Disinfectant composition and use thereof

Abstract

The present invention relates to a novel disinfectant composition comprising: A) 0.1% to less than 10% by weight, relative to the total weight of the disinfectant composition, of propionic acid; b) at least one linear or branched aliphatic or cycloaliphatic diol having from 4 to 8 carbon atoms; c) at least one surfactant selected from the group consisting of anionic surfactants, nonionic surfactants, amphoteric surfactants or glycolipid surfactants and mixtures thereof; and D) water, said disinfectant composition having a pH greater than 2.0 and less than the pKa of propionic acid, the pKa being 4.87. The composition is particularly suitable for disinfecting the breasts and nipples of animals before or after milking and for disinfecting surfaces such as open surfaces.

Description

TECHNICAL FIELD

[0001] The present invention relates to a new disinfectant composition or biocidal composition comprising propionic acid and at least one diol, particularly suitable for disinfecting the udder and teats of animals before or after milking, and for disinfecting surfaces such as open surfaces. The present invention particularly relates to a disinfectant composition in compliance with the European Regulation No. 528 / 2012 (EU), also known as "Biocidal Products Regulation", which regulates the supply of biocidal products on the market. According to Article 25 of this Regulation, a biocidal product is eligible for a simplified market authorization (SMA) procedure if the following conditions are met: - the active substances present in the biocidal product are selected from those authorized in the European Regulation No. 528 / 2012 (EU) (Annex I) and comply with all the prescribed limits, - the biocidal product does not contain substances harmful to humans and the environment, - the biocidal product does not contain nanomaterials, - the biocidal product is sufficiently effective, and - the handling and use of the biocidal product do not require personal protective equipment. BACKGROUND

[0002] Patent EP 3 677 867 B1 describes a biocidal product of plant origin comprising a mixture of at least one organic acid, a chelating agent, a non-ionic surfactant and an anionic surfactant, and a natural fragrance. All these compositions are based on lactic acid. In concentrated form, these products irritate the skin and can cause serious eye damage.

[0003] Patent FR 3 019 714 B1 describes a biodegradable concentrated biocidal formulation based on lactic acid and / or citric acid, combined with at least one sodium carboxylate and / or potassium carboxylate. According to current regulations, such formulations are classified as irritating.

[0004] In March 2022, the classification of lactic acid changed. This raw material is now labeled H314-H318 (H314: causes severe skin burns and eye damage; H318: causes serious eye damage).

[0005] The presence of lactic acid in today's biocidal products poses a labeling problem.

[0006] Indeed, obtaining a simplified market authorization (SMA) for a biocidal product requires meeting the following objectives (i) to (iv): (i) The risk phrases H314 (causes severe skin burns and eye damage), H315 (causes skin irritation), H317 (may cause anaphylactic skin reactions), H318 (causes severe eye damage), and H319 (causes severe eye irritation) should not appear on the label of biocidal products. Therefore, Annex I active substances affected by this classification should be used at concentrations that do not cause the product labeling. Personal protective equipment should not be required for handling and using biocidal products.

[0007] (ii) The active substance must be selected from the active substances listed in categories 1 to 7 of Annex I of European Regulation (EU) 528 / 2012: Category 1: Substances authorized as food additives under Regulation (EC) 1333 / 2008 and subject to restrictions (concentration must be limited to avoid classification of biocidal products under Directive 1999 / 45 / EC or Regulation 1272 / 2008). Category 2: Substances covered by Annex IV of Regulation (EC) 1907 / 2006. Category 3: Weak acids Category 4: Traditionally used substances of natural origin. Category 5: Pheromones Class 6: Substances covered by Annex I or IA of European Regulation (EU) No. 528 / 2012. Category 7: Other.

[0008] (iii) Additional ingredients present in biocidal products must be used at concentrations that do not result in the standard classification required by European Regulation No. 1272 / 2008.

[0009] (iv) The disinfection efficacy of a biocidal product must be equivalent to that of a conventional biocidal product, in accordance with the efficacy tests specified in the Biocidal Products Regulation and the Practical Guide to the Biocidal Products Regulation—Efficacy—Assessment and Evaluation (Part B+C) of Volume 2 of ECHA.

[0010] In addition, biocidal products must meet another objective (v), namely that their properties (cleaning, foaming, decorative, or rheological, depending on the intended application) must be equivalent to or superior to existing biocidal products.

[0011] The solutions proposed to meet the above-listed objectives (i) through (v) are often contradictory, making it difficult for biocidal products to simultaneously satisfy all of these requirements. For example, using active substances that are corrosive to microorganisms or in high concentrations to achieve the desired disinfection efficacy (objective (iv)) is detrimental to objective (i).

[0012] It has been discovered that by using specific ingredients, particularly by combining propionic acid with diols having linear or branched aliphatic or alicyclic chains containing 4 to 8 carbon atoms as defined below, objectives (i) to (v) listed above can be simultaneously satisfied, forming the basis of this invention. Due to the selection of these specific ingredients, the disinfectant compositions of this invention exhibit high microbial efficacy (bactericidal and yeast-killing activity) while being free from substances harmful to humans and the environment, and also free from nanomaterials (unlabeled compositions). Therefore, the disinfectant compositions of this invention can be handled without personal protective equipment.

[0013] Therefore, the disinfectant composition of the present invention meets the hygiene requirements for animal udders before or after milking for submission to SMA. It can also be used for open surface applications. Summary of the Invention

[0014] Therefore, a first object of the present invention relates to a disinfectant composition comprising: A) Propionic acid in an amount of 0.1% to less than 10% by weight relative to the total weight of the disinfectant composition. B) At least one diol having a linear or branched aliphatic or alicyclic chain containing 4 to 8 carbon atoms, preferably 5 to 8 carbon atoms. C) At least one surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants, glycolipid surfactants, and mixtures thereof, and D) Water, The disinfectant composition has a pH greater than 2.0 and less than 4.87.

[0015] A second object of the invention relates to the use of the compositions described above for disinfecting the udder and teats of animals before or after milking. The use of the compositions for surface disinfection also constitutes part of this invention.

[0016] Another object of the present invention relates to a method for disinfecting the udder and teats of an animal before or after milking, the method comprising at least the step of applying a composition according to the invention to the udder and teats of the animal before and / or after milking the animal.

[0017] Finally, the ultimate goal is a method for disinfecting surfaces, which includes the step of applying the composition according to the invention to the surface to be disinfected. Detailed Implementation

[0018] Therefore, the first object of the present invention relates to a disinfectant composition comprising: A) propionic acid of the formula CH3CH2COOH in an amount of 0.1% to less than 10% by weight relative to the total weight of the disinfectant composition; B) at least one diol having a linear or branched aliphatic or alicyclic chain containing 4 to 8 carbon atoms, preferably 5 to 8 carbon atoms; C) at least one surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants, glycolipid surfactants, and mixtures thereof; and D) water. The disinfectant composition has a pH value greater than 2.0 and less than 4.87, with the limit of 4.87 corresponding to the pKa value of propionic acid.

[0019] The amount of propionic acid A present in the composition may advantageously be from 0.1% to 5% by weight, more preferably from 1% to 5% by weight, relative to the total weight of the disinfectant composition.

[0020] The diol B present in the composition is advantageously selected from 1,2-hexanediol, 2-methyl-1,3-propanediol, 2,3-butanediol (especially meso-2,3-butanediol), isopentylene glycol, 1,6-hexanediol, 1,2-pentanediol, 1,4-cyclohexanediol and mixtures thereof, preferably selected from 1,2-hexanediol, 1,6-hexanediol, 2,3-butanediol and mixtures thereof, and more preferably selected from 1,2-hexanediol, 1,6-hexanediol and mixtures thereof.

[0021] In another specific embodiment, diol B) is an ortho-diol containing a linear or branched aliphatic or alicyclic chain having 4 to 6 carbon atoms, preferably 1,2-hexanediol, 2,3-butanediol and mixtures thereof, more preferably 1,2-hexanediol.

[0022] The amount of diol B is advantageously 0.1% to less than 10% by weight, preferably 1% to 8% by weight, relative to the total weight of the disinfectant composition.

[0023] Advantageously, the disinfectant composition of the present invention does not contain primary alcohols.

[0024] The disinfectant composition of the present invention further comprises at least one surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants, and glycolipid surfactants and mixtures thereof. Surfactant C) is advantageously selected from anionic surfactants, nonionic surfactants, and mixtures thereof.

[0025] When surfactant C) is an anionic surfactant, it is advantageously selected from alkyl sulfonates, olefin sulfonates, paraffin sulfonates, glucoside sulfonates, alkyl sulfates, alkyl ether sulfates, alkyl taurines, acyl glutamates, alkyl ether carboxylic acids and their salts, and mixtures thereof, preferably from sodium lauryl glucoside hydroxypropyl sulfonate, sodium decyl glucoside hydroxypropyl sulfonate, sodium 2-ethylhexyl sulfate, sodium n-octyl sulfate, sodium lauryl sulfate, sodium lauryl ether sulfate, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium octyl glutamate, octyl ether-9 carboxylic acid, optionally mixed with butanol ether-2 carboxylic acid, lauryl ether-11 carboxylic acid, and mixtures thereof. The most preferred anionic surfactants are sodium n-octyl sulfate, sodium 2-ethylhexyl sulfate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium octyl glutamate, and mixtures thereof.

[0026] When surfactant C) is a nonionic surfactant, it is advantageously selected from sorbitol esters, glycerol esters, polyglycerol esters, alkyl polyglucosides, alkyl polypentosides, alkanoyl lactyl lactate, ethoxylated alcohols, ethoxylated castor oil, and mixtures thereof, preferably selected from sorbitol monolaurate, sorbitol monooleate, sorbitol sesquicaprylate, glyceryl caprylate / decanoate, polyglycerol-3 caprylate, polyglycerol-4 caprylate, and C 10 -C 16 Alkyl polyglucosides, C5 and C 10 -C 12 Pentyl xyloside, lauryl lactyllactate, ethoxylated C 10 Alcohols (preferably having 6 EO atoms), ethoxylated castor oil, and mixtures thereof. The most preferred nonionic surfactants are sorbitan monooleate, polyglycerol-4-decanoate, and C... 10 -C 16 Alkyl polyglucosides, ethoxylated castor oil (preferably having 33 EOs), and mixtures thereof.

[0027] Within the meaning of this invention, the term "alkyl" refers to a saturated linear or branched aliphatic hydrocarbon group, preferably C1-C2. 20 More preferably C1-C 12 The term "branching" means that at least one lower alkyl group (such as methyl or ethyl) is carried by a linear alkyl chain.

[0028] When surfactant C) is an amphoteric surfactant, it is advantageously selected from sodium lauroylamphoteric acid, sodium 2-ethylhexyliminodipropionate, and mixtures thereof.

[0029] Surfactant C) advantageously accounts for 0.1% to less than 10% by weight, preferably 0.1% to 5% by weight, relative to the total weight of the disinfectant composition.

[0030] The disinfectant composition also contains water (D), which preferably accounts for 40 to 99.5% by weight, more preferably 75 to 95% by weight, relative to the total weight of the disinfectant composition.

[0031] In addition to components A) to D) above, the disinfectant composition according to the invention may further contain at least one humectant E). The humectant E) is preferably selected from polyols other than glycol B), hyaluronic acid and its derivatives, alginate, urea and mixtures thereof, more preferably from polyols other than glycol B), such as those selected from glycerin, propylene glycol, sorbitol, xylitol, erythritol, mannitol, xylose and mixtures thereof. Glycerin, propylene glycol and mixtures thereof are the most preferred humectant E).

[0032] The humectant E) is advantageously present in a proportion of 0% to 30% by weight, preferably 1% to 20% by weight, relative to the total weight of the disinfectant composition.

[0033] The disinfectant composition of the present invention may further comprise at least one pH adjuster (F), the nature and amount of which are selected such that the pH of the composition is greater than 2.0 and less than the pKa of propionic acid, which is 4.87. The pH adjuster of the present invention may be: Acids such as hydrochloric acid and sulfuric acid, with hydrochloric acid being preferred. - Or bases such as sodium hydroxide and potassium hydroxide, with sodium hydroxide being preferred.

[0034] The disinfectant composition of the present invention has a pH greater than 2.0 and less than the pKa of propionic acid, which is 4.87. A pH below 2.0 automatically classifies the disinfectant composition as H318 (causing severe eye damage). In a preferred embodiment of the present invention, the disinfectant composition has a pH greater than 2.1 and less than 4.0, more preferably greater than 2.3 and less than 3.5.

[0035] The pH adjuster (F) advantageously accounts for 0 to 1% by weight, preferably 0.01% to 0.5% by weight, and more preferably 0.01% to 0.25% by weight, relative to the total weight of the disinfectant composition.

[0036] The disinfectant composition of the present invention may further comprise one or more excipients, said excipients being selected from: - Dyes, preferably edible dyes, such as E104 (quinoline yellow), E110 (sunset yellow), E131 (patent blue V), E133 (brilliant blue FCP), and mixtures thereof. - Opacifier, preferably a copolymer of acrylic-styrene and styrene-polyvinylpyrrolidone (PVP). - Thickeners, preferably natural gums such as cellulose, xanthan gum, gum arabic, guar gum, and diutane gum and mixtures thereof.

[0037] The disinfectant composition of the present invention also has the advantage of not containing nanomaterials.

[0038] The disinfectant composition of the present invention is ready-to-use.

[0039] The disinfectant composition of the present invention is advantageously in liquid, gel, or foam form. Therefore, it can be applied by soaking or spraying.

[0040] Another object of the present invention is the use of the disinfectant composition according to the invention for disinfecting the udder and teats of animals before and / or after milking.

[0041] Another use of the disinfectant composition of the present invention is for disinfecting surfaces, preferably open surfaces.

[0042] The disinfection method is also part of this invention.

[0043] According to one embodiment, the present invention relates to a method for disinfecting the udder and teats of an animal before and / or after milking, the method comprising the following steps: (i) Before and / or after milking the animal, apply the disinfectant composition according to the invention to the animal's udder and teats, then (ii) Optionally, the disinfectant composition is removed from the animal's udder and nipples, preferably by wiping.

[0044] In step (i), the disinfectant composition can be applied manually or automatically. In the latter case, it can be applied using a milking robot or an automated system.

[0045] When applying step (i) before milking an animal, the contact time of the disinfectant composition with the animal's udder and nipples is preferably 30 seconds to 3 minutes, more preferably 30 seconds to 1 minute and 30 seconds.

[0046] When applying step (i) after milking an animal, the contact time of the disinfectant composition with the animal's udder and teats is preferably less than 5 minutes, and more preferably at least 30 seconds.

[0047] In step (ii), the disinfectant composition can be removed by manual wiping (using paper or a separate cloth) or by any other automated system (milking robot).

[0048] When the method of disinfecting the udder and teats of an animal according to the present invention is performed before milking, the disinfectant composition is removed according to option (ii).

[0049] When the method for disinfecting the udder and teats of an animal according to the invention is performed after milking, the disinfectant composition is not removed according to option (ii).

[0050] According to another embodiment, the present invention relates to a method for disinfecting a surface, comprising the step of applying a disinfectant composition according to the invention to the surface to be disinfected, preferably to an open surface. The application step can be performed manually or automatically. The disinfectant composition can be applied by spraying or as foam. Furthermore, a rinsing and / or drying step may follow the application step.

[0051] In addition to the above-described arrangements, the present invention also includes other arrangements which will appear in the following additional description, relating to the prior art and the preparation of disinfectant compositions according to the present invention.

[0052] Example: The disinfectant compositions shown in the examples were prepared at room temperature, and the ingredients were added in the order detailed in the formulations described below, with magnetic or electric stirring at 300 rpm. All percentages shown are by weight.

[0053] The properties of the disinfectant composition are then evaluated according to the following efficacy tests as specified in the Biocidal Products Regulation and the Practical Guide to the Biocidal Products Regulation - ECHA, Volume 2, Efficacy - Assessment and Evaluation (Part B+C): Phase 2, Step 1: Suspension Test EN 1656 (September 2019): Quantitative suspension test for evaluating the bactericidal activity of chemical preservatives and disinfectants used in the veterinary field.

[0054] The test method includes dilution-neutralization. Using a neutralizing agent, this method stops the biocidal activity of the product at the end of the test contact time.

[0055] The neutralizing agent used consisted of 3.0% saponins, 3.0% polysorbate 80, 0.3% lecithin, 0.5% sodium thiosulfate, and 0.1% L-histidine (in percentages expressed as m / V), with the volume made up with distilled water. The neutralizing agent was sterilized at 121°C for 15 min.

[0056] The strain tested was Staphylococcus aureus ( Staphylococcus aureus (DMS 799), Escherichia coli ( Escherichia coli (DMS 682) and Streptococcus lactis ( Streptococcus uberis (DMS 20569).

[0057] Dilute the formulation in distilled water to 1% (non-effective concentration), 50%, and 80% (percentage expressed as V / V).

[0058] The test was conducted at 30 ± 1°C. The contact time for the product before milking was 1 minute ± 5 seconds, and the contact time for the product after milking was 5 minutes ± 10 seconds.

[0059] The experiment was conducted in the presence of interfering substances: 3 g / L bovine albumin for the product before milking, which is equivalent to low-level contamination conditions (sterilization by membrane filtration with a porosity of 0.45 µm), and 10 g / L skim milk powder for the product after milking (sterilization at 121°C for 5 min).

[0060] After neutralization, the test dilution was placed on tryptone soybean agar (TSA).

[0061] The strain was incubated at 37 ± 1°C for two cycles between 20 and 24 hours.

[0062] The counting technique is depth counting (colony counting).

[0063] Under test conditions, the test product must show a reduction of at least 5 log decimal places.

[0064] EN 1657 (May 2016): Quantitative suspension test for evaluating the fungicidal or yeasticidal activity of chemical preservatives and disinfectants used in the veterinary field.

[0065] The test method includes dilution-neutralization. Using a neutralizing agent, this method stops the biocidal activity of the product at the end of the test contact time.

[0066] The neutralizing agent used consisted of 3.0% saponins, 3.0% polysorbate 80, 0.3% lecithin, 0.5% sodium thiosulfate, and 0.1% L-histidine (in percentages expressed as m / V), with the volume made up with distilled water. The neutralizing agent was sterilized at 121°C for 15 min.

[0067] The strain tested was Candida albicans ( Candida albicans (DMS 1386).

[0068] Dilute the 125% concentrate in distilled water to 0.8% (non-effective concentration), 64%, and 80% (percentages expressed as V / V).

[0069] The test was conducted at 30 ± 1°C. The contact time for the product before milking was 1 minute ± 5 seconds, and the contact time for the product after milking was 5 minutes ± 10 seconds.

[0070] The experiment was conducted in the presence of interfering substances: 3 g / L bovine albumin for the product before milking, which is equivalent to low-level contamination conditions (sterilization by membrane filtration with a porosity of 0.45 µm), and 10 g / L skim milk powder for the product after milking (sterilization at 121°C for 5 min).

[0071] After neutralization, the test dilution was placed on malt extract agar (MEA). The strain was incubated at 30 ± 1°C for two cycles between 20 and 24 hours.

[0072] The counting technique is depth counting (colony counting).

[0073] Under the test conditions, the test product must show a reduction of at least 4 log decimal places.

[0074] Phase 2, Step 2: Surface Testing Draft Standard EN 17422 (June 2020): Quantitative surface tests for evaluating nipple disinfectants used in the veterinary field – specific tests for bactericidal activity.

[0075] The test method includes dilution-neutralization. Using a neutralizing agent, this method stops the biocidal activity of the product at the end of the test contact time.

[0076] The neutralizing agent used consisted of 3.0% saponins, 3.0% polysorbate 80, 0.3% lecithin, 0.5% sodium thiosulfate, and 0.1% L-histidine (in percentages expressed as m / V), with the volume made up with distilled water. The neutralizing agent was sterilized at 121°C for 15 min.

[0077] The strains tested were Staphylococcus aureus (DMS 799) and Escherichia coli (DMS 682).

[0078] Test the pure (100%) formulation and dilute the formulation in distilled water to 1% (non-effective concentration) and 80% (percentage expressed as V / V).

[0079] The test was conducted at 30 ± 1°C. The contact time for the product before milking was 1 minute ± 5 seconds, and the contact time for the product after milking was 5 minutes ± 10 seconds.

[0080] The experiment was conducted in the presence of interfering substances: 3 g / L bovine albumin for the product before milking, which is equivalent to low-level contamination conditions (sterilization by membrane filtration with a porosity of 0.45 µm), and 10 g / L skim milk powder for the product after milking (sterilization at 121°C for 5 min).

[0081] The test surface is 4 cm.2 (2 cm × 2 cm) Vitro Skin synthetic skins. They were aseptically cut and then placed in a rehydration chamber containing 300 mL of 15% glycerol solution at room temperature for a duration between 16 and 24 hours. 50 µL of the mixture [strain + interfering substance] was applied to the skin and then placed in an incubator at 30 ± 1°C for 15 min.

[0082] The skin was then immersed in 10 mL of the test solution for 30 seconds, drained, and placed in an incubator at 30 ± 1°C (test temperature) for a continuous reduction of the 30-second limit of contact time.

[0083] It was then transferred to a neutralizing agent and placed on tryptone soybean agar (TSA).

[0084] The strain was incubated at 37 ± 1°C for two cycles, between 20 and 24 hours.

[0085] The counting technique is depth counting (colony counting).

[0086] Products tested under conditions prior to milking must show a reduction of at least 3 log decimal places.

[0087] Products tested under post-milking conditions must show a reduction of at least 4 log decimal places.

[0088] EN 13697 + A1 (July 2019): Quantitative test for nonporous surfaces, used to evaluate the bactericidal and / or fungicidal activity of chemical disinfectants used in the food industry, other industries, households and community sectors. The test method does not involve mechanical action or requirements (Phase 2, Step 2).

[0089] The test method includes dilution-neutralization. Using a neutralizing agent, this method stops the biocidal activity of the product at the end of the test contact time.

[0090] The neutralizing agent used consisted of 3.0% saponins, 3.0% polysorbate 80, 0.3% lecithin, 0.5% sodium thiosulfate, and 0.1% L-histidine (in percentages expressed as m / V), with the volume made up with distilled water. The neutralizing agent was sterilized at 121°C for 15 min.

[0091] The tested strain was Candida albicans (DMS 1386). The strain was incubated at 30 ± 1°C for 48 hours.

[0092] The test was conducted at 20 ± 1°C. The contact time was 5 minutes ± 10 seconds and 10 minutes ± 10 seconds.

[0093] The experiment was conducted in the presence of the following interfering substance: 0.3 g / L bovine albumin, corresponding to clean conditions (sterilization by filtration through a membrane with a porosity of 0.45 µm).

[0094] The test surface was a 304 stainless steel disc (2 cm in diameter), with two surfaces machined to grade 2b (cleaned in 5% DECON solution for 60 minutes, rinsed with distilled water for 10 seconds, sterilized in a bath containing 70% (V) isopropanol for 15 minutes, and then dried under laminar flow).

[0095] Place 50 µL of the mixture [strain + interfering substance] on a disc, and then place the disc in an incubator at 37 ± 1°C until visibly dry. Drying should not exceed 1 hour.

[0096] Apply 100 µL of the test product to cover the dried film. Maintain the surface at 20°C for the specified contact time.

[0097] Transfer the surface to a neutralizing medium to immediately neutralize the disinfectant.

[0098] The number of surviving organisms that can be recovered from the surface can be quantitatively determined.

[0099] Microorganisms are separated from the disc by contacting and rubbing the surface with glass beads of 3 mm in diameter.

[0100] They also measured the yeast count on surfaces treated with hard water instead of disinfectants and calculated the reduction in the number of live cells due to the product by using the difference.

[0101] For bactericides, the submitted product must show a reduction of at least 4 log decimal places under the test conditions.

[0102] For yeast-killing agents, the submitted product must show a reduction of at least 3 log decimal places under the test conditions.

[0103] Example 1: A disinfectant composition for post-milking udder hygiene according to the present invention The composition of Example 1 (wt%): 2% propionic acid (an active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 6% 1,2-hexanediol, 8% glycerin, 1% castor oil 33 EO, 0.001% ready-to-use dye mixture, which contains 90% E102 (tartrazine) and 10% E131 (patent blue V). 0.008% E102 dye (lemon yellow). Adjust the pH to 3.5 with 0.08% NaOH (50%). An appropriate amount of water.

[0104] Classification of the compositions in Example 1: Specific concentration limits for propionic acid: If the active ingredient = 100%: H314 (causes severe skin burns and eye damage) - H318 (causes severe eye damage) - H335 (may cause respiratory irritation) - H226 (flammable liquid and vapor).

[0105] If the active ingredient is between 25% and 100%: H314 (causes severe skin burns and eye damage) - H318 (causes severe eye damage) → calculate the specific concentration limit for H314 and H318 as 25%.

[0106] If the active ingredient is between 10% and 25% => H315 (causes skin irritation) - H319 (causes severe eye irritation) → calculate the specific concentration limit for H315 and H319 as 10.

[0107] If the active ingredient is ≥ 10% => H335 (may cause respiratory irritation).

[0108] Specific concentration limits for sodium hydroxide: If the active ingredient = 100%: H314 (causes severe skin burns and eye damage) - H290 (may be corrosive to metals).

[0109] If the active ingredient is between 2% and 100%: H314 (causes severe skin burns and eye damage) - H318 (causes severe eye damage) → calculate the specific concentration limit for H314 and H318 as 2.

[0110] If the active ingredient content is between 0.5% and 2%: H315 (causes skin irritation) - H319 (causes severe eye irritation) → calculate the specific concentration limit for H315 and H319 as 0.5%.

[0111] Eye calculation: H318: Only propionic acid and sodium hydroxide solution should be considered. 2 / 25 + 0.04 / 2 = 0.1 < 1 → The mixture is not classified as H318.

[0112] H319: Only propionic acid, sodium hydroxide, and 1,2-hexanediol should be considered. 2 / 10 + 0.04 / 0.5 + 6 / 10 = 0.88 < 1 → The mixture is not classified as H319.

[0113] Skin calculation: H314: Only propionic acid and sodium hydroxide should be considered. 2 / 25 + 0.04 / 2 = 0.1 < 1 → The mixture is not classified as H314.

[0114] H315: Only propionic acid and sodium hydroxide should be considered. 2 / 10 + 0.04 / 0.5 = 0.28 < 1 → The mixture is not classified as H315.

[0115] Products are not categorized.

[0116] Disinfection effect: Phase 2, Step 1: EN 1656: 5 min, 30°C, 10 g / L skim milk, effective against Staphylococcus aureus limiting microorganisms: 80%.

[0117] EN 1657: 5 min, 30 °C, 10 g / L skim milk, 100% effective against Candida albicans.

[0118] Phase 2, Step 2: EN 17422: 5 min, 30°C, 10 g / L skim milk, 100% effective against Staphylococcus aureus limiting microorganisms.

[0119] These results demonstrate that the composition of Example 1 is effective and does not contain any substances or nanomaterials harmful to humans and the environment. Therefore, the composition meets SMA qualification requirements.

[0120] The composition of Example 1 was then subjected to a mammary hygiene test: the composition was sprayed onto the animal's teats using a standard 1-L manual sprayer (supplier: CNTT). No unpleasant odor was detected during milking.

[0121] Example 2: Disinfectant composition for post-milking udder hygiene according to the present invention Composition of Example 2 (wt%): 2% propionic acid (an active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 4% 1,2-hexanediol, 8% glycerin, 1% sodium octyl sulfate, 0.001% ready-to-use dye mixture, which contains 90% E102 (tartrazine) and 10% E131 (patent blue V). 0.008% E102 dye (lemon yellow). Adjust the pH to 2.8 with 0.02% HCl (33%). An appropriate amount of water.

[0122] Classification of the compositions in Example 2: Specific concentration limits for propionic acid: See Example 1.

[0123] Specific concentration limits for sodium n-octyl sulfate: If the active ingredient is ≥ 20%: H318 (causing serious eye damage) → calculate the specific concentration limit for H318 as 20.

[0124] If the active ingredient is between 10% and 20%: H319 (causes serious eye damage) → calculate the specific concentration limit for H319 as 10.

[0125] Specific concentration limits for hydrochloric acid: If the active ingredient = 100%: H314 (causes severe skin burns and eye damage) - H318 (causes severe eye damage) - H335 (may cause respiratory irritation) - H290 (may be corrosive to metals).

[0126] If the active ingredient is between 25% and 100%: H314 (causes severe skin burns and eye damage) - H318 (causes severe eye damage), H335 (may cause respiratory irritation) → calculate the specific concentration limit for H314 and H318 as 25%.

[0127] If the active ingredient is between 10% and 25%: H315 (causes skin irritation) - H319 (causes severe eye irritation), H335 (may cause respiratory irritation) → calculate the specific concentration limit for H315 and H319 as 10.

[0128] Eye calculation: H318: Only propionic acid, sodium n-octyl sulfate, and hydrochloric acid should be considered. 2 / 25 + 1 / 20 + 0.007 / 25 = 0.13 < 1 → The mixture is not classified as H318.

[0129] H319: Only propionic acid, sodium n-octyl sulfate, hydrochloric acid, and 1,2-hexanediol should be considered. 2 / 10 + 1 / 10 + 0.007 / 10 + 4 / 10 = 0.7 < 1 → The mixture is not classified as H319.

[0130] Skin calculation: H314: Only propionic acid and hydrochloric acid should be considered. 2 / 25 + 0.007 / 25 = 0.08 < 1 → The mixture is not classified as H314.

[0131] H315: Only propionic acid, sodium n-octyl sulfate, and hydrochloric acid should be considered. 2 / 10 + 1 / 10 + 0.007 / 10 = 0.3 < 1 → The mixture is not classified as H315.

[0132] Products are not categorized.

[0133] Disinfection effect: Phase 2, Step 1: EN 1656: Skim milk at 30 °C for 5 min, 30 °C, and 10 g / L is 50% effective against Staphylococcus aureus, Escherichia coli, and Streptococcus lactis.

[0134] EN 1657: 5 min, 30 °C, 10 g / L skim milk, 100% effective against Candida albicans.

[0135] Phase 2, Step 2: EN 17422: 5 min, 30 °C, 10 g / L skim milk, 100% effective against Staphylococcus aureus and Escherichia coli.

[0136] These results demonstrate that the composition of Example 2 is effective and does not contain any substances or nanomaterials harmful to humans and the environment. Therefore, the composition meets SMA qualifications.

[0137] The composition of Example 2 was then subjected to a mammary hygiene test: the composition was sprayed onto the animal's teats using a standard 1-L manual sprayer (supplier: CNTT). No unpleasant odor was detected during milking. Slight foaming was formed during application, which helped retain the product on the teats and made the applied product well visible. Good distribution of the product on the teats was observed.

[0138] Example 3: Disinfectant composition for udder hygiene before milking according to the present invention Composition of Example 3 (wt%): 2% propionic acid (an active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 6% 1,2-hexanediol, 8% glycerin, 5% xylitol, 1% sodium octyl sulfate, 0.8% sodium lauryl glucoside hydroxypropyl sulfonate 0.009% E104 dye (quinoline yellow). 0.0001% E133 dye (brilliant blue). Adjust the pH to 2.3 with 0.12% HCl (33%). An appropriate amount of water.

[0139] Classification of the compositions in Example 3: Specific concentration limits for propionic acid: See Example 1.

[0140] Specific concentration limits for sodium octyl sulfate and hydrochloric acid: See Example 2.

[0141] Eye calculation: H318: Only propionic acid, sodium n-octyl sulfate, and hydrochloric acid should be considered. 2 / 25 + 1 / 20 + 0.04 / 2 = 0.14 < 1 → The mixture is not classified as H318.

[0142] H319: Only propionic acid, sodium n-octyl sulfate, hydrochloric acid, and 1,2-hexanediol should be considered. 2 / 10 + 1 / 10 + 0.04 / 10 + 6 / 10 = 0.9 < 1 → The mixture is not classified as H319.

[0143] Skin calculation: H314: Only propionic acid and hydrochloric acid should be considered. 2 / 25 + 0.04 / 25 = 0.08 < 1 → The mixture is not classified as H314.

[0144] H315: Only propionic acid, hydrochloric acid, and sodium octyl sulfate should be considered. 2 / 10 + 0.04 / 10 + 1 / 10 = 0.3 < 1 → The mixture is not classified as H315.

[0145] Products are not categorized.

[0146] Disinfection effect: Phase 2, Step 1: EN 1656: 1 min, 30°C, 3 g / L bovine albumin, effective against Staphylococcus aureus restrictive microorganisms: 80% effective.

[0147] EN 1657: 1 min, 30°C, 3 g / L bovine albumin, 100% effective against Candida albicans. Phase 2, Step 2: EN 17422: 1 min, 30°C, 3 g / L bovine albumin, 100% effective against Staphylococcus aureus restrictive microorganisms.

[0148] These results demonstrate that the composition of Example 3 is effective and does not contain any substances or nanomaterials harmful to humans and the environment. Therefore, the composition meets SMA qualifications.

[0149] The composition of Example 3 was then subjected to a mammary hygiene test: the composition was sprayed onto the animal's teats using a standard 1-L manual sprayer (supplier: CNTT). No unpleasant odor was detected during milking. Slight foaming was formed during application, which helped retain the product on the teats and made the applied product well visible. Good distribution and cleanliness of the product on the teats were observed.

[0150] Example 4: Disinfectant composition for post-milking udder hygiene according to the present invention Composition of Example 4 (wt%): 1% propionic acid (an active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 7% 1,2-hexanediol, 1% sodium 2-ethylhexyliminodipropionate, Adjust the pH to 2.3 with 0.77% HCl (33%). An appropriate amount of water.

[0151] Classification of the compositions in Example 4: Specific concentration limits for propionic acid: See Example 1.

[0152] Specific concentration limits for hydrochloric acid: See Example 2.

[0153] Eye calculation: H318: Only propionic acid and hydrochloric acid should be considered. 1 / 25 + 0.25 / 25 = 0.05 < 1 → The mixture is not classified as H318.

[0154] H319: Only propionic acid, hydrochloric acid, and 1,2-hexanediol should be considered. 1 / 10 + 0.25 / 10 + 7 / 10 = 0.83 < 1 → The mixture is not classified as H319.

[0155] Skin calculation: H314: Only propionic acid and hydrochloric acid should be considered. 1 / 25 + 0.25 / 25 = 0.05 < 1 → The mixture is not classified as H314.

[0156] H315: Only propionic acid and hydrochloric acid should be considered. 1 / 10 + 0.25 / 10 = 0.13 < 1 → The mixture is not classified as H315.

[0157] Products are not categorized.

[0158] Disinfection effect: Phase 2, Step 1: EN 1656: 5 min, 30°C, 10 g / L skim milk, effective against Staphylococcus aureus limiting microorganisms: 80%.

[0159] EN 1657: 5 min, 30°C, 10 g / L skim milk, 100% effective against Candida albicans.

[0160] Phase 2, Step 2: EN 17422: 5 min, 30°C, 10 g / L skim milk, 100% effective against Staphylococcus aureus limiting microorganisms.

[0161] These results demonstrate that the composition of Example 4 is effective and does not contain any substances or nanomaterials harmful to humans and the environment. Therefore, the composition meets SMA qualification requirements.

[0162] Example 5: Disinfectant composition for breast hygiene according to the present invention Composition of Example 5 (wt%): 2% propionic acid (an active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 6% 1,2-hexanediol, 8% glycerin, 5% xylitol, 1% sodium octyl sulfate, 0.8% sodium lauryl glucoside hydroxypropyl sulfonate Adjust the pH to 2.3 with 0.12% HCl (33%). An appropriate amount of water.

[0163] Disinfection effect: Phase 2, Step 1: EN 1657: 1 min, 30°C, 3 g / L bovine albumin, 100% effective against Candida albicans (reduction >4.39 log, 4 log required).

[0164] Comparative Example 1: Lactic acid-based disinfectant composition compared with Example 1 Prepare a composition that compares with the composition of Example 1, wherein lactic acid is used instead of propionic acid.

[0165] Composition of Comparative Example 1 (wt%): 2% lactic acid, 6% 1,2-hexanediol, 8% glycerin, 1% castor oil 33 EO, 0.001% ready-to-use dye mixture, which contains 90% E102 (tartrazine) and 10% E131 (patent blue V). 0.008% E102 dye (lemon yellow). Adjust the pH to 3.5 with 0.28% sodium hydroxide. An appropriate amount of water.

[0166] Classification of the compositions in Comparative Example 1: Eye calculation: H318: Only propionic acid and sodium hydroxide solution should be considered. 2 / 3 + 0.28 / 2 = 0.81 < 1 → The mixture is not classified as H318.

[0167] H319: Only lactic acid, sodium hydroxide, and 1,2-hexanediol should be considered. 2 / 1 + 0.28 / 0.5 + 6 / 10 = 3.16 > 1 → The mixture is classified as H319.

[0168] Skin calculation: H314: Only lactic acid and sodium hydroxide solution should be considered. 2 / 5 + 0.28 / 2 = 0.54 < 1 → The mixture is not classified as H314.

[0169] H315: Only lactic acid and sodium hydroxide solutions should be considered. 2 / 1 + 0.28 / 0.5 = 2.56 > 1 → The mixture is classified as H315.

[0170] Therefore, the product is classified as not meeting the aforementioned objective (iii) (it will not be classified according to the standards of European Regulation No. 1272 / 2008).

[0171] Comparative Example 2: Lactic acid-based disinfectant composition compared with Example 2 Prepare a composition to compare with the composition of Example 2, wherein lactic acid is used instead of propionic acid.

[0172] Composition of Comparative Example 2 (wt%): 2% lactic acid, 4% 1,2-hexanediol, 8% glycerin, 1% sodium octyl sulfate, 0.001% ready-to-use dye mixture, which contains 90% E102 (tartrazine) and 10% E131 (patent blue V). 0.008% E102 dye (lemon yellow). Adjust the pH to 2.8 with 0.08% sodium hydroxide. An appropriate amount of water.

[0173] Classification of the compositions in Comparative Example 2: Eye calculation: H318: Only lactic acid, sodium n-octyl sulfate, and sodium hydroxide should be considered. 2 / 3 + 1 / 20 + 0.08 / 2 = 0.76 < 1 → The mixture is not classified as H318.

[0174] H319: Only lactic acid, sodium n-octyl sulfate, sodium hydroxide, and 1,2-hexanediol should be considered. 2 / 1 + 1 / 10 + 0.08 / 0.5 + 4 / 10 = 2.66 > 1 → The mixture is classified as H319.

[0175] Skin calculation: H314: Only lactic acid and sodium hydroxide should be considered. 2 / 5 + 0.08 / 2 = 0.44 < 1 → The mixture is not classified as H314.

[0176] H315: Only lactic acid, sodium n-octyl sulfate, and sodium hydroxide should be considered. 2 / 1 + 1 / 10 + 0.08 / 0.5 = 2.26 > 1 → The mixture is classified as H315.

[0177] Therefore, the product is classified as not meeting the aforementioned objective (iii) (it will not be classified according to the standards of European Regulation No. 1272 / 2008).

[0178] Comparative Example 3: Lactic acid-based disinfectant composition compared with Example 3 Prepare a composition to compare with the composition of Example 3, wherein lactic acid is used instead of propionic acid.

[0179] Composition of Comparative Example 3 (wt%): 2% lactic acid, 6% 1,2-hexanediol, 8% glycerin, 5% xylitol, 1% sodium octyl sulfate, 0.8% sodium lauryl glucoside hydroxypropyl sulfonate 0.009% E104 dye (quinoline yellow). 0.0001% E133 dye (brilliant blue). Adjust the pH to 2.3 with 0.04% HCl (33%). An appropriate amount of water.

[0180] Classification of the compositions in Comparative Example 3: Eye calculation: H318: Only lactic acid, sodium n-octyl sulfate, and hydrochloric acid should be considered. 2 / 3 + 1 / 20 + 0.013 / 25 = 0.72 < 1 → The mixture is not classified as H318.

[0181] H319: Only lactic acid, sodium n-octyl sulfate, hydrochloric acid, and 1,2-hexanediol should be considered. 2 / 1 + 1 / 10 + 0.013 / 10 + 6 / 10 = 2.7 > 1 → The mixture is classified as H319.

[0182] Skin calculation: H314: Only lactic acid and hydrochloric acid should be considered. 2 / 5 + 0.013 / 25 = 0.40 < 1 → The mixture is not classified as H314.

[0183] H315: Only lactic acid, hydrochloric acid, and sodium octyl sulfate should be considered. 2 / 1 + 0.013 / 10 + 1 / 10 = 2.1 > 1 → The mixture is classified as H315.

[0184] Therefore, the product is classified as not meeting the aforementioned objective (iii) (it will not be classified according to the standards of European Regulation No. 1272 / 2008).

[0185] Comparative Example 4: Lactic acid-based disinfectant composition compared with Example 4 Composition of Comparative Example 4 (wt%): 1% lactic acid (the active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 7% 1,2-hexanediol, 1% sodium 2-ethylhexyliminodipropionate, Adjust the pH to 2.3 with 0.68% HCl (33%). An appropriate amount of water.

[0186] Classification of the compositions in Example 4: Eye calculation: H318: Only lactic acid and hydrochloric acid should be considered. 1 / 3 + 0.22 / 25 = 0.34 < 1 → The mixture is not classified as H318.

[0187] H319: Only lactic acid, hydrochloric acid, and 1,2-hexanediol should be considered. 1 / 1 + 0.22 / 10 + 7 / 10 = 1.72 > 1 → The mixture is classified as H319.

[0188] Skin calculation: H314: Only lactic acid and hydrochloric acid should be considered. 1 / 5 + 0.22 / 25 = 0.21 < 1 → The mixture is not classified as H314.

[0189] H315: Only lactic acid and hydrochloric acid should be considered. 1 / 1 + 0.22 / 10 = 1.022 > 1 → The mixture is classified as H315.

[0190] Therefore, the product is classified as not meeting the aforementioned objective (iii) (it will not be classified according to the standards of European Regulation No. 1272 / 2008).

[0191] Comparative Example 5: Disinfectant composition compared with Example 5 Composition of Comparative Example 5 (wt%): 2% propionic acid (an active substance listed in Annex I of European Regulation (EU) No. 528 / 2012). 0% 1,2-hexanediol 8% glycerin, 5% xylitol, 1% sodium octyl sulfate, 0.8% sodium lauryl glucoside hydroxypropyl sulfonate Adjust the pH to 2.3 with 0.11% HCl (33%). An appropriate amount of water.

[0192] Disinfection effect: Phase 2, Step 1: EN 1657: 1 min, 30°C, 3 g / L bovine albumin, ineffective against Candida albicans (reduction <3.02 log, while 4 log is required).

[0193] The product does not meet the above objective (iv); it does not achieve the disinfection efficacy specified in the Biocidal Products Regulation and the Practical Guide to the Biocidal Products Regulation - Volume 2, Efficacy - Assessment and Evaluation (Part B+C).

[0194] According to Embodiment 6 and Comparative Example of the present invention: Following the same protocol as in the foregoing embodiments, two compositions based on propionic acid and 1,2-hexanediol were compared with two similar compositions in which 1,2-hexanediol was replaced by citric acid. Formulations and results are summarized in Table 1 below (% are by weight): [Table 1] Compositions containing a mixture of propionic acid and 1,2-hexanediol showed efficacy within 1 minute. Compositions without 1,2-hexanediol showed no efficacy even after 5 minutes.

[0195] Example 7: Disinfectant composition according to the invention used before milking Three compositions based on propionic acid and 1,2-hexanediol were prepared according to the same protocol as in the foregoing embodiments and tested prior to milking. The formulations and results are summarized in Table 2 below (% are by weight): [Table 2] Before milking, the three compositions 7a, 7b and 7c showed efficacy within 30 seconds.

[0196] Example 8: Disinfectant composition for surface disinfection according to the present invention Composition of Example 8 (wt%): 2% propionic acid, 0.5% 1,2-hexanediol, 1% sodium octyl sulfate, Adjust the pH to 2.3 with 0.08% HCl (33%). An appropriate amount of water.

[0197] Classification of the compositions in Example 8: Specific concentration limits for propionic acid: See Example 1.

[0198] Specific concentration limits for sodium octyl sulfate and hydrochloric acid: See Example 2.

[0199] Eye calculation: H318: Only propionic acid, sodium n-octyl sulfate, and hydrochloric acid should be considered. 2 / 25 + 1 / 20 + 0.003 / 25 = 0.13 < 1 → The mixture is not classified as H318.

[0200] H319: Propionic acid, sodium n-octyl sulfate, hydrochloric acid, and 1,2-hexanediol should be considered. 2 / 10 + 1 / 10 + 0.08 / 10 + 0.5 / 10 = 0.36 < 1 → The mixture is not classified as H319.

[0201] Skin calculation: H314: Only propionic acid and hydrochloric acid should be considered. 2 / 25 + 0.08 / 25 = 0.08 < 1 → The mixture is not classified as H314.

[0202] H315: Only propionic acid, sodium n-octyl sulfate, and hydrochloric acid should be considered. 2 / 10 + 1 / 10 + 0.08 / 10 = 0.31 < 1 → The mixture is not classified as H315.

[0203] Products are not categorized.

[0204] Disinfection effect: Phase 2, Step 2: EN 13697 (maximum limit test): 10 min, 20°C, 0.3 g / L bovine albumin, 100% effective against Candida albicans.

[0205] These results demonstrate that the composition of Example 5 is effective and does not contain any substances or nanomaterials harmful to humans and the environment. Therefore, the composition meets SMA qualification requirements.

[0206] Example 9: Evaluation of different diols Evaluate the different diols in the following basic formulation 1 (the percentages shown are by weight): [Table 3] The results are summarized in Table 4 below: [Table 4] The other two diols were compared in the following basic formulation 2 (% shown are by weight): [Table 5] The results are summarized in Table 6 below.

[0207] [Table 6]

Claims

1. A disinfectant composition, characterized in that, The disinfectant composition comprises: A) Propionic acid in an amount of 0.1% to less than 10% by weight relative to the total weight of the disinfectant composition. B) At least one diol having a linear or branched aliphatic or alicyclic chain containing 4 to 8 carbon atoms, preferably 5 to 8 carbon atoms. C) At least one surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants, glycolipid surfactants, and mixtures thereof, and D) Water, The disinfectant composition has a pH greater than 2.0 and less than 4.

87.

2. The disinfectant composition according to claim 1, characterized in that, Propionate A is advantageously present in an amount of 0.1% to 5% by weight, preferably 1% to 5% by weight, relative to the total weight of the disinfectant composition.

3. The disinfectant composition according to claim 1 or claim 2, characterized in that, Diol B) is selected from 1,2-hexanediol, 2-methyl-1,3-propanediol, 2,3-butanediol, isopentanediol, 1,6-hexanediol, 1,2-pentanediol, 1,4-cyclohexanediol and mixtures thereof, preferably from 1,2-hexanediol, 1,6-hexanediol, 2,3-butanediol and mixtures thereof, and more preferably from 1,2-hexanediol, 1,6-hexanediol and mixtures thereof.

4. The disinfectant composition according to any one of claims 1 to 3, characterized in that, Diol B) is an ortho-diol containing a linear or branched aliphatic or alicyclic chain having 4 to 6 carbon atoms, preferably 1,2-hexanediol, 2,3-butanediol and mixtures thereof, more preferably 1,2-hexanediol.

5. The disinfectant composition according to any one of claims 1 to 4, characterized in that, The amount of diol B is 0.1% to less than 10% by weight, preferably 1% to 8% by weight, relative to the total weight of the disinfectant composition.

6. The disinfectant composition according to any one of claims 1 to 5, characterized in that, Surfactant C) is selected from anionic surfactants, nonionic surfactants and mixtures thereof.

7. The disinfectant composition according to claim 6, further characterized in that, when the surfactant C) is an anionic surfactant, the anionic surfactant is selected from alkyl sulfonates, olefin sulfonates, paraffin sulfonates, glucoside sulfonates, alkyl sulfates, alkyl ether sulfates, alkyl taurines, acyl glutamates, alkyl ether carboxylic acids and their salts, and mixtures thereof, preferably selected from sodium lauryl glucoside hydroxypropyl sulfonate, sodium decyl glucoside hydroxypropyl sulfonate, and 2-ethylhexyl sulfonate. Sodium octyl sulfate, sodium lauryl sulfate, sodium lauryl ether sulfate, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium octyl glutamate, octyl ether-9 carboxylic acid, optionally mixed with butanol ether-2 carboxylic acid, lauryl ether-11 carboxylic acid, and mixtures thereof, more preferably selected from sodium octyl sulfate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium 2-ethylhexyl sulfate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium octyl glutamate, and mixtures thereof.

8. The disinfectant composition according to claim 6, characterized in that, Surfactant C) is a nonionic surfactant selected from sorbitol esters, glycerol esters, polyglycerol esters, alkyl polyglucosides, alkyl polypentosides, alkyl yl lactyl lactate, ethoxylated alcohols, ethoxylated castor oil, and mixtures thereof, preferably selected from sorbitol monolaurate, sorbitol monooleate, sorbitol sesquicaprylate, glyceryl caprylate / decanoate, polyglycerol-3 caprylate, polyglycerol-4 caprylate, and C 10 -C 16 Alkyl polyglucosides, C5 and C 10 -C 12 Pentyl xyloside, lauryl lactoyl lactate, ethoxylated C 10 Alcohols, ethoxylated castor oil and mixtures thereof, more preferably selected from sorbitan monooleate, polyglycerol-4-decanoate, C 10 -C 16 Alkyl polyglucosides, ethoxylated castor oil, and mixtures thereof.

9. The disinfectant composition according to any one of claims 1 to 8, characterized in that, The surfactant C accounts for 0.1% to less than 10% by weight, preferably 0.1% to 5% by weight, relative to the total weight of the disinfectant composition.

10. The disinfectant composition according to any one of claims 1 to 9, characterized in that, The composition further comprises a humectant E), which is preferably selected from polyols other than glycol B), hyaluronic acid and its derivatives, alginate, urea, and mixtures thereof, more preferably from polyols other than glycol B, such as those selected from glycerin, propylene glycol, sorbitol, xylitol, erythritol, mannitol, xylose, and mixtures thereof, and even more preferably from glycerin, propylene glycol, and mixtures thereof.

11. The disinfectant composition according to claim 10, characterized in that, The humectant E) accounts for 0% to 30% by weight, preferably 1% to 20% by weight, relative to the total weight of the disinfectant composition.

12. The disinfectant composition according to any one of claims 1 to 11, characterized in that, The composition further comprises at least one pH adjuster (F), the nature and amount of which are selected such that the pH of the composition is greater than 2.0 and less than 4.87, wherein the pH adjuster is selected from acids such as hydrochloric acid and sulfuric acid, or bases such as sodium hydroxide and potassium hydroxide.

13. The disinfectant composition according to claim 12, characterized in that, The pH adjuster (F) accounts for 0 to 1% by weight, preferably 0.01% to 0.5% by weight, and more preferably 0.01% to 0.25% by weight, relative to the total weight of the disinfectant composition.

14. The disinfectant composition according to any one of claims 1 to 13, characterized in that, The pH of the composition is greater than 2.1 and less than 4.0, preferably greater than 2.3 and less than 3.

5.

15. The disinfectant composition according to any one of claims 1 to 14, characterized in that, The composition also includes one or more excipients selected from dyes, opacifiers and thickeners.

16. The disinfectant composition according to any one of claims 1 to 15, characterized in that, The composition is in the form of a liquid, gel, or foam and can be applied by soaking or spraying.

17. Use of the composition according to any one of claims 1 to 16 for disinfecting the udder and teats of an animal before or after milking.

18. The composition according to any one of claims 1 to 16 is used for disinfecting surfaces, preferably for disinfecting open surfaces.

19. A method for disinfecting the udder and teats of an animal before and / or after milking, comprising the following steps: (i) Applying the composition according to any one of claims 1 to 16 to the udder and teats of an animal before and / or after milking, then (ii) Optionally, the composition is removed from the animal's breast and nipple, preferably by wiping.

20. The method for disinfecting the udder and nipples of an animal according to claim 19, wherein, Before milking the animal, the disinfectant composition in step (i) is applied to the animal's udder and nipples for 30 seconds to 3 minutes, preferably 30 seconds to 1 minute and 30 seconds.

21. The method for disinfecting the udder and nipples of an animal according to claim 19, wherein, After milking the animal, the contact time of the disinfectant composition with the animal's udder and teats in step (i) is less than 5 minutes, preferably at least 30 seconds.

22. A method for disinfecting surfaces, characterized in that, The method includes applying the composition according to any one of claims 1 to 16 to a surface to be disinfected, preferably to an open surface, followed by optionally rinsing and / or drying steps.

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