Chromatographic filler solvent recovery device

Abstract

The utility model relates to a chromatographic filler solvent recovery device, which comprises a hot water circulating unit, a double-cone rotary vacuum drier, a filter pipeline, a buffer tank, a condenser, a collecting tank, a vacuum filter port and a reagent recovery port, the hot water circulating unit is connected with the double-cone rotary vacuum drier, and the double-cone rotary vacuum drier is provided with the vacuum filter port; the vacuum filter port is connected with the buffer tank through a filter pipeline, the buffer tank is connected with the condenser, and the collecting tank is arranged at the bottom of the condenser and connected with the reagent recovery port. Wherein a first filter screen and a second filter screen are arranged at the front end of the filter pipeline, and an electrostatic generator is arranged at the top of the tail end of the filter pipeline. Compared with the prior art, silica gel particles are effectively filtered out from organic solvent gas by adding the double filter screens and the electrostatic generator.

Description

Technical Field

[0001] The utility model relates to the technical field of drug production recovery, in particular to a chromatography filler solvent recovery device. Background Art

[0002] Originally, the silica gel used as filler in chromatography columns needed to be directly bagged and treated as hazardous waste. However, the current treatment process presents several problems: the presence of large amounts of organic solvents in the silica gel results in significant reagent loss; and the presence of large amounts of organic solvents in the silica gel poses safety hazards during transportation and handling. Therefore, to avoid waste and address safety hazards, the best solution is to separate the organic solvent from the silica gel in the waste and then recycle the organic solvent. Currently, no single device can achieve this. This is because the silica gel particles used in the reagents used in chromatography fillers are relatively fine in diameter. During double-cone vacuuming, these small silica gel particles are too light to be easily extracted by the vacuum, causing failures in the terminal treatment equipment. Therefore, the first reaction is to add a filter, but the filter's pore size creates new problems: if the filter's pore size is too coarse, it cannot filter small particles; if the filter's pore size is too fine, it can easily become clogged and prevent the extraction of reagents.

[0003] To address the above issues, we have made a series of improvements. Utility Model Content

[0004] The purpose of the utility model is to provide a chromatography filler solvent recovery device to overcome the above-mentioned shortcomings and deficiencies in the prior art.

[0005] A chromatography filler solvent recovery device comprises: a hot water circulation unit, a double-cone rotary vacuum dryer, a filtration pipeline, a buffer tank, a condenser, a collection tank, a vacuum filter port, and a reagent recovery port. The hot water circulation unit is connected to the double-cone rotary vacuum dryer. The double-cone rotary vacuum dryer is provided with a vacuum filter port, which is connected to the buffer tank via a filtration pipeline. The buffer tank is connected to the condenser. A collection tank is provided at the bottom of the condenser, which is connected to the reagent recovery port.

[0006] The front end of the filter pipe is provided with a first filter screen and a second filter screen, and the top of the end of the filter pipe is provided with an electrostatic generator. The pore size of the first filter screen is 10 μm, and the pore size of the second filter screen is 3 μm.

[0007] Beneficial effects of the utility model:

[0008] Compared with the traditional technology, the utility model effectively filters out silica gel particles from the gas of the organic solvent by adding a double filter screen and an electrostatic generator. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 It is a structural diagram of the present utility model.

[0010] Reference numerals:

[0011] Hot water circulation unit 100 , double-cone rotary vacuum dryer 200 , filter pipe 300 , first filter screen 310 , second filter screen 320 and electrostatic generator 330 .

[0012] Buffer tank 400 , condenser 500 , collection tank 600 , vacuum filter port 700 and reagent recovery port 800 . DETAILED DESCRIPTION

[0013] The present invention will be further described below in conjunction with specific embodiments. It should be understood that the following embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0014] Example 1

[0015] Figure 1 It is a structural diagram of the present utility model.

[0016] like Figure 1 As shown, a chromatography filler solvent recovery device includes: a hot water circulation unit 100, a double-cone rotary vacuum dryer 200, a filtering pipe 300, a buffer tank 400, a condenser 500, a collection tank 600, a vacuum filter port 700 and a reagent recovery port 800. The hot water circulation unit 100 is connected to the double-cone rotary vacuum dryer 200. The double-cone rotary vacuum dryer 200 is provided with a vacuum filter port 700. The vacuum filter port 700 is connected to the buffer tank 400 through the filtering pipe 300. The buffer tank 400 is connected to the condenser 500. A collection tank 600 is provided at the bottom of the condenser 500, and the collection tank 600 is connected to the reagent recovery port 800.

[0017] The front end of the filter pipe 300 is provided with a first filter 310 and a second filter 320, and the top of the end of the filter pipe 300 is provided with an electrostatic generator 330. The pore size of the first filter 310 is 10μm, and the pore size of the second filter 320 is 3μm.

[0018] The operating principle of the present invention is to form a hot water circulation system through the hot water circulation unit 100 and the double-cone rotary vacuum dryer 200. The hot water will be present in the outer jacket of the double-cone rotary vacuum dryer 200, thereby heating the waste liquid inside the double-cone rotary vacuum dryer 200. The waste liquid will enter from the top of the double-cone rotary vacuum dryer 200 and then be heated, turning the organic solvent into a gaseous state. The silica gel particles that cannot be gasified will be reduced to a solid form and precipitated in the double-cone rotary vacuum dryer 200, and then discharged through the discharge port at the bottom. The gaseous organic solvent needs to be evacuated through the vacuum filter port 700. The gas will enter the condenser 500 through the filter pipe 300 and the buffer tank 400. After condensation, the gaseous organic solvent will return to a liquid state and then be recovered through the reagent recovery port 800.

[0019] The innovation of this utility model lies in addressing the issues raised in the background art. By adding a first filter 310, a second filter 320, and an electrostatic generator 330 to the filtration conduit 300, we address the issue of light silica gel particles mixed in the gas entering the terminal condenser and causing damage to the equipment. First, installing filters is necessary, which is the most direct and effective solution. However, a single filter has its drawbacks: being too coarse will not filter out small silica gel particles, while being too fine will affect vacuum efficiency. Therefore, we designed a dual-stage filtration system: a first filter 310 and a second filter 320, each with different pore sizes. This multi-stage filtration system progressively reduces the amount of particulate matter, ensuring smooth passage of reagents while preventing clogging of overly fine filters in the first few stages. However, if the pore size is balanced between coarse and fine, particles can easily become stuck in the filters, requiring frequent filter changes. Therefore, layering is more effective than selecting a single filter with the appropriate pore size. Our first filter 310 and second filter 320 use pore sizes of 10μm and 3μm respectively, the purpose of which is to ensure the efficiency of vacuuming. However, such treatment will still miss some tiny silica gel particles. Therefore, we set up an electrostatic generator 330 at the end of the pipeline, which adsorbs some tiny silica gel particles. Due to its limited adsorption capacity, the electrostatic generator 330 is difficult to adsorb large particles. Therefore, the first filter 310 and the second filter 320 need to cooperate to filter out as many large particles as possible. This design not only ensures the filtration of silica gel, but also does not affect the efficiency of vacuuming.

[0020] Compared with the traditional technology, the utility model effectively filters out silica gel particles from the gas of the organic solvent by adding a double filter screen and an electrostatic generator.

[0021] The above describes the specific implementation of the present invention, but the present invention is not limited thereto. As long as it does not deviate from the purpose of the present invention, the present invention can also have various changes.

Claims

1. A chromatography filler solvent recovery device, characterized in that, include: A hot water circulation unit (100), a double-cone rotary vacuum dryer (200), a filtering pipe (300), a buffer tank (400), a condenser (500), a collecting tank (600), a vacuum filter port (700) and a reagent recovery port (800), wherein the hot water circulation unit (100) is connected to the double-cone rotary vacuum dryer (200), the double-cone rotary vacuum dryer (200) is provided with a vacuum filter port (700), the vacuum filter port (700) is connected to the buffer tank (400) through the filtering pipe (300), the buffer tank (400) is connected to the condenser (500), a collecting tank (600) is provided at the bottom of the condenser (500), and the collecting tank (600) is connected to the reagent recovery port (800); The front end of the filter pipe (300) is provided with a first filter screen (310) and a second filter screen (320), and the top of the end of the filter pipe (300) is provided with an electrostatic generator (330), the pore size of the first filter screen (310) is 10 μm, and the pore size of the second filter screen (320) is 3 μm.

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