Novel organic photothermals for photothermal therapy and compositions comprising the same

By introducing a novel coumarin-based organic photothermal agent with a strong stretching vibration receptor and a free-rotating rotor design, the problems of biodegradability and low conversion efficiency of existing photothermal agents are solved, achieving a highly efficient photothermal therapy effect, which is particularly suitable for cancer treatment.

CN122355995APending Publication Date: 2026-07-10PUKYONG NAT UNIV IND ACADEMIC COOPERATION FOUND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PUKYONG NAT UNIV IND ACADEMIC COOPERATION FOUND
Filing Date
2025-12-24
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Existing inorganic photothermal agents have limited clinical applications due to their low biodegradability and long-term toxicity, while the photothermal conversion efficiency of existing organic photothermal agents needs to be improved, making them unable to effectively target and treat cancer cells.

Method used

A novel organic photothermal agent based on coumarin is designed, incorporating a strongly stretching vibration receptor (1,3-bis(dicyanomethylene)indane) and a free-rotating rotor (such as -CF3 rotor) to improve photothermal conversion efficiency and effectively convert light energy into heat energy for photothermal therapy.

Benefits of technology

It achieves high photothermal conversion efficiency, is suitable for high cell penetration of near-infrared light, is suitable for photothermal therapy, especially cancer treatment, and has low side effects.

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Abstract

This invention relates to a novel organic photothermal agent for photothermal therapy and a composition comprising the same, and more specifically, to an organic photothermal agent represented by the following formula 1 and a composition comprising the same: [Formula 1]; wherein: R 1 To R 6 Each of them is selected from hydrogen, halogen, straight-chain or branched alkyl groups having 1 to 10 carbon atoms, alkenyl groups having 2 to 10 carbon atoms, alkynyl groups having 2 to 10 carbon atoms, and haloalkyl groups having 1 to 10 carbon atoms.
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