Compositions and methods for cancer diagnosis

Abstract

The present disclosure provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to gangliosides (e.g., GD2 or GD3), as well as compositions comprising same and methods of using same for diagnostic and prognostic purposes. In addition, the present disclosure provides mass spectrometry-based methods for detecting various gangliosides and their lipid length, the changes of which are useful for the cancer diagnostic and prognostic methods described herein. The present disclosure further provides compounds comprising modified versions of gangliosides.

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