An oocyte viscoelasticity characterization method, device, medium and product based on a nonlinear Maxwell model

By constructing a viscoelastic characterization method for oocytes based on the nonlinear Maxwell model and optimizing parameters using the differential evolution algorithm, the problem that traditional models cannot describe the nonlinear viscoelastic behavior of shellfish oocytes is solved. This achieves accurate model fitting and universal description, and reduces the risk of cell manipulation damage.

CN122455075APending Publication Date: 2026-07-24HAINAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HAINAN UNIV
Filing Date
2026-05-08
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing traditional viscoelastic models cannot accurately describe the nonlinear viscoelastic behavior of shellfish oocytes and lack universality, making it difficult to provide effective guidance for oocyte manipulation in assisted reproductive technologies.

Method used

Using a nonlinear Maxwell model, force-time curve samples were obtained through constant-velocity indentation experiments with multiple velocity groups. A Maxwell model with nonlinear exponential parameters was constructed, and the unified parameters were optimized using a differential evolution global optimization algorithm. With the goal of maximizing the minimum coefficient of determination, an accurate description of the viscoelastic behavior of mollusk egg cells was achieved.

Benefits of technology

This study achieves an accurate and universal description of the nonlinear viscoelastic behavior of shellfish oocytes, improves the reliability of model fitting, reduces the risk of damage during cell manipulation, and provides a theoretical basis for manipulation techniques such as microinjection.

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Abstract

The application discloses a method and device for characterizing the viscoelasticity of an egg cell based on a nonlinear Maxwell model, a medium and a product, and relates to the field of the viscoelasticity of an egg cell. The method acquires a force-time curve sample set of a shellfish egg cell; a Maxwell model with a nonlinear index parameter is constructed; according to the force-time curve sample set, a differential evolution global optimization algorithm is used to optimize a unified parameter in the Maxwell model, with the maximum minimum determination coefficient in all samples as an optimization target, so that the optimized unified parameter is obtained; the Maxwell model with the optimized unified parameter is fitted and verified, so that it is determined that all samples reach a fitting standard, and a verified Maxwell model is obtained; and the verified Maxwell model is used to describe the nonlinear viscoelastic behavior of the shellfish egg cell. The application can accurately and universally describe the viscoelastic mechanical behavior of the shellfish egg cell.
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