Carbamoyl lipid with a cyclic group in the side chain, lipid nanoparticle thereof, and pharmaceutical composition thereof

Abstract

The present inventors have discovered a carbamoyl lipid with a cyclic group in a side chain capable of forming a lipid nanoparticle and clarified that a lipid nanoparticle containing the carbamoyl lipid with a cyclic group in a side chain of the invention as a component can express a protein in an astrocyte or hepatocyte. Furthermore, a lipid nanoparticle containing the carbamoyl lipid with a cyclic group in a side chain of the invention as a component should be a component of a pharmaceutical composition that encapsulates a nucleic acid and is useful for the prevention and / or treatment of an astrocyte-related disease.