TRANSFORMING GROWTH FACTOR BETA-RESPONSIVE POLYPEPTIDES AND METHODS OF USING THEM

Abstract

Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen binding domain that specifically binds to a TGF-β, a spacer peptide, a transmembrane domain, and an endodomain. When expressed in a cell, they are capable of not only neutralizing TGF-β but also specifically triggering T-cell activation in the presence of TGF-β. T-cell activation induces the immune cell to produce immunostimulatory cytokines and to proliferate, thereby converting TGF-β from an immunosuppressive signal to an activating stimulus.