A collagen-hydrating soft, hydrophilic contact lens and method of making same

Abstract

The application provides a collagen moisturizing soft hydrophilic contact lens and a preparation method thereof, and belongs to the technical field of soft hydrophilic contact lenses. The contact lens is prepared from HEMA, DMAA and MA as main base materials, and four types of functional components, namely, polydeoxyribonucleotide (PDRN), PEG400, sodium hyaluronate and chitosan derivative, are compounded. An initiator of azobisdimethylvaleronitrile and benzoyl peroxide and a crosslinking agent of ethylene glycol dimethacrylate and pentaerythritol tetraacrylate are compounded. The contact lens is prepared through segmented constant temperature polymerization and sufficient post-treatment and refining. The application simulates the moisturizing mechanism of collagen by constructing a three-dimensional deep water locking network through natural moisturizing components, and long-acting water locking and soothing eye dryness. The application greatly improves the ocular surface biocompatibility of the lens by relying on the biological activity components and low-toxicity mild formula, reduces the residual monomer toxicity, and has no eye irritation.

Description

Technical Field

[0001] This invention relates to the field of soft hydrophilic contact lens technology, and more particularly to a collagen moisturizing soft hydrophilic contact lens and its preparation method. Background Technology

[0002] Soft hydrophilic contact lenses are widely used in myopia correction and cosmetic procedures due to their comfort and good fit. With the increasing number of users and the longer wearing time, the moisturizing performance, biocompatibility, and safety of contact lenses have become core concerns for users.

[0003] Most existing soft hydrophilic contact lenses use HEMA (hydroxyethyl methacrylate) as the main material, achieving basic moisturization by adding simple humectants. However, this method suffers from short-lasting and insufficient moisturizing effect, leading to rapid evaporation of tears over time with prolonged wear, causing dryness, foreign body sensation, and even damage to corneal epithelial cells. Furthermore, some contact lens materials contain chemical components with poor biocompatibility, and residual monomers can easily produce toxic irritants, potentially causing eye inflammation with prolonged contact. In addition, traditional contact lenses struggle to balance moisturizing performance with lens mechanical properties, often resulting in lens deformation and decreased oxygen permeability after improved moisturizing.

[0004] Currently, there is a lack of soft hydrophilic contact lenses on the market that can achieve deep moisturizing at the collagen level, while also possessing excellent biocompatibility, low toxicity, and mechanical properties and oxygen permeability that meet wearing requirements. Therefore, developing a soft hydrophilic contact lens based on natural moisturizing mechanisms, with safe ingredients and balanced performance has become an urgent technical problem to be solved in this field. Summary of the Invention

[0005] The purpose of this invention is to provide a collagen-moisturizing soft hydrophilic contact lens and its preparation method, so as to solve the above-mentioned technical problems.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a collagen-based moisturizing soft hydrophilic contact lens, prepared from raw materials comprising the following mass percentages: Hydroxyethyl methacrylate 55-70%, N,N-dimethylacrylamide 8-15%, methyl acrylate 3-8%, polydeoxyribonucleotide 0.5-2%, polyethylene glycol 400 2-6%, sodium hyaluronate 1-4%, chitosan derivative 0.8-3%, initiator 0.3-1.2%, crosslinking agent 1.5-5%.

[0007] Furthermore, the initiator is a complex of azodimethylvalerate and benzoyl peroxide, with a weight ratio of azodimethylvalerate to benzoyl peroxide of 1:1 to 3:1.

[0008] Furthermore, the crosslinking agent is a compound of ethylene glycol dimethacrylate and pentaerythritol tetraacrylate, with a weight ratio of ethylene glycol dimethacrylate to pentaerythritol tetraacrylate of 2:1 to 4:1.

[0009] Furthermore, the chitosan derivative is carboxymethyl chitosan or hydroxypropyl chitosan.

[0010] This invention also provides a method for preparing a collagen-moisturizing soft hydrophilic contact lens, comprising the following steps: 1) Under sterile and light-protected conditions, weigh hydroxyethyl methacrylate, N,N-dimethylacrylamide, methyl acrylate and polyethylene glycol 400 according to their mass percentages and mix them evenly to obtain a premix. 2) Add sodium hyaluronate, chitosan derivative and polydeoxyribonucleotide to the premix in sequence and mix well to obtain a functional mixture; 3) Dilute the initiator and crosslinking agent with hydroxyethyl methacrylate respectively, and then add them sequentially to the functional mixture to carry out the polymerization reaction and obtain the polymerization reaction solution; 4) The polymerization reaction solution is sequentially degassed and molded to obtain a contact mirror blank; 5) The contact lens blank is immersed in purified water multiple times, then cut, polished and sterilized, and cooled to obtain a collagen moisturizing soft hydrophilic contact lens.

[0011] Furthermore, in step 1), the mixing time is 15-25 minutes.

[0012] Furthermore, in step 2), the mixing speed is 100~200 r / min, the mixing temperature is 25~30℃, and the mixing time is 30~40 min.

[0013] Furthermore, in step 3), the polymerization temperature is 25~35℃ and the polymerization time is 20~30min.

[0014] Furthermore, in step 4), the vacuum degree of the degassing treatment is -0.08 to -0.1 MPa, and the degassing treatment time is 15 to 20 minutes; The molding process involves injecting the degassed reaction solution into a contact mirror mold, followed by segmented polymerization after mold closing: reacting at 65~70℃ for 1.5~2.5h, at 70~80℃ for 2~3h, and at 80~90℃ for 1~1.5h to obtain a contact mirror blank.

[0015] Furthermore, in step 5), the soaking is performed 3 to 4 times, with each soaking lasting 24 to 48 hours; the sterilization temperature is 120 to 125°C, and the sterilization time is 20 to 30 minutes.

[0016] The beneficial effects of this invention are: 1. This invention utilizes the triple moisturizing synergistic effect of sodium hyaluronate, PEG400, and chitosan derivatives to simulate the natural moisturizing mechanism of collagen. The lens has strong water-locking ability and long-lasting moisturizing effect, which can effectively relieve dry eyes and foreign body sensation caused by long-term wear, significantly improve wearing comfort, and solve the technical problem of insufficient moisturizing in existing contact lenses.

[0017] 2. This invention uses biocompatible components such as PDRN and chitosan derivatives, combined with HEMA-DMAA hydrophilic substrate, resulting in good compatibility between the lens and ocular surface tissue, which can reduce eye irritation and inflammatory reactions. At the same time, PDRN can promote corneal epithelial cell repair, making it suitable for long-term wear by people with sensitive eyes. Combining the advantages of the application of natural biomaterials in contact lenses in existing technologies, the biosafety of the lens is further improved.

[0018] 3. All components in this invention are made from low-toxicity raw materials. The monomer conversion rate is improved through a segmented polymerization process, and residual monomers are removed through thorough post-treatment. The residual monomer content of the lens is ≤0.01% after testing, with no obvious cytotoxicity, and there is no safety hazard for long-term wear. At the same time, the use of highly toxic components in traditional contact lenses is avoided, which meets the safety standards for ophthalmic materials.

[0019] 4. This invention adjusts lens hardness using MA and constructs a stable three-dimensional network using a compound cross-linking agent, resulting in lenses with excellent elasticity, toughness, and dimensional stability, making them less prone to deformation and breakage. Simultaneously, the synergistic effect of the moisturizing components and the substrate ensures excellent oxygen permeability, with an oxygen permeability coefficient (DK) ≥ 25 × 10⁻⁶. -11 (cm 2 The formula ( / s)(mL O2 / (mL·mmHg)) can meet the oxygen permeability requirements for long-term wear, avoid corneal hypoxia damage, and balance moisturizing properties with mechanical and oxygen permeability performance.

[0020] 5. This invention employs a segmented polymerization process with mild and easily controllable reaction conditions, effectively preventing component degradation and improving lens quality stability. The post-processing is simple, enabling large-scale industrial production and reducing production costs. At the same time, it draws on the mature experience of existing contact lens manufacturing processes to ensure product consistency and reliability. Detailed Implementation

[0021] This invention provides a collagen-based moisturizing soft hydrophilic contact lens, prepared from raw materials comprising the following mass percentages: Hydroxyethyl methacrylate 55-70%, N,N-dimethylacrylamide 8-15%, methyl acrylate 3-8%, polydeoxyribonucleotide 0.5-2%, polyethylene glycol 400 2-6%, sodium hyaluronate 1-4%, chitosan derivative 0.8-3%, initiator 0.3-1.2%, crosslinking agent 1.5-5%.

[0022] In this invention, the content of hydroxyethyl methacrylate, by mass percentage, is preferably 60-65%, more preferably 61-64%.

[0023] In this invention, the content of N,N-dimethylacrylamide is preferably 10-14% by mass percentage, and more preferably 11-13%.

[0024] In this invention, the content of methyl acrylate is preferably 4-7% by mass percentage, and more preferably 5-6%.

[0025] In this invention, the content of the polydeoxyribonucleotide is preferably 0.8-1.8% by mass, and more preferably 1-1.5%.

[0026] In this invention, the content of polyethylene glycol 400 is preferably 3-5% by mass percentage, and more preferably 3.5-4%.

[0027] In this invention, the content of sodium hyaluronate, by mass percentage, is preferably 2-3%, more preferably 2.5-3%.

[0028] In this invention, the content of the chitosan derivative is preferably 1 to 2.5% by mass percentage, and more preferably 1.5 to 2%.

[0029] In this invention, the content of the initiator is preferably 0.5-1.0% by mass percentage, more preferably 0.7-0.9%.

[0030] In this invention, the content of the crosslinking agent is preferably 2-4% by mass percentage, and more preferably 2.5-3.5%.

[0031] In this invention, the initiator is a complex of azodimethylvalerate and benzoyl peroxide, and the weight ratio of azodimethylvalerate to benzoyl peroxide is 1:1 to 3:1, preferably 1:1, 2:1, or 3:1.

[0032] In this invention, the crosslinking agent is a compound of ethylene glycol dimethacrylate and pentaerythritol tetraacrylate, and the weight ratio of ethylene glycol dimethacrylate to pentaerythritol tetraacrylate is 2:1 to 4:1, preferably 2:1, 3:1 or 4:1.

[0033] In this invention, the chitosan derivative is carboxymethyl chitosan or hydroxypropyl chitosan, preferably carboxymethyl chitosan, which has better water solubility and biocompatibility, and can synergistically enhance moisturizing performance with sodium hyaluronate, while also enhancing the biocompatibility between the lens and the ocular surface.

[0034] This invention achieves deep moisturizing at the collagen level, excellent biocompatibility, and low toxicity through the scientific ratio and synergistic effect of its components. The specific effects are as follows: Synergistic Moisturizing System: A triple moisturizing network is constructed using sodium hyaluronate, PEG400, and chitosan derivatives. Sodium hyaluronate has extremely strong water-locking ability and can mimic the moisturizing mechanism of collagen to form a breathable and water-locking film on the lens surface for deep moisturizing. PEG400, as a hydrophilic diluent, can enhance the hydrophilicity of the lens, promote tear adsorption and retention, and prolong the moisturizing effect. Chitosan derivatives can form hydrogen bonds with sodium hyaluronate to further enhance water-locking performance, while improving the lubrication of the lens surface, reducing the feeling of foreign objects when wearing it, and achieving a collagen-level moisturizing effect.

[0035] Improved biocompatibility: PDRN has good bioactivity, which can promote corneal epithelial cell repair and reduce eye irritation; chitosan derivatives, as natural biomaterial derivatives, have good compatibility with human tissues and can reduce frictional damage between the lens and the ocular surface; HEMA and DMAA are combined as a base material, which has excellent biocompatibility and can reduce the toxicity risk of residual monomers; all components are made from low-toxicity raw materials, and residual monomers are effectively removed through segmented polymerization and sufficient post-treatment, further reducing toxicity and ensuring long-term wear safety.

[0036] Mechanical balance and oxygen permeability: MA, as a hydrophobic monomer, can adjust the hardness and elasticity of the lens, avoiding the lens from becoming too soft and easily deformed due to the addition of high moisturizing components; EGDMA and pentaerythritol tetraacrylate are compounded as crosslinking agents to build a stable three-dimensional polymer network, improving the mechanical strength, toughness and dimensional stability of the lens; at the same time, the synergistic effect of PEG400 and sodium hyaluronate can maintain the breathability of the lens while ensuring deep moisturization, ensuring that the cornea receives sufficient oxygen and avoiding corneal hypoxia damage.

[0037] Initiation system optimization: ADVN and BPO are combined as initiators to achieve low-temperature segmented polymerization, avoiding component degradation caused by high-temperature polymerization, while improving polymerization conversion rate, reducing residual monomers and reducing toxicity; the synergistic effect of the combined initiators can make the polymerization reaction more uniform and improve the transparency and surface smoothness of the lens.

[0038] This invention also provides a method for preparing a collagen-moisturizing soft hydrophilic contact lens, comprising the following steps: 1) Under sterile and light-protected conditions, weigh hydroxyethyl methacrylate, N,N-dimethylacrylamide, methyl acrylate and polyethylene glycol 400 according to their mass percentages and mix them evenly to obtain a premix. 2) Add sodium hyaluronate, chitosan derivative and polydeoxyribonucleotide to the premix in sequence and mix well to obtain a functional mixture; 3) Dilute the initiator and crosslinking agent with hydroxyethyl methacrylate respectively, and then add them sequentially to the functional mixture to carry out the polymerization reaction and obtain the polymerization reaction solution; 4) The polymerization reaction solution is sequentially degassed and molded to obtain a contact mirror blank; 5) The contact lens blank is immersed in purified water multiple times, then cut, polished and sterilized, and cooled to obtain a collagen moisturizing soft hydrophilic contact lens.

[0039] In this invention, the mixing time in step 1) is 15-25 min, preferably 18-22 min, and more preferably 20 min.

[0040] In this invention, in step 2), the mixing speed is 100~200 r / min, preferably 120~150 r / min; the mixing temperature is 25~30℃, preferably 26℃; and the mixing time is 30~40 min, preferably 35 min.

[0041] In this invention, in step 3), the polymerization temperature is 25~35℃, preferably 28~32℃, and more preferably 35℃; the polymerization time is 20~30min, preferably 25min.

[0042] In this invention, in step 4), the vacuum degree of the degassing treatment is -0.08 to -0.1 MPa, preferably -0.05 MPa; the degassing treatment time is 15 to 20 minutes, preferably 18 minutes. The molding process involves injecting the degassed reaction solution into a contact mirror mold, followed by segmented polymerization after mold closing: reacting at 65-70℃ for 1.5-2.5 hours, at 70-80℃ for 2-3 hours, and at 80-90℃ for 1-1.5 hours to obtain a contact mirror blank; preferably, the segmented polymerization process involves reacting at 66-68℃ for 2 hours, at 74-78℃ for 2.5 hours, and at 82-90℃ for 1 hour.

[0043] In this invention, in step 5), the number of soaking times is 3 to 4, each soaking time is 24 to 48 hours, preferably 24 hours; the sterilization temperature is 120 to 125°C, preferably 121°C; and the sterilization time is 20 to 30 minutes, preferably 25 minutes.

[0044] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0045] Example 1

[0046] A collagen-based moisturizing soft hydrophilic contact lens, with the following mass fractions of each component: HEMA: 60%, DMAA: 12%, MA: 5%, PDRN: 1.0%, PEG400: 4%, Sodium hyaluronate: 2.5%, Chitosan derivative (carboxymethyl chitosan): 2.0%, Initiator (ADVN:BPO=2:1): 0.8%, Crosslinking agent (EGDMA:Pentaerythritol tetraacrylate=3:1): 2.7%.

[0047] Preparation method: 1) Under sterile and light-protected conditions, weigh the above-mentioned mass fractions of HEMA, DMAA, and MA, add them to the reaction vessel, and stir until homogeneous; add PEG400, stir for 20 minutes, and form a premix.

[0048] 2) Add sodium hyaluronate, carboxymethyl chitosan and PDRN to the premix in sequence. Stir at 150 r / min for 35 min at 28℃ until completely dissolved to obtain the functional mixture.

[0049] 3) Mix ADVN and BPO at a weight ratio of 2:1 and dilute with a small amount of HEMA; mix EGDMA and pentaerythritol tetraacrylate at a weight ratio of 3:1 and dilute with a small amount of HEMA; slowly add the functional mixtures separately and stir for 25 minutes to obtain the polymerization reaction solution.

[0050] 4) Place the polymerization reaction solution in a vacuum degassing machine and degas for 18 minutes at -0.09 MPa to remove air bubbles. Inject the reaction solution into the mold, close the mold, and place it in a constant temperature polymerization chamber. React at 65℃ for 2 hours, 75℃ for 2.5 hours, and 85℃ for 1.2 hours to obtain the contact mirror blank.

[0051] 5) Take out the blank and soak it in purified water for 36 hours, changing the purified water 3 times; cut and polish to obtain the semi-finished product; put the semi-finished product into a sterilization container containing 0.9% physiological saline, sterilize it with high pressure steam at 121℃ and 0.1MPa for 25 minutes, and obtain the finished product after cooling.

[0052] Example 2

[0053] A collagen-based moisturizing soft hydrophilic contact lens, with the following mass fractions of each component: HEMA: 65%, DMAA: 10%, MA: 4%, PDRN: 0.8%, PEG400: 3%, Sodium hyaluronate: 3%, Chitosan derivative (hydroxypropyl chitosan): 1.5%, Initiator (ADVN:BPO=3:1): 0.5%, Crosslinking agent (EGDMA:Pentaerythritol tetraacrylate=4:1): 2.2%.

[0054] The preparation method is basically the same as in Example 1, except that: the stirring temperature of the functional component is 25℃ and the stirring time is 40min; in step 4), the segmented polymerization reaction conditions are 68℃ for 2.5h, 72℃ for 3h, and 85℃ for 1.5h; the post-treatment soaking time is 48h, and the purified water is replaced 4 times; the sterilization time is 30min.

[0055] Example 3

[0056] A collagen-based moisturizing soft hydrophilic contact lens, with the following mass fractions of each component: HEMA: 55%, DMAA: 15%, MA: 8%, PDRN: 2.0%, PEG400: 6%, Sodium hyaluronate: 1%, Chitosan derivative (carboxymethyl chitosan): 0.8%, Initiator (ADVN:BPO=1:1): 1.2%, Crosslinking agent (EGDMA:Pentaerythritol tetraacrylate=2:1): 5%.

[0057] The preparation method is basically the same as in Example 1, except that: the stirring temperature of the functional component is 30℃ and the stirring time is 30min; the segmented polymerization reaction conditions in step 4) are 65℃ for 1.5h, 78℃ for 2h, and 86℃ for 1h; the post-treatment soaking time is 24h, and the purified water is replaced 3 times; the sterilization time is 20min.

[0058] The performance of the soft hydrophilic contact lenses prepared in Examples 1-3 was tested, and the test results are shown in Table 1 below: Table 1 Test Results

[0059] Comparative Example 1

[0060] A soft hydrophilic contact lens, which differs from Example 1 in that it does not contain sodium hyaluronate and chitosan derivatives, while the remaining components, weight percentages, and preparation methods are the same as in Example 1.

[0061] The comparative example lacks sodium hyaluronate and chitosan derivatives, thus failing to form a triple moisturizing network. Its moisturizing effect lasts only 5 hours, far less than the 12 hours of Example 1. Furthermore, the lens surface has poor lubrication, resulting in a noticeable foreign body sensation when worn. Biocompatibility testing showed slight eye irritation, and the residual monomer content was 0.018%, slightly higher than the ≤0.01% standard specified in this invention.

[0062] Comparative Example 2

[0063] A soft hydrophilic contact lens, which differs from Example 1 in that only ADVN (azodimethylpentanonitrile) is used as the initiator, and BPO (benzoyl peroxide) is not added. The remaining components, weight percentages, and preparation methods are the same as in Example 1.

[0064] Because this comparative example uses a single initiator, the polymerization reaction is uneven, resulting in poor lens transparency, a residual monomer content as high as 0.032%, and a cytotoxicity level of 2, which does not meet safety standards. At the same time, the polymerization conversion rate is low, the mechanical strength of the lens is insufficient, and the elongation at break is only 320%, which is lower than the standard requirement of ≥350%, and it is easily deformed and damaged.

[0065] Comparative Example 3

[0066] A soft hydrophilic contact lens differs from Example 1 in that only EGDMA (ethylene glycol dimethacrylate) is used as the crosslinking agent, without the addition of pentaerythritol tetraacrylate. The remaining components, weight percentages, and preparation methods are the same as in Example 1.

[0067] This comparative example, due to the use of a single crosslinking agent, could not construct a stable three-dimensional polymer network, resulting in insufficient lens toughness, an elongation at break of 330%, and an oxygen permeability coefficient of only 23×10⁻⁶. - ¹¹, lower than the ≥25×10 specified in this invention - ¹¹Standard; at the same time, the moisturizing components cannot be stably fixed in the lens substrate, and the moisturizing effect is only 7 hours, which cannot achieve a deep moisturizing effect.

[0068] As can be seen from the above embodiments, the present invention provides a collagen-moisturizing soft hydrophilic contact lens and its preparation method. The contact lens products prepared in the above three comparative examples were subjected to the same performance tests. Combined with the test results of Examples 1-3, it can be seen that: the lack of core moisturizing components (sodium hyaluronate, chitosan derivatives) leads to a significant decrease in moisturizing performance and poorer biocompatibility; a single initiator reduces polymerization conversion rate, increases residual monomer content, enhances toxicity, and reduces mechanical properties; a single crosslinking agent destroys the three-dimensional network structure of the lens, resulting in substandard oxygen permeability and mechanical properties.

[0069] This invention achieves a synergistic improvement in moisturizing properties, biocompatibility, low toxicity, mechanical properties, and oxygen permeability through the scientific compounding of its components (triple moisturizing system, compound initiator, and compound cross-linking agent). This overcomes many drawbacks of existing single-component or single-system technologies, highlighting the technological innovation and superiority of this invention. This invention constructs a three-dimensional deep water-locking network through the synergistic construction of natural moisturizing components, mimicking the moisturizing mechanism of collagen, providing long-lasting hydration and soothing dry eyes. Relying on bioactive components and a low-toxicity, gentle formula, it significantly improves the biocompatibility of the lens surface, reduces residual monomer toxicity, and eliminates eye irritation. Simultaneously, the compound cross-linking system balances mechanical strength and oxygen permeability, resulting in stable lens dimensions, comfortable wear, and suitability for long-term daily wear. The process of this invention is gentle and controllable, with a high yield rate. The resulting hydrophilic contact lenses combine the advantages of long-lasting deep moisturizing, excellent biocompatibility, low cytotoxicity, and balanced mechanical and oxygen permeability, perfectly solving the technical defects of traditional soft contact lenses, such as insufficient moisturizing, strong irritation, and performance imbalance. It is suitable for all types of myopic individuals, especially those with sensitive eyes.

[0070] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A collagen-moisturizing soft hydrophilic contact lens, characterized in that, It is prepared from raw materials comprising the following mass percentages: Hydroxyethyl methacrylate 55-70%, N,N-dimethylacrylamide 8-15%, methyl acrylate 3-8%, polydeoxyribonucleotide 0.5-2%, polyethylene glycol 400 2-6%, sodium hyaluronate 1-4%, chitosan derivative 0.8-3%, initiator 0.3-1.2%, crosslinking agent 1.5-5%.

2. The collagen-moisturizing soft hydrophilic contact lens according to claim 1, characterized in that, The initiator is a complex of azodimethylvalerate and benzoyl peroxide, with a weight ratio of azodimethylvalerate to benzoyl peroxide of 1:1 to 3:

1.

3. The collagen-moisturizing soft hydrophilic contact lens according to claim 1 or 2, characterized in that, The crosslinking agent is a compound of ethylene glycol dimethacrylate and pentaerythritol tetraacrylate, with a weight ratio of ethylene glycol dimethacrylate to pentaerythritol tetraacrylate of 2:1 to 4:

1.

4. The collagen-moisturizing soft hydrophilic contact lens according to claim 3, characterized in that, The chitosan derivative is carboxymethyl chitosan or hydroxypropyl chitosan.

5. The method for preparing the collagen moisturizing soft hydrophilic contact lens according to any one of claims 1 to 4, characterized in that, Includes the following steps: 1) Under sterile and light-protected conditions, weigh hydroxyethyl methacrylate, N,N-dimethylacrylamide, methyl acrylate and polyethylene glycol 400 according to their mass percentages and mix them evenly to obtain a premix. 2) Add sodium hyaluronate, chitosan derivative and polydeoxyribonucleotide to the premix in sequence and mix well to obtain a functional mixture; 3) Dilute the initiator and crosslinking agent with hydroxyethyl methacrylate respectively, and then add them sequentially to the functional mixture to carry out the polymerization reaction and obtain the polymerization reaction solution; 4) The polymerization reaction solution is sequentially degassed and molded to obtain a contact mirror blank; 5) The contact lens blank is immersed in purified water multiple times, then cut, polished and sterilized, and cooled to obtain a collagen moisturizing soft hydrophilic contact lens.

6. The preparation method according to claim 5, characterized in that, In step 1), the mixing time is 15-25 minutes.

7. The preparation method according to claim 5 or 6, characterized in that, In step 2), the mixing speed is 100~200 r / min, the mixing temperature is 25~30℃, and the mixing time is 30~40 min.

8. The preparation method according to claim 7, characterized in that, In step 3), the polymerization temperature is 25~35℃ and the polymerization time is 20~30min.

9. The preparation method according to claim 8, characterized in that, In step 4), the vacuum degree of the degassing treatment is -0.08 to -0.1 MPa, and the degassing treatment time is 15 to 20 minutes. The molding process involves injecting the degassed reaction solution into a contact mirror mold, followed by segmented polymerization after mold closing: reacting at 65~70℃ for 1.5~2.5h, at 70~80℃ for 2~3h, and at 80~90℃ for 1~1.5h to obtain a contact mirror blank.

10. The preparation method according to claim 5 or 9, characterized in that, In step 5), the soaking is performed 3 to 4 times, with each soaking lasting 24 to 48 hours; the sterilization temperature is 120 to 125°C, and the sterilization time is 20 to 30 minutes.

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