Nattokinase activity preservation chemical storage device

Abstract

In the field of medical supplies and food / drug storage technology, we provide a drug storage device for maintaining nattokinase activity. The solution includes a box body 1 and a screw-fitted box cover 2. The box body contains a main box 11 for storing capsules and a micro-perforated desiccant inner tray chamber 12, which physically isolates the capsules and keeps them fresh. The key feature is the activity detection module 21 integrated into the box cover. This module is equipped with a dedicated capsule detection chamber, and uses a built-in needle sampling mechanism to drip the capsule contents onto a specific colorimetric substrate test strip at the bottom. An optical sensor reads the RGB values ​​of the color reaction, and after processing by an MCU controller, the activity results are output via a display mechanism. This device integrates in situ, rapid, quantitative detection of nattokinase capsule activity with intelligent storage, providing simple operation and intuitive, reliable results. It solves the problems of conventional technology, which make it difficult to easily quantitatively detect nattokinase capsule activity and which are susceptible to moisture inactivation during storage.

Description

[Technical Field]

[0001] The present application relates to the field of medical supplies and food / drug storage technology, and in particular to a drug storage device for preserving nattokinase activity. [Background technology]

[0002] As a protease, nattokinase's biological activity is easily affected by environmental temperature and humidity, and it is prone to absorbing moisture during storage, causing it to deteriorate and become inactive. Nattokinase is also prone to deterioration when stored in capsules. Conventional health food and medicine storage boxes are usually made of plastic or metal and contain multiple compartments, with functions limited to individual storage of medicines and light-shielding storage. Some high-end medicine boxes are integrated with electronic modules with simple medication reminder functions and desiccant chambers. However, such conventional technologies have the following drawbacks:

[0003] Functional monotony: Only physical storage, no ability to monitor the quality of stored items. Missing information: Users have no idea whether the nattokinase in the capsules may be inactivated by improper or too long storage, potentially resulting in an ineffective product. Easy to be contaminated: Usually, the bottle contains a paper tray or cotton mat, plus a small silica gel desiccant bag, which is easily damaged, causing dust contamination, and the environment inside the bottle cannot be controlled after opening. Summary of the Invention [Problem to be solved by the invention]

[0004] In view of the above, the main objective of the present application is to solve one of the above problems. [Means for solving the problem]

[0005] First, the present application provides a chemical storage device for preserving nattokinase activity, comprising a box body and a box cover screwed to the box body, wherein a main chamber for storing nattokinase capsules is provided in the box body, a desiccant inner tray chamber is provided in the main chamber, a desiccant is placed in the desiccant inner tray chamber, an activity detection module is provided on the top right of the box cover, a display mechanism is provided on the top left of the box cover, a gasket is provided on a surface where the box cover contacts the box body, and a battery case is provided on a side of the box cover, wherein the activity detection module comprises a cover plate and a dedicated detection cover. The detection-only capsule chamber includes a capsule chamber, a detection unit, a sampling mechanism, a fixing mechanism, a signal reading unit, and a control button, the detection-only capsule chamber is disposed inside the box cover, the cover plate is connected to the top of the box cover via a rotating shaft and covers the detection-only capsule chamber, the detection unit is disposed at the bottom of the detection-only capsule chamber, the sampling mechanism is disposed at the bottom of the detection-only capsule chamber, the fixing mechanism is disposed on a side of the detection-only capsule chamber, the signal reading unit is disposed at the bottom of the cover plate, and the control button is disposed at the top of the box cover.

[0006] Furthermore, the present application provides a chemical storage device for preserving nattokinase activity, comprising: placing a nattokinase capsule into the detection-only capsule chamber; starting a detection program with the control button; fixing the capsule in the detection-only capsule chamber with the fixing mechanism; piercing the capsule with the sampling mechanism to drop its contents onto the detection unit; obtaining an optical signal generated by the action of the contents through the signal reading unit; processing the optical signal to obtain a nattokinase activity result; and outputting the activity result through the display mechanism. [Effects of the Invention]

[0007] The beneficial effects of the present application are as follows: 1. Integration of activity detection and storage: The biological activity detection function is integrated into the medicine box cover, allowing nattokinase activity to be detected without any additional equipment. 2. Rapid detection, visualization, and quantification: By combining a specific chromogenic substrate with an optical sensor, enzyme activity can be converted into a quantifiable color signal, and the results can be displayed to the user on a display or indicator. 3. Easy and safe operation: The automated design of the machine allows users to simply insert a capsule and press a button to automatically complete the entire process of sampling, reaction and detection, avoiding users from directly touching the sample. 4. Providing excellent freshness-retaining storage conditions: By installing an independent desiccant inner tray chamber and utilizing the micro-hole design on its wall, a dry environment for the medicine is maintained and the desiccant and medicine are physically isolated. [Brief explanation of the drawings]

[0008] [Figure 1] FIG. 1 is an image diagram of the chemical storage device for preserving nattokinase activity described in the present application. [Figure 2] FIG. 2 is an enlarged view of part A of FIG. [Figure 3] FIG. 3 is a flow chart of the chemical storage device for preserving nattokinase activity described in the present application. DETAILED DESCRIPTION OF THE INVENTION

[0009] The present application will be described in more detail below with reference to the drawings and examples. It should be understood that the specific examples described herein are only for the purpose of illustrating the relevant application and are not intended to limit the same. For ease of explanation, only parts relevant to the present invention are shown in the drawings. Furthermore, unless conflicting, the embodiments and features of the embodiments in the present application can be combined with each other.

[0010] As shown in Figures 1 and 2, the device for storing chemicals for preserving nattokinase activity comprises a box body 1 and a box cover 2 that is screwed onto the box body 1. A main chamber 11 for storing nattokinase capsules is provided in the box body 1, and a desiccant inner tray chamber 12 is provided in the main chamber 11, and a desiccant is placed in the desiccant inner tray chamber 12. An activity detection module 21 is provided on the top right side of the box cover 2, a display mechanism 22 is provided on the top left side of the box cover 2, a gasket 23 is provided on the surface where the box cover 2 comes into contact with the box body 1, and a battery case 24 is provided on the side of the box cover 2.

[0011] Preferably, the material of the box body 1 and the box cover 2 is black or dark, opaque ABS resin.

[0012] Here, the active detection module 21 includes a cover plate 211, a detection capsule chamber 212, a detection unit 213, a sampling mechanism 214, a fixing mechanism 215, a signal reading unit 216, and a control button 217, wherein the detection capsule chamber 212 is disposed inside the box cover 2, the cover plate 211 is connected to the top of the box cover 2 via a rotating shaft and covers the detection capsule chamber 212, the detection unit 213 is disposed at the bottom of the detection capsule chamber 212, the sampling mechanism 214 is disposed at the bottom of the detection capsule chamber 212, the fixing mechanism 215 is disposed on the side of the detection capsule chamber 212, the signal reading unit 216 is disposed at the bottom of the cover plate 211, and the control button 217 is disposed at the top of the box cover 2. Preferably, the sampling mechanism 214 includes a puncture needle 2141 and a first telescopic rod 2142, one end of the first telescopic rod 2142 is connected to the inside of the box cover 2, and the other end of the first telescopic rod 2142 is connected to the puncture needle 2141, the first telescopic rod 2142 drives the up and down movement of the puncture needle 2141, and the puncture needle 2141 is installed at the bottom of the detection-only capsule chamber 212. The first telescopic rod 2142 is driven by a micro linear stepping motor. The puncture needle 2141 is made of medical-grade stainless steel.

[0013] Preferably, the fixing mechanism 215 includes a first holding plate 2151 and a second telescopic rod 2152, one end of the second telescopic rod 2152 is connected to the inside of the box cover 2, the other end of the second telescopic rod 2152 is connected to the first holding plate 2151, the second telescopic rod 2152 drives the left and right movement of the first holding plate 2151, and the first holding plate 2151 is installed on the right side inside the detection-only capsule chamber 212.

[0014] Preferably, the fixing mechanism 215 further includes a second holding plate 2153 and a third telescopic rod 2154, one end of the third telescopic rod 2154 is connected to the inside of the box cover 2, the other end of the third telescopic rod 2154 is connected to the second holding plate 2153, the third telescopic rod 2154 drives the left and right movement of the second holding plate 2153, and the second holding plate 2153 is installed on the left side inside the detection-only capsule chamber 212. In the fixing mechanism 215, the second telescopic rod 2152 and the third telescopic rod 2154 are also driven by micro linear motors. To prevent the capsule from being pinched and broken, the contact surfaces of the first pressing plate 2151 and the second pressing plate 2153 are covered with a flexible silicone rubber layer.

[0015] Preferably, the detection unit 213 is a chromogenic substrate test strip card that can be specifically decomposed by nattokinase, and the test strip card can be replaced periodically.

[0016] Preferably, the signal reading unit 215 includes an optical sensor and an MCU controller. The optical sensor includes a white LED light source and an RGB color sensor. The sensor is located at the bottom of the cover plate 211, facing the test strip card reaction zone below the detection chamber. The MCU controller controls the entire detection process.

[0017] In one preferred embodiment, the wall of the desiccant inner tray chamber 12 is perforated with micro-holes, allowing moisture exchange between the desiccant and the main chamber 11 while still physically isolating them.

[0018] The actual operation process for detecting capsule activity is as follows: The user opens the cover plate 211 of the activity detection module 21, places a capsule in the dedicated capsule chamber 212, and then closes the cover plate 211. The control button 217 is pressed to start the detection program. The system first uses the second telescopic rod 2152 and the third telescopic rod 2154 to drive the first retaining plate 2151 and the second retaining plate 2153 to secure the capsule in the dedicated capsule chamber 212. The first telescopic rod 2142 moves the puncturing needle 2141 upward, piercing the capsule, and the contents of the capsule fall onto the test strip card in the detection unit 213 at the bottom of the chamber. The color of the test strip card changes. The RGB color sensor integrated in the signal reading unit 216 scans the color-producing area of ​​the test strip card and transmits the scanned data to the MCU controller. The MCU controller then uses a pre-stored activity determination threshold algorithm to determine the activity and outputs the result to the display mechanism 22. If the display mechanism 22 is an LED indicator, it can inform the user of the result by green, red or flashing. If it is an LCD display, it can directly display information such as letters, digital or percentage.

[0019] FIG. 3 shows a flow chart of the chemical storage device for preserving nattokinase activity of the present application. In one embodiment, the flow chart of the nattokinase activity preserving chemical storage device is as follows: placing a nattokinase capsule in the detection-only capsule chamber; initiating a detection program via said control button; Fixing the capsule in the detection-only capsule chamber by the fixing mechanism; puncturing the capsule with the sampling mechanism and causing its contents to fall onto the detection unit; The detection unit acquires an optical signal generated by the action of the contents through the signal reading unit; processing the optical signal to obtain a nattokinase activity result; outputting the activity results by the display mechanism; Includes.

[0020] The above has described the basic principles, main features and advantages of the present application. Those skilled in the art will understand that the present application is not limited to the above examples, and that the above examples and description only illustrate the principles of the present application. Various changes and modifications may be made to the present application without departing from the spirit and scope of the present application, and these changes and modifications are also within the scope of the application for which protection is sought. The scope of protection sought for the present application is defined by the appended utility model claims and their equivalents. [Explanation of symbols]

[0021] 1 box body 11 Main Box 12 Desiccant inner tray chamber 2 box covers 21 Liveness Detection Module 211 Cover Plate 212 Capsule chamber for detection only 213 Detection Unit 214 Sampling Mechanism 2141 Puncture needle 2142 First Telescopic Rod 215 Fixing mechanism 2151 First pressure plate 2152 Second Telescopic Rod 2153 Second pressure plate 2154 Third Telescopic Rod 216 Signal Reading Unit 217 Control Button 22 Display mechanism 23 Gasket 24 Battery case

Claims

1. The box includes a box body 1 and a box cover 2 that is screwed onto the box body 1. A main chamber 11 for storing nattokinase capsules is provided in the box body 1, and a desiccant inner tray chamber 12 is provided in the main chamber 11, and a desiccant is placed in the desiccant inner tray chamber 12. An activity detection module 21 is provided on the top right side of the box cover 2, a display mechanism 22 is provided on the top left side of the box cover 2, a gasket 23 is provided on the surface where the box cover 2 contacts the box body 1, and a battery case 24 is provided on the side of the box cover 2, the activity detection module (21) includes a cover plate (211), a detection capsule chamber (212), a detection unit (213), a sampling mechanism (214), a fixing mechanism (215), a signal reading unit (216), and a control button (217); the detection capsule chamber (212) is installed inside the box cover (2); the cover plate (211) is connected to the top of the box cover (2) via a rotating shaft and covers the detection capsule chamber (212); the detection unit (213) is installed at the bottom of the detection capsule chamber (212); the sampling mechanism (214) is installed at the bottom of the detection capsule chamber (212); the fixing mechanism (215) is installed on the side of the detection capsule chamber (212); the signal reading unit (216) is installed at the bottom of the cover plate (211); and the control button (217) is installed at the top of the box cover (2).

2. The sampling mechanism 214 includes a puncture needle 2141 and a first telescopic rod 2142.

2. The device for storing a chemical for preserving nattokinase activity according to claim 1, wherein one end of the first telescopic rod 2142 is connected to the inside of the box cover 2, the other end of the first telescopic rod 2142 is connected to the puncture needle 2141, the first telescopic rod 2142 drives the up and down movement of the puncture needle 2141, and the puncture needle 2141 is installed at the bottom of the capsule chamber 212 dedicated to detection.

3. The fixing mechanism 215 includes a first presser plate 2151 and a second telescopic rod 2152.

2. The device for storing a chemical for preserving nattokinase activity according to claim 1, wherein one end of the second telescopic rod (2152) is connected to the inside of the box cover (2) and the other end of the second telescopic rod (2152) is connected to the first holding plate (2151), the second telescopic rod (2152) drives the left and right movement of the first holding plate (2151), and the first holding plate (2151) is installed on the right side inside the capsule chamber (212) dedicated to detection.

4. The fixing mechanism 215 further includes a second presser plate 2153 and a third telescopic rod 2154.

4. The device for storing a chemical for preserving nattokinase activity according to claim 3, wherein one end of the third telescopic rod (2154) is connected to the inside of the box cover (2), the other end of the third telescopic rod (2154) is connected to the second holding plate (2153), the third telescopic rod (2154) drives the left and right movement of the second holding plate (2153), and the second holding plate (2153) is installed on the left side inside the capsule chamber (212) dedicated to detection.

5. The device for storing chemicals for preserving nattokinase activity according to claim 1, wherein the signal reading unit 215 includes an optical sensor and an MCU controller.

6. 2. The storage device for chemicals for preserving nattokinase activity according to claim 1, wherein the wall of the desiccant inner tray chamber (12) is provided with fine holes, so that the desiccant exchanges moisture with the main chamber (11) but is physically isolated.

7. placing a nattokinase capsule into the detection-only capsule chamber 212; starting a detection program by means of said control button 217; Fixing the capsule in the detection-only capsule chamber 212 by the fixing mechanism 215; piercing the capsule with the sampling mechanism 214 and causing its contents to fall onto the detection unit 213; The detecting unit 213 obtains the optical signal generated by the action of the contents through the signal reading unit 216; processing the optical signal to obtain a nattokinase activity result; outputting the activity result by the display mechanism 22; 2. The device for storing chemicals for preserving nattokinase activity according to claim 1, further comprising:

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