Tabletting candy capable of clearing heat, relieving cough and reducing sputum

Abstract

The invention relates to the technical field of tablet candy preparation, in particular to a tablet candy capable of clearing heat, relieving cough and reducing sputum, which is prepared from the following raw materials in parts by weight: 30 to 60 parts of hydrangea powder, 15 to 60 parts of modified sweetening agent, 5 to 12 parts of functional agent, 10 to 25 parts of maltodextrin, 0.32 to 0.61 part of magnesium stearate, 0.05 to 0.2 part of powder essence and 0.09 to 0.2 part of modified menthol. According to the invention, the modified sweetening agent ensures the sweetness of the tablet candy by virtue of the high sweetness of the stevioside, the isomaltooligosacharide improves the sweet taste and reduces the calorie, and meanwhile, the embedding treatment covers the aftertaste of the stevioside; the modified siraitia grosvenorii extract in the functional agent can enhance the effects of moistening the lung to arrest cough, the ultramicro lily powder can synergistically improve the effects of clearing heat and moistening dryness, and the modified purified platycodin assists in reducing phlegm and relieving sore-throat; the modified menthol prolongs the duration of the cool feeling, avoids strong irritation caused by direct use of menthol crystals, and enables the cool feeling to be mildly released in the oral cavity.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of tablet candy preparation, in particular to a tablet candy for clearing heat, relieving cough and reducing sputum. BACKGROUND

[0002] With the increasing attention of consumers to throat health, the demand for tablet candies for clearing heat, relieving cough and reducing sputum is gradually increasing. Tablet candies can clear lung heat and relieve dry heat of the throat, and improve problems such as swollen and painful throat, dry itching, hoarse voice and the like caused by lung heat or heatiness.

[0003] In the prior art, traditional sweeteners such as sucrose are mainly used alone, which has high heat and is not suitable for diabetics or sugar control groups, and there are obvious problems of obvious after-bitterness and strong hygroscopicity, which can cause the tablet candy to be damp, sticky and deteriorated. Traditional functional raw materials are simply pulverized or crude extracts, and the low dissolution rate of effective components leads to poor synergy between components and poor overall heat-clearing and cough-relieving effect.

[0004] Based on this, the present application provides a tablet candy for clearing heat, relieving cough and reducing sputum. SUMMARY

[0005] The present application aims to provide a tablet candy for clearing heat, relieving cough and reducing sputum. The tablet candy prepared by the present application has high dissolution rate of effective components and prolonged cough latency, and low hygroscopicity.

[0006] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a tablet candy for clearing heat, relieving cough and reducing sputum, comprising the following raw materials by weight: 30-60 parts of bretschneider apricot kernel powder, 15-60 parts of modified sweetener, 5-12 parts of functional agent, 10-25 parts of malt dextrin, 0.32-0.61 parts of magnesium stearate, 0.05-0.2 parts of powder flavor, and 0.09-0.2 parts of modified menthol.

[0007] The modified sweetener is a complex modified product of stevioside and isomalto-oligosaccharide.

[0008] The functional agent is composed of 3-5 parts of modified monk fruit extract, 1-3 parts of super-fine lily powder and 1-4 parts of modified purified platycodon saponin.

[0009] Preferably, the preparation steps of the modified sweetener are as follows: stevioside and isomalto-oligosaccharide are mixed in proportion, stirred uniformly to obtain a complex sweetener; then the complex sweetener is mixed with an embedding liquid at a solid-liquid ratio of 1:(4-6), and stirred at 300-400 r / min at 60-65 DEG C for 40-50 min for embedding reaction; then the reaction liquid is frozen at (-20)-(-18) DEG C for 2-3 h, and then dried by a freeze dryer for 8-10 h, and then pulverized through a 80-mesh stainless steel sieve to obtain the modified sweetener.

[0010] Preferably, the preparation step of the embedding solution is: selecting β-cyclodextrin as the embedding agent, dissolving it in deionized water with a temperature of 60-70℃, continuously stirring during the dissolving process to ensure that the β-cyclodextrin is fully dissolved, finally preparing a solution with a mass concentration of 20%-25%, and then adjusting the pH value of the solution to 6.0-6.5 by sodium hydroxide solution to obtain the embedding solution.

[0011] Preferably, the mass ratio of steviol glycosides to isomaltooligosaccharides in the modified sweetener is 1:(5-8).

[0012] Preferably, the preparation step of the modified Lo Han Guo is: dissolving the Lo Han Guo crude extract in deionized water to prepare a solution with a mass concentration of 10%-15%, adjusting the pH to 5.0-5.5, adding 0.5%-1% of the mass of the crude extract of α-amylase, enzymatic hydrolysis in a constant temperature water bath at 50-55℃ for 30-40min, heating to 95-100℃ to inactivate the enzyme for 10min, cooling and vacuum concentration to extract, and then spray drying to obtain the modified Lo Han Guo extract.

[0013] Preferably, the step of modifying and purifying the jujube saponin is: crushing the jujube root, refluxing extraction with 70% ethanol to obtain a crude saponin solution, loading the crude saponin solution onto an AB-8 type macroporous resin column with a height-diameter ratio of 1:8, first eluting the impurities with water, then eluting with a 70-75% ethanol solution, collecting the eluate, vacuum concentrating to remove the alcohol taste, freeze-drying and then crushing to pass through a 100 mesh sieve to obtain the modified and purified jujube saponin.

[0014] Preferably, the preparation step of the functional agent is: washing and drying fresh lily bulbs, first crushing them to 80 mesh with a universal crusher, then crushing them to a particle size of 50-80μm with a super micro crusher, and then placing them in a 80-85℃ air oven for low-temperature baking for 30min to inactivate the oxidase, to obtain super micro lily powder; then according to the specified weight, the modified Lo Han Guo extract, the super micro lily powder and the modified jujube saponin are put into a three-dimensional mixer together, and mixed at a speed of 25-30r / min for 15-20min to obtain the functional agent.

[0015] Preferably, the preparation step of the modified menthol is: crushing the menthol to 100 mesh, adding the menthol to the embedding agent solution, and the mass ratio of menthol to embedding agent is 1:(8-10), stirring at a speed of 250-300r / min for 30min to form a uniform emulsion; the emulsion is sent to a spray dryer, the inlet air temperature is controlled at 170-180℃, the outlet air temperature is controlled at 75-80℃, and the feeding speed is controlled at 15-20mL / min, and the powder is collected after drying to obtain menthol microcapsules, i.e. modified menthol.

[0016] Preferably, the preparation step of the embedding agent solution is: selecting gum arabic and malt dextrin mixed as embedding agent at a mass ratio of 1:2, dissolving in deionized water at a temperature of 50-55 DEG C, continuously stirring during the dissolving process to ensure complete dissolution, and finally preparing an embedding agent solution with a mass concentration of 15%-20%.

[0017] The preparation of the heat-clearing, cough-relieving and phlegm-eliminating tabletted candy specifically comprises the following steps:

[0018] S1: the powder of octopus fruit, functional agent, malt dextrin and modified sweetener are put into a three-dimensional mixer at a weight ratio, mixed at a speed of 25-30 r / min for 15-20 min, then powder essence and modified menthol are added and mixed for another 5-8 min to obtain uniformly mixed powder;

[0019] S2: hydroxypropyl methyl cellulose aqueous solution is slowly added to the mixed powder as a binder, and stirred at a speed of 120-150 r / min until a soft material that can be held into a ball and scattered by a light touch is formed; the soft material is placed in a swinging granulator and sieved through a 16-mesh nylon screen to obtain wet granules;

[0020] S3: the wet granules are sent into a fluidized bed dryer, the inlet air temperature is controlled at 65-70 DEG C, and the air speed is controlled at 1.8-2.0 m / s, and the granules are dried until the moisture content is 3%-5% to obtain dry granules;

[0021] S4: the dry granules are placed in a swinging granulator and sieved through a 14-mesh nylon screen to remove lumpy granules and fine powder;

[0022] S5: magnesium stearate is added to the dry granules after sieving, and the total mixture is obtained by mixing in a three-dimensional mixer at a speed of 15-20 r / min for 10-15 min;

[0023] S6: the total mixture is put into a rotary tablet press, and the parameters are adjusted as follows: tablet weight 0.5-1.0 g / tablet, tablet thickness 2-4 mm, and tabletting pressure 30-40 kN, and then circular or oval tablets are prepared;

[0024] S7: the pressed tablets are sent into an aluminum plastic blister packaging machine, and the tablets are blister packaged by using PVC hard sheets with a thickness of 0.2-0.3 mm and aluminum foils with a thickness of 0.02-0.03 mm, 12 tablets or 24 tablets per plate, and the heat-clearing, cough-relieving and phlegm-eliminating tabletted candy is obtained after packaging.

[0025] Compared with the prior art, the heat-clearing, cough-relieving and phlegm-eliminating tabletted candy has the following beneficial effects:

[0026] 1. The sweetener is modified by compounding steviol glycosides with isomalto-oligosaccharides and embedding with beta-cyclodextrin. The advantages of high sweetness and low heat of steviol glycosides are utilized (suitable for sugar control groups), and the softness of the sweetness and the masking of the aftertaste of steviol glycosides are improved by isomalto-oligosaccharides. The embedding treatment also improves the moisture resistance of the sweetener, avoids product deterioration due to dampness, prolongs the shelf life, and improves the tabletting formability.

[0027] 2. The functional agent is modified by enzymatic treatment of momordica grosvenori extract, which improves the dissolution rate of effective components such as mogroside; the super-fine lily powder is treated by super-fine grinding + low-temperature baking, which improves the powder dispersibility and effective component dissolution, and inactivates the oxidase to avoid flavor deterioration; the purified platycodon grandiflorum saponin is modified by macroporous resin purification, which improves the purity and activity of the saponin; the synergistic effect of the three improves the comprehensive efficacy of clearing heat, relieving cough and reducing phlegm, and solves the problems of low effective component dissolution rate, weak synergistic effect and raw material deterioration of traditional functional components.

[0028] 3. The menthol is microencapsulated by embedding with an embedding agent of gum arabic and malt dextrin, the microcapsule structure formed can reduce the volatilization loss of menthol, making the cooling sensation more lasting; the distribution of the microencapsulated menthol is more uniform, avoiding sticking and collision during tabletting, and improving the production process stability; at the same time, the menthol is slowly released in the oral cavity, reducing the irritability of menthol and improving the palatability of the product, solving the problems of easy volatilization, poor stability and poor palatability of traditional menthol. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0030] It should be noted that the raw materials used in the following experiments are all commercially available.

[0031] Example 1: A tablet candy for clearing heat, relieving cough and reducing phlegm, comprising the following raw materials by weight: 30 parts of eight immortals fruit powder, 15 parts of modified sweetener, 5 parts of functional agent, 10 parts of malt dextrin, 0.32 parts of magnesium stearate, 0.05 parts of powder flavor, and 0.09 parts of modified menthol.

[0032] The modified sweetener is a compound modification of steviol glycosides and isomalto-oligosaccharides.

[0033] The functional agent is composed of 3 parts of modified momordica grosvenori extract, 1 part of super-fine lily powder and 1 part of modified purified platycodon grandiflorum saponin.

[0034] The preparation steps of the modified sweetener are: mixing steviol glycosides and isomaltooligosaccharides in proportion, stirring uniformly to obtain a compound sweetener; then mixing the compound sweetener with an embedding liquid in a solid-liquid ratio of 1:4, stirring at 300 r / min at 60℃ for 40 min to perform embedding reaction; then freezing the reaction liquid at-20℃ for 2 h, drying by a freeze dryer for 8 h, and crushing through an 80-mesh stainless steel sieve to obtain the modified sweetener.

[0035] The preparation steps of the embedding liquid are: selecting β-cyclodextrin as an embedding agent, dissolving it in deionized water at a temperature of 60℃, continuously stirring during the dissolving process to ensure that the β-cyclodextrin is fully dissolved, finally preparing a solution with a mass concentration of 20%, and then adjusting the pH value of the solution to 6.0 by a sodium hydroxide solution to obtain the embedding liquid.

[0036] The mass ratio of steviol glycosides to isomaltooligosaccharides in the modified sweetener is 1:5.

[0037] The preparation steps of the modified monk fruit are: dissolving the crude extract of monk fruit in deionized water to prepare a solution with a mass concentration of 10%, adjusting the pH to 5.0, adding α-amylase with a mass of 0.5% of the crude extract, enzymolysis at 50℃ for 30 min, heating to 95℃ to inactivate the enzyme for 10 min, cooling, and reducing pressure to concentrate into an extract, and then spray drying to obtain the modified monk fruit extract.

[0038] The steps for preparing the modified and purified saponins of the balloonflower root are: crushing the balloonflower root, reflux extracting with 70% ethanol to obtain a crude saponin liquid, loading the crude saponin liquid onto an AB-8 type macroporous resin column with a height-diameter ratio of 1:8, first washing off impurities with water, then eluting with a 70% ethanol solution, collecting the eluate, reducing pressure to concentrate to no alcohol taste, freeze-drying, and crushing through a 100-mesh sieve to obtain the modified and purified saponins of the balloonflower root.

[0039] The preparation steps of the functional agent are: washing and drying fresh lily bulbs, initially crushing them to 80 mesh by a universal crusher, then crushing them to a particle size of 50 μm by a super micro crusher, then placing them in a 80℃ air oven for low-temperature baking for 30 min to inactivate oxidase, to obtain super micro lily powder; then putting the modified monk fruit extract, the super micro lily powder, and the modified balloonflower root saponins into a three-dimensional mixer according to the specified weight parts, and mixing at a speed of 25 r / min for 15 min to obtain the functional agent.

[0040] The preparation steps of the modified menthol are: crushing menthol to 100 mesh, adding the menthol into the embedding agent solution, and stirring at a speed of 250 r / min for 30 min to form a uniform emulsion, with the mass ratio of menthol to embedding agent being 1:8; then feeding the emulsion into a spray dryer, controlling the inlet air temperature to be 170℃, the outlet air temperature to be 75℃, and the feeding speed to be 15 mL / min, collecting the powder after drying to obtain menthol microcapsules, i.e. the modified menthol.

[0041] The preparation steps of the embedding agent solution are: selecting gum arabic and malt dextrin as the embedding agent, mixing them according to a mass ratio of 1:2, dissolving them in deionized water at a temperature of 50 DEG C, continuously stirring during the dissolving process to ensure complete dissolution, and finally preparing an embedding agent solution with a mass concentration of 15%.

[0042] The preparation of the tabletting candy for clearing heat, relieving cough and reducing sputum specifically includes the following steps:

[0043] S1: The powder of eight wonder fruits, functional agents, malt dextrin and modified sweeteners are put into a three-dimensional mixer at a weight ratio, mixed at a speed of 25 r / min for 15 min, then powder essence and modified menthol are added and mixed for another 5 min to obtain uniformly mixed powder;

[0044] S2: Hydroxypropyl methyl cellulose aqueous solution is slowly added to the mixed powder as a binder, and stirred at a speed of 120 r / min until the soft material can be held into a ball and scattered by a light touch; the soft material is placed in a swing granulator and sieved through a 16-mesh nylon screen to obtain wet granules;

[0045] S3: The wet granules are sent to a fluidized bed dryer, the inlet air temperature is controlled at 65 DEG C and the air speed is 1.8 m / s, and the granules are dried until the moisture content is 3%; dry granules are obtained;

[0046] S4: The dry granules are placed in a swing granulator and sieved through a 14-mesh nylon screen to remove lumpy granules and fine powder;

[0047] S5: Magnesium stearate is added to the dry granules after sieving, and a three-dimensional mixer is used to mix at a speed of 15 r / min for 10 min to obtain total mixture;

[0048] S6: The total mixture is put into a rotary tablet press, and the parameters are adjusted as follows: tablet weight 0.5 g / tablet, tablet thickness 2 mm, and tabletting pressure 30 kN, and then circular or oval tablets are pressed;

[0049] S7: The pressed tablets are sent to an aluminum plastic blister packaging machine, and PVC hard sheets with a thickness of 0.2-0.3 mm and aluminum foil with a thickness of 0.02 mm are used for blister packaging, 12 tablets or 24 tablets per plate, and the tabletting candy for clearing heat, relieving cough and reducing sputum is obtained after packaging.

[0050] Example 2: A tabletting candy for clearing heat, relieving cough and reducing sputum, which comprises the following weight parts of raw materials: 45 parts of eight wonder fruit powder, 37 parts of modified sweetener, 8 parts of functional agent, 17 parts of malt dextrin, 0.46 parts of magnesium stearate, 0.12 parts of powder essence and 0.15 parts of modified menthol;

[0051] The modified sweetener is a complex modified product of stevioside and low oligomaltose;

[0052] The functional agent is composed of 4 parts of modified monk fruit extract, 2 parts of superfine lily powder and 2 parts of modified purified lycianthes saponin.

[0053] The preparation steps of the modified sweetener are as follows: mixing steviol glycosides and isomaltooligosaccharides in proportion, stirring uniformly to obtain a compound sweetener; mixing the compound sweetener with an embedding liquid in a solid-liquid ratio of 1:5, stirring at 350 r / min at 62℃ for 45 min to perform embedding reaction; then freezing the reaction liquid at -19℃ for 2.5 h, drying by a freeze dryer for 9 h, and crushing through an 80-mesh stainless steel sieve to obtain the modified sweetener.

[0054] The preparation steps of the embedding liquid are as follows: selecting β-cyclodextrin as an embedding agent, dissolving it in deionized water with a temperature of 65℃, continuously stirring during the dissolving process to ensure that the β-cyclodextrin is fully dissolved, finally preparing a solution with a mass concentration of 22.5%, and then adjusting the pH value of the solution to 6.2 by a sodium hydroxide solution to obtain the embedding liquid.

[0055] The mass ratio of steviol glycosides to isomaltooligosaccharides in the modified sweetener is 1:6.5.

[0056] The preparation steps of the modified monk fruit are as follows: dissolving the crude monk fruit extract in deionized water to prepare a solution with a mass concentration of 12.5%, adjusting the pH to 5.2, adding 0.7% of the mass of the crude extract of α-amylase, enzyme hydrolysis in a 52℃ constant temperature water bath for 35 min, increasing the temperature to 98℃ to inactivate the enzyme for 10 min, cooling, and reducing pressure to concentrate into an extract, and then spray drying to obtain the modified monk fruit extract.

[0057] The steps of the modified purified lycianthes saponin are as follows: crushing the root of lycianthes saponin, reflux extracting with 70% ethanol to obtain a crude saponin liquid, loading the crude saponin liquid onto an AB-8 type macroporous resin column with a diameter-height ratio of 1:8, first eluting impurities with water, then eluting with a 72% ethanol solution, collecting the eluate, reducing pressure to concentrate to no alcohol taste, freeze-drying, and crushing through a 100-mesh sieve to obtain the modified purified lycianthes saponin.

[0058] The preparation steps of the functional agent are as follows: washing and drying fresh lily bulbs, initially crushing them to 80 mesh by a universal crusher, then crushing them to a particle size of 65μm by a superfine crusher, then placing them in a 82℃ air oven for low-temperature baking for 30 min to inactivate oxidase, to obtain superfine lily powder; then putting the modified monk fruit extract, superfine lily powder and modified lycianthes saponin into a three-dimensional mixer according to the specified weight parts, mixing at a speed of 27 r / min for 17 min to obtain the functional agent.

[0059] The preparation steps of the modified menthol are as follows: the menthol is crushed to 100 meshes, the menthol is added into the embedding agent solution, the mass ratio of the menthol and the embedding agent is 1:9, the uniform emulsion is formed by stirring at a speed of 275 r / min for 30 min, the emulsion is sent into the spray dryer, the inlet air temperature is controlled at 175℃, the outlet air temperature is controlled at 77℃, the feeding speed is controlled at 17 mL / min, the powder is collected after drying, and the menthol microcapsule, i.e. the modified menthol, is prepared.

[0060] The preparation steps of the embedding agent solution are as follows: the gum arabic and the malt dextrin are mixed according to the mass ratio of 1:2 as the embedding agent, the embedding agent is dissolved in the deionized water with a temperature of 52℃, the embedding agent is continuously stirred during the dissolving process to ensure complete dissolution, and finally the embedding agent solution with a mass concentration of 17% is prepared.

[0061] The preparation of the tabletting candy for clearing heat, relieving cough and reducing sputum specifically includes the following steps:

[0062] S1: the powder of the eight immortals fruit, the functional agent, the malt dextrin and the modified sweetening agent are put into a three-dimensional mixer according to the weight parts, mixed at a speed of 27 r / min for 17 min, the powder essence and the modified menthol are further added and mixed for 6.5 min, and the uniformly mixed powder material is obtained;

[0063] S2: the hydroxypropyl methyl cellulose aqueous solution is slowly added into the mixed powder material as the binder, the mixed powder material is stirred at a speed of 135 r / min during the adding process, and the soft material which can be held into a ball and scattered by a light touch is formed; the soft material is placed in a swing granulator, and the wet granules are prepared by passing through a 16-mesh nylon screen;

[0064] S3: the wet granules are sent into a boiling dryer, the inlet air temperature is controlled at 67℃, the air speed is controlled at 1.9 m / s, the granules are dried until the water content is 4%, and the dry granules are obtained;

[0065] S4: the dry granules are placed in the swing granulator, the dry granules are granulated by passing through a 14-mesh nylon screen, and the blocky granules and fine powder are removed;

[0066] S5: the magnesium stearate is added into the dry granules after granulation, and the total mixed material is obtained by putting the dry granules into a three-dimensional mixer and mixing at a speed of 17 r / min for 12 min;

[0067] S6: the total mixed material is put into a rotary tablet press, and the parameters are adjusted as follows: the tablet weight is 0.7 g / tablet, the tablet thickness is 3 mm, and the tabletting pressure is 35 kN, and the round or oval tablets are prepared by compression;

[0068] S7: the compressed tablets are sent into an aluminum plastic blister packaging machine, the tablets are blister packaged by using the PVC hard sheet with a thickness of 0.25 mm and the aluminum foil with a thickness of 0.025 mm, and each plate has 12 tablets or 24 tablets, and the tabletting candy for clearing heat, relieving cough and reducing sputum is obtained after packaging.

[0069] Embodiment 3: a heat-clearing and cough-relieving and phlegm-dissolving tablet candy, comprising the following raw materials in parts by weight: 60 parts of Momordica Grosvenorii powder, 60 parts of modified sweetener, 12 parts of functional agent, 25 parts of malt dextrin, 0.61 parts of magnesium stearate, 0.2 parts of powder flavor, and 0.2 parts of modified menthol.

[0070] The modified sweetener is a compound modification of steviol glycoside and isomalto-oligosaccharide.

[0071] The functional agent is composed of 5 parts of modified Momordica Grosvenorii extract, 3 parts of super-fine lily powder, and 4 parts of modified purified Platycodon grandiflorum saponin.

[0072] The preparation steps of the modified sweetener are as follows: steviol glycoside and isomalto-oligosaccharide are mixed in proportion, stirred uniformly to obtain a compound sweetener; then the compound sweetener is mixed with an embedding liquid at a solid-liquid ratio of 1:6, and an embedding reaction is carried out at 65℃ and 400r / min for 50min; then the reaction liquid is frozen at-18℃ for 3h, dried by a freeze dryer for 10h, and then crushed through an 80-mesh stainless steel sieve to obtain the modified sweetener.

[0073] The preparation steps of the embedding liquid are as follows: β-cyclodextrin is selected as the embedding agent, dissolved in deionized water at a temperature of 70℃, and continuously stirred during the dissolution process to ensure that the β-cyclodextrin is fully dissolved, and finally a solution with a mass concentration of 25% is prepared; then the pH value of the solution is adjusted to 6.5 by a sodium hydroxide solution to obtain the embedding liquid.

[0074] The mass ratio of steviol glycoside to isomalto-oligosaccharide in the modified sweetener is 1:8.

[0075] The preparation steps of the modified Momordica Grosvenorii are as follows: the crude extract of Momordica Grosvenorii is dissolved in deionized water to prepare a solution with a mass concentration of 15%, the pH is adjusted to 5.5, and 1% of the mass of the crude extract of α-amylase is added, and the enzyme is hydrolyzed in a constant-temperature water bath at 55℃ for 40min, and then the temperature is raised to 100℃ to inactivate the enzyme for 10min; after cooling, the extract is concentrated under reduced pressure, and then spray-dried to obtain the modified Momordica Grosvenorii extract.

[0076] The steps for preparing the modified purified Platycodon grandiflorum saponin are as follows: the roots of Platycodon grandiflorum are crushed and extracted with 70% ethanol by reflux to obtain a crude saponin solution, the crude saponin solution is loaded onto an AB-8 macroporous resin column with a diameter-height ratio of 1:8, impurities are first eluted with water, and then the eluate is collected and concentrated under reduced pressure until there is no alcohol smell, and then freeze-dried and crushed through a 100-mesh sieve to obtain the modified purified Platycodon grandiflorum saponin.

[0077] The preparation steps of the functional agent are as follows: after the fresh lily bulb is cleaned and dried, it is firstly crushed to 80 meshes by a universal crusher, and then crushed to a particle size of 80 μm by a super micro crusher, and then placed in a 85 ℃ air oven for low-temperature baking for 30 min to inactivate the oxidase, thereby preparing the super micro lily powder; then the modified momordica grosvenori extract, the super micro lily powder and the modified luffa saponin are put into a three-dimensional mixer according to the specified weight parts, and mixed at a speed of 30 r / min for 20 min, thereby preparing the functional agent.

[0078] The preparation steps of the modified menthol are as follows: the menthol is crushed to 100 meshes, the menthol is added into the embedding agent solution, and the mass ratio of the menthol and the embedding agent is 1:10, the solution is stirred at a speed of 300 r / min for 30 min to form a uniform emulsion; the emulsion is sent into a spray dryer, the inlet air temperature is controlled at 180 ℃, the outlet air temperature is controlled at 80 ℃, and the feeding speed is controlled at 20 mL / min, and the powder is collected after drying, thereby preparing the menthol microcapsule, i.e. the modified menthol.

[0079] The preparation steps of the embedding agent solution are as follows: the gum arabic and the malt dextrin are mixed according to a mass ratio of 1:2 as the embedding agent, and the embedding agent is dissolved in deionized water with a temperature of 55 ℃, and the embedding agent is continuously stirred during the dissolving process to ensure complete dissolution, and finally the embedding agent solution with a mass concentration of 20% is prepared.

[0080] The preparation of the tabletted candy for clearing heat, relieving cough and reducing sputum specifically includes the following steps:

[0081] S1: the eight immortals fruit powder, the functional agent, the malt dextrin, the modified sweetener are put into a three-dimensional mixer according to the weight parts, mixed at a speed of 30 r / min for 20 min, and then the powder flavor and the modified menthol are added and continuously mixed for 8 min, thereby obtaining uniformly mixed powder;

[0082] S2: the hydroxypropyl methyl cellulose aqueous solution is slowly added into the mixed powder as a binder, and stirred at a speed of 150 r / min during the adding process, until a soft material which can be held into a ball and scattered by a light touch is formed; the soft material is placed in a swinging granulator, and wet granules are prepared by passing through a 16-mesh nylon screen;

[0083] S3: the wet granules are sent into a fluidized bed dryer, the inlet air temperature is controlled at 70 ℃, and the air speed is controlled at 2.0 m / s, and the granules are dried until the water content is 5%, thereby obtaining dry granules;

[0084] S4: the dry granules are placed in a swinging granulator, and the granules are sized by passing through a 14-mesh nylon screen, and the blocky granules and fine powder are removed;

[0085] S5: the magnesium stearate is added into the sized dry granules, and put into a three-dimensional mixer and mixed at a speed of 20 r / min for 15 min, thereby obtaining the total mixture;

[0086] S6: The total mixture was put into a rotary tablet press, and the parameters were adjusted as follows: tablet weight 1.0 g / tablet, tablet thickness 4 mm, tabletting pressure 40 kN, and the tablets were compressed into round or oval tablets;

[0087] S7: The compressed tablets were put into an aluminum plastic blister packaging machine, and the tablets were blister packaged with PVC hard sheets with a thickness of 0.3 mm and aluminum foil with a thickness of 0.03 mm, 12 tablets or 24 tablets per plate, and after packaging, the heat-clearing and cough-relieving and phlegm-eliminating tablet candies were obtained.

[0088] Comparative Example 1, the difference between the comparative example and Examples 1-3 is that the sweetener in the comparative example is not modified.

[0089] Comparative Example 2, the difference between the comparative example and Examples 1-3 is that the functional agent in the comparative example is not modified.

[0090] Comparative Example 3, the difference between the comparative example and Examples 1-3 is that the menthol in the comparative example is not modified.

[0091] Performance test: the prepared Examples 1, 2, 3, Comparative Examples 1, 2, and 3 were subjected to performance tests:

[0092] Effective ingredient dissolution rate test: the tablet candies were finely ground, and about 10 mg of powder containing total mogroside V and lirin D was weighed and placed in a dissolution cup of a dissolution instrument, 900 mL of pH 6.8 phosphate buffer was added as the dissolution medium, the temperature was set at 37±0.5℃, and the stirring paddle speed was 50 r / min; 5 mL of sample was taken every 15 min (while the same amount of same-temperature dissolution medium was supplemented), filtered through a 0.45 μm microporous filter, and the filtrate was taken as the test solution; high performance liquid chromatography was used for determination, the chromatographic column was a C18 column, the mobile phase was acetonitrile-0.1% phosphoric acid aqueous solution, the detection wavelength was 203 nm for mogroside V and 210 nm for lirin D, the flow rate was 1.0 mL / min, and the column temperature was 30℃; the percentage of the cumulative dissolution amount at 60 min to the total content of the effective ingredients in the sample was taken as the effective ingredient dissolution rate, and the test was based on Chinese Pharmacopoeia 0931;

[0093] In vitro cough-relieving effect (cough latency extension rate) test: healthy guinea pigs were given intragastrically and injected with normal saline, respectively, 1 h later, the guinea pigs were placed in a glass cover, and 17.5% citric acid aerosol was sprayed into the respiratory mucosa for 5-10 s to stimulate cough, the cough latency of the guinea pigs was recorded, and the cough latency extension rate was calculated, and the reference was based on the guinea pig citric acid-induced cough model;

[0094] Moisture absorption rate test: take the compressed candy sample, first place in a temperature of 25℃, relative humidity of 40%±5% of the dryer, dry to constant weight record m0; then take 3 parallel samples, respectively, into the constant weight of the weighing bottle; the weighing bottle is placed in a constant temperature and humidity chamber, set temperature 25℃±1℃, relative humidity 75%±2%, avoid light and place for 7 days; during the same time every day, take out the weighing bottle, quickly cover the bottle cap and weigh with a millionth analytical balance, record daily mass mt; after 7 days, record the final mass m7, obtain the moisture absorption rate, test basis: <Chinese Pharmacopoeia> general 9101.

[0095] The obtained test data are recorded in Table 1 below:

[0096]

[0097] By comparison and analysis of the related data in Table 1, it can be seen that the compressed candy prepared by the compressed candy for clearing heat, relieving cough and reducing sputum has higher dissolution rate of effective components and longer extension rate of cough latency, and lower moisture absorption rate. Therefore, the compressed candy for clearing heat, relieving cough and reducing sputum provided by the application has a broader market prospect and is more suitable for promotion.

[0098] In the description of the present specification, the description of the terms "one embodiment", "example", "specific example" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are contained in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0099] The preferred embodiments of the application disclosed above are only used to help explain the application. The preferred embodiments do not describe all the details and limit the application to the specific embodiments described. Obviously, many modifications and changes can be made according to the content of the present specification. The present specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the application, so that those skilled in the art can well understand and utilize the application. The application is limited only by the claims and their entire scope and equivalents.

Claims

1. A compressed candy for clearing heat, relieving cough, and resolving phlegm, characterized in that: The preparation method comprises the following steps: mixing 30-60 parts of acai berry powder, 15-60 parts of a modified sweetener, 5-12 parts of a functional agent, 10-25 parts of malt dextrin, 0.32-0.61 parts of magnesium stearate, 0.05-0.2 parts of powder essence and 0.09-0.2 parts of modified menthol to prepare a mixture; and then mixing the mixture with 0.1-0.3 parts of acai berry powder to prepare a final product. The modified sweetener is a compound modification of stevioside and isomaltooligosaccharide. The functional agent is composed of 3-5 parts of modified monk fruit extract, 1-3 parts of superfine lily powder and 1-4 parts of modified purified platycodon saponin.

2. The heat-clearing, cough-relieving and phlegm-dissolving tablet candy according to claim 1, characterized in that, The preparation steps of the modified sweetener are as follows: mixing stevioside and isomaltooligosaccharide in a certain proportion, stirring uniformly to obtain a compound sweetener; mixing the compound sweetener with an embedding liquid in a solid-liquid ratio of 1:(4-6), stirring at 300-400 r / min at 60-65 DEG C for 40-50 min to perform embedding reaction; then freezing the reaction liquid at (-20)-(-18) DEG C for 2-3 h, drying by a freeze dryer for 8-10 h, and then crushing through a 80-mesh stainless steel sieve to obtain the modified sweetener.

3. The heat-clearing, cough-relieving and phlegm-dissolving tablet candy according to claim 2, characterized in that, The preparation steps of the embedding liquid are as follows: selecting β-cyclodextrin as an embedding agent, dissolving the β-cyclodextrin in deionized water with a temperature of 60-70 DEG C, continuously stirring during the dissolving process to ensure that the β-cyclodextrin is fully dissolved, finally preparing a solution with a mass concentration of 20%-25%, and then adjusting the pH value of the solution to 6.0-6.5 by a sodium hydroxide solution to obtain the embedding liquid.

4. The heat-clearing, cough-relieving and phlegm-dissolving tablet candy according to claim 1, characterized in that, The mass ratio of stevioside to isomaltooligosaccharide in the modified sweetener is 1:(5-8).

5. The heat-clearing, cough-relieving and phlegm-dissolving tabletted candy according to claim 1, characterized in that, The preparation steps of the modified monk fruit are as follows: dissolving monk fruit crude extract in deionized water to prepare a solution with a mass concentration of 10%-15%, adjusting the pH value to 5.0-5.5, adding 0.5%-1% of α-amylase based on the mass of the crude extract, performing enzyme hydrolysis in a constant-temperature water bath at 50-55 DEG C for 30-40 min, increasing the temperature to 95-100 DEG C to inactivate the enzyme for 10 min, cooling, and then reducing pressure to concentrate into an extract, and then performing spray drying to obtain the modified monk fruit extract.

6. The heat-clearing, cough-relieving and phlegm-dissolving tabletted candy according to claim 1, characterized in that, The steps of preparing the modified purified platycodon saponin are as follows: crushing platycodon root, reflux extracting the platycodon root with 70% ethanol to obtain a crude saponin liquid, loading the crude saponin liquid onto an AB-8 macroporous resin column with a diameter-height ratio of 1:8, first washing off impurities with water, then eluting with a 70-75% ethanol solution, collecting the eluent, reducing pressure to concentrate the eluent to be alcohol-free, freeze-drying, and then crushing through a 100-mesh sieve to obtain the modified purified platycodon saponin.

7. The heat-clearing, cough-relieving and phlegm-dissolving tabletted candy according to claim 1, characterized in that, The preparation steps of the functional agent are as follows: cleaning and drying fresh lily bulbs, initially crushing the lily bulbs to 80 mesh by a universal crusher, then crushing the lily bulbs to a particle size of 50-80 μm by a supermicro pulverizer, then placing the lily bulbs in a 80-85 DEG C air oven for low-temperature baking for 30 min to inactivate oxidase, and then obtaining superfine lily powder; and then putting the modified monk fruit extract, the superfine lily powder and the modified platycodon saponin into a three-dimensional mixer according to the specified weight parts, mixing at a rotating speed of 25-30 r / min for 15-20 min to obtain the functional agent.

8. The heat-clearing, cough-relieving and phlegm-dissolving tabletted candy according to claim 1, characterized in that, The preparation steps of the modified menthol are as follows: the menthol is crushed to 100 meshes, the menthol is added into an embedding agent solution, the mass ratio of the menthol and the embedding agent is 1: (8-10), the uniform emulsion is formed by stirring at a rotating speed of 250-300 r / min for 30 min, the emulsion is sent into a spray dryer, the inlet air temperature is controlled at 170-180 ℃, the outlet air temperature is controlled at 75-80 ℃, the feeding speed is controlled at 15-20 mL / min, the powder is collected after drying, and the menthol microcapsule, i.e., the modified menthol, is prepared.

9. The heat-clearing, cough-relieving and phlegm-dissolving tabletted candy according to claim 8, characterized by, The preparation steps of the embedding agent solution are as follows: the gum arabic and the malt dextrin are mixed according to a mass ratio of 1:2 as the embedding agent, the embedding agent is dissolved in deionized water with a temperature of 50-55 ℃, the embedding agent is continuously stirred during the dissolving process to ensure complete dissolution, and finally the embedding agent solution with a mass concentration of 15%-20% is prepared.

10. The heat-clearing, cough-relieving and phlegm-dissolving tabletted candy according to claim 1, characterized in that, The preparation of the heat-clearing, cough-relieving and phlegm-resolving tablet candy specifically includes the following steps: S1: the powder of the eight-immortals fruit, the functional agent, the malt dextrin, and the modified sweetening agent are put into a three-dimensional mixer according to weight parts, mixed at a rotating speed of 25-30 r / min for 15-20 min, the powder essence and the modified menthol are further added and mixed for 5-8 min, and the uniformly mixed powder material is obtained; S2: the hydroxypropyl methyl cellulose aqueous solution is slowly added into the mixed powder material as a binder, and stirred at a rotating speed of 120-150 r / min until the soft material is formed, which can be held into a ball and scattered by a light touch; the soft material is placed in a swing granulator, and wet granules are prepared by passing through a 16-mesh nylon screen; S3: the wet granules are sent into a boiling dryer, the inlet air temperature is controlled at 65-70 ℃, and the air speed is controlled at 1.8-2.0 m / s, and the granules are dried until the water content is 3%-5%, and the dry granules are obtained; S4: the dry granules are placed in a swing granulator, and the granules are sized by passing through a 14-mesh nylon screen, and the blocky granules and fine powder are removed; S5: the magnesium stearate is added into the sized dry granules, and put into a three-dimensional mixer to mix at a rotating speed of 15-20 r / min for 10-15 min, and the total mixture is obtained; S6: the total mixture is put into a rotary tablet press, and the parameters are adjusted as follows: the tablet weight is 0.5-1.0 g / tablet, the tablet thickness is 2-4 mm, and the tabletting pressure is 30-40 kN, and the round or oval tablets are prepared; S7: the pressed tablets are sent into an aluminum plastic blister packaging machine, the PVC hard sheet with a thickness of 0.2-0.3 mm and the aluminum foil with a thickness of 0.02-0.03 mm are used for blister packaging, 12 tablets or 24 tablets are packaged in each plate, and the heat-clearing, cough-relieving and phlegm-resolving tablet candy is obtained after packaging.

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