Blood irradiation container based on linear accelerator

Abstract

The utility model provides a blood irradiation container based on a linear accelerator. The blood irradiation container comprises a base, a box body, a blood bag bracket, a two-dimensional ionization chamber matrix and finger-shaped ionization chambers, the box body is fixed on the base, the front side of the base is provided with a slot, and a two-dimensional ionization chamber matrix is inserted into the slot; a horizontally arranged transparent tube is arranged in the center of the box body, an insertion hole communicated with the transparent tube is formed in the front side of the box body, and the finger-shaped ionization chamber is inserted into the transparent tube from the insertion hole; the box body is also provided with a temperature monitoring system; a blood bag bracket is arranged in the box body and comprises a plurality of trays and supporting columns, wherein the trays are sequentially arranged from top to bottom, and the supporting columns are used for separating the adjacent trays. The container can solve the problems of uneven blood irradiation dose distribution, inaccurate temperature control, low irradiation efficiency and incapability of real-time monitoring in the prior art, thereby improving the blood irradiation effect and safety.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical technology field especially, it is a kind of blood irradiation container based on linear accelerator. BACKGROUND

[0002] Transfusion-associated graft versus host disease (TA-GVHD) is a rare but extremely serious adverse transfusion reaction, there is no effective treatment, mortality is as high as 90% or more. At present, internationally recognized irradiated blood is an effective means to prevent the complication. Traditional gamma-ray blood irradiation instrument mainly utilizes cesium-137 ( 137 Cs) radiation source to irradiate, but because of the complex approval of radiation source, supervision difficulty and high recovery cost, limit its wide application. In recent years, X-ray blood irradiation instrument gradually popular because of its easy approval and lower protection requirement, but its lower energy leads to insufficient penetration, it is difficult to realize the uniform distribution of radiation dose.

[0003] Linear accelerator is mainly used for the radiotherapy of tumor patients, at present, more than three thousand sets have been available in the whole country, can provide high-energy X-ray, is the best alternative of gamma-ray source. General blood irradiation process is to place 5cm thick solid water on accelerator treatment bed, blood bag is placed on it, and 1-2cm thick tissue compensation film is covered above blood bag, then vertical irradiation or front-back cross irradiation is carried out. However, air gap is prone to appear between compensation film and blood bag, and charged particle balance cannot be achieved around blood bag, dose unevenness is easily caused.

[0004] Therefore, the existing blood irradiation technology mainly has the following problems:

[0005] 1, dose distribution unevenness problem

[0006] Chinese patent with application publication number CN 220046653 U proposes the device to solve the air gap problem between compensation film and blood bag, but does not solve the charged particle balance problem around blood bag, and the efficiency is low, only 1-2 bags of blood can be handled each time.

[0007] 2, temperature control problem

[0008] The suitable storage temperature of whole blood and red blood cell component blood is 2℃-6℃, and platelet and apheresis granulocyte is 20℃-24℃. Existing irradiation method cannot accurately control blood temperature during operation, and temperature is crucial to the preservation and safety of blood components.

[0009] 3, dose real-time monitoring problem

[0010] The minimum dose of blood irradiation is 25Gy in "Blood Station Technical Operation Rules", and the dose of any part should not exceed 50Gy, but the current irradiation device cannot monitor absorbed dose in real time. The utility model discloses a blood irradiation container based on linear accelerator, which can solve the problems of uneven blood irradiation dose distribution, inaccurate temperature control, low irradiation efficiency and real-time monitoring in the prior art, thereby improving the effect and safety of blood irradiation.

[0011] Therefore, the utility model aims at providing a blood irradiation container based on linear accelerator, which can solve the problems of uneven blood irradiation dose distribution, inaccurate temperature control, low irradiation efficiency and real-time monitoring in the prior art, thereby improving the effect and safety of blood irradiation.

[0012] To achieve the above object, the technical scheme of the utility model is as follows:

[0013] A blood irradiation container based on linear accelerator, comprising a base, a box body, a blood bag bracket, a two-dimensional ionization chamber matrix and a finger-shaped ionization chamber.

[0014] The box body is fixed on the base, the front side of the base is provided with a slot, the two-dimensional ionization chamber matrix is inserted in the slot, and the two-dimensional ionization chamber matrix is located directly below the box body. The two-dimensional ionization chamber matrix can measure the surface dose distribution of the irradiation area in real time.

[0015] The central part of the box body is provided with a transparent tube arranged horizontally, the transparent tube extends along the front-rear direction of the box body, the front side of the box body is provided with a jack communicating with the transparent tube, and the finger-shaped ionization chamber is inserted into the transparent tube from the jack. The finger-shaped ionization chamber can monitor the radiation dose around the blood bag in real time. The box body is also provided with a temperature monitoring system.

[0016] The inside of the box body is provided with the blood bag bracket, which comprises a plurality of trays arranged from top to bottom and a plurality of support columns for separating adjacent trays.

[0017] Further, the temperature monitoring system comprises a temperature sensor, a connecting line and a control panel. The temperature sensor is located at the bottom of the box body, the control panel is arranged on the outer wall of the box body, and the temperature sensor is connected with the control panel through the connecting line. The temperature sensor monitors the water temperature in real time, and the control panel displays the current temperature and sends an alarm signal when the temperature exceeds the limit.

[0018] Further, the support column is fixed on the lower surface of the tray, and the upper surface of the tray is provided with a groove for inserting the support column. The free combination and disassembly of the plurality of trays are realized in the form of insertion.

[0019] Further, the lower end of the support column is also provided with a cylindrical plug which is inserted into the groove.

[0020] Further, the bottom of the box body is provided with a fixing groove for inserting the support column.

[0021] Further, the lower part of the base is provided with an adjustable supporting leg for adjusting the level of the base to ensure that the container remains horizontal during operation.

[0022] Further, the box body is made of transparent material.

[0023] Further, a water level scale is arranged on the outer side wall of the box.

[0024] Further, the edge of the tray is upwardly folded to form a flange.

[0025] Further, the base, the box and the blood bag holder are made of tissue equivalent material, such as organic glass or solid water material, which has a density close to water, ensuring the uniformity of the blood bag absorbed dose distribution.

[0026] Compared with the prior art, the blood irradiation container based on the linear accelerator has the following advantages:

[0027] 1. Uniformity of dose distribution: the box contains water, and through the water around the blood bag in the box, the problem of imbalance of charged particles around the blood bag is avoided, ensuring that each part of the blood receives uniform irradiation dose.

[0028] 2. Precise temperature control: the temperature monitoring system monitors the water temperature in the box in real time, ensuring the stability of the temperature during the blood irradiation process, and maintaining the activity and safety of the blood components.

[0029] 3. Real-time monitoring of dose: the two-dimensional ionization chamber matrix and the finger-shaped ionization chamber are used to monitor the dose distribution in real time, avoiding excessive irradiation or insufficient dose.

[0030] 4. High efficiency of irradiation: a plurality of trays are accommodated at a time, supporting simultaneous irradiation of multiple blood bags, significantly improving the operation efficiency.

[0031] 5. Flexibility and ease of use: the modular design makes the device easy to install, disassemble and maintain, and adapts to different usage requirements. BRIEF DESCRIPTION OF DRAWINGS

[0032] The accompanying drawings, which form a part of this description, are included to provide a further understanding of the application. The embodiments of the application and its

[0033] Figure 1 The structure schematic view of the blood irradiation container based on the linear accelerator according to the embodiment of the application;

[0034] Figure 2 The top view of the blood irradiation container based on the linear accelerator according to the embodiment of the application;

[0035] Figure 3 The A local enlarged view of the blood irradiation container based on the linear accelerator according to the embodiment of the application;

[0036] Figure 4 The B-B sectional view of the blood irradiation container based on the linear accelerator according to the embodiment of the application;

[0037] Figure 5 A structure schematic view of the blood bag bracket according to the embodiment of the present application;

[0038] Figure 6 A perspective view of the blood irradiation container based on the linear accelerator according to the embodiment of the present application.

[0039] Explanation of reference signs:

[0040] 1, base; 11, slot; 12, adjustable support foot; 2, box body; 21, jack; 22, temperature monitoring system; 221, temperature sensor; 222, connecting line; 223, control panel; 23, water level scale; 24, transparent tube; 25, fixing groove; 3, blood bag bracket; 31, tray; 32, support column; 33, plug; 34, groove; 35, flange; 4, two-dimensional ionization chamber matrix; 5, finger-shaped ionization chamber. DETAILED DESCRIPTION

[0041] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0042] In the description of the present application, it should be understood that the orientation or position relationship indicated by the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second" and the like are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features limited by "first", "second" and the like can explicitly or implicitly include one or more of the features. In the description of the present application, unless otherwise specified, the meaning of "a plurality of" is two or more.

[0043] In the description of the present application, it should be noted that, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the communication between two elements inside. For ordinary skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0044] The utility model discloses below will refer to the drawing and combine the embodiment to explain in detail.

[0045] As Figures 1-5 Illustrated, a kind of blood irradiation container based on linear accelerator, including base 1, box 2, blood bag bracket 3, two-dimensional ionization chamber matrix 4 and finger-shaped ionization chamber 5;

[0046] Box 2 is fixed on base 1, and the front side of base 1 is provided with slot 11, two-dimensional ionization chamber matrix 4 is inserted in slot 11, and two-dimensional ionization chamber matrix 4 is located just below box 2, and two-dimensional ionization chamber matrix 4 can measure the surface dose distribution of irradiation area in real time.

[0047] The central part of box 2 is provided with transparent tube 24 arranged horizontally, and transparent tube 24 extends along the front-back direction of box 2, and the front side of box 2 is provided with insertion hole 21 in communication with transparent tube 24, and finger-shaped ionization chamber 5 is inserted into transparent tube 24 from insertion hole 21, and finger-shaped ionization chamber 5 can monitor the radiation dose around blood bag in real time, and the shape in transparent tube matches finger-shaped ionization chamber, as Figure 4 Illustrated, and temperature monitoring system 22 is further provided on box 2, and temperature monitoring system 22 includes temperature sensor 221, connecting line 222 and control panel 223, temperature sensor 221 is located at the bottom of box 2, control panel 223 is arranged on the outer wall of box 2, and temperature sensor 221 is connected with control panel 223 through connecting line 222.Temperature sensor 221 monitors water temperature in real time, and control panel 223 displays current temperature and sends alarm signal when temperature is out of limit.

[0048] The inside of box 2 is provided with blood bag bracket 3, and blood bag bracket 3 includes a plurality of trays 31 arranged in sequence from top to bottom and support columns 32 for separating adjacent trays 31.

[0049] Illustratively, support column 32 is fixed on the lower surface of tray 31, and the upper surface of tray 31 is provided with recess 34 for inserting support column 32.The free combination and disassembly of multiple trays 31 are realized in the form of insertion.

[0050] Specifically, the lower end of support column 32 is further provided with cylindrical plug 33, and plug 33 is inserted into recess 34.

[0051] Illustratively, the bottom of box 2 is provided with fixed groove 25 for inserting support column 32.The stability of blood bag bracket placement can be improved.

[0052] Illustratively, the lower part of base 1 is provided with adjustable supporting leg 12 for adjusting the level of base 1, to ensure that the container remains horizontal during operation.

[0053] Illustratively, box 2 is made of transparent material.

[0054] Exemplarily, a water level scale 23 is arranged on the outer side wall of the box 2 to facilitate observation of water level change.

[0055] Exemplarily, the edge of the tray 31 is folded upward to form a flange 35, which blocks the blood bag to prevent it from falling off.

[0056] Exemplarily, the base 1, the box 2 and the blood bag holder 3 are made of tissue equivalent material, such as organic glass or solid water material, which has a density close to water to ensure the uniformity of the absorbed dose distribution of the blood bag.

[0057] The method of using the container is as follows:

[0058] (I) Preparation

[0059] 1. Place the container on the treatment bed of the linear accelerator and adjust the support feet to ensure that the base is horizontal.

[0060] 2. Select the appropriate number of trays according to the number of blood bags, place the blood bags on the trays, and stack the trays in the box in turn.

[0061] 3. If the irradiation is whole blood or red blood cell component blood, add 4℃ pure water in the box, if the irradiation is platelets or single-donor granulocytes, add 22℃ pure water; if the number of irradiation is 1-4 bags, add water to the water level scale 13cm, if 5-8 bags, add water to 23cm, to ensure that all blood bags are completely immersed.

[0062] 4. Place the two-dimensional ionization chamber matrix in the slot, and insert the finger-shaped ionization chamber into the transparent tube from the insertion hole, and connect the power supply and control line, as shown in Figure 6 .

[0063] (II) Irradiation operation

[0064] 1. Start the two-dimensional ionization chamber matrix and the finger-shaped ionization chamber.

[0065] 2. Start the temperature monitoring system to monitor the water temperature in the box in real time. If the temperature deviates from the set range (2-6℃ or 20-24℃), the control panel will issue an alarm signal to prompt adjustment of the water temperature.

[0066] 3. Turn on the linear accelerator and select the appropriate radiation energy, such as Figure 6 arrow direction, and select the appropriate machine number (MU) according to the water depth. During the irradiation process, the irradiation dose is monitored in real time by the finger-shaped ionization chamber, and the surface dose distribution is monitored by the two-dimensional ionization chamber matrix to ensure the accuracy and uniformity of the absorbed dose of the blood bag.

[0067] (III) Subsequent processing

[0068] 1. After the irradiation is completed, turn off the system and remove the blood bag holder.

[0069] 2. Clean the inside of the tank, drain the water, and sterilize the container base, tank and bracket, ready for use.

[0070] The above merely describes the preferred embodiments of the present application and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A blood irradiation container based on a linear accelerator, characterized in that: Includes a base, housing, blood bag holder, two-dimensional ionization chamber matrix, and finger-shaped ionization chamber; The enclosure is fixed to the base, and the front side of the base is provided with a slot in which a two-dimensional ionization chamber matrix is ​​inserted, and the two-dimensional ionization chamber matrix is ​​located directly below the enclosure. A horizontally arranged transparent tube is located in the center of the enclosure, extending along the front-to-back direction of the enclosure. The front of the enclosure has an insertion hole that communicates with the transparent tube. The finger-shaped ionization chamber is inserted into the transparent tube through the insertion hole. A temperature monitoring system is also installed on the enclosure. The inside of the box is equipped with a blood bag holder, which includes several trays arranged from top to bottom and supports for separating adjacent trays.

2. The blood irradiation container based on a linear accelerator according to claim 1, characterized in that: The temperature monitoring system includes a temperature sensor, connecting cables, and a control panel. The temperature sensor is located at the bottom of the enclosure, and the control panel is mounted on the outer wall of the enclosure. The temperature sensor is connected to the control panel via the connecting cables.

3. The blood irradiation container based on a linear accelerator according to claim 1, characterized in that: The support is fixed to the lower surface of the tray, and the upper surface of the tray has a groove for inserting the support.

4. The blood irradiation container based on a linear accelerator according to claim 3, characterized in that: The lower end of the support column is also equipped with a cylindrical plug, which is inserted into a groove.

5. The blood irradiation container based on a linear accelerator according to claim 3, characterized in that: The bottom of the box is provided with a fixing groove for inserting the support column.

6. The blood irradiation container based on a linear accelerator according to claim 1, characterized in that: The base has adjustable support feet.

7. The blood irradiation container based on a linear accelerator according to claim 1, characterized in that: The box is made of transparent material.

8. The blood irradiation container based on a linear accelerator according to claim 1, characterized in that: The outer wall of the tank is also equipped with water level markings.

9. The blood irradiation container based on a linear accelerator according to claim 1, characterized in that: The edges of the tray are folded upwards to form a folded edge.

Images