Fermentation apparatus with foam containment

Abstract

The utility model relates to fermentation tank technical field, concretely relates to prevent foam overflow fermentation device, including fermentation tank, be equipped with the stirring shaft in the fermentation tank, be equipped with the stirring vane on the stirring shaft, the upper portion fixed of stirring shaft is equipped with the feeding spiral piece, and the feeding spiral piece is the netted structure, and is equipped with a plurality of meshes on it, and the top of fermentation tank is equipped with the foam collecting tube and the cyclone, and the bottom of foam collecting tube and cyclone bottom export links up with the inner chamber of fermentation tank respectively, and the top export of foam collecting tube connects venturi jet device negative pressure mouth, and the inlet of venturi jet device connects sterile gas pipe, and the export of venturi jet device connects cyclone inlet, and the top export of cyclone connects the gas holder through drying filter, and the gas outlet of gas holder connects the inlet of oil -free compressor, and the inlet of oil -free compressor still connects the gas cylinder, and the outlet of oil -free compressor connects the inlet of buffer tank, and the outlet of buffer tank connects sterile gas pipe through the bacterium -removing filter and check valve in proper order. The utility model does not need defoaming agent, and the foam is collected and eliminated in the aseptic environment efficiently.

Description

Technical Field

[0001] This utility model relates to the field of fermentation tank technology, specifically to a fermentation device that prevents foam overflow. Background Technology

[0002] In the microbial fermentation production of hyaluronic acid, a large amount of foam is generated due to microbial metabolism and mechanical stirring. If not properly controlled, this foam can overflow, resulting in the loss of both the microbial cells and the product, and increasing the risk of contamination. Using defoaming agents may inhibit microbial growth and make product purification difficult, while mechanical defoaming is relatively inefficient and ineffective. Utility Model Content

[0003] The technical problem to be solved by this utility model is to propose a fermentation device that prevents foam overflow, eliminates the need for defoaming agents, and efficiently collects and eliminates foam in a sterile environment.

[0004] The anti-foam overflow fermentation device of this utility model includes a fermentation tank, a stirring shaft inside the fermentation tank, stirring blades on the stirring shaft, a feeding spiral blade fixed on the upper part of the stirring shaft, the feeding spiral blade having a mesh structure with several mesh openings, a foam collecting cylinder and a hydrocyclone at the top of the fermentation tank, the bottom of the foam collecting cylinder and the bottom outlet of the hydrocyclone being connected to the inner cavity of the fermentation tank respectively, the top outlet of the foam collecting cylinder being connected to the negative pressure port of a Venturi jet, the inlet of the Venturi jet being connected to a sterile gas pipe, the outlet of the Venturi jet being connected to the inlet of the hydrocyclone, the top outlet of the hydrocyclone being connected to a gas storage tank through a drying filter, the gas outlet of the gas storage tank being connected to the inlet of an oil-free compressor, the inlet of the oil-free compressor being connected to a gas cylinder, the outlet of the oil-free compressor being connected to the inlet of a buffer tank, and the outlet of the buffer tank being connected to a sterile gas pipe in sequence through a sterilization filter and a one-way valve.

[0005] Preferably, the lower radial edge of the feeding auger is provided with a scraper, and the outer edge of the scraper is provided with spikes.

[0006] Preferably, the outer edge of the feeding spiral blades abuts against the inner wall of the fermenter.

[0007] Preferably, a wire mesh demister is provided at the top outlet of the hydrocyclone.

[0008] Preferably, the oil-free compressor inlet is equipped with a pre-filter.

[0009] Preferably, a pressure gauge is provided at the outlet of the buffer tank.

[0010] Preferably, the stirring blades are U-shaped.

[0011] Valves can be installed on the pipeline as needed to control the flow of materials within the pipeline. The opening and closing of the valves can be used to conveniently control the flow of materials within the pipeline and to regulate the material flow rate.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] 1. After foam is generated, it is guided upward by the feeding screw to enter the foam collecting cylinder. The mesh structure of the feeding screw is more conducive to separating foam and liquid. The liquid can be filtered out through the mesh. The gas in the sterile air tube guides the foam through the Venturi jet into the hydrocyclone. The foam is broken in the hydrocyclone, and gas and liquid are separated. The liquid flows back into the fermenter. The gas is dried and filtered and then enters the gas storage tank. The gas in the gas storage tank can be pressurized by the oil-free compressor (if the gas in the gas storage tank is insufficient, it can be supplemented by a gas cylinder). The pressurized gas enters the buffer tank. The pressurized gas in the buffer tank is sterilized by the sterilization filter and then enters the sterile air tube through the one-way valve as the driving gas for the Venturi jet.

[0014] 2. This utility model can efficiently collect foam. The collection of foam and gas-liquid separation are carried out in a sterile environment, which avoids contamination of the materials in the fermenter. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of the anti-foam overflow fermentation device of this utility model;

[0016] Figure 2 This is a schematic diagram of the stirring shaft structure;

[0017] Figure 3 This is a schematic diagram of the feeding spiral blade structure.

[0018] In the diagram: 1. Fermentation tank; 2. Agitator shaft; 3. Agitator blades; 4. Feeding spiral blade; 5. Mesh; 6. Foam collector; 7. Hydrocyclone; 8. Venturi jet injector; 9. Sterile air tube; 10. Dryer filter; 11. Gas storage tank; 12. Oil-free compressor; 13. Gas cylinder; 14. Buffer tank; 15. Sterilizing filter; 16. Check valve; 17. Scraper; 18. Spike; 19. Wire mesh demister; 20. Pre-filter; 21. Pressure gauge. Detailed Implementation

[0019] The present invention will now be described clearly and completely with reference to the accompanying drawings.

[0020] Example 1

[0021] like Figure 1As shown, the anti-foam overflow fermentation device of this utility model includes a fermentation tank 1, a stirring shaft 2 inside the fermentation tank 1, stirring blades 3 on the stirring shaft 2, the stirring blades 3 being U-shaped, a feeding spiral blade 4 fixedly mounted on the upper part of the stirring shaft 2, the feeding spiral blade 4 having a mesh structure with several meshes 5, a foam collecting cylinder 6 and a hydrocyclone 7 at the top of the fermentation tank 1, the bottom of the foam collecting cylinder 6 and the bottom outlet of the hydrocyclone 7 being respectively connected to the inner cavity of the fermentation tank 1, the top outlet of the foam collecting cylinder 6 being connected to the negative pressure port of a Venturi jet 8, the inlet of the Venturi jet 8 being connected to a sterile air tube 9, the outlet of the Venturi jet 8 being connected to the inlet of the hydrocyclone 7, the top outlet of the hydrocyclone 7 being connected to a gas storage tank 11 through a drying filter 10, the outlet of the gas storage tank 11 being connected to the inlet of an oil-free compressor 12, the inlet of the oil-free compressor 12 also being connected to a gas cylinder 13, the outlet of the oil-free compressor 12 being connected to the inlet of a buffer tank 14, and the outlet of the buffer tank 14 being connected to the sterile air tube 9 in sequence through a sterilization filter 15 and a one-way valve 16.

[0022] A wire mesh demister 19 is provided at the top outlet of the hydrocyclone 7.

[0023] The oil-free compressor 12 is equipped with a pre-filter 20 at its inlet.

[0024] Pressure gauge 21 is installed at the outlet of buffer tank 14.

[0025] The working process is as follows: The stirring shaft 2 rotates, driving the stirring blades 3 and the feeding screw 4 to rotate together. Foam is generated in the fermentation tank 1 and guided upward by the feeding screw 4 to the foam collection cylinder 6. The negative pressure is formed by the venturi jet 8 from the sterile gas tube 9. The foam is injected into the hydrocyclone 7 through the venturi jet 8. The foam is broken and separated into gas and liquid in the hydrocyclone 7. The liquid flows back into the fermentation tank 1. The gas is further removed by the wire mesh demister 19 and then passes through the dryer filter 10 and enters the gas storage tank 11. The gas in the gas storage tank 11 is further removed by the pre-filter 20 and then enters the oil-free compressor 12 for pressurization. When the gas in the gas storage tank 11 is insufficient, the gas in the gas cylinder 13 can be used as the gas source. The pressurized gas enters the buffer tank 14. The gas in the buffer tank 14 is sterilized by the sterilization filter 15 to obtain sterile high-pressure gas. The sterile gas enters the sterile gas tube 9 through the one-way valve 16 as the driving gas of the venturi jet 8.

[0026] Example 2

[0027] Based on Example 1, such as Figure 2 , Figure 3 As shown, a scraper 17 is provided on the lower radial edge of the feeding spiral blade 4, and spikes 18 are provided on the outer edge of the scraper 17. When the feeding spiral blade 4 rotates, it drives the scraper 17 and spikes 18 to rotate. The scraper 17 can more easily guide the foam to the feeding spiral blade 4, and the spikes 18 can help puncture the foam and eliminate some of the foam.

[0028] The outer edge of the feeding spiral blade 4 abuts against the inner wall of the fermentation tank 1, which allows more foam to be guided to the foam collection cylinder 6.

Claims

1. A fermentation device for preventing foam overflow, comprising a fermentation tank (1), wherein a stirring shaft (2) is provided inside the fermentation tank (1), and stirring blades (3) are provided on the stirring shaft (2), characterized in that, A feeding spiral blade (4) is fixedly installed on the upper part of the stirring shaft (2). The feeding spiral blade (4) has a mesh structure with several mesh openings (5). A foam collecting cylinder (6) and a hydrocyclone (7) are installed on the top of the fermentation tank (1). The bottom of the foam collecting cylinder (6) and the bottom outlet of the hydrocyclone (7) are respectively connected to the inner cavity of the fermentation tank (1). The top outlet of the foam collecting cylinder (6) is connected to the negative pressure port of the Venturi jet (8). The inlet of the Venturi jet (8) is connected to the sterile air tube (9). The outlet of the device (8) is connected to the inlet of the hydrocyclone (7). The top outlet of the hydrocyclone (7) is connected to the gas storage tank (11) through the dryer filter (10). The outlet of the gas storage tank (11) is connected to the inlet of the oil-free compressor (12). The inlet of the oil-free compressor (12) is also connected to the gas cylinder (13). The outlet of the oil-free compressor (12) is connected to the inlet of the buffer tank (14). The outlet of the buffer tank (14) is connected to the sterile air tube (9) through the sterile filter (15) and the one-way valve (16) in sequence.

2. The anti-foam overflow fermentation device according to claim 1, characterized in that, The lower radial edge of the feeding spiral blade (4) is provided with a scraper (17), and the outer edge of the scraper (17) is provided with spikes (18).

3. The anti-foam overflow fermentation device according to claim 1, characterized in that, The outer edge of the feeding spiral blade (4) abuts against the inner wall of the fermentation tank (1).

4. The anti-foam overflow fermentation device according to claim 1, characterized in that, A wire mesh demister (19) is provided at the top outlet of the hydrocyclone (7).

5. The anti-foam overflow fermentation device according to claim 1, characterized in that, The oil-free compressor (12) is equipped with a pre-filter (20) at its inlet.

6. The anti-foam overflow fermentation device according to claim 1, characterized in that, A pressure gauge (21) is installed at the outlet of the buffer tank (14).

7. The anti-foam overflow fermentation device according to claim 1, characterized in that, The stirring blade (3) is U-shaped.

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