Quick response type nutrient composition for cognitive load scene as well as preparation method and application of quick response type nutrient composition
By preparing a nutrient composition containing L-α-glucosinolate, disodium pyrroloquinoline quinone, blueberry anthocyanins, γ-aminobutyric acid, L-lysine, and L-arginine, the problems of slow response and single effect of traditional nutritional supplements are solved, achieving rapid response and multi-target synergistic effect, improving cognitive ability and reducing error rate.
Patent Information
- Application Number
- CN202511907395.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-17
- Publication Date
- 2026-01-23
AI Technical Summary
Traditional nutritional supplements or Chinese medicine compositions have low absorption and bioavailability, slow response, single effect and slow onset of action, making it difficult to meet the rapid response needs in cognitive load scenarios.
Using L-α-glycine choline, disodium pyrroloquinoline quinone, blueberry anthocyanins, γ-aminobutyric acid, L-lysine, and L-arginine as the main components, a liquid dosage form is prepared through a specific preparation method, including steps such as dissolution, filtration, sterilization, and filling, to form a nutrient composition with multi-target synergistic effects.
It achieves rapid absorption and bioavailability, can improve cognitive ability in a short time, quickly relieve fatigue, enhance mental agility, and reduce error rate, making it suitable for high-intensity cognitive load scenarios.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application belongs to the technical field of food processing, and relates to a fast-responding nutrient composition for cognitive load scenarios and a preparation method and application thereof. BACKGROUND
[0002] The high-pressure and fast-paced work and study environment of contemporary society has given rise to a large number of instant cognitive enhancement needs. For example, the student group faces high-intensity mental consumption in the entrance examination, and the professional groups such as financial practitioners and scientific researchers need to maintain high concentration and decision-making ability for a long time, and medical personnel, emergency command personnel and the like are often in a sudden high-pressure cognitive scenario. The common feature of these scenarios is that the brain needs to process a large amount of information in a short time and continuously output optimal decisions, resulting in a sharp increase in cognitive load. When the cognitive demand exceeds the individual processing capacity, a series of neural efficiency decline phenomena such as attention dispersion, memory extraction delay and judgment decline will be caused. Neuro-nutritional supplements or traditional Chinese medicine compositions are emerging to solve such needs.
[0003] However, the traditional neuro-nutritional supplements or traditional Chinese medicine compositions have a series of problems. First, there is a problem of low absorption and bioavailability. For example, the traditional Chinese medicine composition needs to be taken for a long time, and the effect is obvious generally after half a month, which cannot meet the demand of fast response in the cognitive load scenario. Second, the action is single. The existing products are mainly aimed at single mechanism, mainly aimed at relieving body fatigue, and the effect on central fatigue is limited, and there is a lack of multi-target synergistic effect, resulting in single and limited effect. Finally, there is a problem of dosage form. Traditional products are mostly in the form of pills, which are inconvenient to take and slow to take effect. In summary, the traditional nutritional supplement scheme is difficult to meet the instant demand for cognitive enhancement due to the problems of low absorption and bioavailability, slow response, single and limited effect, and slow effect. Therefore, it is of great significance to develop a composition with high absorption and bioavailability, fast response, multi-target synergistic effect and fast effect for cognitive load scenarios. SUMMARY
[0004] The present application aims to provide a fast-responding nutrient composition for cognitive load scenarios and a preparation method and application thereof, so as to solve the technical problems of low absorption and bioavailability, slow response, limited effect and slow effect of the traditional nutritional supplements or traditional Chinese medicine compositions.
[0005] To solve the above technical problems, the technical scheme adopted by the present application is to provide a fast-responding nutrient composition for cognitive load scenarios, which comprises the following raw materials in parts by weight: L-alpha-glycero-phosphocholine 400-600 parts, pyrroloquinoline quinone disodium salt 0.1-0.4 parts, blueberry anthocyanin 4-6 parts, gamma-aminobutyric acid 4-6 parts, L-lysine 4-6 parts, and L-arginine 4-6 parts.
[0006] Preferably, the auxiliary material further comprises purified water and a flavoring auxiliary material.
[0007] The second aspect of the present application provides a preparation method of the rapid response nutrient composition for cognitive load scenarios as described above, comprising the following steps: (1) dissolving L-α-glycerophosphocholine, pyrroloquinoline quinone disodium salt and blueberry anthocyanin in purified water as a dissolving solvent to obtain solution A; (2) dissolving γ-aminobutyric acid, L-lysine and L-arginine in 50℃ purified water, stirring until clear to obtain solution B; (3) stirring and mixing solution A, solution B and the flavoring auxiliary material to obtain solution C; (4) filtering solution C once; (5) using purified water to set the volume of the filtered solution C and stirring to mix evenly; (6) ultrahigh temperature instant sterilization of the set volume solution C; (7) secondary filtration and filling of the ultrahigh temperature instant sterilized solution C; (8) pasteurization of the filled solution C to obtain the nutrient composition.
[0008] Preferably, in step (3), stirring for 10-30min.
[0009] Preferably, in step (4), using a 200 mesh filter screen for the first filtration.
[0010] Preferably, in step (5), using purified water to set the volume to a target soluble solid content of 10-50%, and stirring for 10-30min.
[0011] Preferably, in step (6), using a UHT sterilizer for ultrahigh temperature instant sterilization, setting the sterilization temperature to 120-130℃, the time to 8-15s, and the outlet temperature of the UHT sterilizer to 25-35℃.
[0012] Preferably, in step (7), using a 100 mesh filter screen for the second filtration.
[0013] Preferably, in step (8), the pasteurization temperature is 80-90℃ and the time is 15-25min.
[0014] The third aspect of the present application provides an application of the rapid response nutrient composition for cognitive load scenarios as described above, for preparing a food for rapidly enhancing cognition.
[0015] L-α-GPC is a metabolic intermediate of phosphatidylcholine. Traditional choline precursors (such as choline chloride) need to be converted into phosphatidylcholine through the CDP-choline synthesis pathway, which is limited by the rate-limiting enzyme and has low efficiency. L-α-GPC can bypass the rate-limiting step of CDP-choline synthesis and quickly enter neurons in a "direct" mode. Studies have shown that oral administration of L-α-GPC can increase the concentration of acetylcholine in the brain by 250% within 30 minutes, while traditional choline precursors take more than 2 hours to achieve similar results, reflecting its efficiency and timeliness. In the dual-task test (such as handling memory and attention tasks at the same time), L-α-GPC can reduce the error rate by 38%, while choline alone can only reduce it by 12%. The difference is due to the targeted activation of the central cholinergic system, especially in scenarios that require multi-task processing capabilities (such as learning and working memory enhancement).
[0016] Pyrroloquinoline quinone disodium salt (PQQ disodium salt) has both coenzyme and antioxidant properties. L-α-GPC is a "master switch" transcriptional coactivator for mitochondrial biogenesis, and PQQ disodium salt activates L-α-GPC through the AMPK / mTOR signaling pathway, driving the coordinated expression of nuclear genes and mitochondrial DNA, and promoting mitochondrial biogenesis. Studies have shown that PQQ disodium salt can increase intracellular ATP production by 55% within 3 hours, which is due to its direct regulation of the activity of mitochondrial respiratory chain complexes. In addition, PQQ disodium salt has free radical scavenging ability beyond traditional antioxidants, with a superoxide radical scavenging efficiency 5000 times that of vitamin C. PQQ disodium salt not only scavenges free radicals, but also acts as an oxidation-reduction signal molecule to induce the expression of intracellular antioxidant enzymes (such as SOD and CAT), forming a "scavenging + defense" dual mechanism. Furthermore, PQQ disodium salt can promote neuronal mitochondrial renewal and improve synaptic plasticity, and can reverse memory decline caused by aging in animal experiments.
[0017] The polyphenol hydroxyl group in the structure of blueberry anthocyanins confers strong antioxidant capacity, and glycosylation modification enhances intestinal absorption stability. Blueberry anthocyanins can specifically reduce the release of TNF-α from microglial cells by inhibiting the NF-κB signaling pathway, and experiments have shown that it can reduce the level of neuroinflammatory factors by 68%. Blueberry anthocyanins can activate TrkB receptor phosphorylation and promote the expression of brain-derived neurotrophic factor (BDNF) gene, promoting synaptic plasticity. BDNF, as a key factor in synaptic plasticity, can promote the formation of neuronal dendritic spines and enhance LTP, increasing the speed of storing new information in the brain.
[0018] Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, which is generated from glutamate by glutamate decarboxylase (GAD) and can activate GABA_B receptor, inhibit excessive release of glutamate and reduce stress cortisol by 42%. EEG verification shows that gamma-aminobutyric acid can increase alpha brain wave power by 37% and promote relaxed alertness.
[0019] L-lysine has the function of energy-transmitter dual regulation, and as a PQQ disodium salt chelate carrier, it has a stable quinone structure and can prevent degradation in the stomach. fMRI verification shows that L-lysine can increase brain blood flow by 45% and improve oxygenation.
[0020] L-arginine is a cerebral vasodilator that can produce NO through NOS catalysis, and can dilate cerebral microvessels within 3 minutes. In addition, L-arginine can also increase the gray matter blood oxygen level dependent (BOLD) signal intensity, and fMRI shows that the BOLD signal intensity is increased by 29%.
[0021] The present application provides a kind of fast response type nutrient composition for cognitive load scene and its preparation method and application, compared with prior art, the beneficial effects of the present application are: (1) the present application uses L-α-glycero-phosphocholine, PQQ disodium salt, blueberry anthocyanin, gamma-aminobutyric acid, L-lysine and L-arginine as raw materials to prepare nutrient composition, PQQ disodium salt, blueberry anthocyanin, L-lysine and L-arginine synergistically promote energy metabolism of nerve cells; L-α-glycero-phosphocholine and gamma-aminobutyric acid synergistically regulate neurotransmitter levels, improve cognitive ability while preventing excessive excitation of nerves; PQQ disodium salt and blueberry anthocyanin synergistically provide oxidative protection for nerve cells; the above six components synergistically form a "nerve cell energy metabolism-neurotransmitter balance-oxidative protection" three-pathway synergistic mechanism, through multi-target synergistic effect, the prepared nutrient composition has multiple effects of improving cognitive decline symptoms, quickly relieving cognitive fatigue, improving thinking agility and reducing error rate, especially suitable for high-intensity cognitive load scenarios.
[0022] (2) the present application selects high bioavailability ingredients as raw materials, improves the absorption and bioavailability of the nutrient composition, can achieve rapid response, and has good effect on improving cognition; the present application designs the dosage form as a liquid dosage form, which is easy to absorb, has rapid effect and is convenient to take.
[0023] (3) The present application breaks through the three shackles of slow effect, single action and dependence on stimulants of existing products, and provides a safe, fast and efficient neurotrophic solution for high-intensity cognitive load scenarios; compared with traditional Chinese medicine compounds, the nutrient composition of the present application is based on the synergistic effect of the three pathways of "neural cell energy metabolism-neurotransmitter balance-oxidative protection", and with the aid of dosage form, it innovatively realizes the order of magnitude improvement of clinical response speed; compared with the chemical stimulant scheme, the nutrient composition of the present application avoids drug dependence and cardiovascular risk through physiological regulation mechanism, and opens up a new path for the field of cognitive enhancement.
[0024] The present application is suitable for cognitive enhancement in various scenarios such as professional high-intensity mental work scenarios, education and competition fields, special environment operations, neurofunctional rehabilitation assistance, health management upgrade market, etc. DETAILED DESCRIPTION
[0025] In order to make the technical problems, technical solutions and beneficial effects of the present application clearer, the present application will be further described in detail below in combination with examples. It should be understood that the specific examples described herein are only used to explain the present application and not to limit the present application. The methods used in the present application are conventional methods unless otherwise specified; the raw materials and devices used are conventional commercially available products unless otherwise specified.
[0026] In order to confirm the reliability of the effect of the present application, the present application will be described below in combination with Examples 1-6, and compared with Comparative Examples 1-8.
[0027] Example 1 The present embodiment provides a fast-responding nutrient composition for cognitive load scenarios, which comprises the following raw materials by weight: L-alpha-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.2 mg, blueberry anthocyanin 5 mg, gamma-aminobutyric acid 5 mg, L-lysine 5 mg, L-arginine 5 mg.
[0028] The present embodiment also provides a preparation method of the fast-responding nutrient composition for cognitive load scenarios described above, comprising the following steps: (1) Dissolve L-alpha-glycerophosphocholine, pyrroloquinoline quinone disodium salt and blueberry anthocyanin with purified water as the dissolving solvent to obtain solution A; (2) Dissolve gamma-aminobutyric acid, L-lysine and L-arginine with 50℃ purified water, stir until clear to obtain solution B; (3) Mix solution A, solution B and 300 mL flavoring material, stir for 15 min to obtain solution C; (4) Filter solution C once with a 200 mesh filter screen; (5) The solution C after the first filtration is made up to a total volume of 1000 mL using purified water, and the target soluble solid content is 30%, and stirred for 20 min to mix evenly; (6) The solution C after the making up is subjected to ultra-high temperature instant sterilization using a UHT sterilizer, the sterilization temperature is 125°C, the time is 10 s, and the outlet temperature of the UHT sterilizer is 30°C; (7) The solution C after the ultra-high temperature instant sterilization is subjected to secondary filtration and filling using a 100-mesh filter screen; (8) The solution C after the filling is subjected to pasteurization, the sterilization temperature is 85°C, the time is 20 min, and the nutrient composition is obtained after the sterilization.
[0029] Example 2 The difference between this example and Example 1 is that the nutrient composition comprises the following weights of raw materials: L-α-glycerophosphocholine 400 mg, pyrroloquinoline quinone disodium salt 0.4 mg, blueberry anthocyanin 6 mg, γ-aminobutyric acid 4 mg, L-lysine 6 mg, and L-arginine 4 mg; the rest of the operations are the same, and finally the nutrient composition is obtained.
[0030] Example 3 The difference between this example and Example 1 is that the nutrient composition comprises the following weights of raw materials: L-α-glycerophosphocholine 500 mg, pyrroloquinoline quinone disodium salt 0.1 mg, blueberry anthocyanin 4 mg, γ-aminobutyric acid 6 mg, L-lysine 4 mg, and L-arginine 6 mg; the rest of the operations are the same, and finally the nutrient composition is obtained.
[0031] Example 4 The difference between this example and Example 1 is that the nutrient composition comprises the following weights of raw materials: L-α-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.4 mg, blueberry anthocyanin 4 mg, γ-aminobutyric acid 5 mg, L-lysine 6 mg, and L-arginine 4 mg; the rest of the operations are the same, and finally the nutrient composition is obtained.
[0032] Example 5 The difference between this example and Example 1 is that the nutrient composition comprises the following weights of raw materials: L-α-glycerophosphocholine 400 mg, pyrroloquinoline quinone disodium salt 0.4 mg, blueberry anthocyanin 5 mg, γ-aminobutyric acid 6 mg, L-lysine 5 mg, and L-arginine 6 mg; the rest of the operations are the same, and finally the nutrient composition is obtained.
[0033] Example 6 The present example is different from Example 1 in that the nutrient composition includes the following amounts by weight of raw materials: L-a-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.4 mg, blueberry anthocyanin 6 mg, gamma-aminobutyric acid 6 mg, L-lysine 6 mg, L-arginine 6 mg; and the remaining operations are the same, and finally the nutrient composition is obtained.
[0034] Comparative Example 1 The present comparative example is different from Example 1 in that pyrroloquinoline quinone disodium salt is not added to the nutrient composition, i.e., the nutrient composition includes the following amounts by weight of raw materials: L-a-glycerophosphocholine 600 mg, blueberry anthocyanin 5 mg, gamma-aminobutyric acid 5 mg, L-lysine 5 mg, L-arginine 5 mg; and the remaining operations are the same, and finally the nutrient composition is obtained.
[0035] Comparative Example 2 The present comparative example is different from Example 1 in that blueberry anthocyanin is not added to the nutrient composition, i.e., the nutrient composition includes the following amounts by weight of raw materials: L-a-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.2 mg, gamma-aminobutyric acid 5 mg, L-lysine 5 mg, L-arginine 5 mg; and the remaining operations are the same, and finally the nutrient composition is obtained.
[0036] Comparative Example 3 The present comparative example is different from Example 1 in that L-lysine is not added to the nutrient composition, i.e., the nutrient composition includes the following amounts by weight of raw materials: L-a-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.2 mg, blueberry anthocyanin 5 mg, gamma-aminobutyric acid 5 mg, L-arginine 5 mg; and the remaining operations are the same, and finally the nutrient composition is obtained.
[0037] Comparative Example 4 The present comparative example is different from Example 1 in that L-arginine is not added to the nutrient composition, i.e., the nutrient composition includes the following amounts by weight of raw materials: L-a-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.2 mg, blueberry anthocyanin 5 mg, gamma-aminobutyric acid 5 mg, L-lysine 5 mg; and the remaining operations are the same, and finally the nutrient composition is obtained.
[0038] Comparative Example 5 The present comparative example is different from Example 1 in that L-a-glycerophosphocholine is not added to the nutrient composition, i.e., the nutrient composition includes the following amounts by weight of raw materials: pyrroloquinoline quinone disodium salt 0.2 mg, blueberry anthocyanin 5 mg, gamma-aminobutyric acid 5 mg, L-lysine 5 mg, L-arginine 5 mg; and the remaining operations are the same, and finally the nutrient composition is obtained.
[0039] Comparative Example 6 The difference between the present comparative example and Example 1 is that no gamma-aminobutyric acid is added in the nutrient composition, i.e. the nutrient composition comprises the following raw materials by weight: L-a-glycerophosphocholine 600 mg, pyrroloquinoline quinone disodium salt 0.2 mg, blueberry anthocyanin 5 mg, L-lysine 5 mg, L-arginine 5 mg; and the rest of the operations are the same, and finally the nutrient composition is obtained.
[0040] In the above Examples 1-6 and Comparative Examples 1-6, in step (3), 300 mL of flavoring adjuvant is added and stirred for 15 min; in step (5), the total volume is adjusted to 1000 mL and the target soluble solid content is 30%, and stirred for 20 min; in step (6), the sterilization temperature of the ultra-high temperature instant sterilization is 125℃, the time is 10 s, and the outlet temperature of the UHT sterilization machine is 30℃; in step (8), the sterilization temperature of the pasteurization is 85℃, and the time is 20 min. Only as a preferred embodiment, in step (3), the flavoring adjuvant can be fruit-flavored adjuvant, or other types of flavoring adjuvant; the fruit-flavored adjuvant can be fruit-flavored concentrate, or fruit juice, essence, etc.; the stirring time can be 10-30 min; in step (5), the target soluble solid content can be 10-50% after adjusting the volume to 1000 mL, and the stirring time can be 10-30 min; in step (6), the sterilization temperature of the ultra-high temperature instant sterilization can be 120-130℃, the time can be 8-15 s, and the outlet temperature of the UHT sterilization machine can be 25-35℃; in step (8), the sterilization temperature of the pasteurization can be 80-90℃, and the stirring time can be 15-25 min. The above parameters can be within the range, and in actual production, adaptive adjustment can be made according to specific conditions.
[0041] In order to verify the effect of the present application, the effects of the nutrient compositions prepared in Examples 1-6 and Comparative Examples 1-8 are detected respectively.
[0042] Comparative Example 7: Tianwang Buxin Pills (concentrated pills, a kind of Chinese patent medicine), Zhongjing Wanxi Pharmaceutical, 0.375 x 200 pills / box.
[0043] Comparative Example 8: Methylphenidate Hydrochloride Tablets (Ritalin, a kind of central nervous stimulant western medicine preparation), Novartis Pharmaceutical, 10 mg / tablet.
[0044] The detection process is as follows: (1) Test experiment: learning and memory scene (university student examination pressure simulation) (2) Subjects: 60 undergraduates in each group, the effect detection is carried out after 4 hours of high-density mathematical test.
[0045] (3) Detection items: ① Working memory: n-back test (3-back difficulty) 2. Long-term memory: GRE vocabulary delayed recall 3. Anxiety level: STAI scale score (4) Detection process: The subjects were administered with the nutrient compositions prepared in Examples 1-6, Comparative Examples 1-6, the Chinese medicine of Comparative Example 7, and the chemical stimulant of Comparative Example 8, respectively, and were detected before administration, 1 hour after administration, and 6 hours after administration. The detection results are shown in Tables 1-3.
[0046] Table 1. Working memory detection results
[0047] Table 2. Long-term memory detection results
[0048] Table 3. Anxiety level detection results
[0049] From Tables 1-3, it can be seen that: The 3-back test accuracy and vocabulary recall amount of Examples 1-6 were all greater than those of Comparative Examples 1-8, and the anxiety score was lower than that of Comparative Examples 1-8, thus it can be known that the nutrient compositions prepared in Examples 1-6 have multiple effects of excellent improvement of cognitive decline symptoms, rapid relief of cognitive fatigue, improvement of thinking agility, and reduction of error rate.
[0050] The 3-back test accuracy and the amount of vocabulary recall of Comparative Examples 1 to 6 are worse than those of Examples 1 to 6, and the anxiety scores are higher than those of Examples 1 to 6, but the 3-back test accuracy and the amount of vocabulary recall of Comparative Examples 1 to 6 are higher than those of Comparative Examples 7 to 8, and the anxiety scores are lower than those of Comparative Examples 7 to 8, that is, the technical effects of the nutrient composition of Comparative Examples 1 to 6 are worse than those of Examples 1 to 6, but are superior to those of Examples 7 to 8. Therefore, it is known that only adding any five of the six components of L-α-glycerophosphocholine, PQQ disodium salt, blueberry anthocyanin, γ-aminobutyric acid, L-lysine, and L-arginine cannot achieve the technical effects of improving cognitive decline symptoms, rapidly relieving cognitive fatigue, improving thinking agility, and reducing error rate, which are produced by adding all of the six components. This is because PQQ disodium salt, blueberry anthocyanin, L-lysine, and L-arginine synergistically promote neural cell energy metabolism; L-α-glycerophosphocholine and γ-aminobutyric acid synergistically regulate neurotransmitter levels, improve cognitive ability, and prevent excessive nerve excitement; PQQ disodium salt and blueberry anthocyanin synergistically provide oxidative protection for neural cells; and the synergistic effect of the above six components forms a three-pathway synergistic mechanism of "neural cell energy metabolism-neurotransmitter balance-oxidative protection", and through multi-target synergistic action, the prepared nutrient composition has multiple effects of improving cognitive decline symptoms, rapidly relieving cognitive fatigue, improving thinking agility, and reducing error rate. The technical effects of improving cognitive decline symptoms, rapidly relieving cognitive fatigue, improving thinking agility, and reducing error rate cannot be achieved by lacking any one of the synergistic effects of the above six components.
[0051] The application also provides the use of the prepared rapid response nutrient composition for cognitive load scenarios of Examples 1 to 6, and the use of the prepared rapid response nutrient composition for cognitive load scenarios of Examples 1 to 6 in the preparation of food for rapidly enhancing cognition.
[0052] In summary, the present application provides a quick-responding nutrient composition for cognitive load scenarios and its preparation method and application: (1) The present application uses L-alpha-glycerophosphocholine, PQQ disodium salt, blueberry anthocyanin, gamma-aminobutyric acid, L-lysine and L-arginine as raw materials to prepare the nutrient composition. PQQ disodium salt, blueberry anthocyanin, L-lysine and L-arginine can promote energy metabolism of nerve cells. L-alpha-glycerophosphocholine and gamma-aminobutyric acid can regulate neurotransmitter levels, improve cognitive ability and prevent excessive excitement of nerves. PQQ disodium salt and blueberry anthocyanin can provide oxidative protection for nerve cells. The synergistic effect of the above six components forms a three-pathway synergistic mechanism of 'energy metabolism of nerve cells-neurotransmitter balance-oxidative protection', and through multi-target synergistic effect, the prepared nutrient composition has multiple effects of improving cognitive decline symptoms, quickly relieving cognitive fatigue, improving thinking agility and reducing error rate, and is especially suitable for high-intensity cognitive load scenarios. (2) The present application selects high bioavailability ingredients as raw materials to improve the absorption and bioavailability of the nutrient composition, and can achieve quick response and good effect of improving cognition. The present application designs the dosage form as a liquid dosage form, which is easy to absorb, has quick effect and is convenient to take. (3) The present application breaks through the three shackles of slow effect, single effect and dependence on stimulants of existing products, and provides a safe, quick and efficient neurotrophic solution for high-intensity cognitive load scenarios. Compared with traditional Chinese medicine compounds, the nutrient composition of the present application is based on the three-pathway synergy of 'energy metabolism of nerve cells-neurotransmitter balance-oxidative protection', and with the aid of the dosage form, it innovatively realizes the order of magnitude improvement in clinical response speed. Compared with the chemical stimulant scheme, the nutrient composition of the present application avoids drug dependence and cardiovascular risk through physiological regulation mechanism, and opens up a new path for the field of cognitive enhancement. The present application is suitable for the instant demand of cognitive enhancement in professional high-intensity mental work scenarios, education and competition fields, special environment operations, neurofunctional rehabilitation assistance, health management upgrade market and the like, and can be widely applied in the field of food processing technology.
[0053] The above-described embodiments are only used to illustrate the technical solutions of the present application, but not limit the same; although the foregoing embodiments of the present application have been described in detail, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement to part of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application, and should be included in the protection scope of the present application.
Claims
1. A fast-acting nutrient composition for use in a cognitive load scenario, characterized in that, The raw materials include the following weight parts: L-α-glycero-phosphocholine 400-600 parts, pyrroloquinoline quinone disodium salt 0.1-0.4 parts, blueberry anthocyanin 4-6 parts, γ-aminobutyric acid 4-6 parts, L-lysine 4-6 parts, and L-arginine 4-6 parts.
2. The rapid response nutrient composition for cognitive load scenarios of claim 1, wherein, The auxiliary materials also include purified water and flavoring auxiliary materials.
3. A method of making a fast-acting nutrient composition for cognitive load scenarios as claimed in claim 2, wherein, The following steps are included: (1) Dissolving L-α-glycero-phosphocholine, pyrroloquinoline quinone disodium salt, and blueberry anthocyanin with purified water as the dissolving solvent to obtain solution A; (2) Dissolving γ-aminobutyric acid, L-lysine, and L-arginine with 50°C purified water, stirring until clear to obtain solution B; (3) Stirring and mixing solution A, solution B, and flavoring auxiliary materials to obtain solution C; (4) Filtering solution C once; (5) Using purified water to set the volume of solution C after the first filtration and stirring to mix well; (6) Ultrahigh-temperature instant sterilization of the solution C after setting the volume; (7) Secondary filtration and filling of solution C after ultrahigh-temperature instant sterilization; (8) Pasteurizing the filled solution C to obtain the nutrient composition.
4. The method of claim 3, wherein the quick response nutrient composition for cognitive load scenarios is prepared by, In step (3), stirring for 10-30 min.
5. The method of claim 3, wherein the quick response nutrient composition for cognitive load scenarios is prepared by, In step (4), using a 200-mesh filter screen for the first filtration.
6. The method of claim 3, wherein the quick response nutrient composition for cognitive load scenarios is prepared by, In step (5), using purified water to set the volume to a target soluble solid content of 10-50%, stirring for 10-30 min.
7. The method of claim 3, wherein the quick response nutrient composition for cognitive load scenarios is prepared by, In step (6), using a UHT sterilizer for ultrahigh-temperature instant sterilization, setting the sterilization temperature to 120-130°C, the time to 8-15 s, and the outlet temperature of the UHT sterilizer to 25-35°C.
8. The method of claim 3, wherein the quick response nutrient composition for cognitive load scenarios is prepared by, In step (7), using a 100-mesh filter screen for the second filtration.
9. The method of claim 3, wherein the quick response nutrient composition for cognitive load scenarios is prepared by, In step (8), the temperature for pasteurization is 80-90°C, and the time is 15-25 min.
10. Use of a fast-responding nutrient composition for cognitive load scenarios as claimed in claim 1 or 2, wherein, A food for preparing rapid cognitive enhancement.