Application of fagopyrum dibotrys freeze-dried powder in preparation of medicine for preventing or treating antimony pneumoconiosis

The freeze-dried buckwheat powder preparation process has solved the technical problem of lacking an effective treatment for antimony pneumoconiosis. The freeze-dried buckwheat powder has shown a significant inhibitory effect on pulmonary fibrosis in the prevention and treatment of antimony pneumoconiosis, providing a new drug intervention and prevention approach for occupational antimony pneumoconiosis.

CN122005656APending Publication Date: 2026-05-12NANTONG UNIV
0 Cites 0 Cited by

Patent Information

Application Number
CN202610378668.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-26
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

There is a lack of effective drug interventions in the current technology to treat or prevent antimony pneumoconiosis, especially for occupational pulmonary fibrosis caused by metallic antimony dust. The application of the traditional Chinese medicine buckwheat lacks theoretical basis and experimental evidence.

Method used

The freeze-dried powder of buckwheat was used as a drug. It was prepared into freeze-dried powder through water extraction, concentration and freeze drying. It was used to alleviate pulmonary fibrosis caused by antimony exposure, reduce collagen deposition and Col-1, α-SMA protein and gene expression in lung tissue, and reduce hydroxyproline content. The preparation process is mature and the quality is controllable.

Benefits of technology

The freeze-dried powder of buckwheat significantly reduces the pathological damage to lung tissue in antimony pneumoconiosis, inhibits excessive collagen expression, and improves inflammatory cell infiltration and fibrosis, providing a new drug intervention strategy for the prevention and treatment of antimony pneumoconiosis and showing good industrialization potential.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention relates to the technical field of biological medicines, in particular to application of wild buckwheat rhizome freeze-dried powder in preparation of a medicine for preventing or treating antimony pneumoconiosis. A mouse antimony pneumoconiosis model is constructed by injecting an antimony (Sb) suspension into a trachea, and pulmonary fibrosis lesion caused by antimony exposure can be remarkably relieved by intragastric administration of the wild buckwheat rhizome freeze-dried powder prepared by the invention. Experimental results show that Hamp; e dyeing indicates that the freeze-dried powder can obviously relieve the fibrosis severity of the lung tissue; western Blot and PCR (Polymerase Chain Reaction) detection results show that the wild buckwheat rhizome can partially inhibit the expression up-regulation of Col-1 and alpha-SMA induced by antimony in protein and gene levels; in addition, the wild buckwheat rhizome can also obviously reduce the content of hydroxyproline in lung tissues. The results show that the wild buckwheat rhizome freeze-dried powder can effectively improve multiple pathological indexes and reduce the pulmonary fibrosis degree, has good potential in the aspect of preventing antimony pneumoconiosis, and has potential application value.
Need to check novelty before this filing date? Find Prior Art