Elaeagnus angustifolia flower oral liquid and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses an elaeagnus angustifolia flower oral liquid and a preparation method thereof. The oral liquid consists of 17 medicinal and edible medicinal materials such as russianolive flower, honey tussilago farfara and honey aster, as well as simple syrup and potassium sorbate. The preparation method comprises the following steps: soaking the medicinal materials, decocting by stages, filtering, concentrating, and carrying out alcohol precipitation according to the volume ratio of a concentrated solution to 95% ethanol of 1: 1.11; and after the ethanol is recovered, adding auxiliary materials to make the volume constant, and adjusting the pH value to 4.5-6.5. According to the preparation method of the elaeagnus angustifolia flower oral liquid, active ingredients of elaeagnus angustifolia flowers are reserved to the maximum extent through gradient alcohol precipitation and staged decoction, and the obtained oral liquid has the throat soothing effect, is clear in technological parameters and is suitable for industrial production.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a Elaeagnus angustifolia L. flower oral liquid and a preparation method thereof. BACKGROUND

[0002] The Elaeagnus angustifolia L. flower is the flower of Elaeagnus angustifolia L. of Elaeagnaceae. Elaeagnus angustifolia The Elaeagnus angustifolia L. flower has the effects of relieving cough and asthma. However, the Elaeagnus angustifolia L. flower is gradually forgotten, and the utilization of the Elaeagnus angustifolia L. flower is still limited to the stage of extracting essential oil, so it is necessary to develop deep processing and industrial production of the Elaeagnus angustifolia L. flower. SUMMARY

[0003] In order to develop deep processing and industrial production of the Elaeagnus angustifolia L. flower, the present application provides an Elaeagnus angustifolia L. flower oral liquid and a preparation method thereof. The preparation method of the Elaeagnus angustifolia L. flower oral liquid provided by the present application can maximize the retention of active ingredients of the Elaeagnus angustifolia L. flower through stage-by-stage decoction and gradient alcohol precipitation, and the obtained oral liquid has the effect of soothing throat, and the process parameters are clear and suitable for industrial production.

[0004] The present application provides a preparation method of an Elaeagnus angustifolia L. flower oral liquid, which comprises the following steps: Medicinal material pretreatment: 25% of the Elaeagnus angustifolia L. flower, 5% of honeyed Sophora flavescens Ait. flower, 7% of honeyed Radix Pulsatillae, 6% of Pericarpium Citri Reticulatae Viride, 5% of Radix Anisodi, 5% of Poria cocos, 4% of fried bitter apricot kernel, 4% of ginger and Magnolia officinalis, 3% of honeyed Ephedra, 4% of honeyed Saposhnikovia divaricata, 4% of Zhebei, 6% of honeyed Syzygium jambos leaf, 6% of compound honeyed Lilium brownii, 4% of fried Perilla frutescens, 4% of Rhodiola rosea, 4% of fried Gigeria lignin, and 4% of Glycyrrhiza uralensis Fisch. slice are selected according to the mass percentage, and the other medicinal materials are soaked in water except the Elaeagnus angustifolia L. flower; Medicinal material decoction and filtration: the soaked medicinal materials are decocted in water, boiled with a large fire, then boiled with a small fire, and then warmed with a small fire, and the Elaeagnus angustifolia L. flower is added in the warming stage; after the decoction is completed, the medicinal liquid is obtained by filtration; Medicinal liquid concentration and alcohol precipitation: the medicinal liquid is obtained by decoction, and the concentrated medicinal liquid is alcohol precipitated after 95% ethanol is added and refrigerated; Medicinal liquid dealcoholization and refining: the Elaeagnus angustifolia L. flower oral liquid is obtained by adding water to dilute the decocted and concentrated medicinal liquid-ethanol mixture after recovering ethanol, adding monosaccharide syrup and potassium sorbate solution, and constant volume.

[0005] The preparation method of the Elaeagnus angustifolia L. flower oral liquid provided by the present application can maximize the retention of active ingredients of the Elaeagnus angustifolia L. flower through stage-by-stage decoction and gradient alcohol precipitation, and the obtained oral liquid has the effect of soothing throat, and the process parameters are clear and suitable for industrial production.

[0006] Further, the duration of the warming stage is 3 min to 5 min.

[0007] Further, the target ethanol final concentration of the alcohol precipitation is 50%.

[0008] The application also provides a Elaeagnus pungens oral liquid prepared by any of the methods.

[0009] Further, the oral liquid further comprises a pharmaceutically acceptable auxiliary.

[0010] Further, the auxiliary is monosaccharide syrup or potassium sorbate.

[0011] Further, the pH value of the oral liquid is 4.5-6.5.

[0012] Further, the density of the oral liquid is 1.13 g / cm 3 -1.20 g / cm 3 .

[0013] Compared with the prior art, the application has the following beneficial effects: The application develops a new formula of Elaeagnus pungens 25%, honeyed Fritillaria walujinica 5%, honeyed Camellia japonica 7%, dried tangerine or orange peel 6%, prepared Rhizoma Pinelliae 5%, Fuling 5%, fried bitter apricot kernel 4%, ginger and magnolia officinalis 4%, honeyed Ephedra 3%, honeyed Radix Peucedani 4%, Fritillaria thunbergii Miq. 4%, honeyed Syzygium jambos leaf 6%, compound honeyed Lilium brownii 6%, fried Perilla frutescens 4%, Rhodiolae Crenulatae 4%, fried Gigeriae 4%, and Glycyrrhizae 4%. The pharmacological effects of the raw material of Elaeagnus pungens are retained through the post-adding process of Elaeagnus pungens and warm boiling at low heat. The specific proportion (the final ethanol concentration is 50%) of the volume ratio of the concentrated medicinal liquid to 95% ethanol is 1:1.11 to remove starch, mucus and other impurities in the medicinal liquid and retain flavonoids, alkaloids and other effective components in the medicinal material. The monosaccharide syrup and potassium sorbate are added to improve the taste, appearance and overall quality of the oral liquid, prolong the shelf life of the oral liquid, and provide an Elaeagnus pungens processing method which is relatively simple and easy to implement, has low equipment and production construction investment, is convenient for large-scale and industrialized production, promotes the deep processing research and development of Elaeagnus pungens and the industrialized production of Elaeagnus pungens. DETAILED DESCRIPTION

[0014] The specific embodiments of the application are described in detail below, but the protection scope of the application is not limited by the specific embodiments. Based on the examples in the application, all other examples obtained by those skilled in the art without creative labor are within the protection scope of the application. The experimental methods described in the embodiments of the application are conventional methods, and the materials and reagents used in the following examples are commercially available unless otherwise specified.

[0015] Example 1: an Elaeagnus pungens oral liquid and a preparation method thereof I. Test method 1. Selection and pretreatment of medicinal materials According to the medicinal material ratio of Table 1, select no mildew and insect holes of Elaeagnus angustifolia L., Flos Farfugii, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Praeparatum, Tuckahoe, Semen Armeniacae Amarum, Ginger Magnolia Officinalis, Ephedra Herb, Peucedanum Graveolens, Fritillaria Thunbergii Miq, Flos Syzygii, Compound Honey Lily, Perilla Frutescens L. var. Acuta, Rhodiolae, Semen Galli Sonatii Praeparatum, Glycyrrhiza Glabra, wash 17 kinds of Chinese herbal medicines, then put Flos Farfugii, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Praeparatum, Tuckahoe, Semen Armeniacae Amarum, Ginger Magnolia Officinalis, Ephedra Herb, Peucedanum Graveolens, Fritillaria Thunbergii Miq, Flos Syzygii, Compound Honey Lily, Perilla Frutescens L. var. Acuta, Semen Galli Sonatii Praeparatum, Glycyrrhiza Glabra in stainless steel decoction pot, add 25℃ purified water, make the liquid level higher than the medicinal material 5 cm, add water immediately after covering, soak for 30 min (make water molecules penetrate into medicinal material cells, promote cell swelling, effective components are more easily dissolved, facilitate subsequent decoction extraction), then drain and reserve. Elaeagnus angustifolia L. is only washed and drained for standby. Select monosaccharide syrup and potassium sorbate as auxiliary materials, wherein monosaccharide syrup has the function of correcting the taste, can cover up the bitter and astringent taste of medicinal materials themselves, make the oral liquid taste better, and monosaccharide syrup can also increase the consistency of oral liquid, make the hanging wall time of oral liquid on the bottle wall reach ≥15 s standard, improve the appearance quality and overall quality of oral liquid; potassium sorbate as a preservative can inhibit the growth and reproduction of microorganisms, prolong the shelf life of oral liquid.

[0016] Table 1 Medicinal material ratio 2, medicinal material decoction and filtration 2.1, medicinal material decoction Put the soaked Flos Farfugii, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Praeparatum, Tuckahoe, Semen Armeniacae Amarum, Ginger Magnolia Officinalis, Ephedra Herb, Peucedanum Graveolens, Fritillaria Thunbergii Miq, Flos Syzygii, Compound Honey Lily, Perilla Frutescens L. var. Acuta, Semen Galli Sonatii Praeparatum, Glycyrrhiza Glabra in stainless steel decoction pot, add 25℃ purified water to 2000 ml, then start decoction, boil the medicinal liquid in the stainless steel decoction pot to boiling, then quickly turn to medium or small fire to continue to decoct, decocting time is 20 min. When the color of medicinal liquid changes to dark brown, turn to small fire, open the pot cover to warm up, add Elaeagnus angustifolia L., the warm-up time is controlled in 5 min (Elaeagnus angustifolia L. contains volatile and heat-sensitive components, long-time decoction will cause the loss of these components, affect the efficacy and quality of oral liquid). During the whole decoction process, use wooden stirring tool to stir uniformly, ensure that the medicinal material is heated uniformly and the effective components are fully dissolved.

[0017] 2.2, medicinal liquid filtration After decoction is completed, turn off the fire, let the medicinal liquid naturally air to 25℃ normal temperature, then use glass funnel, enamel funnel and qualitative filter paper (pore size is 6 μm) to filter the medicinal liquid, improve the clarity of medicinal liquid, get pure medicinal liquid.

[0018] 3, medicinal liquid concentration and alcohol precipitation 3.1, medicinal liquid concentration The filtered pure medicinal liquid is transferred to a clean medicinal material decocting pot for boiling and concentration. When the temperature of the medicinal liquid rises to 95°C, the concentration phase begins, and the temperature of the concentrated liquid is closely monitored while using wooden stirring tools for uniform stirring. When the medicinal liquid becomes completely thick, the fire is turned off for cooling. When the temperature cools to 60°C, the state of the medicinal liquid is observed, which is in a viscous state and free of impurities (concentrated to 6.8% of the original volume), the concentration operation is stopped, and the concentrated medicinal liquid is obtained.

[0019] 3.2, Measurement of volume The concentrated medicinal liquid is carefully poured into a 500 ml measuring cylinder, the measuring cylinder is inclined at 45° during pouring, and it is slowly poured along the wall of the measuring cylinder. After pouring is completed, the measuring cylinder is left to stand for 15 min, and after the bubbles in the medicinal liquid completely disappear, the scale line of the measuring cylinder is read horizontally, and the volume of the medicinal liquid is read and recorded.

[0020] 3.3, Alcohol precipitation of medicinal liquid The volume of ethanol to be added is calculated according to the following formula: C1 x V1 = C2 (V1 + V2); In the formula, C1 is the concentration of ethanol (95%), V1 is the volume of ethanol to be added, C2 is the target final concentration of ethanol (50%), and V2 is the volume of concentrated medicinal liquid.

[0021] The calculated volume ratio of concentrated medicinal liquid to 95% ethanol is 1:1.11.

[0022] According to the calculated amount, 95% ethanol is slowly added to the concentrated medicinal liquid while stirring, and the stirring time is ≥15 min (to ensure that the ethanol and concentrated medicinal liquid are fully mixed, the impurities are uniformly dispersed in the ethanol solution, and the precipitation reaction is promoted), and the temperature of the medicinal liquid is maintained at 60°C during stirring. After the concentrated medicinal liquid and ethanol are fully mixed, a plastic wrap is added to the container opening for sealing (to prevent ethanol evaporation and external impurities from entering), and it is placed in a 4°C refrigerated environment for 24 h (in a low temperature environment, the solubility of impurities decreases, and they are more likely to precipitate, thereby achieving the purpose of removing impurities).

[0023] 4, De-alcoholization and refining of medicinal liquid 4.1, Ethanol recovery The concentrated medicinal liquid-ethanol mixture after alcohol precipitation is filtered through a filtration device to separate the precipitated impurities, and then the filtrate is transferred to a decocting device for heating and boiling to 95°C. After the fire is turned off, the medicinal liquid is cooled to ≤60°C, and the smell change is closely observed. If there is still ethanol remaining, the above operation is repeated, and the heating is continued until there is no ethanol smell in the decocting liquid, indicating that the ethanol has been completely recovered.

[0024] 4.2, Refining of medicinal liquid The medicine liquid after recovery of ethanol is divided into portions, each portion weighing 85 g. After the division, purified water is added to each portion to dilute to 125 ml, and proper stirring is performed to mix the medicine liquid uniformly. 38 g of monosaccharide syrup is added to the diluted medicine liquid, and 5 ml of 100 mg / ml potassium sorbate solution (0.5 g of potassium sorbate is dissolved in 5 ml of water at 40°C or below) is added quickly while stirring to ensure that the medicine liquid is below 40°C. After the addition of the auxiliary materials, purified water is added to the medicine liquid to 250 ml while stirring to complete the volume determination, and the sauviea flower oral liquid is obtained.

[0025] 5. Measurement of pH and density of sauviea flower oral liquid Two batches of sauviea flower oral liquid are prepared, and the pH and density of the two batches are measured.

[0026] 5.1. Measurement of pH pH test paper is used for the measurement. A piece of pH test paper is placed on a glass container, and a dropper is used to extract an appropriate amount of sauviea flower oral liquid to be detected and drop it in the middle of the pH test paper. After 3 s, a color comparison card is used to compare the color with the test paper, and the pH value is read and recorded after the pH test paper is stable.

[0027] 5.2. Measurement of density of medicine liquid The medicine liquid obtained from the two experiments is respectively placed in a clean and clean specific gravity bottle, and the mass of the specific gravity bottle is measured in advance. The volume of the medicine liquid is obtained according to the scale line on the specific gravity bottle. After the mass of the two bottles of medicine liquid is weighed, the mass of the specific gravity bottle is subtracted, and the final density of the medicine liquid is obtained by dividing the net mass of the medicine liquid by the volume of the net medicine liquid.

[0028] II. Test results Two batches of sauviea flower oral liquid are prepared, and the pH and density of the two batches are measured. The results are shown in Tables 2 and 3.

[0029] Table 2 pH values of two batches of sauviea flower oral liquid Table 3 densities of two batches of sauviea flower oral liquid The results show that the pH value of the sauviea flower oral liquid prepared by the present application is between 4.4 and 6.5, and the density is between 1.13 g / cm 3 and 1.20 g / cm 3The sand date flower oral liquid meets the quality standard, the whole sand date flower oral liquid is brownish-brown, sweet in taste, sweet and slightly bitter in taste, and has potential effects of clearing lung, resolving phlegm and relieving cough. The above results show that the sand date flower oral liquid preparation method provided by the application can prepare the sand date flower oral liquid with stable performance, can be used as a sand date flower processing method suitable for large-scale and industrial production, and provides a new scheme for sand date flower deep processing research and development and sand date flower industrial production.

[0030] Although preferred embodiments of the application have been described, those skilled in the art will be able to make additional changes and modifications without departing from the spirit and scope of the application once they have understood the basic inventive concepts.

[0031] Obviously, those skilled in the art can make various modifications and variations to the application without departing from the spirit and scope of the application. Thus, if these modifications and variations of the application fall within the scope of the claims of the application and equivalent technologies thereof, the application also intends to include these modifications and variations.

Claims

1. A method for preparing an oral liquid containing Elaeagnus angustifolia flowers, characterized in that, Includes the following steps: Pre-treatment of medicinal materials: Select 25% of jujube flowers, 5% of honey-processed coltsfoot flowers, 7% of honey-processed aster, 6% of dried tangerine peel, 5% of processed pinellia, 5% of poria cocos, 4% of stir-fried bitter almond, 4% of ginger-processed magnolia bark, 3% of honey-processed ephedra, 4% of honey-processed angelica dahurica, 4% of fritillaria thunbergii, 6% of honey-processed loquat leaves, 6% of compound honey lily bulb, 4% of stir-fried perilla seeds, 4% of rhodiola rosea, 4% of stir-fried chicken gizzard lining, and 4% of licorice tablets according to the following weight percentages for washing. Soak the other medicinal materials except for jujube flowers in water. Decoction and filtration of medicinal herbs: After soaking, add water to decoct the herbs. After boiling over high heat, reduce to medium-low heat and simmer. Then reduce to low heat and simmer gently. Add the jujube flowers during the simmering stage. After decoction, filter to obtain the medicinal liquid. Concentration and alcohol precipitation of medicinal solution: The medicinal solution is boiled to obtain a concentrated medicinal solution, and 95% ethanol is added to the concentrated medicinal solution and then refrigerated for alcohol precipitation; Alcohol removal and purification of the medicinal liquid: After recovering the ethanol from the decoction and concentrated medicinal liquid-ethanol mixture, the mixture is dispensed, diluted with water, and then mixed with monosaccharide syrup and potassium sorbate solution, and the volume is adjusted to obtain the oral liquid of the jujube flower.

2. The method for preparing the jujube flower oral liquid according to claim 1, characterized in that, The warm cooking stage lasts for 3 to 5 minutes.

3. The method for preparing the jujube flower oral liquid according to claim 1, characterized in that, The target final ethanol concentration for the alcohol precipitation is 50%.

4. The method for preparing the jujube flower oral liquid according to claim 1, characterized in that, The volume ratio of the concentrated drug solution to 95% ethanol in the alcohol precipitation is 1:1.

11.

5. A kind of oral liquid containing oleaster flowers, characterized in that, Prepared by the method described in any one of claims 1 to 4.

6. The oral liquid containing oleaster flowers according to claim 5, characterized in that, The oral liquid also includes pharmaceutically acceptable excipients.

7. The oral liquid containing oleaster flowers according to claim 6, characterized in that, The excipients are simple sugar syrup or potassium sorbate.

8. The jujube flower oral liquid according to claim 5, characterized in that, The pH value of the oral solution is 4.5~6.

5.

9. The oral liquid of oleaster flower according to claim 5, characterized in that, The density of the oral liquid is 1.13 g / cm³. 3 ~1.20 g / cm 3 .

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