A traditional Chinese medicine composition for treating peripheral nerve toxicity of limbs after chemotherapy

Abstract

The present application belongs to the technical field of traditional Chinese medicine composition, and discloses a traditional Chinese medicine composition for treating peripheral nerve toxicity after chemotherapy, which is composed of 10-20 parts of cassia twig, 10-20 parts of mugwort leaf, 5-15 parts of dried ginger, 5-15 parts of chuanxiong rhizome, 5-15 parts of red peony root, 5-15 parts of safflower, 5-15 parts of clematis, 20-40 parts of lonicera japonica, 5-15 parts of astragalus, 5-15 parts of rhabdophis, 5-15 parts of earthworm, 5-15 parts of scorpion and 1-5 parts of asarum, according to the weight component. The traditional Chinese medicine composition has the effects of warming yang and dispelling cold, promoting blood circulation and dredging collaterals, and dispelling wind and relieving pain, and is administered by fumigation and washing, so that the drug power and heat power are synergistic, directly reach the lesion site of the extremity periphery, and have rapid effect, and can effectively improve the nerve toxicity symptoms such as numbness, pain and paresthesia of the extremity caused by chemotherapy, and can be used for preparing a medicine for treating peripheral nerve toxicity caused by chemotherapy.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, specifically a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy. Background Technology

[0002] Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity of antitumor drugs, mainly occurring in cancer patients receiving long-term or high-dose chemotherapeutic drugs such as oxaliplatin, paclitaxel, and platinum-based chemotherapy agents. Its clinical manifestations include symmetrical sensory disturbances in the distal extremities, such as numbness, tingling, burning sensation, and decreased sensation. Some patients also experience motor disorders or autonomic dysfunction. In severe cases, it can even affect limb function and quality of life, leading to dose reduction or discontinuation of chemotherapy, thus impacting the effectiveness of cancer treatment.

[0003] Currently, Western medicine treats CIPN primarily with neurotrophic drugs (such as methylcobalamin and B vitamins), antioxidants (such as alpha-lipoic acid), and symptomatic analgesics (such as duloxetine). However, the clinical efficacy of these drugs is still uncertain, and some analgesics have adverse reactions such as drowsiness, dizziness, and dependence, making it difficult to meet clinical needs.

[0004] Traditional Chinese medicine (TCM) considers chemotherapy drugs to be potent and categorized as "drug toxicity." Drug toxicity damages the body's Yang energy, leading to Yang deficiency, which in turn causes cold stagnation and blood stasis. Poor blood and Qi circulation results in obstructed meridians; prolonged illness can further damage the meridians, causing stagnation and toxins to accumulate, leading to numbness, pain, and sensory abnormalities in the extremities. The core pathogenesis can be summarized as "Yang deficiency with cold stagnation and meridian obstruction." Current TCM treatments primarily involve oral decoctions. However, oral medications require gastrointestinal absorption, resulting in a relatively slow onset of action. Furthermore, long-term use can increase the burden on the gastrointestinal tract for cancer patients with weak spleen and stomach. The extremities, being the extremities of Yang energy, are more susceptible to cold, dampness, and blood stasis due to the difficulty in Yang energy reaching them.

[0005] The fumigation method utilizes heat to open the pores, allowing the medicinal properties to penetrate the skin and directly reach the affected areas in the extremities. It warms and invigorates Yang Qi, dispels cold and unblocks the meridians, promotes blood circulation, removes blood stasis, and dispels wind and unblocks the channels. It avoids the first-pass effect and gastrointestinal irritation associated with oral administration, resulting in a faster onset of action. Therefore, this invention provides a traditional Chinese medicine composition that uses fumigation as a route of administration, can directly act on the affected areas in the limbs after chemotherapy, has a rapid onset of action, and is highly safe, effectively treating CIPN symptoms in the limbs after chemotherapy. Summary of the Invention

[0006] The present invention aims to provide a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, in order to solve the problems in the prior art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, comprising, by weight: 10-20 parts of cinnamon twig, 10-20 parts of mugwort leaf, 5-15 parts of dried ginger, 5-15 parts of chuanxiong rhizome, 5-15 parts of red peony root, 5-15 parts of safflower, 5-15 parts of clematis root, 20-40 parts of honeysuckle vine, 5-15 parts of astragalus root, 5-15 parts of black-striped snake, 5-15 parts of earthworm, 5-15 parts of scorpion, and 1-5 parts of asarum.

[0009] Furthermore, by weight, it consists of 15 parts cinnamon twig, 15 parts mugwort leaf, 10 parts dried ginger, 10 parts chuanxiong rhizome, 10 parts red peony root, 10 parts safflower, 10 parts clematis root, 30 parts honeysuckle vine, 10 parts astragalus root, 10 parts black-striped snake, 10 parts earthworm, 10 parts scorpion, and 3 parts asarum.

[0010] The preparation method of the above-mentioned traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy includes the following steps:

[0011] S1. Raw material preparation and pretreatment

[0012] Weigh the raw materials according to the weight ratio, clean and wash each raw material separately, and then crush each raw material.

[0013] S2, Decoction and Extraction

[0014] The raw materials pretreated in step S1 are put into a decoction container, soaked in water, extracted by heating and decoction, and filtered to obtain the Chinese herbal composition.

[0015] Further, in step S1, for stem and rhizome materials such as cinnamon twigs and astragalus, after cleaning and washing, they are cut into oblique slices or round slices with a thickness of 2-4 mm; for rhizome materials such as dried ginger, chuanxiong, and red peony root, after cleaning and washing, they are cut into slices or chunks with a thickness of 3-5 mm; for leaf and flower materials such as mugwort leaves and safflower, after cleaning and washing, they are cut into segments with a length of 10-20 mm or kept in their original shape; for vine and stem materials such as clematis and honeysuckle vine, after cleaning and washing, they are cut into segments with a length of 15-30 mm; for animal materials such as black-striped snake, earthworm, and scorpion, after cleaning and washing, they are directly crushed or pounded into powder or fragments; for whole herb materials such as asarum, after cleaning and washing, they are cut into segments with a length of 10-15 mm.

[0016] Furthermore, in step S2, the decoction container is a stainless steel pot, a ceramic pot, or an automatic decoction machine, and cold water is added in an amount of 5 to 10 times the total weight of the raw materials, and the mixture is soaked for 30 to 60 minutes.

[0017] Furthermore, in step S2, the extraction is performed twice by heating and decocting. The first extraction is carried out by boiling over high heat and then simmering over low heat for 30 to 40 minutes. The second extraction is carried out by filtering the residue and then adding water and decocting for 20 to 30 minutes. After the two extractions, the decoctions are combined.

[0018] Further, in step S2, the material is filtered through a 200-mesh sieve.

[0019] The above-mentioned traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy is used in the preparation of a drug for treating peripheral neuropathy caused by chemotherapy.

[0020] Furthermore, the medicine includes one of a fumigation agent, a fumigation solution, or a soaking decoction.

[0021] It should be noted that the pharmacological effects of each raw material in this traditional Chinese medicine composition are as follows:

[0022] Cinnamon twig, properties and channels: pungent, sweet, warm; enters the heart, lung, and bladder channels. Functions and indications: induces sweating and relieves muscle tension, warms and unblocks the channels, assists yang and promotes qi circulation. Used for common cold due to wind-cold, abdominal pain due to cold, amenorrhea due to blood stasis, joint pain, phlegm retention, edema, and palpitations.

[0023] Artemisia argyi, properties and channels: pungent, bitter, warm; enters the liver, spleen, and kidney channels. Functions and indications: warms the channels and stops bleeding, dispels cold and relieves pain; externally used to dispel dampness and relieve itching. Used for hematemesis, epistaxis, metrorrhagia, menorrhagia, threatened abortion, lower abdominal pain due to cold, irregular menstruation due to cold, and infertility due to cold uterus; externally used to treat pruritus.

[0024] Dried ginger, properties and channels: pungent, hot; enters the spleen, stomach, kidney, heart, and lung channels. Functions and indications: warms the middle jiao and dispels cold, restores yang and unblocks the channels, warms the lungs and resolves phlegm. Used for cold pain in the epigastrium and abdomen, vomiting and diarrhea, collapse of yang and syncope, cough and wheezing due to cold phlegm, and pain due to cold and dampness.

[0025] Chuanxiong (Ligusticum striatum), properties and channels: pungent, warm; enters the liver, gallbladder, and pericardium channels. Functions and indications: invigorates blood and promotes qi circulation, dispels wind and relieves pain. Used for chest pain, stabbing pain in the chest and hypochondrium, swelling and pain from falls, irregular menstruation, amenorrhea and dysmenorrhea, abdominal masses and pain, headache, and rheumatic pain.

[0026] Red peony root, properties and channels: bitter, slightly cold; enters the liver channel. Functions and indications: clears heat and cools the blood, disperses blood stasis and relieves pain. Used for heat entering the blood level, febrile rashes, hematemesis and epistaxis, red and swollen eyes, liver stagnation and hypochondriac pain, amenorrhea and dysmenorrhea, abdominal masses and pain, traumatic injuries, carbuncles and sores.

[0027] Safflower, properties and channels: pungent, warm; enters the heart and liver channels. Functions and indications: invigorates blood circulation and regulates menstruation, disperses blood stasis and relieves pain. Used for amenorrhea, dysmenorrhea, lochia retention, abdominal masses, chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and ribs, traumatic injuries, sores and swelling.

[0028] Clematis chinensis, properties and channels: pungent, salty, warm; enters the bladder channel. Functions and indications: dispels wind and dampness, unblocks the meridians. Used for rheumatic pain, numbness of limbs, muscle contracture, and difficulty in flexion and extension.

[0029] Honeysuckle vine, properties and channels: sweet, cold; enters the lung and stomach channels. Functions and indications: clears heat and detoxifies, dispels wind and unblocks the channels. Used for febrile diseases, dysentery due to heat toxins, carbuncles and sores, rheumatic arthralgia, and red, swollen, hot and painful joints.

[0030] Astragalus membranaceus (Huang Qi) – Properties and Channels Entered: Sweet, warm; enters the spleen and lung channels. Functions and Indications: Tonifies qi and raises yang, consolidates the exterior and stops sweating, promotes diuresis and reduces swelling, generates fluids and nourishes blood, promotes circulation and relieves pain, promotes pus drainage and detoxification, and promotes tissue regeneration and wound healing. Used for qi deficiency and fatigue, poor appetite and loose stools, sinking of middle qi, chronic diarrhea and rectal prolapse, hematochezia and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, internal heat and thirst, anemia and chlorosis, hemiplegia, numbness and pain, carbuncles and boils that are difficult to ulcerate, and chronic ulcers that do not heal.

[0031] Black-striped snake, properties and meridian tropism: sweet, neutral; enters the liver meridian. Functions and indications: dispels wind, unblocks meridians, and stops spasms. Used for stubborn rheumatism, numbness and contracture, stroke with facial paralysis, hemiplegia, convulsions, tetanus, leprosy, and scabies.

[0032] Earthworm, properties and channels: salty, cold; enters the liver, spleen, and bladder channels. Functions and indications: clears heat and calms convulsions, unblocks channels, relieves asthma, and promotes urination. Used for high fever with delirium, convulsions, joint pain, numbness of limbs, hemiplegia, cough with wheezing due to lung heat, and edema with oliguria.

[0033] Whole scorpion, properties and channels: pungent, neutral; toxic; enters the liver channel. Functions and indications: calms wind and relieves spasms, unblocks channels and relieves pain, attacks toxins and dissipates nodules. Used for internal wind in the liver, spasms and convulsions, infantile convulsions, stroke with facial paralysis, hemiplegia, tetanus, stubborn rheumatism, migraine, sores, and scrofula.

[0034] Asarum, properties and channels: pungent, warm; enters the heart, lung, and kidney channels. Functions and indications: relieves exterior syndromes and dispels cold, dispels wind and relieves pain, clears the nasal passages, warms the lungs and resolves phlegm. Used for common cold due to wind-cold, headache, toothache, nasal congestion and runny nose, rhinitis, sinusitis, rheumatic pain, and cough with phlegm.

[0035] The beneficial effects of the technical solution are:

[0036] 1. This invention provides a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, possessing the effects of warming yang and dispelling cold, promoting blood circulation and unblocking collaterals, and dispelling wind and relieving pain. In this formula, cinnamon twig, mugwort leaf, and dried ginger warm and invigorate yang qi, dispel cold and unblock collaterals, serving as the principal herbs, targeting the core pathogenesis of "yang deficiency and cold stagnation"; chuanxiong rhizome, red peony root, and safflower invigorate blood circulation, remove blood stasis, promote qi circulation and relieve pain, serving as the assistant herbs to relieve "collateral obstruction"; clematis root, black-striped snake, honeysuckle vine, astragalus root, earthworm, and scorpion dispel wind, unblock collaterals, and penetrate the muscles and bones, serving as adjuvant herbs to assist the principal and assistant herbs in unblocking collaterals; among them, astragalus root tonifies qi and strengthens the body, as qi is the commander of blood, assisting blood circulation; honeysuckle vine unblocks collaterals and detoxifies, and can restrain the drying nature of warming herbs; asarum root is pungent and aromatic, penetrating the skin and guiding the medicine through the meridians, serving as the guiding herb. The formula combines warming and invigorating properties, uses cordyceps, balances cold and heat, invigorates qi and promotes blood circulation, and works synergistically to achieve the effects of warming yang and dispelling cold, promoting blood circulation and unblocking collaterals, and relieving wind and pain.

[0037] 2. This invention provides a traditional Chinese medicine composition for treating peripheral neuropathy of the extremities after chemotherapy. Administered externally via fumigation and washing, it offers unique therapeutic advantages. The fumigation method utilizes the synergistic effect of heat and medicinal properties. Through the mechanism of "heat opening the pores and medicinal properties penetrating the skin to reach the affected area," the effective components of the medicine directly act on the lesions in the extremities, achieving transdermal absorption. This avoids the first-pass effect and gastrointestinal irritation associated with oral administration, resulting in a faster onset of action. Simultaneously, the heat itself warms and unblocks the meridians, promoting local blood circulation, which complements the medicinal effects, enhancing the therapeutic effect of warming and unblocking the meridians, and significantly improving patient compliance.

[0038] 3. This invention provides a method for preparing a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy. The desired composition is obtained through pretreatment (cleaning and washing) and decoction processes (precisely controlling soaking time, number of decoctions, and duration to ensure efficient dissolution of active ingredients). This process is simple to operate, requires no complex equipment, is highly repeatable, and is easy to promote and apply in medical institutions or homes, ensuring the stability of efficacy and the feasibility of clinical application. Detailed Implementation

[0039] The present invention will be further described in detail below with reference to the embodiments:

[0040] Example 1: A traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, comprising, by weight, 10-20 parts of cinnamon twig, 10-20 parts of mugwort leaf, 5-15 parts of dried ginger, 5-15 parts of chuanxiong rhizome, 5-15 parts of red peony root, 5-15 parts of safflower, 5-15 parts of clematis root, 20-40 parts of honeysuckle vine, 5-15 parts of astragalus root, 5-15 parts of black-striped snake, 5-15 parts of earthworm, 5-15 parts of scorpion, and 1-5 parts of asarum.

[0041] Example 2: A traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, comprising, by weight, 15 parts of cinnamon twig, 15 parts of mugwort leaf, 10 parts of dried ginger, 10 parts of chuanxiong rhizome, 10 parts of red peony root, 10 parts of safflower, 10 parts of clematis root, 30 parts of honeysuckle vine, 10 parts of astragalus root, 10 parts of black-striped snake, 10 parts of earthworm, 10 parts of scorpion, and 3 parts of asarum.

[0042] Example 3: Preparation of the traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, as described in Example 2, includes the following steps:

[0043] S1. Raw material preparation and pretreatment

[0044] Weigh the raw materials according to the weight ratio, clean and wash each raw material separately, and then crush each raw material.

[0045] Among them, for stem and rhizome raw materials such as cinnamon twigs and astragalus, after cleaning and washing, they are cut into oblique or round slices with a thickness of 2-4 mm; for rhizome raw materials such as dried ginger, chuanxiong, and red peony root, after cleaning and washing, they are cut into slices or chunks with a thickness of 3-5 mm; for leaf and flower raw materials such as mugwort leaves and safflower, after cleaning and washing, they are cut into segments with a length of 10-20 mm or kept in their original shape; for vine and stem raw materials such as clematis and honeysuckle vine, after cleaning and washing, they are cut into segments with a length of 15-30 mm; for animal raw materials such as black-striped snake, earthworm, and scorpion, after cleaning and washing, they are directly crushed or pounded into powder or fragments; for whole herb raw materials such as asarum, after cleaning and washing, they are cut into segments with a length of 10-15 mm.

[0046] S2, Decoction and Extraction

[0047] Put the raw materials pretreated in step S1 into a stainless steel decoction pot (iron pots and aluminum pots are prohibited to prevent discoloration of the decoction and reduction of efficacy), add 8 times the total weight of the raw materials in cold water, and soak for 45 minutes; extract twice by heating and decoction, the first decoction for 35 minutes and the second decoction for 25 minutes; combine the two decoctions and filter them through a 200-mesh sieve to obtain the desired Chinese herbal composition.

[0048] Example 4: The traditional Chinese medicine composition prepared in Example 3 was used for fumigation treatment of peripheral neuropathy in the limbs after chemotherapy.

[0049] (1) Indications and contraindications

[0050] Indications: Symptoms of peripheral neurotoxicity such as numbness, tingling, burning sensation, decreased sensation, and cold extremities in the distal extremities (hands and feet) after chemotherapy; Grading: CTCAE grade 1-2 neurotoxicity;

[0051] Tumor type: Solid tumor patients receiving neurotoxic chemotherapy drugs such as oxaliplatin, taxanes, and platinum-based drugs.

[0052] Absolute contraindications: broken skin, infection, rash on the limbs, allergic constitution (allergic to any of the components), severe heart or kidney failure, high fever (body temperature > 38.5℃);

[0053] Relative contraindications: Diabetic patients with severe peripheral vascular disease, severe sensory impairment (water temperature must be strictly controlled), pregnant and lactating women.

[0054] (2) Specific operation of fumigation

[0055] Step 1: Fumigation. Pour the hot medicinal liquid prepared in Example 3 into the fumigation basin, place the affected area on the support above the basin, cover with a towel to prevent heat dissipation, and fumigate at 70-80℃ (steam) for 5-10 minutes to open the pores and preheat the local area using steam.

[0056] Step 2: Soaking. After the medicinal solution cools down to 40-45℃, completely immerse your hands and feet in the medicinal solution for 20-30 minutes at 40-45℃ to allow the medicine to be absorbed through the skin and have a sustained effect.

[0057] Step 3: Keep warm. When the medicine cools down, you can add more hot medicine to maintain the temperature at 40-45℃ to ensure the effective action time.

[0058] Step 4: Dry off, rinse with warm water after fumigation, dry with a soft towel, and keep warm and away from drafts to prevent catching a cold.

[0059] (3) Frequency and course of treatment

[0060] Frequency: 1-2 times daily.

[0061] Treatment course: One course of treatment lasts for 14 consecutive days, and can be repeated 2 to 3 times.

[0062] Chemotherapy cycle coordination: Start 3 days before chemotherapy and continue until 14 days after chemotherapy, or throughout the entire chemotherapy cycle.

[0063] (4) Precautions

[0064] To prevent burns: test the temperature with the back of your hand first. Elderly people and diabetic patients need assistance from family members. Avoid adding excessively hot medicinal solutions during the fumigation and washing process.

[0065] Time control: Each session should not exceed 30 minutes. Excessive time may cause skin maceration and dehydration.

[0066] Skin reaction: If redness, swelling, itching, or rash occurs, stop immediately and treat with anti-allergy medication if necessary.

[0067] Fasting / Full meal: It is not advisable to do this on an empty stomach or within 1 hour after a full meal.

[0068] Keep warm: After fumigation and washing, pay attention to keeping warm and avoid catching a cold from the wind.

[0069] Blood pressure monitoring: Hypertensive patients should avoid soaking in excessively hot or prolonged water.

[0070] The above descriptions are merely embodiments of the present invention, and common knowledge regarding specific technical solutions or characteristics is not elaborated upon here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the technical solutions of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A traditional Chinese medicine composition for treating peripheral neuropathy of the extremities after chemotherapy, characterized in that, By weight, it consists of 10-20 parts of cinnamon twig, 10-20 parts of mugwort leaf, 5-15 parts of dried ginger, 5-15 parts of chuanxiong rhizome, 5-15 parts of red peony root, 5-15 parts of safflower, 5-15 parts of clematis root, 20-40 parts of honeysuckle vine, 5-15 parts of astragalus root, 5-15 parts of black-striped snake, 5-15 parts of earthworm, 5-15 parts of scorpion, and 1-5 parts of asarum.

2. The traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy according to claim 1, characterized in that, By weight, it consists of 15 parts cinnamon twig, 15 parts mugwort leaf, 10 parts dried ginger, 10 parts chuanxiong rhizome, 10 parts red peony root, 10 parts safflower, 10 parts clematis root, 30 parts honeysuckle vine, 10 parts astragalus root, 10 parts black-striped snake, 10 parts earthworm, 10 parts scorpion, and 3 parts asarum.

3. The method for preparing a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy according to claim 1, characterized in that, Includes the following steps: S1. Raw material preparation and pretreatment Weigh the raw materials according to the weight ratio, clean and wash each raw material separately, and then crush each raw material. S2, Decoction and Extraction The raw materials pretreated in step S1 are put into a decoction container, soaked in water, extracted by heating and decoction, and filtered to obtain the Chinese herbal composition.

4. A method for preparing a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy according to claim 3, characterized in that, In step S1, for stem and rhizome materials such as cinnamon twigs and astragalus, after cleaning and washing, they are cut into oblique or round slices with a thickness of 2-4 mm; for rhizome materials such as dried ginger, chuanxiong, and red peony root, after cleaning and washing, they are cut into slices or chunks with a thickness of 3-5 mm; for leaf and flower materials such as mugwort leaves and safflower, after cleaning and washing, they are cut into segments with a length of 10-20 mm or kept in their original shape; for vine and stem materials such as clematis and honeysuckle vine, after cleaning and washing, they are cut into segments with a length of 15-30 mm; for animal materials such as black-striped snake, earthworm, and scorpion, after cleaning and washing, they are directly crushed or pounded into powder or fragments; for whole herb materials such as asarum, after cleaning and washing, they are cut into segments with a length of 10-15 mm.

5. A method for preparing a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, as described in claim 3, characterized in that, In step S2, the decoction container is a stainless steel pot, a ceramic pot, or an automatic decoction machine. Add cold water in a volume of 5 to 10 times the total weight of the raw materials and soak for 30 to 60 minutes.

6. A method for preparing a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, as described in claim 3, characterized in that, In step S2, the extraction is performed twice by heating and decocting. The first extraction is carried out by boiling over high heat and then simmering over low heat for 30 to 40 minutes. The second extraction is carried out by filtering the residue and adding water to decoct for 20 to 30 minutes. The decoctions are combined after the two extractions.

7. A method for preparing a traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy, as described in claim 3, characterized in that, In step S2, the material is filtered through a 200-mesh sieve.

8. The use of the traditional Chinese medicine composition for treating peripheral neuropathy of the limbs after chemotherapy as described in claim 1 in the preparation of a medicament for treating peripheral neuropathy caused by chemotherapy.

9. The application of the traditional Chinese medicine composition for treating peripheral neuropathy of the extremities after chemotherapy according to claim 8 in the preparation of a medicament for treating peripheral neuropathy caused by chemotherapy, characterized in that, The medicine includes one of the following: fumigation agent, fumigation solution, or soaking decoction.