Cosmetic product containing adenosine

Abstract

The application relates to an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.% and adenosine in an amount of 0.05 to 3 wt.%, wherein the hair tonic has less than 18 wt.%, preferably a maximum of 10 wt.%, in particular a maximum of 5 wt.% ethanol, and the use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18 wt.% for the cosmetic treatment of the skin, in particular the scalp.

Description

[0001] The invention is an invention in the field of hair tonics. It relates to sprayable aqueous products containing adenosine and having skin and hair conditioning effects.

[0002] The present invention relates to a hair tonic with hair-conditioning effects, such as preventing hair loss and promoting hair growth. Adenosine is an active ingredient used in various cosmetic preparations, such as hair tonics, to prevent hair loss and promote hair growth. For ease of use, such products are preferably sprayed onto the scalp and hair and should be applied without weighing the hair down.

[0003] It is desirable to be able to use high concentrations of adenosine in these products to achieve a satisfactory effect for the user. High concentrations between 0.1 and 1.5 wt% adenosine can currently only be achieved in sprayable products with an ethanol content of at least 20 wt%. Adenosine cannot be stably incorporated into sprayable products with a lower ethanol content. However, products with such a high alcohol content lead to severe drying of the consumer's scalp and accelerated fading of colored hair. Therefore, it is desirable to provide a product that overcomes these disadvantages.

[0004] The aim of the present invention was therefore to provide stable sprayable aqueous agents in which adenosine is present in a high concentration and which do not dry out the scalp.

[0005] Surprisingly, it was found that this task can be solved with a composition containing urea or a urea derivative and adenosine.

[0006] A first object of the present application is therefore an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.% and adenosine in an amount of 0.05 to 3 wt.%, characterized in that the hair tonic contains less than 18 wt.%, preferably a maximum of 10 wt.%, in particular a maximum of 5 wt.% ethanol.

[0007] The urea derivative can be used in combination with or instead of urea, maintaining a total amount of 1.0 to 20 wt.%. If a urea derivative is used, it is preferably 2-hydroxyethylurea. In these cases, 2-hydroxyethylurea is preferably used in amounts of 1.0 to 15 wt.%, particularly preferably in amounts of 2.0 to 7.0 wt.%, and especially 2.0 to 5.0 wt.%. Preferably, 2-hydroxyethylurea is used in combination with urea. In these cases, the preferred amount of urea is 0.05 to 3.0 wt.%, particularly preferably 0.1 to 1.0 wt.%, and especially 0.1 to 0.5 wt.%, and the preferred amount of 2-hydroxyethylurea is 1.0 to 15 wt.%, particularly preferably 1.5 to 7 wt.%, and especially 2.0 to 5.0 wt.%. In such combinations, the ratio of 2-hydroxyethylurea to urea is particularly preferably between 20:1 and 10:1.

[0008] A preferred product is therefore a aforementioned hair tonic, wherein the urea derivative is 2-hydroxyethylurea.

[0009] Another preferred item is a hair tonic of the aforementioned type, wherein the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 7.0 wt.%, more preferably 2.0 to 5.0 wt.%.

[0010] The claimed hair tonic contains adenosine in an amount of 0.05 to 3 wt.%. Adenosine is a nucleotide and consists of the nucleobase adenine and the sugar β-D-ribose. Preferred compositions contain adenosine in an amount of 0.1 to 2 wt.%, particularly 0.1 to 1 wt.%. Furthermore, compositions containing adenosine in amounts of 0.2 to 1.5 wt.%, particularly 0.5 to 1.0 wt.%, may be preferred.

[0011] It is therefore a preferred item if the hair tonic contains adenosine in an amount of 0.1 to 2 wt.%, in particular 0.1 to 1 wt.%.

[0012] The claimed hair tonic contains adenosine as an active ingredient. The hair tonic may also contain adenosine derivatives, such as adenosine 5'-phosphate. It is preferred that the claimed composition contains only a limited amount of adenosine derivatives, such as adenosine 5'-phosphate, e.g., adenosine monophosphate (INCI: Adenosine Phosphate), adenosine diphosphate, and / or adenosine triphosphate (INCI: Adenosine Triphosphate). It is preferred that the composition contains less than 0.5% by weight, particularly less than 0.2% by weight, and especially less than 0.1% by weight, of the group of adenosine phosphates. In particular, it may be preferred that the composition is free of adenosine phosphates. In this context, "free from adenosine phosphates" means that adenosine phosphates are neither added as a separate ingredient nor introduced into the claimed product via preparations of other ingredients, such as in quantities of up to 0.001 wt.-% based on the total mass of the medium.

[0013] The claimed hair tonic contains less than 18 wt%, preferably a maximum of 10 wt%, and particularly a maximum of 5 wt% ethanol. A preferred article is a hair tonic as described above, which contains 5.0 to 10.0 wt% ethanol. Another preferred article is a hair tonic as described above, which contains a maximum of 5 wt%, particularly preferably less than 1 wt%, and particularly preferably less than 0.5 wt%, ethanol, or which is free of ethanol. In this context, "free of ethanol" means that ethanol is neither added as a separate ingredient nor introduced into the claimed agent via preparations of other ingredients, such as in amounts of up to 2 wt% based on the total mass of the agent.

[0014] A preferred object is therefore an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.% and ethanol in an amount of 5.0 to 10 wt.%.

[0015] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.% and ethanol in an amount of 5.0 to 10 wt.%.

[0016] The claimed aqueous sprayable hair tonic can be easily applied to the relevant areas by the user, as it is sprayable and therefore finely and evenly distributed. To ensure good sprayability, the hair treatment composition according to the invention is preferably free of viscosity-increasing ingredients such as the polyquaternium polymers known under the INCI names Polyquaternium-10 and Polyquaternium-37, insofar as this is compatible with economical operation. Such and comparable viscosity-increasing ingredients are preferably present in the hair treatment composition according to the invention at a maximum of 2% by weight, more preferably at a maximum of 0.5% by weight, and particularly preferably at a maximum of 0.1% by weight.-% based on the total weight of the hair treatment composition.

[0017] According to the invention, it is preferred that the claimed hair tonic preferably has a viscosity of at most 150 mPa*s, particularly preferably of 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s, measured with Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM) to ensure good sprayability.

[0018] A preferred article is therefore a claimed hair tonic as described above, which has a viscosity of at most 150 mPa*s, particularly preferably of 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s, measured with Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM).

[0019] The aqueous formulations contain a certain proportion of water. Formulations containing water in an amount of 50 to 99 wt.%, particularly preferably 65 to 95 wt.%, and especially 70 to 90 wt.%, are preferred. The water primarily serves to adjust the concentrations of the previously defined ingredients to a range suitable for the aqueous, sprayable hair tonic.

[0020] The claimed hair tonic may contain one or more excipients. These optional excipients can further stabilize hair tonics with a very low ethanol content. A preferred object is therefore a hair tonic containing at least one excipient from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof. A further preferred object is a hair tonic as described above, comprising a maximum of 5% by weight, particularly preferably less than 1% by weight, and especially preferably less than 0.5% by weight, of ethanol and at least one excipient from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof.

[0021] Hair tonics containing such excipients preferably have these excipients in a total amount of 0.5 to 35 wt.%, preferably up to 25 wt.%, in particular up to 15 wt.%.

[0022] A preferred article is therefore an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of less than 18 wt.% and preferably a maximum of 5 wt.%, particularly preferably less than 1 wt.%, and particularly preferably less than 0.5 wt.%, and at least one excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof, preferably in an amount of 0.5 to 25 wt.%, particularly preferably up to 15 wt.%, and particularly up to 10 wt.%.

[0023] A preferred article is therefore a claimed hair tonic which additionally contains at least one diol as an optional excipient. The diol may preferably be ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol, or dipropylene glycol, or mixtures thereof. If at least one diol is used as an excipient, this diol or the mixture of several diols is preferably present in a total amount of 0.5 to 20 wt.% in the claimed composition. The diol is particularly preferably 1,2-propylene glycol and / or 1,2-pentylene glycol. If 1,2-propylene glycol is used as an excipient, it is preferably present in an amount of 2 to 20 wt.%, and particularly preferably 3 to 15 wt.%, in the claimed composition. If 1,2-pentylene glycol is used as an auxiliary substance, it is preferably contained in an amount of 0.5 to 5 wt.%, particularly preferably 1 to 3.5 wt.%, in the claimed composition.

[0024] A preferred article is therefore an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.%, and 1,2-propylene glycol, preferably in an amount of 2 to 20 wt.%, particularly preferably 3 to 15 wt.%.

[0025] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and 1,2-propylene glycol, preferably in an amount of 2 to 20 wt.%, particularly preferably 3 to 15 wt.%.

[0026] A particularly preferred object is an aqueous sprayable hair tonic containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and 1,2-propylene glycol, preferably in an amount of 3 to 15 wt.%.

[0027] A preferred object is therefore also an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of a maximum of 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and 1,2-pentylene glycol, preferably in an amount of 0.5 to 5 wt.%, particularly preferably 1 to 3.5 wt.%.

[0028] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and 1,2-pentylene glycol preferably in an amount of 0.5 to 5 wt.%, particularly preferably 1 to 3.5 wt.%.

[0029] A particularly preferred article is an aqueous sprayable hair tonic containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 10.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and 1,2-pentylene glycol preferably in an amount of 1 to 3.5 wt.%.

[0030] Another preferred article is therefore a claimed hair tonic which additionally contains at least one polyethylene glycol as an optional excipient. The polyethylene glycol may preferably be one or more compounds from the group according to formula HO-[CH2CH2O] x-H, where x represents an integer from 2 to 100, preferably 2 to 80, more preferably 2 to 60, and even more preferably 3 to 40 or 4 to 20. If a polyethylene glycol is used as an optional excipient, this polyethylene glycol or a mixture of several polyethylene glycols is preferably present in the claimed composition in a total amount of 0.5 to 15 wt.%. The polyethylene glycol to be used optionally is particularly preferably one in which x represents an integer from 3 to 40. If this is used, it is preferably present in the claimed composition in an amount of 0.5 to 15 wt.%, particularly preferably in an amount of 5.0 to 10 wt.%.

[0031] It is also possible to use mixtures of the aforementioned optional excipients as optional excipients. If an optional excipient is used, it is further preferred to use a combination of 1,2-propylene glycol and PEG-40, i.e., a polyethylene glycol of the formula given above, where x = 40 (INCI: PEG-40 Hydrogenated Castor Oil). It is particularly preferred if 1,2-propylene glycol is used in an amount of 1.0 to 15 wt% and PEG-40 in an amount of 0.3 to 5.0 wt%.

[0032] Another preferred article is therefore a claimed hair tonic which additionally contains at least one glycol ether as an optional excipient. The glycol ether may preferably be one or more compounds from the group consisting of monomethyl ethers, monoethyl ethers, and monopropyl ethers, as well as mixtures thereof. If a glycol ether is used as an optional excipient, it is preferably present in a total amount of 0.5 to 15 wt.% in the claimed composition. The optionally used glycol ether is particularly preferably diethylene glycol monoethyl ether. If this is used, it is preferably present in an amount of 0.5 to 15 wt.%, and particularly preferably in an amount of 5.0 to 10 wt.%, in the claimed composition.

[0033] Another preferred article is therefore a claimed hair tonic which additionally contains glycerin as an optional excipient. If glycerin is used as an optional excipient, it is preferably present in an amount of 0.5 to 15 wt.%, and particularly preferably in an amount of 3.0 to 10 wt.% in the claimed composition.

[0034] Another preferred article is therefore a claimed hair tonic which additionally contains at least one polymerized glycerol derivative as an optional excipient. The polymerized glycerol derivative may be at least one of the polymerized glycerol derivatives or mixtures thereof known under the INCI names polyglyceryl-6 caprylate, polyglyceryl-4 caprate, polyglyceryl-3 cocoate, polyglyceryl-6 ricinoleate, or polyglyceryl-3 caprate / caprylate / succinate. If at least one polymerized glycerol derivative is used as an optional excipient, this polymerized glycerol derivative is preferably present in the claimed composition in a total amount of 0.3 to 15 wt.%, particularly preferably 2 to 10 wt.%, and especially 5 to 9 wt.%. The polymerized glycerol derivative to be used optionally is particularly preferably a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate.When this mixture is used, it is preferably contained in a total amount of 0.1 to 15 wt.%, particularly preferably 0.3 to 10 wt.%, and especially 0.5 to 9 wt.% in the claimed agent.

[0035] A preferred article is therefore also an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate preferably in a total amount of 1 to 15 wt.%, particularly preferably 2 to 10 wt.%, and in particular 5 to 9 wt.%.

[0036] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, in particular less than 0.5 wt.% and a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate preferably in a total amount of 1 to 15 wt.%, in particular 2 to 10 wt.%, in particular 5 to 9 wt.%.

[0037] A particularly preferred article is an aqueous sprayable hair tonic containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate preferably in a total amount of 5 to 9 wt.%.

[0038] It is also possible to use mixtures of the aforementioned optional excipients as optional excipients. If an optional excipient is used, it is further preferred if a combination of 1,2-propylene glycol and polyglyceryl-6 caprylate is used. It is particularly preferred if 1,2-propylene glycol is used in an amount of 2.0 to 20 wt% and polyglyceryl-6 caprylate in an amount of 0.3 to 9 wt%.

[0039] Another preferred article is therefore a claimed hair tonic which additionally contains at least one amine oxide as an optional excipient. The amine oxide may be at least one from the group consisting of (C5- to C18-alkyl) dimethylamine oxides or mixtures thereof. The C5- to C18-alkyl chain may, for example, be alkyl chains based on various fatty acids or fatty alcohols such as myristyl alcohol, cetyl alcohol, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, margaric acid, stearic acid, linoleic acid, oleic acid, or mixtures thereof. If an amine oxide is used as an optional excipient, this amine oxide is preferably present in a total amount of 0.2 to 5% by weight in the claimed composition. The optionally used amine oxide is particularly preferably dodecyldimethylamine oxide (INCI: Lauramine Oxide), cocamine oxide, or mixtures thereof.If dodecyldimethylamine oxide is used, it is preferably contained in a total amount of 0.2 to 10 wt.%, particularly preferably 0.5 to 5 wt.%, and especially 0.5 to 2 wt.% in the claimed composition.

[0040] A preferred object is therefore also an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and dodecyldimethylamine oxide preferably in a total amount of 0.2 to 10 wt.%, particularly preferably 0.5 to 5 wt.%, and in particular 0.5 to 2 wt.%.

[0041] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, in particular less than 0.5 wt.%, and dodecyldimethylamine oxide preferably in a total amount of 0.2 to 10 wt.%, in particular 0.5 to 5 wt.%, in particular 0.5 to 2 wt.%.

[0042] A particularly preferred object is an aqueous sprayable hair tonic containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and dodecyldimethylamine oxide preferably in a total amount of 0.5 to 2 wt.%.

[0043] Another preferred article is therefore a claimed hair tonic which additionally contains at least one betaine as an optional excipient. The betaine may preferably be one or more compounds from the group according to formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO -The composition is defined as a betaine, where R represents an alkyl chain with C5 to C21. If a betaine is used as an optional excipient, this betaine or a mixture of several betaines is preferably present in a total amount of 0.1 to 5 wt.% in the claimed composition. The optionally used betaine is particularly preferably cocamidopropyl betaine (INCI: Cocamidopropyl Betaine), which is a mixture of lauramidopropyl betaine (INCI: Lauramidopropyl Betaine), where R represents a saturated and unbranched C11 alkyl chain, and further betaines derived from coconut fatty acids with C8 to C18 alkyl chains. If cocamidopropyl betaine is used, it is preferably present in a total amount of 0.1 to 5 wt.%, particularly preferably 0.3 to 3 wt.%, and especially 0.5 to 2 wt.% in the claimed composition.

[0044] A preferred object is therefore also an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.%, adenosine in an amount of 0.05 to 3 wt.%, ethanol in an amount of a maximum of 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.% and cocamidopropyl betaine preferably in a total amount of 0.1 to 5 wt.%, particularly preferably 0.3 to 3 wt.%, in particular 0.5 to 2 wt.%.

[0045] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, in particular less than 0.5 wt.% and cocamidopropyl betaine preferably in a total amount of 0.1 to 5 wt.%, in particular 0.3 to 3 wt.%, in particular 0.5 to 2 wt.%.

[0046] A particularly preferred object is an aqueous sprayable hair tonic containing urea and optionally 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and cocamidopropyl betaine preferably in a total amount of 0.5 to 2 wt.%.

[0047] For all the embodiments described above, in which 2-hydroxyethylurea is used alone or in combination with urea, it is preferred that further excipients are included in the composition. It is particularly preferred that an amino alcohol, preferably 2-aminoethanol, and / or a lactate salt, preferably ammonium lactate, are included in an embodiment containing 2-hydroxyethylurea or in an embodiment containing 2-hydroxyethylurea and urea. In this case, it is particularly preferred if the ratio of 2-hydroxyethylurea to 2-aminoethanol is between 100:1 and 50:1. In this case, it is particularly preferred if the ratio of 2-hydroxyethylurea to ammonium lactate is between 15:1 and 25:1.

[0048] In addition to the aforementioned excipients, the claimed hair tonic may contain further ingredients such as fragrances or perfumes, extracts, in particular plant extracts, preservatives, pH adjusters, dyes, other surfactants and mixtures thereof.

[0049] It is preferred that the claimed agents have a pH value of 3.0 to 8.3 at 20°C, preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, and especially 4.2 to 5.5. All pH values ​​specified in this application apply to measurements at 20°C.

[0050] Another preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 1.0 to 20 wt.%, preferably 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.% and ethanol in an amount of 5.0 to 10 wt.%, wherein the agent has a pH of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5.

[0051] Another preferred article is therefore an aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 15 or 20 wt.%, preferably 2.0 to 7.0 wt.%, particularly 2.0 to 5.0 wt.%, adenosine in an amount of 0.05 to 3 wt.%, preferably 0.1 to 2 wt.%, particularly preferably 0.2 to 1.5 wt.%, particularly 0.5 to 1.0 wt.%, ethanol in an amount of at most 5 wt.%, preferably less than 1 wt.%, particularly preferably less than 0.5 wt.%, and at least one excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof, preferably in an amount of 0.5 to 20 wt.%, particularly preferably up to 15 wt.%, in particular up to 10 wt.%.

[0052] A further particularly preferred object is therefore an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and 1,2-propylene glycol, preferably in an amount of 5 to 10 wt.%, having a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0053] A further particularly preferred article is an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and 1,2-pentylene glycol, preferably in an amount of 1 to 3.5 wt.%, having a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0054] A further particularly preferred article is an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, a mixture of polyglyceryl-6 caprylate and polyglyceryl-4 caprate, having a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0055] A further particularly preferred article is an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.%, dodecyldimethylamine oxide preferably in a total amount of 0.5 to 2 wt.%, having a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0056] A further particularly preferred article is an aqueous sprayable hair tonic containing urea and / or 2-hydroxyethylurea in a total amount of 2.0 to 7.0 wt.%, in particular 2.0 to 5.0 wt.%, adenosine in an amount of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, ethanol in an amount of less than 0.5 wt.% and cocamidopropyl betaine preferably in a total amount of 0.5 to 2 wt.%, having a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0057] Another subject of the present application is the use of the claimed agent as a hair tonic.

[0058] Stable aqueous compositions containing adenosine in high concentrations have been shown above. A further subject matter of the present application is therefore the use of urea and / or a urea derivative for stabilizing adenosine in aqueous compositions with an ethanol content of less than 18% by weight. A further subject matter of the present application is therefore the use of urea and / or a urea derivative and an excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof, for stabilizing adenosine in aqueous compositions with an ethanol content of at most 5% by weight.

[0059] A further subject matter of the present application is therefore the use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp. A further subject matter of the present application is therefore the use of a sprayable aqueous preparation containing adenosine, urea and / or a urea derivative and an excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof, with an ethanol content of less than 18% by weight, for the cosmetic treatment of the skin, in particular the scalp.

[0060] All other characteristics of the claimed composition can also be applied to these uses.

[0061] All information provided for the described product is directly applicable to the described uses. This applies in particular, but not exclusively, to data and characteristics relating to urea (derivative), adenosine, excipients, ethanol content, viscosity, pH value, measurement methods, and other specified ingredients.

[0062] The invention is further described, but not exhaustively, by the following points: Item 1: Aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.% and adenosine in an amount of 0.05 to 3 wt.%, wherein the hair tonic contains less than 18 wt.%, preferably a maximum of 10 wt.%, in particular a maximum of 5 wt.% ethanol. Point 2: Agent according to point 1, wherein the urea derivative is 2-hydroxyethylurea. Point 3: Composition according to any of the preceding points, wherein the composition contains at least one excipient from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof. Item 4: Agents according to Item 3, wherein the diol is ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol or dipropylene glycol or mixtures thereof. Point 5: Agent according to point 3, wherein the polyethylene glycol is one or more compounds from the group according to formula HO-[CH2CH2O] x -H, where x represents an integer from 2 to 100, preferably 2 to 80, more preferably 2 to 60, and even more preferably 3 to 40 or 4 to 20. Item 6: Agent according to item 3, wherein the polymerized glycerol derivative is at least one of the polymerized glycerol derivatives known under the INCI names Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, Polyglyceryl-3 Cocoate, Polyglyceryl-6 Ricinoleate or Polyglyceryl-3 Caprate / Caprylate / Succinate, or mixtures thereof. Item 7: Agent according to item 3, wherein the amine oxide is at least one from the group of (C5- to C18-alkyl) dimethylamine oxide or mixtures thereof. Point 8: Agent according to point 3, wherein the betaine is one or more compounds from the group according to formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO - This is about, where R stands for an alkyl chain with C5 to C21. Item 9: Agent according to item 3, wherein the amino alcohol is 2-aminoethanol and / or the lactate salt is ammonium lactate. Point 10: Composition according to any of points 3 to 9, wherein the composition contains a maximum of 5 wt.%, preferably less than 1 wt.% ethanol, and in particular is free of ethanol. Item 11: Agents according to any of the preceding items, wherein the agent contains less than 0.5% by weight of one or more ingredients from the adenosine 5'-phosphate group. Item 12: Agent according to any of the preceding items, wherein the agent contains 0.1 to 2.0 wt.%, preferably 0.1 to 1.0 wt.% adenosine. Item 13: Agent according to any of the preceding items, wherein the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 7.0 wt.%, more preferably 2.0 to 5.0 wt.%. Point 14: Agent according to any of points 3 to 13, wherein the auxiliary substance(s) is contained in a total amount of 0.5 to 35 wt.%, preferably in an amount up to 25 wt.%. Item 15: Agent according to any of the preceding items, wherein the agent has a viscosity of at most 150 mPa*s, particularly preferably of 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s as measured by Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM). Point 16: Agent according to any of the preceding points, wherein the agent has a pH of 3.0 to 8.3 at 20°C, preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, especially 4.2 to 5.5. Item 17: Use of urea and / or urea derivative for stabilizing adenosine in aqueous compositions with an ethanol content of less than 18 wt.%. Item 18: Use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, especially the scalp. Examples of implementation:

[0063] The compositions E1 to E13 were produced as follows: Adenosine was dissolved in water at 50 °C. Optionally, a preservative such as sodium benzoate was dissolved in the 50 °C solution. Optionally, ethanol was then added. All other ingredients except urea and / or urea derivatives were added and dissolved. The solution was then cooled to below 25 °C. At a temperature between 20 and 25 °C, urea and / or urea derivatives were added and dissolved in the solution.

[0064] Compositions V1 to V6 were prepared as previously described. Table 1 E1 E2 E3 E4 E5 E6 E7 Adenosine 0,75 0,75 0,75 0,75 0,75 0,75 0,75 Ethanol 5 10 5 10 5 10 urea 5 5 Hydrovance 1 10 5 5 10 10 Water add 100 add 100 add 100 add 100 add 100 add 100 add 100 pH (20 °C) 6,2 6,2 6,1 8,0 7,9 8,1 8,1 Stability 21 days at 0°C / RT / 40°C + / + / + + / + / + + / + / + + / + / + + / + / + + / + / + + / + / + Table 2 E8 E9 E10 E11 E12 E13 Adenosine 0,75 0,75 0,75 0,75 0,75 0,75 Ethanol urea 5 5 5 5 5 5 Hydrovance 1 Propylene glycol 10 5 Pentylene glycol 2 Tegosolve 90 MB 2 7 Empigen Mayor 3 1 Cocamidopropyl betaine 1 Water add 100 add 100 add 100 add 100 add 100 add 100 pH (20 °C) 4,7 5,4 5,6 5,3 7,2 5,9 Stability 21 days at 0°C / RT / 40°C + / + / + + / + / + + / + / + + / + / + + / + / + + / + / + Table 3 V1 V2 V3 V4 V5 V6 Adenosine 0,75 0,75 0,75 0,75 0,75 0,75 Ethanol 5 10 20 urea 5 10 Water add 100 add 100 add 100 add 100 add 100 add 100 pH (20 °C) 6,9 6,6 6,3 6,2 6,0 5,9 Stability 21 days at 0°C / RT / 40°C n / n / n n / n / n n / n / n n / n / + n / + / + n / n / + 1 INCI: Hydroxyethyl Urea (Hydrovance: Preparation of Hydroxyethyl Urea) 2 : INCI: Polyglyceryl-6 Caprylate (and) Polyglyceryl-4 Caprate 3 : INCI: Lauramine Oxide

[0065] The pH values ​​of the compositions were determined immediately after preparation. The resulting compositions were stored at 0°C, at room temperature (20°C), and at 40°C ("+": stable; "n": not stable). Visual inspection showed that all compositions E1-E13 were stable for at least three weeks at all tested temperatures. The comparison compositions V1-V6 were not stable for this period or only under a few conditions, where a precipitate formed.

Claims

[1] Aqueous sprayable hair tonic containing urea and / or a urea derivative in a total amount of 1.0 to 20 wt.% and adenosine in an amount of 0.05 to 3 wt.%, characterized by that the hair tonic contains less than 18% by weight, preferably a maximum of 10% by weight, in particular a maximum of 5% by weight of ethanol. [2] Agent according to claim 1, wherein the urea derivative is 2-hydroxyethylurea and / or the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 7.0 wt.%, more preferably 2.0 to 5.0 wt.%. [3] Agent according to one of the preceding claims, wherein the agent contains at least one excipient from the group of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols and lactate salts or mixtures thereof. [4] The agent according to claim 3, wherein the diol is ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol or dipropylene glycol or mixtures thereof. [5] Agent according to claim 3, wherein the polymerized polymerized glycerin derivative is at least one of the polymerized glycerin derivatives known under the INCI names Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, Polyglyceryl-3 Cocoate, Polyglyceryl-6 Ricinoleate or Polyglyceryl-3 Caprate / Caprylate / Succinate or mixtures thereof. [6] Agent according to one of claims 3 to 5, wherein the agent contains a maximum of 5% by weight, preferably less than 1% by weight, of ethanol, in particular is free of ethanol. [7] Agent according to one of the preceding claims, wherein the agent comprises 0.1 to 2.0 wt.%, preferably 0.1 to 1.0 wt.% adenosine. [8] Agent according to one of the preceding claims, wherein the agent has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM). [9] A composition according to any one of the preceding claims, wherein the composition has a pH of 3.0 to 7.0 at 20°C. [10] Use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular scalp.