MICROBIOME-SUPPORTED TOPICAL WOUND AND BURN CARE EMULSION FORMULATION

Abstract

The invention relates to a multi-component topical emulsion formulation developed for use in superficial wound and burn care, epidermal irritation, and after dermocosmetic procedures. The formulation consists of a plant lipid phase, a bacterial lysate phase, a resin-based active phase, a hydrophilic active phase containing panthenol, and a hydrolyzed plant protein phase arranged within the same emulsion matrix in a dermatologically acceptable carrier. The formulation also includes plant essential oil and resin phases, vitamin and antioxidant phases, and auxiliary components that regulate the emulsion structure. This formulation is in the form of a cream or fluid emulsion containing both oil and water phases and is prepared within a skin-compatible pH range.

Description

Microbiome-Supported Topical Wound and Burn Care Emulsion FORMULATION TECHNICAL FIELD The invention relates to the technical field of topical dermatological and dermocosmetic preparations. and more specifically, superficial wound and burn care, as well as epidermal irritation and Multi-component cream or fluid used after dermocosmetic procedures. It relates to emulsion formulations. The invention involves a plant lipid phase containing bacterial lysate. microbiome support phase, natural antimicrobial resin phase, epithelialization and moisturizing phase, protein matrix support phase, essential oil and resin phase, and vitamin and bringing together the antioxidant phase in a dermatologically acceptable carrier. This relates to the topical emulsion formulation that it brings. STATE OF THE ART Care of superficial wounds and burns, as well as epidermal irritation and dermocosmetics. Topical preparations used after procedures protect the skin surface and provide moisture. various active ingredients aimed at maintaining balance and repairing damaged epidermal tissue It includes components and carrier systems. In known techniques, propolis, vegetable oils, Dexpanthenol, bacterial fermentation products, plant extracts and vitamins, single creams, ointments, gels, hydrogels, organogels, applied to the head or in various combinations and is used in emulsion structures. “Compositions for the topical treatment of” publication number EP0510318B1 The patent document titled "burns" contains Ahnfeldtia concinna gel and propolis. Topical burn compositions are described. The document discusses the two aforementioned compositions. aloe, placenta and gel structures in which the components are combined in different weight ratios There are application examples that include additional components. This document describes propolis. It indicates its use in gel-based compositions for burn care. “Dermatological preparation for the publication number WO2004022034A1 In the patent document titled "treatment of skin lesions," propolis extract is described as a herbal ingredient. dermatological preparations containing extracts, vegetable oils, antibiotics and vitamins It is explained in the document that propolis and herbal extracts are treated with paraffin, petrolatum, an ointment in which lanolin is used together with carrier components such as cholesterol and vegetable oil. 1 and aerosol applications are included. “Anti-burn” with publication number RU2248198C2. The patent document titled "preparation" mentions propolis, beeswax, and vegetable oil. These publications describe compositions of anti-burn ointments containing the following ingredients: propolis in topical preparations together with plant lipids and various excipients This indicates that its use falls within the known technical scope. Titled “Medicated propolis oil composition” with publication number US10888590B2 The patent document lists propolis, carrier oil, analgesic, surfactant, and The document describes medicated propolis oil compositions containing diluents. The use of propolis in an oil-based carrier system for wound care. and the fact that this system can be prepared in different topical forms, including creams. It is receiving. TR2022020852A2 and WO2024144676A1 publications belonging to the same patent family. number “Hydrogel and organogel formulations containing propolis and In documents titled "Dexpanthenol Nanoemulsions," propolis and dexpanthenol are discussed. nanoemulsions containing these substances are used in hydrogel or organogel structures. Formulations are described. These documents describe the combination of propolis and dexpanthenol. the use of these components in nanoemulsion-based gel carrier systems It shows the inclusion. US20220152129A1 and US11766465B2 publications belonging to the same patent family. numbered “External composition for wound healing containing lactobacillus fermentation product and method for promoting wound healing using the same” In the documents titled [title], the bacteria in the Lactobacillus plantarum fermentation product External compositions containing concentrated filtrate that does not contain external compositions are described. The document states that the fermentation product in question is processed in various carriers. Its use and applications in wound healing are discussed. Patent number WO2025128710A2 titled “Bacterial strains for skin health” The document mentions Lactobacillus argentoratensis HL-198 or Enterococcus avium. Hydrogel systems containing lysates or extracts obtained from HL-95 strains, and Their applications on damaged or inflamed skin are explained. This publications, bacterial fermentation products and lysates for topical skin care It has been shown that its use in compositions is within the known technical framework. It places. 2 Patent number US20070286838A1 titled “Tamanu Oil Products” in the document dermatological compositions containing tamanu oil and other components It is explained in the document that Tamanu oil is used in various topical preparations. includes its use and applications for skin, hair or nail care. It is given in publication number US9855309B2, “Compositions comprising extracts of boswellia, tea tree, aloe and lavender oil and methods of treating wounds, burns In the patent document titled "and skin injuries therewith," Boswellia, Tea Tree oil, compositions containing aloe and lavender oil, and their use in ointments, lotions, and creams. or its use in forms such as wound dressings is explained in these documents. Tamanu oil and Boswellia essential oils in dermatological preparations It constitutes previous technical examples of its use. Titled “Stable wound healing ointment” with publication number US12295924B2 The patent document describes stable wound care ointment systems. The document lists panthenol, allantoin, bisabolol, hyaluronic acid, propolis, and vitamins A, C, and E. vitamins and various plant substances, alone or in combination It appears to be among the components that can be used. When existing previous technical documents are evaluated together, propolis, panthenol, tamanu oil, bacterial fermentation products, Boswellia, and various It appears that the use of vitamins in topical preparations is known. With this... together, clearly and directly in the documents mentioned above It is not explained. Therefore, these components are the same within specific weight ranges. a topical emulsion matrix is ​​formed by combining the lipid phase and the bacterial lysate phase. natural resin phase, epithelialization and moisturizing phase, protein matrix support phase, A formulation structure containing both essential oil and vitamin phases is needed. It is heard. THE TECHNICAL PROBLEM THAT THE INVENTION AIMED TO SOLVE Superficial wound and burn care, as well as epidermal irritation and dermocosmetics. Topical preparations used after procedures help maintain the lipid and moisture levels of the skin surface. maintaining balance, supporting the epidermal barrier, microbiome balance maintenance and repair of damaged tissue using different active ingredients 3 Their use is known. However, these components have different physicochemical properties. possessing these qualities, fat-soluble and water-soluble substances, bacterial ferment derivatives, plant resin extracts, and protein derivatives are used topically in the same application. arrangement of the carrier system in a physicochemically compatible manner It requires. Propolis and vegetable oil-based ointments, produced using conventional techniques, contain panthenol. preparations, external compositions containing bacterial fermentation products and herbal preparations Extract-based skincare products utilize different groups of active ingredients. However, these approaches involve the lipid phase, the microbiome support phase, and the natural phase. resin phase, epithelialization and moisturizing phase and protein matrix support phase are the same Specific requirements for their coexistence within a cream or fluid emulsion structure. It does not necessarily reveal a formulation order. Therefore, the technical problem that needs to be solved is: Tamanu oil, bacterial such as lysate / ferment derivative, propolis extract, panthenol and hydrolyzed vegetable protein. groups of active ingredients with different physicochemical properties, dermatologically that they can coexist within a certain weight range in an acceptable carrier, oil and water phases are arranged within an emulsion structure, with a skin-compatible pH. It has a wide range and can be prepared in cream or fluid emulsion form. It is the creation of a multi-component topical formulation. However, with plant essential oils and resin components, as well as vitamins and The ability of antioxidant components to be incorporated into the topical matrix in question, emulsifier, thickener, humectant, pH regulator and preservative additive. The technical aspects also include the regulation of the physicochemical structure of the formulation with the substances. It is within the scope of the problem. A BRIEF DESCRIPTION OF THE INVENTION The invention relates to the care of superficial wounds and burns, as well as epidermal irritation and dermocosmetics. a dermatologically acceptable carrier used after procedures a topical cream or liquid containing different groups of active ingredients together It relates to emulsion formulation. The formulation subject to the invention shall be such that the total by weight is 100%; by weight 10.0–20.0% Tamanu oil (Calophyllum Inophyllum Seed Oil), 1.0–10.0% by weight. 4 Lactobacillus ferment lysate, 1.0-7.0% by weight. Propolis extract contains 1.0-8.0% panthenol by weight. 1.0-8.0% by weight of hydrolyzed vegetable protein. 0.5–4.0% by weight Niaouli oil (Melaleuca Viridiflora Leaf Oil), 0.1–3.0% by weight Boswellia Carterii oil and retinyl in a total concentration of 0.5-4.5% by weight. acetate (Retinyl Acetate), sodium ascorbyl phosphate (Sodium Ascorbyl Phosphate) and Contains vitamin A / C / E complex including tocopheryl acetate. These components are dermatologically acceptable carriers and It is present in the same topical emulsion matrix along with the excipients. Tamanu oil is included in the lipid phase of the formulation and is a skin lipid component. to support the barrier and create a softening protective layer on the epidermal surface It is used to form a layer. Lactobacillus Ferment Lysate, a microbiome support product, is a lysate / ferment derivative that does not contain live bacteria. It is located in the propolis extract phase, which is a natural antimicrobial and resin phase. Panthenol is involved in the epithelialization and moisturizing phase; while Hydrolyzed Vegetable Protein is involved. The protein matrix forms the support phase. Niaouli oil and frankincense oil are the plant-based essential oils and resins in the formulation. It is included in the support phase. The A / C / E vitamin complex contains retinyl acetate and sodium. It consists of ascorbyl phosphate and tocopheryl acetate components, and the formulation... It forms the vitamin and antioxidant phase. The formulation is also available in concentrations of 0.5-3.0% by weight for preferential applications. A sedative support phase containing bisabolol and / or allantoin at a concentration of 0.1–1.0% by weight. with a humectant and water-retaining support phase containing 2.0-10.0% by weight of glycerin. It contains. The formulation also contains a total of 1.0-8.0% by weight of emulsifiers and thickeners. It contains regulatory components. These include emulsifiers and thickening agents. The components arrange the oil and water phases within the emulsion structure and It ensures the formation of the consistency and rheological properties of the formulation. In preferred applications, the formulation consists of disodium EDTA and sodium hydroxide. or chelate containing citric acid, pH and stabilization phase and total amount the formulation is based on phenoxyethanol and ethylhexylglycerin, which constitute 0.3-1.2% by weight. It may include a protective system. The pH value of the formulation should preferably be 5.0-6.8, or even better, 5.5-6.5. It is within this range. The formulation is in the form of cream, fluid, gel-cream, lotion or emulsion. It can be prepared. Deionized water, along with the other components, forms the formulation. It is present in an amount that completes the total by weight to 100%. DETAILED DESCRIPTION OF THE INVENTION The invention relates to the care of superficial wounds and burns, as well as epidermal irritation and dermocosmetics. dermatologically tested groups of different active ingredients used after the procedures topical cream or fluid containing together in an acceptable carrier This relates to emulsion formulation. The formulation consists of a plant lipid phase and a bacterial lysate. microbiome support phase, containing natural antimicrobial resin phase, epithelialization and The moisturizing phase and the protein matrix support phase are in the same topical emulsion matrix. It brings them together within. In preferential applications, volatile elements are added to this matrix. Oil and resin support phase, vitamin and antioxidant phase, soothing support actives, humectants and auxiliaries that regulate the physicochemical structure of the formulation Components are also included. The formulation subject to the invention will have a total weight of 100%. It is prepared in a dermatologically acceptable carrier. In this statement All weight percentage values ​​given are, unless explicitly stated otherwise, of the respective component. or expresses the quantity of a component group relative to the total weight of the formulation. This involves describing the components in terms of functional phases, which ultimately lead to... does not require the product to be in the form of physically separated layers and these components are together within the same topical emulsion matrix. It is located. The cicatrizing lipid and barrier repair phase of the formulation contains 10.0-20.0% by weight. It contains Calophyllum Inophyllum Seed Oil (Tamanu oil) in a specific percentage. Tamanu The oil constitutes the plant-based lipid component of the formulation and helps maintain the skin's lipid barrier. to provide support, a softening and protective layer in superficial wound or burn areas. to support the creation and formation process of new tissue is used. This oil is incorporated into the oil phase of the formulation, unlike the others. It is located within the same emulsion matrix as the active ingredients. The microbiome support phase of the formulation contains 1.0-10.0% by weight. Contains Lactobacillus Ferment Lysate. Lactobacillus Ferment Lysate contains live bacteria. 6 It is used as a bacteria-free lysate / ferment derivative and is beneficial for the skin microbiome. component aimed at supporting the balance and epidermal defense response It forms the group. In preferential applications, in the microbiome support phase. Instead of or in combination with Lactobacillus Ferment Lysate, Lactobacillus ferment filtrate, Lactobacillus lysate, or probiotic / postbiotic ferment that does not contain bacteria. Derivatives can be used. These alternatives include bacterial ferment derivative components. It constitutes the different applications of the group and is used in the final formulation. The nature of the derivative is determined according to the relevant application. The natural antimicrobial and resin phase of the formulation is 1.0-7.0% by weight. It contains a certain percentage of Propolis Extract. Propolis extract is a natural antimicrobial, as a resin-based active ingredient providing antioxidant and tissue repair support Propolis extract is used in aqueous, glycerol, hydroalcoholic or suitable lipophilic forms. It can be found in a dissolved or dispersed form in the carrier. The extract carrier form, together with the other components of the formulation and the emulsion structure. is being evaluated. The epithelialization and moisturizing phase of the formulation is 1.0-8.0% by weight. It contains Panthenol in a certain percentage. Panthenol is involved in epidermal renewal, moisture retention, It is used for barrier comfort and epithelialization support. Preferential In one application, the Panthenol component is D-Panthenol. Panthenol is a component of the formulation. together with other active ingredients in the same topical emulsion matrix It is located. The protein matrix support phase of the formulation contains 1.0-8.0% by weight. Contains Hydrolyzed Vegetable Protein. Hydrolyzed vegetable protein, vegetable It is used as a component for keratin / protein matrix support and in damaged areas. supporting the reconstruction of tissue integrity at the epidermal surface It is included in the formulation for this purpose. Hydrolyzed vegetable protein; hydrolyzed wheat protein, hydrolyzed soy protein, hydrolyzed rice protein, hydrolyzed corn protein The protein can be selected from hydrolyzed pea protein or a mixture of both. In a preferred application, the formulation contains antiseptic and soothing essential oil phases. Contains 0.5-4.0% by weight of Melaleuca Viridiflora Leaf Oil (Niaouli oil) and contains 0.1-3.0% Boswellia Carterii oil by weight. Niaouli oil is used for its antiseptic and epidermal soothing properties. 7 Boswellia oil, on the other hand, provides anti-inflammatory support and helps reduce the tendency of scarring / keloids. It is used as a care component for this purpose. These components are part of the plant-based formulation. Essential oils and resins form the support group. In a preferential application, the formulation contains 0.5-4.5% of the total by weight. It contains a vitamin A / C / E complex. The vitamin complex contains Retinyl Acetate (Vitamin A). A), Sodium Ascorbyl Phosphate (stable Vitamin C) and Tocopheryl Acetate (Vitamin E) contains the components. This vitamin complex contains the vitamins of the formulation. and forms the antioxidant phase, providing antioxidant protection, cellular regeneration, and It is used to support collagen synthesis. The stated amount is 0.5% by weight. The range 4.5 represents the total amount of the complex. The formulation is also available in concentrations of 0.5-3.0% by weight for preferential applications. It may contain bisabolol and / or 0.1–1.0% allantoin by weight. Bisabolol, It is used to soothe sensitivity and redness. Allantoin, on the other hand, aims to support epidermal comfort and surface repair. These components are used as ingredients. These components provide soothing and supportive effects to the formulation. It forms the active phase. The humectant and water-retaining support phase of the formulation contains 2.0-10.0% by weight. It may contain glycerin and preferably sodium hyaluronate in proportion to the specified percentage. The components are located within the hydrophilic phase of the formulation. The formulation contains a total of 1.0-8.0% by weight of emulsifier and thickener. It may contain regulatory components. These components include Cetearyl Alcohol, Ceteareth- Contains 25, Glyceryl Stearate and Carbomer. Emulsifier and thickening agent. The components are within the emulsion structure of the oil and water phases of the formulation. in the regulation, consistency adjustment and creation of rheological properties is used. The quantity of these components depends on whether the formulation is cream, fluid, or gel. This is determined according to the form of cream, lotion, or emulsion. The formulation contains 0.01-0.2% by weight in the chelate, pH, and stabilization phases. Disodium EDTA at a certain percentage and Sodium Hydroxide at a rate of 0.05-1.0% by weight or It may contain citric acid. These components are important for pH control and rheological aspects of the formulation. It is used for the purpose of balancing and stabilizing the pH of the formulation. The value is preferably in the range of 5.0-6.8, and even more preferably in the range of 5.5-6.5. 8 The formulation contains a total amount of 0.3-1.2% of the formulation's weight. It may contain a preservative system including phenoxyethanol and ethylhexylglycerin. The preservative system constitutes one of the auxiliary components of the formulation. The hydrophilic carrier phase of the formulation contains Deionized Water / Aqua. Deionized water, dissolution of hydrophilic actives, external phase of emulsion. to create and ensure the fluid cream / fluid character of the product It is used as follows: Deionized water, along with other components in the formulation. It contains an amount that makes the total by weight reach 100%. In a preferred application, the formulation should contain 10.0-20.0% by weight of Tamanu oil. 1.0-10.0% by weight Lactobacillus Ferment Lysate, 1.0-7.0% by weight Propolis Extract, 1.0-8.0% by weight; Panthenol, 1.0-8.0% by weight; Hydrolyzed Vegetable Extract. Protein, 0.5-4.0% by weight; Niaouli oil, 0.1-3.0% by weight; Boswellia oil, by weight. Total 0.5-4.5% vitamin A / C / E complex, totaling 1.0-8.0% by weight. emulsifier and thickening agents and formulation 100% by weight. It includes complementary carrier and auxiliary phases. In this application, the following is the case... The active ingredient groups are not in separate products, but in the same topical emulsion matrix. They are located together within it. The formulation is a cortisone and antibiotic-free option for preferential applications. It can be prepared as a composition. Mineral oil or petrolatum are essential components. also not used as carrier systems based on plant lipid and emulsion phases. It is included in the formulation. In these applications, the lipid phase is Tamanu oil. It is formulated with plant-based lipid components. The subject matter of the invention is a formulation of cream, fluid, gel-cream, lotion, emulsion or It is available in serum-cream form. Areas of use for the formulation. among them are superficial wounds, first-degree or superficial second-degree burns, sunburns. burns, epidermal irritation, sensitivity after hair removal, after laser treatment sensitivity, dermabrasion, microneedling and other non-invasive or minimally invasive procedures Skin barrier disruptions occurring after invasive dermocosmetic procedures It is a topical care product formulation intended for these areas of use. It is defined as any surgical or therapeutic application method This is not a mandatory element of this statement. 9 The formulation subject to the invention consists of the specified weights of the components described. It is a composition in which the active ingredients are present together within the same topical emulsion matrix at different intervals. The formulation preferably includes Niaouli oil, Frankincense oil, and vitamins A / C / E. complex, soothing support components, humectants, emulsifiers, thickener regulators, pH regulators and preservative systems as described above They are present in certain quantities. The quantities of components and excipients are: The total weight of the formulation is determined to be 100%. The table below shows how the components relate to their total formulation weight. It was prepared to show that it can be concretized. Values ​​proposal It is a qualitative assessment; it is not the final prescription. Component Sample by weight (%) Calophyllum Inophyllum Seed Oil (Tamanu oil) 10.00 Lactobacillus Ferment Lysate 3.00 Propolis Extract 1.50 D-Panthenol 6.00 Hydrolyzed Vegetable Protein 1.50 Melaleuca Viridiflora Leaf Oil (Niaouli oil) 0.60 Boswellia Carterii Oil (Frankincense oil) 0.20 Vitamin A / C / E complex (total) 1.00 Bisabolol 0.60 Allantoin 0.30 Glycerin 4.00 Sodium Hyaluronate 0.10 Cetearyl Alcohol 2.00 Ceteareth-25 1.50 Glyceryl Stearate 2.00 Carbomer 0.20 Disodium EDTA 0.05 Phenoxyethanol / Ethylhexylglycerin 1.00 pH regulator 0.20 Deionized water 64.25 Total 100.00

Claims

1. It is a topical cream or fluid emulsion formulation, characterized by: based on the total weight of the formulation; - 10.0-20.0% by weight of Tamanu oil (Calophyllum Inophyllum Seed) Oil), - 1.0-10.0% by weight Lactobacillus ferment lysate (Lactobacillus Ferment Lysate), - 1.0-7.0% by weight of propolis extract. - 1.0-8.0% panthenol by weight. - 1.0-8.0% by weight hydrolyzed vegetable protein Protein), - 0.5-4.0% by weight of Niaouli oil (Melaleuca Viridiflora Leaf Oil), - 0.1-3.0% by weight of Boswellia Carterii oil. - total retinyl acetate at 0.5-4.5% by weight, sodium ascorbyl phosphate and tocopheryl Vitamin A / C / E complex containing tocopheryl acetate. - total 1.0-8.0% by weight of emulsifiers and thickeners. components and - deionized water in an amount that completes the formulation to 100% by weight. It is a topical emulsion formulation containing...

2. Topical emulsion formulation according to claim 1, its characteristic is; panthenol The component of (Panthenol) is D-panthenol (D-Panthenol).

3. It is a topical emulsion formulation according to claim 1 or 2, and its characteristic is; hydrolyzed vegetable protein component hydrolyzed wheat protein, hydrolyzed soy protein, hydrolyzed rice protein, hydrolyzed corn protein, hydrolyzed pea protein, or mixtures thereof It is the selection process.

4. Topical emulsion formulation according to any of the previous requirements. Its characteristic is that propolis extract is aqueous, glycerol-based. in a dissolved or dispersed form in a hydroalcoholic or lipophilic carrier It is the presence of. 11 5. Topical emulsion formulation according to any of the previous requirements. Its characteristic feature is that it also contains 0.5-3.0% bisabolol by weight. It contains 0.1-1.0% allantoin by weight.

6. Topical emulsion formulation according to any of the previous requirements. Its characteristic feature is that it also contains 2.0-10.0% glycerin by weight. It includes.

7. Topical emulsion formulation according to any of the previous requirements. Its characteristic feature is that the emulsifier and thickening components are cetearyl alcohol. (Cetearyl Alcohol), cetearyt-25 (Ceteareth-25), glyceryl stearate (Glyceryl It contains stearate and carbomer.

8. Topical emulsion formulation according to any of the previous requirements. Its characteristic feature is that its pH value is in the range of 5.0-6.

8.

9. It is a topical emulsion formulation according to claim 8, and its characteristic feature is that the pH value is... It should be in the range of 5.5-6.

5.

10. Topical emulsion formulation according to any of the previous requirements. Its characteristic feature is that it also contains 0.01-0.2% disodium EDTA by weight. (Disodium EDTA) and 0.05-1.0% by weight of sodium hydroxide (Sodium It contains either hydroxide or citric acid.

11. Topical emulsion formulation according to any of the previous requirements. Its characteristic feature is that its total amount is 0.3-1.2% by weight of the formulation. phenoxyethanol (Phenoxyethanol) and ethylhexylglycerin (Ethylhexylglycerin) It contains a protective system. 12