PH adjusting device for telmisartan intermediate synthesis

Abstract

The PH adjusting device comprises a box body and a box cover, a drainage cylinder is fixedly arranged in the box body, openings are formed in the top and the bottom of the drainage cylinder, a main stirring rod is rotatably arranged in the drainage cylinder, a plurality of first blades are fixedly arranged on the main stirring rod in an inclined mode, and a plurality of second blades are fixedly arranged on the main stirring rod. A supporting ring is fixedly arranged between the inner wall of the box body and the outer wall of the drainage cylinder, a plurality of rotatable auxiliary stirring rods are installed on the supporting ring in the circumferential direction, and a plurality of second blades are fixedly arranged on the auxiliary stirring rods. The telmisartan intermediate synthesis mixed liquid in the box body flows into the drainage barrel from the bottom opening of the drainage barrel and flows out of the top opening of the drainage barrel, the flowing-out circulating liquid downwards impacts the second blade, the second blade rotates automatically, the liquid is locally stirred, and the mixing efficiency is further improved.

Description

Technical Field

[0001] The utility model relates to the field of telmisartan intermediates, in particular to a pH regulating device for synthesizing telmisartan intermediates. Background Art

[0002] Sartans are the second-most popular antihypertensive drug used clinically after ACEI inhibitors. Telmisartan, a specific angiotensin II receptor antagonist, is a sartan. In humans, administration of 80 mg of telmisartan almost completely inhibits the angiotensin II-induced blood pressure increase. This inhibitory effect persists for 24 hours and is still detectable after 48 hours. The antihypertensive effect becomes increasingly evident within three hours of the first dose of telmisartan. Maximum antihypertensive effect is achieved four weeks after the start of treatment and can be maintained with long-term treatment. Telmisartan is therefore an excellent antihypertensive drug. Telmisartan's structure belongs to the non-biphenyl tetrazole class. The key step in its synthesis is the nucleophilic substitution reaction between 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole and 4'-bromomethyl-biphenyl-2-carboxylate to obtain the product. Among them, 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole is the key intermediate I in the synthesis. A neutralization reaction is required during the synthesis of the telmisartan intermediate to adjust the pH value of the added mixed solution to an appropriate value. However, the existing pH adjustment device for the synthesis of the telmisartan intermediate cannot fully stir the mixed solution, resulting in low neutralization reaction efficiency, which urgently needs to be improved. Utility Model Content

[0003] The utility model aims to provide a pH regulating device for synthesizing a telmisartan intermediate, so as to solve the problem that the existing pH regulating device for synthesizing a telmisartan intermediate cannot fully stir the mixed solution.

[0004] In order to solve the above problems, the utility model provides a pH regulating device for the synthesis of telmisartan intermediates, comprising a box body and a box cover, a drainage tube is fixedly provided in the box body, the top and bottom of the drainage tube are both open, a main stirring rod is rotatably provided in the drainage tube, a plurality of first blades are obliquely fixed on the main stirring rod, a support ring is fixed between the inner wall of the box body and the outer wall of the drainage tube, a plurality of rotatable auxiliary stirring rods are circumferentially installed on the support ring, and a plurality of second blades are fixed on the auxiliary stirring rods.

[0005] The PH regulating device for synthesizing a telmisartan intermediate provided by the utility model also has the following technical features:

[0006] Furthermore, a motor is fixedly provided on the top of the box cover, and the output shaft of the motor is fixedly connected to the main stirring rod coaxially.

[0007] Furthermore, the axes of the main stirring rod and the auxiliary stirring rod are perpendicular to each other.

[0008] Furthermore, a drainage cone is fixedly provided on the bottom of the box body, the central axis of the drainage cone coincides with the central axis of the drainage tube, and the side wall of the drainage cone is an arc surface extending upward.

[0009] Furthermore, the distance between the outer wall of the drainage tube and the inner wall of the box body is 10-15 cm.

[0010] Furthermore, a liquid outlet pipe is provided on the side wall of the box body, and a switch valve is installed on the liquid outlet pipe.

[0011] The utility model has the following beneficial effects: the main stirring rod rotates, and the main stirring rod drives the first blade to rotate, so that the telmisartan intermediate synthesis mixed liquid in the box body flows into the drainage tube from the bottom opening of the drainage tube, and flows out from the opening at the top of the drainage tube, and the outflowing circulating liquid impacts the second blade downward, and the second blade rotates to locally stir the liquid, thereby further improving the efficiency of the neutralization reaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 The figure is a schematic diagram of the overall structure of the pH regulating device for synthesizing the telmisartan intermediate. DETAILED DESCRIPTION

[0013] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments. It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present invention can be combined with each other.

[0014] like Figure 1 In the embodiment of the pH regulating device for synthesizing a telmisartan intermediate of the present invention shown in the figure, the device comprises a housing 10 and a housing cover 11. A drainage tube 2 is fixedly provided in the housing 10. The top and bottom of the drainage tube 2 are both open. A main stirring rod 3 is rotatably provided in the drainage tube 2. A plurality of first blades 31 are fixedly provided on the main stirring rod 3 at an angle. A support ring 4 is fixedly provided between the inner wall of the housing 10 and the outer wall of the drainage tube 2. A plurality of rotatable auxiliary stirring rods 5 are circumferentially installed on the support ring 4. A plurality of second blades 51 are fixedly provided on the auxiliary stirring rod 5. Specifically, the main stirring rod 3 rotates, and the main stirring rod 3 drives the first blades 31 to rotate, so that the telmisartan intermediate synthesis mixture in the housing 10 flows into the drainage tube 2 from the bottom opening of the drainage tube 2 and flows out from the opening at the top of the drainage tube 2. The outflowing circulating liquid impacts the second blades 51 downward, and the second blades 51 rotate to locally stir the liquid, further improving the efficiency of the neutralization reaction.

[0015] In one embodiment of the present application, a motor 110 is fixedly provided on the top of the box cover 11 , and an output shaft of the motor 110 is fixedly connected to the main stirring rod 3 coaxially.

[0016] In one embodiment of the present application, the axes of the main stirring rod 3 and the auxiliary stirring rod 5 are perpendicular to each other.

[0017] In one embodiment of the present application, a drainage cone 6 is fixedly provided at the bottom of the box body 10, the central axis of the drainage cone 6 coincides with the central axis of the drainage tube 2, and the side wall of the drainage cone 6 is an upwardly extending arc surface. Specifically, such a design facilitates the liquid to enter the drainage tube 2 more smoothly from the bottom of the drainage tube 2 and circulate upward.

[0018] In one embodiment of the present application, the distance between the outer wall of the drainage tube 2 and the inner wall of the box body 10 is 10-15 cm.

[0019] In one embodiment of the present application, a liquid outlet pipe 7 is provided on the side wall of the box body 10 , and a switch valve 71 is installed on the liquid outlet pipe 7 .

[0020] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A PH regulating device for synthesizing a telmisartan intermediate, characterized in that: It includes a box body and a box cover, a drainage tube is fixedly provided in the box body, the top and bottom of the drainage tube are both open, a main stirring rod is rotatably provided in the drainage tube, a plurality of first blades are fixedly provided on the main stirring rod at an angle, a support ring is fixed between the inner wall of the box body and the outer wall of the drainage tube, a plurality of rotatable auxiliary stirring rods are circumferentially installed on the support ring, and a plurality of second blades are fixed on the auxiliary stirring rods.

2. A PH regulating device for synthesizing Telmisartan intermediate according to claim 1, characterized in that: A motor is fixedly provided on the top of the box cover, and an output shaft of the motor is fixedly connected to the main stirring rod coaxially.

3. A PH regulating device for synthesizing Telmisartan intermediate according to claim 2, characterized in that: The axes of the main stirring rod and the auxiliary stirring rod are perpendicular to each other.

4. A PH regulating device for synthesizing Telmisartan intermediate according to claim 1, characterized in that: A drainage cone is fixedly provided on the bottom of the box body, the central axis of the drainage cone coincides with the central axis of the drainage tube, and the side wall of the drainage cone is an upwardly extending arc surface.

5. A PH regulating device for synthesizing Telmisartan intermediate according to claim 1, characterized in that: The distance between the outer wall of the drainage tube and the inner wall of the box body is 10-15 cm.

6. A PH regulating device for synthesizing Telmisartan intermediate according to claim 1, characterized in that: A liquid outlet pipe is provided on the side wall of the box body, and a switch valve is installed on the liquid outlet pipe.

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