Traditional Chinese medicine fumigation bag for relieving eye fatigue and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine fumigation bag for relieving eye fatigue and a preparation method and application thereof, and belongs to the technical field of eye medicine. The traditional Chinese medicine fumigation bag for relieving eye fatigue is prepared from the following components in parts by weight: 10 to 30 parts of flos chrysanthemi indici, 10 to 30 parts of frosted folium mori, 10 to 30 parts of semen cassiae, 10 to 30 parts of herba gynostemmatis pentaphylli, 5 to 20 parts of herba menthae, 5 to 20 parts of folium perillae and 5 to 20 parts of herba dendrobii. According to the traditional Chinese medicine fumigation bag, through formula design, a slow release technology and a double-layer packaging technology, the defects that in the prior art, the medicine effect is short, and components are prone to losing are overcome, and the effect of a traditional fumigation therapy method is remarkably improved.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of eye medication, and specifically relates to a traditional Chinese medicine fumigation bag for relieving eye fatigue and a preparation method and application thereof. BACKGROUND

[0002] With the change of modern lifestyle, long-time use of electronic devices leads to eye problems such as visual fatigue, dry eye syndrome, etc. Studies have shown that long-term staring at electronic screens can reduce the blinking frequency, affect tear secretion, and thus cause symptoms such as eye dryness, hyperemia, blurred vision, etc. Traditional Chinese medicine has unique advantages in relieving eye discomfort, among which traditional Chinese medicine fumigation therapy promotes eye blood circulation through warm steam and releases active ingredients of drugs, which can effectively relieve visual fatigue and improve microcirculation around the eyes.

[0003] At present, there are various traditional Chinese medicine fumigation products on the market to relieve eye fatigue, but they generally have the following technical defects: uneven release of drug efficacy, traditional fumigation bags usually use simple crushing and mixing method, the drug components are released too fast, cannot achieve long-term sustained release, resulting in short-acting effect; volatile components are prone to loss, the effective components (such as volatile oil) of aromatic herbs such as peppermint and perilla leaf are prone to volatilization during storage, affecting the stability of the product. For example, the common “chrysanthemum and medlar fumigation bag” or “cassia seed fumigation bag” on the market can relieve the symptoms to some extent, but the active ingredients are released quickly, the effect lasts for a short time, and there is no protection measure for volatile components, resulting in unstable effect of the product during storage and use.

[0004] In view of the above problems, it is urgent to develop a traditional Chinese medicine fumigation bag which can achieve slow release of drug components and prevent loss of effective components, so as to improve the clinical effect of fumigation therapy and better meet the needs of modern people to relieve eye fatigue. SUMMARY

[0005] In view of the deficiencies of the prior art, the present application discloses a traditional Chinese medicine fumigation bag for relieving eye fatigue and a preparation method and application thereof. The traditional Chinese medicine fumigation bag of the present application overcomes the defects of short-acting effect and loss of components in the prior art through formula design, slow-release technology and double-layer packaging process, and achieves significant improvement in the effect of traditional fumigation therapy.

[0006] To achieve the above-mentioned purpose, the present application provides the following technical solutions: A traditional Chinese medicine fumigation bag for relieving eye fatigue, comprising the following components by weight: 10-30 parts of wild chrysanthemum, 10-30 parts of frost mulberry leaf, 10-30 parts of cassia seed, 10-30 parts of gynostemma pentaphyllum, 5-20 parts of peppermint, 5-20 parts of perilla leaf, and 5-20 parts of dendrobium.

[0007] Preferably, the traditional Chinese medicine fumigation bag comprises the following components by weight: wild chrysanthemum 10-30 parts, frost mulberry leaf 10-30 parts, cassia seed 10-30 parts, gynostemma pentaphyllum 10-30 parts, mint 10-20 parts, perilla leaf 10-20 parts, and dendrobium 10-20 parts.

[0008] Preferably, the traditional Chinese medicine fumigation bag comprises the following components by weight: wild chrysanthemum 10-30 parts, frost mulberry leaf 10-30 parts, cassia seed 10-30 parts, gynostemma pentaphyllum 10-30 parts, mint 10-20 parts, perilla leaf 10-20 parts, and dendrobium 10-20 parts.

[0009] Preferably, the traditional Chinese medicine fumigation bag adopts a single-layer or double-layer composite packaging bag; the double-layer composite packaging bag encapsulates mint and perilla leaf powder in the inner layer, and encapsulates a mixture composed of wild chrysanthemum, frost mulberry leaf, cassia seed, gynostemma pentaphyllum, and dendrobium in the outer layer.

[0010] The present application provides a preparation method of the traditional Chinese medicine fumigation bag, comprising the following steps: S1. Dry and crush wild chrysanthemum, frost mulberry leaf, cassia seed, gynostemma pentaphyllum, mint, perilla leaf, and dendrobium to 20-60 mesh, preferably 40 mesh; S2. According to the above formula, sequentially weigh the powder of each medicinal material treated in step S1, mix them uniformly, and then pack them into a non-woven fabric bag or a cotton gauze bag with good air permeability to seal and prepare the fumigation bag.

[0011] The present application also provides a preparation method of the traditional Chinese medicine fumigation bag, comprising the following steps: a. Dry and crush wild chrysanthemum, frost mulberry leaf, gynostemma pentaphyllum, mint, and perilla leaf to 20-60 mesh to obtain the powder of the corresponding medicinal material; b. Perform β-cyclodextrin embedding treatment on cassia seed, and spray dry to obtain sustained-release cassia seed granules; c. Extract dendrobium with water, concentrate to obtain dry extract, and then mix with sodium alginate to spray granulate to obtain dendrobium sustained-release microspheres; d. Weigh the powder of wild chrysanthemum, frost mulberry leaf, gynostemma pentaphyllum, mint, and perilla leaf obtained in step a, the sustained-release cassia seed granules obtained in step b, and the dendrobium sustained-release microspheres obtained in step c according to the above component formula; e. Mix the powder of wild chrysanthemum, frost mulberry leaf, and gynostemma pentaphyllum with the sustained-release cassia seed granules and the dendrobium sustained-release microspheres uniformly to obtain an outer mixture; mix mint powder and perilla leaf powder uniformly to obtain an inner mixture; f. Pack the inner mixture into the inner layer of a double-layer composite packaging bag, and pack the outer mixture into the outer layer, and then seal to obtain the traditional Chinese medicine fumigation bag.

[0012] Preferably, in step b, the cassia seed is first fried and then crushed to 80-100 mesh, and then combined with a β-cyclodextrin solution for 4 h, and then spray dried.

[0013] Preferably, in step c, Dendrobium is added with 8-10 times the amount of water, extracted at 80-90 DEG C for 2 times, 1-2 hours each time, concentrated to a relative density of 1.10-1.20 at 60 DEG C, mixed with 3% sodium alginate solution, and spray dried to granules.

[0014] Preferably, in step f, the inner layer and the outer layer of the double-layer composite packaging bag are provided with a breathable barrier layer; the inner layer of the double-layer composite packaging bag is a soluble cellulose film, and the outer layer is a heat-resistant water-jet non-woven fabric; the breathable barrier layer is a microporous membrane or a high-density mesh fabric.

[0015] The application also provides the use of the above-mentioned Chinese herbal medicine fumigation bag in preparing an aerosol fumigation product for relieving visual fatigue or discomfort around the eyes.

[0016] Compared with the prior art, the application has the following beneficial effects: The Chinese herbal medicine fumigation bag of the application realizes a significant improvement in the effect of traditional fumigation therapy through innovative formula design, sustained-release technology and double-layer packaging process, and the improvement is embodied in the following aspects: (1) Realization of sustained release and synergistic effect of drug components: The application uses β-cyclodextrin embedding technology to process Cassiae Semen, and uses sodium alginate to prepare Dendrobium sustained-release microspheres, which effectively prolongs the release time of the effective components. At the same time, the volatile components of Mentha and Perilla frutescens are isolated from other medicinal materials by double-layer packaging, avoiding the rapid volatilization and loss of effective components. This combination of "sustained release" and "protection" technology makes the release of drug components stable and long-lasting during fumigation, significantly prolonging the action time, and thus better relieving eye fatigue and improving circulation around the eyes.

[0017] (2) Synergistic effect between components: The application selects medicinal materials such as wild chrysanthemum, frost mulberry leaves, Cassiae Semen, etc., among which wild chrysanthemum clears heat and resolves toxins, frost mulberry leaves dissipate wind-heat, Cassiae Semen clears liver and eyesight, Gynostemma pentaphyllum benefits qi and nourishes yin, Mentha and Perilla frutescens cool and refresh the brain, and Dendrobium nourishes yin and moistens dryness. The combination of these drugs can not only clear liver fire and dissipate wind-heat to relieve eye dryness and hyperemia, but also nourish yin and moisten dryness, and benefit qi and nourish yin to improve the consumption of yin fluid caused by long-time eye use. The components synergistically enhance each other to achieve the purpose of relieving visual fatigue and relieving eye discomfort.

[0018] (3) Innovation of structural design: The application adopts a unique double-layer composite packaging bag, which encapsulates volatile Mentha and Perilla frutescens powder in the inner layer and encapsulates sustained-release processed Cassiae Semen, Dendrobium and other medicinal materials in the outer layer. This design not only effectively protects volatile components, making the fumigation process more stable and long-lasting, but also greatly improves the use experience and clinical effect of the product.

[0019] To sum up, the traditional Chinese medicine fumigation bag of the present application realizes innovation in formula, process and structure, overcomes the defects of short-acting and easy loss of components in the prior art, and provides a better solution for relieving the eye fatigue of modern people. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative effort belong to the protection scope of the present application.

[0021] The present application discloses a traditional Chinese medicine fumigation bag for relieving eye fatigue, which comprises the following components by weight: 10-30 parts of wild chrysanthemum, 10-30 parts of frost mulberry leaves, 10-30 parts of cassia seed, 10-30 parts of gynostemma pentaphyllum, 5-20 parts of mint, 5-20 parts of perilla leaves, and 5-20 parts of dendrobium.

[0022] Preferably, the traditional Chinese medicine fumigation bag comprises the following components by weight: 10-30 parts of wild chrysanthemum, 10-30 parts of frost mulberry leaves, 10-30 parts of cassia seed, 10-30 parts of gynostemma pentaphyllum, 10-20 parts of mint, 10-20 parts of perilla leaves, and 10-20 parts of dendrobium.

[0023] The optimal formula of the components by weight of the traditional Chinese medicine fumigation bag is as follows: 20 parts of wild chrysanthemum, 20 parts of frost mulberry leaves, 20 parts of cassia seed, 20 parts of gynostemma pentaphyllum, 10 parts of mint, 10 parts of perilla leaves, and 10 parts of dendrobium.

[0024] The preparation method of the single-layer traditional Chinese medicine fumigation bag is as follows: S1. Dry and crush wild chrysanthemum, frost mulberry leaves, cassia seed, gynostemma pentaphyllum, mint, perilla leaves, and dendrobium to 20-60 mesh, preferably 40 mesh.

[0025] S2. According to the weight parts of 10-30 parts of wild chrysanthemum, 10-30 parts of frost mulberry leaves, 10-30 parts of cassia seed, 10-30 parts of gynostemma pentaphyllum, 5-20 parts of mint, 5-20 parts of perilla leaves, and 5-20 parts of dendrobium, sequentially take the powders of the processed medicinal materials in step S1, mix them evenly, and then put them into a non-woven fabric bag or a cotton gauze bag with good air permeability to seal and make a fumigation bag.

[0026] The preparation method of the double-layer traditional Chinese medicine fumigation bag is as follows: a. Dry and crush wild chrysanthemum, frost mulberry leaf, gynostemma, mint, perilla leaf to 20-60 mesh to obtain the corresponding medicinal powder.

[0027] b. First, fry the Cassia seed and then crush it to 80-100 mesh. Encapsulate it with β-cyclodextrin solution for 4 hours and spray dry to obtain the sustained-release Cassia seed granules.

[0028] c. Add 8-10 times the amount of water and extract at 80-90℃ for 2 times, 1-2 hours each time. Concentrate to a relative density of 1.10-1.20 at 60℃ (the relative density is measured by a densitometer in a 60℃ constant temperature water bath, which is used as the judgment standard for the end of concentration). Mix with 3% sodium alginate solution and spray dry to obtain the Dendrobium sustained-release microspheres.

[0029] d. According to the above formula, take 10-30 parts of wild chrysanthemum powder, 10-30 parts of frost mulberry leaf powder, 10-30 parts of gynostemma powder, 5-20 parts of mint powder, 5-20 parts of perilla leaf powder, 10-30 parts of sustained-release Cassia seed granules obtained in step b, and 5-20 parts of Dendrobium sustained-release microspheres obtained in step c.

[0030] e. Mix the wild chrysanthemum, frost mulberry leaf, and gynostemma powders with the sustained-release Cassia seed granules and Dendrobium sustained-release microspheres to obtain an outer mixture. Then mix the mint and perilla leaf powders to obtain an inner mixture.

[0031] f. Put the inner mixture into the inner layer of a double-layer composite packaging bag, and the outer mixture into the outer layer. Seal to obtain a traditional Chinese medicine fumigation bag.

[0032] The inner layer and the outer layer of the double-layer composite packaging bag are provided with a breathable barrier layer. The inner layer of the double-layer composite packaging bag is a soluble cellulose film, which can be hydroxypropyl methyl cellulose (HPMC) or sodium carboxymethyl cellulose (CMC-Na). The outer layer is a heat-resistant water-jet non-woven fabric, which can be polyester (PET) or polypropylene (PP). The breathable barrier layer is a microporous membrane or a high-density mesh fabric, such as a polytetrafluoroethylene (PTFE) membrane or a nylon mesh.

[0033] The application also provides the use of the above-mentioned Chinese herbal medicine fumigation bag in the preparation of an aerosol fumigation product for relieving visual fatigue or eye discomfort. The specific use method steps are as follows: ① Put the Chinese herbal medicine fumigation bag into the medicine compartment of an eye aerosol instrument and add 30-100 mL of water to fully soak the bag.

[0034] ② Start the eye aerosol instrument. The internal heating module of the instrument heats the liquid to 60-85℃ to generate fine and constant-temperature drug mist.

[0035] ③ User wears the matching eye mask or face mask of the atomizer, aims the mist outlet at the eyes and the surrounding area, closes the eyes and performs atomization fumigation, each time for 15-20 min.

[0036] ④ During the atomization process, the medicine mist penetrates through the skin around the eyes and the meridians, plays the roles of clearing heat and brightening eyes, dispelling wind and heat, and relieving visual fatigue.

[0037] ⑤ Use once a day, and continuously use for 5-7 days as a course of treatment.

[0038] ⑥ The same fumigation bag can be used once again within 24 h, and when used again, the water needs to be added again and the atomizer needs to be started.

[0039] The technical solutions of the present application are further described below in combination with specific examples: Example 1 The preparation method of the single-layer packaged traditional Chinese medicine fumigation bag in this example is as follows: S1. Dry and crush wild chrysanthemum, frost mulberry leaves, cassia seed, gynostemma, mint, perilla leaves and dendrobium to 40 mesh.

[0040] S2. According to the weight parts of wild chrysanthemum 20 parts, frost mulberry leaves 20 parts, cassia seed 20 parts, gynostemma 20 parts, mint 10 parts, perilla leaves 10 parts and dendrobium 10 parts, the powders of the processed medicinal materials in step S1 are sequentially weighed and mixed uniformly, and then are loaded into non-woven fabric bags with good air permeability, and are sealed to form fumigation bags.

[0041] Example 2 The preparation method of the single-layer packaged traditional Chinese medicine fumigation bag in this example is as follows: S1. Dry and crush wild chrysanthemum, frost mulberry leaves, cassia seed, gynostemma, mint, perilla leaves and dendrobium to 20 mesh.

[0042] S2. According to the weight parts of wild chrysanthemum 10 parts, frost mulberry leaves 10 parts, cassia seed 10 parts, gynostemma 10 parts, mint 5 parts, perilla leaves 5 parts and dendrobium 5 parts, the powders of the processed medicinal materials in step S1 are sequentially weighed and mixed uniformly, and then are loaded into cotton gauze bags with good air permeability, and are sealed to form fumigation bags.

[0043] Example 3 The preparation method of the single-layer packaged traditional Chinese medicine fumigation bag in this example is as follows: S1. Dry and crush wild chrysanthemum, frost mulberry leaves, cassia seed, gynostemma, mint, perilla leaves and dendrobium to 60 mesh.

[0044] S2. According to the weight parts of wild chrysanthemum 30 parts, frost mulberry leaf 30 parts, cassia seed 30 parts, gynostemma 30 parts, mint 20 parts, perilla leaf 20 parts, and dendrobium 20 parts, the powders of the respective medicinal materials treated in step S1 were sequentially weighed and mixed uniformly, and then were loaded into cotton gauze bags with good air permeability to seal and prepare fumigation bags.

[0045] Example 4 The present example is a preparation method of a traditional Chinese medicine fumigation bag with sustained-release granules and double-layer packaging, and the specific steps are as follows: a. Wild chrysanthemum, frost mulberry leaf, gynostemma, mint, and perilla leaf were dried at 40°C for 6h, and then were ground to 40 mesh and sieved for use, to obtain the corresponding medicinal material powders.

[0046] b. The cassia seed was stir-fried until slightly yellow, and then was ground and sieved through a 90-mesh sieve. The sieved cassia seed powder was mixed with 3% β-cyclodextrin aqueous solution at a mass ratio of 1:4, and then was spray dried (inlet air temperature 160°C, outlet air temperature 80°C) to obtain powder-like sustained-release cassia seed granules.

[0047] c. The dendrobium was added with 9 times the amount of water, and was reflux extracted at 85°C for 2 times, each for 1.5h. The extraction liquids were combined, and were concentrated under reduced pressure to 60°C with a relative density of 1.15. Then, the concentrated liquid was mixed with 3% sodium alginate solution at a volume ratio of 1:1, and was stirred uniformly, and then was spray dried (inlet air temperature 180°C, outlet air temperature 85°C) to obtain dendrobium sustained-release microspheres.

[0048] d. According to the above formula, wild chrysanthemum powder 20 parts, frost mulberry leaf powder 20 parts, gynostemma powder 20 parts, mint powder 10 parts, perilla leaf powder 10 parts, sustained-release cassia seed granules 20 parts obtained in step b, and dendrobium sustained-release microspheres 10 parts obtained in step c were weighed.

[0049] e. The wild chrysanthemum powder, frost mulberry leaf powder, gynostemma powder, sustained-release cassia seed granules, and dendrobium sustained-release microspheres weighed in step d were mixed uniformly to obtain an outer layer mixture. The mint powder and perilla leaf powder were mixed uniformly to obtain an inner layer mixture.

[0050] f. The inner layer mixture was loaded into an inner layer bag made of hydroxypropyl methyl cellulose (HPMC E50) film with a thickness of 0.03mm. The outer layer mixture was loaded into an outer layer bag made of polyester (PET) heat-resistant water-jet non-woven fabric with a grammage of 30g / m² and a heat resistance of up to 120°C. A polytetrafluoroethylene (PTFE) film was arranged as an air-permeable separation layer between the inner layer and the outer layer. Finally, the fumigation bag was sealed.

[0051] Example 5 The present example is a preparation method of a traditional Chinese medicine fumigation bag with sustained-release granules and double-layer packaging, and the specific steps are as follows: a. Dry wild chrysanthemum, frost mulberry leaves, gynostemma, mint, perilla leaves at 40°C for 6h, and crush to 20 mesh, sieve and reserve to obtain corresponding medicinal powder.

[0052] b. Roast cassia seed until slightly yellow, crush, and sieve through an 80 mesh sieve. Mix the sieved cassia seed powder with 3% β-cyclodextrin water solution at a mass ratio of 1:4, and spray dry (inlet temperature 160°C, outlet temperature 80°C) to obtain powder-like sustained-release cassia seed granules.

[0053] c. Take dendrobium with 8 times the amount of water, reflux extract at 80°C for 2 times, 1h each time. Combine the extract, and concentrate under reduced pressure to 60°C relative density 1.10. Then mix the concentrated solution with 3% sodium alginate solution at a volume ratio of 1:1, and stir evenly. Spray dry (inlet temperature 180°C, outlet temperature 85°C) to obtain dendrobium sustained-release microspheres.

[0054] d. According to the above formula, take 10 parts of wild chrysanthemum powder, 10 parts of frost mulberry leaf powder, 10 parts of gynostemma powder, 5 parts of mint powder, 5 parts of perilla leaf powder, 10 parts of sustained-release cassia seed granules obtained in step b, and 5 parts of dendrobium sustained-release microspheres obtained in step c.

[0055] e. Mix the wild chrysanthemum powder, frost mulberry leaf powder, gynostemma powder, sustained-release cassia seed granules, and dendrobium sustained-release microspheres taken in step d evenly to obtain an outer mixture. Mix the mint powder and perilla leaf powder evenly to obtain an inner mixture.

[0056] f. Put the inner mixture into an inner bag made of hydroxypropyl methylcellulose (HPMC E50) film with a thickness of 0.03mm; then put the outer mixture into an outer bag made of polyester (PET) heat-resistant water-jet non-woven fabric with a grammage of 30g / m² and a heat resistance of up to 120°C; set a polytetrafluoroethylene (PTFE) film as a breathable barrier layer between the inner and outer layers, and finally seal to obtain a traditional Chinese medicine fumigation bag.

[0057] Example 6 This example is a preparation method of a traditional Chinese medicine fumigation bag with sustained-release granules and double-layer packaging, and the specific steps are as follows: a. Dry wild chrysanthemum, frost mulberry leaves, gynostemma, mint, perilla leaves at 40°C for 6h, and crush to 60 mesh, sieve and reserve to obtain corresponding medicinal powder.

[0058] b. Roast cassia seed until slightly yellow, crush, and sieve through a 100 mesh sieve. Mix the sieved cassia seed powder with 3% β-cyclodextrin water solution at a mass ratio of 1:4, and spray dry (inlet temperature 160°C, outlet temperature 80°C) to obtain powder-like sustained-release cassia seed granules.

[0059] c. Dendrobium nobile Lindl. was extracted with 10 times the amount of water at 80℃ for 2 hours, and the extraction was repeated twice. The combined extract was concentrated under reduced pressure to a relative density of 1.20 at 60℃. Then the concentrated solution was mixed with 3% sodium alginate solution at a volume ratio of 1:1, and stirred uniformly. Spray drying was performed (inlet temperature 180℃, outlet temperature 85℃) to obtain Dendrobium nobile sustained-release microspheres.

[0060] d. According to the above formula, 30 parts of wild chrysanthemum powder, 30 parts of mulberry leaf powder, 30 parts of Gynostemma pentaphyllum powder, 20 parts of peppermint powder, 20 parts of perilla leaf powder, 30 parts of sustained-release Cassia acutifolia granules obtained in step b, and 20 parts of Dendrobium nobile sustained-release microspheres obtained in step c were weighed.

[0061] e. The wild chrysanthemum powder, mulberry leaf powder, and Gynostemma pentaphyllum powder weighed in step d were mixed uniformly with the sustained-release Cassia acutifolia granules and Dendrobium nobile sustained-release microspheres to obtain an outer mixture. The peppermint powder and perilla leaf powder were mixed uniformly to obtain an inner mixture.

[0062] f. The inner mixture was placed in an inner bag made of a hydroxypropyl methylcellulose (HPMC E50) film with a thickness of 0.03 mm. The outer mixture was placed in an outer bag made of a polyester (PET) heat-resistant water-jet non-woven fabric with a grammage of 30 g / m² and a heat resistance of up to 120℃. A polytetrafluoroethylene (PTFE) film was placed as a breathable barrier between the inner and outer layers, and finally sealed to obtain a traditional Chinese medicine fumigation bag.

[0063] Example 7 This example is to evaluate the use effect of the traditional Chinese medicine fumigation bag prepared in Examples 1-3.

[0064] To verify the use effect of the traditional Chinese medicine fumigation bag of the present application, the fumigation bags prepared in Examples 1-3 were selected for effect evaluation on people who often use their eyes (such as subjects who experience visual fatigue due to long-term computer use and people who stay up late watching mobile phones). The test population was randomly divided into a test group (30 people) and a control group (30 people), and the test group was further divided into three groups: a first test group (using the fumigation bag prepared in Example 1), a second test group (using the fumigation bag prepared in Example 2), and a third test group (using the fumigation bag prepared in Example 3); the control group used a common warm water atomizer without medicine.

[0065] The specific use method is as follows: ① The traditional Chinese medicine fumigation bags prepared in Examples 1-3 were respectively placed in the medicine bin of an eye atomizer, and 80 mL of clean water was added to fully soak the medicine bags.

[0066] ② The eye atomizer was started, and the internal heating module of the instrument heated the medicine liquid to 70℃ to generate fine and constant-temperature medicine mist.

[0067] ③ User wears the matching eye mask of the atomization instrument, aims the mist outlet at the eyes and the surrounding area, closes the eyes for atomization fumigation, each time for 20 min; during the atomization process, the drug mist penetrates through the skin and meridians around the eyes, plays the roles of clearing heat and brightening eyes, dispelling wind and heat, and relieving visual fatigue.

[0068] ④ Use once a day, and continuously use for 7 days as a course of treatment.

[0069] ⑤ The same fumigation bag can be used once within 24 h, and when used again, water needs to be added and the atomization instrument needs to be started.

[0070] Evaluation method: Subjective scoring method: The visual analogue scale (VAS) is used to evaluate the degrees of “dry eyes”, “sore eyes”, and “swollen and painful eyes”, and the subjects score their own degrees of “dry eyes”, “sore eyes”, and “swollen and painful eyes” on a scale of 0-10 (0 represents no discomfort, and 10 represents the most severe discomfort). Finally, the average score of each group of subjects is calculated.

[0071] Objective examination index: Uncorrected visual acuity (UCVA) records the best visual acuity of the subjects without wearing glasses; tear film break-up time (BUT) evaluates the stability of the tear film and measures the time from the appearance of the first dry spot on the tear film surface after blinking. Finally, the average value of each group of subjects is calculated.

[0072] Evaluation time: Evaluation is carried out before the use of the traditional Chinese medicine fumigation bag (baseline), after the use of one course of treatment (7 days), and after the use of two courses of treatment (14 days). The evaluation results are shown in Table 1.

[0073] Table 1 As can be seen from Table 1, all the test groups are significantly better than the control group in improving the symptoms of “dry eyes”, “sore eyes”, and “swollen and painful eyes” and prolonging the tear film break-up time (BUT), and the improvement effect is more obvious with the increase of the treatment course. At the same time, the uncorrected visual acuity (UCVA) of the subjects in all the test groups shows a slight upward trend. This shows that the traditional Chinese medicine fumigation bag of the application not only can effectively relieve the symptoms related to dry eye syndrome, but also can significantly improve the stability of the tear film, thereby effectively improving the dry eye state.

[0074] Example 8 This example is to evaluate the use effect of the traditional Chinese medicine fumigation bag prepared in the above Examples 4-5.

[0075] To verify the use effect of the traditional Chinese medicine fumigation bag in the present application, the fumigation bags prepared in Examples 4-5 are selected to evaluate the effect on people who often use their eyes (such as subjects who have visual fatigue caused by long-time use of computers and people who stay up late to watch mobile phones). The test population is randomly divided into a test group (30 people) and a control group (30 people), wherein the test group is further divided into three groups: a fourth test group (using the fumigation bag prepared in Example 4), a fifth test group (using the fumigation bag prepared in Example 5), and a sixth test group (using the fumigation bag prepared in Example 6); the control group uses a common warm water atomizer without medicine.

[0076] The specific use method is as follows: ①The traditional Chinese medicine fumigation bags prepared in Examples 4-5 are respectively loaded into the medicine bin of the eye atomizer, and 80 mL of water is added to fully soak the medicine bag.

[0077] ②The eye atomizer is started, and the internal heating module of the instrument heats the medicine liquid to 70℃ to generate fine and constant-temperature medicine mist.

[0078] ③The user wears the matching eye mask of the atomizer, aims the mist outlet at the eyes and the eye area, closes the eyes to perform fumigation and steaming, and each time lasts for 20 min; during the atomization process, the medicine mist penetrates through the skin and meridians around the eyes to play the roles of clearing heat and brightening eyes, dispelling wind and heat, and relieving visual fatigue.

[0079] ④It is used once a day, and a course of treatment is 7 days of continuous use.

[0080] ⑤The same fumigation bag can be used again once within 24 h, and water needs to be added again and the atomizer needs to be started for the next use.

[0081] Evaluation method: Subjective scoring method: The visual analogue scale (VAS) is used to evaluate the degrees of “dry eyes”, “sore eyes”, and “swollen and painful eyes”, and the subjects score the degrees of “dry eyes”, “sore eyes”, and “swollen and painful eyes” on a scale of 0-10 (0 represents no discomfort, and 10 represents the most severe discomfort). The average score of each group of subjects is finally calculated.

[0082] Objective examination index: uncorrected visual acuity (UCVA) is recorded, naked eye visual acuity (UCVA) is recorded, and the best visual acuity of the subjects without wearing glasses is recorded; tear film break-up time (BUT) is evaluated, and the stability of the tear film is evaluated, and the time from the appearance of the first dry spot on the surface of the tear film after blinking is measured. The average value of each group of subjects is finally calculated.

[0083] Evaluation time: evaluation is performed before the use of the traditional Chinese medicine fumigation bag (baseline), after the use of one course of treatment (7 days), and after the use of two courses of treatment (14 days). The evaluation results are shown in Table 2.

[0084] Table 2 As can be seen from Table 2, the treatment scheme of the present application (Examples 4, 5, and 6) has a significant effect on dry eye, and is superior to the conventional control treatment; Example 4 (the fourth test group) is the optimal formula or process, and performs best in terms of symptom relief, vision improvement, and tear film stability improvement; the treatment effect is enhanced with an increase in the treatment course, and the effect is more stable after two treatment courses; the scheme can effectively improve the ocular discomfort of dry eye patients, improve the visual quality, and enhance the tear film stability.

[0085] The above has described in detail the traditional Chinese medicine fumigation bag for relieving ocular fatigue, and its preparation method and application. The principles and implementation modes of the present application are described by applying specific examples, and the above examples are only used to help understand the method of the present application and its core idea. It should be pointed out that, for those skilled in the art, some improvements and modifications can be made to the present application without departing from the principles of the present application, and these improvements and modifications also fall within the protection scope of the claims of the present application.

Claims

1. A traditional Chinese medicine fumigation bag for relieving eye fatigue, characterized in that, The traditional Chinese medicine fumigation bag comprises the following components in parts by weight: wild chrysanthemum 10-30 parts, frost mulberry leaves 10-30 parts, cassia seed 10-30 parts, gynostemma 10-30 parts, mint 5-20 parts, perilla leaves 5-20 parts, and dendrobium 5-20 parts.

2. The traditional Chinese medicine fumigation bag for relieving eye fatigue according to claim 1, characterized in that, The traditional Chinese medicine fumigation bag comprises the following components in parts by weight: wild chrysanthemum 10-30 parts, frost mulberry leaves 10-30 parts, cassia seed 10-30 parts, gynostemma 10-30 parts, mint 10-20 parts, perilla leaves 10-20 parts, and dendrobium 10-20 parts.

3. The traditional Chinese medicine fumigation bag for relieving eye fatigue according to claim 2, characterized in that, The traditional Chinese medicine fumigation bag comprises the following components in parts by weight: wild chrysanthemum 10-30 parts, frost mulberry leaves 10-30 parts, cassia seed 10-30 parts, gynostemma 10-30 parts, mint 10-20 parts, perilla leaves 10-20 parts, and dendrobium 10-20 parts.

4. The traditional Chinese medicine fumigation bag according to any one of claims 1 to 3, characterized in that, The traditional Chinese medicine fumigation bag comprises the following components in parts by weight: wild chrysanthemum 10-30 parts, frost mulberry leaves 10-30 parts, cassia seed 10-30 parts, gynostemma 10-30 parts, mint 10-20 parts, perilla leaves 10-20 parts, and dendrobium 10-20 parts.

5. A method for preparing the traditional Chinese medicine fumigation bag according to any one of claims 1 to 3, characterized in that, The method comprises the following steps: S1. Dry and crush wild chrysanthemum, frost mulberry leaves, cassia seed, gynostemma, mint, perilla leaves, and dendrobium to 20-60 mesh; S2. According to the formula of any one of claims 1-3, sequentially weigh the powders of the processed medicinal materials of step S1, mix them uniformly, and then put them into a non-woven fabric bag or a cotton gauze bag with good air permeability, and seal to prepare a fumigation bag.

6. A preparation method of the traditional Chinese medicine fumigation bag according to any one of claims 1 to 3, characterized in that, The method comprises the following steps: a. Dry and crush wild chrysanthemum, frost mulberry leaves, gynostemma, mint, and perilla leaves to 20-60 mesh to obtain powders of the corresponding medicinal materials; b. Perform β-cyclodextrin embedding treatment on cassia seed, and spray dry to prepare sustained-release cassia seed granules; c. Extract dendrobium with water, concentrate to obtain dry extract, and then mix with sodium alginate and spray granulate to obtain dendrobium sustained-release microspheres; d. According to the formula of any one of claims 1-3, weigh the powders of wild chrysanthemum, frost mulberry leaves, gynostemma, mint, and perilla leaves obtained in step a, the sustained-release cassia seed granules obtained in step b, and the dendrobium sustained-release microspheres obtained in step c; e. Mix the powders of wild chrysanthemum, frost mulberry leaves, and gynostemma with the sustained-release cassia seed granules and the dendrobium sustained-release microspheres to obtain an outer mixture, and mix the powders of mint and perilla leaves to obtain an inner mixture; f. Put the inner mixture into the inner layer of a double-layer composite packaging bag, put the outer mixture into the outer layer, and seal to obtain a traditional Chinese medicine fumigation bag.

7. The production method according to claim 6, wherein In step b, the cassia seed is first fried and then crushed to 80-100 mesh, and then combined with a β-cyclodextrin solution for 4 hours, and then spray dried.

8. The preparation method according to claim 6, characterized in that, In step c, the dendrobium is extracted with 8-10 times the amount of water at 80-90°C for 2 times, each for 1-2 hours, and then concentrated to a relative density of 1.10-1.20 at 60°C, mixed with a 3% sodium alginate solution, and then spray dried and granulated.

9. The preparation method according to claim 6, characterized in that, In step f, the inner layer and the outer layer of the double-layer composite packaging bag are provided with an air-permeable separation layer; the inner layer of the double-layer composite packaging bag is a soluble cellulose film, and the outer layer is a heat-resistant water-jet non-woven fabric; and the air-permeable separation layer is a microporous film or a high-density mesh fabric.

10. Use of the Chinese herbal medicine fumigation bag according to any one of claims 1-3 in the preparation of an aerosol fumigation product for relieving visual fatigue or discomfort around the eyes.

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