Sulfated archaeosomes as mucosal vaccine adjuvants

Sulfated glycoarchaeol archaeosomes address the need for effective mucosal adjuvants by enhancing immune responses without multivalent cations, offering a practical and efficient solution for mucosal vaccine formulations.

GB2702692APending Publication Date: 2026-06-24NAT RES COUNCIL OF CANADA
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Patent Information

Application Number
GB2024017581
Authority / Receiving Office
GB · GB
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-11-29
Publication Date
2026-06-24

AI Technical Summary

Technical Problem

Current vaccines lack effective mucosal adjuvants that can induce strong and prolonged mucosal immunity without the use of multivalent cations or other adjuvants, leading to suboptimal protection against mucosal infections and the need for repeated booster doses.

Method used

Sulfated glycoarchaeol archaeosomes are used as mucosal adjuvants, formulated without multivalent cations or TLR agonists, to enhance antigen-specific mucosal and systemic immune responses when administered mucosally.

Benefits of technology

Sulfated glycoarchaeol archaeosomes effectively elicit antigen-specific mucosal and systemic immune responses, including IgA antibody and cellular responses, without the manufacturing complexities of AMVAD formulations, providing a practical and commercially viable mucosal adjuvant solution.

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Abstract

Provided is an adjuvant for mucosal vaccines comprising a sulfated archaeosome comprising a sulfated glycoarchaeol. The glycoarchaeol may be present as a pharmaceutically acceptable salt. The adjuvant
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Citation Information

Patent Citations

  • Adjuvant comprising a glycoarchaeol and an immunostimulant

    WO2022149074A1

  • Mixture of stereoisomers of a sulfated glycolipid

    WO2023131849A1