Medicine for treating cerebral thrombosis, cerebral thrombosis precursor and cerebral thrombosis sequelae

Abstract

The invention relates to a medicine for treating cerebral thrombosis, cerebral thrombosis precursor and cerebral thrombosis sequelae. Comprising the following raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 10-20 parts of ligusticum wallichii, 10-20 parts of radix paeoniae rubra, 10-20 parts of gastrodia elata, 2-5 parts of scorpion, 10-20 parts of pseudo-ginseng, 10-20 parts of rhizoma corydalis, 10-20 parts of radix clematidis, 10-20 parts of earthworm, 10-20 parts of honeysuckle stem, 10-20 parts of ginkgo leaf, 1-3 parts of centipede, 10-20 parts of cassia twig, 2-5 parts of leech and 10-20 parts of herba siegesbeckiae. The traditional Chinese medicine is orally taken and externally applied, and has the effects of dispersing blood stasis, relieving spasm, activating blood, relieving pain, tonifying qi and nourishing blood.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, specifically a drug for treating cerebral thrombosis, precursors of cerebral thrombosis, and sequelae of cerebral thrombosis. Background Technology

[0002] Stroke, also known as apoplexy, is mainly caused by factors such as aging and weakened vital energy, internal injuries, excessive emotional stress leading to internal heat and wind, imbalance of the seven emotions, stagnation of liver qi, improper diet leading to phlegm production, excessive consumption of rich and greasy foods leading to spleen dysfunction, failure of qi to transform fluids, accumulation of dampness and phlegm, and phlegm stagnation transforming into heat. These factors lead to an imbalance of yin and yang, disorder of qi and blood, and upward attack on the brain, resulting in sudden collapse, unconsciousness, hemiplegia, and facial paralysis; or, without collapse, only hemiplegia, facial paralysis, slurred speech, and numbness on one side of the body as the main manifestations. It is more common in winter and spring, has a long course, and a poor prognosis.

[0003] Currently, Western medicine treatments often employ medications like Vinpocetine, Doxycycline, or urokinase, primarily for thrombolysis. However, these methods are often ineffective and leave long-term sequelae, leading to a decline in quality of life. Traditional Chinese medicine (TCM) mainly uses formulas such as Buyang Huanwu Decoction, Tianma Gouteng Decoction, and Huatan Tongluo Decoction, but each has its own strengths and weaknesses. Therefore, developing a new TCM drug for treating cerebral thrombosis is of great significance. Summary of the Invention

[0004] The purpose of this invention is to provide a drug for treating cerebral thrombosis, cerebral thrombosis precursors, and cerebral thrombosis sequelae. This drug has a unique formula with synergistic effects among its components, resulting in significant efficacy.

[0005] The technical solution of the present invention:

[0006] A drug for treating cerebral thrombosis, prodromal symptoms of cerebral thrombosis, and sequelae of cerebral thrombosis, characterized in that it comprises the following raw materials in parts by weight: Astragalus membranaceus 15-30 parts, Ligusticum chuanxiong 10-20 parts, Paeonia lactiflora 10-20 parts, Gastrodia elata 10-20 parts, Buthus martensii 2-5 parts, Panax notoginseng 10-20 parts, Corydalis yanhusuo 10-20 parts, Clematis chinensis 10-20 parts, Pheretima aspergillum 10-20 parts, Lonicera japonica vine 10-20 parts, Ginkgo biloba leaf 10-20 parts, Scolopendra subspinipes 1-3 parts, Cinnamomum cassia twig 10-20 parts, Hirudo medicinalis 2-5 parts, and Siegesbeckia orientalis 10-20 parts.

[0007] The beneficial effects of this invention are:

[0008] Stroke has long been the leading cause of death among Chinese residents and is characterized by a high recurrence rate. The nature of stroke is deficiency in origin and excess in superficiality, with deficiency of vital qi as the root cause and phlegm and blood stasis obstructing the collaterals as the superficial manifestation. "Treatise on Febrile Diseases and Miscellaneous Diseases: Treatment of Apoplexy and Arthralgia Syndromes" in "Synopsis of the Golden Chamber" also states, "When wind causes disease, there may be hemiplegia or only paralysis of the arm. This is called bi syndrome. The pulse is faint and rapid, which is caused by wind stroke." Here, "faint pulse" is due to deficiency of vital qi, revealing the pathogenesis of wind stroke with deficiency of vital qi and invasion of pathogenic factors. Qi is the commander of blood. For blood to circulate normally in the vessels, it depends on the control and promotion of qi. When qi is deficient, blood stasis occurs. When blood circulation is impaired, it leads to abnormal water metabolism. Additionally, body fluids belong to yin and cannot be transported without qi. When qi is deficient, dampness and turbidity cannot be transformed, resulting in the formation of phlegm and fluid retention. Phlegm turbidity and blood stasis are both tangible pathogenic factors that interact and combine, blocking the meridians and obstructing qi and blood. When the brain orifices are deprived of nourishment, symptoms such as fainting, aphasia, deviation of the mouth and eyes, and hemiplegia occur, leading to stroke. "Complete Works of Jingyue" states, "Blood cannot circulate without qi, and blood cannot be transformed without qi... Blood is the spirit of qi. Therefore, blood and qi are different in name but of the same kind, and in fact, qi is the master." When qi is deficient, the power to promote blood circulation is weak. When encountering external pathogenic factors, blood vessels become stagnant and form stasis. When qi is deficient, phlegm and dampness are internally generated, blocking the collaterals, affecting blood circulation, and over time, stasis is formed. Stasis transforms into fire, consuming qi and burning body fluids. When qi is deficient, new blood cannot be generated, and the blood vessels become empty, leading to stasis. Blood stasis causes disorders of zang-fu functions. As the disease progresses, qi deficiency worsens.

[0009] This application is taken orally and applied externally, with the efficacy of boosting qi and ascending yang, promoting blood circulation and dredging meridians. It is mainly used for cerebral thrombosis (stroke) and sequelae of cerebral thrombosis, and can be used for dizziness, vertigo, headache, head distension, stiffness of the tongue, slurred speech, numbness of the mouth and tongue, salivation before the onset of the disease, and hemiplegia, hemiparesthesia, hemiparalysis, deviation of the mouth and eyes, slurred speech, choking during eating, diaphragmatic spasm, and neck rigidity after the onset of the disease.

[0010] Astragalus membranaceus, which boosts qi and ascends yang, is the monarch drug.

[0011] Chuanxiong, Red Peony Root, Gastrodia elata, Scorpio, and Panax notoginseng: Chuanxiong treats various pain syndromes caused by blood stasis and qi stagnation, being the qi drug in blood. Red Peony Root clears liver fire and promotes blood circulation to remove stasis. Gastrodia elata is good at calming endogenous wind and stopping convulsions, suppressing hyperactive liver yang. Scorpio has the effects of calming endogenous wind and relieving spasm, dredging collaterals and relieving pain. Panax notoginseng stops bleeding without leaving stasis and promotes blood circulation without consuming qi, serving as the ministerial drugs.

[0012] [[ID=十二]] Corydalis yanhusuo, Clematis chinensis, and Pheretima aspergillum: Corydalis yanhusuo promotes blood circulation, regulates qi, and relieves pain. Clematis chinensis is good at moving upward and outward. Pheretima aspergillum dredges collaterals, together serving as the assistant drugs.

[0013] Lonicera japonica stem, Ginkgo biloba leaf, Scolopendra subspinipes, Cinnamomum cassia twig, Hirudo nipponica, and Siegesbeckia orientalis, promoting blood circulation and dredging meridians, serve as the guiding drugs.

[0014] This formula works synergistically to invigorate Qi and Yang, promote blood circulation, clear the meridians, and dispel wind and phlegm. The medicine applied for here can replenish Qi, nourish blood, promote blood circulation, remove blood stasis, relieve spasms, and alleviate pain, thus better clearing blood vessels. It is used to treat dizziness, lightheadedness, headache, stiff neck, hemiplegia, hemiparesis, facial paralysis, slurred speech, choking while eating, hiccups, etc., with significant efficacy. This medicine not only eliminates the symptoms of pre-stroke (insufficient blood supply to the brain), but also has a significant effect on delaying aging in middle-aged and elderly people. It is highly effective in treating cerebral thrombosis and its sequelae, and also has preventative and health-preserving effects. Detailed Implementation

[0015] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0016] Before further describing specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terminology used in the embodiments of the present invention is for describing specific embodiments and not for limiting the scope of protection of the present invention.

[0017] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in the invention, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0018] It is worth noting that the raw materials used in this invention are all commercially available products, and therefore their sources are not specifically limited.

[0019] In Western medicine, arteriosclerosis is considered the most common and primary cause of cerebral thrombosis. Arteriosclerosis leads to thickening of the endothelium of the arteries, narrowing the lumen. When blood pressure drops or blood flow slows, clotting factors aggregate within the lumen, forming a thrombus. This thrombus results in insufficient blood supply to the brain, causing ischemia and hypoxia, leading to necrosis and other pathological changes. In Traditional Chinese Medicine (TCM), cerebral thrombosis falls under the category of stroke. Its primary pathogenesis is attributed to deficiency of Qi and blood. This deficiency manifests as both Qi and blood deficiency, leading to an imbalance of Yin and Yang in the heart, liver, and kidneys. TCM theory states that the heart governs blood vessels, the liver governs blood, and the kidneys store essence. An imbalance in these three organs results in insufficient essence and blood, slowing blood flow and making it easier for blood clots to form – the TCM concept of "blood stasis." Furthermore, emotional changes, such as excessive anger or grief, can obstruct the flow of Qi and blood, causing pathological changes in the heart, brain, and other organs, ultimately leading to cerebral thrombosis.

[0020] Under the leadership of Song Lingchun, a veteran traditional Chinese medicine doctor at Lingchun Traditional Chinese Medicine Hospital in Lishu County, the inventors, after years of research and development, have adopted new theories and modern Chinese medicine research, combined with the traditional Chinese medicine diagnostic and treatment principles, to effectively treat patients with cerebral thrombosis. This approach achieves the effects of promoting blood circulation, removing blood stasis, relieving spasms, alleviating pain, and restoring normal vascular function. The research involved selecting traditional Chinese medicines such as Astragalus membranaceus, Ligusticum chuanxiong, Paeonia lactiflora, Gastrodia elata, Buthus martensii, Panax notoginseng, Corydalis yanhusuo, Clematis chinensis, Pheretima aspergillum, Lonicera japonica, Ginkgo biloba, Scolopendra subspinipes, Cinnamomum cassia, Hirudo medicinalis, and Siegesbeckia orientalis for modern research, utilizing ancient and modern methods to create advanced formulas. The results include: a) softening coronary arteries; b) clearing blockages in arteriosclerosis; c) relieving spasms in various types of arteriosclerosis, restoring myocardial blood circulation, and treating cerebral thrombosis, its precursors, and sequelae, with an efficacy rate of 92%.

[0021] Astragalus: Sweet and slightly warm in nature, it enters the spleen and lung meridians. Astragalus is sweet and warm, tonifying and ascending, and sweet and bland, promoting diuresis. When used raw, it is slightly warm; when honey-processed, it is warm in nature. It enters the spleen and lung meridians, primarily to support the body's vital energy, and also to eliminate dampness. It is good at tonifying the middle qi and raising clear yang, as well as tonifying lung qi and strengthening the stomach and consolidating the exterior. It treats lung qi deficiency, sinking of middle qi, qi failing to control blood, spontaneous sweating and night sweats, etc. By tonifying qi, it can also generate blood, control blood, generate body fluids, and promote circulation. It treats blood deficiency and chlorosis, metrorrhagia and hematochezia due to qi failing to control blood, thirst due to qi and body fluid deficiency, numbness and pain due to qi deficiency and blood stasis, and hemiplegia, etc.

[0022] Chuanxiong (Ligusticum striatum): Pungent and warm in nature. It enters the liver, gallbladder, and pericardium meridians. Chuanxiong is pungent, aromatic, dispersing, and warming, entering these meridians. It ascends to the head and descends to the blood sea, internally promoting blood circulation and externally dispelling wind and cold. It has a strong blood-activating effect, treating various pains caused by blood stasis and qi stagnation, especially suitable for those with cold symptoms. It was praised by the ancients as "the qi-regulating herb in the blood." It is best for treating various headaches caused by wind-cold and blood stasis; it can also be used for those caused by wind-heat, wind-dampness, and blood deficiency. Therefore, the ancients said, "Headaches are inseparable from Chuanxiong." This product contains alkaloids, volatile oils, phenolic substances, lactones, as well as vitamin A, folic acid, sucrose, sterols, and fatty oils, etc., and has the effects of activating blood circulation, regulating qi, dispelling wind, and relieving pain.

[0023] Red peony root: Bitter and slightly cold in nature. It enters the liver meridian. Red peony root is bitter and dispersing, slightly cold and clearing, specifically entering the liver meridian to clear heat and disperse blood stasis. It clears liver fire and cools the blood, while also promoting blood circulation and removing blood stasis. It combines cooling blood heat, clearing liver fire, and dispersing blood stasis into one, and can be used for all cases of blood heat, blood stasis, and liver fire, whether single or combined, especially suitable for pain caused by blood heat with stasis, blood stasis with heat, or liver fire with stasis. It has the effects of clearing heat and cooling blood, dispersing blood stasis and relieving pain.

[0024] Gastrodia elata: Sweet and neutral in nature, it enters the liver meridian. Gastrodia elata is sweet, mild, and heavy, moistening without being drying, and neutral in nature, specifically targeting the liver. It effectively calms wind and stops spasms, and suppresses liver yang, treating various symptoms of liver yang and liver wind, regardless of whether they are due to cold, heat, deficiency, or excess. It can dispel wind and unblock the meridians, treating numbness and weakness of the limbs and hands and feet. It has the functions of calming wind and stopping spasms, suppressing liver yang, and dispelling wind and unblocking the meridians.

[0025] Whole scorpion: pungent and neutral in nature. Enters the liver meridian. Used for internal wind in the liver, spasms and convulsions, infantile convulsions, stroke with facial paralysis, hemiplegia, tetanus, stubborn rheumatism, and migraine. It has the functions of calming wind and relieving spasms, unblocking meridians and relieving pain, and attacking toxins and dispersing nodules.

[0026] Panax notoginseng: Sweet and slightly bitter in taste, warm in nature, and enters the liver and stomach meridians. Its slightly bitter taste disperses stagnation, while its sweet and warming properties nourish and invigorate. It possesses both penetrating and tonifying properties, entering the liver and stomach meridians. It has strong hemostatic and blood-stasis-removing effects, and can also tonify deficiency. It has the advantage of stopping bleeding without leaving blood stasis and promoting blood circulation without depleting qi. It is effective both internally and externally, and can be used for any bleeding and swelling due to bruising. It is most suitable for those with a cold constitution and deficiency, while those with a hot constitution without deficiency should be combined with heat-clearing and blood-cooling herbs and appropriate other remedies. It mainly contains tetracyclic triterpenoids such as ginsenosides, notoginsenosides, and aesculin, as well as notoginsenosides, quercetin, and polysaccharides. It has the effects of dispersing blood stasis, stopping bleeding, reducing swelling, and relieving pain.

[0027] Corydalis: Corydalis enters the liver, spleen and heart meridians. It can invigorate blood, promote qi circulation and relieve pain. When combined with Salvia miltiorrhiza, Corydalis can enhance the effects of promoting qi circulation and relieving pain, effectively improving chest pain, chest tightness, chest pain, angina pectoris, coronary heart disease and other conditions caused by qi stagnation and blood stasis.

[0028] Clematis chinensis: Pungent, salty, and warm in nature. It enters the Bladder Meridian. Clematis chinensis is pungent, salty, soft, and warm, entering the Bladder Meridian (or some say the twelve meridians). It has a strong and rapid effect, effectively dispelling wind and dampness, clearing the meridians, and also eliminating phlegm or softening hard masses. It is most suitable for rheumatic pain, contractures, numbness, and difficulty in flexion and extension accompanied by cold, and also treats phlegm accumulation. Ancient texts say it can "soften bones," and it is good for treating fishbone stuck in the throat. It is often decocted with sugar and vinegar. Clematis chinensis contains protoolenic acid, hederaponin, protoanemonin, palmitic acid, and other components. It has the effects of dispelling wind and dampness and clearing the meridians.

[0029] Earthworm: Salty and cold in nature, it enters the liver, spleen, and bladder meridians. This herb is salty and cold, clearing and draining, and has a purging and unblocking effect. Entering the liver meridian, it can clear heat, calm wind, and stop spasms; entering the lung meridian, it can clear lung heat and relieve asthma; entering the bladder meridian, it can promote urination and relieve constipation; it travels through the meridians, unblocking the channels and treating arthralgia. It has the effects of clearing heat and calming convulsions, unblocking the channels, relieving asthma, and promoting urination. It is often used for high fever with delirium, convulsions, joint pain, numbness of limbs, hemiplegia, lung heat with cough and asthma, edema with oliguria. Modern research shows that earthworm mainly contains earthworm antipyretic alkaloids, earthworm toxins, 6-hydroxypurine, xanthine, adenine, guanine, choline, etc.; it also contains various amino acids and fatty acids. Earthworm has pharmacological effects such as antipyretic, sedative, anticonvulsant, antithrombotic, antihypertensive, anti-inflammatory, analgesic, antiasthmatic, and immune-enhancing effects.

[0030] Honeysuckle vine: Sweet in taste and cold in nature, it enters the lung and stomach meridians. Honeysuckle vine has the effects of clearing heat and detoxifying, dispelling wind and unblocking the meridians. It is mainly used for febrile diseases, dysentery due to heat toxicity, carbuncles and sores, rheumatic arthralgia, and red, swollen, hot, and painful joints. It mainly contains organic acids such as chlorogenic acid and isochlorogenic acid, flavonoids such as quercetin and luteolin, and saponins such as honeysuckle glycoside A.

[0031] Ginkgo leaves: Ginkgo leaves can dilate blood vessels, improve blood supply, and relieve vascular spasms, thereby alleviating pain symptoms. Ligusticum striatum can promote blood circulation, enhance blood vessel elasticity, and relieve vascular spasms, helping to improve problems such as poor blood circulation and meridian blockage. Together with cloves, long pepper, and costus root, they can relieve vascular spasms.

[0032] Centipede: pungent and warm in nature. It enters the liver meridian. It has the functions of calming wind and relieving spasms, unblocking meridians and relieving pain, and attacking toxins and dissipating nodules. It is used for internal liver wind, spasms and convulsions, infantile convulsions, stroke with facial paralysis, hemiplegia, tetanus, stubborn rheumatism, migraine, sores, scrofula, and snake and insect bites.

[0033] Cinnamon twig: Cinnamon twig is pungent, sweet, and warm, and enters the heart, lung, and bladder meridians. It has the functions of inducing sweating to relieve exterior syndromes, warming the meridians and promoting yang, dispelling cold and relieving pain, and assisting yang and transforming qi. First, it can be used for wind-cold exterior syndromes, which are symptoms of fever, chills, and sweating. Second, it can also be used for palpitations and chest pain. It can warm the meridians and promote heart yang, unblock the collaterals, and relieve pain. Third, because it enters the bladder meridian, it has the functions of assisting yang and transforming qi and promoting diuresis. Fourth, it has the function of dispelling cold and relieving pain, and is used for dysmenorrhea and joint pain.

[0034] Leech: Salty, bitter, and neutral in nature. It enters the liver meridian. It breaks up blood stasis, promotes menstruation, removes blood stasis, and eliminates masses. It is used for amenorrhea due to blood stasis, abdominal masses, hemiplegia due to stroke, and injuries from falls.

[0035] Siegesbeckia orientalis: Pungent, bitter, and cold in nature. It enters the liver and kidney meridians. Its bitter and drying properties, along with its cold nature, clear and resolve ailments. Entering the liver and kidney meridians, its medicinal power is mild. It dispels wind-dampness, unblocks meridians, clears heat and detoxifies, and lowers blood pressure. When used raw, its cold nature and clearing power are strong; when processed, its cold nature is reduced and its clearing power is moderate. It effectively dispels wind-dampness between muscles and bones and unblocks meridians, treating numbness and pain in the limbs, stroke-induced hemiplegia, or weakness in the legs. It is suitable for both hot and cold conditions, but is best for those with heat-related conditions or high blood pressure. For those with heat-related conditions, it should be used raw; for those with cold-related conditions, it should be processed. When used raw, it also clears heat and toxins, and is suitable for treating sores, boils, carbuncles, eczema, and itching. In addition, it can be used to treat hypertension and numbness in the limbs. It mainly contains siegesethrol and alkaloids. It has the effects of dispelling wind and dampness, clearing the meridians, clearing heat and detoxifying, and lowering blood pressure. It is often used for rheumatic pain, weakness of muscles and bones, soreness of the waist and knees, numbness of the limbs, hemiplegia, and rashes and eczema.

[0036] Example 1

[0037] A drug for treating cerebral thrombosis, prodromal symptoms of cerebral thrombosis, and sequelae of cerebral thrombosis comprises the following raw materials in parts by weight: Astragalus membranaceus 20 parts, Ligusticum chuanxiong 15 parts, Paeonia lactiflora 15 parts, Gastrodia elata 15 parts, Buthus martensii 3 parts, Panax notoginseng 15 parts, Corydalis yanhusuo 15 parts, Clematis chinensis 15 parts, Pheretima aspergillum 15 parts, Lonicera japonica vine 15 parts, Ginkgo biloba leaf 15 parts, Scolopendra subspinipes 2 parts, Cinnamomum cassia twig 15 parts, Hirudo medicinalis 4 parts, and Siegesbeckia orientalis 15 parts. The preparation method is as follows: the above raw materials are pulverized to 200 mesh, sterilized at 100-110 degrees Celsius, cooled, and all the drugs are mixed to obtain a powder, which is then encapsulated, with each capsule containing 0.5 grams.

[0038] Example 2

[0039] A drug for treating cerebral thrombosis, prodromal symptoms of cerebral thrombosis, and sequelae of cerebral thrombosis comprises the following raw materials in parts by weight: Astragalus membranaceus 15 parts, Ligusticum chuanxiong 10 parts, Paeonia lactiflora 10 parts, Gastrodia elata 10 parts, Buthus martensii 2 parts, Panax notoginseng 10 parts, Corydalis yanhusuo 10 parts, Clematis chinensis 10 parts, Pheretima aspergillum 10 parts, Lonicera japonica vine 10 parts, Ginkgo biloba leaf 10 parts, Scolopendra subspinipes 1 part, Cinnamomum cassia twig 10 parts, Hirudo medicinalis 2 parts, and Siegesbeckia orientalis 10 parts. The preparation method is as follows: the above raw materials are pulverized to 200 mesh, sterilized at 100-110 degrees Celsius, cooled, and all the drugs are mixed to obtain a powder, which is then encapsulated, with each capsule containing 0.5 grams.

[0040] Example 3

[0041] A drug for treating cerebral thrombosis, prodromal symptoms of cerebral thrombosis, and sequelae of cerebral thrombosis comprises the following raw materials in parts by weight: Astragalus membranaceus 30 parts, Ligusticum chuanxiong 20 parts, Paeonia lactiflora 20 parts, Gastrodia elata 20 parts, Buthus martensii 5 parts, Panax notoginseng 20 parts, Corydalis yanhusuo 20 parts, Clematis chinensis 20 parts, Pheretima aspergillum 20 parts, Lonicera japonica vine 20 parts, Ginkgo biloba leaf 20 parts, Scolopendra subspinipes 3 parts, Cinnamomum cassia twig 20 parts, Hirudo medicinalis 5 parts, and Siegesbeckia orientalis 20 parts. The preparation method is as follows: the above raw materials are pulverized to 200 mesh, sterilized at 100-110 degrees Celsius, cooled, and all the drugs are mixed to obtain a powder, which is then encapsulated, with each capsule containing 0.5 grams.

[0042] Example 4 Clinical Study

[0043] Clinical analysis data of the traditional Chinese medicine composition in Example 1 of this invention were collected from 100 patients with coronary heart disease from Lishu Lingchun Traditional Chinese Medicine Hospital (formerly known as Lishu Huichun Traditional Chinese Medicine Hospital). These patients were randomly divided into a treatment group and a control group at a 1:1 ratio. The treatment group consisted of 50 patients with an average age of approximately 63 years, and the control group consisted of 50 patients with an average age of approximately 62 years. There were no significant differences between the two groups in terms of age, gender, or disease duration. The patients included those with pre-thrombotic symptoms, thrombotic symptoms, and sequelae of thrombotic events.

[0044] Diagnostic criteria:

[0045] Western medicine diagnostic criteria: Western medicine diagnosis meets the "Diagnostic Points for Various Cerebrovascular Diseases", with paralysis of one side of the limbs, confirmed by imaging examinations such as MRI or CT as cerebral infarction or cerebral hemorrhage, and with obvious sequelae of limb motor dysfunction.

[0046] Traditional Chinese Medicine diagnostic criteria: (1) The TCM diagnostic criteria for stroke are in accordance with the "Standards for Diagnosis and Evaluation of Efficacy of Stroke". (2) The diagnostic criteria for stroke symptoms are in accordance with the "Standards for Differentiation and Diagnosis of Stroke" drafted and formulated by the Brain Disease Emergency Research Collaboration Group of the State Administration of Traditional Chinese Medicine in 1994.

[0047] Treatment methods:

[0048] The control group was given Buyang Huanwu Decoction, decocted in water and taken orally, with 14 days constituting one course of treatment.

[0049] The treatment group was given the drug formulation of Example 1 of this application, 2.5g each time, twice a day, for 14 days as one course of treatment. At the same time, they were given massage once a day (massaging the tender points of the head, shoulder blades, hands, elbows, hips, knees and ankles). After the massage, the drug formulation of Example 1 of this application was mixed with petroleum jelly to form a paste and applied externally to the massage tender points once a day.

[0050] Efficacy evaluation criteria

[0051] According to the "Diagnostic and Efficacy Evaluation Criteria for Stroke", the diagnostic criteria for this disease are as follows:

[0052] ①Divine Consciousness

[0053] Normal: 0 points; Drowsiness: 3 points; Confusion: 5 points; Stunned: 7 points; Lethargic: 9 points;

[0054] ②Language

[0055] Normal: 0 points; Unclear articulation: 1 point; Incomplete sentences: 3 points; Unclear vocabulary: 4 points; Aphasia: 6 points;

[0056] ③ Facial paralysis

[0057] None: 0 points; Mild paralysis: 1 point; Total paralysis: 2 points;

[0058] ④ Eye signs

[0059] None: 0 points; Upward-pointing eyes: 2 points; Eyes not blinking: 4 points;

[0060] ⑤ Upper limb paralysis

[0061] None: 0 points; Weak lifting strength: 1 point; Lifting above shoulder: 2 points; Lifting below shoulder, can only swing slightly at most: 4 points; Cannot move: 6 points

[0062] ⑥ Finger paralysis

[0063] None: 0 points; Weak: 1 point; Incomplete fist clenching and finger extension: 2 points; Slight movement: 4 points; Complete paralysis: 5 points;

[0064] ⑦ Lower limb paralysis

[0065] None: 0 points; Raised more than 45°: 1 point; Raised less than 45°: 2 points; Swinging and translating: 4 points; Slight movement or no movement: 6 points;

[0066] ⑧ Toe paralysis

[0067] None: 0 points; Weakness: 1 point; Incomplete flexion and extension: 2 points; Slight movement: 4 points; Complete paralysis: 5 points;

[0068] ⑨ Other symptoms

[0069] Abnormal pupils: 7 points; Convulsions: 7 points; Vomiting blood and bloody stools: 8 points; Incontinence of urine and feces: 8 points; Eyes closed and mouth open: 8 points; Snoring and weak breathing: 9 points; Weak and almost imperceptible pulse: 9 points; Cold hands and limbs: 9 points;

[0070] Scoring: The disease diagnosis score is the sum of the highest scores of each item, with a maximum score of 52 points.

[0071] Diagnostic grading: 1-13 points are mild; 14-26 points are moderate; 27-39 points are severe; and 40 points or above are extremely severe.

[0072] Efficacy assessment: The percentage conversion between pre-treatment and post-treatment scores is calculated as follows: [(pre-treatment score - post-treatment score) / pre-treatment score] × 100%, expressed as a percentage.

[0073] (1) Complete recovery (basic recovery): ≥81%;

[0074] (2) Significant effect (significant improvement): 56%-80%;

[0075] (3) Effective (improvement and slight improvement): 11%-55%;

[0076] (4) Invalid (no change): <11%.

[0077] Overall effective rate = (number of cured cases + number of cases with significant improvement + number of cases with improvement) / total number of cases × 100%.

[0078] Cure rate = (Number of cured cases / Total number of cases) × 100%.

[0079] Experimental treatment results: Evaluation of the effects between the treatment group and the control group

[0080] Group Number of examples get well Effective efficient invalid Overall effectiveness % Treatment group 50 cases 40 cases 4 cases 2 cases 4 cases 92％ control group 50 cases 35 cases 6 cases 2 cases 7 cases 85％

[0081] Experimental conclusion:

[0082] Stroke and its sequelae fall under the category of "dizziness" in Traditional Chinese Medicine (TCM). TCM theory holds that the kidneys govern bones, produce marrow, and connect to the brain. The kidneys contain true yin and true yang, and store essence. The *Neijing* (Inner Canon of Medicine) refers to the brain as the "sea of ​​marrow," meaning it is the place where marrow gathers, not the place where it is produced. Ultimately, it originates from the combination of true yin and true yang qi within the kidneys. The essence of the kidneys ascends along the Du meridian and flows into the brain, replenishing the sea of ​​marrow. In the elderly, kidney deficiency, prolonged illness affecting the kidneys, or excessive sexual activity damaging the kidneys lead to depletion of kidney essence, preventing the production of marrow. Since the brain is the sea of ​​marrow, insufficient marrow in this area results in dizziness. Therefore, kidney deficiency, qi deficiency, blood stasis, and phlegm turbidity are the main causes and mechanisms of the disease. Treatment should focus on tonifying qi and raising yang, promoting blood circulation and unblocking the meridians. Buyang Huanwu Decoction primarily promotes blood circulation, tonifies qi, and nourishes blood, but its effect on removing blood stasis is poor. It cannot relieve spasms, stop pain, or clear blood vessels. The medicine described in this application, however, can tonify qi, nourish blood, promote blood circulation, remove blood stasis, relieve spasms, stop pain, and better clear blood vessels.

[0083] Specific case:

[0084] Case 1

[0085] Mr. Wang, male, 76 years old, from Jinshan Township, Lishu County, came to our hospital in January 2023. The patient reported dizziness, headache, which worsened with exertion, numbness of the mouth and tongue, heaviness and sluggishness in the limbs, poor appetite and sleep, dry stools, red tongue with a thin white coating, and a wiry and rapid pulse. He was diagnosed with a precursor to cerebral thrombosis. Dr. Song prescribed the formula medicine of Example 2 of this application (Astragalus membranaceus 15g, Ligusticum chuanxiong 10g, Paeonia lactiflora 10g, Gastrodia elata 10g, Buthus martensii 2g, Panax notoginseng 10g, Corydalis yanhusuo 10g, Clematis chinensis 10g, Pheretima aspergillum 10g, Lonicera japonica vine 10g, Ginkgo biloba leaf 10g, Scolopendra subspinipes 1g, Cinnamomum cassia twig 10g, Hirudo medicinalis 2g, Siegesbeckia orientalis 10g), 2.5g orally, twice a day. Simultaneously, daily massage (massaging the tender points of the head, shoulder blades, hands, elbows, hips, knees, and ankles) was performed. After the massage, the medicine formulated in Example 2 of this application was mixed with petroleum jelly to form a paste and applied externally to the massaged tender points once daily. After three days of medication, limb movement and speech symptoms improved. After 14 days of treatment, dizziness and tongue numbness symptoms basically disappeared, and the patient was discharged. After discharge, the patient continued medication for 14 days, recovered completely, and returned to normal life. A follow-up visit six months later showed no recurrence.

[0086] Case 2

[0087] Ms. Zhang, female, 63 years old, from Tiedong District, Siping City, came to our hospital in March 2023. Her family reported: left-sided hemiplegia, facial paralysis, slurred speech, choking when drinking, significant crying and laughing, bedridden, pale tongue with a thick, greasy coating, and a wiry, slippery pulse. Physical examination revealed: blood pressure 160 / 100 mmHg, tongue deviated to the left, left-sided limb muscle strength grade [missing information]. She was diagnosed with cerebral infarction. Dr. Song prescribed the formula from Example 3 of this application (Astragalus membranaceus 30 parts, Ligusticum chuanxiong 20 parts, Paeonia lactiflora 20 parts, Gastrodia elata 20 parts, Buthus martensii 5 parts, Panax notoginseng 20 parts, Corydalis yanhusuo 20 parts, Clematis chinensis 20 parts, Pheretima aspergillum 20 parts, Lonicera japonica 20 parts, Ginkgo biloba 20 parts, Scolopendra subspinipes 3 parts, Cinnamomum cassia 20 parts, Hirudo medicinalis 5 parts, Siegesbeckia orientalis 20 parts), orally, 2.5g each time, twice a day. Simultaneously, daily massage (massaging the tender points of the head, shoulder blades, hands, elbows, hips, knees, and ankles) was performed. After the massage, the medicine formulated in Example 3 of this application was mixed with petroleum jelly to form a paste and applied externally to the massaged tender points once daily. After three days of medication, limb movement and speech symptoms improved. After 14 days of treatment, symptoms of facial paralysis, left-sided limb weakness, and slurred speech significantly improved, and the patient was discharged. The patient continued medication for one month after discharge and recovered completely, returning to a normal life. A follow-up visit six months later showed no recurrence.

[0088] Case 3

[0089] Mr. Deng, male, 66 years old, from Quanyanling Township, Lishu County, came to our hospital in April 2023. He reported post-stroke sequelae, hemiplegia, slurred speech, and inability to eat normally. He had a history of hypertension prior to the illness. After the onset of the illness, he received comprehensive Western medicine treatment at Lishu County Hospital, which improved his condition somewhat, but his slurred speech, hemiplegia, and difficulty walking remained, so he was discharged. Upon arrival at our hospital, his symptoms included: right hemiplegia, slurred speech, choking when drinking, occasional dizziness, headache, worsening with exertion, irritability, and insomnia. The patient presented with a red tongue, thin coating, and a wiry, rapid pulse. Dr. Song prescribed the formula from Example 1 of this application (Astragalus membranaceus 20g, Ligusticum chuanxiong 15g, Paeonia lactiflora 15g, Gastrodia elata 15g, Buthus martensii 3g, Panax notoginseng 15g, Corydalis yanhusuo 15g, Clematis chinensis 15g, Pheretima aspergillum 15g, Lonicera japonica vine 15g, Ginkgo biloba leaf 15g, Scolopendra subspinipes 2g, Cinnamomum cassia twig 15g, Hirudo medicinalis 4g, Siegesbeckia orientalis 15g), orally, 2.5g each time, twice a day. Simultaneously, daily massage was performed (massaging the tender points of the head, shoulder blades, hands, elbows, hips, knees, and ankles). After the massage, the formula from Example 1 was mixed with Vaseline oil to form a paste and applied externally to the massaged tender points, once daily. After three days of medication, the patient's motor and speech symptoms improved. After 14 days of treatment, the symptoms significantly improved; speech became clear, although the speech rate was slow. The numbness on the affected side improved. The patient remained hospitalized until one month later and was discharged. After being discharged from the hospital, the patient continued medication for two months and basically recovered, able to take care of themselves. A follow-up visit six months later showed continued good recovery.

[0090] Case 4

[0091] Ms. Wang, female, 58 years old, from Xiaochengzi Town, Lishu County, came to our hospital in March 2020. She reported dizziness, a heavy feeling in her head, occasional nausea, chest tightness, numbness in her right limbs, numbness in her mouth and tongue, obesity, excessive sleepiness and vivid dreams, a large, pale tongue with a thick, greasy coating, and a deep, slippery pulse. She was diagnosed with a precursor to cerebral thrombosis. Dr. Song prescribed the formula from Example 2 of this application (Astragalus membranaceus 15g, Ligusticum chuanxiong 10g, Paeonia lactiflora 10g, Gastrodia elata 10g, Buthus martensii 2g, Panax notoginseng 10g, Corydalis yanhusuo 10g, Clematis chinensis 10g, Pheretima aspergillum 10g, Lonicera japonica vine 10g, Ginkgo biloba leaf 10g, Scolopendra subspinipes 1g, Cinnamomum cassia twig 10g, Hirudo medicinalis 2g, Siegesbeckia orientalis 10g), orally, 2.5g each time, twice a day. Simultaneously, daily massage (massaging the tender points of the head, shoulder blades, hands, elbows, hips, knees, and ankles) was performed. After the massage, the medicine formulated in Example 3 of this application was mixed with petroleum jelly to form a paste and applied externally to the massaged tender points once daily. After three days of medication, limb movement and speech symptoms improved. After 14 days of treatment, symptoms such as weakness in the arms and legs, dizziness, and numbness of the lips disappeared, and the patient was discharged. The patient continued medication for 14 days after discharge, and their life returned to normal. Follow-up visits six months and one year later showed no recurrence.

[0092] Case 5

[0093] Ms. Li, female, 62 years old, from Shuanghe Township, Lishu County, came to our hospital in May 2021. She reported mild facial paralysis, unilateral leg paralysis, drooling, pale tongue with a white coating, and a deep pulse. She was diagnosed with cerebral thrombosis. Dr. Song prescribed the formula from Example 2 of this application (Astragalus membranaceus 15g, Ligusticum chuanxiong 10g, Paeonia lactiflora 10g, Gastrodia elata 10g, Buthus martensii 2g, Panax notoginseng 10g, Corydalis yanhusuo 10g, Clematis chinensis 10g, Pheretima aspergillum 10g, Lonicera japonica vine 10g, Ginkgo biloba leaf 10g, Scolopendra subspinipes 1g, Cinnamomum cassia twig 10g, Hirudo medicinalis 2g, Siegesbeckia orientalis 10g), orally, 2.5g each time, twice a day. Simultaneously, she received daily massage (massaging the tender points of the head, shoulders, hands, elbows, hips, knees, and ankles). After the massage, the formula from Example 2 of this application was mixed with Vaseline oil to form a paste and applied externally to the massaged tender points once daily. Three days after taking the medication, the patient's limb movement and speech symptoms improved. After 14 days of treatment, the facial paralysis, leg movement, and drooling significantly improved, and the patient was discharged. After discharge, the patient continued medication for another 14 days, recovered completely, and returned to a normal life. A follow-up visit one year later showed a normal life with no recurrence.

[0094] Case 6

[0095] Mr. Wang, male, 71 years old, from Tiexi District, Siping City, came to our hospital in April 2022. He reported sequelae of cerebral thrombosis, including motor disorders, hemiplegia, abnormalities on one side of his limbs and face, difficulty speaking, low mood, and depression. He received comprehensive Western medicine treatment at Siping Central Hospital, along with traditional Chinese medicine for 14 days. After treatment, his condition improved to some extent, and he was discharged. Later, through a referral, he came to our hospital. Dr. Song prescribed the formula from Example 1 of this application (Astragalus membranaceus 20g, Ligusticum chuanxiong 15g, Paeonia lactiflora 15g, Gastrodia elata 15g, Buthus martensii 3g, Panax notoginseng 15g, Corydalis yanhusuo 15g, Clematis chinensis 15g, Pheretima aspergillum 15g, Lonicera japonica vine 15g, Ginkgo biloba leaf 15g, Scolopendra subspinipes 2g, Cinnamomum cassia twig 15g, Hirudo medicinalis 4g, Siegesbeckia orientalis 15g), orally, 2.5g each time, twice a day. Simultaneously, daily massage (massaging the tender points of the head, shoulder blades, hands, elbows, hips, knees, and ankles) was performed. After the massage, the medicine formulated in Example 1 of this application was mixed with petroleum jelly to form a paste and applied externally to the massaged tender points once daily. Symptoms improved after 14 days of hospital treatment, and after a month of continuous hospitalization, symptoms significantly improved, and the patient was discharged. After three months of continued medication after discharge, the patient was basically able to take care of themselves. A follow-up visit six months later showed excellent recovery.

[0096] In the process of researching and developing this traditional Chinese medicine preparation, the present invention conducted a large number of experiments on the selection and proportion of raw materials in the formulation, and successfully invented the above-mentioned formulation and preparation process. The weight ratio is very important, as the amount of each component will have a certain impact on the overall therapeutic effect. In addition, the process flow also has a certain impact on the efficacy and quality stability of the medicine.

Claims

1. A medicament for treating cerebral thrombosis, cerebral thrombosis precursors and cerebral thrombosis sequelae, characterized by: It comprises the following raw materials by weight: Huangqi 15-30 parts, Chuanqiong 10-20 parts, Chishao 10-20 parts, Tianma 10-20 parts, Quanzhong 2-5 parts, Sanqi 10-20 parts, Yuanhu 10-20 parts, Weilingxian 10-20 parts, Dilong 10-20 parts, Rongfengteng 10-20 parts, Yinxingye 10-20 parts, Wugong 1-3 parts, Guizhi 10-20 parts, Shuizhi 2-5 parts, Hishengcao 10-20 parts. ​ 2. The drug for treating cerebral thrombosis, cerebral thrombosis precursor and cerebral thrombosis sequelae according to claim 1, characterized in that: It comprises the following raw materials by weight: Huangqi 20 parts, Chuanqiong 15 parts, Chishao 15 parts, Tianma 15 parts, Quanzhong 3 parts, Sanqi 15 parts, Yuanhu 15 parts, Weilingxian 15 parts, Dilong 15 parts, Rongfengteng 15 parts, Yinxingye 15 parts, Wugong 2 parts, Guizhi 15 parts, Shuizhi 4 parts, Hishengcao 15 parts.

3. The use of a drug for treating cerebral thrombosis, cerebral thrombosis precursors and cerebral thrombosis sequelae according to claim 1 in treating cerebral thrombosis.

4. The drug for treating cerebral thrombosis, cerebral thrombosis precursor and cerebral thrombosis sequelae according to claim 1, characterized in that: the drug is a drug for treating cerebral thrombosis, cerebral thrombosis precursor and cerebral thrombosis sequelae, which comprises the compound of claim 1. The drug is prepared as follows: the above raw materials are ground to 200 mesh, and then subjected to sterilization and aging at 100-110 DEG C. After cooling, all the drugs are mixed to prepare a powder, which is then filled into capsules, each containing 0.5 g.