Vitamin d pediatric dosage forms, and methods of making and using the same
By using water-insoluble polymers such as Eudragit or ethylcellulose as substrates, multiple vitamin D sustained-release dosage forms were prepared, which solved the problem that existing instant-release dosage forms were difficult to meet long-term stable release, and achieved long-term sustained-release and high bioavailability of vitamin D.
Patent Information
- Application Number
- JP2024214269
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2018-08-31
- Filing Date
- 2024-12-09
- Publication Date
- 2025-04-10
AI Technical Summary
The dosage forms of existing vitamin D compounds are mostly in immediate release forms, which are difficult to meet the needs of long-term and stable release, especially in the pediatric patient population, and it is difficult to develop suitable oral sustained-release dosage forms.
Water-insoluble polymers such as Eudragit or ethylcellulose are used as substrates to achieve sustained release of vitamin D compounds through diffusion and erosion mechanisms, and various forms of sustained release agents are prepared, such as spherical particles, nano/microparticle particles, etc.
The long-term and stable release of vitamin D compounds is achieved, suitable for children and adult patients, improving the bioavailability and therapeutic effect of the drug, while reducing the dose frequency.