Uniform shaking device for drug synthesis
By designing a drug synthesis and mixing device with a V-shaped clamping block, clamping block structure, and rubber fastening layer, the problem of slippage of test tubes during high-frequency vibration was solved, achieving uniformity and stability of drug mixing, and reducing manufacturing costs and operational difficulty.
Patent Information
- Application Number
- CN202520931782.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-13
- Publication Date
- 2026-04-14
- Estimated Expiration
- 2035-05-13
AI Technical Summary
Existing drug synthesis mixing devices, when subjected to high-frequency or variable-angle vibration, are prone to micro-slippage of test tubes due to rigid clamping structures, and insufficient friction affects the uniformity of mixing.
The design incorporates V-shaped clamps and clamp structures, combined with a rubber fastening layer and an arc-shaped clamping plate. Multi-size compatibility is achieved through purely mechanical adjustment. The serrated texture increases friction, forming a multi-directional self-locking mechanism to prevent test tube displacement deviation.
It significantly reduces manufacturing costs and maintenance difficulty, improves the uniformity and stability of drug mixing, and is suitable for the needs of small and medium-sized laboratories that frequently switch containers.
Smart Images
Figure CN224113806U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of drug synthesis technology, and more specifically, to a drug synthesis shaking device. Background Technology
[0002] Drugs generally refer to active ingredients prepared through chemical synthesis, bio-fermentation, or formulation processes. Their production process involves steps such as raw material dissolution, dispersion, encapsulation, and homogenization. For example, chemically synthesized drugs require thorough mixing of intermediates and excipients, while biological agents (such as protein vaccines) rely on gentle shaking to maintain structural stability.
[0003] Currently, most drug synthesis mixing devices use rigid clamping structures to fix the test tubes. During vibration, inertia can easily cause slight slippage of the container, especially under high-frequency or variable-angle conditions. Insufficient friction between the clamping surface and the test tube may lead to displacement deviation. In view of this, we propose a drug synthesis mixing device. Utility Model Content
[0004] The purpose of this invention is to overcome the shortcomings of the existing technology, adapt to practical needs, and provide a drug synthesis shaking device to solve the technical problem that the existing rigid clamping structure is prone to micro-slippage of the test tube when vibrating at high frequency or variable angle, and the insufficient friction affects the uniformity of drug synthesis mixing.
[0005] To solve the above technical problems, the present invention provides the following technical solution: a drug synthesis shaking device, comprising a base, a vibration mechanism and a shaking mechanism, wherein the shaking mechanism is arranged on the vibration mechanism and the vibration mechanism is arranged inside the base, the shaking mechanism includes a support, a notch is provided at the front end of the support, a clamping unit is arranged in the notch, and an adjustment unit is arranged at one end of the support.
[0006] The clamping unit includes a clamping block A, which has a slot. A clamping block B is inserted into the slot. Both the clamping block B and the clamping block A have a V-shaped structure. The opening of the slot and one end of the clamping block B have a beveled structure.
[0007] Preferably, the vibration mechanism includes a plate, a drive motor, and pressure springs. A crank is connected to the middle of the lower surface of the plate, and the crank is connected to the output end of the drive motor. The four corners of the lower surface of the plate are connected to the base through pressure springs.
[0008] Preferably, the bracket is rotatably mounted in the bearing seat A via the shaft A, and the bearing seat A is fixed to the upper surface of the plate.
[0009] Preferably, an electric actuator is arranged at the rear end of the bracket, the output end of the electric actuator is connected to a moving plate, and the moving plate is arranged in the notch. A clamping block B is arranged in the middle of the moving plate, and both ends of the moving plate are connected to the inner wall of the notch through telescopic rods. The telescopic rod is composed of an inner rod inserted into a sleeve rod.
[0010] Preferably, the adjustment unit includes a hinge arranged at one end of the shaft A, a limit rod arranged on the hinge, one end of the limit rod being embedded in a slot, the slot being composed of two spring pieces and fixed to the side of the shaft seat A, and one end of the two spring pieces having a flared structure.
[0011] Preferably, both clamping block A and clamping block B have a fastening layer A on their inner wall surfaces. The fastening layer A is made of rubber material and has a serrated structure.
[0012] Preferably, a limit block is arranged at one end of the upper surface of both clamping block A and clamping block B, and a bearing B is arranged at the other end of the upper surface of both clamping block A and clamping block B. A shaft B is rotatably installed inside the bearing B, and a connecting rod is rotatably installed on the shaft B. A clamping plate is rotatably connected to one end of the connecting rod, and a fastening layer B is arranged on the side of the clamping plate. A torsion spring is arranged between the inside of one end of the connecting rod and the surface of the shaft B.
[0013] Compared with the prior art, the beneficial effects of this utility model are:
[0014] 1. This utility model, through the design of clamping blocks A and B, features a V-shaped structure that conforms to the curvature of the outer wall of the test tube. Combined with the guiding effect of the slot, it forms a progressive clamping force when the gap is reduced, avoiding container deformation caused by local stress concentration. Compared with traditional fully automatic shaking devices that rely on electric push rods or pneumatic clamps, this structure achieves multi-size compatibility through pure mechanical adjustment, reducing electronic components such as motors and sensors, significantly lowering manufacturing costs and maintenance difficulty. In addition, the pluggable design of clamping blocks B and A facilitates the replacement of test tubes of different specifications, making it particularly suitable for the needs of frequent container switching in small and medium-sized laboratories or teaching scenarios. It ensures clamping stability while taking into account economy and ease of operation.
[0015] 2. This utility model designs a fastening layer A structure with a serrated surface. When the test tube is clamped between clamping block A and clamping block B, the serrated texture increases the contact area with the outer wall of the test tube. During vibration, inertial force causes the serrated layer to produce a dynamic meshing effect with the test tube surface. During vertical vibration, the serrations are embedded into the outer wall of the test tube axially. During inclined or horizontal vibration, the lateral component force causes the serrations to produce lateral engagement, forming a multi-directional self-locking mechanism. This structure utilizes the elastic deformation characteristics of rubber material. When the vibration frequency increases, the serrated layer is subjected to periodic pressure deformation, which enhances the wedging effect and reduces displacement deviation caused by insufficient friction.
[0016] 3. This utility model, through the design of a clamping plate and a fastening layer B, features an arc-shaped clamping plate that fits snugly against the side of a cylindrical test tube. The internally installed fastening layer B also fits snugly against the side of the test tube, increasing friction and providing cushioning. This prevents the clamping plate from directly contacting the test tube, thus avoiding damage to its surface. When the distance between clamping blocks A and B is shortened, the clamping plate will adhere to the surface of the test tube and engage with the bottle neck ring, radially fixing the test tube. This, combined with clamping blocks A and B, provides axial fixation of the test tube, preventing it from radially slipping out of clamping blocks A and B during shaking. Attached Figure Description
[0017] Figure 1 This is a schematic diagram of the main appearance structure of this utility model;
[0018] Figure 2 This is a schematic diagram of the tilted structure of the main support of this utility model;
[0019] Figure 3 This is a schematic diagram of the vibration mechanism structure of this utility model;
[0020] Figure 4 This is a schematic diagram of the shaking mechanism of this utility model;
[0021] Figure 5 This is a schematic diagram of the combined clamping unit structure of this utility model;
[0022] Figure 6 This is a schematic diagram of the clamping unit separation structure of this utility model.
[0023] Explanation of the labels in the diagram:
[0024] 1. Base; 2. Vibration mechanism; 201. Flat plate; 202. Drive motor; 203. Compression spring; 204. Crank; 3. Shaking mechanism; 301. Bracket; 302. Notch; 303. Clamping unit; 3031. Clamping block A; 3032. Slot; 3033. Clamping block B; 3034. Fastening layer A; 3035. Limiting block; 3036. Shaft seat B; 3037. Shaft B; 3038. Linking rod; 3039. Clamping plate; 3040. Fastening layer B; 304. Adjustment unit; 3041. Hinge; 3042. Limiting rod; 3043. Slot; 305. Shaft A; 306. Shaft seat A; 307. Electric actuator; 308. Moving plate; 309. Telescopic rod; 4. Test tube. Detailed Implementation
[0025] like Figures 1 to 6As shown, the present invention relates to a drug synthesis shaking device, which includes a base 1, a vibration mechanism 2 and a shaking mechanism 3. The shaking mechanism 3 is arranged on the vibration mechanism 2, and the vibration mechanism 2 is arranged inside the base 1. The shaking mechanism 3 includes a support 301. A notch 302 is opened at the front end of the support 301. A clamping unit 303 is arranged in the notch 302. An adjustment unit 304 is arranged at one end of the support 301.
[0026] The clamping unit 303 includes a clamping block A3031, a slot 3032 is provided in the clamping block A3031, a clamping block B3033 is inserted into the slot 3032, both the clamping block B3033 and the clamping block A3031 are V-shaped, and the opening of the slot 3032 and one end of the clamping block B3033 are beveled. This invention utilizes the design of clamping blocks A3031 and B3033. Their V-shaped structure conforms to the curvature of the outer wall of the test tube 4, and with the guiding effect of the slot 3032, a progressive clamping force is formed when the gap is reduced, avoiding container deformation caused by local stress concentration. Compared with traditional fully automatic shaking devices that rely on electric push rods or pneumatic clamps, this structure achieves multi-size compatibility through pure mechanical adjustment, reducing electronic components such as motors and sensors, significantly reducing manufacturing costs and maintenance difficulty. In addition, the pluggable design of clamping blocks B3033 and A3031 facilitates the replacement of test tubes 4 of different specifications, which is especially suitable for the needs of frequent container switching in small and medium-sized laboratories or teaching scenarios. While ensuring clamping stability, it also takes into account economy and ease of operation. The bevel structure design makes it easier for clamping block B3033 to be inserted into clamping block A3031, which has the effect of guiding the movement and insertion.
[0027] In an embodiment of this invention, the vibration mechanism 2 includes a plate 201, a drive motor 202, and a pressure spring 203. A crank 204 is connected to the middle of the lower surface of the plate 201, and the crank 204 is connected to the output end of the drive motor 202. The four corners of the lower surface of the plate 201 are connected to the base 1 through the pressure spring 203. By designing the structure of the drive motor 202 and the crank 204, when the drive motor 202 rotates the crank 204 connected to the output end, the crank 204 will move the plate 201 back and forth within the base 1. This causes the bracket 301 mounted on the plate 201 and the test tube 4 placed inside the bracket 301 to shake, thereby shaking the medicine in the test tube 4.
[0028] In this embodiment of the invention, the bracket 301 is rotatably mounted in the bearing seat A306 via the shaft A305, and the bearing seat A306 is fixed to the upper surface of the plate 201. By designing the structure of the bearing seat A306 and the shaft A305, this invention allows the bracket 301 to rotate on the plate 201, thereby changing the state of the test tube 4 placed inside the bracket 301. This allows the test tube 4 to rotate to a vertical, tilted, or horizontal position, achieving the effect of changing the placement state of the test tube 4.
[0029] In an embodiment of this utility model, an electric actuator 307 is arranged at the rear end of the bracket 301. The output end of the electric actuator 307 is connected to a moving plate 308, which is arranged within the notch 302. A clamping block B3033 is arranged in the middle of the moving plate 308. Both ends of the moving plate 308 are connected to the inner wall of the notch 302 via telescopic rods 309, which are composed of an inner rod inserted into a sleeve rod. By designing the structure of the electric actuator 307 and the moving plate 308, this utility model allows the clamping block B3033 to actively shorten the distance between itself and the clamping block A3031, clamping and fixing the test tube 4 placed between the clamping blocks A3031 and B3033, thus providing a power output effect. The installation of the telescopic rod 309 supports and stabilizes both ends of the moving plate 308 when it moves within the notch 302, indirectly stabilizing the movement of the clamping block B3033 within the slot 3032.
[0030] In an embodiment of this utility model, the adjustment unit 304 includes a hinge 3041 arranged at one end of the shaft A305, a limiting rod 3042 arranged on the hinge 3041, one end of the limiting rod 3042 is embedded in the slot 3043, the slot 3043 is composed of two spring pieces and fixed to the side of the shaft seat A306, and one end of the two spring pieces is flared. This utility model, through the design of a limiting rod 3042 and a slot 3043 structure, allows for manual rotation of the limiting rod 3042 and insertion into the corresponding slot 3043 when the angle of the test tube 4 inside the bracket 301 needs to be adjusted. The spring is made of elastic metal material, and its flared end face provides a guiding function, enabling the limiting rod 3042 to be accurately engaged in three positioning positions: vertical 0°, tilted 45°, and horizontal 90°. For high-viscosity fluids (such as syrups or liposome emulsions), in the vertical state, gravity dominates the vertical convection of the fluid during vibration. At the tilted angle, the fluid is subjected to the combined action of centrifugal force and shear force to form a vortex. In the horizontal state, the laminar flow boundary is broken through the transverse centrifugal diffusion. This structure does not require a complex electronic control module and achieves angle switching through physical limiting, which simplifies the operation process and avoids the risk of corrosion of electronic components.
[0031] In embodiments of this invention, both clamping blocks A3031 and B3033 have a fastening layer A3034 on their inner walls. The fastening layer A3034 is made of rubber and has a serrated structure. By designing the fastening layer A3034 structure, which has a serrated surface, when the test tube 4 is clamped between clamping blocks A3031 and B3033, its serrated texture increases the contact area with the outer wall of the test tube 4. During vibration, inertial force causes a dynamic meshing effect between the serrated layer and the surface of the test tube 4. During vertical vibration, the serrations embed axially into the outer wall of the test tube 4; during inclined or horizontal vibration, the lateral component of the force causes the serrations to engage laterally, forming a multi-directional self-locking mechanism. This structure utilizes the elastic deformation characteristics of rubber material. As the vibration frequency increases, the serrated layer undergoes periodic pressure deformation, enhancing the wedging effect and reducing displacement deviation caused by insufficient friction.
[0032] In this embodiment of the present invention, a limit block 3035 is arranged at one end of the upper surface of clamping block A3031 and clamping block B3033, and a bearing seat B3036 is arranged at the other end of the upper surface of clamping block A3031 and clamping block B3033. A shaft B3037 is rotatably installed inside the bearing seat B3036, and a connecting rod 3038 is rotatably installed on the shaft B3037. One end of the connecting rod 3038 is rotatably connected to a clamping plate 3039. A fastening layer B3040 is arranged on the side of the clamping plate 3039, and a torsion spring is arranged between the inside of one end of the connecting rod 3038 and the surface of the shaft B3037. In this invention, when the limiting block 3035 is installed so that the clamping plate 3039 is no longer clamping the test tube 4, it is affected by the torsion spring and is bent down by the connecting rod 3038. It will then be stuck on its surface, preventing it from bending down completely, thus facilitating the clamping plate 3039 to clamp and fix the test tube 4 again. The torsion spring installed between the connecting rod 3038 and the shaft B3037 gives the connecting rod 3038 a rebound force. When the clamping blocks A3031 and B3033 shorten the distance between them and clamp and fix the test tube 4, the clamping plate 3039 will clamp onto the test tube 4 and apply elastic clamping pressure, thereby fixing the test tube 4. The fastening layer B3040 and the fastening layer A3034 are made of the same rubber material and are also serrated. Through the design of the clamping plate 303... 9. The fastening layer B3040 structure and the clamping plate 3039 adopt an arc-shaped structure design, which can fit against the side of the cylindrical test tube 4. The internally installed fastening layer B3040 also fits against the side of the test tube 4, increasing the friction between the clamping plate 3039 and the test tube 4 and providing cushioning. This prevents the clamping plate 3039 from directly contacting the test tube 4 and avoids direct contact damage to the surface of the test tube 4. When the distance between the clamping blocks A3031 and B3033 is shortened, the clamping plate 3039 will fit against the surface of the test tube 4 and lock with the bottle neck ring on the test tube 4, fixing the test tube 4 radially. Together with the clamping blocks A3031 and B3033, the test tube 4 is axially fixed, preventing the test tube 4 from radially detaching from the clamping blocks A3031 and B3033 when shaken.
[0033] Working Principle: This embodiment provides a drug synthesis and mixing device. During use, the operator first needs to connect an external power supply to the device and control its operation via a controller. The operator pours the drug to be synthesized into test tube 4, seals it, and then inserts test tube 4 into support 301, placing it between clamps A3031 and B3033. Once in this position, the operator controls the electric actuator 307, which pushes the output-connected moving plate 308. The moving plate 308 then moves multiple clamps B3033, thus causing clamps B3033 to... It will be inserted into slot 3032, shortening the distance between it and clamping block A3031, and clamping and fixing the test tube 4 placed between them. When clamping block A3031 cooperates with clamping block B3033 to axially clamp and fix the test tube 4, the clamping plate 3039 on its upper surface will radially clamp the test tube 4. After the test tube 4 is clamped and fixed, the operator starts drive motor 202. Drive motor 202 rotates crank 204 connected to the output end. Crank 204 moves plate 201 back and forth in base 1, so the test tube 4 placed on plate 201 will shake. When the test tube 4 After vertically placing the tube in clamps A3031 and B3033 and shaking it for a certain period of time, the operator needs to adjust the angle of test tube 4. For drug mixing and synthesis related to high-viscosity fluids, the specific operation involves the operator holding the limiting rod 3042 and pulling one end out of the vertical slot 3043. After pulling the limiting rod 3042 out of the slot 3043, the operator applies a rotational force to the limiting rod 3042. The rotation of the limiting rod 3042 will cause the support 301 to rotate along with it via shaft A305. When the support 301 tilts, the operator rotates the limiting rod 3042 and engages one end in the tilted position. The test tube 4 placed in the bracket 301 will be tilted in the slot 3043. At this time, the continued operation of the drive motor 202 will tilt and shake the test tube 4. After the medicine in the test tube 4 has been tilted and shaken for a certain period of time, the staff needs to make it lie flat and shake it. The staff will pull the limit rod 3042 out of the tilted slot 3043 and then rotate it to lock it into the flat slot 3043. In this way, the test tube 4 placed in the bracket 301 will be placed horizontally. At this time, the vibration will continue to shake it horizontally, thus completing the three-stage vibration and shaking operation of the medicine in the vertical, tilted and horizontal stages.
[0034] The embodiments disclosed herein are preferred embodiments, but are not limited thereto. Those skilled in the art can readily grasp the spirit of this utility model based on the above embodiments and make different extensions and variations. However, as long as they do not depart from the spirit of this utility model, they are all within the protection scope of this utility model.
Claims
1. A drug synthesis shaking apparatus, characterized in that: The device includes a base (1), a vibration mechanism (2), and a shaking mechanism (3). The shaking mechanism (3) is arranged on the vibration mechanism (2), and the vibration mechanism (2) is arranged inside the base (1). The shaking mechanism (3) includes a support (301). A notch (302) is provided at the front end of the support (301). A clamping unit (303) is arranged in the notch (302). An adjustment unit (304) is arranged at one end of the support (301). The clamping unit (303) includes a clamping block A (3031), a slot (3032) is provided in the clamping block A (3031), a clamping block B (3033) is inserted into the slot (3032), the clamping block B (3033) and the clamping block A (3031) are both V-shaped, and the opening of the slot (3032) and one end of the clamping block B (3033) are both beveled.
2. The drug synthesis shaking apparatus according to claim 1, characterized in that: The vibration mechanism (2) includes a plate (201), a drive motor (202) and a pressure spring (203). A crank (204) is connected to the middle of the lower surface of the plate (201). The crank (204) is connected to the output end of the drive motor (202). The four corners of the lower surface of the plate (201) are connected to the base (1) through the pressure spring (203).
3. The drug synthesis shaking apparatus according to claim 2, characterized in that: The bracket (301) is rotatably mounted in the bearing seat A (306) via the shaft A (305), and the bearing seat A (306) is fixed to the upper surface of the plate (201).
4. The drug synthesis shaking apparatus according to claim 3, characterized in that: An electric actuator (307) is arranged at the rear end of the bracket (301). The output end of the electric actuator (307) is connected to a moving plate (308), and the moving plate (308) is arranged in the notch (302). A clamping block B (3033) is arranged in the middle of the moving plate (308). Both ends of the moving plate (308) are connected to the inner wall of the notch (302) through telescopic rods (309), and the telescopic rods (309) are composed of an inner rod inserted into a sleeve rod.
5. The drug synthesis shaking apparatus according to claim 4, characterized in that: The adjustment unit (304) includes a hinge (3041) arranged at one end of the shaft A (305), a limit rod (3042) arranged on the hinge (3041), one end of the limit rod (3042) being embedded in a slot (3043), the slot (3043) being composed of two spring pieces and fixed to the side of the shaft seat A (306), one end of the two spring pieces being flared.
6. The drug synthesis shaking apparatus according to claim 5, characterized in that: The inner walls of clamping blocks A (3031) and B (3033) are provided with fastening layers A (3034), which are made of rubber material and have a serrated structure.
7. The drug synthesis shaking apparatus according to claim 6, characterized in that: Limiting blocks (3035) are arranged at one end of the upper surface of clamping block A (3031) and clamping block B (3033), and bearing seats B (3036) are arranged at the other end of the upper surface of clamping block A (3031) and clamping block B (3033). A shaft B (3037) is rotatably installed inside the bearing seat B (3036), and a connecting rod (3038) is rotatably installed on the shaft B (3037). A clamping plate (3039) is rotatably connected to one end of the connecting rod (3038), and a fastening layer B (3040) is arranged on the side of the clamping plate (3039). A torsion spring is arranged between the inside of one end of the connecting rod (3038) and the surface of the shaft B (3037).