Synergistic anti-corrosion blends and compositions containing such blends

Abstract

This application provides preservative compositions of pyrithione compounds, organic acids or their salts, and aromatic alcohols, which have a synergistic effect and can reduce the amount of pyrithione required as an effective preservative in end-use formulations.

Description

[0001] background

[0002] Microbial contamination of personal care products, home care products, and other similar products is a critical concern in the industry and can be a major cause of product loss. Preservatives and preservative compositions are known in the art for protecting and preserving end-use formulations from microbial attack by bacteria or fungi. These preservatives and preservative compositions have wide applications in personal care products, cosmetics, home care products, and health and hygiene products. Conventional preservatives and preservative compositions use traditional active ingredients such as benzisothiazolinone, methylisothiazolinone, and methylchloroisothiazolinone, which provide good bactericidal and fungicidal properties against microbial attack. However, due to increasingly stringent government regulations on the use of benzisothiazolinone, methylisothiazolinone, and methylchloroisothiazolinone, there is a need for equally cost-effective and broad-spectrum alternative preservative compositions.

[0003] One problem with antimicrobial agents (such as pyrithione) is that they typically require high concentrations in preservative compositions to be effective. Because such high concentrations are known to be required, the use of pyrithione in personal care and home care products can be prohibitively expensive.

[0004] Ideally, a suitable preservative or preservative composition should exhibit broad-spectrum activity against all types of microorganisms at various pH values. The preservative or preservative composition should also be highly effective so that costs can be saved by using minimal amounts of preservative and any potential adverse effects caused by one or more preservatives in the composition are avoided or reduced. Furthermore, it is ideal that the preservative or preservative composition is stable to any temperature variations encountered during manufacturing, packaging, and transportation, as well as during storage of the end-use formulation in which it is placed. Additionally, the ideal preservative is physically and chemically compatible with the components present in various end-use formulations so that a single preservative or preservative composition can be appropriately incorporated into a variety of products.

[0005] Recent developments in preservative technology have focused on identifying compounds that synergistically interact with preservatives to enhance their efficacy and / or effectively reduce the amount of preservative required to achieve the desired preservative effect. This is due to ongoing regulatory pressure to reduce the amount of preservatives used in end-use formulations.

[0006] Similarly, in the field of personal care formulations containing active ingredients for treating specific conditions (such as dandruff), regulatory pressure is mounting to reduce the amount of active ingredients used in personal care formulations. One way to reduce the amount of active ingredients is to enhance their efficacy in personal care formulations, creating synergistic mixtures of active ingredients and synergists, which enhance the efficacy of the active ingredients.

[0007] This disclosure addresses this need by providing a preservative composition comprising a synergistic mixture of a pyrithione compound, an organic acid or its salt thereof, and an aromatic alcohol, which can be used as a preservative in various compositions, including personal care or household care formulations. Summary of the Invention

[0008] On the one hand, a preservative composition is provided comprising (i) a pyrithione compound; (ii) an organic acid or a salt thereof; and (iii) an aromatic alcohol, wherein the preservative composition exhibits a synergistic effect; and wherein the weight ratio of the pyrithione compound, the organic acid or a salt thereof, and the aromatic alcohol is from about 1:1:1 to about 1:15630:12500.

[0009] On the other hand, an antiseptic composition is provided, wherein the weight ratio of the pyrithione compound, the organic acid or its salt to the aromatic alcohol is from about 1:1:1 to about 1:15630:12500, for example from about 1:1:1 to about 1:10000:10000, for example from about 1:1:1 to about 1:5000:5000.

[0010] The pyrithione compounds may include water-soluble pyrithiones. In a specific embodiment, the water-soluble pyrithione includes sodium 1-oxo-2-mercaptopyridine.

[0011] In one specific aspect, the aromatic alcohol comprises phenoxyethanol. In an alternative embodiment, the aromatic alcohol comprises benzyl alcohol.

[0012] In one embodiment of this disclosure, the organic acid or a salt thereof comprises itaconic acid. In another embodiment, the organic acid or a salt thereof comprises lactic acid, levulinic acid, citric acid, or mixtures thereof.

[0013] In one specific aspect, the pyrithione compound comprises sodium 1-oxo-2-mercaptopyridine, the aromatic alcohol comprises phenoxyethanol, and the organic acid or its salt comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate.

[0014] On the other hand, the pyrithione comprises sodium 1-oxo-2-mercaptopyridine, the aromatic alcohol comprises benzyl alcohol, and the organic acid or its salt comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate.

[0015] In another aspect of this disclosure, personal care or home care compositions are provided, comprising a base composition and a preservative composition as described in the prior embodiments.

[0016] In another aspect of this disclosure, the personal care or home care composition comprises a pyrithione compound. The pyrithione compound is present in the base composition at a concentration of less than about 1000 ppm, for example, less than about 500 ppm, for example, less than about 250 ppm, for example, less than about 100 ppm, for example, less than about 50 ppm.

[0017] In another aspect of this disclosure, the personal care or home care composition further comprises an organic acid or a salt thereof and an aromatic alcohol. In a specific embodiment, the weight ratio of the pyrithione compound to the organic acid or a salt thereof and to the aromatic alcohol in the personal care or home care composition is from about 1:11:12500 to about 1:15630:12500, for example from about 1:1:1 to 1:10000:10000, for example from about 1:1:1 to about 1:5000:5000.

[0018] In another embodiment, the personal care or home care composition comprises a liquid, a semi-solid, or a solid.

[0019] In a specific implementation, the personal care or home care composition includes color-enhancing cosmetic products, deodorizing products, hair care products, oral care products, skin care products, or bath products.

[0020] In another embodiment, the personal care or household care composition comprises hand-washing dish soap, machine-washing dish soap, machine-washing dish rinse aid, laundry detergent, laundry fabric conditioner, fabric fragrance and / or wrinkle treatment agent, ironing aid, cleaning wipes, general-purpose cleaner, and other similar formulations for use around the home. In one embodiment, the household care product is a cleaning product selected from the group consisting of: hand-washing dish soap, laundry detergent, cleaning wipes, and general-purpose cleaners, such as floor, countertop, kitchen, carpet, bathroom, and toilet cleaners.

[0021] In embodiments of this disclosure, the personal care or home care composition comprises a pre-moistened wipe.

[0022] In another embodiment, the base composition of the personal or home care composition comprises at least one of a solvent, surfactant, complexing agent, corrosion inhibitor, alkalinity enhancer, pH adjuster, adjuvant, acid, foaming agent, fragrance, colorant, humectant, emulsifier, thickener, antioxidant, UV blocker, wax, natural extract or oil.

[0023] In embodiments of this disclosure, a method is provided to improve the efficacy of a preservative in an end-use formulation. The method includes adding a blend of the preservatives described in previous embodiments to the end-use formulation.

[0024] These and other aspects will become apparent when reading the detailed description of the invention.

[0025] Detailed description

[0026] Those skilled in the art will understand that this discussion is merely a description of exemplary embodiments and is not intended to limit the broader aspects of this disclosure.

[0027] Generally, this disclosure relates to a preservative composition. As used in this application, the term "preservative" means a biocide or biocide composition intended to be incorporated into an end-use formulation (e.g., personal care formulations, cosmetics, household care formulations, and health and hygiene products) to prevent microbial degradation of the end-use formulation or to render the end-use formulation unusable for the specific purpose for which it was developed.

[0028] It has been unexpectedly discovered that the combination of pyrithione compounds, organic acids or their salts, and aromatic alcohols in preservative compositions produces a synergistic effect and can be incorporated into end-use formulations at extremely low levels while providing excellent antimicrobial properties. As used in this application, "synergistic interaction" means that the total antimicrobial / antifungal effect of the combination of pyrithione, organic acids or their salts, and aromatic alcohols is greater than the antimicrobial / antifungal effect of the combination of organic acids or their salts and aromatic alcohols alone. In other words, the pyrithione compounds of this disclosure synergize with organic acids or their salts and aromatic alcohols such that, in their presence, the antimicrobial / antifungal activity against certain microorganisms is greater than the antimicrobial activity of using pyrithione compounds alone or the antimicrobial activity of the combination of organic acids or their salts and aromatic alcohols at the same concentration. Due to this synergistic effect, the content of pyrithione in the preservative composition can be reduced while still producing the desired efficacy. This effect is also referred to as the "enhancing effect" of pyrithione in the preservative composition. In this application, this enhancing effect of pyrithione is also referred to as the "synergistic effect" between pyrithione and the combination of organic acids or their salts, and aromatic alcohols, for improving the efficacy of pyrithione.

[0029] As used in this application, the term "its salt" is intended to include cations of sodium, potassium, calcium, magnesium, ammonium, and ethanolamine, as well as other similar cations, and anions of chloride, bromide, acetate, sulfate, as well as other similar anions.

[0030] The preservative composition disclosed in this application comprises (i) a pyrithione compound; (ii) an organic acid or a salt thereof; and (iii) an aromatic alcohol. The weight ratio of the pyrithione compound to the organic acid or a salt thereof and the aromatic alcohol is from about 1:1:1 to about 1:15630:12500, for example from about 1:1:1 to about 1:10000:10000, for example from about 1:1:1 to about 1:5000:5000.

[0031] Pyrithione compounds are preservatives known as iron chelating agents. Pyrithiones have several names, including 2-mercaptopyridine-N-oxide; 2-pyridinethiol-1-oxide (CAS Registry No. 1 121-31-9); 1-hydroxypyridine-2-thione and 1-hydroxy-2(1H)-pyridinethione (CAS Registry No. 1 121-30-8); 2-pyridinephenol-1-oxide (HPNO); and N-hydroxy-6-octoxypyridine-2(1H)-one and 1-hydroxy-6-octoxypyridine-2(1H)-one ethanolamine salts. Pyrithione salts are commercially available from Arxada AG, such as OMADINE® sodium or OMADINE® zinc.

[0032] Pyrithione compounds, which exist as preservatives, can be in water-insoluble or water-soluble forms. Exemplary pyrithione compounds include, for example, sodium 1-oxo-2-mercaptopyridine, zinc 1-oxo-2-mercaptopyridine, barium 1-oxo-2-mercaptopyridine, strontium 1-oxo-2-mercaptopyridine, copper 1-oxo-2-mercaptopyridine, cadmium 1-oxo-2-mercaptopyridine, and / or zirconium 1-oxo-2-mercaptopyridine. Other pyrithione compounds that may be present in the composition include sodium 1-oxo-2-mercaptopyridine, bismuth 1-oxo-2-mercaptopyridine, potassium 1-oxo-2-mercaptopyridine, lithium 1-oxo-2-mercaptopyridine, ammonium 1-oxo-2-mercaptopyridine, calcium 1-oxo-2-mercaptopyridine, magnesium 1-oxo-2-mercaptopyridine, silver 1-oxo-2-mercaptopyridine, gold 1-oxo-2-mercaptopyridine, manganese 1-oxo-2-mercaptopyridine, and / or organic amine pyrithione. In a preferred embodiment, the pyrithione compound is sodium 1-oxo-2-mercaptopyridine. A single pyrithione compound may be present as a preservative, or any combination of the above-mentioned pyrithione compounds may be included as a preservative.

[0033] Pyrithione compounds can have particle sizes such that 100% of the particles are smaller than about 10 micrometers, at least 70% are smaller than 5 micrometers, and for example, at least about 50% can have a particle size of 1 micrometer or smaller. Particle size can be measured using a laser scattering particle size analyzer, such as the HORIBA LA 910 particle size analyzer.

[0034] Pyrithione-based compound particles can be prepared by reacting pyrithione or its water-soluble salts with water-soluble polyvalent metal salts in a pressurized turbulent reactor that generates a pulverizing force. The pulverizing force generated by the pressurized turbulent reactor efficiently produces micron-sized pyrithione salt particles. The micron-sized pyrithione salt particles prepared by this method have a narrow and uniform particle size distribution and excellent surface deposition properties due to the large surface area provided by the micron-particle population.

[0035] The amount of the pyrithione compound in the end-use preservative composition formulation may be up to about 1% by weight, for example up to about 0.75% by weight, for example up to about 0.50% by weight, for example up to about 0.25% by weight, depending on the use of the end-use preservative composition.

[0036] Pyrithione may also have other advantages in end-use preservative compositions, including anti-dandruff properties in hair care products.

[0037] The preservative composition further comprises an organic acid or a salt thereof. Exemplary organic acids include, for example, lactic acid, levulinic acid, citric acid, itaconic acid, carboxylic acids, hydroxy acids, succinic acid, methanesulfonic acid, phytic acid, phosphonoacetic acid, N-(phosphonomethyl)iminodiacetic acid, diethylenetriaminepenta(methylphosphonic acid), S,S-ethylenediamine-N'N'-disuccinic acid, or any mixture thereof. Exemplary salts include, for example, sodium benzoate and potassium sorbate. Other salts may also be used. In a preferred embodiment, the organic acid is lactic acid, levulinic acid, citric acid, or itaconic acid, their salts, or any mixture thereof. In another embodiment, the organic acid is itaconic acid. In an alternative embodiment, the organic acid comprises lactic acid, levulinic acid, citric acid, or a mixture thereof.

[0038] The preservative composition may contain about 1% to about 5% by weight of an organic acid, such as citric acid, succinic acid, phosphoric acid, lactic acid, or any mixture thereof. In another embodiment, the composition may contain about 1% to about 5% by weight of an organic acid, such as citric acid, succinic acid, phosphoric acid, lactic acid, or any mixture thereof, combined with about 0.05% to about 5% by weight of another organic acid. In yet another embodiment, the composition may contain about 2% to about 4% by weight of an organic acid, such as citric acid, succinic acid, phosphoric acid, lactic acid, or any mixture thereof, combined with about 0.1% to about 4% by weight of another organic acid.

[0039] Organic acid compounds can be present as preservatives in end-use preservative formulations at concentrations up to about 3% by weight, depending on the specific organic acid compound. Salts can also be used in similar amounts. In most cases, the acid or its salt is used at concentrations up to about 1% by weight, more typically up to about 0.6% by weight. Mixtures of organic acids can also be used in preservative compositions.

[0040] The preservative composition further comprises an aromatic alcohol. Exemplary aromatic alcohols include, for example, phenoxyethanol, 2,4-dichlorophenylmethanol, benzyl alcohol, 1-phenoxypropanol, chlorophenylglycerol ether, and benzyl hemiacetal. In a preferred embodiment, the aromatic alcohol is phenoxyethanol, benzyl alcohol, or a mixture thereof.

[0041] Depending on the specific alcohol compound, the content of aromatic alcohols in the end-use formulation can be as high as about 1.5% by weight, based on the total weight of the end-use formulation. In most cases, the amount of said alcohol compound is typically as high as about 1% by weight, and more typically as high as about 0.5% by weight, based on the weight of the end-use formulation.

[0042] In one embodiment of the preservative composition, the pyrithione compound comprises sodium 1-oxo-2-mercaptopyridine, the aromatic alcohol comprises phenoxyethanol, and the organic acid or a salt thereof comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate. In an alternative embodiment of the preservative composition, the pyrithione compound comprises sodium 1-oxo-2-mercaptopyridine, the aromatic alcohol comprises benzyl alcohol, and the organic acid or a salt thereof comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate.

[0043] It will be understood that the preservative compositions disclosed herein are not limited to containing only pyrithione, organic acids or their salts, and aromatic alcohols. Other preservatives may also be used in the preservative compositions. Suitable preservatives available in this disclosure include, for example, acids, esters and their salts, aldehydes, phenolic compounds, sulfites and iron chelating agents, quaternary ammonium compounds, aldehydes, pyranone compounds, urea compounds, imidazole compounds, isothiazolinones, and combinations thereof.

[0044] The preservative may be formulated as a preservative concentrate. "Preservative concentrate" or "preservative composition" refers to a composition to be added in a specific amount to an end-use formulation. In the preservative concentrate, the preservative content will be higher than the typical end-use amount. The preservative concentrate may contain only the pyrithione compound, an organic acid or its salt, and an aromatic alcohol. Alternatively, the preservative concentrate may contain the pyrithione compound, an organic acid or its salt, an aromatic alcohol, and a carrier compatible with the end-use formulation. Exemplary carriers include, for example, aqueous solvents such as water, or other solvents acceptable for use in end-use formulations and those used in those formulations. Typically, the solvent may be a water-miscible solvent, such as an alcohol and / or an ethylene glycol ether. Examples of water-miscible solvents include ethanol, propanol, benzyl alcohol, isopropanol, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol monon-butyl ether, diethylene glycol dimethyl ether, ethylene glycol diethyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, dipropylene glycol methyl ether, dipropylene glycol butyl ether, and combinations thereof.

[0045] Typically, preservative concentrates are added to end-use formulations in the amount necessary to achieve the desired amount of preservative in the final end-use formulation.

[0046] In other embodiments, the pyrithione compound, the organic acid or its salt, and the aromatic alcohol may be added to the end-use formulation independently of each other. That is, the organic acid or its salt and the aromatic alcohol may be added to the end-use formulation before the addition of the pyrithione compound, after the addition of the pyrithione compound to the end-use formulation, or as separate components simultaneously with the pyrithione compound.

[0047] According to this disclosure, various microorganisms can be controlled. For example, the preservative composition of this disclosure can control Gram-positive bacteria, Gram-negative bacteria, etc. In addition to bacteria, the preservative composition of this disclosure can also kill various other microorganisms and control their growth, such as viruses, spores, mycobacteria, etc. Examples of specific microorganisms that can be controlled according to this disclosure include Staphylococcus aureus (…). Staphylococcus aureus Streptococcus pneumoniae () Streptococcus pneumonia ), Pseudomonas aeruginosa ( Pseudomonas aeruginosa Serratia marcescens ( ), Serratia decaying Salmonella enteritidis ( ) Salmonella enteritidis ), Neisseria gonorrhoeae ( Neisseria gonorrhea ), Escherichia coli ( Escherichia coli ), Enterococcus seais ( Enterococcus hirae Acinetobacter baumannii ( Acinetobacter baumannii Listeria monocytogenes ( ) Listeria monocytogenes Enterobacter glomerulonephritis ( Enterobacter gergoviae ), Klebsiella pneumoniae ( Klebsiella pneumoniae Burkholderia cepacia (), Burholderia cepacia ), Pseudomonas putida ( Pseudomonas putida ), Rhizotrophic coccidia ( Kocuria rhizophila Candida albicans ( Candida albicans ), brewer's yeast ( Saccharomyces yeast Aspergillus brasiliensis ( ) Aspergillus brasiliensis ), Penicillium cordiformis ( Penicillium rope-like ), Levitum penicillium ( Eupenicillium levitum ), Bacillus cereus ( Bacillus candle Bacillus subtilis ( Bacillus subtilis Clostridium difficile ( Clostridium difficile Clostridium perfringens ( ) Clostridium perfringens ), Mycobacterium tuberculosis ( Mycobacterium tuberculosis Mycobacterium tumefaciens ( ) Mycobacterium terrae ), Mycobacterium avium ( Mycobacterium avium ), poliovirus, adenovirus, norovirus, vaccinia virus, influenza virus, hepatitis B virus, human immunodeficiency virus, human papillomavirus or mixtures thereof.

[0048] Generally, the preservative compositions disclosed herein can be incorporated into many different end-use formulations or end-use products. As used in this application, "end-use formulation" or "end-use product" is intended to refer to personal care or home care products.

[0049] Personal care or home care product formulations typically comprise a base composition to which the preservative composition of this disclosure is added. The base composition may contain a variety of different ingredients depending on the end-use application. For example, personal care or home care product formulations may contain other solvents, surfactants, emulsifiers, complexing agents, corrosion inhibitors, alkalinity enhancers, pH adjusters, adjuvants, acids, foaming agents, colorants, UV blockers, waxes, natural extracts, oils, viscosity factors, conditioning agents, emollients, skin care ingredients, moisturizers, thickeners, humectants, fillers, antioxidants, other preservatives, active ingredients (especially dermatologically active ingredients), fragrances, etc., and mixtures thereof. The active ingredients described in this application include, for example, pharmaceutical agents such as anti-inflammatory agents, antibacterial agents, and antifungal agents. Active ingredients suitable for topical application are particularly preferred.

[0050] Surfactants suitable for the base composition include: alkyl sulfates, such as sodium lauryl sulfate and ammonium lauryl sulfate; sodium cetearyl sulfate; alkyl sulfonate salts, such as sodium lauryl sulfonate; alkyl ether sulfates, such as sodium laureth sulfate, sodium tridecyl ether sulfate, sodium oleyl ether sulfate, and ammonium lauryl ether sulfate; alkyl ether sulfosuccinate salts, such as disodium lauryl ether sulfosuccinate; and alkyl glycosides, such as decyl glucoside and lauryl... Glucosides; alkyl hydroxyethyl sulfonate amphoteric surfactants, such as cocamidopropyl betaine, sodium cocamidopropyl acetate, sodium lauroyl amphoteric acetate, disodium lauroyl diacetate, disodium cocamidopropyl acetate, sodium lauroyl amphoteric propionate, disodium lauroyl dipropionate; potassium or ammonium salts of the above amphoteric surfactants; octanoyl / decanoyl betaine, undecanoyl betaine, lauroyl amphoteric betaine; and fatty alcohol polyethylene glycol ethers.

[0051] Emulsifiers suitable for the base composition include, for example, anionic emulsifiers such as fatty acid salts (e.g., sodium stearate or sodium palmitate), organic soaps (e.g., mono-, di-, or triethanolamine soaps), sulfated or sulfonated compounds (e.g., sodium dodecyl sulfate or sodium hexadecyl sulfonate), saponins, lanolin acid soaps; cationic emulsifiers such as quaternary ammonium salts; nonionic emulsifiers such as fatty alcohols, fatty acid esters of saturated or unsaturated fatty acids, polyoxyethylene esters or polyoxyethylene ethers of fatty acids, polymers of ethylene oxide with propylene oxide or propylene glycol; amphoteric emulsifiers such as phospholipids, proteins (e.g., gelatin, casein), alkyl amide betaine, alkyl betaine and amphoteric glycinate salts, alkyl phosphates, alkyl polyoxyethylene phosphates or corresponding acids; and silicone derivatives such as alkyl dimethylsiloxane copolyols.

[0052] Suitable consistency factors for the base composition include, for example, fatty alcohols or mixtures thereof with fatty acid esters, such as acetylated lanolin alcohol, aluminum stearate, carbomer, cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl stearate (and) PEG100 stearate, magnesium stearate, magnesium sulfate, oleic acid, stearic acid, stearyl alcohol, myristyl myristate, isopropyl palmitate, carnauba wax, beeswax and its synthetic equivalents, carbomer, etc. Suitable conditioning agents include, for example, alkylamide ammonium lactate, hexadecyltrimethylammonium chloride, distearate ethyl hydroxyethyl methyl ammonium sulfate and cetearyl alcohol, cetyl polydimethylsiloxane, castor oil hexadecyl ester, polydimethylsiloxane, lauryl ether-23, lauryl ether-4, polydecene, retinyl palmitate, quaternized protein hydrolysates, quaternized cellulose and starch derivatives, quaternized copolymers or salts of acrylic acid or methacrylic acid, and quaternized siloxane derivatives.

[0053] Emollients suitable for base compositions include, for example, cetearyl isononanoate, cetearyl caprylate, decyl oleate, isooctyl stearate, cocoyl caprylate / decyl oleate, ethylhexyl hydroxystearate, ethylhexyl isononanoate, isopropyl isostearate, isopropyl myristate, oleate, hexyl laurate, liquid paraffin, PEG-75 lanolin, PEG-7 glyceryl cocoate, petrolatum, cyclomethicone, dimethicone, dimethicone copolyol, dioctyl ether, shea butter, boxwood, rapeseed oil, carnauba wax, carnauba wax palm, evening primrose, oil palm, sweet almond, squalane, corn, soybean, sunflower, lanolin, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated polyisobutylene, sucrose cocoate, stearoxy dimethicone, lanolin alcohol, and isohexadecane.

[0054] Skincare ingredients suitable for base compositions include plant extracts, bisabolol, anti-inflammatory agents, urea, allantoin, panthenol and panthenol derivatives, phytanetriol, vitamin A, vitamin E, vitamin C, vitamin D, ceramides from animal or plant sources, lecithin, etc.

[0055] Moisturizers suitable for the base composition include, for example, butylene glycol, cetyl alcohol, dimethicone, dimyristyl tartrate, glucosyl glycerin polyoxyethylene ether-26, glycerin, glyceryl stearate, hydrolyzed milk protein, lactic acid, lactose and other sugars, lauryl polyoxyethylene ether-8, lecithin, octyloxyglycerin, PEG-12, PEG-135, PEG-150, PEG-20, PEG-8, pentylene glycol, hexanediol, phytanetriol, polyquaternium-39, PPG-20 methyl glucosyl ether, propylene glycol, sodium hyaluronate, sodium lactate, sodium PCA, sorbitol, succinosaccharide, synthetic beeswax, tri-C14-15 alkyl citrate, and starch.

[0056] Thickeners suitable for the base composition include, for example, acrylate / stearyl polyoxyethylene ether-20 methacrylate copolymer, carbomer, carboxymethyl starch, white beeswax, polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, propylene glycol alginate, hydroxyethyl cellulose, hydroxypropyl methylcellulose, silica, dimethyl silylated silica, xanthan gum, and hydrogenated butene / ethylene / styrene copolymer.

[0057] Moisturizers suitable for the base composition include, for example, adipic acid, fumaric acid and its salts, benzoic acid and its salts, triacetin, sodium lauryl sulfate or magnesium lauryl sulfate, magnesium stearate, solid polyethylene glycol, polyvinylpyrrolidone, boric acid, monolaurate or monopalmitate, myristic acid, cetyl alcohol, cetearyl alcohol, talc, calcium or magnesium salts of higher fatty acids, monoglycerides of higher fatty acids, diglycerides of higher fatty acids or triglycerides of higher fatty acids, and polytetrafluoroethylene.

[0058] Antioxidants suitable for base compositions include sulfites (such as sodium sulfite), tocopherol or its derivatives, ascorbic acid or its derivatives, citric acid, propyl gallate, glycolic acid chitosan, cysteine, N-acetylcysteine ​​with zinc sulfate, thiosulfates (such as sodium thiosulfate), polyphenols, etc.

[0059] The formulation may further contain active ingredients, such as antimicrobial agents, anti-inflammatory agents, plant extracts, bisabolol, panthenol, tocopherol, active ingredients for anti-irritation, anti-dandruff applications, or anti-aging agents such as retinol, melibiose, etc. Other suitable active ingredients include: medicinal alfalfa (Medicago officinalis), Chinese kiwifruit (Actinidia chinensis), allantoin, Aloe barbadensis, Anonacherimolia, Roman chamomile (Anthemis nobilis), peanut (Arachis hypogaea), arnica (Arnica Montana), oat (Avena sativa), beta-carotene, bisabolol, borage (Borago officinalis), butylene glycol, calendula officinalis, camellia (Camellia sinensis), camphor, Candida bombicola, capryloyl glycine, papaya (Carica papaya), cornflower (Centaurea cyanus), hexadecylpyridinium chloride, chamomile (Chamomilla recutita), quinoa (Chenopodium quinoa), and red cinchona (Chinchona). Succirubra, Chondrus crispus, Citrus aurantium dulcis, Citrus grandis, Citrus limonum, Coconut (Cocos nucifera), Coffea Arabica, Crataegus monogina, Cucumis melo, Dichlorophenylimidazolium dioxolane, Enteromorpha compressa, Equisetum arvense, Ethoxydiethylene glycol, Ethyl panthenol, Farnesol, Ferulic acid, Fragaria chiloensis, Gentiana lutea, Ginkgo biloba, Glycerin, Glyceryl laurate, Glycyrrhiza glabra, Hamamelis virginiana, Piperaldehyde, Hydrogenated palm oil glycerides glycerides, citrates / esters, hydrolyzed castor oil, hydrolyzed wheat proteinprotein), Hypericumperforatum, Iris florentina, Juniperus communis, milk protein, lactose, Lawsonia inermis, linalool, Linum usitatissimum, lysine, magnesium aspartate, Magnifera indica, Malva sylvestris, mannitol, Melaleuca alternifolia, Mentha piperita, menthol, menthyl lactate, Mimosa tenuiflora, Nymphaea alba), olaflur, Oryzasativa, panthenol, liquid paraffin, polyethylene glycol-20M, PEG-26 jojoba acid, PEG-26 jojoba alcohol, PEG-35 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-8 caprylic / capric acid, avocado (Persea gratissima), petrolatum, potassium aspartate, potassium sorbate, propylene glycol, sweet almond (Prunus amygdalus dulcis), apricot (Prunus armeniaca), peach (Prunus persica), retinyl palmitate, castor bean (Ricinus communis), canine rose (Rosa canina), rosemary (Rosmarinus officinalis), raspberry (Rubusidaeus), salicylic acid, elderberry (Sambucus nigra), sarcosine, serenoa (Serenoa) Serrulata, Simmondsia chinensis, sodium carboxymethyl β-glucan, sodium cocoyl amino acid, sodium hyaluronate, sodium palmitoyl proline, stearoxytrimethylsilane, stearyl alcohol, sulfurized TEA-ricinoleate, talc, thyme (Thymus vulgaris), Tilia cordata, tocopherol, tocopheryl acetate, tridecyl polyoxyethylene ether-9, wheat (Triticum vulgare), tyrosine, undecenoyl glycine, urea, blueberry (Vaccinium myrtillus), valine, zinc oxide, zinc sulfate.

[0060] The base ingredients of personal care or home care products incorporating the preservative compositions disclosed herein can be of various types.

[0061] For example, personal care products may include tinted cosmetic products, deodorant products, hair care products, oral care products, skin care products, and bath products. Personal care product formulations may include any product intended for topical application to a user's skin or hair. When combined as a preservative with a personal care product formulation, the preservative compositions of this disclosure exhibit effective broad-spectrum preservative activity over a wide pH range. For example, the pH of the compositions and / or personal care products is generally greater than about 2 and less than about 10, such as about 3 to about 8, particularly about 3 to about 6.

[0062] Color-adding makeup products may include, but are not limited to, body color-adding products, eye makeup (such as mascara, eyeliner, eyebrow makeup and eyeshadow), face makeup (such as blush, bronzer, concealer, foundation, loose powder and primer), lip makeup (such as lipstick and lip balm) and nail products.

[0063] In one aspect, the eye makeup is mascara. The mascara may contain the preservative composition disclosed herein, water, a viscosity modifier, pigments, emollients, thickeners, and film-forming agents. Particularly suitable viscosity modifiers used in mascara include beeswax and carnauba wax. Particularly suitable emollients used in mascara include cetyl alcohol. Particularly suitable thickeners used in mascara include gum arabic.

[0064] In another aspect, the eye makeup is an eyeliner. The eyeliner may contain the preservative composition disclosed herein, water, pigments, film-forming agents, emollients, thickeners, binders, solvents, and sunscreens. Particularly suitable emollients used in eyeliners include glycerin. Particularly suitable thickeners used in eyeliners include xanthan gum. Particularly suitable solvents used in eyeliners include ethanol, and particularly suitable sunscreens used in eyeliners include titanium dioxide.

[0065] In another embodiment, the lip cosmetic is a lipstick. The lipstick may contain the preservative compositions, emollients, humectants, occlusives, flavorings, fragrances, sunscreen ingredients, antioxidants, healing agents, and pigments disclosed herein. Particularly suitable emollients and humectants used in lipsticks include beeswax, shea butter, cocoa butter, lanolin, coconut oil, and jojoba oil. Particularly suitable occlusives used in lipsticks include petrolatum and castor seed oil. Particularly suitable antioxidants used in lipsticks include vitamin E and aloe vera extract, while particularly suitable healing agents used in lipsticks include allantoin and calendula extract.

[0066] In one particular embodiment, the personal care product is a deodorant. Deodorant products may include roll-on deodorant products, spray deodorant products, stick deodorant products, or wipe-on deodorant products. Although the ingredients in a deodorant product may vary depending on whether the product is a stick, roll-on, gel, cream, or spray product, most of the ingredients remain consistent across all deodorant product formulations.

[0067] Deodorant products, for example, may contain the preservative compositions, antiperspirant active ingredients, deodorant ingredients, emollients, humectants, thickeners, stabilizers, skin conditioning agents, antibacterial agents, solvents, and propellants disclosed herein. Particularly suitable antiperspirant active ingredients for use in deodorant products include aluminum compounds such as aluminum chloride hydrate and aluminum tetrachlorohydroxyl glycine. Particularly suitable deodorant ingredients for use in deodorant products include fragrances, sodium bicarbonate, and zinc compounds such as zinc ricinoleate. Particularly suitable emollients and humectants for use in deodorant products include glycerin, shea butter, cocoa butter, and jojoba oil. Particularly suitable skin conditioning agents for use in deodorant products include aloe vera and vitamin E (e.g., tocopheryl acetate). Particularly suitable antibacterial agents for use in deodorant products include triclosan, and particularly suitable solvents for use in deodorant products include propylene glycol. Particularly suitable emollients and humectants for use in deodorant products include glycerin, shea butter, cocoa butter, and jojoba oil.

[0068] Hair care products may include, but are not limited to, conditioners, shampoos, styling products, hair treatment products, and hair dyes.

[0069] In one aspect, the hair care product is a hair conditioner. The hair conditioner may contain the preservative composition disclosed herein, water, emollients, surfactants, silicones, natural oils, humectants, panthenol, fragrances, and pH adjusters. Particularly suitable emollients used in hair conditioners include cetyl alcohol and stearyl alcohol. Particularly suitable surfactants used in hair conditioners include cationic surfactants such as hexadecyltrimethylammonium chloride and betainetrimethylammonium chloride. Particularly suitable silicones used in hair conditioners include polydimethylsiloxane and cyclodimethylsiloxane. Particularly suitable natural oils used in hair conditioners include argan oil and coconut oil, and particularly suitable humectants used in hair conditioners include glycerin. Particularly suitable pH adjusters used in hair conditioners include citric acid.

[0070] On the other hand, the hair care product is a shampoo. The shampoo may contain the preservative composition disclosed herein, water, surfactants, cocamidopropyl betaine, cocamidopropyl DEA or cocamidopropyl MEA, conditioning agents, fragrances, citric acid, sodium chloride, glyceryl distearate, and natural extracts or oils. Particularly suitable surfactants for use in shampoos include sodium lauryl sulfate and sodium lauryl polyoxyethylene ether sulfate. Particularly suitable conditioning agents for use in shampoos include polyquaternium-10 and guar hydroxypropyltrimethylammonium chloride. Particularly suitable natural extracts or oils for use in shampoos include aloe vera and tea tree oil.

[0071] Oral care products may include, but are not limited to, toothpaste and mouthwash.

[0072] In one aspect, the oral care product is toothpaste. Toothpaste may contain the preservative compositions, abrasives, fluorides, detergents, humectants, binders, flavoring agents, sweeteners, desensitizers, and whitening agents disclosed herein. Particularly suitable abrasives used in toothpaste include calcium carbonate and silica. Particularly suitable fluoride compounds used in toothpaste include sodium fluoride and sodium monofluorophosphate. Particularly suitable detergents used in toothpaste include sodium lauryl sulfate. Particularly suitable humectants used in toothpaste include glycerin and sorbitol. Particularly suitable binders used in toothpaste include xanthan gum. Particularly suitable flavoring agents used in toothpaste include peppermint and spearmint. Particularly suitable sweeteners used in toothpaste include saccharin and sorbitol. Particularly suitable desensitizers used in toothpaste include potassium nitrate and strontium chloride. Particularly suitable whitening agents used in toothpaste include hydrogen peroxide and sodium bicarbonate.

[0073] In another aspect, the oral care product is a mouthwash. The mouthwash may contain the preservative composition disclosed herein, water, alcohol, antibacterial agent, flavoring agent, sweetener, coloring agent, pH adjuster, preservative, fluoride, and desensitizing agent. Particularly suitable alcohol compounds for use in mouthwash include ethanol and isopropanol. Particularly suitable antimicrobial agents for use in mouthwash include hexadecylpyridinium chloride and chlorhexidine. Particularly suitable flavoring agents for use in mouthwash include menthol and eucalyptus oil. Particularly suitable sweeteners for use in mouthwash include saccharin and xylitol. Particularly suitable pH adjusters for use in mouthwash include sodium hydroxide and citric acid.

[0074] Skincare products include, but are not limited to, body care cosmetics, eye care cosmetics, face and neck care cosmetics, foot care cosmetics, lip care cosmetics, sunscreen, after-sun cosmetics, and self-tanning cosmetics.

[0075] In one aspect, the skincare product is a sunscreen. The sunscreen may contain the preservative composition disclosed herein, active sunscreen ingredients, emollients, emulsifiers, thickeners, antioxidants, fragrances, water, and pH adjusters. Particularly suitable active sunscreen ingredients used in sunscreens include avobenzone, octyl salicylate, octocrylene, peryl salicylate, octyl methoxycinnamate, zinc oxide, and titanium dioxide. Particularly suitable emollients used in sunscreens include glycerin and caprylic / capric triglycerides. Particularly suitable emulsifiers used in sunscreens include cetearyl alcohol and polysorbate 60. Particularly suitable thickeners used in sunscreens include xanthan gum. Particularly suitable antioxidants used in sunscreens include vitamin E and green tea extract. Particularly suitable pH adjusters used in sunscreens include citric acid.

[0076] Bath products include, but are not limited to, facial cleansers, body cleansers, hand cleansers, soap bars, liquid soaps, feminine care products, and pre-moistened wipes.

[0077] In one aspect, the bath product is a facial cleanser. This facial cleanser may contain the preservative composition disclosed herein, water, surfactants, emollients, emulsifiers, moisturizers, preservatives, fragrances or essential oils, exfoliants, and anti-acne ingredients. Surfactants particularly suitable for facial cleansers include sodium lauryl sulfate and sodium cocoyl ethanesulfonate. Emollients particularly suitable for facial cleansers include glycerin and caprylic / capric triglycerides. Emulsifiers particularly suitable for facial cleansers include polysorbate 20. Moisturizers particularly suitable for facial cleansers include propylene glycol. Exfoliants particularly suitable for facial cleansers include salicylic acid and glycolic acid. Anti-acne ingredients particularly suitable for facial cleansers include benzoyl peroxide and salicylic acid.

[0078] On the other hand, the bath product is a body cleanser. This body cleanser may contain the preservative composition disclosed herein, water, surfactants, emollients, moisturizers, and fragrances or essential oils. Surfactants particularly suitable for body cleansers include sodium lauryl polyoxyethylene ether sulfate or cocamidopropyl betaine. Emollients particularly suitable for body cleansers include shea butter and jojoba oil. Moisturizers particularly suitable for body cleansers include glycerin.

[0079] In another aspect, the bath product is a hand cleanser. The hand cleanser may contain the preservative composition disclosed herein, alcohol compounds, water, emollients and humectants, thickeners, and fragrances. Particularly suitable alcohol compounds for use in hand cleansers include ethanol and isopropanol. Particularly suitable emollients and humectants for use in hand cleansers include aloe vera and glycerin. Particularly suitable thickeners for use in hand cleansers include carbomer.

[0080] On the other hand, the bath product is a soap bar. The soap bar may contain the preservative composition disclosed herein, sodium shea butter or sodium palmitate, sodium cocoate, fragrance or essential oil, and colorant.

[0081] In one aspect, the bath product is a liquid soap. The liquid soap may contain the preservative composition disclosed herein, water, surfactants, emollients, humectants, and fragrances or essential oils. Particularly suitable surfactants for use in liquid soap include sodium lauryl sulfate and cocamidopropyl betaine. Particularly suitable emollients for use in liquid soap include glycerin and shea butter. Particularly suitable humectants for use in liquid soap include propylene glycol.

[0082] The preservative composition may also be incorporated into household care products, such as fabric care products, dishwashing liquids, hard surface cleaners, and bathroom cleaning and care products. Household care product formulations may include general-purpose cleaners and other similar household formulations.

[0083] The fabric care products include, but are not limited to, fabric finishing agents, laundry detergents, laundry capsules or pouches, ironing aids, stain removers, carpet cleaners, washing machine cleaning solutions, and fabric whitening solutions.

[0084] In one respect, the fabric care product is a laundry detergent. Although the ingredients in laundry detergent may vary depending on whether the product is a liquid, a capsule, or a capsule, most of the ingredients are consistent across all laundry detergent formulations.

[0085] Therefore, in another embodiment, the laundry detergent may comprise the preservative composition disclosed herein, surfactants, enzymes, dyes, tinting dyes, chelating agents, stabilizers, free radical scavengers, fragrances, optical brighteners, antifoaming agents, dirt suspending polymers, dirt releasing polymers, dye transfer inhibitors, fabric softening additives, rheology modifiers, washing or cleaning aids, and other polymers.

[0086] Particularly suitable surfactants for use in laundry detergents include nonionic surfactants such as alkoxylated fatty alcohol nonionic surfactants, amphoteric surfactants such as β-n-alkylaminopropionic acid, n-alkyl-β-iminodipropionic acid, imidazoline carboxylates, amine oxides, sulfobetaine, betaine, phosphocholine, propionate, dipropionate, sodium N-cocamidoethyl-N-hydroxyethylaminoacetate, disodium N-cocamidoethyl-N-hydroxyethylaminodiacetate, 3-[(3-cholamidopropyl)dimethylammonium]-1-propanesulfonate (CHAPS), dipalmitoylphosphatidylcholine (DPPtdCho), sodium N-lauromamidoethyl-N-hydroxyethylaminoacetate, or any combination thereof.

[0087] Particularly suitable enzymes for use in laundry detergents include proteases, amylases, cellulases, lipases, mannanases, pectinases, subtilisin, and mixtures thereof.

[0088] Particularly suitable tinting dyes for use in laundry detergents include Basic Violet 3 (Cl 42555) and Basic Violet 4 (Cl 426000), both of which are available from Standard Dyes.

[0089] Particularly suitable chelating agents used in laundry detergents include DTPA, HEDP, DTPMP, GLDA, MGDA, citrate, EDTA, IDS, dipyridinecarboxylic acid, and mixtures thereof.

[0090] Particularly suitable free radical scavengers used in laundry detergents include trimethoxybenzoic acid.

[0091] Particularly suitable optical brighteners for use in laundry detergents include Tinopal CBS-X.

[0092] Particularly suitable defoamers for use in laundry detergents include non-fatty acid defoamers such as silica / silicone, silicone oil, alcohols (such as branched alcohols), polydimethylsiloxane and mixtures thereof.

[0093] Particularly suitable dirt-suspending polymers for use in laundry detergents include PEI ethoxylates, HDMA diquaternary ammonium ethoxylates, sulfonated derivatives, and hydrophobically modified copolymers.

[0094] Particularly suitable dirt-releasing polymers for use in laundry detergents include PET alkoxylated short block copolymers.

[0095] Particularly suitable dye transfer inhibitors and fixing agents included in laundry detergents include polyvinylpyrrolidone, poly-4-vinylpyridine-N-oxide, copolymers of N-vinyl-2-pyrrolidone and N-vinylimidazole, and mixtures thereof.

[0096] Particularly suitable fabric softening additives used in laundry detergents include alkyl quaternary ammonium compounds, ester quaternary ammonium compounds, bentonite, silicone, cationic silicone, and mixtures thereof.

[0097] Particularly suitable rheology modifiers for use in laundry detergents include methylcellulose, hydroxypropyl methylcellulose, xanthan gum, gellan gum, guar gum and hydroxypropyl guar gum, succinosaccharides, and trihydroxystearate.

[0098] Particularly suitable detergent or cleaning aids for use in laundry detergents include ethanolamine citrate, ethanolamine laurylate, ethanolamine palmitate, ethanolamine oleate, ethanolamine stearate, C16 to C18 fatty acids, C18 unsaturated fatty acids, pentasodium pentaacetate, sodium laurylate, sodium dodecyl sulfate, sodium myristate, sodium oleate, sodium palmitate, sodium polyacrylate, sodium stearate, and mixtures thereof.

[0099] Particularly suitable stabilizers and blending agents used in laundry detergents include calcium formate, diethylene glycol, dipropylene glycol, alcohols, ethanolamine, glycerin, hydrogenated castor oil, monoethanolamine citrate, polyethylene glycol, sodium bisulfite, sodium carbonate, sodium citrate, sodium cumene sulfonate, sodium formate, sodium silicate, trimethylsiloxysilicate, or mixtures thereof.

[0100] Hard surface cleaners include, but are not limited to, general cleaners, bathroom cleaners, kitchen cleaners, cleaning pastes, floor cleaners, and furniture care products.

[0101] In one respect, the hard surface cleaner is a general-purpose cleaner. The general-purpose cleaner may contain the preservative composition disclosed herein, water, surfactant, solvent, emulsifier, pH adjuster, and fragrance. Particularly suitable surfactants for general-purpose cleaners include sodium lauryl sulfate and decyl glucoside. Particularly suitable solvents for general-purpose cleaners include isopropanol and ethanol. Particularly suitable emulsifiers for general-purpose cleaners include polysorbate 20. Particularly suitable pH adjusters for general-purpose cleaners include citric acid and sodium hydroxide.

[0102] On the other hand, the hard surface cleaner is a bathroom cleaner. Bathroom cleaners may contain the preservative compositions of this disclosure, acidic compounds, surfactants, fragrances, and thickeners. Particularly suitable acidic compounds used in bathroom cleaners include hydrochloric acid and citric acid.

[0103] In another aspect, the hard surface cleaner is a kitchen cleaner. Kitchen cleaners may contain the preservative compositions, surfactants, solvents, degreasers, fragrances, and antibacterial agents disclosed herein. Particularly suitable degreasers used in kitchen cleaners include sodium carbonate and sodium bicarbonate.

[0104] In one aspect, the hard surface cleaner is a cleaning cream. This cleaning cream may contain the preservative composition, abrasive, surfactant, emollient, and fragrance disclosed herein. Particularly suitable abrasives used in the cleaning cream include calcium carbonate and silica. Particularly suitable emollients used in the cleaning cream include glycerin.

[0105] On the other hand, the hard surface cleaner is a floor cleaner. This floor cleaner may contain the preservative composition disclosed herein, water, surfactants, solvents, fragrances, and pH adjusters.

[0106] Dishwashing liquids include, but are not limited to, hand-washing dishwashing liquids, machine-washing dishwashing liquids, dishwashing capsules, rinsing aids, and dishwashing cleaning solutions.

[0107] In one aspect, the dishwashing liquid is a hand-washing dishwashing liquid. The hand-washing dishwashing liquid may contain the preservative composition disclosed herein, water, surfactants, emollients, solvents, and fragrances. Particularly suitable surfactants for hand-washing dishwashing liquids include sodium lauryl sulfate and cocamidopropyl betaine. Particularly suitable emollients for hand-washing dishwashing liquids include glycerin. Particularly suitable solvents for hand-washing dishwashing liquids include isopropanol.

[0108] In another aspect, the dishwashing liquid is a machine-washable dishwashing liquid. The machine-washable dishwashing liquid may contain the preservative composition, surfactant, enzyme, detergent builder, bleach, anti-redeposition agent, and rinsing aid of this disclosure. Particularly suitable enzymes for use in machine-washable dishwashing liquids include proteases and amylases. Particularly suitable detergent builders for use in machine-washable dishwashing liquids include sodium carbonate and sodium citrate. Particularly suitable bleaching agents for use in machine-washable dishwashing liquids include sodium percarbonate. Particularly suitable anti-redeposition agents for use in machine-washable dishwashing liquids include polyacrylates.

[0109] On the other hand, the dishwashing liquid is a dishwashing capsule or capsule pack. This dishwashing capsule or capsule pack may contain the preservative composition, surfactant, enzyme, detergent builder, bleach, rinsing aid, and solvent disclosed herein. Solvents particularly suitable for dishwashing capsules or capsule packs include PEG-75 and PEG-150.

[0110] In one aspect, the dishwashing liquid is a rinsing aid. This rinsing aid may comprise the preservative composition disclosed herein, water, surfactants, acidifiers, chelating agents, and defoamers. Particularly suitable acidifiers used in rinsing aids include citric acid. Particularly suitable chelating agents used in rinsing aids include tetrasodium EDTA.

[0111] Bathroom care products include, but are not limited to, toilet cleaners and bathroom air fresheners.

[0112] In one aspect, the toilet care product is a toilet cleaner. The toilet cleaner may contain the preservative composition disclosed herein, hydrochloric acid or sulfuric acid, surfactants, thickeners, fragrances, colorants, corrosion inhibitors, bleaching agents, solvents, and antibacterial agents. Particularly suitable surfactants used in toilet cleaners include sodium lauryl sulfate and alkyl dimethylamine oxide. Particularly suitable thickeners used in toilet cleaners include xanthan gum and sodium chloride. Particularly suitable thickeners used in toilet cleaners include sodium hydroxide and sodium polyacrylate. Particularly suitable solvents used in toilet cleaners include isopropanol.

[0113] In these different types of products, the preservative composition and the base composition can be formulated differently depending on the function of the end-use product. For example, the preservative compositions disclosed herein can be used in emulsions (oil-in-water and water-in-oil), aqueous solutions, PIT (phase transition temperature) emulsions, oil solutions, foaming cosmetic formulations (foams), and so-called multiple emulsions, such as triple emulsions (e.g., water / oil / water emulsions).

[0114] The base compositions disclosed herein can also be formulated into liquid, semi-solid, or solid forms, such as creams, gels, liquids, or emulsions. These liquid, semi-solid, and solid base compositions can be used in hair care products, such as shampoos, conditioners, hair dyes, hair growth agents, hair gels, hair styling products, hair combing aids, and other hair care products; shaving products, such as shaving creams, aftershaves, and other shaving products; body and hand personal cleansers, such as liquid bath soaps and detergents; fragrance products, such as perfumes, after-bath sprays, and other similar fragrance products; skin care products, such as moisturizing creams, lotions, and other similar skin care products; cosmetics, such as mascaras, foundations, etc.; makeup removers, sunscreens, tanning products, and other similar personal care products. One specific use of this preservative composition is incorporation into wipe solutions for pre-moistening wipes. These pre-moistened wipes can be used for personal hygiene and cleaning, such as baby wipes, wet toilet wipes, makeup remover wipes, and exfoliating wipes.

[0115] When the preservative composition is used in saturated pre-wetted wipes, it protects the pre-wetted wipe formulation and the wipes before use. Once the pre-wetted wipe composition is formulated, it is applied to the substrate.

[0116] For example, the pre-moistened wipes may be disposable wipes impregnated with the aforementioned preparation or wiping solution and stored in a container for dispensing wipes to a user. The container containing the wipes may contain one or more wipes.

[0117] Suitable wipe-off fabric substrates include both woven and nonwoven materials. Essentially any nonwoven web material can be used. Exemplary nonwoven materials may include, but are not limited to, meltblown, co-formed, spunbond, air-laid, air-entangled nonwoven materials, hydroentangled, bonded carded webs, and their laminates. The fibers used to prepare the wipe-off fabric substrate can be cellulose fibers, thermoplastic fibers, and mixtures thereof. The fibers can also be continuous fibers, discontinuous fibers, short fibers, and mixtures thereof. The basis weight of the nonwoven web can vary from about 12 g / m² to 200 g / m² or higher.

[0118] Once incorporated into the substrate, the resulting wipes can have a liquid to substrate weight ratio of about 5:1 to about 1:1, for example about 2:1 to about 4:1.

[0119] As demonstrated, the composition can be incorporated into many different end-use formulations or products, such as personal care or home care products.

[0120] Typically, the preservative composition disclosed herein can be added to the end-use formulation to be preserved in an amount of 0.001% to about 10% of the formulation weight. More specifically, the preservative composition is added in an amount of about 0.1% to 5.0% of the formulation weight.

[0121] In one aspect, the pyrithione compounds are present in the base composition of personal care or home care products in amounts less than about 1000 ppm, for example, less than about 500 ppm, for example, less than about 250 ppm, for example, less than about 100 ppm, or even, for example, less than 50 ppm. Pyrithiones may be present in the base composition of personal care or home care products in amounts greater than about 1 ppm, for example, greater than about 5 ppm, for example, greater than about 10 ppm, for example, greater than about 10 ppm, for example, greater than about 15 ppm, for example, greater than 20 ppm, or even, for example, greater than about 25 ppm.

[0122] The following examples are for illustrative purposes only and do not limit the scope of the invention. Unless otherwise stated, all parts and percentages are given by weight.

[0123] To demonstrate the synergistic effect, the following embodiments were carried out.

[0124] 1 example

[0125] The synergistic activity of pyrithione, organic acids or their salts, and aromatic alcohols as part of a three-component composition has been demonstrated.

[0126] The sodium 1-oxo-2-mercaptopyridine used was OMADINE® purchased from Arxada AG.

[0127] A wide range of concentrations were tested against the following microorganisms: Pseudomonas aeruginosa ( Pseudomonas aeruginosa ATCC 9027 / DSM 1128 and Candida albicans ( Candida albicans ATCC 10231 / DSM 1386.

[0128] The lowest concentration of each mixture or single compound that inhibits observable growth at a level of 100% was determined as the minimum inhibitory concentration (MIC). MIC values ​​were determined for each microorganism.

[0129] A series of dilutions were prepared for each mixture or single compound. Microorganisms were inoculated into culture media: nutrient broth (bacteria) or malt extract broth (yeast). The final concentration of microorganisms in the culture medium was approximately 10⁵ CFU / ml. The inoculated culture medium was introduced into each series of dilutions at a 1:1 ratio and incubated at 30 ± 1°C for 24–48 hours.

[0130] The MIC of each mixture was compared with the MIC of each single compound.

[0131] The synergistic effect was determined using a synergistic index (“SI”) value, calculated using a method based on the Kull equation (FC Kull et al., “Mixtures of Quaternary Ammonium Compounds and Long-chain Fatty Acids as Antifungal Agents”, Appl Microbiol. 1961 Nov; 9(6):538–541).

[0132]

[0133] in

[0134] QA = The concentration (ppm) of compound A that produces the endpoint when used alone;

[0135] Qa = Concentration of compound A at which the endpoint is reached in the mixture (ppm);

[0136] QB = The concentration (ppm) of compound B that produces the endpoint when used alone;

[0137] Qb = Concentration (ppm) of compound B in the mixture at which the endpoint is reached;

[0138] QC = the concentration (ppm) of compound C that produces the endpoint when used alone; and

[0139] Qc = The concentration (ppm) of compound C in the mixture at which the endpoint is reached.

[0140] In this study, the endpoint was measured using the MIC (Micro-Melodyspheric Index). An SI value less than 1 indicates a synergistic effect. An SI value equal to 1 indicates an additive effect. An SI value greater than 1 indicates an antagonistic effect.

[0141] Table 1.

[0142] Synergy Index: Summary of synergistic interactions between aromatic alcohols and organic acids or their salts and sodium 1-oxo-2-mercaptopyridine.

[0143]

[0144] Data is currently being generated, therefore, the synergistic interaction between benzyl alcohol, itaconic acid, and sodium 1-oxo-2-mercaptopyridine is predictable.

[0145] Table 2.

[0146] 1-O-2-mercaptopyridine sodium: phenoxyethanol: sodium benzoate

[0147] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0148]

[0149] Table 3.

[0150] 1-O-2-mercaptopyridine sodium: phenoxyethanol: sodium benzoate

[0151] Candida albicans ( Candida albicans )

[0152]

[0153] Table 4.

[0154] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Potassium sorbate

[0155] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0156]

[0157] Table 5.

[0158] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Potassium sorbate

[0159] Candida albicans ( Candida albicans )

[0160]

[0161] Table 6.

[0162] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Lactic acid

[0163] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0164]

[0165] Table 7.

[0166] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Lactic acid

[0167] Candida albicans ( Candida albicans )

[0168]

[0169] Table 8.

[0170] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Alevopropionic acid

[0171] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0172]

[0173] Table 9.

[0174] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Alevopropionic acid

[0175] Candida albicans ( Candida albicans )

[0176]

[0177] Table 10.

[0178] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Itaconic acid

[0179] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0180]

[0181] Table 11.

[0182] Ternary FIC: Sodium 1-O-2-mercaptopyridine: Phenoxyethanol: Itaconic acid

[0183] Candida albicans ( Candida albicans )

[0184]

[0185] Table 12.

[0186] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Sodium benzoate

[0187] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0188]

[0189] Table 13.

[0190] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Sodium benzoate

[0191] Candida albicans ( Candida albicans )

[0192]

[0193] Table 14.

[0194] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Potassium sorbate

[0195] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0196]

[0197] Table 15.

[0198] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Potassium sorbate

[0199] Candida albicans ( Candida albicans )

[0200]

[0201] Table 16.

[0202] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Citric acid

[0203] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0204]

[0205] Table 17.

[0206] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Citric acid

[0207] Candida albicans ( Candida albicans )

[0208]

[0209] Table 18.

[0210] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Alevopropionic acid

[0211] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0212]

[0213] Table 19.

[0214] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Lactic acid

[0215] Pseudomonas aeruginosa ( Pseudomonas aeruginosa )

[0216]

[0217] Table 20.

[0218] Ternary FIC: Sodium 1-oxo-2-mercaptopyridine: Benzyl alcohol: Lactic acid

[0219] Candida albicans ( Candida albicans )

[0220]

Claims

1. A preservative composition comprising: (a) a thiopyridine compound, (b) an organic acid or a salt thereof; and (c) a fragrant alcohol; wherein the preservative composition exhibits a synergistic effect; and wherein the weight ratio of the thiopyridine compound to the organic acid or a salt thereof and the fragrant alcohol is from about 1 : 1 : 1 to about 1 : 15,630 : 12,500.

2. The preservative composition according to claim 1, wherein the weight ratio of the thiopyridine compound to the organic acid or a salt thereof and the fragrant alcohol is from about 1 : 1 : 1 to about 1 : 15,630 : 12,500, for example from about 1 : 1 : 1 to about 1 : 10,000 : 10,000, for example from about 1 : 1 : 1 to about 1 : 5,000 : 5,000.

3. The preservative composition according to claim 1 or 2, wherein the thiopyridine compound comprises a water-soluble thiopyridine.

4. The preservative composition according to any one of the preceding claims, wherein the thiopyridine compound comprises sodium 1 -oxo-2-mercaptopyridine.

5. The preservative composition according to any one of the preceding claims, wherein the fragrant alcohol comprises phenoxyethanol.

6. The preservative composition according to any one of claims 1 to 4, wherein the fragrant alcohol comprises benzyl alcohol.

7. The preservative composition according to any one of the preceding claims, wherein the organic acid or a salt thereof comprises itaconic acid.

8. The preservative composition according to any one of claims 1 to 6, wherein the organic acid or a salt thereof comprises lactic acid, levulinic acid, citric acid or a mixture thereof.

9. The preservative composition according to any one of claims 1 or 2, wherein the thiopyridine compound comprises sodium 1 -oxo-2-mercaptopyridine, the fragrant alcohol comprises phenoxyethanol and the organic acid or a salt thereof comprises citric acid, lactic acid, benzoic acid or sorbic acid.

10. The preservative composition according to any one of claims 1 or 2, wherein the thiopyridine compound comprises sodium 1 -oxo-2-mercaptopyridine, the fragrant alcohol comprises benzyl alcohol and the organic acid or a salt thereof comprises citric acid, lactic acid, benzoic acid or sorbic acid.

11. A personal care or home care composition comprising: a base composition; and a preservative composition as defined in any one of claims 1 to 10.

12. The personal care or home care composition according to claim 11, wherein the content of the thiopyridine compound in the base composition is less than about 1000 ppm, for example a content of less than about 500 ppm, for example a content of less than about 250 ppm, for example a content of less than about 100 ppm, for example a content of less than about 50 ppm.

13. The personal care or home care composition according to claim 11 or 12, wherein the weight ratio of the thiopyridine compound to the organic acid or a salt thereof and the fragrant alcohol is from about 1 : 1 : 1 to about 1 : 15,630 : 12,500, for example from about 1 : 1 : 1 to about 1 : 10,000 : 10,000, for example from about 1 : 1 : 1 to about 1 : 5,000 : 5.

000.

14. The personal care or home care composition according to any one of claims 11 to 13, wherein the base composition comprises a liquid, semi-solid, or solid.

15. The personal care or home care composition according to any one of claims 11 to 14, wherein the personal care or home care composition comprises a color-added make-up product, a deodorant product, a hair care product, an oral care product, a skin care product, or a bath product.

16. The personal care or home care composition according to any one of claims 11 to 14, wherein the personal care or home care composition comprises a hand dishwashing soap, a machine dishwashing soap, a machine dishwashing rinse aid, a laundry detergent, a laundry fabric conditioner, a laundry fragrance and / or wrinkle treatment, an ironing aid, a cleaning wipe, an all-purpose cleaner, and other similar formulations for use around the home. In one embodiment, the home care product is a cleaning product selected from the group consisting of a hand dishwashing soap, a laundry detergent, a cleaning wipe, and an all-purpose cleaner, such as a floor, countertop, kitchen, carpet, bathroom, and shower cleaner.

17. The personal care or home care composition according to any one of claims 11 to 14, wherein the personal care or home care composition comprises a pre-moistened wipe.

18. The personal care or home care composition according to any one of claims 11 to 17, wherein the base composition comprises at least one of a solvent, a surfactant, a complexing agent, a corrosion inhibitor, an alkalinity enhancer, a pH adjuster, an adjuvant, an acid, a foaming agent, a fragrance, a colorant, a humectant, an emulsifier, a thickening agent, an antioxidant, an ultraviolet light blocker, a wax, a natural extract, or an oil.

19. A method of increasing the efficacy of a preservative in an end-use formulation, the method comprising adding to an end-use formulation a preservative comprising the composition according to any one of claims 1 to 10.

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