A veterinary drug composition containing Bupleurum chinense extract, its preparation method and application

By optimizing the ratio of saikosaponins a and d and the preparation process, the problems of extraction rate, oxidation rate and storage stability of existing veterinary drugs have been solved, and a highly efficient and safe drug composition suitable for large-scale livestock and poultry farming has been achieved.

CN122075562APending Publication Date: 2026-05-26SHANDONG SANRUN BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511539315.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-27
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing veterinary drugs for the prevention and treatment of liver and gallbladder diseases in livestock and poultry suffer from problems such as low extraction rate, high oxidation rate, incomplete purification, poor storage stability, and unstable efficacy, making it difficult to meet the needs of large-scale farming.

Method used

By optimizing the mass ratio of saikosaponin a to saikosaponin d to 0.8–1.2:1, and employing compound enzymatic hydrolysis, ultrasonic extraction, and resin purification technologies, combined with low-temperature freeze drying, and strictly controlling the excipient ratio and granulation parameters, tablets, granules, or powders were prepared to ensure the extraction rate and stability of the active ingredients.

Benefits of technology

It improves the extraction and oxidation rates of saikosaponins, extends the drug's shelf life, enhances treatment efficiency, reduces production costs, ensures the drug's safety and stability, and meets the needs of large-scale farming.

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Abstract

This invention discloses a veterinary drug composition containing Bupleurum chinense extract, its preparation method, and its application, belonging to the technical field of veterinary traditional Chinese medicine preparations. The composition consists of active ingredients (only saikosaponins a and d, in a mass ratio of 0.8–1.2:1, accounting for 5%–50% of the total content) and excipients (one or more of microcrystalline cellulose, magnesium stearate, and starch). The dosage form is tablets, granules, or powder, with each unit dose containing 5–20 mg of the total mass of both. In preparation, dried Bupleurum chinense roots are pulverized and enzymatically hydrolyzed with a 1:1 complex enzyme, ultrasonically extracted with an ethanol-sodium citrate mixture, purified with AB-8 macroporous resin, and freeze-dried to obtain saikosaponin powder. This powder is then mixed with the excipients and granulated, tableted, or packaged into the corresponding dosage form. This composition shows significant efficacy against fatty liver in chickens, hepatitis in pigs, and cholestasis in ducks, exhibiting stability, high purity, and high efficiency, providing a safe new option for the treatment of liver and gallbladder diseases in livestock and poultry.
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