Preparation method for synthesizing anti-aging medicine from fermentation of traditional Chinese medicine composition and NMN

Abstract

The invention discloses a preparation method for synthesizing an anti-aging drug through fermentation of a traditional Chinese medicine composition and NMN, and relates to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: raw material compatibility and pretreatment: taking 10-30 parts by mass of rhizoma polygonati, 8-25 parts by mass of lucid ganoderma, 5-20 parts by mass of roxburgh rose, 5-20 parts by mass of lily, 5-20 parts by mass of radix rehmanniae preparata, 5-20 parts by mass of American ginseng, 3-15 parts by mass of pseudo-ginseng, 3-15 parts by mass of syngnathus, 3-15 parts by mass of hippocampus and 5-20 parts by mass of herba epimedii; polygonatum sibiricum and ganoderma lucidum are used as monarch drugs to tonify qi, nourish yin, soothe nerves and promote intelligence; animal medicinal materials such as syngnathus, hippocampus and penis et testis cervi are matched to tonify the kidney, strengthen yang and strengthen In combination with modern anti-aging components of NMN, cell energy is activated, and the aging process is delayed in multiple ways; macromolecular substances are converted into micromolecular active components through fermentation of the compound probiotics, so that the absorption rate is increased; the activity of heat-sensitive components is protected by low-temperature crushing and drying processes; the stability and the palatability of the product are ensured through the scientific matching of the auxiliary materials; tests prove that the traditional Chinese medicine composition has multiple effects of resisting fatigue, improving sleep, enhancing sexual function, improving immunity and the like.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically a method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition. Background Technology

[0002] With the accelerating aging of the population, the demand for anti-aging products is growing. Currently, anti-aging products on the market can be mainly divided into the following categories: chemically synthesized drugs, such as antioxidants and hormone replacement agents, but long-term use carries the risk of side effects; single herbal extracts, such as ginsenosides and astragalus polysaccharides, have limited efficacy and are difficult to achieve holistic conditioning; ordinary health supplements, with simple ingredients and lacking systematic and synergistic effects; and modern biological agents, such as NMN, which are expensive and have limited effects from single ingredients.

[0003] Existing technologies have the following shortcomings: the products have limited efficacy and it is difficult to achieve multi-target anti-aging; the utilization rate of effective components of traditional Chinese medicine is low and the bioavailability is poor; the traditional Chinese medicine preparation process is backward and the quality is unstable; the modern anti-aging components are not closely integrated with traditional Chinese medicine; and there is a lack of systematic pharmacological research and clinical validation. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a method for preparing anti-aging drugs through fermentation of traditional Chinese medicine compositions and synthesis of NMN, which solves the following deficiencies of existing technologies: the products have single efficacy and are difficult to achieve multi-target anti-aging; the utilization rate of effective components of traditional Chinese medicine is low and the bioavailability is poor; the traditional Chinese medicine preparation process is backward and the quality is unstable; the modern anti-aging components are not closely combined with traditional Chinese medicine; and there is a lack of systematic pharmacological research and clinical verification.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition, comprising the following steps: (1) Raw material compatibility and pretreatment: Take 10-30 parts of Polygonatum sibiricum, 8-25 parts of Ganoderma lucidum, 5-20 parts of Prickly pear, 5-20 parts of Lilium brownii, 5-20 parts of Rehmannia glutinosa, 5-20 parts of Panax quinquefolius, 3-15 parts of Panax notoginseng, 3-15 parts of Spatholobus suberectus, 3-15 parts of Hippophae rhamnoides, 5-20 parts of Epimedium brevicornu, 3-15 parts of Dendrobium huoshanense, 5-20 parts of Gastrodia elata, 3-15 parts of Saussurea involucrata, 3-15 parts of Amomum villosum, 5-20 parts of Polygonum multiflorum, 3-15 parts of Yinqishi (a type of mineral), 3-15 parts of Yangqishi (another type of mineral), 5-20 parts of Astragalus membranaceus, 5-20 parts of Maca, 1-10 parts of Cordyceps sinensis, 3-15 parts of black dog penis, and 3-15 parts of sika deer penis according to the following mass proportions: After washing, the plant-based medicinal materials are dried at a low temperature of 50-60℃ until the moisture content is below 8%, while the animal-based medicinal materials are freeze-dried. (2) Ultrafine grinding: Mix the pretreated medicinal materials and grind them to a particle size of 40-80 mesh using ultrafine grinding technology to obtain uniform medicinal material particles; (3) Fermentation with compound microbial agent: Add 30%-50% of the mass of the medicinal material to the medicinal material granules with purified water, and inoculate with 5%-15% of the mass of the medicinal material with compound probiotic agent, and ferment at 35-42℃ for 15-30 days; the compound probiotic agent is composed of brewer's yeast, lactobacillus plantarum and bifidobacterium in a live bacteria ratio of (2-4):(1-3):1; (4) Fermentation product treatment: The fermentation product is concentrated at a low temperature of 45-55℃ to 1 / 3-1 / 2 of its original volume to obtain fermentation concentrate; (5) NMN addition and mixing: Add NMN (nicotinamide mononucleotide) to the fermentation concentrate. The amount of NMN added is 1%-5% of the total mass of the final product. Stir until completely dissolved. (6) Addition of pharmaceutical excipients: Add the following pharmaceutical excipients in sequence: Binding agent: 5-15 parts raw honey, 3-10 parts cane sugar; Filler: 10-25 parts microcrystalline cellulose, 5-15 parts pregelatinized starch; Wetting agent: 1-5 parts of polyethylene glycol 400; Flavoring agents: 0.1-1 parts steviol glycosides, 0.05-0.5 parts menthol; Preservative: 0.1-0.5 parts potassium sorbate; Antioxidant: Vitamin E 0.05-0.3 parts; (7) Pelletizing: The mixture is prepared into pellets with a particle size of 18-22 mm using an extrusion spheronizing pellet mill, with each pellet weighing 5-7 grams; (8) Drying and packaging: Dry the pills at 40-50℃ until the moisture content is less than 6%, and then package them in white medical plastic round boxes, 30 pills per box.

[0006] Preferably, the mass fractions of the raw materials mentioned in step (1) are: 15-25 parts of Polygonatum sibiricum, 10-20 parts of Ganoderma lucidum, 8-15 parts of Prickly pear, 8-15 parts of Lilium brownii, 8-15 parts of Rehmannia glutinosa, 8-15 parts of Panax quinquefolius, 5-10 parts of Panax notoginseng, 5-10 parts of Spatholobus suberectus, 5-10 parts of Hippophae rhamnoides, 8-15 parts of Epimedium brevicornu, 5-10 parts of Dendrobium nobile, 8-15 parts of Gastrodia elata, 5-10 parts of Saussurea involucrata, 5-10 parts of Amomum villosum, 8-15 parts of Polygonum multiflorum, 5-10 parts of Yinqishi (a type of mineral), 5-10 parts of Yangqishi (another type of mineral), 8-15 parts of Astragalus membranaceus, 8-15 parts of Maca, 3-8 parts of Cordyceps sinensis, 5-10 parts of black dog penis, and 5-10 parts of sika deer penis.

[0007] Preferably, the ultrafine grinding in step (2) adopts low temperature grinding technology, and the temperature is controlled not to exceed 35°C during the grinding process.

[0008] Preferably, the inoculation amount of the compound probiotic agent in step (3) is 10%, and the ratio of live bacteria of the brewer's yeast, lactobacillus plantarum and bifidobacterium is 3:2:1.

[0009] Preferably, the fermentation in step (3) is controlled in two stages: aerobic fermentation at 38-42℃ for the first 5-10 days, and anaerobic fermentation at 35-38℃ for the next 10-20 days.

[0010] Preferably, the pharmaceutical excipients in step (6) further include: Disintegrants: 2-8 parts crospovidone, 1-5 parts sodium carboxymethyl starch; Lubricant: 0.5-2 parts magnesium stearate, 0.3-1 part micronized silica gel; Coating agent: 3-10 parts of Opadry film coating premix.

[0011] Preferably, in step (6), 0.5%-2% of a natural plant pigment is added, which is one or more of gardenia yellow, beet red or curcumin.

[0012] Preferably, the pelleting in step (7) employs centrifugal granulation technology, with the pelleting speed controlled at 800-1200 rpm and the pellet density controlled at 1.2-1.5 g / cm³. 3 .

[0013] Preferably, the drying in step (8) adopts a fluidized bed drying process with an inlet temperature of 50°C, an outlet temperature of 40°C, and a drying time of 20-40 minutes.

[0014] Beneficial effects This invention provides a method for preparing an anti-aging drug through fermentation of a traditional Chinese medicine composition and synthesis of NMN, overcoming the following shortcomings of existing technologies: single product efficacy, difficulty in achieving multi-target anti-aging; low utilization rate and poor bioavailability of effective components in traditional Chinese medicine; outdated traditional Chinese medicine preparation processes and unstable quality; insufficient integration of modern anti-aging components with traditional Chinese medicine; and a lack of systematic pharmacological research and clinical validation. This invention has the following advantages: using Polygonatum sibiricum and Ganoderma lucidum as principal herbs to replenish qi and nourish yin, calm the mind and improve intelligence; combined with animal medicinal materials such as seahorse, sea dragon, and deer antler velvet to tonify the kidneys and strengthen yang, and to strengthen muscles and bones; and combined with modern anti-aging components such as NMN to activate... Cellular energy slows down the aging process through multiple pathways; compound probiotic fermentation transforms macromolecules into small-molecule active ingredients, improving absorption rate; low-temperature pulverization and drying processes protect the activity of heat-sensitive components; scientific excipient ratios ensure product stability and palatability; proven to have multiple effects such as anti-fatigue, improved sleep, enhanced sexual function, and improved immunity; combines traditional Chinese medicine's holistic conditioning with modern targeted ingredient action; all raw materials are natural, and scientific formulation reduces side effects; a strict quality control system ensures product safety and effectiveness; the pill dosage form is convenient to carry and take; precise dosage control guarantees the stability of therapeutic effects. Detailed Implementation

[0015] The present invention will be further described in detail below through specific embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of the invention.

[0016] Example 1: A method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition, comprising the following steps: (1) Raw material compatibility and pretreatment: Take 20 parts of Polygonatum sibiricum, 15 parts of Ganoderma lucidum, 10 parts of Prickly pear, 10 parts of Lilium brownii, 10 parts of Rehmannia glutinosa, 10 parts of Panax quinquefolius, 8 parts of Panax notoginseng, 8 parts of sea dragon, 8 parts of seahorse, 10 parts of Epimedium brevicornu, 8 parts of Dendrobium huoshanense, 10 parts of Gastrodia elata, 8 parts of Saussurea involucrata, 8 parts of Amomum villosum, 10 parts of Polygonum multiflorum, 8 parts of Yinqishi, 8 parts of Yangqishi, 10 parts of Astragalus membranaceus, 10 parts of Maca, 5 parts of Cordyceps sinensis, 8 parts of black dog penis, and 8 parts of sika deer penis according to the following mass proportions; After washing, the plant-based medicinal materials are dried at a low temperature of 55℃ until the moisture content is less than 7%, while the animal-based medicinal materials are freeze-dried. (2) Ultrafine grinding: The pretreated medicinal materials are mixed and then ground to a particle size of 60 mesh using ultrafine grinding technology to obtain uniform medicinal material particles; (3) Compound microbial fermentation: Add 40% of the mass of purified water to the medicinal material granules, and add 10% of the mass of compound probiotics to the granules. The first 7 days are aerobic fermentation at 40℃, and the next 18 days are anaerobic fermentation at 36℃. The compound probiotics are composed of brewer's yeast, lactobacillus plantarum and bifidobacterium in a live bacteria ratio of 3:2:1. (4) Fermentation product treatment: The fermentation product is concentrated at 50°C to 2 / 5 of its original volume to obtain fermentation concentrate; (5) NMN addition and mixing: Add NMN (nicotinamide mononucleotide) to the fermentation concentrate. The amount of NMN added is 3% of the total mass of the final product. Stir until completely dissolved. (6) Addition of pharmaceutical excipients: Add the following pharmaceutical excipients in sequence: 10 parts raw honey, 6 parts cane sugar, 18 parts microcrystalline cellulose, 10 parts pregelatinized starch, 3 parts polyethylene glycol 400, 5 parts crospovidone, 3 parts sodium carboxymethyl starch, 1 part magnesium stearate, 0.6 parts micronized silica gel, 0.5 parts steviol glycosides, 0.2 parts menthol, 0.3 parts potassium sorbate, 0.2 parts vitamin E, 6 parts Opadry film coating premix, 1% gardenia yellow; (7) Pelletizing: The mixture is prepared by extrusion spheronization granulation machine, centrifuged at 1000 rpm, and 20 mm pills are prepared, each weighing 6 grams; (8) Drying and packaging: Fluidized bed drying, inlet 50℃, outlet 40℃, drying for 30 minutes until the moisture content is less than 6%, packaged in white medical plastic round boxes, 30 tablets per box.

[0017] Example 2: A method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition, comprising the following steps: (1) Raw material compatibility and pretreatment: Take 30 parts of Polygonatum sibiricum, 25 parts of Ganoderma lucidum, 20 parts of Prickly pear, 20 parts of Lilium brownii, 20 parts of Rehmannia glutinosa, 20 parts of Panax quinquefolius, 15 parts of Panax notoginseng, 15 parts of sea dragon, 15 parts of seahorse, 20 parts of Epimedium brevicornu, 15 parts of Dendrobium huoshanense, 20 parts of Gastrodia elata, 15 parts of Saussurea involucrata, 15 parts of Amomum villosum, 20 parts of Polygonum multiflorum, 15 parts of Yinqishi, 15 parts of Yangqishi, 20 parts of Astragalus membranaceus, 20 parts of Maca, 10 parts of Cordyceps sinensis, 15 parts of black dog penis, and 15 parts of sika deer penis according to the following mass proportions: After washing, the plant-based medicinal materials are dried at a low temperature of 60℃ until the moisture content is less than 8%, while the animal-based medicinal materials are freeze-dried. (2) Ultrafine grinding: The pretreated medicinal materials are mixed and then ground to a particle size of 80 mesh using ultrafine grinding technology to obtain uniform medicinal material particles; (3) Compound microbial fermentation: Add 50% of the mass of purified water to the medicinal material granules, and add 15% of the mass of compound probiotics to the granules. The first 10 days are for aerobic fermentation at 35℃, and the next 20 days are for anaerobic fermentation at 42℃. The compound probiotics are composed of brewer's yeast, lactobacillus plantarum and bifidobacterium in a live bacteria ratio of 4:3:1. (4) Fermentation product treatment: The fermentation product is concentrated at 55℃ to half of its original volume to obtain fermentation concentrate; (5) NMN addition and mixing: Add NMN (nicotinamide mononucleotide) to the fermentation concentrate. The amount of NMN added is 5% of the total mass of the final product. Stir until completely dissolved. (6) Addition of pharmaceutical excipients: Add the following pharmaceutical excipients in sequence: 15 parts raw honey, 10 parts cane sugar, 25 parts microcrystalline cellulose, 15 parts pregelatinized starch, 5 parts polyethylene glycol 400, 8 parts crospovidone, 5 parts sodium carboxymethyl starch, 2 parts magnesium stearate, 1 part micronized silica gel, 1 part steviol glycosides, 0.5 parts menthol, 0.5 parts potassium sorbate, 0.3 parts vitamin E, 10 parts Opadry film coating premix, 2% gardenia yellow; (7) Pelletizing: The mixture is prepared using an extrusion spheronization granulator, centrifuged to produce pellets with a particle size of 22 mm, each weighing 7 grams, at a rotation speed of 1200 rpm, and a pellet density of 1.5 g / cm³. 3 ; (8) Drying and packaging: Fluidized bed drying, inlet 50℃, outlet 40℃, drying for 40 minutes until the moisture content is 6%, packaged in white medical plastic round boxes, 30 tablets per box.

[0018] Comparative Example 1 Traditional preparation method: According to the formula in Example 1, the medicinal materials are conventionally pulverized and directly made into pills without fermentation.

[0019] Comparative Example 2 Commercially available anti-aging product: NMN capsules from a certain brand.

[0020] Physicochemical index testing Testing items Example 1 Comparative Example 1 Comparative Example 2 Difference in pill weight ±3.2% ±8.5% ±5.2% Dissolution time (min) 25±3 45±8 15±2 Moisture content (%) 5.8 8.2 4.5 Active ingredient content (mg / g) 18.6±1.2 9.3±2.1 22.5±1.8 Stability test Accelerated testing for 6 months at 40℃ and 75% relative humidity: Example 1: No change in appearance, 96.3% retention rate of active ingredients; Comparative Example 1: Hardening occurred, with an effective ingredient retention rate of 78.5%; Comparative Example 2: Slight discoloration, with an effective ingredient retention rate of 88.7%.

[0021] Efficacy Evaluation 150 middle-aged people with sub-health conditions were selected and randomly divided into three groups: Example 1 group: Take one pill of the Baochun Dan of this invention daily; Comparative Group 1: Take one traditionally made pill daily; Comparative Group 2: Administered commercially available NMN capsules at the recommended daily dose; Observe the efficacy after 12 weeks of treatment: Group Number of examples Fatigue improvement rate Sleep improvement rate Sexual function improvement rate Immunity enhancement rate Example 1 50 88.0% 82.0% 76.0% 84.0% Comparative Example 1 50 62.0% 58.0% 52.0% 60.0% Comparative Example 2 50 72.0% 68.0% 45.0% 70.0% Safety assessment The incidence of adverse reactions in Group 1 of Example 1 was 6.0%, mainly manifested as mild dry mouth; The incidence of adverse reactions in the comparative group 1 was 14.0%, including indigestion and fever. The incidence of adverse reactions in the comparative group 2 was 10.0%, including dizziness and facial flushing.

[0022] Consumer satisfaction survey The survey considered factors such as the effectiveness, ease of use, and overall satisfaction. Example 1 group satisfaction rate was 94%; In comparison group 1, the satisfaction rate was 72%. The satisfaction rate of the two control groups was 80%.

[0023] Improvement in laboratory indicators Effects on blood biochemical indicators: detection indicators Improvement rate in Example 1 Comparative Example 2 Improvement Rate SOD activity is enhanced. 35.2% 28.6% MDA content decreased 42.8% 31.5% Increased testosterone levels 38.5% 15.2% Improvement of immune function indicators 45.3% 32.7% This invention, through scientific raw material formulation and advanced preparation technology, has successfully developed a comprehensive and safe traditional Chinese medicine composition for fermentation and NMN synthesis, resulting in an anti-aging and youth-preserving pill. Compared with traditional methods, this invention's product has significant advantages in quality stability, efficacy, and safety. In particular, the fermentation process improves the bioavailability of the active ingredients, achieving a perfect combination of traditional Chinese medicine and modern anti-aging technology, providing a high-quality product option for anti-aging health care.

[0024] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

Claims

1. A method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition, characterized in that, Includes the following steps: (1) Raw material compatibility and pretreatment: Take 10-30 parts of Polygonatum sibiricum, 8-25 parts of Ganoderma lucidum, 5-20 parts of Prickly pear, 5-20 parts of Lilium brownii, 5-20 parts of Rehmannia glutinosa, 5-20 parts of Panax quinquefolius, 3-15 parts of Panax notoginseng, 3-15 parts of Spatholobus suberectus, 3-15 parts of Hippophae rhamnoides, 5-20 parts of Epimedium brevicornu, 3-15 parts of Dendrobium huoshanense, 5-20 parts of Gastrodia elata, 3-15 parts of Saussurea involucrata, 3-15 parts of Amomum villosum, 5-20 parts of Polygonum multiflorum, 3-15 parts of Yinqishi (a type of mineral), 3-15 parts of Yangqishi (another type of mineral), 5-20 parts of Astragalus membranaceus, 5-20 parts of Maca, 1-10 parts of Cordyceps sinensis, 3-15 parts of black dog penis, and 3-15 parts of sika deer penis according to the following mass proportions: After washing, the plant-based medicinal materials are dried at a low temperature of 50-60℃ until the moisture content is below 8%, while the animal-based medicinal materials are freeze-dried. (2) Ultrafine grinding: Mix the pretreated medicinal materials and grind them to a particle size of 40-80 mesh using ultrafine grinding technology to obtain uniform medicinal material particles; (3) Fermentation with compound microbial agent: Add 30%-50% of the mass of the medicinal material to the medicinal material granules with purified water, and inoculate with 5%-15% of the mass of the medicinal material with compound probiotic agent, and ferment at 35-42℃ for 15-30 days; the compound probiotic agent is composed of brewer's yeast, lactobacillus plantarum and bifidobacterium in a live bacteria ratio of (2-4):(1-3):1; (4) Fermentation product treatment: The fermentation product is concentrated at a low temperature of 45-55℃ to 1 / 3-1 / 2 of its original volume to obtain fermentation concentrate; (5) NMN addition and mixing: Add NMN (nicotinamide mononucleotide) to the fermentation concentrate. The amount of NMN added is 1%-5% of the total mass of the final product. Stir until completely dissolved. (6) Addition of pharmaceutical excipients: Add the following pharmaceutical excipients in sequence: Binding agent: 5-15 parts raw honey, 3-10 parts cane sugar; Filler: 10-25 parts microcrystalline cellulose, 5-15 parts pregelatinized starch; Wetting agent: 1-5 parts of polyethylene glycol 400; Flavoring agents: 0.1-1 parts steviol glycosides, 0.05-0.5 parts menthol; Preservative: 0.1-0.5 parts potassium sorbate; Antioxidant: Vitamin E 0.05-0.3 parts; (7) Pelletizing: The mixture is prepared into pellets with a particle size of 18-22 mm using an extrusion spheronizing pellet mill, with each pellet weighing 5-7 grams. (8) Drying and packaging: Dry the pills at 40-50℃ until the moisture content is less than 6%, and then package them in white medical plastic round boxes, 30 pills per box.

2. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The mass fractions of the raw materials mentioned in step (1) are as follows: 15-25 parts of Polygonatum sibiricum, 10-20 parts of Ganoderma lucidum, 8-15 parts of Prickly pear, 8-15 parts of Lilium brownii, 8-15 parts of Rehmannia glutinosa, 8-15 parts of Panax quinquefolius, 5-10 parts of Panax notoginseng, 5-10 parts of Spatholobus suberectus, 5-10 parts of Hippophae rhamnoides, 8-15 parts of Epimedium brevicornu, 5-10 parts of Dendrobium nobile, 8-15 parts of Gastrodia elata, 5-10 parts of Saussurea involucrata, 5-10 parts of Amomum villosum, 8-15 parts of Polygonum multiflorum, 5-10 parts of Yinqishi (a type of mineral), 5-10 parts of Yangqishi (another type of mineral), 8-15 parts of Astragalus membranaceus, 8-15 parts of Maca, 3-8 parts of Cordyceps sinensis, 5-10 parts of black dog penis, and 5-10 parts of sika deer penis.

3. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The ultrafine grinding in step (2) adopts low temperature grinding technology, and the temperature is controlled not to exceed 35℃ during the grinding process.

4. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The inoculation amount of the compound probiotic agent in step (3) is 10%, and the ratio of live bacteria of the brewer's yeast, lactobacillus plantarum and bifidobacteria is 3:2:

1.

5. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The fermentation described in step (3) is controlled in two stages: aerobic fermentation at 38-42℃ for the first 5-10 days, and anaerobic fermentation at 35-38℃ for the next 10-20 days.

6. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The pharmaceutical excipients mentioned in step (6) also include: Disintegrants: 2-8 parts crospovidone, 1-5 parts sodium carboxymethyl starch; Lubricant: 0.5-2 parts magnesium stearate, 0.3-1 part micronized silica gel; Coating agent: 3-10 parts of Opadry film coating premix.

7. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, In step (6), 0.5%-2% of natural plant pigments, which are one or more of gardenia yellow, beet red, or curcumin, are added to the final product.

8. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The pelleting process described in step (7) uses centrifugal granulation technology, with the pelleting speed controlled at 800-1200 rpm and the pellet density controlled at 1.2-1.5 g / cm³.

9. The method for preparing an anti-aging drug by fermentation and NMN synthesis of a traditional Chinese medicine composition according to claim 1, characterized in that, The drying process described in step (8) is a fluidized bed drying process with an inlet temperature of 50°C, an outlet temperature of 40°C, and a drying time of 20-40 minutes.