Antibacterial polypeptide and application thereof in pharmacy
By replacing amino acids in the template peptide raniseptinPL to form a staple peptide, the problem of its resistance to enterococci was solved, and the antibacterial performance against a variety of bacteria, especially enterococci, was significantly improved, achieving more efficient antibacterial activity.
Patent Information
- Application Number
- CN202610404926.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-29
- Publication Date
- 2026-06-23
AI Technical Summary
The problem of resistance to Enterococcus by existing antimicrobial peptides such as raniseptin PL has not been effectively solved, and they are easily hydrolyzed by enzymes, resulting in limited antimicrobial activity, which hinders their development into new antibiotics.
By replacing amino acid residues in the template peptide raniseptinPL, and using Rink amide MBHA amino resin as a solid support, the original amino acids were replaced with S5 and R8 at positions i, i+4 and i, i+7, respectively, to form a stapling peptide, which improves conformational stability and anti-drug-resistant bacterial activity.
It significantly improved the antibacterial properties of staple peptides against a variety of bacteria, especially against enterococci. The antibacterial properties of some staple peptides against enterococci were increased by 3-31 times, and the antibacterial effects against Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis were enhanced.