Etofenprox-containing animal pest control agent

Abstract

To provide an animal pest control agent, in particular, an animal pest control agent that is suitable for direct application to animals.SOLUTION: An animal pest control agent is prepared that contains: etofenprox in an amount of 20 mass% or more and less than 50 mass%; and ethylene glycol ether and / or medium-chain fatty acid triglyceride. The animal pest control agent may further contain an antioxidant.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an agent for controlling pests attached to animals such as pets and livestock. More specifically, the present invention relates to a pest control agent for animals for controlling pests such as fleas, mites, or lice.

Background Art

[0002] Pests attached to animals that have contact with humans, such as pets or livestock, can transmit diseases that cause serious symptoms in these animals, or can cause allergies or harmful effects on humans. For these pests, pest control agents for dropping, spraying, or applying to the body surface of pets and livestock are known.

[0003] As active ingredients of such pest control agents for animals, combinations of pyrethroid compounds or pyrethroid compounds and other compounds are widely used (Patent Document 1).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] There is a need for a further pest control agent for animals that has good stability and can surely control pests.

[0006] The present invention aims to provide a pest control agent for animals that can be directly applied to animals targeted for pest control and has a control effect.

Means for Solving the Problems

[0007] As a result of intensive studies to solve this problem, the present inventors have found that an animal pest control agent that is stable even at low temperatures can be prepared by using etofenprox at a specific concentration as an active ingredient and further containing ethylene glycol ethers and / or medium-chain fatty acid triglycerides, and have completed the present invention. That is, the present invention provides an animal pest control agent as described below. Item 1. An animal pest control agent containing 20 w / v% or more and less than 50 w / v% of etofenprox; and

[0008] ethylene glycol ethers and / or medium-chain fatty acid triglycerides. Item 2. The animal pest control agent according to Item 1, wherein the ethylene glycol ethers are diethylene glycol monoethyl ether. Item 3. The animal pest control agent according to Item 1 or 2, further containing an antioxidant. Item 4. The animal pest repellent according to any one of Items 1 to 3, wherein the pest is a flea or a mite. Item 5. The animal pest repellent according to any one of Items 1 to 4, containing 0.3 parts by mass or more and 4 parts by mass or less of the ethylene glycol ethers and / or medium-chain fatty acid triglycerides with respect to 1 part by mass of the etofenprox. Furthermore, the present invention provides a stabilization method as described below. Item 6. In a composition containing etofenprox, the concentration of the etofenprox is set to 20 w / v% or more and less than 50 w / v%, and further ethylene glycol ethers and / or

[0009]

[0009] medium-chain fatty acid triglycerides are contained. Item 6. In a composition containing etofenprox, the concentration of the etofenprox is set to 20 w / v% or more and less than 50 w / v%, and further ethylene glycol ethers and / or medium-chain fatty acid triglycerides are contained. A method for stabilizing the composition by coexisting medium-chain fatty acid triglycerides.

Advantages of the Invention

[0010] The present invention can provide an excellent animal pest control agent with good stability.

Modes for Carrying Out the Invention

[0011] In this specification, the unit of content "w / v%" is synonymous with "g / 100 ml".

[0012] [Animal pest control agent] The animal pest control agent of the present invention is an animal pest control agent containing etofenprox as an active ingredient. agent for controlling pests for animals.

[0013] (Active ingredient) When referred to as an active ingredient in this specification, it has the same meaning as the ingredient that exhibits the efficacy of pest control.

[0014] Here, etofenprox means 2-(4-ethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether. ether. Any active stereoisomer or mixture can be used as etofenprox. can be used.

[0015] In the animal pest control agent of the present invention, the content of etofenprox with respect to the total amount of the animal pest control agent is 20 w / v% or more and less than 50 w / v%, preferably 25 w / v% or more and 48 w / v% or less, more preferably 30 w / v% or more and 45 w / v% or less, even more preferably 35 w / v% or more and 42 w / v% or less, and particularly preferably 40 w / v%. / v% or less, more preferably 30 w / v% or more and 45 w / v% or less, even more preferably 35 w / / v% or less, and particularly preferably 40 w / v%. v% or more and 42 w / v% or less, and even more preferably 40 w / v%.

[0016] (Ethylene glycol ethers) In addition to etofenprox, the animal pest control agent of the present invention may contain ethylene glycol ethers. By using ethylene glycol ethers, after dropping the pest control agent containing etofenprox on the animal, the drug spreads over the entire body surface along the sebum on the skin surface of the animal. Here, the ethylene glycol ethers are not particularly limited as long as they are of a grade used as a component of a skin external preparation for animals or humans. Examples of the ethylene glycol ethers include diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, diethylene glycol monoisobutyl ether, diethylene glycol dimethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, triethylene glycol monobutyl ether, tetraethylene glycol monobutyl ether, and the like. Among these, diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, diethylene glycol monopropyl ether, ethylene glycol monobutyl ether, triethylene glycol monobutyl ether, and tetraethylene glycol monobutyl ether are preferable, and diethylene glycol monoethyl ether is particularly preferable.

[0017] From the viewpoint of exerting the effects of the present invention, the content of ethylene glycol ethers in the total amount of the animal pest control agent of the present invention is preferably 10 w / v% or more and 80 w / v% or less, more preferably 20 w / v% or more and 75 w / v% or less, and still more preferably 30 w / v% or more and 70 w / v% or less. ​It is more preferable that the content is 50 w / v % or more and 65 w / v % or less, and even more preferable that the content is 50 w / v % or more and 65 w / v % or less.

[0018] In particular, the amount of diethylene glycol monoethyl ether based on the total amount of the animal pest control agent of the present invention is In order to exert the effects of the present invention, the content of terephthalate is 10 w / v% or more and 80 w / v% or less. is preferable, and 20 w / v% or more and 75 w / v% or less is more preferable, and 30 w / v% or more and 70 w / v% or less is more preferable, and 50 w / v% to 65 w / v% is even more preferable. stomach.

[0019] In the animal pest control agent of the present invention, the ethylene glycol The ratio of diethyl ethers is 0.3 parts by mass or more per part by mass of etofenprox. The amount is preferably 0.5 parts by mass or less and 3 parts by mass or less, more preferably 1 part by mass or more and 2 parts by mass or less. Parts by weight or less is more preferable, and 1.2 parts by weight or more and 1.8 parts by weight or less is even more preferable.

[0020] (Medium chain triglyceride) The animal pest control agent of the present invention contains, in addition to etofenprox, a medium-chain fatty acid triglyceride. The use of medium chain triglycerides can reduce the amount of etofenpro After dropping the insecticide containing licorice on the animal, the drug is distributed over the entire body surface through the sebum on the surface of the animal's skin. Here, the medium-chain fatty acid triglyceride is a component of an external skin preparation for animals or humans. There is no particular limitation as long as the grade is suitable for use as a food additive. The glyceride is a fatty acid triglyceride having 6 to 10 carbon atoms, and more specifically, It is obtained by reacting 6-10 unsaturated fatty acids with glycerin, and the molar ratio of unsaturated fatty acids and glycerin is The ratio of fatty acids in the medium chain triglycerides is 3:1. Glyceryl tri(caprylic acid·capric acid), glyceryl tricaprylate, tricapric acid glyceryl, etc. are preferred. As the medium-chain fatty acid triglyceride, it is possible to use a compound extracted from plants or the like, or it is also possible to use a compound synthesized by chemical means.

[0021] From the viewpoint of exerting the effects of the present invention, the content of the medium-chain fatty acid triglyceride in the total amount of the animal pest control agent of the present invention is preferably 10 w / v% or more and 80 w / v% or less, more preferably 20 w / v% or more and 75 w / v% or less, still more preferably 30 w / v% or more and 70 w / v% or less, and even more preferably 50 w / v% or more and 65 w / v% or less.

[0022] In the animal pest control agent of the present invention, the ratio of the medium-chain fatty acid triglyceride to etofenprox is preferably 0.3 parts by mass or more and 4 parts by mass or less, more preferably 0.5 parts by mass or more and 3 parts by mass or less, still more preferably 1 part by mass or more and 2 parts by mass or less, and even more preferably 1.2 parts by mass or more and 1.8 parts by mass or less, with respect to 1 part by mass of etofenprox.

[0023] (Antioxidant) The animal pest control agent of the present invention may contain an antioxidant in addition to etofenprox and ethylene glycol ethers and / or medium-chain fatty acid triglycerides. Examples of the antioxidant used in the present invention include dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), 4,4'-thiobis(3-methyl-6-t-butylphenol) (TBMTBP), etc. Among these, BHT is particularly preferred.

[0024] The content of the antioxidant in the total amount of the animal pest control agent of the present invention is 0.001 w / v% or more and 10.0 w / v% or less is preferable, 0.003 w / v% or more and 5.0 w / v% or less is more preferable, 0.005 w / v% or more and 1.5 w / v% or less is even more preferable, 0.01 w / v% or more and 1.0 w / v% or less is even more preferable.

[0025] In the animal pest control agent of the present invention, the ratio of the antioxidant to etofenprox is preferably 0.00003 part by mass or more and 3 parts by mass or less of the antioxidant with respect to 1 part by mass of etofenprox, more preferably 0.000005 part by mass or more and 1.5 parts by mass or less, even more preferably 0 .000008 part by mass or more and 1.0 part by mass or less, and even more preferably 0.00001 part by mass or more and 0.8 part by mass or less.

[0026] In the animal pest control agent of the present invention, the ratio of the antioxidant to ethylene glycol ethers and / or medium-chain fatty acid triglycerides is 0.000001 part by mass or more and 3.0 parts by mass or less of the antioxidant with respect to 1 part by mass of ethylene glycol ethers and / or medium-chain fatty acid triglycerides, preferably 0.000005 part by mass or more and 2.0 parts by mass or less, more preferably 0.000008 part by mass or more and 1.0 part by mass or less, and even more preferably 0.00 001 part by mass or more and 0.5 part by mass or less.

[0027] (Water) The animal pest control agent of the present invention can be formulated with water, or can be in the form of a composition that does not contain any water at all. Such water includes purified water such as ion-exchanged water, and ordinary water such as tap water or industrial water. ​​​​​The water content with respect to the total amount of the animal pest control agent is preferably 5 w / v% or less, more preferably 3 w / v % or less, and particularly preferably it contains no water or substantially no water.

[0028] (Pest) As used herein, pests include, but are not limited to, in particular, fleas (including fleas parasitic on dogs, cats, etc.), ticks (including ticks such as ixodid ticks, trombiculid mites, sasara mites, hizenda mites, and kemono tsume mites, etc.), or parasitic or blood-sucking pests such as lice, mosquitoes, etc. Particularly preferred pests to be controlled are fleas, ticks or lice.

[0029] The animals of the present invention include various animals such as various pets, livestock, and poultry. In particular, pets such as dogs, cats, rabbits, hamsters, etc., and livestock and poultry such as cows, horses, pigs, chickens, etc.

[0030] (pH) From the viewpoints of component stability or safety, etc., the animal pest control agent of the present invention preferably has a liquid property with a pH of 3 to 10. More preferably, it is an animal pest control agent with a pH of 4 to 8. The pH of the animal pest control agent can be measured at 20°C using a commercially available pH meter (for example, manufactured by HORIBA, Ltd., F-52 (registered trademark) type, etc.). When the animal pest control agent does not contain water, the value measured after diluting the animal pest control agent 20-fold with purified water is taken as the pH.

[0031] (Viscosity) From the viewpoints of component stability, etc., the animal pest control agent of the present invention preferably has a viscosity at 25°C, SPINDL E No. M1, 100 rpm of preferably about 0.5 to 1000 mPa·s more preferably about 3 to 100 mPa·s. The viscosity of the animal pest control agent At 25°C, it can be measured using a commercially available viscometer (for example, TVB-10M type manufactured by Toki Sangyo Co., Ltd.). It can be determined.

[0032] (Other components) As long as the effects of the present invention are not inhibited, the animal pest control agent of the present invention may appropriately contain optional components other than etofenprox. For example, the optional components include other pest control components other than etofenprox, pH adjusters, surfactants, silicone compounds, chelating agents, recontamination preventers, polymers, preservatives, antibacterial agents, fungicides, natural product extracts, dispersants, antioxidants, thickeners, thinning agents, stabilizers, deodorants, fragrances, pigments, and the like. As an example, the optional components may include other pest control components other than etofenprox, pH adjusters, surfactants, silicone compounds, chelating agents, recontamination preventers, polymers, preservatives, antibacterial agents, fungicides, natural product extracts, dispersants, antioxidants, thickeners, thinning agents, stabilizers, deodorants, fragrances, pigments, and the like. Examples of the pH adjuster include, but are not limited to, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, ammonia, potassium hydroxide, sodium hydroxide, and the like. Examples of the pH adjuster include, but are not limited to, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, ammonia, potassium hydroxide, sodium hydroxide, and the like. Examples of the pH adjuster include, but are not limited to, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, ammonia, potassium hydroxide, sodium hydroxide, and the like.

[0033] Examples of the pH adjuster include, but are not limited to, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, ammonia, potassium hydroxide, sodium hydroxide, and the like. Examples of the pH adjuster include, but are not limited to, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, ammonia, potassium hydroxide, sodium hydroxide, and the like. Examples of the pH adjuster include, but are not limited to, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, ammonia, potassium hydroxide, sodium hydroxide, and the like.

[0034] (Surfactant) Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid alkyl ester, polyoxyethylene alkylamine, alkyl polyglucoside, polyoxyethylene hydrogenated castor oil, and the like. Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid alkyl ester, polyoxyethylene alkylamine, alkyl polyglucoside, polyoxyethylene hydrogenated castor oil, and the like. Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid alkyl ester, polyoxyethylene alkylamine, alkyl polyglucoside, polyoxyethylene hydrogenated castor oil, and the like.

[0035] (Uses, etc.) The animal pest control agent of the present invention can be applied, for example, by dripping it on the back or the like of an animal, although not limited thereto. It can be applied in the form of dripping on the back or the like of an animal, although not limited thereto.

[0036] The animal pest control agent of the present invention can be used once a week, once every two weeks, once a month, once every three months, or once every six months, depending on the use and the like. It can be used once a week, once every two weeks, once a month, once every three months, or once every six months, depending on the use and the like.

[0037] The amount of the control agent of the present invention, from the viewpoint of the control effect, for example, per application, the amount of etofenprox is preferably 100 mg or more, more preferably 200 mg or more , and even more preferably 300 mg or more. The amount of the control agent of the present invention, from the viewpoint of safety , per application, the amount of etofenprox is preferably 5000 mg or less , more preferably 3000 mg or less, and even more preferably 2000 mg or less .

[0038] [Stabilization method] The present invention also relates to a method for stabilizing a composition by blending etofenprox with ethylene glycol ethers and / or medium-chain fatty acid triglycerides in the composition. Here, stabilization means that, particularly at room temperature and in the temperature range from around -5°C to room temperature, no precipitation of etofenprox is observed even after storage for 24 hours or more. In the stabilization method of the present invention, for etofenprox and its content, it conforms to the content described in the above-mentioned animal pest control agent. Also, for pH, other optional components and their content and other conditions, it conforms to the content described in the above-mentioned animal pest control agent.

Examples

[0039] Next, the present invention will be specifically described by way of examples, but the present invention is not limited to the following examples. In addition, the unit of the amount of each component in the table is w / v% unless otherwise specified in the table.

[0040] [1] Stability test The compositions shown in Table 1 were prepared by a conventional method, and the stability of these compositions was evaluated.

[0041] For the stability evaluation, specifically, after transferring each composition into a 20 mL screw tube, it was sealed and left standing under the condition of -5°C. After 24 hours, the sample was taken out from the -5°C storage to room temperature and the state of the solution at that time was visually observed. Those with crystal precipitation were marked as ×, and those without were marked as 〇 for evaluation.

[0042] The results are shown in Table 1.

[0043]

Table 1

[0044] As a result of the stability test, among the compositions of the examples, significant stability was shown at -5°C compared with the compositions of the comparative examples. ​

Claims

[Claim 1] The invention described in the specification.

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