Synthesis method and application of beta-fluorosulfonyl sulfone compound

By generating alkyl radicals through photo-oxidation-reduction catalysis, the high difficulty in synthesizing β-fluorosulfonyl sulfone compounds in existing technologies has been solved, achieving efficient synthesis and diversified products, which are applicable to organic synthesis, drug development and polymer materials.

CN122145356APending Publication Date: 2026-06-05ZHEJIANG NORMAL UNIV
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Patent Information

Application Number
CN202610256471.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-04
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing technologies for synthesizing β-fluorosulfonyl sulfone compounds rely on a limited variety of raw materials and are difficult to synthesize, making it hard to meet the demand for structurally diverse intermediates in various applications.

Method used

Potassium trifluoroborate compounds were used as free radical precursors, combined with a photocatalyst, a sulfur dioxide source, and a hydrogen source, to carry out photo-oxidation-reduction catalysis under light irradiation to generate alkyl free radicals. Sulfonyl fluoride groups were then efficiently introduced at the β-position of the sulfone group through a free radical addition reaction.

Benefits of technology

This provides an efficient and simple synthetic route with high yield. The sulfonyl fluoride group has good potential for subsequent transformation and is suitable for organic synthesis, drug development and polymer materials.

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Abstract

The invention discloses a synthesis method and application of a beta-fluorosulfonyl sulfone compound, and belongs to the technical field of chemical synthesis and medicinal chemistry. The method comprises the following steps: in a protective atmosphere, in an organic solvent, mixing a potassium trifluoroborate compound, a photocatalyst, a sulfur dioxide source, a hydrogen source and ethylene sulfonyl fluoride, and carrying out a reaction under an illumination condition to obtain the beta-fluorosulfonyl sulfone compound. According to the invention, preparation of a series of beta-fluorosulfonyl sulfone compounds can be realized, a new synthesis method is provided for synthesis of the beta-fluorosulfonyl sulfone compounds, sulfuryl and sulfonyl fluoride are parts of molecular structures of various drugs, and the compound is expected to be widely applied in the fields of organic synthesis, drug development, high polymer materials and the like.
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