A novel high-efficiency bactericide and its preparation method

By preparing a novel and highly efficient bactericide containing quaternary ammonium salts, quaternary phosphorus salts, and metallic silver ions, and utilizing electrostatic interactions and hydrophobic chains to insert into bacterial cell membranes, combining silver ions with membrane proteins, the problem of poor antibacterial effects of rosin-based quaternary ammonium salts was solved, achieving highly efficient bactericidal effects against a variety of bacteria.

CN122628090APending Publication Date: 2026-08-25DALIAN ECONOMY & TECH DEV ZONE LIJIA CHEM PRODS
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Patent Information

Application Number
CN202610547605.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-23
Publication Date
2026-08-25

AI Technical Summary

Technical Problem

The existing antibacterial effects of rosin-based quaternary ammonium salts are biased and their antibacterial spectrum is narrow, resulting in poor performance in practical applications.

Method used

A novel, highly efficient bactericide containing quaternary ammonium salt, quaternary phosphonium salt, and metallic silver ions was prepared by reacting a compound of maleic pine carboxylic acid quaternary ammonium hydrochloride with (2-hydroxyethyl)triphenylphosphonium chloride and silver citrate in a solvent. The bactericide utilizes electrostatic interaction and hydrophobic chains to insert into the bacterial cell membrane, disrupting the cell's osmotic pressure balance, and exerts its antibacterial effect by binding silver ions to membrane proteins.

Benefits of technology

The newly prepared highly efficient bactericide has an antibacterial rate of over 98% against Escherichia coli, Staphylococcus aureus and Bacillus subtilis, significantly improving the antibacterial effect. In particular, it has a unique penetrating ability against Bacillus subtilis spores.

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Abstract

This invention relates to a novel, highly efficient bactericide and its preparation method, belonging to the field of antibacterial materials technology. The invention utilizes the reaction of epoxy groups and tertiary amine compounds in maleic pine carboxylic acid glyceride under hydrochloric acid to convert the epoxy groups into a hydroxyl quaternary ammonium salt structure. Then, an esterification reaction between trimellitic anhydride acyl chloride and hydroxyl groups is used to introduce an anhydride group into the molecular chain. Finally, an esterification reaction between anhydride and hydroxyl groups is used to introduce quaternary phosphonium salt and silver citrate structures into the molecular chain, resulting in a novel, highly efficient bactericide. The novel, highly efficient bactericide prepared by this invention simultaneously contains quaternary ammonium salt, quaternary phosphonium salt, and metallic silver ions. The positively charged quaternary ammonium salt and quaternary phosphonium salt are adsorbed onto the negatively charged bacterial surface through electrostatic interactions, exerting antibacterial and bacteriostatic effects by altering membrane permeability. The silver ions in silver citrate can bind to the sulfhydryl and carboxyl groups of bacterial membrane proteins, disrupting membrane integrity and thus exerting antibacterial and bacteriostatic effects.
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