Composition for improving immunity and delaying senescence and preparation method thereof

Abstract

The invention discloses a composition for improving immunity and delaying senescence and a preparation method thereof. Belongs to the technical field of functional health. The composition comprises the following components in parts by mass: 5-50 parts of collagen, 10-80 parts of paeonia ostii tea, 1-20 parts of an antioxidant, 3-10 parts of an intestinal microecology regulator and 1-3 parts of an energy metabolism and nerve regulator. According to the invention, through multi-system cooperation and multi-target intervention, dual effects of immune enhancement and senescence delay are realized. Through scientific compounding and a special process, the product has the advantages of stable components, uniform activity and good solubility. Animal experiments and theoretical models show that immune organs can be effectively protected, accumulation of aging markers is reduced, and a solution is provided for development of comprehensive anti-aging health products.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of functional health care, more particularly to a composition for improving immunity and delaying aging and a preparation method thereof. BACKGROUND

[0002] In recent years, with the improvement of people's living standards and the enhancement of health consciousness, the demand for nutritional products with the functions of enhancing immunity and delaying aging is increasing. Immunity is an important physiological function of the human body to resist the invasion of external pathogens and maintain the stability of the internal environment, while aging is a physiological process that organisms inevitably experience in their life cycle, often accompanied by phenomena such as decline in body function, slowing down of metabolism, and skin aging. Therefore, it is of great application value and market prospect to develop a functional composition that can both enhance the immunity of the body and delay the aging process.

[0003] However, the existing products still have the following defects: ① The existing products are mostly simple superposition, lacking a scientific compounding system based on multi-target and multi-pathway synergistic action. Such single-dimensional intervention strategy leads to limited product effect and difficulty in meeting the needs of consumers for comprehensive health improvement. ② The product ingredients are mostly vitamin C, vitamin E, grape seed extract, collagen peptide, etc., lacking the development of emerging functional ingredients. ③ Although the solid beverage dosage form is convenient to use, how to solve the problems of uneven mixing, poor taste, poor stability of reconstitution, and how to ensure the stability of functional ingredients during the shelf life, are still technical difficulties.

[0004] Therefore, how to realize the dual functions of immune regulation and aging delay, while taking into account the safety and stability of the product, is a technical problem to be solved by those skilled in the art. SUMMARY

[0005] Therefore, the present application provides a composition for improving immunity and delaying aging and a preparation method thereof.

[0006] In order to solve the above technical problems, the present application adopts the following technical solutions: A composition for improving immunity and delaying aging, comprising the following components in mass fraction: collagen 5-50 parts, Danfeng Mudan tea 10-80 parts, antioxidant 1-20 parts, intestinal microecological regulator 3-10 parts, and energy metabolism and nerve regulator 1-3 parts.

[0007] Further, The collagen is one or both of bone collagen peptide and fish collagen tripeptide; The Danfeng peony tea comprises jujube, Danfeng peony flower, dried ginger, malt, licorice, orange peel, high-quality ginger, daye flower, baizhi, cassia, double-petaled red rose, brown sugar, malt dextrin, wheat oligopeptide, and corn oligopeptide powder; The antioxidant is one or more of grape seed extract, epigallocatechin gallate, chrysanthemum powder, nicotinamide, sea buckthorn powder, phyllanthus emblica fruit powder, and snow lotus culture; The intestinal microecological regulator is one or more of isomaltooligosaccharide, xylooligosaccharide, inulin, small molecule citrus pectin, chitooligosaccharide, yam powder, yiyi ren powder, gualou powder, white mung bean powder, and winter melon kernel powder; The energy metabolism and nerve regulator is one or more of 2-oxoglutaric acid, pyrroloquinoline quinone disodium salt, auricularia auricula concentrate powder, gamma-aminobutyric acid, spina date seed powder, poria cocos powder, baizhi powder, earthworm protein, and vitamin D3.

[0008] The beneficial effects achieved are that the composition improves immunity and delays aging by constructing a multi-target, multi-level synergistic network. The Danfeng peony tea and antioxidant components such as grape seed extract and EGCG synergistically reduce oxidative stress, thereby protecting immune cells and delaying cell aging. The intestinal microecological regulator promotes the proliferation of beneficial bacteria and improves the intestinal barrier function. The collagen peptide provides repair materials for the skin and connective tissue, and its active peptide segment can also participate in immune regulation. The energy metabolism regulator represented by 2-oxoglutaric acid and PQQ provides energy for immune cells and activates intrinsic anti-aging mechanisms such as autophagy. In addition, the nerve-regulating components such as gamma-aminobutyric acid, spina date seed, and vitamin D3 act on the neuroendocrine-immune network, relieving stress-induced immune suppression. The components support and synergize with each other.

[0009] Further, a flavoring agent is further included.

[0010] Further, the components include the following mass fractions: bone collagen peptide 10-25 parts, fish collagen tripeptide 3-10 parts, jujube 2-8 parts, Danfeng peony flower 1-5 parts, dried ginger 0.5-3 parts, malt 1-5 parts, licorice 0.5-3 parts, orange peel 1-4 parts, high-quality ginger 0.2-1.5 parts, Daye flower 0.5-2 parts, Baizhi 0.2-1.5 parts, cassia 0.2-1.5 parts, double-petaled red rose 1-4 parts, brown sugar 5-15 parts, malt dextrin 20-50 parts, wheat oligopeptide 2-8 parts, corn oligopeptide powder 1-5 parts, grape seed extract 1-5 parts, epigallocatechin gallate 0.1-2 parts, chrysanthemum powder 0.5-3 parts, nicotinamide 0.05-0.3 parts, sea buckthorn powder 1-4 parts, phyllanthus emblica fruit powder 0.5-3 parts, saussurea culture 0.1-1 parts, isomalto-oligosaccharide 3-10 parts, xylo-oligosaccharide 1-5 parts, inulin 5-15 parts, small molecule citrus pectin 1-4 parts, chitooligosaccharide 0.5-3 parts, yam powder 2-8 parts, coix seed powder 2-8 parts, pueraria powder 1-5 parts, white kidney bean powder 1-4 parts, winter melon seed powder 0.5-3 parts, 2-oxoglutaric acid 0.5-3 parts, pyrroloquinoline quinone disodium salt 0.01-0.1 parts, tricholoma matsutake concentrated powder 0.5-3 parts, gamma-aminobutyric acid 0.1-0.5 parts, spina date seed powder 1-5 parts, poria cocos powder 1-5 parts, Baizhi powder 0.2-1.5 parts, earthworm protein 0.5-3 parts, vitamin D3 0.0001-0.001 parts, steviol glycoside 0.1-1 parts.

[0011] Further, the components include the following mass fractions: bone collagen peptide 10-25 parts, fish collagen tripeptide 3-10 parts, jujube 2-8 parts, Danfeng peony flower 1-5 parts, dried ginger 0.5-3 parts, malt 1-5 parts, licorice 0.5-3 parts, orange peel 1-4 parts, high-quality ginger 0.2-1.5 parts, Daye flower 0.5-2 parts, Baizhi 0.2-1.5 parts, cassia 0.2-1.5 parts, double-petaled red rose 1-4 parts, brown sugar 5-15 parts, malt dextrin 20-50 parts, wheat oligopeptide 2-8 parts, corn oligopeptide powder 1-5 parts, grape seed extract 1-5 parts, epigallocatechin gallate 0.1-2 parts, chrysanthemum powder 0.5-3 parts, nicotinamide 0.05-0.3 parts, sea buckthorn powder 1-4 parts, phyllanthus emblica fruit powder 0.5-3 parts, saussurea culture 0.1-1 parts, isomalto-oligosaccharide 3-10 parts, xylo-oligosaccharide 1-5 parts, inulin 5-15 parts, small molecule citrus pectin 1-4 parts, chitooligosaccharide 0.5-3 parts, yam powder 2-8 parts, coix seed powder 2-8 parts, pueraria powder 1-5 parts, white kidney bean powder 1-4 parts, winter melon seed powder 0.5-3 parts, 2-oxoglutaric acid 0.5-3 parts, pyrroloquinoline quinone disodium salt 0.01-0.1 parts, tricholoma matsutake concentrated powder 0.5-3 parts, gamma-aminobutyric acid 0.1-0.5 parts, spina date seed powder 1-5 parts, poria cocos powder 1-5 parts, Baizhi powder 0.2-1.5 parts, earthworm protein 0.5-3 parts, vitamin D3 0.0001-0.001 parts, steviol glycoside 0.1-1 parts.

[0012] The preparation method of the above composition, after pretreatment of each raw material according to particle size, density, solubility and functional properties, then mixed in sections.

[0013] Further, the specific steps are as follows: (1) The bone collagen peptide, fish collagen tripeptide, wheat oligopeptide, and corn oligopeptide powder are crushed and passed through an 80-mesh screen to obtain component A; (2) The jujube, Danfeng peony flower, licorice, orange peel, high-quality ginger, daidai flower, baizhi, cassia, heavy-petaled red rose, yam powder, yiyiren powder, gualou powder, bai-doufu powder, deng-guaren powder, suanzhiren powder, fuling powder, dried ginger, malt, chrysanthemum powder, sand pear powder, phyllanthus emblica fruit powder, and baizhi powder are dried at low temperature, combined, crushed, and passed through a 100-mesh screen to obtain component B; (3) The grape seed extract, epigallocatechin gallate, xuelian culture, aurantiovitrum concentrated powder, and dilon protein are mixed with part of the malt dextrin to obtain component C; (4) The oligoisomaltose, xylo-oligosaccharide, chrysanthemum powder, small-molecule citrus pectin, and chitosan oligosaccharide are mixed uniformly to obtain component D; (5) The brown sugar, the remaining malt dextrin, and stevioside are mixed and passed through a 60-mesh screen, and then vitamin D3 is dissolved in a small amount of edible alcohol and sprayed onto the mixture, and after drying, component E is obtained; (6) Nicotinamide, 2-oxoglutaric acid, pyrroloquinoline quinone disodium salt, and gamma-aminobutyric acid are mixed to obtain component F; (7) Components B, D, and E are put into a mixing machine for primary mixing, then component A is slowly added for secondary mixing, and components C and F are continuously added for final mixing.

[0014] The beneficial effects achieved are that the preparation method solves the problems of uneven mixing, poor taste, and layering caused by the difference in physical properties of multiple components through scientific grouping pretreatment and segmented mixing process, and ensures the uniform distribution of key active ingredients in the product.

[0015] Further, the mixing parameters are 20-25 rpm for 15-20 min.

[0016] The composition described above is applied in the preparation of health care products for improving immunity and delaying aging.

[0017] According to the above technical solution, compared with the prior art, the present application has the following beneficial effects: The present application realizes the dual effects of immune improvement and aging delay through multi-system cooperation and multi-target intervention. The product has the advantages of stable composition, uniform activity, and good solubility through scientific compounding and special process preparation. Animal experiments and theoretical models show that it can effectively protect immune organs and reduce the accumulation of aging markers, providing a solution for developing comprehensive anti-aging health products. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Example 1 A composition for enhancing immunity and delaying aging comprises the following components in parts by weight: 10 parts collagen peptides, 3 parts fish collagen tripeptides, 2 parts jujubes, 1 part peony flower, 0.5 parts dried ginger, 1 part malt, 0.5 parts licorice, 1 part orange peel, 0.2 parts galangal, 0.5 parts bitter orange blossom, 0.2 parts angelica dahurica, 0.2 parts cinnamon, 1 part double-petaled red rose, 5 parts brown sugar, 20 parts maltodextrin, 2 parts wheat oligopeptides, 1 part corn oligopeptide powder, 1 part grape seed extract, 0.1 part epigallocatechin gallate, 0.5 parts chrysanthemum powder, 0.05 parts niacinamide, and sea buckthorn powder. 1 part, Phyllanthus emblica fruit powder 0.5 parts, Saussurea involucrata culture 0.1 parts, isomaltooligosaccharide 3 parts, xylooligosaccharide 1 part, inulin 5 parts, small molecule citrus pectin 1 part, chitosan oligosaccharide 0.5 parts, yam powder 2 parts, coix seed powder 2 parts, kudzu root powder 1 part, white hyacinth bean powder 1 part, winter melon seed powder 0.5 parts, 2-oxoglutaric acid 0.5 parts, disodium pyrroloquinoline quinone 0.01 parts, Pleurotus ostreatus concentrated powder 0.5 parts, γ-aminobutyric acid 0.1 parts, jujube seed powder 1 part, Poria cocos powder 1 part, Angelica dahurica powder 0.2 parts, earthworm protein 0.5 parts, vitamin D3 0.0001 parts, steviol glycoside 0.1 parts.

[0020] The preparation method includes the following steps: (1) After pulverizing the collagen peptides, fish collagen tripeptides, wheat oligopeptides and corn oligopeptides, pass them through an 80-mesh sieve to obtain component A; (2) After drying the jujube, peony flower, licorice, orange peel, galangal, bitter orange flower, angelica, cinnamon, double-petaled red rose, yam powder, coix seed powder, kudzu root powder, white hyacinth bean powder, winter melon seed powder, sour jujube seed powder, poria powder, dried ginger, malt, chrysanthemum powder, sea buckthorn powder, amla fruit powder, and angelica powder at low temperature, combine them, pulverize them, and pass them through a 100-mesh sieve to obtain component B; (3) Grape seed extract, epigallocatechin gallate, snow lotus culture, golden top pleurotus ostreatus concentrate powder, earthworm protein, and a portion of maltodextrin were mixed to obtain component C; (4) Mix isomaltooligosaccharide, xylooligosaccharide, inulin, small molecule citrus pectin and chitosan oligosaccharide evenly to obtain component D; (5) Mix brown sugar, the remaining maltodextrin and steviol glycosides and pass through a 60-mesh sieve. Then dissolve vitamin D3 in a small amount of edible ethanol and spray it onto the mixture. After drying, obtain component E. (6) Mix nicotinamide, 2-oxoglutaric acid, disodium pyrroloquinoline quinone, and γ-aminobutyric acid to obtain component F; (7) Add components B, D and E to the mixer for primary mixing at 20 rpm for 20 min; then slowly add component A for secondary mixing at 25 rpm for 20 min; continue to add components C and F for final mixing at 20 rpm for 20 min.

[0021] Example 2 A composition for enhancing immunity and delaying aging comprises the following components in parts by weight: 25 parts collagen peptides, 10 parts fish collagen tripeptide, 8 parts jujube, 5 parts peony flower, 3 parts dried ginger, 5 parts malt, 3 parts licorice, 4 parts tangerine peel, 1.5 parts galangal, 2 parts bitter orange blossom, 1.5 parts angelica dahurica, 1.5 parts cinnamon, 4 parts double-petaled red rose, 15 parts brown sugar, 50 parts maltodextrin, 8 parts wheat oligopeptides, 5 parts corn oligopeptide powder, 5 parts grape seed extract, 2 parts epigallocatechin gallate, 3 parts chrysanthemum powder, and 0.3 parts niacinamide. Sea buckthorn powder 4 parts, amla fruit powder 3 parts, snow lotus culture 1 part, isomaltooligosaccharide 10 parts, xylooligosaccharide 5 parts, inulin 15 parts, small molecule citrus pectin 4 parts, chitosan oligosaccharide 3 parts, yam powder 8 parts, coix seed powder 8 parts, kudzu root powder 5 parts, white hyacinth bean powder 4 parts, winter melon seed powder 3 parts, 2-oxoglutarate 3 parts, pyrroloquinoline quinone disodium salt 0.1 parts, golden pine mushroom concentrated powder 3 parts, γ-aminobutyric acid 0.5 parts, jujube seed powder 5 parts, poria cocos powder 5 parts, angelica dahurica powder 1.5 parts, earthworm protein 3 parts, vitamin D3 0.00 1 part, steviol glycoside 1 part.

[0022] The preparation method is the same as in Example 1.

[0023] Example 3 A composition for enhancing immunity and delaying aging comprises the following components in parts by weight: 15 parts collagen peptides, 7 parts fish collagen tripeptide, 5 parts jujube, 3 parts peony flower, 1.5 parts dried ginger, 3 parts malt, 1 part licorice, 2 parts orange peel, 0.8 parts galangal, 1.2 parts bitter orange flower, 0.7 parts angelica, 0.5 parts cinnamon, 2 parts double-petaled red rose, 10 parts brown sugar, 35 parts maltodextrin, 5 parts wheat oligopeptides, 3 parts corn oligopeptide powder, 2 parts grape seed extract, 0.8 parts epigallocatechin gallate, 1.8 parts chrysanthemum powder, 0.15 parts niacinamide, and sea buckthorn. 2 parts powder, 1.8 parts amla fruit powder, 0.5 parts snow lotus culture, 7 parts isomaltooligosaccharide, 4 parts xylooligosaccharide, 11 parts inulin, 2 parts small molecule citrus pectin, 1.5 parts chitosan oligosaccharide, 4 parts yam powder, 6 parts coix seed powder, 4 parts kudzu root powder, 2 parts white hyacinth bean powder, 0.5 parts winter melon seed powder, 0.5 parts 2-oxoglutaric acid, 0.1 parts disodium pyrroloquinoline quinone, 2 parts concentrated powder of Pleurotus ostreatus, 0.3 parts γ-aminobutyric acid, 3 parts jujube seed powder, 3 parts Poria cocos powder, 1 part Angelica dahurica powder, 1.8 parts earthworm protein, 0.0005 parts vitamin D3, and 0.7 parts steviol glycosides.

[0024] The preparation method is the same as in Example 1.

[0025] Experiment 1 Immunity Enhancement Experiment Kunming mice, weighing 15-25g, were housed in cages of 8, with free access to food and water, and kept at room temperature (25℃) under natural light. Suspensions prepared from the compositions of Examples 1-3 were administered to the mice via gavage (20mg / day, based on the weight of the composition), repeated for 10 days. The control group was administered an equal volume of physiological saline via gavage. After 10 days, all mice except the control group were irradiated with cobalt-60-γ at a dose of 5Gy. Mice in each group were weighed, euthanized by blood collection from the orbital rim, and the thymus and spleen were harvested and weighed. The thymus index and spleen index were calculated using the following formulas: Thymus index = thymus weight (mg) / mouse weight (g); Spleen index = spleen weight (mg) / mouse weight (g).

[0026] Table 1 Results of thymus index and spleen index

[0027] The experimental results show that the composition prepared in this invention significantly enhances the immunity of mice.

[0028] Example 2 Anti-aging experiment Lipofuscin, also known as senile pigment, is composed of fat residues and lysosomal digests. Its formation is usually closely related to oxidative stress and cell damage, and its content increases with age, making it one of the important markers of aging.

[0029] Wild-type N2 *C. elegans* nematodes at the L4 stage of synchronization were transferred to NGM medium containing FUDR (20 μmol) and cultured at 20°C. The control group was treated with physiological saline, while the experimental groups were treated with the compositions prepared in Examples 1-3, respectively. On day 10 of adulthood, 10 nematodes were randomly selected and transferred to a slide containing 20 μL of levamisole hydrochloride solution. After anesthetizing the nematodes, their bodies were positioned upright, and the autofluorescence intensity of lipofuscin was observed using an upright fluorescence microscope. Simultaneously, the relative autofluorescence level of lipofuscin was measured using ImageJ software.

[0030] The results are shown in the table below.

[0031] Table 2. Lipofuscin fluorescence (%)

[0032] As can be seen from Table 2, compared with the control group, the lipofuscin content of the nematodes in the treatment group treated with the composition of the present invention was significantly lower on the 10th day after treatment, indicating that the composition of the present invention has a significant anti-aging effect on nematodes.

[0033] Experiment 3 Subjects: Individuals with chronically weakened immune systems.

[0034] Inclusion criteria: Age 20-60 years, gender not limited.

[0035] Meets the objective criteria for "low immunity" (meets at least two of the following): The patient has had ≥4 colds in the past year; serum immunoglobulin IgG levels are at the lower limit of normal (or below the reference range); T cell subset CD4+ / CD8+ ratio <1.0 (or below the laboratory reference range); and the patient reports feeling fatigued with a fatigue scale score of mild or higher.

[0036] Exclusion criteria: Individuals with autoimmune diseases, severe liver or kidney diseases, malignant tumors, HIV, or other diseases affecting the immune system; those who have used immunosuppressants, glucocorticoids, or other drugs / health products affecting immune function within one month prior to the test; pregnant women, breastfeeding women, or those planning to become pregnant; and those allergic to any component of this product.

[0037] Experimental method: Eighty subjects were selected according to the above diagnostic criteria and randomly divided into four groups of 20 subjects each. There were no significant differences between the groups.

[0038] The experimental groups took the compositions prepared in Examples 1 to 3 of this invention, 4g once a day; one cycle was 7 consecutive days, and after 3 cycles, immunoglobulin tests were performed.

[0039] Evaluation metrics: IGM, IGG, and IGA metrics.

[0040] The results are shown in Table 3.

[0041] Table 3 Results of immune indicators

[0042] The above results indicate that the composition of the present invention can improve immune indicators and has a good effect on improving immunity.

[0043] Experiment 4 Solubility determination Determination method: Take 0.5g of sample into a 50mL beaker, add 10mL of distilled water, and stir with a magnetic stirrer for 10min to ensure uniform dispersion of the sample in the water. Centrifuge for 10min at 25℃ and 6000r / min. After centrifugation, transfer the supernatant to a pre-weighed petri dish and dry at 105℃ until constant weight. The solubility calculation formula is as follows: Solubility (%) = [(m-m1) / m] × 100%.

[0044] In the formula: m is the mass of the powder sample weighed, in g; m1 is the weight of the sample after drying.

[0045] The results are shown in Table 4.

[0046] Table 4 Solubility (%)

[0047] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0048] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A composition for improving immunity and delaying aging, characterized by comprising: The composition comprises the following components in mass fraction: collagen 5-50 parts, Danfeng peony tea 10-80 parts, antioxidant 1-20 parts, intestinal microecological regulator 3-10 parts, and energy metabolism and nerve regulator 1-3 parts. ​ 2. The composition of claim 1, wherein, the collagen is one or both of bone collagen peptide and fish collagen tripeptide; the Danfeng peony tea comprises jujube, Danfeng peony flower, dried ginger, malt, licorice, orange peel, high-quality ginger, daye flower, baizhi, cassia, double-petaled red rose, brown sugar, malt dextrin, wheat oligopeptide, and corn oligopeptide powder; the antioxidant is one or more of grape seed extract, epigallocatechin gallate, chrysanthemum powder, nicotinamide, sea buckthorn powder, phyllium fruit powder, and saussurea culture; the intestinal microecological regulator is one or more of isomaltooligosaccharide, xylooligosaccharide, inulin, small molecule citrus pectin, chitooligosaccharide, yam powder, yiyi ren powder, gualou powder, white mung bean powder, and winter melon kernel powder; the energy metabolism and nerve regulator is one or more of 2-oxoglutaric acid, pyrroloquinoline quinone disodium salt, tremella fuciformis concentrate powder, gamma-aminobutyric acid, spina date seed powder, poria cocos powder, baizhi powder, earthworm protein, and vitamin D3.

3. The composition of claim 1, wherein The composition further comprises a flavoring agent.

4. The composition of claim 1, wherein The composition comprises the following components in mass fraction: bone collagen peptide 10-25 parts, fish collagen tripeptide 3-10 parts, jujube 2-8 parts, Danfeng peony flower 1-5 parts, dried ginger 0.5-3 parts, malt 1-5 parts, licorice 0.5-3 parts, orange peel 1-4 parts, high-quality ginger 0.2-1.5 parts, daye flower 0.5-2 parts, baizhi 0.2-1.5 parts, cassia 0.2-1.5 parts, double-petaled red rose 1-4 parts, brown sugar 5-15 parts, malt dextrin 20-50 parts, wheat oligopeptide 2-8 parts, corn oligopeptide powder 1-5 parts, grape seed extract 1-5 parts, epigallocatechin gallate 0.1-2 parts, chrysanthemum powder 0.5-3 parts, nicotinamide 0.05-0.3 parts, sea buckthorn powder 1-4 parts, phyllium fruit powder 0.5-3 parts, saussurea culture 0.1-1 parts, isomaltooligosaccharide 3-10 parts, xylooligosaccharide 1-5 parts, inulin 5-15 parts, small molecule citrus pectin 1-4 parts, chitooligosaccharide 0.5-3 parts, yam powder 2-8 parts, yiyi ren powder 2-8 parts, gualou powder 1-5 parts, white mung bean powder 1-4 parts, winter melon kernel powder 0.5-3 parts, 2-oxoglutaric acid 0.5-3 parts, pyrroloquinoline quinone disodium salt 0.01-0.1 parts, tremella fuciformis concentrate powder 0.5-3 parts, gamma-aminobutyric acid 0.1-0.5 parts, spina date seed powder 1-5 parts, poria cocos powder 1-5 parts, baizhi powder 0.2-1.5 parts, earthworm protein 0.5-3 parts, and vitamin D3 0.0001-0.001 parts, and steviol glycoside 0.1-1 parts.

5. The composition of claim 1, wherein Components including the following mass parts: bone collagen peptide 15 parts, fish collagen tripeptide 7 parts, jujube 5 parts, Danfeng peony flower 3 parts, dried ginger 1.5 parts, malt 3 parts, licorice 1 part, orange peel 2 parts, hokkaido 0.8 parts, daye flower 1.2 parts, baizhi 0.7 parts, cassia 0.5 parts, double red rose 2 parts, brown sugar 10 parts, malt dextrin 35 parts, wheat oligopeptide 5 parts, corn oligopeptide powder 3 parts, grape seed extract 2 parts, epigallocatechin gallate 0.8 parts, chrysanthemum powder 1.8 parts, nicotinamide 0.15 parts, sea buckthorn powder 2 parts, phyllanthus emblica fruit powder 1.8 parts, snow lotus culture 0.5 parts, isomalto-oligosaccharide 7 parts, xylo-oligosaccharide 4 parts, inulin 11 parts, small molecule citrus pectin 2 parts, chitooligosaccharide 1.5 parts, yam powder 4 parts, coix seed powder 6 parts, kudzu root powder 4 parts, white lentil powder 2 parts, winter melon seed powder 0.5 parts, 2-oxoglutaric acid 0.5 parts, pyrroloquinoline quinone disodium salt 0.1 parts, tricholoma matsutake concentrated powder 2 parts, gamma-aminobutyric acid 0.3 parts, spina date seed powder 3 parts, poria cocos powder 3 parts, baizhi powder 1 part, earthworm protein 1.8 parts, vitamin D3 0.0005 parts, steviol glycosides 0.7 parts.

6. Process for the preparation of a composition according to any one of claims 4-5, characterized in that, After the raw materials are pretreated according to particle size, density, solubility and functional properties, they are mixed in sections.

7. The production method according to claim 6, wherein The specific steps are as follows: (1) The bone collagen peptide, fish collagen tripeptide, wheat oligopeptide and corn oligopeptide powder are crushed and passed through an 80-mesh screen to obtain component A; (2) The jujube, Danfeng peony flower, licorice, orange peel, hokkaido, daye flower, baizhi, cassia, double red rose, yam powder, coix seed powder, kudzu root powder, white lentil powder, winter melon seed powder, spina date seed powder, poria cocos, dried ginger, malt, chrysanthemum powder, sea buckthorn powder, phyllanthus emblica fruit powder and baizhi powder are dried at low temperature, crushed and passed through a 100-mesh screen to obtain component B; (3) The grape seed extract, epigallocatechin gallate, snow lotus culture, tricholoma matsutake concentrated powder and earthworm protein are mixed with part of the malt dextrin to obtain component C; (4) The isomalto-oligosaccharide, xylo-oligosaccharide, inulin and small molecule citrus pectin are mixed uniformly to obtain component D; (5) The brown sugar, the remaining malt dextrin and steviol glycosides are mixed and passed through a 60-mesh screen, then the vitamin D3 is dissolved in a small amount of edible alcohol and sprayed onto the mixture, and after drying, component E is obtained; (6) The nicotinamide, 2-oxoglutaric acid, pyrroloquinoline quinone disodium salt and gamma-aminobutyric acid are mixed to obtain component F; (7) Components B, D and E are put into a mixer for primary mixing, then component A is slowly added for secondary mixing; Components C and F are continuously added for final mixing.

8. The method of claim 7, wherein, The mixing parameters are 20-25 rpm for 15-20 min.

9. Use of the composition of any one of claims 1-5 in the preparation of health products for improving immunity and delaying aging.

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