A new mouse corneal alkali burn modeling tool

Abstract

The utility model relates to mouse cornea modeling experiment technical field, especially a kind of novel mouse cornea alkali burn molding tool, the utility model is provided with adsorption ring, lye introduction pipe, drain pipe and negative pressure pipe, adsorption ring includes hollow ring body, the adsorption end for being set in the bottom of hollow ring body to be consistent with mouse cornea surface and form alkali liquor storage area, the liquid drop port being set on the central axis of hollow ring body and being penetrated through hollow region and the drain port being set on the inner wall of hollow region in adsorption end, the shell inside hollow ring body is provided with import channel, drain channel and negative pressure channel, the end face of adsorption end and mouse cornea contact is provided with several adsorption holes, each adsorption hole is connected with the end of negative pressure channel close to hollow region, and then, realized the stable flat adsorption of adsorption ring and cornea contact surface, improved the uniformity of alkali liquor distribution in mouse cornea, and realized the injection and suction of precise control alkali liquor.

Description

Technical Field

[0001] This utility model relates to the field of mouse corneal modeling experimental technology, and in particular to a novel tool for modeling mouse corneal alkali burns. Background Technology

[0002] Alkali burns are a common and challenging type of ocular burn. Alkaline substances have strong penetrating and destructive properties to ocular tissues, leading to complications such as corneal ulcers, perforations, and symblepharon, severely impacting vision. Therefore, constructing accurate and reliable animal models of corneal alkali burns is crucial for in-depth research into the pathological mechanisms of alkali burns, exploring treatment methods, and developing drugs. Traditional methods for creating corneal alkali burn models, such as applying filter paper soaked in alkali solution to the cornea, struggle to precisely control the contact area, time, and amount of alkali with the cornea, potentially leading to inconsistent modeling results. With the continuous advancement of medical and biological research, the requirements for the quality and precision of experimental animal models are increasing, necessitating more advanced modeling tools and techniques to meet research needs. The development of equipment such as microinfusion pumps and negative pressure generators provides technical support for the design of novel modeling tools.

[0003] For example, Chinese Patent Publication No. CN216091021U discloses a device for assisting drug delivery during corneal cross-linking surgery. The device includes a negative pressure adsorption section with an overall ring-shaped structure. The negative pressure adsorption section has an internal air cavity and a ventilation port communicating with the internal air cavity. The lower end of the internal air cavity has an opening. The negative pressure adsorption section forms an ocular surface contact portion at the opening, suitable for contacting the surface of the eyeball. When air is drawn through the ventilation port to generate negative pressure within the internal air cavity, the negative pressure adsorption section adheres to the eyeball through the ocular surface contact portion, forming a reservoir surrounding a region of the eyeball surface.

[0004] The existing technology also has the following problems: it does not take into account the unevenness of the corneal contact surface caused by negative pressure, which affects the uniformity of the distribution of alkali solution in the mouse cornea, and it cannot accurately control the injection and aspiration of alkali solution. Utility Model Content

[0005] Therefore, this utility model provides a novel mouse corneal alkali burn modeling tool to overcome the problems of uneven corneal contact surface caused by negative pressure adsorption in the existing technology, which affects the uniformity of alkali distribution in the mouse cornea, and the inability to accurately control the injection and aspiration of alkali.

[0006] To achieve the above objectives, this utility model provides a novel tool for creating a mouse corneal alkali burn model, comprising: The adsorption ring includes a hollow ring body, an adsorption end disposed at the bottom of the hollow ring body to fit with the surface of the mouse cornea to form an alkaline storage area, a droplet outlet disposed on the central axis of the hollow ring body through the hollow area, and a drain outlet disposed on the inner wall of the hollow area of ​​the adsorption end. The hollow annular shell is provided with an inlet channel, a drain channel, and a negative pressure channel inside its shell. The drip outlet is connected to one end of the inlet channel near the hollow region via a guide tube; The adsorption end is provided with several adsorption holes on the end face that contacts the mouse cornea, and each adsorption hole is connected to one end of the negative pressure channel near the hollow region. An alkaline solution inlet tube is connected to the outer wall of the shell of the adsorption ring and communicates with the inlet channel; A drain pipe, one end of which is connected to the outer wall of the shell of the adsorption ring and communicates with the drain channel; The negative pressure tube is connected to the outer wall of the shell of the adsorption ring and extends through the far end of the negative pressure channel from the hollow region.

[0007] Furthermore, the adsorption ring has four drainage ports, and the angle between the line connecting the adjacent drainage ports and the central axis of the hollow region is ninety degrees.

[0008] Furthermore, the drain outlet is connected to the drain channel.

[0009] Furthermore, the height of the droplet outlet from the adsorption end is one-third of the total height of the hollow ring.

[0010] Furthermore, each adsorption pore is evenly distributed on the annular end face that contacts the mouse cornea, and the adsorption pores are circular in shape.

[0011] Furthermore, a planar contact pad is provided on the contact surface between the adsorption hole and the mouse cornea, and the surface of the planar contact pad is distributed with a plurality of holes penetrating the planar contact pad.

[0012] Furthermore, the alkali inlet tube is connected to a micro pump for controlling the amount of alkali pumped in.

[0013] Furthermore, the micro-pump is also connected to a control switch and a timer. The control switch is used to control the micro-pump to start and trigger the timer to start timing.

[0014] Furthermore, the drain pipe is connected to an aspirator for drawing out the alkaline solution from the adsorption ring.

[0015] Furthermore, the negative pressure tube is also connected to a negative pressure generator for generating negative pressure.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows: This utility model is equipped with an adsorption ring, an alkali inlet tube, a drain tube, and a negative pressure tube. The adsorption ring includes a hollow ring body, an adsorption end located at the bottom of the hollow ring body to fit with the surface of the mouse cornea to form an alkali storage area, a droplet located on the central axis of the hollow ring body through the hollow area, and a drain outlet located on the inner wall of the hollow area of ​​the adsorption end. The shell of the hollow ring body is provided with an inlet channel, a drain channel, and a negative pressure channel. The end face of the adsorption end that contacts the mouse cornea is provided with a number of adsorption holes. Each adsorption hole is connected to the end of the negative pressure channel near the hollow area. Thus, stable and flat adsorption between the adsorption ring and the corneal contact surface is achieved, the uniformity of alkali distribution in the mouse cornea is improved, and precise control of alkali injection and aspiration is achieved.

[0017] In particular, this invention ensures that the alkali solution drips from the center by setting a drip outlet on the central axis of the hollow ring that runs through the hollow region, and the dripping alkali solution naturally diffuses to the surrounding areas, thus achieving a uniform distribution of the alkali solution on the mouse cornea.

[0018] In particular, by setting multiple drain ports at uniform angle intervals, this utility model allows the alkali solution to flow out simultaneously from different directions, avoiding the problems of incomplete alkali discharge and different retention times of alkali solution in different areas caused by alkali solution flowing out from only one direction, and achieving precise control of alkali solution extraction.

[0019] In particular, the adsorption hole of this invention has a flat contact pad on the contact surface between it and the mouse cornea. It is understood that when negative pressure generates suction through the adsorption hole, local wrinkles are easily formed around the adsorption hole, affecting the uniformity of the alkaline solution distribution within the adsorption ring. By setting the flat contact pad, the flat contact pad acts as a buffer between the adsorption hole and the cornea. The pores on the surface allow the negative pressure to pass through the contact pad more evenly and act on the cornea, making the suction force on each part of the cornea more uniform and avoiding wrinkles caused by excessive local pressure. Thus, stable and flat adsorption between the adsorption ring and the cornea contact surface is achieved.

[0020] In particular, this invention connects a micro-pump to a timer, accurately records the alkali injection time of the micro-pump, and precisely controls the alkali injection volume, thus achieving precise control of alkali injection and extraction. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the structure of the novel mouse corneal alkali burn modeling tool according to an embodiment of the present invention; Figure 2 This is a schematic diagram of the internal structure of the adsorption ring in an embodiment of the present invention; Figure 3 This is a schematic diagram of the planar contact pad according to an embodiment of the present invention; In the diagram, 1. Hollow ring, 2. Adsorption end, 3. Droplet, 4. Drain, 5. Inlet channel, 51. Alkali inlet tube, 6. Drain channel, 61. Drain tube, 7. Negative pressure channel, 71. Negative pressure tube, 8. Guide tube, 9. Adsorption hole, 10. Flat contact pad, 11. Hole, 12. Micro pump, 13. Suction device, 14. Negative pressure generator, 15. Contact surface between the adsorption hole and the mouse cornea. Detailed Implementation

[0022] To make the objectives and advantages of this utility model clearer, the utility model will be further described below with reference to the embodiments; it should be understood that the specific embodiments described herein are only for explaining this utility model and are not intended to limit this utility model.

[0023] Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are merely illustrative of the technical principles of the present invention and are not intended to limit the scope of protection of the present invention.

[0024] It should be noted that in the description of this utility model, the terms "upper", "lower", "inner", "outer", etc., indicating the direction or positional relationship are based on the direction or positional relationship shown in the drawings. This is only for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this utility model.

[0025] Furthermore, it should be noted that, in the description of this utility model, unless otherwise explicitly specified and limited, the terms "installation" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0026] Please see Figure 1 as well as Figure 2 As shown, Figure 1 This is a schematic diagram of the structure of the novel mouse corneal alkali burn modeling tool according to an embodiment of this utility model. Figure 2 This is a schematic diagram of the internal structure of the adsorption ring in an embodiment of the present invention. The present invention provides a novel mouse corneal alkali burn modeling tool, comprising: The adsorption ring includes a hollow ring body 1, an adsorption end 2 disposed at the bottom of the hollow ring body 1 to fit with the surface of the mouse cornea to form an alkaline storage area, a drop outlet 3 disposed on the central axis of the hollow ring body 1 through the hollow area, and a drain outlet 4 disposed on the inner wall of the hollow area of ​​the adsorption end 2. The hollow ring 1 is provided with an inlet channel 5, a drain channel 6 and a negative pressure channel 7 inside the shell. The drip outlet 3 is connected to one end of the inlet channel 5 near the hollow region via a guide tube 8; The adsorption end 2 is provided with a plurality of adsorption holes 9 on the end face that contacts the mouse cornea, and each adsorption hole 9 is connected to one end of the negative pressure channel 7 near the hollow region. The alkaline solution inlet tube 51 is connected to the outer wall of the shell of the adsorption ring and communicates with the inlet channel 5. The drain pipe 61 has one end connected to the outer wall of the shell of the adsorption ring and communicates with the drain channel 6; The negative pressure tube 71 is connected to the outer wall of the shell of the adsorption ring and extends through the far end of the negative pressure channel 7 from the hollow region.

[0027] Specifically, this invention ensures that the alkali solution drips from the center of the hollow ring 1 along the central axis of the hollow region, and the dripping alkali solution naturally diffuses to the surrounding area, thus achieving a uniform distribution of the alkali solution on the mouse cornea.

[0028] Specifically, the adsorption ring has four drain ports 4, and the angle between the line connecting the adjacent drain ports 4 and the central axis of the hollow region is 90 degrees.

[0029] Specifically, this invention uses multiple drain ports 4 spaced at uniform angles to allow the alkali solution to flow out simultaneously from different directions. This avoids the problems of incomplete alkali discharge and differences in alkali retention time in different areas caused by alkali solution flowing out from only one direction, and achieves precise control of alkali solution extraction.

[0030] Specifically, the drain port 4 is connected to the drain channel 6.

[0031] Specifically, the height of the droplet 3 from the adsorption end 2 is one-third of the total height of the hollow ring.

[0032] Specifically, each adsorption pore is evenly distributed on the annular end face of the adsorption end 2 that contacts the mouse cornea, and the adsorption pore 9 is circular in shape.

[0033] Please see Figure 3 As shown, it is a schematic diagram of the planar contact pad of the present invention. Specifically, the contact surface 15 between the adsorption hole 9 and the mouse cornea is provided with a planar contact pad 10, and the surface of the planar contact pad 10 is distributed with a plurality of holes 11 penetrating the planar contact pad 10.

[0034] Specifically, the contact surface 15 between the adsorption hole and the mouse cornea of ​​this invention is provided with a flat contact pad 10. It can be understood that when negative pressure generates suction through the adsorption hole 9, local wrinkles are easily formed around the adsorption hole 9, affecting the uniformity of the alkaline solution distribution in the adsorption ring. By providing the flat contact pad 10, the flat contact pad 10 plays a buffering role between the adsorption hole 9 and the cornea. The holes 11 on the surface allow the negative pressure to pass through the contact pad more evenly and act on the cornea, making the suction force on each part of the cornea more uniform, avoiding the wrinkling phenomenon caused by excessive local pressure, and thus achieving stable and flat adsorption between the adsorption ring and the cornea contact surface.

[0035] Specifically, the alkali inlet tube 51 is connected to a micro pump 12 for controlling the amount of alkali pumped in.

[0036] Specifically, the micro-pump 12 is also connected to a control switch and a timer. The control switch is used to control the micro-pump 12 to start and to trigger the timer to start timing.

[0037] In practice, the micro-pump can be an injection pump or a CNC micro-pump. Preferably, a CNC micro-pump can be used to precisely control the operation of the motor through a microprocessor, thereby precisely controlling the amount of alkali solution introduced.

[0038] This utility model does not limit the specific structure of the timer. Preferably, it can be an electronic timer with a display screen and operation buttons. The built-in control circuit can receive signals from the control switch and perform timing. Further details will not be provided here.

[0039] This utility model does not limit the specific structure of the control switch, which can be one of a push-button switch, a rotary switch or a touch switch, to realize the operation control of starting and stopping the micro pump, and to trigger the counter to start and stop timing. Control switches are widely used in the field of electrical control, and will not be described in detail here.

[0040] Specifically, this invention connects the micro-pump 12 to a timer, accurately records the alkali pumping time of the micro-pump 12, precisely controls the amount of alkali pumped in, and achieves precise control of alkali injection and extraction.

[0041] Specifically, the drain pipe 61 is connected to an aspirator 13 for drawing out the alkaline solution from the adsorption ring.

[0042] In practice, the suction device can be a vacuum pump, which generates negative pressure to collect the alkaline solution on the surface of the mouse cornea into a collection container through the drainage port, drainage channel and drainage tube, which will not be described in detail here.

[0043] Specifically, the negative pressure tube 71 is also connected to a negative pressure generator 14 used to generate negative pressure.

[0044] In practice, the negative pressure generator can be an electric negative pressure pump, which can precisely adjust the magnitude of the negative pressure according to the set parameters. This is existing technology and will not be elaborated here.

[0045] Specifically, in practice, the negative pressure generated by the negative pressure generator 14 is transmitted to the adsorption hole 9 on the adsorption end 2 through the negative pressure tube 71 and the negative pressure channel 7, so that the adsorption end fits with the surface of the mouse cornea to form a stable alkaline storage area. The micro pump 12 is started by controlling the control switch and triggering the timer to start timing. The micro pump 12 introduces the alkaline solution into the alkaline storage area on the surface of the mouse cornea through the alkaline solution introduction tube 51, the introduction channel 5 and the drop outlet 3. When the timer reaches the set time value, the control switch controls the micro pump to turn off, ensuring that the amount of alkaline solution introduced into the surface of the mouse cornea by the micro pump is constant each time. After the alkaline solution has been in effect on the mouse cornea for the set time, the suction device 13 is turned on. The alkaline solution on the surface of the mouse cornea is suctioned out through the drain outlet 4, the drain channel 6 and the drain tube 61 by the suction device 13, thus completing the construction of the experimental model of alkali burn of the mouse cornea.

[0046] The technical solution of this utility model has been described above with reference to the preferred embodiments shown in the accompanying drawings. However, it will be readily understood by those skilled in the art that the protection scope of this utility model is obviously not limited to these specific embodiments. Without departing from the principle of this utility model, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will all fall within the protection scope of this utility model.

[0047] The above description is merely a preferred embodiment of this utility model and is not intended to limit the scope of this utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A novel tool for creating a mouse corneal alkali burn model, characterized in that, include: The adsorption ring includes a hollow ring body, an adsorption end disposed at the bottom of the hollow ring body to fit with the surface of the mouse cornea to form an alkaline storage area, a droplet outlet disposed on the central axis of the hollow ring body through the hollow area, and a drain outlet disposed on the inner wall of the hollow area of ​​the adsorption end. The hollow annular shell is provided with an inlet channel, a drain channel, and a negative pressure channel inside its shell. The drip outlet is connected to one end of the inlet channel near the hollow region via a guide tube; The adsorption end is provided with several adsorption holes on the end face that contacts the mouse cornea, and each adsorption hole is connected to one end of the negative pressure channel near the hollow region. An alkaline solution inlet tube is connected to the outer wall of the shell of the adsorption ring and communicates with the inlet channel; A drain pipe, one end of which is connected to the outer wall of the shell of the adsorption ring and communicates with the drain channel; The negative pressure tube is connected to the outer wall of the shell of the adsorption ring and extends through the far end of the negative pressure channel from the hollow region.

2. The novel mouse corneal alkali burn modeling tool according to claim 1, characterized in that, The adsorption ring has four drain ports, and the angle between the line connecting the adjacent drain ports and the central axis of the hollow region is 90 degrees.

3. The novel mouse corneal alkali burn modeling tool according to claim 2, characterized in that, The drain outlet is connected to the drain channel.

4. The novel mouse corneal alkali burn modeling tool according to claim 1, characterized in that, The height of the droplet outlet from the adsorption end is one-third of the total height of the hollow ring.

5. The novel mouse corneal alkali burn modeling tool according to claim 1, characterized in that, Each adsorption pore is evenly distributed on the annular end face that contacts the mouse cornea, and the adsorption pores are circular in shape.

6. The novel mouse corneal alkali burn modeling tool according to claim 5, characterized in that, A flat contact pad is provided on the contact surface between the adsorption hole and the mouse cornea. The surface of the flat contact pad is distributed with several holes that penetrate the flat contact pad, so that the adsorption ring can be stably and flatly adsorbed on the contact surface of the cornea.

7. The novel mouse corneal alkali burn modeling tool according to claim 1, characterized in that, The alkali inlet tube is connected to a micro pump used to control the amount of alkali pumped in.

8. The novel mouse corneal alkali burn modeling tool according to claim 7, characterized in that, The micro-pump is also connected to a control switch and a timer. The control switch is used to control the micro-pump to start and to trigger the timer to start timing.

9. The novel mouse corneal alkali burn modeling tool according to claim 1, characterized in that, The drain pipe is connected to an aspirator for drawing out the alkaline solution from the adsorption ring.

10. The novel mouse corneal alkali burn modeling tool according to claim 1, characterized in that, The negative pressure tube is also connected to a negative pressure generator used to generate negative pressure.

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