition of claim 1.

3. The fluopyram·fluopyrazopyr acetone suspension according to claim 2, characterized in that, The raw materials for preparation include, by weight percentage, 10-40% pharmaceutical composition, 1-8% wetting and dispersing agent, 1-5% synergist, 1-3% thickener, 0.01-0.1% inhibitor, 1-5% grinding aid, 3-8% antifreeze, 0.1-0.3% preservative, and deionized water to make up to 100%.

4. The fluopyram·fluopyrazopyr suspension concentrate according to claim 3, characterized in that, The wetting and dispersing agent includes at least two of the following: hydrophobic modified carboxylic acid copolymer, alkyl aryl polyether polyol phosphate, polycarboxylic acid, phosphate ester, sulfonate, and sodium formaldehyde condensate of alkyl naphthalene sulfonate.

5. The fluopyram·fluopyrazopyr suspension concentrate according to claim 3, characterized in that, The synergist includes at least one of polyvinyl acetate, polyvinylpyrrolidone, acrylic resin polymer, or acrylic polymer.

6. The fluopyram·fluopyrazopyr suspension concentrate according to claim 3, characterized in that, The thickener comprises at least two of magnesium aluminum silicate, xanthan gum, or attapulgite.

7. The fluopyram·fluopyrazopyr suspension concentrate according to claim 6, characterized in that, The xanthan gum is added in stages, including primary xanthan gum and secondary xanthan gum.

8. A method for preparing the fluopyram·fluthiazopyr acetone suspension according to claim 7, characterized in that, Includes the following steps: Deionized water, wetting and dispersing agent, synergist, grinding aid and suppressant are mixed and sheared and dispersed. Add the drug composition, disperse it evenly, then add magnesium aluminum silicate, a premix of xanthan gum and antifreeze, shear for 20-40 minutes, and then nano-mill. The particles were sand-milled until the D90 particle size was <0.5μm. After sand milling, they were wet-sieved and tested. If they passed the test, preservatives were added, and the mixture was sheared with xanthan gum and ethylene glycol for 20-40 minutes to obtain fluopyram·fluopyrazopyr acetone suspension.

9. The method for preparing the fluopyram·fluopyrazopyr suspension according to claim 8, characterized in that, The weight ratio of primary xanthan gum to secondary xanthan gum is 1:(1-3).

10. The application of the fluopyram·fluopyrazopyr suspension according to any one of claims 2-7, characterized in that, It is used to control potato late blight and cucumber downy mildew.

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