Stem cell visual low-temperature storage bag and heat preservation box

Abstract

The utility model relates to a visible low-temperature preservation bag of stem cells and an incubator, the visible low-temperature preservation bag of stem cells comprises a bag body, a cold source cavity and an opening binding part, the bag body is a transparent bag body or a visible area is arranged on the side wall of the bag body, and a storage area for placing a stem cell collection bag is arranged in the bag body; the cold source cavity comprises a first cold source cavity arranged at the bottom of the inner side of the bag body and a second cold source cavity arranged on the inner side wall of the bag body and communicated with the first cold source cavity; the opening binding part is arranged at the top opening of the bag body. The stem cell heat preservation box comprises a box body, a plurality of subareas arranged in the box body and used for storing the stem cell visual low-temperature preservation bags and a cover, heat preservation materials are laid on the inner side walls and the bottoms of the subareas, a handle is arranged on the top of the cover, and a second label indication area is arranged on the outer wall of the box body. According to the utility model, the timely low-temperature preservation after the cells are collected can be met, and a new cold source can be replaced at any time by observing the temperature in the stem cell visible low-temperature preservation bag and the cell state, so that the cells are kept in a low-temperature environment, and the cell preservation time is prolonged.

Description

Technical Field

[0001] This utility model relates to medical equipment, and in particular to a visual cryopreservation bag and insulated box for stem cells. Background Technology

[0002] The effective preservation time of ex vivo hematopoietic stem cells (HSCs) depends on the preservation method, mainly divided into cryopreservation and non-cryopreservation. Cryopreservation includes deep-temperature freezing and liquid nitrogen storage, both of which require cryoprotectants, deep-temperature freezers or liquid nitrogen containers, and skilled professionals. Cryopreservation of blood cells has a long shelf life; the longest reported time for blood cells preserved in liquid nitrogen is 25 years, one of the longest reported cryopreservation times to date. Non-cryopreservation does not require cryoprotectants, only ordinary refrigerators or blood transport boxes, but the preservation time is very limited, usually measured in hours or days. This is mainly because cells preserved in this way still maintain vigorous metabolism, thus requiring the replenishment of consumed nutrients and oxygen. In addition, the accumulation of metabolic products in the living environment is also detrimental to their survival. Current research on non-cryopreservation of ex vivo HSCs mainly focuses on the temperature variable, and 4°C has been identified as the optimal preservation temperature. Hematopoietic stem cells are typically stored in a refrigerator or blood transport box for non-cryopreservation only after all stem cells have been collected. However, during the cell collection process, which usually takes 5-6 hours (and sometimes longer for some patients), the stem cells cannot be effectively preserved in a timely manner. Therefore, the stem cells are kept at room temperature, which has a certain impact on their survival.

[0003] Therefore, there is an urgent need for a device that can immediately and continuously preserve stem cells at low temperatures after they are ex vivo, thereby prolonging their survival. Utility Model Content

[0004] The purpose of this invention is to enable stem cells to be immediately and continuously preserved at low temperatures after being ex vivo, thereby providing a visible low-temperature preservation bag and insulated box for stem cells.

[0005] The objective of this utility model can be achieved through the following technical solutions:

[0006] One of the technical solutions of this utility model is to provide a visual cryopreservation bag for stem cells, including a bag body, a cold source cavity, and a drawstring opening.

[0007] The bag is a transparent bag or has a visible area on its side wall, and the bag has a storage area for placing the stem cell collection bag.

[0008] The cold source cavity includes a first cold source cavity located at the bottom of the inner side of the bag body and a second cold source cavity located on the inner side wall of the bag body and communicating with the first cold source cavity.

[0009] The drawstring opening is located at the top opening of the bag.

[0010] In some specific embodiments, the storage area is provided in several parts.

[0011] In some specific embodiments, at least one sidewall of the storage area coincides with the sidewall of the bag body, and the second cold source cavity is disposed on the inner sidewall of the bag body that coincides with the sidewall of the storage area.

[0012] In some specific embodiments, the visible area is located on the side wall of the bag body where the storage area and the bag body overlap.

[0013] In some specific embodiments, the outer wall of the bag is provided with a temperature indicator for displaying the temperature inside the bag.

[0014] In some specific embodiments, the outer wall of the bag is provided with a first label indication area.

[0015] In some specific embodiments, the drawstring portion includes a drawstring channel that is connected end to end and runs through the top opening edge of the bag body, and an elastic cord disposed in the drawstring channel. The drawstring channel has two holes, so that the two ends of the elastic cord extend out of the holes respectively.

[0016] In some specific embodiments, the outer wall of the bag body is also provided with a cold source replacement inlet communicating with the second cold source cavity, and the bottom of the bag body is also provided with a discharge outlet communicating with the first cold source cavity.

[0017] The second aspect of this utility model is to provide a stem cell incubator, comprising a box body, several compartments disposed within the box body for storing visible cryopreservation bags for stem cells, and a lid for sealing the box body. The inner walls and bottom of the compartments are lined with insulating material, and the lid has a handle on top.

[0018] In some specific embodiments, a second label indication area is provided on the outer wall of the box.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] (1) Whether it is a short-term or long-term cell collection, the stem cell visual low-temperature preservation bag provided by this utility model can meet the requirements of timely low-temperature preservation after cell collection. By observing the temperature and cell status inside the stem cell visual low-temperature preservation bag, a new cold source can be replaced at any time to keep the cells in a low-temperature environment and extend the cell preservation time.

[0021] (2) The stem cell incubator provided by this utility model can temporarily preserve a large number and many types of cells at low temperature in an orderly manner, and it is also convenient for staff to transfer them. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of a structure for a visual cryopreservation bag for stem cells.

[0023] Figure 2 This is a schematic diagram of another structure of a visual cryopreservation bag for stem cells.

[0024] Figure 3 This is a schematic diagram of the closed state of the binding area on a visual cryopreservation bag for stem cells.

[0025] Figure 4 This is a schematic diagram of the cross-sectional structure of a visual cryopreservation bag for stem cells.

[0026] Figure 5 This is a schematic diagram of the stem cell incubator.

[0027] Figure 6 This is a cross-sectional view of a stem cell incubator.

[0028] Figure 7 A schematic diagram of the structure of a stem cell incubator for containing a visible cryopreservation bag for stem cells.

[0029] The diagram is labeled as follows:

[0030] 1 is the bag body, 101 is the storage area, 2 is the cold source chamber, 201 is the first cold source chamber, 202 is the second cold source chamber, 3 is the drawstring part, 301 is the drawstring channel, 302 is the elastic cord, 4 is the cold source replacement inlet, 5 is the first label indicator area, 6 is the visible area, 7 is the outlet, 8 is the box body, 9 is the partition, 10 is the lid, 11 is the handle, 12 is the second label indicator area, and 13 is the insulation material. Detailed Implementation

[0031] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. This embodiment is based on the technical solution of the present invention and provides detailed implementation methods and specific operating procedures; however, the scope of protection of the present invention is not limited to the following embodiments.

[0032] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0033] The following detailed description of some embodiments of the present invention is provided in conjunction with the accompanying drawings. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0034] In the following embodiments, unless otherwise specified, the functional components or structures are conventional components or structures used in the art to achieve the corresponding functions.

[0035] Example 1

[0036] like Figures 1-4 As shown, a stem cell visual cryopreservation bag includes a bag body 1, a cold source cavity 2, and a drawstring 3. The bag body 1 has a storage area 101 for placing stem cell collection bags. The bag body 1 is a transparent bag or has a viewing area 6 on its side wall for observing the state of the stem cells inside the bag body 1. The cold source cavity 2 includes a first cold source cavity 201 located at the bottom inner side of the bag body 1 and a second cold source cavity 202 located on the inner side wall of the bag body 1 and communicating with the first cold source cavity 201. The drawstring 3 is located at the top opening of the bag body 1.

[0037] The storage area 101 consists of several units, such as... Figure 1 As shown, the bag 1 may contain only one storage area 101, which facilitates cryopreservation of stem cells when collecting small quantities. Figure 2 As shown, the bag 1 may contain multiple storage areas 101 to facilitate cryopreservation of stem cells when collecting large quantities of stem cells.

[0038] When there is more than one storage area 101, at least one sidewall of the storage area 101 must coincide with the sidewall of the bag body 1. The second cold source cavity 202 is located on the inner sidewall of the bag body 1 that coincides with the sidewall of the storage area 101, so that each storage area 101 can be in the low-temperature environment created by the first cold source cavity 201 and the second cold source cavity 202. Figure 5 As shown. The visible area 6 is located on the side wall of the bag 1 where the storage area 101 overlaps with the bag body 1, which facilitates observation of the state of stem cells in each storage area 101 at any time.

[0039] The outer wall of the bag body 1 is provided with a temperature indicator for displaying the temperature inside the bag body 1, so as to adjust the temperature inside the bag body 1 according to the temperature and keep the temperature inside the bag body 1 at a low temperature.

[0040] The outer wall of the bag 1 is provided with a first label indicator area 5, which facilitates the marking of the type of stem cells to be cryopreserved.

[0041] The drawstring portion 3 includes a drawstring channel 301 that is connected end-to-end and runs through the top opening edge of the bag body 1, and an elastic cord 302 disposed within the drawstring channel 301. The drawstring channel 301 has two holes, allowing the two ends of the elastic cord 302 to extend out from the holes. The size of the top opening of the bag body 1 can be adjusted by adjusting the length of the two ends of the elastic cord 302 outside the drawstring channel 301. Figures 1-3 As shown.

[0042] To maintain a consistently low temperature inside the bag 1, a cold source replacement inlet 4, communicating with the second cold source chamber 202, is provided on the outer wall of the bag 1. An outlet 7, communicating with the first cold source chamber (201), is also provided at the bottom of the bag, facilitating the periodic replacement of the cold source, such as ice water, in the first and second cold source chambers 201 and 202. When not being replaced, both the cold source replacement inlet 4 and the outlet 7 are closed.

[0043] Example 2

[0044] like Figures 5-7 As shown, a stem cell incubator includes a box body 8, several compartments 9 located inside the box body 8 for storing visible cryopreservation bags for stem cells, and a lid 10 for sealing the box body 8. The inner walls and bottom of the compartments 9 are lined with insulating material 13. The lid 10 has a handle 11 on the top. The outer wall of the box body 8 has a second label indicator area 12.

[0045] In this embodiment, the stem cell incubator can store various types of stem cells, which are then distinguished by marking them using the second label indicator area 12. When collecting large quantities of stem cells, stem cell collection bags of the same type can be stored in the same visible cryopreservation bag before being placed in section 9 of the stem cell incubator and marked again using the second label indicator area 12. Furthermore, staff can move the stem cell incubator at any time, facilitating the timely transfer of large quantities of stem cells to a suitable temperature for preservation.

[0046] The above description of the embodiments is provided to enable those skilled in the art to understand and use the utility model. It will be apparent to those skilled in the art that various modifications can be easily made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present utility model is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present utility model without departing from its scope should be within the protection scope of the present utility model.

Claims

1. A stem cell visual cryopreservation bag, characterized by, It includes a bag body (1), a cold source cavity (2), and a drawstring opening (3). The bag (1) is a transparent bag or the side wall of the bag (1) is provided with a visible area (6), and the bag (1) is provided with a storage area (101) for placing the stem cell collection bag; The cold source cavity (2) includes a first cold source cavity (201) located at the bottom of the inner side of the bag body (1) and a second cold source cavity (202) located on the inner side wall of the bag body (1) and communicating with the first cold source cavity (201); The drawstring portion (3) is located at the top opening of the bag body (1).

2. The stem cell visible cryopreservation bag of claim 1, wherein, The storage area (101) has several units.

3. The stem cell visible cryopreservation bag of claim 2, wherein, At least one sidewall of the storage area (101) coincides with the sidewall of the bag body (1), and the second cold source cavity (202) is disposed on the inner sidewall of the bag body (1) that coincides with the sidewall of the storage area (101).

4. The stem cell visible cryopreservation bag of claim 3, wherein, The visible area (6) is located on the side wall of the bag body (1) where the storage area (101) overlaps with the bag body (1).

5. The stem cell visible cryopreservation bag of claim 1, wherein, The outer wall of the bag (1) is provided with a temperature indicator for displaying the temperature inside the bag (1).

6. The stem cell visible cryopreservation bag of claim 1, wherein, The outer wall of the bag (1) is provided with a first label indication area (5).

7. The stem cell visible cryopreservation bag of claim 1, wherein, The drawstring portion (3) includes a drawstring channel (301) that is connected end to end and runs through the top opening edge of the bag body (1), and an elastic cord (302) disposed in the drawstring channel (301). The drawstring channel (301) has two holes, so that the two ends of the elastic cord (302) extend out from the holes respectively.

8. The stem cell visible cryopreservation bag of claim 1, wherein, The outer wall of the bag body (1) is also provided with a cold source replacement inlet (4) that communicates with the second cold source cavity (202), and the bottom of the bag body is also provided with an outlet (7) that communicates with the first cold source cavity (201).

9. A stem cell incubator, characterized by, It includes a box (8), several compartments (9) disposed inside the box (8) for storing the stem cell visual cryopreservation bag as described in any one of claims 1 to 8, and a lid (10) for closing the box (8). The inner sidewalls and bottom of the compartments (9) are covered with thermal insulation material (13), and the lid (10) has a handle (11) on the top.

10. The stem cell incubator of claim 9, wherein, The outer wall of the box (8) is provided with a second label indicator area (12).

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