A traditional Chinese medicine composition for promoting gastrointestinal digestion, its preparation method and application

Abstract

This invention provides a traditional Chinese medicine composition for promoting gastrointestinal digestion, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. The invention provides a traditional Chinese medicine composition for promoting gastrointestinal digestion, comprising the following raw materials in parts by weight: 5-20 parts of charred hawthorn, 5-25 parts of charred Shenqu (medicated leaven), 5-20 parts of charred malt, and 5-20 parts of Poria cocos. The traditional Chinese medicine composition provided by this invention has good clinical efficacy in treating indigestion in infants and young children, indigestion in adults, and slow recovery of spleen and stomach function after surgery. Furthermore, the formulation is scientific, the compatibility is reasonable, the medicinal resources are abundant, the preparation process is simple, it is easy to carry, convenient to use, inexpensive, highly effective, has no side effects, and is highly safe. This represents a major innovation in medicines for treating indigestion in infants and young children, indigestion in adults, and slow recovery of spleen and stomach function after surgery.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition that promotes gastrointestinal digestion, its preparation method, and its application. Background Technology

[0002] Indigestion is a common ailment in newborns and infants, primarily manifesting as abdominal distension, loss of appetite, vomiting of sour or rancid food, foul-smelling stools, and greasy, sticky stools. In severe cases, it can lead to irritability, night crying, and fever in infants, and may be accompanied by malnutrition and poor growth and development. Besides infants and young children, adults are also prone to indigestion, a condition known as adult food stagnation. This symptom is mainly caused by improper diet and overeating, manifesting as nausea, vomiting, acid reflux, abdominal distension, frequent bowel movements, and bad breath. Furthermore, postoperative patients often experience digestive problems due to weakened spleen and stomach function and poor digestive capacity. Currently, there are no universal medications specifically for treating indigestion in infants, adult food stagnation, or for improving digestive function in postoperative patients. Summary of the Invention

[0003] In view of this, the purpose of the present invention is to provide a traditional Chinese medicine composition, which is a compound of charred hawthorn, charred Shenqu, charred malt and Poria cocos, which has the effects of strengthening the spleen and stomach, promoting diuresis and removing dampness, and clearing the intestines and stomach. It is effective for treating indigestion in infants and young children, indigestion in adults and postoperative patients to regulate their digestive ability.

[0004] This invention provides a traditional Chinese medicine composition for promoting gastrointestinal digestion, comprising the following raw materials in parts by weight: 5-20 parts of charred hawthorn, 5-25 parts of charred Shenqu (medicated leaven), 5-20 parts of charred malt, and 5-20 parts of Poria cocos.

[0005] Preferably, the raw materials include the following parts by weight: 8-15 parts of charred hawthorn, 8-20 parts of charred Shenqu (medicated leaven), 8-15 parts of charred malt, and 8-15 parts of Poria cocos.

[0006] Preferably, the raw materials include the following parts by weight: 9-12 parts of charred hawthorn, 9-14 parts of charred Shenqu (medicated leaven), 9-12 parts of charred malt, and 9-12 parts of Poria cocos.

[0007] This invention provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps:

[0008] The raw materials of the traditional Chinese medicine composition are soaked in water and then decocted. The decoction is then separated to obtain the traditional Chinese medicine composition.

[0009] Preferably, the total mass of the raw materials in the traditional Chinese medicine composition and the volume ratio of water are 5-16 g: 100 mL.

[0010] Preferably, the soaking time is 20 to 40 minutes.

[0011] This invention provides a drug that promotes gastrointestinal digestion, wherein the active ingredient comprises the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method.

[0012] Preferably, the dosage form of the drug includes at least one of the following: decoction, pill, and granule.

[0013] This invention provides the application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in the preparation of drugs for regulating gastrointestinal digestion.

[0014] Preferably, the diseases for which gastrointestinal digestion is regulated include at least one of the following: indigestion in infants and young children, indigestion in adults, and digestive disorders in postoperative patients.

[0015] This invention provides a traditional Chinese medicine composition for promoting gastrointestinal digestion, comprising the following raw materials in parts by weight: 5-20 parts of charred hawthorn, 5-25 parts of charred medicated leaven, 5-20 parts of charred malt, and 5-20 parts of Poria cocos. In this traditional Chinese medicine composition, charred hawthorn eliminates food stagnation caused by meat, charred malt eliminates food stagnation caused by wheat-based foods, charred medicated leaven eliminates food stagnation caused by alcohol and stale food, and Poria cocos promotes diuresis and relieves intestinal obstruction. These four herbs strengthen the spleen and stomach, promote diuresis, and relieve intestinal obstruction. All the raw materials in this composition are medicinal and edible herbs, simple yet potent, combining the safety of food with the efficacy of medicine. This invention has good clinical efficacy in treating food stagnation in infants and young children, indigestion in adults, and slow recovery of spleen and stomach function after surgery. The formula is scientific, the combination is reasonable, the medicinal sources are abundant, the preparation process is simple, it is easy to carry, convenient to use, inexpensive, highly effective, has no side effects, and is highly safe. It can effectively alleviate the clinical symptoms of food stagnation in infants and young children, indigestion in adults, and slow recovery of spleen and stomach function after surgery. Detailed Implementation

[0016] This invention provides a traditional Chinese medicine composition for promoting gastrointestinal digestion, comprising the following raw materials in parts by weight: 5-20 parts of charred hawthorn, 5-25 parts of charred Shenqu (medicated leaven), 5-20 parts of charred malt, and 5-20 parts of Poria cocos.

[0017] In this invention, the traditional Chinese medicine composition preferably includes the following raw materials in parts by weight: 8-15 parts of charred hawthorn, 8-20 parts of charred Shenqu (medicated leaven), 8-15 parts of charred malt, and 8-15 parts of Poria cocos. More preferably, it includes the following raw materials in parts by weight: 9-12 parts of charred hawthorn, 9-14 parts of charred Shenqu, 9-12 parts of charred malt, and 9-12 parts of Poria cocos.

[0018] In this invention, the charred hawthorn eliminates the accumulation of meat, the charred malt eliminates the accumulation of wheat-based foods, the charred Shenqu eliminates the accumulation of stale and fermented foods, and the Poria cocos promotes diuresis and relieves intestinal discomfort. This invention does not have specific limitations on the source of the charred hawthorn, charred malt, and Poria cocos; commercially available charred hawthorn, charred malt, and Poria cocos from sources well-known in the art can be used. In an embodiment of this invention, the preferred method for preparing the charred Shenqu is to take 12 parts each of fresh Artemisia annua, fresh Xanthium sibiricum, and fresh Polygonum hydropiper, chop them, and take 6 parts each of ground red adzuki beans and ground almonds (peeled and ground). Mix them together, add 100 parts of wheat bran and 60 parts of wheat flour, add water and knead into a dough, then allow it to ferment naturally until yellow mycelium grows on the surface. Cut it into pieces and dry it in the sun. The charred Shenqu described here can more quickly activate the medicinal effect than ordinary charred Shenqu (commercially available).

[0019] In this invention, the charred hawthorn, charred Shenqu, charred malt, and Poria cocos are all traditional Chinese medicines that are both food and medicine, have good safety, and have a good conditioning effect on indigestion in infants and young children, indigestion in adults, and slow recovery of spleen and stomach function after surgery.

[0020] The present invention provides a method for preparing the traditional Chinese medicine composition, comprising the following steps: soaking the raw materials of the traditional Chinese medicine composition in water and then decocting them, separating the decoction, and obtaining the traditional Chinese medicine composition.

[0021] In this invention, the preferred volume ratio of the total mass of the raw materials to water in the herbal composition is 5-16 g:100 mL, more preferably 8-12 g:100 mL, and even more preferably 6-8 g:125 mL. The water is preferably distilled water or drinking water. The preferred soaking time is 20-40 min, more preferably 30 min. The preferred soaking temperature is 20-27°C, more preferably 25°C. The preferred decoction time is 40-60 min, more preferably 45-50 min. The preferred decoction temperature is to first decoct over high heat, then reduce to a simmer after boiling. The preferred method for separating the medicinal liquid is filtration.

[0022] This invention provides a drug that promotes gastrointestinal digestion, wherein the active ingredient comprises the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method.

[0023] In this invention, the dosage form of the drug preferably includes at least one of the following: decoction, pill, and granule. This invention does not impose any particular limitation on the preparation method of the drug; any preparation method of common traditional Chinese medicine dosage forms known to those skilled in the art can be used. In this embodiment of the invention, a decoction is used as the dosage form. The decoction preferably includes the traditional Chinese medicine composition prepared by the above method and a flavoring agent. The flavoring agent preferably includes sucrose. The preferred mass of sucrose added per milliliter of the traditional Chinese medicine composition is 3-4 g.

[0024] In this invention, the drug is administered 2-3 times daily. Infants and young children take 150 mL three times daily. Adults take 200 mL twice daily.

[0025] This invention provides the application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in the preparation of drugs for regulating gastrointestinal digestion.

[0026] In this invention, the diseases for which gastrointestinal digestion is regulated preferably include at least one of the following: indigestion in infants and young children, indigestion in adults, and digestive disorders in postoperative patients. Indigestion in infants and young children refers to food stagnation in newborns to children aged 7 years, with symptoms including vomiting, diarrhea, fever, halitosis, and lethargy. Indigestion in adults manifests as headache and vomiting after drinking alcohol, loss of appetite, a weak and hesitant pulse on the right side of the pulse, and a greasy tongue coating. Digestive disorders in postoperative patients include slow recovery of spleen and stomach function after surgery. Slow recovery of spleen and stomach function after surgery manifests as loss of appetite, vomiting, excessive phlegm, bloating, and acid reflux.

[0027] The following detailed description, in conjunction with embodiments, illustrates a traditional Chinese medicine composition for promoting gastrointestinal digestion, its preparation method, and its application, but these descriptions should not be construed as limiting the scope of protection of this invention.

[0028] Example 1

[0029] A method for preparing a traditional Chinese medicine composition for treating indigestion in infants and young children

[0030] Accurately weigh the following Chinese herbs: 5 grams of roasted malt, 5 grams of roasted hawthorn, 7 grams of roasted Shenqu (medicated leaven), and 5 grams of Poria cocos. Place them in a decoction bag, add 500 ml of water, soak for 0.5 hours, then decoct for 45 minutes. Remove the residue, filter out 60 ml of the decoction, add 2 g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0031] The preparation method of Jiao Shen Qu involves taking 12g each of fresh Artemisia annua, fresh Xanthium sibiricum, and fresh Polygonum hydropiper and chopping them. Also, take 6g each of powdered red adzuki beans and powdered almonds (after peeling and grinding them). Mix them together, add 100g of wheat bran and 60g of wheat flour, add water and knead into a dough. Cover with gauze and let it ferment naturally. When yellow mycelium grows on the surface, cut it into pieces and dry it in the sun.

[0032] Example 2

[0033] A method for preparing a traditional Chinese medicine composition for treating indigestion in adults

[0034] Accurately weigh the following Chinese herbs: 15g of roasted malt, 15g of roasted hawthorn, 17g of roasted Shenqu prepared in Example 1, and 15g of Poria cocos. Place them in a decoction bag, add 500ml of water and soak for half an hour. Then decoct for 45 minutes, remove the residue, filter the liquid to obtain 200ml of decoction, add 5g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0035] Example 3

[0036] A method for preparing a traditional Chinese medicine composition for slow recovery of spleen and stomach function after surgery.

[0037] Accurately weigh the following Chinese herbs: 20g of roasted malt, 20g of roasted hawthorn, 25g of roasted Shenqu prepared in Example 1, and 20g of Poria cocos. Place them in a decoction bag, add 500ml of water and soak for half an hour. Then decoct for 45 minutes, remove the residue, filter the liquid to obtain 150ml of decoction, add 5g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0038] Example 4

[0039] A method for preparing a traditional Chinese medicine composition for treating indigestion in adults

[0040] Accurately weigh the following Chinese herbs: 12g of roasted malt, 12g of roasted hawthorn, 15g of roasted Shenqu prepared in Example 1, and 12g of Poria cocos. Place them in a decoction bag, add 500ml of water and soak for half an hour. Then decoct for 45 minutes, remove the residue, filter the liquid to obtain 150ml of decoction, add 5g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0041] Example 5

[0042] A method for preparing a traditional Chinese medicine composition for treating indigestion in infants and young children

[0043] Accurately weigh the following Chinese herbs: 8 grams of roasted malt, 8 grams of roasted hawthorn, 10 grams of roasted Shenqu prepared in Example 1, and 8 grams of Poria cocos. Put them into a decoction bag, add 500 ml of water and soak for half an hour. Then decoct for 45 minutes, remove the residue, filter 100 ml of the decoction, add 3 g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0044] Example 6

[0045] A method for preparing a traditional Chinese medicine composition for treating indigestion in infants and young children

[0046] Accurately weigh the following Chinese herbs: 9 grams of roasted malt, 9 grams of roasted hawthorn, 12 grams of roasted Shenqu prepared in Example 1, and 9 grams of Poria cocos. Put them into a decoction bag, add 500 ml of water and soak for half an hour. Then decoct for 45 minutes, remove the residue, filter 100 ml of the decoction, add 3 g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0047] Example 7

[0048] Typical Case of Treating Indigestion in Children

[0049] The patient, a 6-month-old female, presented with vomiting and diarrhea. Her stools were watery, odorless, and frequent. She had a greasy tongue coating, indicating indigestion and food stagnation in the stomach, obstructing the spleen and stomach's function. The decoction prepared in Example 1 was poured into a bottle and fed to the infant twice a day, one packet each time, when she showed an appetite. The diarrhea subsided after the second feeding, and the vomiting returned to normal. The diarrhea also returned to normal the following day.

[0050] Example 8

[0051] Typical cases of adult indigestion after drinking alcohol

[0052] The patient, a 43-year-old male, reported experiencing headache and vomiting after excessive alcohol consumption two days prior. He continued to vomit upon waking the following day and had lost his appetite for two days. His right Guan pulse was deep and hesitant, and his tongue coating was slippery and greasy, indicating a diagnosis of indigestion due to alcohol consumption, leading to spleen and stomach weakness. He was prescribed the herbal decoction prepared in Example 2, three times a day, one packet each time. After two doses, he felt hungry again and was advised to eat light foods such as thin porridge to nourish his spleen and stomach.

[0053] Example 9

[0054] Typical case of slow recovery of spleen and stomach function after surgery

[0055] The patient, a 72-year-old male, is my father. He presented with a right renal cyst, hematuria, T4 stage, and had undergone surgical removal. He had no appetite for three days, vomiting even after drinking water, and had excessive phlegm. He had not had a bowel movement for five days and experienced intestinal distension. Enemas and other methods were ineffective. He took the traditional Chinese medicine decoction prepared in Example 3, twice a day, one packet each time. He had a bowel movement the following evening, his appetite returned, and blood tests showed his hemoglobin levels had increased. The attending physician advised discharge after one week.

[0056] Example 10

[0057] Typical cases of adult food poisoning

[0058] The patient, a 56-year-old female, reported that a week prior, she ate half a bowl of fried peanuts. Around 8 PM, she experienced chest pain followed by vomiting, accompanied by a tearing sensation in her chest. Afterward, she lost her appetite. Forcing herself to eat resulted in bloating, discomfort, and acid reflux. She underwent a gastroscopy, but no abnormalities were found. Her right anal sphincter was weak, and her tongue coating was white and greasy. She was prescribed the herbal decoction prepared in Example 4, twice a day, one 200mL packet each time. The next day, she regained her appetite, and the bloating, acid reflux, and discomfort disappeared. She was advised to continue the treatment for another 3 days to consolidate the effect. A follow-up two months later showed no recurrence.

[0059] Example 11

[0060] Typical Cases of Indigestion in Feverish Infants

[0061] The patient, a 4-year-old boy, presented to the clinic after conventional treatment at the hospital proved ineffective. Upon arrival, the infant was lethargic, had bad breath, fever, a thick, greasy tongue coating, and a high body temperature upon touch. He had no appetite for two days, only wanting to drink orange juice. His fever recurred after being treated with ibuprofen. Further questioning revealed that the symptoms appeared several days prior after eating biscuits. The diagnosis was food stagnation in the stomach, obstructing the spleen and stomach's digestive function, and weakening the middle jiao (middle burner). He was prescribed the herbal decoction prepared in Example 5, three times a day, one 150mL packet each time. His symptoms lessened after a bowel movement at 4 PM that day, and the fever subsided by 5 PM. He was instructed to continue the treatment for two more days to consolidate the effect. A follow-up two days later showed everything was normal.

[0062] Example 12

[0063] Typical Cases of Indigestion in Infants with Fever and Cough

[0064] The patient, a 6-year-old girl, presented with lethargy, halitosis, fever, persistent cough, thick, greasy tongue coating, and elevated body temperature upon touch. She had no appetite for two days, only wanting to drink water and eat small amounts of fruit. The fever recurred after treatment with ibuprofen. Further questioning revealed that these symptoms appeared several days prior after consuming ham sausage. The diagnosis was food stagnation in the stomach, obstructing the spleen and stomach's digestive function, leading to weakness in the middle jiao (middle burner). Heat in the stomach meridian was also observed, ascending to the lungs, causing the cough. She was prescribed the herbal decoction prepared in Example 6, three times a day, one 150mL packet each time. Her symptoms lessened after a bowel movement that evening, and the fever subsided. The cough also lessened the next day. She was instructed to continue the treatment for another three days to consolidate the effect. A follow-up three days later showed everything was normal.

[0065] Example 13

[0066] Sixty children aged 3-6 years presented with symptoms including constipation for several days, reduced appetite, and night crying in a few cases. The diagnosis was indigestion, with widespread symptoms of food stagnation. The decoction prepared in Example 1 was administered three times a day, one 200mL packet each time. The decoction effectively relieved the children's symptoms; they showed appetite within 2 hours and had a bowel movement within 6 hours. Other symptoms subsequently lessened, with an effectiveness rate of 100%. Parents reported that the decoction was the most effective treatment compared to similar medications purchased from pharmacies (domperidone, mosapride, pepsin, compound digestive enzymes, gastrin, teprenone), without causing additional acid reflux, belching, or heartburn.

[0067] Comparative Example 1

[0068] To compare the efficacy of the traditional Chinese medicine decoction prepared in Example 1 and Jiangzhong Jianwei Xiaoshi tablets, 10 children (5-8 years old) with symptoms of food stagnation were randomly divided into two groups. One group was given Jiangzhong Jianwei Xiaoshi tablets, and the method of administration was as per the instructions. The other group was given the traditional Chinese medicine decoction prepared in Example 1, which was taken 3 times a day, one packet each time, with each packet containing 150 mL.

[0069] The results showed that children who took the herbal decoction in Example 1 had bowel movements within 2 hours, reported feeling hungry and having a desire to eat, and did not experience stomach acid or heartburn. However, only 2 children who took Jiangzhong Jianwei Xiaoshi tablets had bowel movements 2 hours after taking the medication, and other symptoms were not significantly relieved.

[0070] Comparative Example 2

[0071] To compare the efficacy of the traditional Chinese medicine decoction prepared in Example 2 and the Siwei Piwei Shu granules, 10 adults (20-30 years old) with symptoms of food stagnation were randomly divided into two groups. One group was given Siwei Piwei Shu granules, and the method of administration was as per the instructions. The other group was given the traditional Chinese medicine decoction prepared in Example 2, which was taken twice a day, one sachet each time, with each sachet containing 200 mL.

[0072] The results showed that adults who took the herbal decoction in Example 2 reported feeling hungry and having a desire to eat 2 hours after taking the medicine, without experiencing stomach acid or heartburn. However, only two adults experienced symptom relief after taking the Siwei Piwei Shu granules.

[0073] Comparative Example 3

[0074] A method for preparing a traditional Chinese medicine composition for treating indigestion in adults

[0075] Accurately weigh the following Chinese herbs: 15g roasted malt, 15g roasted hawthorn, 17g ordinary roasted Shenqu (commercially available), and 15g Poria cocos. Place them in a decoction bag, add 500ml of water and soak for half an hour. Then decoct for 45 minutes, remove the residue, filter the liquid to 200ml, add 5g of sucrose and dissolve to obtain the Chinese herbal decoction.

[0076] Comparative Example 4

[0077] Ten adults (30-40 years old) with symptoms of food stagnation were randomly divided into two groups. One group was given the traditional Chinese medicine decoction prepared in Example 4, and the other group was given the traditional Chinese medicine decoction prepared in Example 2. Both groups took the medicine twice a day, one 200mL packet each time.

[0078] The results showed that adults who took the herbal decoction in Example 2 reported that their gastrointestinal tract was clear, their feeling of fullness disappeared, and they experienced hunger and a desire to eat 2 hours after taking the decoction. In contrast, the symptoms of clear gastrointestinal tract, loss of fullness, hunger, and a desire to eat only appeared 4 hours after taking the herbal decoction prepared in Comparative Example 4.

[0079] As can be seen from the results of the above embodiments, the present invention, which combines roasted malt, roasted hawthorn, roasted Shenqu (a type of fermented wheat), and Poria cocos, can effectively treat indigestion in infants and young children, indigestion in adults, and digestive disorders in postoperative patients, and its effect is superior to conventional stomach-strengthening and digestive-aiding traditional Chinese medicines.

[0080] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for promoting gastrointestinal digestion, characterized in that, The ingredients include the following parts by weight: 5-20 parts charred hawthorn, 5-25 parts charred Shenqu (medicated leaven), 5-20 parts charred malt, and 5-20 parts Poria cocos.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The ingredients include the following parts by weight: 8-15 parts charred hawthorn, 8-20 parts charred Shenqu (medicated leaven), 8-15 parts charred malt, and 8-15 parts Poria cocos.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The ingredients include the following parts by weight: 9-12 parts charred hawthorn, 9-14 parts charred Shenqu (medicated leaven), 9-12 parts charred malt, and 9-12 parts Poria cocos.

4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: The raw materials of the traditional Chinese medicine composition are soaked in water and then decocted. The decoction is then separated to obtain the traditional Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that, The total mass of the raw materials in the traditional Chinese medicine composition and the volume ratio of water are 5-16g:100mL.

6. The preparation method according to claim 4, characterized in that, The soaking time is 20 to 40 minutes.

7. A drug for promoting gastrointestinal digestion, characterized in that, The active ingredients include the traditional Chinese medicine composition according to any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the preparation method according to claim 4 or 5.

8. The drug according to claim 7, characterized in that, The dosage form of the drug includes at least one of the following: decoction, pill, and granule.

9. The use of the traditional Chinese medicine composition according to any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the preparation method according to claim 4 or 5 in the preparation of a drug for regulating gastrointestinal digestion.

10. The application according to claim 9, characterized in that, The diseases for which gastrointestinal digestion is regulated include at least one of the following: indigestion in infants and young children, indigestion in adults, and digestive disorders in postoperative patients.