A non-contact nasopharyngeal tissue stiffness measuring endoscope

By integrating a non-contact mechanical excitation and optical observation module into the tip of the nasal endoscope probe, the problem of measuring stiffness in the narrow nasopharyngeal passage was solved, enabling visualized biopsy for early diagnosis of nasopharyngeal carcinoma and improving diagnostic accuracy and operational efficiency.

CN122250907APending Publication Date: 2026-06-23SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Filing Date
2026-05-26
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

Current technology lacks non-contact nasopharyngeal tissue stiffness measurement equipment, making it impossible to achieve real-time, non-invasive stiffness measurement in the narrow and tortuous nasopharyngeal passages, which leads to difficulties in early diagnosis of nasopharyngeal carcinoma and a high rate of missed diagnoses.

Method used

A non-contact nasal endoscope for measuring nasopharyngeal tissue stiffness is designed. It integrates a non-contact mechanical excitation module, an optical observation module, and a micro-displacement detection module at the front end of the probe body. It adopts a hemispherical multi-hole micro-nozzle and a snap-fit ​​assembly to achieve airflow excitation and stiffness measurement, avoiding direct contact with the nasopharyngeal mucosa.

Benefits of technology

It enables comprehensive measurement of nasopharyngeal mucosal stiffness without blind spots, significantly improving the positive rate of biopsy, reducing the false negative rate of pathology, enhancing diagnostic suitability and ease of operation, and ensuring the repeatability and accuracy of measurement.

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Abstract

The application discloses a non-contact nasopharyngeal tissue hardness measuring endoscope, and relates to the technical field of nasopharyngeal detection equipment. The non-contact nasopharyngeal tissue hardness measuring endoscope comprises an endoscope body, a probe body and a host control unit; the probe body is an elongated instrument capable of entering the nasopharynx through the nasal cavity, and an optical observation module and a micro-displacement detection module are coaxially integrated on the front end of the probe body in the axial direction; the non-contact mechanical excitation module further comprises a hemispherical porous micro-nozzle and an excitation control unit; the hemispherical porous micro-nozzle is rotatably buckled with the front end of the probe body; the micro-nozzle comprises a hemisphere, the micro-displacement detection module is axially inserted into the middle part of the hemisphere; a spherical shell-shaped air groove is formed in the interior of the hemisphere, and a micro-pore communicating with the air groove is formed on the spherical surface of the hemisphere; the micro-pores are arranged in an annular layered and optical axis staggered manner, so that the biopsy positive rate is significantly improved, the pathological false negative rate is reduced, and the clinical diagnosis adaptability is improved.
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Description

Technical Field

[0001] This invention relates to the field of nasopharyngeal testing equipment technology, specifically a non-contact nasopharyngeal tissue stiffness measuring nasal endoscope. Background Technology

[0002] Nasopharyngeal carcinoma is characterized by its insidious early stages and rapid progression, and the early diagnosis rate directly determines the patient's prognosis: the 5-year survival rate for stage I / II nasopharyngeal carcinoma exceeds 90%, while that for advanced stages is less than 50%. The current core clinical diagnostic model relies on routine endoscopic morphological observation and empirical biopsy, which faces two major bottlenecks: First, early cancerous changes may only manifest as abnormal mucosal color, roughness, or slight protrusion, highly similar to inflammation or hyperplasia, relying entirely on the physician's subjective judgment, leading to a high rate of missed diagnoses of small lesions; second, biopsy lacks objective target guidance, making sampling errors and superficial sampling common in submucosal invasive carcinoma and diffusely bordered lesions, resulting in false negatives and delayed treatment.

[0003] Tissue stiffness (elastic modulus) is an objective physical marker for differentiating between benign and malignant lesions: malignant tumors have significantly higher stiffness than normal mucosa and benign tissues due to their dense cell density and interstitial collagen remodeling, which can be quantitatively distinguished.

[0004] Existing tissue stiffness testing technologies have significant limitations in nasopharyngeal diagnosis and treatment: contact testing (such as ultrasound elastography and mechanical probes) requires direct compression of the mucosa, which can easily lead to bleeding and damage; it cannot be adapted to the narrow and tortuous passages of the nasopharynx; it is difficult to integrate with nasal endoscopes; and it cannot achieve real-time intraoperative navigation. Non-contact optical testing (such as OCT and laser speckle) is costly, easily affected by secretions, and cannot provide direct mechanical excitation, resulting in insufficient accuracy in hardness measurement. In summary, existing technologies lack a non-contact nasopharyngeal endoscope for measuring nasopharyngeal tissue stiffness. To address these clinical challenges and technological gaps, this invention was developed. Summary of the Invention

[0005] The purpose of this invention is to provide a non-contact nasopharyngeal tissue stiffness measurement nasal endoscope to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a non-contact nasopharyngeal tissue stiffness measuring nasal endoscope, comprising an endoscope body, a probe body, and a main unit control unit; The probe body is a slender instrument that can enter the nasopharynx through the nasal cavity, and its front end is coaxially integrated with an optical observation module and a micro-displacement detection module. It also includes a non-contact mechanical excitation module; the non-contact mechanical excitation module includes a hemispherical porous micro-nozzle and an excitation control unit; The hemispherical porous micro-nozzle is rotated and snapped to the front end of the probe body; The micro-nozzle includes a hemisphere, with a movable insert micro-displacement detection module axially penetrating the center of the hemisphere; a spherical air groove is formed inside the hemisphere, and micro-holes communicating with the air groove are formed on the spherical surface of the hemisphere. The micro-holes are arranged in a ring-layered and offset manner to avoid the line of sight of the optical observation module and cover its core observation area. The probe body is fitted with a cylindrical mechanism, and an air transmission unit is formed between the probe body and the cylindrical mechanism; the cylindrical mechanism includes an auxiliary protection unit and a snap-fit ​​assembly; The air transmission unit connects the hemispherical porous micro nozzle to the main control unit; The auxiliary protection unit is integrated into the gas transmission unit and is used to achieve anti-blocking and pressure protection; The excitation control unit is electrically connected to the air transmission unit and is used to control the pulse airflow with adjustable output parameters.

[0007] As a preferred embodiment of the present invention, the surface of the hemispherical porous micro-nozzle is treated with anti-reflection; A U-shaped buckle is fixedly connected to the outer end face of the hemisphere; the surface of the buckle is provided with anti-slip texture. The buckle assembly includes a steel cylinder, and a U-shaped buckle groove is opened at the front end of the steel cylinder corresponding to the buckle; a sealing groove is opened on the outer side of the steel cylinder, which connects to the rear side of the buckle groove, and a sealing ring is provided in the sealing groove. The hemispherical multi-hole micro-nozzle is locked by clockwise rotation and disassembled by counterclockwise rotation; The outer side of the rigid cylinder is provided with a knife groove that crosses the sealing groove; The inner side of the rigid cylinder is provided with an external groove.

[0008] As a preferred embodiment of the present invention, the probe body includes a steel pipe, and an internal groove is provided in the middle of the front end of the steel pipe; The front end of the steel pipe is provided with an inner groove corresponding to the outer groove. Pipe pits are evenly spaced and cut on the outer side of the steel pipe.

[0009] As a preferred embodiment of the present invention, the optical observation module includes an image sensor, a cold light source, and slots; the image sensor is embedded in the middle of the rear inner wall of the built-in slot, and the cold light source is embedded in the rear inner wall of the built-in slot and arranged in a ring around the image sensor; slots are provided at the four corners of the rear inner wall of the built-in slot.

[0010] As a preferred embodiment of the present invention, the auxiliary support unit includes a flexible cylinder that connects to the rigid cylinder, a sealing cylinder that is fixedly connected to the rear end of the flexible cylinder, and the sealing cylinder is fixedly sleeved and seals the steel pipe; the lower side of the sealing cylinder is fixedly connected to an air inlet valve that connects to the host control unit. The inner side of the flexible cylinder is fixedly connected with auxiliary pipes that are adapted to the insertion pits at equal intervals.

[0011] As a preferred embodiment of the present invention, the gas transmission unit includes a microchannel, a connecting component, and a filtration and drying assembly; The microchannel is the space formed between the steel tube and the flexible tube, and the microchannel is isolated from the circuit channel inside the probe body; auxiliary tubes are adapted and distributed inside the microchannel; The filtration and drying assembly includes a micro-filter built into the microchannel near the end of the hemispherical porous micro-nozzle, and a drying unit built into the end near the main control unit.

[0012] As a preferred embodiment of the present invention, the micro-displacement detection module includes a detection cylinder that is movably connected to a hemisphere via a bearing. Displacement identifiers that are equidistantly and uniformly fixed to the inner side of the front end of the detection cylinder are interposed with the cold light source. The rear end of the detection cylinder is adapted to be inserted into an internal slot and is fixedly connected to a rod, which corresponds to a slot for insertion.

[0013] As a preferred embodiment of the present invention, the rear end of the air groove is connected to a ring tube corresponding to the microchannel, the inner wall of the ring tube corresponds to the inner groove of the insertion tube, and the outer wall of the ring tube corresponds to the outer groove of the insertion tube. The outer side of the annular tube is fitted with a first sealing gasket with an insert buckle, and the first sealing gasket is in contact with the steel cylinder; a second sealing gasket is provided between the annular tube and the detection cylinder, and the second sealing gasket is in contact with the steel pipe; both the first sealing gasket and the second sealing gasket are fixedly connected to the end face of the hemisphere. The hemisphere has alignment lines corresponding to the tool grooves on its curved edge.

[0014] As a preferred embodiment of the present invention, the endoscope body includes a handle, an eyepiece is integrated at the rear end of the handle, a light guide connector is integrated at the lower side of the handle, and an endoscope connector for docking the probe body and the barrel mechanism is integrated at the front end of the handle.

[0015] Compared with the prior art, the beneficial effects of the present invention are: (1) A non-contact nasopharyngeal tissue hardness measurement nasal endoscope, wherein the non-contact mechanical excitation module, optical observation module and micro-displacement detection module are coaxially integrated at the front end of the probe body, and the external size and operation path are fully compatible with conventional nasal endoscopes without changing clinical operation habits; real-time hardness and optical morphology are fused and displayed, which can intuitively mark high hardness suspicious target areas, upgrade the traditional empirical blind biopsy to visualized hardness targeted biopsy, significantly improve the biopsy positive rate, reduce the pathological false negative rate, and improve the clinical diagnostic suitability.

[0016] (2) A non-contact nasopharyngeal tissue hardness measurement nasal endoscope, wherein the micropores on the hemispherical multi-hole micro nozzle are arranged in a ring-layered and visual axis misalignment manner, which allows the pulsed airflow to completely cover the core visual axis area of ​​the optical observation module. At the same time, the detection tube of the micro-displacement detection module completely avoids the lens optical path, so that the optical observation module has no field of view obstruction. With the synchronous linkage of diffused airflow excitation and micro-displacement detection module, the morphological observation of the nasopharyngeal mucosa and the emission of air pulsed airflow can be realized. Finally, the deformation detection is performed through the micro-displacement detection module to ensure that the hardness measurement of the nasopharyngeal mucosa is carried out without dead angles.

[0017] (3) A non-contact nasopharyngeal tissue hardness measuring nasal endoscope, wherein the alignment line of the micro-nozzle is aligned with the knife groove of the cylindrical mechanism surrounding the probe body, and the buckle of the micro-nozzle is inserted into the wide side of the buckle groove. The micro-nozzle is pushed backward to squeeze the first sealing pad and the second sealing pad. Then, the buckle is screwed into the narrow side of the buckle groove by rotating clockwise. Then, the first sealing pad and the second sealing pad are locked by the rebound of the first sealing pad and the second sealing pad. A sealing groove is opened on the outer side of the cylindrical body to connect the rear side of the buckle groove. The sealing ring is put into the sealing groove from the micro-nozzle. The sealing ring abuts against the buckle from the rear side, thereby sealing and locking the micro-nozzle and improving the connection sealing performance.

[0018] (4) A non-contact nasopharyngeal tissue hardness measuring nasal endoscope, when disassembling, first cut the sealing ring by inserting a tool into the knife groove. At this time, the back side of the buckle is empty. Then push the micro nozzle to squeeze the first sealing pad and the second sealing pad. Then rotate counterclockwise to disassemble. The operation is convenient and efficient, greatly improving the efficiency of clinical cleaning, sterilization and maintenance.

[0019] (5) A non-contact nasopharyngeal tissue hardness measurement nasal endoscope with a snap-fit ​​and a groove that fits precisely, and is sealed by the compression of the sealing ring, the first sealing pad and the second sealing pad, reducing the gap between the micro-nozzle and the probe body, achieving a completely sealed air path without leakage, ensuring stable and controllable pulse excitation pressure, and significantly improving the repeatability and accuracy of hardness measurement.

[0020] (6) A non-contact nasopharyngeal tissue hardness measuring nasal endoscope, wherein the micro-spray head and the probe body are connected by a snap-fit ​​assembly and a first sealing pad, so that there are no protrusions or sharp edges at the connection point. With the hemispherical porous micro-spray head, the stimulation to the nasal mucosa can be reduced. Through the setting of the first sealing pad and the second sealing pad, when the probe body is inserted into the patient's nasopharynx, the buffer when the micro-spray head contacts the nasal mucosa can be increased, and the protection of the nasopharyngeal mucosa during insertion can be improved. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the endoscope body of the present invention; Figure 2 This is a schematic diagram of the cylindrical body mechanism of the present invention; Figure 3 This is a schematic diagram of the probe body of the present invention; Figure 4 This is a schematic diagram of the optical observation module of the present invention; Figure 5 This is a schematic diagram of the auxiliary protection unit of the present invention; Figure 6 This is a schematic diagram of the snap-fit ​​assembly of the present invention; Figure 7 This is a schematic diagram of the front end of the micro-nozzle of the present invention; Figure 8 This is a schematic diagram of the rear end of the micro-nozzle of the present invention; Figure 9 This is a schematic diagram illustrating the release of the buckle in this invention; Figure 10 This is a schematic diagram of the buckle locking mechanism of the present invention; Figure 11 This is a schematic diagram of the interior of the micro-nozzle of the present invention; Figure 12 This is a schematic diagram of the ring pipe connection of the present invention; Figure 13 This is a schematic diagram of the docking of the micro-displacement detection module of the present invention.

[0022] In the diagram: 1. Endoscope body; 101. Handle; 102. Eyepiece; 103. Light guide connector; 104. Endoscope connector; 2. Probe body; 201. Steel tube; 202. Internal groove; 203. Tube groove; 204. Tube recess; 205. Image sensor; 206. Cold light source; 207. Slot; 3. Cylinder mechanism; 301. Flexible tube; 302. Sealing tube; 303. Gas valve; 304. Auxiliary tube 305. Rigid cylinder; 306. Snap groove; 307. Sealing groove; 308. Knife groove; 309. Sealing ring; 310. External groove of pipe; 4. Micro nozzle; 401. Hemisphere; 402. Detection cylinder; 403. Displacement identifier; 404. Insert rod; 405. Air groove; 406. Micropore; 407. Ring pipe; 408. First sealing gasket; 409. Second sealing gasket; 410. Alignment line; 411. Snap fastener. Detailed Implementation

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Example: Please refer to Figures 1-13 A non-contact nasopharyngeal tissue stiffness measurement nasal endoscope, comprising an endoscope body 1, a probe body 2, and a main unit control unit; The probe body 2 is a slender instrument that can enter the nasopharynx through the nasal cavity, and its front end is coaxially integrated with an optical observation module and a micro-displacement detection module. It also includes a non-contact mechanical excitation module; the non-contact mechanical excitation module includes a hemispherical porous micro-nozzle 4 and an excitation control unit; The hemispherical porous micro-nozzle 4 is connected to the front end of the probe body 2 by a rotating snap-fit. The micro-nozzle 4 includes a hemisphere 401, through which a movable micro-displacement detection module is axially inserted; a spherical air groove 405 is formed inside the hemisphere 401, and a micro-hole 406 communicating with the air groove 405 is formed on the spherical surface of the hemisphere 401. The micro-holes 406 are arranged in a ring-layered and staggered manner to avoid the line of sight of the optical observation module and cover its core observation area. The probe body 2 is fitted with a cylindrical mechanism 3, and a gas transmission unit is formed between the probe body 2 and the cylindrical mechanism 3; the cylindrical mechanism 3 includes an auxiliary protection unit and a snap-fit ​​assembly; The air transmission unit connects the hemispherical multi-hole micro nozzle 4 to the main control unit; The auxiliary protection unit is integrated into the gas transmission unit to achieve anti-clogging and pressure protection; The excitation control unit is electrically connected to the air transmission unit and is used to control the pulsed airflow with adjustable output parameters.

[0025] The surface of the hemispherical porous micro-nozzle 4 is treated with anti-reflection coating; A U-shaped buckle 411 is fixedly connected to the outer side of the end face of the hemisphere 401; the surface of the buckle 411 is provided with anti-slip texture; The buckle assembly includes a steel cylinder 305, and a U-shaped buckle groove 306 is provided at the front end of the steel cylinder 305 corresponding to the buckle 411; a sealing groove 307 is provided on the outer side of the steel cylinder 305 to connect the rear side of the buckle groove 306, and a sealing ring 309 is provided in the sealing groove 307. The hemispherical multi-hole micro-nozzle 4 is locked by clockwise rotation and disassembled by counterclockwise rotation; A knife groove 308 that crosses the sealing groove 307 is provided on the outer side of the rigid cylinder 305; The inner side of the rigid cylinder 305 is provided with an external groove 310.

[0026] The probe body 2 includes a steel pipe 201, and an internal groove 202 is provided in the middle of the front end of the steel pipe 201; The outer front end of the steel pipe 201 is provided with an inner groove 203 corresponding to the outer groove 310; Pipe pits 204 are evenly spaced on the outer side of the steel pipe 201.

[0027] The optical observation module includes an image sensor 205, a cold light source 206, and slots 207. The image sensor 205 is embedded in the middle of the rear inner wall of the built-in slot 202, and the cold light source 206 is embedded in the rear inner wall of the built-in slot 202 and arranged in a ring around the image sensor 205. Slots 207 are provided at the four corners of the rear inner wall of the built-in slot 202.

[0028] The auxiliary support unit includes a flexible cylinder 301 that connects to the rigid cylinder 305. A sealing cylinder 302 is fixedly connected to the rear end of the flexible cylinder 301. The sealing cylinder 302 is fixedly sleeved and seals the steel pipe 201. An air inlet valve 303 that connects to the main unit control unit is fixedly connected to the lower side of the sealing cylinder 302. The inner side of the flexible tube 301 is fixedly connected with auxiliary tubes 304 that are adapted to the insertion pits 204 at equal intervals.

[0029] The gas transmission unit includes microchannels, connecting components, and a filter and drying assembly; The microchannel is the space formed between the steel tube 201 and the flexible tube 301. The microchannel is isolated from the circuit channel inside the probe body 2. The auxiliary tube 304 is adapted and distributed inside the microchannel to enhance the support strength of the flexible tube 301, while the flexible tube 301 gently contacts the patient's nasopharynx. The filtration and drying assembly includes a micro-filter built into the microchannel near the hemispherical porous micro-nozzle 4, and a drying unit built into the main control unit.

[0030] The micro-displacement detection module includes a detection cylinder 402 that is movably connected to a hemisphere 401 via a bearing. Displacement identifiers 403, which are interspersed with cold light source 206, are fixedly connected at equal intervals on the inner side of the front end of the detection cylinder 402. The rear end of the detection cylinder 402 is adapted to be inserted into the built-in slot 202 and is fixedly connected to a rod 404, which corresponds to the insertion slot 207. The excitation control unit supports both manual and automatic triggering modes. In automatic triggering mode, it is linked with the optical observation module. When a suspicious morphological area of ​​the nasopharyngeal mucosa is detected, it automatically starts pulsed airflow excitation and simultaneously triggers the micro-displacement detection module.

[0031] The rear end of the air groove 405 is connected to a ring tube 407 corresponding to the microchannel. The inner wall of the ring tube 407 corresponds to the inner groove 203 of the insertion tube, and the outer wall of the ring tube 407 corresponds to the outer groove 310 of the insertion tube. A first sealing gasket 408 with an insert buckle 411 is fitted on the outer side of the annular tube 407, and the first sealing gasket 408 fits against the steel cylinder 305; a second sealing gasket 409 is provided between the annular tube 407 and the detection cylinder 402, and the second sealing gasket 409 fits against the steel pipe 201; both the first sealing gasket 408 and the second sealing gasket 409 are fixedly connected to the end face of the hemisphere 401. The curved edge of the hemisphere 401 is provided with a corresponding alignment line 410 for the tool groove 308.

[0032] The endoscope body 1 includes a handle 101, an eyepiece 102 is integrated at the rear end of the handle 101, a light guide connector 103 is integrated at the lower side of the handle 101, and an endoscope connector 104 for docking the probe body 2 and the barrel mechanism 3 is integrated at the front end of the handle 101.

[0033] The working principle of this invention is as follows: The micro-holes 406 on the hemispherical porous micro-nozzle 4 are arranged in a ring-shaped layered and staggered manner, which allows the pulsed airflow to completely cover the core visual axis area of ​​the optical observation module. At the same time, the detection cylinder 402 of the micro-displacement detection module completely avoids the lens optical path, so that the optical observation module has no field of view obstruction. With the synchronous linkage of diffused airflow excitation and micro-displacement detection module, the morphological observation of the nasopharyngeal mucosa and the emission of air pulse airflow can be realized. Finally, the deformation detection module is used to detect deformation, ensuring that the hardness measurement of the nasopharyngeal mucosa is carried out without dead angles.

[0034] The hemispherical multi-hole micro-nozzle 4 and the front end of the probe body 2 are rotated and snapped together, which is suitable for the miniaturization, aseptic operation and rapid maintenance of nasal endoscopes. The alignment line 410 of the micro-nozzle 4 is aligned with the knife groove 308 of the outer cylindrical mechanism 3 of the probe body 2. At this time, the snap 411 of the micro-nozzle 4 is inserted into the wide side of the snap groove 306. Pushing the micro-nozzle 4 backward squeezes the first sealing gasket 408 and the second sealing gasket 409. Then, rotating clockwise can screw the snap 411 into the narrow side of the snap groove 306. Then, the first sealing gasket 408 and the second sealing gasket 409 are locked by their rebound. The outer side of the cylindrical tube 305 has a sealing groove 307 that connects to the rear side of the snap groove 306. The sealing ring 309 is put into the sealing groove 307 from the micro-nozzle 4. The sealing ring 309 abuts against the snap 411 from the rear side, thereby sealing and locking the micro-nozzle 4 and improving the connection sealing performance.

[0035] During disassembly, first use a tool to cut the sealing ring 309 by inserting it into the knife groove 308. At this time, the back side of the buckle 411 is free. Then push the micro-nozzle 4 to squeeze the first sealing gasket 408 and the second sealing gasket 409. Then rotate counterclockwise to disassemble. The operation is convenient and efficient, greatly improving the efficiency of clinical cleaning, sterilization and maintenance.

[0036] The snap fastener 411 and the snap groove 306 engage precisely, and together with the sealing ring 309, the first sealing gasket 408 and the second sealing gasket 409, they press and seal, reducing the gap between the micro nozzle 4 and the probe body 2, achieving a completely sealed and leak-free air path, ensuring stable and controllable pulse excitation pressure, and significantly improving the repeatability and accuracy of hardness measurement.

[0037] The micro-nozzle 4 and the probe body 2 are engaged by the snap-fit ​​assembly of 003 and the first sealing gasket 408, so that there are no protrusions or sharp edges at the joint. With the hemispherical porous micro-nozzle 4, the irritation to the nasal mucosa can be reduced. The setting of the first sealing gasket 408 and the second sealing gasket 409 can increase the buffer when the probe body 2 is inserted into the patient's nasopharynx, and improve the protection of the nasopharyngeal mucosa during insertion.

[0038] The non-contact mechanical excitation module, optical observation module, and micro-displacement detection module are coaxially integrated at the front end of the probe body 2. The shape and operation path are fully compatible with conventional nasal endoscopes, without changing clinical operating habits. The real-time hardness and optical morphology are fused and displayed, which can intuitively mark high-hardness suspicious target areas. This upgrades the traditional empirical blind biopsy to a visualized hardness-targeted biopsy, significantly improving the biopsy positive rate, reducing the pathological false negative rate, and improving the clinical diagnostic suitability.

[0039] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A non-contact nasopharyngeal tissue stiffness measurement nasal endoscope, comprising an endoscope body (1), a probe body (2), and a main unit control unit; The probe body (2) is a slender instrument that can enter the nasopharynx through the nasal cavity, and its front end is coaxially integrated with an optical observation module and a micro-displacement detection module. characterized in that It also includes a non-contact mechanical excitation module; the non-contact mechanical excitation module includes a hemispherical porous micro-nozzle (4) and an excitation control unit; The hemispherical porous micro-nozzle (4) is rotated and snapped to the front end of the probe body (2); The micro-nozzle (4) includes a hemisphere (401), through which a movable micro-displacement detection module is axially inserted; a spherical air groove (405) is formed inside the hemisphere (401), and a micro-hole (406) communicating with the air groove (405) is formed on the spherical surface of the hemisphere (401). The micro-hole (406) is arranged in a ring-layered and offset manner to avoid the optical observation module's visual axis and cover its core observation area. The probe body (2) is covered with a cylindrical mechanism (3), and an air transmission unit is formed between the probe body (2) and the cylindrical mechanism (3); the cylindrical mechanism (3) includes an auxiliary protection unit and a snap-fit ​​assembly; The air transmission unit connects the hemispherical porous micro nozzle (4) to the main control unit; The auxiliary protection unit is integrated into the gas transmission unit and is used to achieve anti-blocking and pressure protection; The excitation control unit is electrically connected to the air transmission unit and is used to control the pulse airflow with adjustable output parameters.

2. A non-contact nasopharyngeal tissue stiffness measuring endoscope according to claim 1, wherein: The surface of the hemispherical porous micro-nozzle (4) is treated with anti-reflection coating; A U-shaped buckle (411) is fixedly connected to the outer side of the end face of the hemisphere (401); the surface of the buckle (411) is provided with anti-slip texture; The buckle assembly includes a steel cylinder (305), and a U-shaped buckle groove (306) is provided at the front end of the steel cylinder (305) corresponding to the buckle (411); a sealing groove (307) is provided on the outer side of the steel cylinder (305) to connect the rear side of the buckle groove (306), and a sealing ring (309) is provided in the sealing groove (307). The hemispherical porous micro-nozzle (4) is locked by clockwise rotation and disassembled by counterclockwise rotation; The outer side of the steel cylinder (305) is provided with a knife groove (308) that crosses the sealing groove (307); The inner side of the steel cylinder (305) is provided with an outer groove (310).

3. A non-contact nasopharyngeal tissue stiffness measuring endoscope according to claim 2, wherein: The probe body (2) includes a steel pipe (201), and an internal groove (202) is provided in the middle of the front end of the steel pipe (201). The front end of the steel pipe (201) is provided with an inner groove (203) corresponding to the outer groove (310); Pipe pits (204) are evenly spaced on the outer side of the steel pipe (201).

4. The non-contact nasopharyngeal tissue stiffness measuring endoscope according to claim 3, wherein: The optical observation module includes an image sensor (205), a cold light source (206), and slots (207); the image sensor (205) is embedded in the middle of the rear inner wall of the built-in slot (202), and the cold light source (206) is embedded on the rear inner wall of the built-in slot (202) and arranged in a ring around the image sensor (205); slots (207) are provided at the four corners of the rear inner wall of the built-in slot (202).

5. A non-contact nasopharyngeal tissue stiffness measuring endoscope according to claim 4, wherein: The auxiliary support unit includes a flexible cylinder (301) that connects to the rigid cylinder (305). A sealing cylinder (302) is fixedly connected to the rear end of the flexible cylinder (301). The sealing cylinder (302) is fixedly sleeved and seals the steel pipe (201). An air inlet valve (303) for docking with the host control unit is fixedly connected to the lower side of the sealing cylinder (302). The inner side of the flexible tube (301) is fixedly connected with auxiliary tubes (304) that are adapted to the insertion pits (204).

6. The non-contact nasopharyngeal tissue stiffness measurement nasal endoscope according to claim 5, characterized in that: The gas transmission unit includes a microchannel, connecting components, and a filter and drying assembly. The microchannel is the space formed between the steel tube (201) and the flexible tube (301), and the microchannel is isolated from the circuit channel inside the probe body (2); the microchannel is fitted with an auxiliary tube (304). The filtration and drying assembly includes a micro-filter built into the end of the microchannel near the hemispherical porous micro-nozzle (4) and a drying unit built into the end near the host control unit.

7. The non-contact nasopharyngeal tissue stiffness measurement nasal endoscope according to claim 6, characterized in that: The micro-displacement detection module includes a detection cylinder (402) that is movably connected to a hemisphere (401) via a bearing. Displacement identifiers (403) that are equidistantly and uniformly fixed to the inner side of the front end of the detection cylinder (402) are interposed with the cold light source (206). The rear end of the detection cylinder (402) is adapted to be inserted into the built-in slot (202) and is fixedly connected to a plug rod (404). The plug rod (404) corresponds to the insertion slot (207).

8. A non-contact nasopharyngeal tissue stiffness measurement nasal endoscope according to claim 7, characterized in that: The rear end of the air groove (405) is connected to a ring tube (407) corresponding to the microchannel. The inner wall of the ring tube (407) corresponds to the inner groove of the insertion tube (203), and the outer wall of the ring tube (407) corresponds to the outer groove of the insertion tube (310). The outer side of the annular tube (407) is fitted with a first sealing gasket (408) with a through buckle (411), and the first sealing gasket (408) fits against the steel cylinder (305); a second sealing gasket (409) is provided between the annular tube (407) and the detection cylinder (402), and the second sealing gasket (409) fits against the steel pipe (201); the first sealing gasket (408) and the second sealing gasket (409) are both fixedly connected to the end face of the hemisphere (401); The hemisphere (401) has a corresponding alignment line (410) on its arc edge.

9. A non-contact nasopharyngeal tissue stiffness measurement nasal endoscope according to claim 1, characterized in that: The endoscope body (1) includes a handle (101), an eyepiece (102) is integrated at the rear end of the handle (101), a light guide connector (103) is integrated on the lower side of the handle (101), and an endoscope connector (104) for docking the probe body (2) and the cylinder mechanism (3) is integrated at the front end of the handle (101).