Particles containing lipid matrix core and active ingredient

A lipid matrix core with dispersed active ingredients and optional coatings addresses the challenge of incorporating lipid-soluble compounds in multiparticulates, enhancing stability and efficacy in oral dosage forms.

JP2025160349APending Publication Date: 2025-10-22LONZA SALES AG
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Patent Information

Application Number
JP2025125709
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2019-12-10
Filing Date
2025-07-28
Publication Date
2025-10-22

AI Technical Summary

Technical Problem

Existing technologies face difficulties in incorporating therapeutically effective amounts of lipid-soluble active ingredients, such as fat-soluble vitamins and cannabinoids, into multiparticulate materials due to processing challenges that reduce efficacy and cause stability issues.

Method used

A composition comprising particles with a lipid matrix core containing a dispersed active ingredient, optionally coated with additional layers, which are then incorporated into oral dosage forms to stabilize and protect the active ingredients.

Benefits of technology

The solution provides stable and effective delivery of lipid-soluble active ingredients, addressing efficacy and stability concerns by protecting the ingredients from degradation and ensuring uniform distribution in oral dosage forms.

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Abstract

To provide a composition having a multiparticulate material capable of sufficiently incorporating a therapeutically effective amount of a fat-soluble active ingredient, having suitable efficacy and storage stability.SOLUTION: A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.SELECTED DRAWING: None
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