3-bromo-2-methyl-n-phenyl-2-(p-tolyl)propionamide compound, a synthetic method thereof and application thereof in preparation of antitumor drugs

The synthesis of 3-bromo-2-methyl-N-phenyl-2-(p-tolyl)propionamide compounds via bromination/Truce–Smiles rearrangement/desulfonation tandem reaction solves the problem of poor inhibitory effect on human choroidal melanoma cells in existing technologies, and realizes significant prospects for the development of anti-tumor drugs.

CN122404178APending Publication Date: 2026-07-17HUNAN CHEM VOCATIONAL TECH COLLEGE
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUNAN CHEM VOCATIONAL TECH COLLEGE
Filing Date
2026-04-27
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Current technologies lack effective drugs to inhibit melanoma cells in the human choroid, especially commercially available drugs such as 5-fluorouracil, which have limited efficacy and cannot meet clinical needs.

Method used

Using commercially available and inexpensive N-arylsulfonylacrylamide as the amide group source, 3-bromo-2-methyl-N-phenyl-2-(p-tolyl)propionamide compounds were synthesized in one step via a bromination/Truce–Smiles rearrangement/desulfonation tandem reaction for the preparation of antitumor drugs.

Benefits of technology

The synthesized 3-bromo-2-methyl-N-phenyl-2-(p-tolyl)propionamide compounds showed significant inhibitory activity against human choroidal melanoma cells, even superior to existing drugs, and are suitable for large-scale production.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122404178A_ABST
    Figure CN122404178A_ABST
Patent Text Reader

Abstract

本发明公开了一种3‑溴‑2‑甲基‑N‑苯基‑2‑(对甲苯基)丙酰胺类化合物及其合成方法和在制备抗肿瘤药物中的应用，属于药物合成技术领域。3‑溴‑2‑甲基‑N‑苯基‑2‑(对甲苯基)丙酰胺类化合物的结构式如下：，其中，R为取代基；该类化合物对人眼脉络膜黑色素瘤细胞具有显著抑制作用，且抑制活性优于现有的商业化5‑氟尿嘧啶，为新抗人眼脉络膜黑色素瘤药物的开发提供了新的先导化合物。
Need to check novelty before this filing date? Find Prior Art