Systems for upper lip lift procedures and methods of their use

Abstract

The disclosure herein provides marking system(s) for use in guiding upper lip lift procedure(s) optionally accompanied by corner lip lift(s) or ancillary procedures such as nasal base suspension or muscle suspension procedure(s). Marking system(s) herein simplify complex and artistic decision-making process(es) related to upper lip lift and comer lift procedures by applying mathematical guidelines and principles to establish natural, aesthetically pleasing balanced appearance of the upper lip. The disclosure further provides method(s) of establishing marking system(s) and method(s) of their use in procedures such as upper lip lifts, e.g., combined deep plane release subnasal and comer lip lifts, utilizing a bull's horn surgical incision design. In certain aspects, the disclosure provides automated system(s) comprising programmed algorithms describing marking system(s) or from which marking system(s) are established or otherwise derived. In aspects, the disclosure provides system(s) comprising technology (ies) capable of reliably predicting aesthetic outcome(s) of procedure(s) incorporating marking system(s).

Description

SYSTEMS FOR UPPER LIP LIFT PROCEDURES AND METHODS OF THEIR USETransformative Legal Reference No.: CLL23191WOWBZRELATED APPLICATIONS / PRIORITY

[0001] This patent application claims priority to U.S. Provisional Patent Application No. 63 / 499,915 filed May 03, 2023, entitled “MARKING SYSTEMS FOR UPPER LIP LIFT PROCEDURES AND METHODS OF THEIR USE.” This application claims the benefit of priority to the above-referenced application.FIELD OF THE INVENTION

[0002] This disclosure primarily relates to aesthetic modification surgery(ies), specifically upper lip lift procedure(s), and guides for use therein, wherein such guide(s) increase the predictability of the aesthetic outcome(s) resulting from the procedure(s).BACKGROUND OF THE INVENTION

[0003] Cosmetic modification of human appearance dates back thousands of years, with the earliest documented procedures directed to cosmetic repair dating back to as early as 2000 to 3000 B.C. Procedures to fix identified disfigurements began to take hold and expand approximately 200 years ago. According to certain sources, the first cosmetic surgery was performed by John Peter Mettauer in 1817. Beginning in the 1970s, elective cosmetic surgeries became far more regular and commonplace. Since this time, as cultural emphasis on aesthetic appearance has grown, the forms and methods of aesthetic modification have ballooned, and millions of procedures have been performed.

[0004] As technology has developed, numerous forms of aesthetic modification and related procedures have been introduced, ranging from e.g., relatively simple superficial aesthetic modification of the skin, to the use of fillers, to far more advanced and complex surgical interventions such as facelifts.

[0005] A commonly desired modification sought by patients is a modification of the appearance of a subject’s lips. The origins of injectable lip fillers can be traced back to the early 19111century, with the earliest of such products comprising fat. Lip augmentation using silicone fillers began in the 1960s, with bovine collagen fillers launching in the 1980s. However, while far less invasive than other surgical procedures, in recent years, there has been an emergence of patients suffering the negative effects of fillers.

[0006] One alternative to lip fillers is the surgical procedure referred to as an upper lip lift, an aesthetic modification procedure that has been performed for over four decades. Patients seeking such a procedure often present with excess lip length and drooping, complaining of looking tired and aged. Common patient complaints include chronically long or heavy upper lip, poor tooth show / dental hooding, over-filled lips / poor filler results, filler complications, postsurgical drooping (rhinoplasty / orthognathic), a poorly defined or thin upper lip, asymmetry, buried or drooping comers of the mouth, and upper lip incompetence. An elongated upper lip can lengthen the appearance of the entire midface. Lack of tooth show can exaggerate an aged appearance and can dramatically diminish sensuality. As the lip lengthens, it also tends to display diminished function while losing character and definition of the lip feature identified in the art as Cupid’ s bow.

[0007] An upper lip lift procedure requires the surgeon / s) to make an independent assessment regarding the optimal degree of lift and adjustment of each region of the upper lip. Unfortunately, lip lift techniques must address complicated obstacles in order to achieve such targeted effect(s). Traditional lip lift techniques have been criticized and often avoided out for fear of visible scarring which can negatively impact the resulting appearance. Improperly performed procedures can leave patients with a significantly “artificial” look, scaring many patients away from such procedures. While many modified versions of the upper lip lift have been presented in attempts to resolve such challenges and provide more natural-looking results, very few of the numerous variations of the procedure considered and attempted consistently provide aesthetically natural and reproducible results.

[0008] The bullhorn subnasal lip lift, described in 1971 by Cardoso and Sperli, was one of the first techniques to take hold as providing the degree and efficacy of aesthetic modification targeted by practitioners and patients. Several renditions of the bullhorn have since followed, each with the goal of reducing incision length, limiting scarring, and enhancing the degree of lift. Unfortunately, however, most of these techniques have a tendency toward nasal base effacement and scarring that is difficult to repair. Furthermore, the results of said procedures have failed to provide consistent and predictable patient results.

[0009] In 2014, Dr. Benjamin Talei reported on a technique in which he modified the bullhorn subnasal lip lift which resulted in significant improvement in results and consistency. The technique is described in, “The Modified Upper Lip Lift - Advanced Approach with Deep- Plane Release and Secure Suspension: 823-Patient Series,” (See: Facial Plast Surg Clin N Am 27 (2019) 385 - 398.) The modified upper lip lift is based on the classic bullhorn incision with afocus on deeper and more extensive release of the upper lip and more definitive suspension. The modified upper lip lift is a centrally vectored deep-plane advancement flap technique focused on releasing tension in the skin and uniformly redistributing the skin once tethering is released. A limited group of short, preoperative radial vector markings were designed and depicted by the author in the above-referenced 2019 publication for use in guiding generally uniform excision(s) in the procedure. The reference marking system disclosed in the 2019 publication comprises markings based on the classic bullhorn lip lift technique and includes an upper incision reference; a lower incision reference; and a total of 9 radially spaced short reference hashes. The markings are described on pages 391 and 392 of the 2019 publication and for ease of reference are provided as Figures 1A, IB, and 1C in the present application. Radially spaced hash markers of the previously presented marking system extend from the nasal base to the mid-upper lip. A portion of the lip, notably uniform in height, is identified by the marking system(s) described therein. See specifically Fig. 22 of the 2019 publication. As relevant procedure(s) were described in this publication, the publication is incorporated herein by reference in its entirety.

[0010] In early applications of the modified subnasal lip lift technique, the limited markings accompanying the procedure were identified as essential to optimizing outcomes. Unfortunately, however, while some procedures are deemed successful by both the subject and the practitioner, Dr. Talei observed that such methods did not address all of the issues sought to be overcome by such methods. Application of the procedure and its accompanying marking system sometimes yielded inconsistent or unpredictable results. As the stakes and costs of such procedures are high, the risk-benefit analysis of the procedure as previously described is in question. Thus, in sum, including the present inventor’s previous work, no alternative upper lip lift techniques have led to a satisfactory solution for addressing inconsistent and unpredictable results and accompanying complications such as, e.g., increased scarring, related to the traditional bullhorn upper lip lift technique. Patients are left to risk unpredictable results or to live with an aesthetic appearance that is functionally problematic or deemed physically unappealing.

[0011] Accordingly, there is a need in the art for alternative approaches to this issue. As described here, many modifications of the traditional bullhorn technique have been considered and applied with no apparent success in addressing the aforementioned issues, thus demonstrating the degree of difficulty related to addressing the aforementioned issues. Resolution of such matters requires inventive ingenuity and deep familiarity and experience with the nuances of such procedures.SUMMARY OF THE INVENTION

[0012] This document includes a section entitled “CONSTRUCTION PRINCIPLES AND DESCRIPTION OF SELECT TERMS” that readers are encouraged to consult to help properly interpret the disclosure provided in this section and elsewhere here. That section includes acronyms that may be present in this disclosure.

[0013] This “Summary of the Invention” section (“Summary”) briefly describes the elements and characteristics of selected illustrative embodiment(s) of this disclosure. The brief summaries of such embodiments provided here are primarily intended to illustrate the nature of systems, methods, and the like provided herein, which may be used to define claimed / claimable inventions, and, accordingly, the content of this Summary is not intended to be all-inclusive, and the scope of the disclosure herein or any invention claimed therefrom is not limited to, or by, the exemplary aspects of the disclosure provided in this section. Any of the aspects of the disclosure described in this section can be combined with any other aspect described in this or any other aspect of this disclosure.

[0014] In aspects, the disclosure herein provides marking system(s) for use in guiding upper lip lift procedure(s), e.g., subnasal lip lift procedure(s) optionally accompanied by corner lip lift(s) (e.g., subnasal and corner lift procedures), further optionally accompanied by one or more additional procedures such as a nasal base suspension, muscle suspension, or both, wherein the marking system(s) simplify(ies) complex and artistic decision-making process(es) related to upper lip lift and comer lift procedures, wherein mathematical guide(s) and principle(s) are applied in the establishment of a natural, aesthetically pleasing balance of the upper lip which optimizes muscle function and determines whether comer lift procedure(s) are appropriate for concomitant performance with a subnasal upper lip lift in order to achieve target result(s). In aspects, marking system(s) and method(s) of their use herein elucidate aesthetic design elements related to upper lift aesthetic modification procedure(s) and address concern(s) related to longterm resistance to aging. In aspects, the disclosure provides system(s) and method(s) of establishing such marking system(s) and method(s) of their use in procedures such as, e.g., upper lip lifts, e.g., subnasal upper lip lifts, e.g., deep plane release subnasal upper lip lifts, e.g., combined deep plane release subnasal and comer lip lifts, e.g., those provided here utilizing a bull’s horn surgical incision design, wherein such procedure(s) can, in aspects, be accompanied by one or more ancillary procedure(s) such as a nasal base suspension, muscle suspension, or both.

[0015] According to aspects, the disclosure herein provides marking system(s) / method(s) for use in guiding upper lip lift procedure(s), e.g., subnasal lip lift procedure(s) optionally accompanied by comer lip lift(s) (e.g., subnasal and comer lift procedures), further optionally accompanied by one or more additional procedures such as a nasal base suspension, muscle suspension, or both, wherein the marking system(s) provide for controlled, precise, identification of excision(s) associated with an upper lip lift procedure(s) which is / are often characterizable as non-uniform (e.g., height(s) of a plurality of area(s) of a bullhorn excision are not uniform between the left- and right sides of the upper lip), yet yield(s) targeted, predictable aesthetic appearance characteristic(s) of the upper lip, such as, e.g., vermillion slope and tooth show.

[0016] In certain specific aspects, the disclosure provides a marking system for use on a human subject in the preparation for, execution of, or both preparation and execution of, an aesthetic modification of the upper lip by an upper lip lift procedure, the marking system comprising at least 7 radially spaced markings (markers) located between the nasal base which can in aspects be indicated by an upper excision boundary (002) and the upper vermillion border (020). In aspects, each of the at least 7 radial markings comprises at least 3 different points within its length. In aspects, the at least 3 different points within their lengths identify a first upper incision point along the nasal base (e.g., collectively defining an upper excision boundary (002)), a second lower incision point, and a third point located on the upper vermillion border (020) along each marker. In aspects, each of the at least 7 radial markings progresses from at least substantially vertical at the midline point of the Cupid’s bow trough with gradual radial rotation laterally towards the angle of the nasolabial fold(s) (016 A) and (016B) (respectively), following the lip’s natural relaxed tension lines, pores, or both. In aspects, the at least 7 radially spaced markings (markers) comprise at least (1) a first radial marking (“radial marking 1” (labeled in figure(s) as (006)) positioned in the middle of the columella and philtral dimple, at the lowest point of the trough of Cupid’s bow; (2) 2 radial markings (“radial marking 2A” (008A) and “radial marking 2B” (008B)) positioned lateral to and on either side of radial marking 1 (006), respectively, each located lateral to the columella at the peaks of Cupid’s bow and at the point where the medial crural footplates diverge into the nose at the junction with the alar sill; (3) 2 radial markings (“radial marking 3A” (010A) and “radial marking 3B” (010B)) positioned lateral to each of radial markings 2A (008A) and 2B (008B), respectively, such that the two radial markings 3A (010A) and 3B (010B) are positioned centrally between radial markings 2A (008A) and 4A (012A) and between radial markings 2B (008B) and 4B (012B), respectively; and (4) 2 radial markings (“radial marking 4A” (012A) and “radial marking 4B”(012B)) positioned lateral to each of radial markings 3A (010A) and 3B (010B), respectively, from the internal angle of the alar recurvature extending radially downward and following the natural curvature and natural tension lines, radial angulation of the pores of the upper lip, or combination thereof. In aspects, radial marking(s) 4A and 4B are at least substantially diagonal line(s). All markings to a first lateral side of the first radial marking (radial marking 1 (006)) are identifiable as a first group of markings (e.g., “group A markings”), and all markings to a second lateral side of the first radial marking are identifiable as a second group of markings (e.g., “group B markings”). In aspects, a pre-determined target aesthetic shape of the upper lip defines a distance between the second lower incision point and the third point located on the upper vermillion border (020) along each of the at least 7 radial markings. In aspects, the defined distance between the second and third points along each of the at least 7 radial markings defines a final height of the upper lip at the location of such marking (“final height portion” of such marking(s)). In aspects, the remaining distance along each of the at least 7 radial markings between the second point lower incision point and the first upper incision point define the excision height at the location of such marking (“excision height portion” of such marking(s)) and identifies the shape of a region to be excised (001) in the upper lip lift procedure resulting in the target aesthetic appearance. According to aspects, the target aesthetic shape is a target slope of the upper vermillion of between about 1 and about 3 such as about 2 between radial marker(s) 2A and 3A; 2B and 3B; 3A and 4A; and 3B and 4B. In aspect, the target aesthetic shape is a target incisor display of between about 1 mm and about 4 mm, such as about 2 mm - about 3 mm. In aspects, the target aesthetic shape is derived by length(s) of marking(s) yielding a height differential between the trough of the subject’s cupid’s bow and the peaks of the subject’s Cupid’s bow of between about 1 mm and about 3 mm, such as about 2 mm; a height differential between the dip of the columella beneath the nose of the subject and the points where the medial crural footplates diverge into the nose at the junction with the alar sill of the subject of between about 1 mm and about 3 mm, such as about 2 mm; or both. According to still more specific aspects, the marking system(s) provided herein comprise one or more additional marking(s) made lateral to one or both of markings 4A (012A) and 4B (012B), described herein as radial markers 5A and 5B, each essentially following the relaxed skin tension lines (RSTLs), extending downward from the apex of each lateral end of the nasal base.

[0017] In certain aspects, “marking system(s)” as they have been described here are virtual marking system(s) and are generated within the automated system(s) provided by this disclosure. In such embodiment(s), “marker(s)” or “marking(s)” represents the location(s) on ahuman face as described, wherein their characteristic(s) (such as length(s)) exist as manipulatable data within an automated system. In aspects, such system(s) are capable of being used to manipulate such data to generate and present morphed image(s), predicting the result(s) of aesthetic modification procedure(s) such as, e.g., upper lip lift procedure(s), e.g., deep plane release upper lip lift procedure(s), and optionally one or more ancillary procedure(s) such as corner lip lift procedure(s). In aspects, the pre-determined aesthetic shape of lip(s) discussed above is / are generated by automated system(s) and presented to the system user(s) for consideration prior to the conduct of an aesthetic modification procedure.

[0018] In certain aspects, the disclosure provides automated system(s) comprising programmed algorithms describing marking system(s) or from which marking system(s) are established or otherwise derived. In aspects, the disclosure provides system(s) comprising technology(ies) capable of predicting aesthetic outcome(s) of procedure(s) incorporating marking system(s) or result(s) generated by the definition(s) or constraint(s) making up such marking system(s). In aspects, the disclosure provides landmark recognition and image morphing technology(ies) providing subject(s) and practitioner(s) the ability to visualize ahead of time, and plan, outcome(s) of procedure(s) based on a selection of parameter(s) related to marking system(s) and their related algorithms.

[0019] In aspects, the disclosure provides an automated system for generating a plurality of measurements associated with at least 7 locations associated with the upper lip of a human face, the plurality of measurements being measurements which, when established by application of an upper lip lift aesthetic modification procedure to the human face provide an aesthetic appearance predicted by the automated system, the automated system comprising (1) processing and memory functionality; (2) landmark detection functionality; (3) visual guide(s) & measurement functionality; (4) image morphing functionality; (5) artificial intelligence-based calculation capability; and (6) data capture and retrieval functionality, wherein the automated system is designed to analyze an original image of at least the upper lip of a human face; apply landmark detection functionality to identify at least 7 specific locations on the image associated with dimensions of the upper lip of the human face; apply measurement functionality to the identified locations to obtain measurement(s) associated with the original image; morph the original image according to one or more input(s), rule(s), or setting(s) to establish a morphed image representing a target aesthetic appearance; and present data to the automated system user associated with modification(s) at one or more of the at least about 7 specific location(s) to be applied in the upper lip lift aesthetic modification procedure in order to obtain the target aestheticappearance predicted by the morphed image. In aspects, such as ~7 (5, 6, or 7) specific location(s) described here are location(s) associated with facial feature(s) identified by marker(s) of marking system(s) of the present disclosure; e.g., marking(s) 1, 2A, 2B, 3A, 3B, 4A, 4B, 5A, 5B, H-A, H-B, LE-A, LE-B, an upper excision boundary, and, e.g., the upper vermillion border. In aspects, the upper vermillion border has a slope between 2A and 3 A; 2B and 3B; 3 A and 4A; 3B and 4B, 4A and 5A; and 4B and 5B of between about 1-3, such as, e.g., about 2. In aspects, marker(s) 4A and 4B establish a boundary wherein within such boundary (between such marker(s)), the upper lip is particularly sensitive to lift, while outside of such boundary (lateral to such marker(s)) the subfacial lip and lateral mouth is less sensitive to lift.

[0020] In certain aspects, the disclosure provides marked-tip adjustable spacing devices (MT-ASDs) specifically designed for establishing marking(s) of the marking system(s) provided herein. In one specific aspect, the disclosure provides a marked-tip adjustable spacing device (MT-ASD) (600) for use in marking human skin comprising a minimum marking distance and a maximum marking distance, the MT-ASD comprising (1) two frame elements (640), (655), each having at least approximately the same size and shape, wherein (a) one frame element is movable (655) relative to the other (640) about a fixed point (680), and (b) the two frame elements (640), (655) exist in a device plane; (2) a marking end (650), (665) of each of the two frame elements (640), (655), respectively, wherein each marking end (650), (665) comprises a marking tip (685), (690), respectively, extending from each of the two marking ends (650) and (665) of the frame elements (640), (655), respectively, to form a pair of marking tips, wherein each marking tip (a) has a length; and (b) extends from each of the two frame elements (640), (655), respectively in a direction perpendicular the device plane, and wherein (c) the pair of marking tips (685), (690) are positioned parallel to one another at all times and are in physical contact with one another across the entirety of their length when the MT-ASD (600) is established at its minimum marking distance position, and further wherein marking tip(s) (685), (690), or both are coated with, covered by, or are made of a non-metal colorant application material (695); or marking end(s) (650), (665), or both, and marking tip(s) (685), (690), or both are coated with, covered by, or are made of a non-metal colorant application material (695), wherein the non-metal colorant application material is capable of maintaining an effective amount of a colorant (710) such that when the colorant (710) is present on one or both of marking tip(s) (685) and (690), the MT- ASD (600) applies visible markings to human skin when the MT-ASD (600) is in use.

[0021] In certain aspects, the disclosure provides kit(s) comprising one or more MT- ASD(s) provided herein and one or more sources of colorant, such as, e.g., one or morecontainers of colorant, such as container(s) comprising free, liquid colorant, liquid colorant maintained by a matrix or substrate such that the liquid colorant cannot be easily spilled from a container, or both.

[0022] Relevant procedure(s) were described in, “CUPID Lift: Advanced Lip Design Using the Deep Plane Upper Lip Lift and Simplified Comer Lift,” authored by the present inventor (see Talei B, Pearlman SJ. CUPID Lip Lift: Advanced Lip Design Using the Deep Plane Upper Lip Lift and Simplified Comer Lift. Aesthet Surg J. 2022 Dec 14;42(12): 1357- 1373. doi: 10.1093 / asj / sjacl26. PMID: 35583637). Accordingly, this reference is also incorporated by reference herein in its entirety. Modifications made to the bullhorn subnasal lip lift technique set forth herein allow a significantly wider application(s) of such a procedure (e.g., in terms of suitable patients), the procedure previously having been reserved primarily for elderly patients with light skin. The procedure as modified here can now be performed on patients of a wide variety of ages, skin types, genders, and ethnicities. Further, this procedure can be performed on patients with existing adequate “tooth show” who wish to improve upper lip height, character, and volume. Using the modified technique, even a conservative upper lip lift can significantly alter appearance and make the lip more receptive to filler augmentation. As described herein, defined mathematical relationships between marker(s) / marking(s) of marking system(s) provided herein provide a detectably or significantly improved control and precision in the procedure(s) in which they are applied, yielding detectably or significantly more reproducible and positive outcome(s) of such procedure(s).BRIEF DESCRIPTION OF THE DRAWINGS / FIGURES

[0023] The drawing(s) / figure(s) provided here, and the associated following brief description of figures are intended to exemplify certain aspect(s) and principle(s) of the disclosure without limiting its scope.

[0024] Figures 1 A, IB, and 1C each illustrate element(s) of a prior art marking system introduced by the present inventor. Figures 1 A, IB, and 1C are provided as black-and-white photographs.

[0025] Figures 2A, 2B, 2C, 2D, 2E, 2F, 2G, 2H, 21, 2J, 2K, 2L, and 2M provide exemplary marking(s) of marking system(s) of the present disclosure. Figure 2N provides an illustration identifying areas of the upper vermillion border for which particular slope(s) is / are generated according to one or more characteristic(s) of one or more marking(s) of marking system(s) of the present disclosure, such as defined characteristic(s) of the area to be excised.

[0026] Figure 20 provides an illustration identifying height differences between adjacent points along the upper vermillion border where marker(s) of marking system(s) disclosed herein meet the upper vermillion border.

[0027] Figures 3A and 3B illustrate a first embodiment of the marking system(s) of the present disclosure, identifying exemplary radial marking(s) thereof. Figure 3A is provided as a line-drawn version of the black and white photograph provided in Figure 3B.

[0028] Figure 4 illustrates a second embodiment of the marking system(s) of the present disclosure, identifying exemplary length(s) of various radial marking(s) thereof.

[0029] Figure 5 illustrates one embodiment of comer lift marking(s) provided in one embodiment of the marking system(s) of the present disclosure.

[0030] Figure 6 illustrates one embodiment of comer lift marking(s) provided in one embodiment of the marking system(s) of the present disclosure.

[0031] Figure 7 illustrates an embodiment of marking system(s) provided by the disclosure comprising application / consideration of mathematical analysis in the establishment of the length(s) of radial marker(s) or segment(s) thereof.

[0032] Figures 8A and 8B provide before photographs of a patient having received lip fillers (front (8A) and slight profile (8B) views).

[0033] Figures 9A and 9B provide photographs of the same patient shown in Figures 8A and 8B resulting from a classically designed, uniform excision deep plane lip lift (front (9A) and slight profile (9B) views).

[0034] Figures 10A and 10B provide photographs of the same patient shown in Figures 8 A, 8B, 9 A, and 9B resulting from the application of procedure(s) comprising the marking system(s) provided by the present disclosure (front (10A) and slight profile (10B) views).

[0035] Figure 11 provides a view of a marked-tip adjustable spacing device provided by the disclosure herein.

[0036] Figure 12 provides an alternative view of a marked-tip adjustable spacing device provided by disclosure herein.

[0037] Figure 13 provides yet another alternative view of a marked-tip adjustable spacing device provided by the disclosure herein.

[0038] Figure 14A provides an exemplary marking tip of marked-tip adjustable spacing device(s) provided by the disclosure herein.

[0039] Figure 14B provides an exemplary marking tip of the marked-tip adjustable spacing device(s) provided by the disclosure herein (shown only on the tip of the marked-tip adjustable spacing device).

[0040] Figure 14C provides an exemplary marking end of frame elements of marked-tip adjustable spacing device(s) provided by the disclosure herein.

[0041] Figure 14D provides an exemplary perspective of marked-tip adjustable spacing device(s) provided by the disclosure herein.

[0042] Figure 15 A provides an exemplary colorant container comprising colorant provided by the disclosure herein.

[0043] Figure 15B provides an exemplary colorant container comprising a matrix for maintaining colorant provided by the disclosure herein.

[0044] Figure 16 provides an exemplary use flow of an exemplary automated system in the form of a mobile application capable of generating marking system(s) or characteristic(s) thereof described herein.

[0045] Figure 17 provides an exemplary method of achieving a target aesthetic result comprising the use of automated system(s) capable of generating marking system(s) or characteristic(s) thereof described herein.

[0046] Figure 18 provides an exemplary method of achieving a target aesthetic result comprising the use of an automated system(s) capable of generating marking system(S) or characteristic(s) thereof described herein.

[0047] Figure 19 provides an embodiment of feature(s) and function(s) which may be present in automated system(s) provided by this disclosure.

[0048] Figure 20 provides an embodiment of a process of querying automated system(s) provided by this disclosure to retrieve data saved by such system(s).

[0049] Figure 21 provides an example of the application of landmark recognition technology to an image and the ability to modify predicted outcome(s) to generate one or more morphed image(s) within the automated system(s) provided by this disclosure.

[0050] Figure 22 provides an example of comparison tool(s) provided in embodiment(s) of automated system(s) described herein.

[0051] Figure 23 is a flow chart of an exemplary method according to the disclosure.

[0052] Figure 24 is a flow chart of a variation of the method of Fig. 23.

[0053] Figure 25 is a flow chart of steps of a method in which a user can perform an analysis for two or more proposed surgical procedures.

[0054] Figure 26 is a flow chart of a variation of the steps / sub-method shown in Fig. 25, in which the method / sub-method includes the use of artificial intelligence models for evaluating the performance of certain steps of the method.

[0055] Figure 27 provides a flow chart of further steps that can be performed to the methods of Figs. 23 or 24, in which a medical professional peforms a plastic surgery technique based on the output of the other steps of the method.

[0056] Figure 28 provides a schematic / map of an exemplary system of the disclosure.EXEMPLARY ASPECTS OF THE INVENTION

[0057] Disclosed here are several different but related exemplary aspects (variations) of systems, methods, and other disclosed subject matter provided in this disclosure that can be used to characterize claimed / claimable inventions. The following is a non-limiting list of exemplary aspects of the disclosure, which illustrates embodiments of the disclosure in a summary form to aid readers in quickly understanding the overall scope of the disclosure. Similar to patent claims, listed aspects described in the paragraphs of this section may make reference to (depend on / from) one or more other paragraphs. Readers will understand that such references mean that the features / characteristics or steps of such referenced aspects are incorporated into / combined with the referring aspect. For example, if an aspect in a paragraph (e.g., a paragraph indicated by text at the end of the paragraph as aspect 2) refers to another aspect by one or more aspect numbers (e.g., aspect 1 or "any one of aspects 1-3"), it will be understood to include the elements, steps, or characteristics of such referenced aspects (e.g., aspect 1) in addition to those of the aspect in which the reference is made (e.g., if aspect 2 refers to aspect 1, it provides a description of a composition, method, system, device, etc., including the features of both aspect 1 and aspect 2).

[0058] Lists of aspects describing specific exemplary embodiments of the disclosure are sometimes employed to aid the reader in understanding the disclosure. Such aspects can, within them, reference other exemplary aspects, either individually or as groups of aspects (e.g., via reference to a range within a list of numbered aspects when such aspects are provided as a numbered list). Reference to ranges of aspects should be interpreted as referencing all such aspects individually, each as unique embodiments of the disclosure, and in combination with one another as unique embodiment(s) of the disclosure, according to the presentation provided of such aspects unless such an aspect within such a referenced range is either contradictory or nonsensical. If contradicted, reference to the contradictory aspect should be excluded.

[0059] It is intended that these listed exemplary aspects begin with the first listed aspect (ASPECT 1) (or aspect 1) and thereafter be numbered sequentially and incrementally by the inclusion of a reference placed near or at the end of the listed aspect (ASPECT 2, ASPECT, 3, etc.). In case of a missing aspect reference or repeated aspect reference, the order of placement of the actual recited aspect in the list that is associated with the repeated aspect reference or missing aspect reference will control (e.g., if there is an unlabeled aspect located between a first aspect labeled ASPECT 1 and a third aspect labeled ASPECT 2, the unlabeled aspect should be treated as ASPECT 2, and the aspect labeled as ASPECT 2 treated as ASPECT 3, etc.), and all numbering in the list (including all references to aspects in the list) be interpreted as accordingly modified (e.g., if the fourth aspect in such list was labeled as ASPECT 3, it should be interpreted as being labeled as ASPECT 4, and if such aspect referred to “any one or both of aspect 1 or aspect 2,” it should be read as referring to “any one or more of aspects 1-3”). Similarly, if an aspect is misnumbered (e.g., by a number in the sequence being skipped or otherwise missing), readers will similarly construe this list of aspects according to the order of placement of the recited aspects, over the numerical references. Further, if one or more of the listed exemplary aspects of the disclosure in this section fails to reference any other aspects of the disclosure, such aspect, uncontradicted, should be interpreted as applying to or as capable of being incorporated into, any one or more other exemplary aspect(s) provided in this section.Marking System(s) and Related Method(s)

[0060] In aspects, the disclosure provides a marking system for use on a human subject in the preparation for, execution of, or both, an aesthetic modification of the upper lip by an upper lip lift procedure, the marking system comprising at least 7 radially spaced markings (markers) located between the nasal base which can in aspects be indicated by an upper excision boundary (002) and the upper vermillion border (020), each of the at least 7 radial markings comprising at least 3 different points within its length wherein the at least 3 different points within its length identify a first upper incision point along the nasal base (e.g., collectively defining an upper excision boundary (002)), a second lower incision point, and a third point located on the upper vermillion border (020), the at least 7 radial markings progressing from at least substantially vertical at the midline point of the Cupid’s bow trough with gradual radial rotation laterally towards the angle of the nasolabial fold(s) (016A) and (016B) (respectively), following the lip’s natural relaxed tension lines, pores, or both, wherein the at least 7 radially spaced markings (markers) comprise at least (1) a first radial marking (“radial marking 1” (labeled in figure(s) as (006)) positioned in the middle of the columella and philtral dimple, atthe lowest point of the trough of Cupid’s bow; (2) 2 radial markings (“radial marking 2A” (008A) and “radial marking 2B” (008B)) positioned lateral to and on either side of radial marking 1 (006), respectively, each located lateral to the columella at the peaks of Cupid’s bow and at the point where the medial crural footplates diverge into the nose at the junction with the alar sill; (3) 2 radial markings (“radial marking 3A” (010A) and “radial marking 3B” (010B)) positioned lateral to each of radial markings 2A (008A) and 2B (008B), respectively, such that the two radial markings 3A (010A) and 3B (010B) are positioned centrally between radial markings 2A (008A) and 4A (012A) and between radial markings 2B (008B) and 4B (012B), respectively; and (4) 2 radial markings (“radial marking 4A” (012A) and “radial marking 4B” (012B)) positioned lateral to each of radial markings 3A (010A) and 3B (010B), respectively, from the internal angle of the alar recurvature extending radially downward and following the natural curvature and natural tension lines, radial angulation of the pores of the upper lip, or combination thereof and wherein radial marking(s) 4A and 4B are at least substantially diagonal line(s), wherein all markings to a first lateral side of the first radial marking (radial marking 1 (006)) are identifiable as a first group of markings (e.g., “group A markings”), and all markings to a second lateral side of the first radial marking are identifiable as a second group of markings (e.g., “group B markings”), and wherein a pre-determined target aesthetic shape of the upper lip, a target lope(s) of the upper vermillion of between about 1 and about 3 such as about 2, target tooth show, or combination(s) thereof, define a distance between the second lower incision point and the third point located on the upper vermillion border (020) along each of the at least 7 radial markings, and wherein the defined distance between the second and third points along each of the at least 7 radial markings defines a final height of the upper lip at the location of such marking (“final height portion” of such marking(s)), and further wherein the remaining distance along each of the at least 7 radial markings between the second point lower incision point and the first upper incision point define the excision height at the location of such marking (“excision height portion” of such marking(s)) identifies the shape of a region to be excised (001) in the upper lip lift procedure resulting in the target aesthetic appearance. (ASPECT 1.)

[0061] In aspects, the disclosure provides the marking system of aspect 1, wherein the marking system comprises a marking along the nasal base indicating the upper excision boundary (002) and comprising the upper incision point of each of the radial markings, the upper excision boundary (002) following at least substantially horizontally along the subnasal, perialar crease. (ASPECT 2.)

[0062] In aspects, the disclosure provides the marking system of aspect 2, wherein the upper excision boundary marking (002) comprises two peaks on either side of the midline at the divergence of the medial crural footplate and the nasal sill. (ASPECT 3).

[0063] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 3, wherein the marking system comprises a mid-line marking identifiable as the lower excision boundary (004) between the nasal sill and the upper vermillion border (020) and comprising the lower incision point of each of the radial markings and wherein the mid-line marking is not established prior to establishing the target final height of the upper lip along each of the at least 7 radial markings. (ASPECT 4.)

[0064] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 4, wherein the marking system comprises two or more markings delineating at least a first defined region of the upper lip from at least a second defined region of the upper lip, wherein the at least first and second defined regions of the upper lip differ from one another in their sensitivity to the lift effect of an upper lip lift procedure. (ASPECT 5.)

[0065] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 5, wherein radial markings 4A (012 A) and 4B (012B) each respectively determine the lateral extent of the lift effect on the upper lip caused by the upper lip lift. (ASPECT 6.)

[0066] In aspects, the disclosure provides the marking system of any one or both of aspect 5 and aspect 6, wherein radial markings 4A (012A) and 4B (012B) delineate the at least first defined region of the upper lip from the at least second defined region of the upper lip, and wherein the at least first and second defined regions of the upper lip differ from one another in their sensitivity to the lift effect of an upper lip lift procedure. (ASPECT 7.)

[0067] In aspects, the disclosure provides the marking system of any one or more of aspects 5 - 7, wherein the at least first defined region of the upper lip is the region of the lip which is delectably or significantly more densely attached to the pyriform than the at least second defined region and is detectably or significantly supported by the subject’s front teeth (“subnasal lip”). (ASPECT 8.)

[0068] In aspects, the disclosure provides the marking system of any one or all of aspects 5 - 8, wherein an at least second defined region of the upper lip is the region of the lip which hangs from the anterior cheek and face (“subfacial lip & lateral mouth”). (ASPECT 9.)

[0069] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 9, wherein radial markings 4A (012 A) and 4B (012B) each respectively mark theborder between a first region of the upper lip identified as the subnasal lip as it transitions to a second region of the upper lip identified as the subfacial lip & lateral mouth. (ASPECT 10.)

[0070] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 10, wherein the marking system provides identification of an at least first defined region of the upper lip (“subnasal lip”) and an at least second defined region of the upper lip (“subfacial lip & lateral mouth”) delineated by radial markings 4A (012A) and 4B (012B), wherein the location of other radial marking(s) within a defined region indicates the degree of the effect of the subnasal lip lift at the location of such radial marking(s). (ASPECT 11.)

[0071] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 11, wherein a subnasal lip region and subfacial lip & lateral mouth regions are demarcated by the 2 bilateral radial markings 4A (012A) and 4B (012B), the subnasal lip region being located between or medial to radial markings 4 A (012 A) and 4B (012B) and the subfacial lip & lateral mouth regions being located lateral to each of radial markings 4A (012 A) and 4B (012B), respectively. (ASPECT 12).

[0072] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 12, wherein the marking system identifies at least 7 independent target locations for modification of the upper lip lift such that each of the at least 7 independent target locations can be independently modified to attain one or more target aesthetic effect(s). (ASPECT 13.)

[0073] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 13, wherein the marking system is a guide for use before, during, or both before and during an upper lip lift procedure and establishes lip shape resulting from the upper lip lift procedure. (ASPECT 14.)

[0074] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 14, wherein the length of the portion of (segment of) one or more radial markings representing the final height of the upper lip, the length of the portion of (segment of) one or more radial markings representing the excision height, or a combination thereof establishes the lip shape resulting from the upper lip lift procedure. (ASPECT 15.)

[0075] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 15, wherein the length of the portion of (segment of) one or more radial markings representing the final height of the upper lip, the length of the portion of (segment of) one or more radial markings representing the excision height, or a combination thereof establishes the shape of the upper vermillion resulting from the upper lip lift procedure. (ASPECT 16.)

[0076] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 16, wherein the length of the portion of (segment of) one or more radial markings representing the final height of the upper lip, the length of the portion of (segment of) one or more radial markings representing the excision height, or a combination thereof establishes the slope of the upper vermillion border (020) resulting from the upper lip lift procedure, wherein the slope of the upper vermillion border (020) is the vertical descent of the upper vermillion border (020) from the Cupid’s peak following laterally toward the oral commissure when viewing the human subject face-on. (ASPECT 17.)

[0077] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 17, wherein the marking system establishes a slope of the upper vermillion border (020) yielding an about 1 mm to an about 3 mm height difference between points along the vermillion border (020) associated with radial markings 2A (008A) and 3 A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), and 3B (010B) and 4B (012B), respectively. (ASPECT 18.)

[0078] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 18, wherein the marking system establishes a slope of the upper vermillion border (020) yielding an about 2 mm height difference between points along the upper vermillion border (020) associated with radial markings 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), and 3B (010B) and 4B (012B), respectively. (ASPECT 19.)

[0079] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 19, wherein the length of the radial markings of the marking system establish a height differential between the trough of the subject’s Cupid’s bow and the peaks of the subject’s Cupid’s bow of between about 1 mm and about 3 mm; a height differential between the dip of the columella beneath the nose of the subject and the points where the medial crural footplates diverge into the nose at the junction with the alar sill of the subject of between about 1 mm and about 3 mm; or both a height differential between the trough of the Cupid’s bow and the peaks of Cupid’ s bow and a height differential between the dip of the columella beneath the nose and the points where the medial crural footplates diverge into the nose at the junction with the alar sill of about 1 mm to about 3 mm. (ASPECT 20.)

[0080] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 20, wherein the length of the radial markings of the marking system establish a height differential between the trough of the subject’s Cupid’s bow and the peaks of the subject’s Cupid’s bow of about 2 mm; a height differential between the dip of the columella beneath thenose of the subject and the points where the medial crural footplates diverge into the nose at the junction with the alar sill of the subject of about 2 mm; or both a height differential between the trough of the Cupid’s bow and the peaks of Cupid’s bow and a height differential between the dip of the columella beneath the nose and the points where the medial crural footplates diverge into the nose at the junction with the alar sill of about 2 mm. (ASPECT 21.)

[0081] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 21, wherein the portion of (segment of) the length of radial marking 1 (006) indicating the final height of the upper lip and the portions of (segments of) the lengths of markings 2A (008A) and 2B (008B) indicating the final height of the upper lip are at least essentially equal, and wherein the portion of (segment of) the length of radial marking 1 (006) indicating the excision height and the portions of (segments of) the lengths of radial markings 2A (008A) and 2B (008B) indicating the excision heights are established by the location of the second lower excision point along the length of each of radial markings 1, 2A (008A), and 2B (008B). (ASPECT 22.)

[0082] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 22, wherein the portion of (segment of) the length of radial marking 1 (006) indicating the final height of the upper lip and the portions of (segments of) the lengths of radial markings 2A (008A) and 2B (008B) indicating the final height of the upper lip are at least essentially equal, and wherein the portion of (segment of) the length of radial marking 1 (006) indicating the final height of the upper lip and the portions of (segments of) the lengths of radial markings 2A (008A) and 2B (008B) indicating the final heights of the upper lip are established by the location of the second lower excision point along the length of each of the radial markings 1, 2A (008A), and 2B (008B). (ASPECT 23.)

[0083] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 23, wherein the portion of (segment of) one or more of radial markings 2A (008A), 3A (010A), 2B (008B), 3B (010B), 4A (012A), and 4B (012B) identifying the final height of the upper lip at the point of such radial markings provides a post-excision slope of the upper vermillion border (020) yielding a height differential of between about 1 mm and about 3 mm between the points on the upper vermillion border (020) established by 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), and 3B (010B) and 4B (012B), respectively. (ASPECT 24.)

[0084] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 24, wherein the portion of (segment of) one or more of radial markings 2A (008A),3A (010A), 2B (OO8B), 3B (O1OB), 4A (012A), and 4B (012B) identifying the final height of the upper lip at the point of such radial markings provides a post-excision slope of the upper vermillion border (020) yielding a height differential of about 2 mm between the points on the upper vermillion border (020) established by 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), and 3B (010B) and 4B (012B). (ASPECT 25.)

[0085] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 25, wherein lengths of the portion of (segments of) each radial marking of the marking system identifying the final height of the upper lip establish the excision height of a bull’s horn- shaped excision comprising the excision height portion of each radial markings. (ASPECT 26).

[0086] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 26, wherein the nasal base, upper lip, or both, of the human subject possess(es) one or more asymmetries and one or more radial markings of group A is different from one or more of the corresponding radial markings of group B to vary the excision height, e.g., vary the excision design of a bull’s horn-shaped excision, from side-to-side of the subject’s upper lip. (ASPECT 27.)

[0087] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 27, wherein the marking system comprises 2 additional (e.g., eighth and ninth) radial markings ( “radial marking 5A” (014A) and “radial marking 5B” (014B)) positioned lateral to each of radial markings 4A (012A) and 4B (012B), respectively, and each of radial marking 5A (014A) and radial marking 5B (0146) at least essentially follow the relaxed skin tension lines (RSTLs), extending downward from the apex of the lateral end of the upper excision to be made at the nasal base. (ASPECT 28.)

[0088] In aspects, the disclosure provides the marking system of aspect 28, wherein the marking system identifies at least 9 independent target locations for modification of the upper lip lift such that each of the at least 9 independent target locations can be independently modified to attain one or more target aesthetic effect(s), however wherein the sensitivity to modification at location(s) medial to at least one location is identified as being higher than modification at location(s) lateral to the at least one location identified by the marking system. (ASPECT 29.)

[0089] In aspects, the disclosure provides the marking system of any one or both of aspect 28 and aspect 29, wherein the sensitivity to modification at locations lateral to radial marking(s) 4A (012A) and 4B (012B) is higher than that at locations medial to radial marking(s) 4A (012A) and 4B (012B). (ASPECT 30.)

[0090] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 30, wherein the marking system comprises one or more horizontal lateral extension markings(s) (“lateral extension marking LE-A” (018 A) and “lateral extension marking LE-B” (018B)) as horizontal extension(s) of the point along radial line 4A (012A), 4B (012B), or both indicating the lower excision boundary marker (004) laterally toward radial marking 5A (014A), 5B (014B), or both. (ASPECT 31.)

[0091] In aspects, the disclosure provides the marking system of -aspect 31, wherein lateral extension marking LE-A (018A), lateral extension marking LE-B (018B), or both establish one or more locations applicable to the conduct of a corner lift procedure performed on the subject in addition to, e.g., concomitantly with, the upper lip lift procedure. (ASPECT 32.)

[0092] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 32, wherein an additional one or more radial markings (“intermedial radial markings”) are present between any two neighboring radial markings described in one or more of aspects 1 - 32, further dividing the space between any two markings described in one or more of aspects 1 - 32. (ASPECT 33.)

[0093] In aspects, the disclosure provides the marking system of aspect 33, wherein the additional one or more radial markings present between any two neighboring radial markings described in one or more of aspects 1 - 32 detectably or significantly increase(s) the level of control provided by the marking system to a practitioner for attaining targeted aesthetic design feature(s) resulting from the upper lip procedure. (ASPECT 34.)

[0094] In aspects, the disclosure provides the marking system of any one or both of aspect 33 and aspect 34, wherein the space between radial markings 1 (006) and 2A (008A), 1 (006) and 2B (008B), 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or any two or more thereof is / are divided approximately in half with an additional radial marking line, and wherein the target slope of the upper vermillion border (020) established by the marking system comprises an about 1 mm height difference between the point(s) of any new radial marking line along the upper vermillion border (020) and an immediately neighboring one or two of the points along the upper vermillion border (020) associated with radial markings 2A (008A), 3A (010A), 2B (008B), 3B (010B), 4A (012A), and 4B (012B). (ASPECT 35.)

[0095] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 35, wherein the marking system further comprises at least one independent marking used to facilitate a corner lip lift procedure accompanying the upper lift procedure (e.g.,performed concomitantly with the upper lip lift procedure), the at least one corner lip marking comprising either (1) an at least substantially elliptical or fusiform shape and ending laterally at the oral commissure (“Type I”), or (2) an enclosed shape extending past the commissure and comprising a detectably or significantly upward inflection (“Type II”), wherein Type I markings ((042A) or (042B) or both) are a guide in a corner lip procedure when exposure and lifting the lateral vermillion is to be performed, and wherein Type II markings ((044A) or (044B) or both) are a guide in a corner lip procedure when lifting the commissure, neutralizing down-pointing rhytids extending inferior to the chelion is to be performed, or when both lifting the commissure and neutralizing down-pointing rhytids extending inferior to the chelion are to be performed. (ASPECT 36.)

[0096] In aspects, the disclosure provides the marking system of aspect 36, wherein the point(s) on the upper vermillion border (020) of radial marking lines 4 A (012A) and 4B (012B), as applicable to the side(s) of the subject’s mouth undergoing the corner lip procedure, is / are used as a starting point for a straight horizontal marking line drawn laterally from such point(s) (“horizontal marking H-A” (046A) and “horizontal marking H-B” (046B), respectively) to establish a reference point for use in performing a corner lift incision. (ASPECT 37.)

[0097] In aspects, the disclosure provides the marking system of any one or both of aspect 36 and aspect 37, wherein the marking system comprises at least two additional, e.g., eighth and ninth, radial markings (“radial marking 5A” (014A) and “radial marking 5B” (014B)) positioned lateral to each of radial markings 4A (012A) and 4B (012B), respectively, wherein radial markings 5A (014A) and 5B (014B) follow the relaxed skin tension lines (RSTLs) and extend downward from the apex of the lateral end of the upper excision to be made at the nasal base, and wherein the second lower incision point along radial markings 4A (012A) and 5A (014A), along radial markings 4B (012B) and 5B (014B), or along 4A (012A), 5A (014A), 4B (012B), and 5B (014B) as applicable to the side(s) of the subject’s mouth undergoing the comer lip procedure are located such that the portion of (segment of) each of applicable radial markings 4A (012A) and 5A (014A), 4B (012B) and 5B (014B), or both representing the final lip height (segment of each marking between the second lower incision point and a third point located on the upper vermillion border (020)) are at least essentially equal. (ASPECT 38.)

[0098] In aspects, the disclosure provides the marking system of any one or both of aspects 36 - 38, wherein the marking system comprises at least two additional, e.g., eighth and ninth, radial markings (“radial marking 5A” (014A) and “radial marking 5B” (014B)) positioned lateral to each of radial markings 4A (012A) and 4B (012B), respectively, wherein radialmarkings 5A (014A) and 5B (OHB) follow the relaxed skin tension lines (RSTLs) and extend downward from the apex of the lateral end of the upper excision to be made at the nasal base, and wherein the length of the portions of (segments of) radial markings 4A (012A) and 5 A (014A) representing the excision height, the length of the portions of (segments of) radial markings 4B (012B) and 5B (0146) representing the excision height, or the length of the portions of (segments of) both radial markings 4A (012A) and 5A (014A) and 4B (012B) and 5B (014B) (as applicable to the side(s) of the subject’s mouth undergoing the corner lip procedure) representing the excision height are detectably or significantly different. (ASPECT 39.)

[0099] In aspects, the disclosure provides the marking system of any one or more of aspects 36 - 39, wherein radial markings 4A (012A) and 4B (012B) demarcate locations medial to which the corner lift procedure is initiated (as applicable to the side(s) of the subject’s mouth undergoing the corner lip procedure) to shorten the final lip height (portion of (segment of) each marking between the second lower incision point and a third point located along the upper vermillion border (020)) of radial marking(s) 4A (012A) and 4B (012B) (as applicable to the side(s) of the subject’s mouth undergoing the comer lip procedure). (ASPECT 40.)

[0100] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 40, wherein Pythagoras’ theorem a2+ b2= c2is considered in the determination of the appropriate length of the portion (segment) identified as excision height of one or more radial markings given a determined lateral distance between two points along the upper vermillion of two radial markers expected to result in a height difference between the points of at least two neighboring radial markings along the upper vermillion border (020) of between about 1mm and about 3 mm. (ASPECT 41.)

[0101] In aspects, the disclosure provides the marking system of aspect 41, wherein Pythagoras’ theorem a2+ b2= c2is considered in the determination of the appropriate length of the portion (segment) identified as excision height of one or more radial markings given a determined lateral distance between two points along the upper vermillion of two radial markers expected to result in a height difference between the points of at least two neighboring radial markings along the upper vermillion border (020) of about 2 mm. (ASPECT 42.)

[0102] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 42, wherein Pythagoras’ theorem a2+ b2= c2is considered in the determination of the appropriate length of the portion (segment) identified as excision height of one or more of radial markings 3A (010A), 4A (012A), 3B (010B), and 4B (012B) given a determined lateral distance between points along the upper vermillion of radial markers 1, 2A (008A), 2B (008B),3A (010A), 4A (012A), 3B (O1OB), and 4B (012B) as applicable, to result in a height difference between the points of 3A (010A) and 4A (012A) along the upper vermillion border (020), the height difference between the points of 3B (010B) and 4B (012B) along the upper vermillion border (020), or to result in a height difference between the points of 3A (010A) and 4A (012A) and 3B (010B) and 4B (012B), of between about 1mm and about 3 mm. (ASPECT 43.)

[0103] In aspects, the disclosure provides the marking system of aspect 43, wherein Pythagoras’ theorem a2+ b2= c2is considered in the determination of the appropriate length of the portion (segment) identified as excision height of one or more of radial markings 3A (010A), 4A (012A), 3B (010B), and 4B (012B) given a determined lateral distance between points along the upper vermillion of radial markers 1, 2A (008A), 2B (008B), 3A (010A), 4A (012A), 3B (010B), and 4B (012B) as applicable, to result in a height difference between the points of 3A (010A) and 4A (012A) along the upper vermillion border (020), the height difference between the points of 3B (010B) and 4B (012B) along the upper vermillion border (020), or to result in a height difference between the points of 3A (010A) and 4A (012A) and 3B (010B) and 4B (012B), of about 2 mm. (ASPECT 44.)

[0104] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 44, wherein the upper lip lift procedure is a deep plane release subnasal upper lip aesthetic modification procedure. (ASPECT 45.)

[0105] hi aspects, the disclosure provides the marking system of any one or more of aspects 1 - 45, wherein the upper lip lift procedure encompasses use of a bull’s horn surgical technique. (ASPECT 46.)

[0106] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 46, wherein one or more markings of the marking system is / are used in one or more procedures ancillary to the upper lip lift comprising comer lip lift(s), a nasal base suspension, a muscle suspension, or a combination of any or all thereof. (ASPECT 47.)

[0107] In aspects, the disclosure provides the marking system of any one or more of aspects 1 - 47, wherein, one or more markings of the marking system is / are a guide for an upper lip lift procedure and optionally one or more additional ancillary procedures comprising corner lip lift(s), nasal base suspension, muscle suspension, or a combination of any or all thereof. (ASPECT 48.)

[0108] In aspects, the disclosure provides a procedure for the aesthetic modification of the face of a human subject, the procedure comprising incorporation of the marking system of any one or more of aspects 1 - 48. (ASPECT 49.)

[0109] In aspects, the disclosure provides a method of aesthetically modifying the face of a human subject, the method comprising use of the marking system of any one or more of aspects 1 - 48. (ASPECT 50.)

[0110] In aspects, the disclosure provides an upper lip lift procedure, the procedure comprising incorporation of the marking system of any one or more of aspects 1 - 48. (ASPECT 49.)

[0111] In aspects, the disclosure provides a method of performing an upper lip lift procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48. (ASPECT 52.)

[0112] In aspects, the disclosure provides a deep plane release upper lip aesthetic modification procedure, the procedure comprising incorporation of the marking system of any one or more of aspects 1 - 48. (ASPECT 53.)

[0113] In aspects, the disclosure provides a method of performing a deep plane release upper lip aesthetic modification procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48. (ASPECT 54.)

[0114] In aspects, the disclosure provides a corner lip lift procedure comprising incorporation of one or more markings of the marking system of any one or more of aspects 1 - 48. (ASPECT 55.)

[0115] hi aspects, the disclosure provides a method of performing a corner lip lift procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48. (ASPECT 56.)

[0116] In aspects, the disclosure provides a nasal base suspension procedure comprising incorporation of one or more markings of the marking system of any one or more of aspects 1 - 48. (ASPECT 57.)

[0117] In aspects, the disclosure provides a method of performing a nasal base suspension procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48. (ASPECT 58.)

[0118] In aspects, the disclosure provides a muscle suspension procedure comprising incorporation of one or more markings of the marking system of any one or more of aspects 1 - 48. (ASPECT 59.)

[0119] In aspects, the disclosure provides a method of performing a muscle suspension procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48. (ASPECT 60.)

[0120] In aspects, the disclosure provides a method of (1) assessing the face of a human subject in preparation for aesthetic modification of the subject’s upper lip by application of an upper lip lift procedure to identify a target aesthetic appearance and (2) characterizing one or more surgical requirements required in the upper lip lift procedure such that the procedure results in a target aesthetic appearance, the method comprising (A) evaluating one or more features of the human subject’s face; (B) identifying a target aesthetic appearance; (C) identifying one or more surgical modifications required to be made in an upper lip lift procedure to achieve the target aesthetic appearance; and (D) establishing the marking system of any one or more of aspects 1 - 48 wherein the characteristic(s) of the marking system, when applied in the aesthetic modification, result in achieving the target aesthetic appearance. (ASPECT 61.)

[0121] In aspects, the disclosure provides a method of assessing a human subject in preparation for aesthetic modification of the upper lip and accordingly characterizing surgical requirements for an upper lip lift, the method comprising (1) marking the contour of the nasal base to establish a first generally horizontal indicator (“LEVEL 1 indicator”) (e.g., “upper excision boundary marker” (provided in the figures as (002)), wherein a third generally horizontal indicator (“LEVEL 3 indicator”) is formed by the upper vermillion border (020); (2) marking the anatomy of the upper lip of the human subject with at least 7 radially-spaced (radial) markings, wherein the at least 7 radial markings progress from at least substantially vertical at the midline point of the Cupid’s bow trough with gradual radial rotation laterally towards the angle of the nasolabial fold(s) (016 A) and (016B) (respectively), following the lip’s natural relaxed tension lines, pores, or both, and wherein the group of at least 7 radial markings comprise at least (a) a first radial marking (“radial marking 1” (006)) positioned in the middle of the columella and philtral dimple, at the lowest point of the trough of Cupid’s bow; (b) 2 radial markings (“radial marking 2A” (008A) and “radial marking 2B” (008B)) positioned lateral to and on either side of radial marking 1 (006), respectively, each located lateral to the columella, at the peaks of Cupid’s bow and at the point where the medial crural footplates diverge into the nose at the junction with the alar sill; (c) 2 radial markings (“radial marking 4A” (012A) and “radial marking 4B” (012B)) positioned lateral to each of radial markings 3A (010A) and 3B (010B), respectively, each following the natural tension lines, radial angulation of the pores of the upper lip, or both;; and (d) 2 radial markings (“radial marking 3A” (010A) and “radial marking 3B” (010B)) positioned lateral to each of radial markings 2A (008A) and 2B (008B), respectively, such that the two radial markings 3A (010A) and 3B (010B) are positioned centrally between radial markings 2A (008A) and 4A (012A) and between radial markings 2B(008B) and 4B (012B), respectively, each of the at least 7 radial indicators comprising a discrete anatomical location along the nasal base, e.g., collectively forming a marking in aspects identified as an upper excision boundary (002) (LEVEL 1 indicator) and a corresponding discrete anatomical location along the upper vermillion border (020) (LEVEL 3 indicator); and wherein if each first and second discrete anatomical locations along the LEVEL 1 and LEVEL 3 indicators associated with each of the at least 7 radial markings 1, 2A (008 A), 2B (008B), 3 A (010A), 3B (010B), 4A (012A), and 4B (012B), respectively were to be connected, each of the resulting 7 connecting lines would intersect with the LEVEL 1 indicator, LEVEL 3 indicator, and a second generally horizontal indicator (“LEVEL 2 indicator”) (e.g., “lower excision boundary marker” (004)) positioned between the LEVEL 1 and LEVEL 3 indicators, and further wherein the distance between the LEVEL 1 and LEVEL 2 indicators along each of the radial markings establishes an excision height at the location of the radial marking and the distance between the LEVEL 2 and LEVEL 3 indicators along each of the radial markings establishes a final upper lip height at the location of the radial marking; (3) evaluating one or more anatomical features of the human subject to establish a target aesthetic appearance, e.g., to establish target aesthetic effect(s);(4) establishing the location along the path of each of the at least 7 connecting (present or virtual) lines where the LEVEL 2 indicator is positioned to achieve the target aesthetic appearance and positioning the same, such that when the area between the LEVEL 1 and LEVEL 2 indicators is excised in the lip lift procedure, the result is an at least essentially uniform slope or difference in height between the discrete anatomical locations along the upper vermillion border (020) of / between radial markings 2A (008A) and 3A (010A); 2B (008B) and 3B (010B); 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or any combination thereof. (ASPECT 62.)

[0122] In aspects, the disclosure provides the method of aspect 62, wherein the at least substantially uniform difference in height between the discrete anatomical locations along the upper vermillion border (020) of 2A (008A) and 3A (010A); 2B (008B) and 3B (010B); 3A (010A) and 4A (012A); 3B (010B) and 4B (012B); or combination thereof is between about 1 mm to about 3 mm. (ASPECT 63.)

[0123] In aspects, the disclosure provides the method of aspect 63, wherein the at least substantially uniform difference in height between the discrete anatomical locations along the upper vermillion border (020) of 2A (008A) and 3A (010A); 2B (008B) and 3B (010B); 3A (010A) and 4A (012A); 3B (010B) and 4B (012B); or combination thereof is about 2 mm. (ASPECT 64.)

[0124] In aspects, the disclosure provides the method of any one or more of aspects 61 -64, wherein the method comprises consideration of the lateral spacing along the upper vermillion border (020) between at least two radial markings and the application of Pythagoras’ theorem a2+ b2= c2to determine the appropriate excision height at the location of at least one radial marking required to attain an at least essentially constant about 1 mm to about 3 mm height difference between the discrete anatomical locations along the upper vermillion border (020) of two neighboring radial markings. (ASPECT 65.)

[0125] In aspects, the disclosure provides the method of any one or more of aspects 61 -65, wherein the method comprises consideration of the lateral spacing along the upper vermillion border (020) between at least two radial markings and the application of Pythagoras’ theorem a2+ b2= c2to determine the appropriate excision height at the location of at least one of the radial markings required to attain an at least essentially constant about 2 mm height difference between the discrete anatomical locations along the upper vermillion border (020) of two neighboring radial markings. (ASPECT 66.)

[0126] In aspects, the disclosure provides the method of any one or both of aspect 65 and aspect 66, wherein the method comprises the consideration of the lateral spacing along the upper vermillion border (020) between radial marking 4A (012A) and at least one other radial marking, between radial marking 4B (012B) and at least one other radial marking, or both. (ASPECT 67.)

[0127] In aspects, the disclosure provides the method of any one or more of aspects 61 -67, wherein the upper / superior end of radial markings 2 A (008 A) and 2B (008B) identify the upper / superior peak of the subnasal incision to be made in the upper lip lift procedure. (ASPECT68.)

[0128] In aspects, the disclosure provides the method of any one or more of aspects 61 - 68, wherein one or more additional (e.g., intermediary) radial markings (indicators) is / are added between any two or more of radial markings (indicators) 1 and 2A (008A), 1 and 2B (008B), 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or is / are added lateral to 4A (012A), 4B, or both, and where in the additional (intermediary) radial indicator(s) provide a mechanism for a detectable or significant amount of additional control in establishing the at least essentially similar difference in height between the discrete anatomical locations along the upper vermillion border (020) of radial markers 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or any combination thereof. (ASPECT 69.)

[0129] In aspects, the disclosure provides the method of aspect 69, wherein the additional (intermediary) radial indicator(s) are positioned between radial markers (indicators) 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or in any two or more such locations, and wherein the difference in height between the discrete anatomical locations along the upper vermillion border (020) of the additional radial indicator(s) and any adjacent radial indicator(s) is about 1 mm. (ASPECT 70.)

[0130] In aspects, the disclosure provides the method of any one or more of aspects 61 -70, wherein the excision height within a radial marker on one lateral side of radial marker 1 (006) is detectably or significantly different than the excision height within the corresponding radial marker on the opposite lateral side of radial marker 1 (006), but wherein the final lip height within the radial marker on the one lateral side of radial marker 1 (006) is at least essentially the same as the final lip height within the corresponding radial marker on the opposite lateral side of radial marker 1 (006). (ASPECT 71.)

[0131] In aspects, the disclosure provides the method of any one or more of aspects 61 -71, wherein the at least essentially uniform difference in height between the discrete anatomical locations along the upper vermillion border (020) of radial markers 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or any combination thereof is a height difference of between about 1 mm and about 3 mm. (ASPECT72,)

[0132] In aspects, the disclosure provides the method of any one or more of aspects 61 -72, wherein the at least essentially uniform difference in height between the discrete anatomical locations along the upper vermillion border (020) of radial markings 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or any combination thereof is a height difference of about 2 mm. (ASPECT 73.)

[0133] In aspects, the disclosure provides the method of any one or more of aspects 61 -73, wherein the method further comprises evaluating the points of termination along the upper vermillion of radial markings 4 A (012A) and 4B (012B) and the shape of the subfacial cheek lip and cheek lateral thereto, respectively, and determining whether the lateral lip slope requires adjustment by a comer lift procedure to maintain the slope of the upper vermillion targeted between the points along the upper vermillion of radial markers 2A (008A) and 3 A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), and 3B (010B) and 4B (012B), or combinations thereof established in / by the method, the slope being represented by the at least essentially uniform height difference between the points along the upper vermillion of radialmarkers 2A (008A) and 3A (010A), 2B (OO8B) and 3B (O1OB), 3A (O1OA) and 4A (012A), and 3B (O1OB) and 4B (012B). (ASPECT 74.)

[0134] In aspects, the disclosure provides the method of any one or more of aspects 61 - 74, wherein 2 additional radial markings (“radial marking 5A” (014A) and “radial marking 5B” (014B)) are established and positioned lateral to each of radial markings 4A (012A) and 4B (012B), respectively, following each of the relaxed skin tension lines (RSTLs), extending downward from the apex of the lateral end of the upper excision to be made at the nasal base (upper excision boundary (002)) on either side of the upper lip. (ASPECT 75.)

[0135] In aspects, the disclosure provides the method of aspect 75, wherein the application of the method results in the at least essentially uniform difference in height between the discrete anatomical locations along the upper vermillion border (020) of radial markers 2A (008A) and 3A (010A); 2B (008B) and 3B (010B); 3A (010A) and 4A (012A); 3B (010B) and 4B (012B); 4A (012A) and 5A (014A); 4B (012B) and 5B (014B); or any combination thereof is a height difference of between about 1 mm and about 3 mm, such as about 2 mm. (ASPECT 76.)

[0136] In aspects, the disclosure provides the method of any one or more of aspects 61 - 76, wherein two additional markings, “lateral extension marking LE-A” (018A) and “lateral extension marking LE-B” (018B), are established as horizonal extension(s) of the point along radial line 4A (012A), 4B (012B), or both indicating the lower excision boundary marker (004) laterally toward radial marking 5 A (014A), 5B (014B), or both, establishing one or more locations applicable to the conduct of a corner lift procedure performed on the subject in addition to, e.g., concomitantly with, the upper lip lift procedure. (ASPECT 77.)

[0137] In aspects, the disclosure provides the method of aspect 77, wherein lateral extension marking(s) LE-A (018 A), LE-B (018B), or both, are used in the conduct of a corner lip lift procedure. (ASPECT 78.)

[0138] In aspects, the disclosure provides the method of one or both of aspect 76 and aspect 77, wherein lateral extension marking(s) LE-A (018A), LE-B (081B), or both are used to remind a practitioner to place lateral internal mattress sutures during the upper lip lift procedure. (ASPECT 79.)

[0139] In aspects, the disclosure provides the method of any one or more of aspects 61 - 79, wherein the method is applied in one or more surgical technique(s) wherein the alar sill and nasal base are maintained in an intact anatomic subunit and not significantly crossed or violated. (ASPECT 80.)

[0140] In aspects, the disclosure provides the method of any one or more of aspects 61 -80, wherein the method further comprises use of preoperative photography to aid in the assessment of any requirement for asymmetric excision to be utilized in the upper lip lift procedure and optionally one or more ancillary procedure(s) performed in association with the upper lip lift procedure. (ASPECT 81.)

[0141] In aspects, the disclosure provides the method of any one or more of aspects 61 -81, wherein the method further comprises viewing the profile view of the subject for slope and projection as step(s) used in establishing the target aesthetic appearance and characterization of one or more surgical requirement(s) required to attain the target aesthetic appearance (e.g., target aesthetic effect(s)). (ASPECT 82.)

[0142] In aspects, the disclosure provides the method of any one or more of aspects 61 -82, wherein the final upper lip height indicated by any one or more of the radial marking(s) is at least about 10 mm. (ASPECT 83.)

[0143] In aspects, the disclosure provides the method of any one or more of aspects 61 -83, wherein the final upper lip height indicated by any one or more of the radial marking(s) is at least about 11 mm. (ASPECT 84.)

[0144] In aspects, the disclosure provides the method of any one or more of aspects 61 -84, wherein the method comprises the identification of at least two radial markings demarcating a first defined region identifiable as the subnasal lip region having a detectably or significantly greater sensitivity to an upper lip lift technique from a second defined region (e.g., a second region comprising two portions, the two portions divided by the subnasal lip region) each portion of the second defined region identifiable as the subfacial lip region(s)and having a detectable or significantly decreased sensitivity to an upper lip lift technique, wherein the upper lip lift technique is accordingly modified at the location of one or more other radial marker(s) according to the position of the other radial marker(s) relative to each of the two defined region(s) and, accordingly, the respective sensitivity(ies) to upper lip lift technique(s) at such radial marker location(s). (ASPECT 85).

[0145] In aspects, the disclosure provides the method of any one or more of aspects 61 -85, wherein the method provides the ability to detectably or significantly control, e.g., detectably or significantly predict, or detectably or significantly consistently attain, targeted lip shape during and resulting from the upper lip lift procedure or from multiple upper lip lift procedures when a plurality of procedure(s) is performed in accordance with the method. (ASPECT 86.)

[0146] In aspects, the disclosure provides the method of any one or more of aspects 61 -86, wherein the method results in the establishment of a guide for use before, during, or both before and during an upper lip lift procedure and wherein the guide serves to establish the shape of the upper vermillion resulting from the upper lip lift procedure. (ASPECT 87.)

[0147] In aspects, the disclosure provides the method of any one or more of aspects 61 -87, wherein the application of the method in an upper lip lift procedure results in the ability to detectably or significantly control the shape of the upper vermillion resulting from the upper lip lift procedure. (ASPECT 88.)

[0148] In aspects, the disclosure provides the method of any one or more of aspects 61 -88, wherein the conduct of the method results in the establishment of a guide for use before, during, or both before and during an upper lip lift procedure and wherein the guide serves to establish the slope of the upper vermillion border (020) resulting from the upper lip lift procedure, wherein the slope of the upper vermillion border (020) is the vertical descent of the upper vermillion border (020) from the Cupid’s peak following laterally toward the oral commissure when viewing the human subject face-on. (ASPECT 89.)

[0149] In aspects, the disclosure provides the method of any one or more of aspects 61 -89, wherein the application of the method in an upper lip lift procedure results in the ability to control the slope of the upper vermillion border (020) resulting from the upper lip lift procedure, wherein the slope of the upper vermillion border (020) is the vertical descent of the upper vermillion border (020) from the Cupid’ s peak following laterally toward the oral commissure when viewing the human subject face-on. (ASPECT 90.)

[0150] In aspects, the disclosure provides the method of any one or more of aspects 61 -90, wherein the method comprises the use of two or more markings of the marking system identifying two or more regions of the upper lip differing in their sensitivity to the effect of an upper lip lift procedure to achieve a target slope of the upper vermillion border (020) such that each of the at least two regions is independently considered and modified according to their sensitivity to the upper lip lift procedure, and wherein the slope of the upper vermillion border (020) is the vertical descent of the upper vermillion border (020) from the Cupid’s peak following laterally toward the oral commissure when viewing the human subject face-on.(ASPECT 91.)

[0151] In aspects, the disclosure provides the method of any one or more of aspects 61 -91, wherein the nasal base, upper lip, or both, of the human subject possess(es) one or more asymmetry(ies), and one or more radial marking(s) on a first side of the first radial marking(“Group A” markings) comprise(s) a different total length at a specific location which is different from the total length of the corresponding radial marking(s) located on a second side of the first radial marking (corresponding “Group B” marking(s)) and wherein the method provides identification of an excision height which varies from side-to-side of the subject’s upper lip at the two corresponding locations resulting in a final lip height at the two corresponding locations which is at least substantially or at least essentially the same. (ASPECT 92.)

[0152] In aspects, the disclosure provides the method of any one or more of aspects 61 -92, wherein the application of the method in a population of patients having an upper lip lift procedure incorporating the method detectably or significantly reduces the frequency of an undesirable exaggerated appearance compared to the frequency of an undesirable exaggerated appearance resulting in a population of patients having an upper lip lift procedure not incorporating the method as determined by the professional(s) performing the procedure(s), the subject(s) undergoing the procedure(s), a group of medical professionals trained in the art tasked with assessing the outcome of the procedure(s), one or more proactive or retroactive studies performed by or overseen by one or more skilled professionals in art or any combination of any or all thereof. (ASPECT 93.)

[0153] In aspects, the disclosure provides the method of any one or more of aspects 61 -93, wherein the application of the method results in a detectable or significant reduction in the frequency of an undesirable exaggeration in the slope of the upper vermillion border (020) yielding an unsatisfactory result in a population of patients having an upper lip lift procedure incorporating the use of the method compared to the frequency of an exaggeration in the slope of the upper vermillion border (020) yielding an unsatisfactory result in a population of patients having an upper lip lift procedure not incorporating the use of the method as determined by the professional(s) performing the procedure(s), the subject(s) undergoing the procedure(s), a group of medical professionals trained the art tasked with assessing the outcome of the procedure(s), one or more proactive or retroactive studies performed by or overseen by one or more skilled professionals in art, or any combination of any or all thereof. (ASPECT 94.)

[0154] In aspects, the disclosure provides the method of any one or more of aspects 61 -94, wherein the method comprises establishing an excision height segment length, a final height segment length, or both, of radial marking(s) 3A (010A), 3B (010B), or both yielding an application of a lift along radial marking(s) 3A (010A), 3B (010B), or both which is detectably or significantly lower relative to the lift along one or more other radial marking(s). (ASPECT95,)

[0155] In aspects, the disclosure provides the method of any one or more of aspects 61 - 95, wherein establishing an excision height segment length, a final height segment length, or both, of radial marking(s) 3A (010A), 3B (010B), or both to have length(s) yielding an application of a lift along them which is detectably or significantly less than the lift applied or present along one or more other radial marking(s) results in the upper lip lift procedure detectably or significantly relieving an appearance characterizable as angry, scowling, or snarled. (ASPECT 96.)

[0156] In aspects, the disclosure provides the method of any one or more of aspects 61 - 94, wherein establishing radial marking(s) 3 A (010A), 3B (010B), or both to have an excision height segment length(s), final lip height segment length(s), or both, yielding an application of a lift along them which is detectably or significantly greater relative to the lift applied or present along one or more other radial marking(s) results in the upper lip lift procedure detectably or significantly increasing or creating an appearance characterizable as angry, scowling, or snarled. (ASPECT 97.)

[0157] In aspects, the disclosure provides the method of any one or more of aspects 61 -97, wherein the application of the method in an upper lip lift procedure yields a lip design resulting from the upper lip lift procedure which detectably or significantly ages better than an upper lip lift procedure performed without the application of the method, wherein the degree of aging is assessed by measuring the relaxed skin tension lines (RSTLs) and the extent of drooping around the upper alveolus over time, measuring the degree of the subfacial lip(s) and lateral mouth hanging from the anterior cheek and face relative to the central subnasal lip more densely attached to the pyriform and supported by the front teeth over time, or both, and wherein such a result is determined by the professional(s) performing the procedure(s), the subject(s) undergoing the procedure(s), a group of medical professionals trained in the art tasked with assessing the outcome of the procedure(s), one or more proactive or retroactive studies performed by or overseen by one or more skilled professionals in the art, or any combination of any or all thereof over a period of time lasting from between about 5 years to about 70 years after the performance of the method. (ASPECT 98.)

[0158] In aspects, the disclosure provides the method of any one or more of aspects 61 -98, wherein the method establishes a guide yielding an incisor display of the human subject resulting from the upper lip lift procedure of between about 1 mm and about 8 mm. (ASPECT99,)

[0159] In aspects, the disclosure provides the method of any one or more of aspects 61 -99, wherein the method establishes a guide yielding an incisor display of the human subject resulting from the upper lip lift procedure of between about 1 mm and about 5 mm. (ASPECT100.)

[0160] In aspects, the disclosure provides the method of any one or more of aspects 61 -100, wherein the method establishes a guide yielding an incisor display of the human subject resulting from the upper lip lift procedure of less than 4 mm. (ASPECT 101.)

[0161] In aspects, the disclosure provides the method of any one or more of aspects 61 -101, wherein the method further comprises evaluating the subject for the need to perform a concomitant corner lip lift (e.g., to one or both corners of the mouth), neurotoxin injection(s) into depressor(s), volumization of a triangle inferior to the commissure, facelift, comer lip lift, nasal base suspension, muscle suspension, or a combination of any or all thereof, in order to attain a target aesthetic appearance established as a step of the method. (ASPECT 102.)

[0162] In aspects, the disclosure provides the method of aspect 102, wherein the method comprises establishing one or more parameters related to a concomitant comer lip lift, neurotoxin injection(s) into depressor(s), volumization of a triangle inferior to the commissure, facelift, comer lip lift, nasal base suspension, muscle suspension, or a combination of any or all thereof, as is determined required by the evaluation described in aspect 102. (ASPECT 103.)

[0163] In aspects, the disclosure provides the method of any one or more of aspects 61 -103, wherein the method further comprises marking at least one independent marking used to facilitate a corner lip lift procedure accompanying the upper lift procedure, the at least one comer lip marking comprising either (1) an at least substantially elliptical or fusiform shape and ending laterally at the oral commissure (“Type I”) ((042A) or (042B)), or (2) an enclosed shape extending past the commissure and comprising an upward inflection (“Type II”), wherein Type I markings (042A) or (042B) are used as a guide in a comer lip procedure to expose and lift the lateral vermillion, and wherein Type II markings ((044A) or (044B)) are used as a guide in a corner lip procedure to lift the commissure, neutralize down-pointing rhytids extending inferior to the chelion, or both lift the commissure and neutralize down-pointing rhytids extending inferior to the chelion, as determined is needed by the evaluation of the subject performed as a step in the method. (ASPECT 104.)

[0164] In aspects, the disclosure provides the method of any one or more of aspects 61 -104, wherein the point(s) on the upper vermillion border (020) of radial marking lines 4 A (012A) and 4B (012B), as applicable to the side(s) of the subject’s mouth determined to require a cornerlip procedure according to an evaluation performed (or as described) in aspect 102, is / are used as a starting point for marking at least substantially straight, at least substantially horizontal, or at least both substantially straight and horizontal marking line(s) drawn laterally from such point(s) toward radial marking lines 5A (014A) and 5B (014B), respectively (“horizontal marking H-A” (046A) and “horizontal marking H-B” (046B), respectively) wherein the, e.g., at least substantially straight and horizontal marking line(s) establish a reference point for use in a comer lift incision. (ASPECT 105.)

[0165] In aspects, the disclosure provides the method of any one or more of aspects 61 - 105, wherein the method comprises performing an ancillary corner lift procedure in addition to the upper lip lift procedure, and wherein the final upper lip height of radial markings 5A (014A), 5B (014B), or 5A (014A) and 5B (014B) (as applicable to the corner(s) of a / the mouth being lifted by a corner lift procedure) are established such that they are at least substantially similar to the final upper lip height of corresponding radial markings 4A (012A), 4B (012B), or 4A (012A) and 4B (012B) (as applicable to the comer(s) of a / the mouth being lifted by a comer lift procedure). (ASPECT 106.)

[0166] In aspects, the disclosure provides the method of any one or more of aspects 102- 106, wherein the method comprises performing an ancillary nasal base suspension procedure in addition to the upper lip lift procedure, and wherein the method comprises (1) use of the location of radial markings 4A (012A), 4B (012B), or both; (2) the degree of laxity of the lip at location(s) indicated by radial markings 3A (010A), 3B (010B), or both; or (3) both (1) and (2) in the nasal base suspension procedure to place one or more suture(s), select the path of at least one of the one or more suture(s), or both. (ASPECT 107.)

[0167] In aspects, the disclosure provides the method of any one or more of aspects 102- 107, wherein the method comprises performing an ancillary muscle suspension procedure in addition to the upper lip lift procedure, and wherein the method comprises use of the location of radial markings 1, 2A (008A), 2B (008B), 4A (012A), 4B (012B), or a combination thereof to identify the location of the placement of one or more sutures associated with the muscle suspension procedure. (ASPECT 108.)

[0168] In aspects, the disclosure provides the method of any one or more of aspects 61 -108, wherein the method further comprises evaluating the presence of lip filler(s). (ASPECT109.)

[0169] In aspects, the disclosure provides the method of aspect 109, wherein the method comprises dissolving at least generally all lip filler(s) present at least about 2 weeks before a liplift procedure performed in association with the method. (ASPECT 110.)

[0170] In aspects, the disclosure provides the method of any one or more of aspects 62 - 110, wherein the method comprises the use of a marking system having any one or more of the marking system characteristic(s) described in any one or more of aspects 1 - 48. (ASPECT 111.)

[0171] In aspects, the disclosure provides the method of any one or more of aspects 61 - 111 wherein the method is performed prior to the start of any excision performed as part of the upper lip lift procedure. (ASPECT 112.)

[0172] In aspects, the disclosure provides a method of marking a human face in preparation for a subnasal upper lip lift procedure and optionally one or more related procedures, the method comprising marking the human face with the marking system of any one or more of aspects 1 - 48. (ASPECT 113.)

[0173] In aspects, the disclosure provides a method of establishing a visual guide comprising a set of at least 7 markings on the face of a human subject for use in guiding a subnasal upper lip lift procedure and, optionally, one or more ancillary procedures comprising a corner lift procedure, nasal base suspension, muscle suspension, or any combination of any or all thereof, the method comprising (1) marking the upper boundary of a portion of the upper lip to be excised in the subnasal upper lip lift procedure, the upper boundary following horizontally along the subnasal, perialar crease, wherein the upper boundary of the portion of the upper lip to be excised comprises two peaks on either side of the midline at the divergence of the medial crural footplate and the nasal sill; (2) marking a central marking line (radial marking line 1 (006)) vertically down the middle of the philtral trough; (3) marking 2 paramedian lines (radial marking lines 2A (008A) and 2B (008B), on the first and second lateral sides of radial marking line 1 (006), respectively) along the subnasal perialar crease (e.g., the upper boundary), wherein each of the paramedial lines are on the first and second philtral columns, respectively; (4) marking 2 radial marking lines (radial marking lines 4A (012A) and 4B (012B), on the lateral sides of each of radial marking lines 2A (008A) and 2B (008B), respectively) along the subnasal perialar crease (e.g., the upper boundary), each demarcating the lateral extent of vertical lift effect of subnasal lip lift on the upper vermillion border (020); (5) marking a radial marking line between each of radial marking lines 2A (008A) and 4A (012A) and 2B (008B) and 4B (012B) (radial marking lines 3A (010A) and 3B (010B), respectively), along the subnasal perialar crease (e.g., the upper boundary) from the nasal sill and extending to the upper vermillion border (020);(6) determining one or more aesthetic result(s) to be achieved comprising, e.g., a visual balance of two or more facial features including the size of the upper lip to the nose, the size of the upper lip to the chin, the size of the upper lip to the remainder of the face, or a combination thereof; a target incisor display; a target final lip height; a target final philtral height; the accent (slope) and definition of the Cupid’s bow of the subject, the upper vermillion border (020) of the subject, or both; a target volume show of the subject’s red vermillion; a target height differential along the upper vermillion border (020) between two or more of radial markers 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), or a combination thereof; or any combination thereof; (7) determining the height of the excision across the portion of the upper lip to be excised in the subnasal upper lip lift procedure required to achieve the target aesthetic result(s); (8) marking the location between the nasal sill and the upper vermillion border (020) along the projected course of each of radial marking lines 1, 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), and 4B (012B) which indicates the lower excision boundary required to achieve the target aesthetic result(s) and which establishes a length between the given location and the point along the upper vermillion border (020) identified by the projected course of each of the radial marking lines 1, 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), and 4B (012B) representing the target final lip height at the location of that radial marking(s); (9) completing the remainder of each of the radial marking lines 1, 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), and 4B (012B) from the point of the lower excision boundary marker (004) to its corresponding point along the upper vermillion border (020); (10) optionally marking 2 radial markings (“radial marking 5A” (014A) and “radial marking 5B” (014B)) (which may be referred to herein as “Outer lines” or “O lines”) positioned lateral to each of radial markings 4A (012 A) and 4B (012B) respectively and following the RSTL extending downward from the apex of the upper boundary of the excision; and (11) optionally marking (a) one or more horizontal lateral line marking(s) (“horizontal marking H-A” (046A) and “horizontal marking H-B” (046B)) as horizontal extension(s) of the point along the upper vermillion border (020) of radial line 4A (012A), 4B (012B), or both, toward radial marking 5A (014A), 5B (014B), or both, respectively as applicable; (b) one or more horizontal lateral extension markings(s) (“lateral extension marking LE-A” (018 A) and “lateral extension marking LE-B” (018B)) as horizonal extension(s) of the point along radial line 4A (012A), 4B (012B), or both indicating the lower excision boundary marker (004) laterally toward radial marking 5A (014A), 5B (014B), or both; or (c) optionally marking both (a) and (b). (ASPECT 114.)

[0174] In aspects, the disclosure provides the method of aspect 114, wherein optional step (10), optional step (11), or both optional steps (10) and (11) are performed after the performance of a subnasal upper lip lift is performed using the guide established by steps (1) - (9) of the method. (ASPECT 115.)

[0175] In aspects, the disclosure provides the method of any one or more of aspects 113 - 115, wherein the upper boundary of the portion of the upper lip to be excised (upper excision boundary (002) does not extend beyond the natural ending of the subnasal, perialar crease. (ASPECT 116.)

[0176] In aspects, the disclosure provides the method of any one or more of aspects 113 - 116, wherein the upper boundary of the portion of the upper lip to be excised (upper excision boundary (002) ends where the vector of the marking becomes vertical. (ASPECT 117.)

[0177] In aspects, the disclosure provides the method of any one or more of aspects 113- 117, wherein the upper boundary of the portion of the upper lip to be excised (upper excision boundary (002) follows the border of the nasal skin and at least substantially avoids the mixture of nasal and labial skin via excision of nasal skin and transposition of lip skin into the nose during the subnasal upper lip lift procedure. (ASPECT 118.)

[0178] In aspects, the disclosure provides the method of any one or more of aspects 113 - 118, wherein radial marking line 1 (006) is made while holding the upper lip on gentle stretch. (ASPECT 119.)

[0179] In aspects, the disclosure provides the method of any one or more of aspects 113- 119, wherein one or more radial marking line(s), e.g., one or both of radial marking line(s) 2A (008A) and 2B (008B), are made with a marked-tip adjustable spacing device (MT-ASD) while gently stretching the lip. (ASPECT 120.)

[0180] In aspects, the disclosure provides the method of aspect 120, wherein the MT- ASD is specially designed for use in the method and comprises one or more of the characteristics of MT-ASDs described herein. (ASPECT 121.)

[0181] In aspects, the disclosure provides the method of any one or more of aspects 113 - 121, wherein if a target aesthetic effect is a detectable or significant improvement in the asymmetry of the philtral column height, markings of the guide are made by (1) measuring the residual height of a side of the philtral column identified as comprising a desirable height, and (2) applying the applicable marking to the contralateral side to establish the guide such that it yields the desired target symmetry without the placement of tension on the lip. (ASPECT 122.)

[0182] In aspects, the disclosure provides the method of any one or more of aspects 113- 122, wherein step (7) of the method comprises (1) consideration of the lateral spacing along the upper vermillion border (020) between two or more neighboring radial markings and (2) the application of Pythagoras’ theorem a2+ b2= c2to determine the appropriate length of the excision height of one or more radial marking lines given the lateral distance between the two or more neighboring radial markings required to attain a constant target slope of the upper vermillion border (020). (ASPECT 123.)

[0183] In aspects, the disclosure provides the method of aspect 123, wherein the target slope is established by a height difference between the points of the at least two neighboring radial markings along the upper vermillion border (020) of between about 1 mm and about 3 mm. (ASPECT 124.)

[0184] In aspects, the disclosure provides the method of any one or both of aspect 123 and aspect 124, wherein the target slope is established by a height difference between the points of the at least two neighboring radial markings along the upper vermillion border (020) of about 2 mm. (ASPECT 125.)

[0185] In aspects, the disclosure provides the method of any one or more of aspects 113- 125, wherein a target aesthetic effect is a targeted length of incisor display (“tooth show”), and wherein the targeted length of incisor display is between about 1 mm and about 3 mm. (ASPECT 126.)

[0186] In aspects, the disclosure provides the method of aspect 126, wherein the targeted length of the incisor display is about 2 mm. (ASPECT 127.)

[0187] In aspects, the disclosure provides the method of any one or more of aspects 113- 127, wherein the method is performed with the patient maintained in an upright position. (ASPECT 128.)

[0188] In aspects, the disclosure provides the method of any one or more of aspects 113- 128, wherein the method comprises assessing the vermillion body of the human subject for shape, previous scarring, volume, or any combination of any or all thereof prior to the application of any facial marking. (ASPECT 129.)Marked-Tip Adjustable Spacing Device (MT-AST)

[0189] In aspects, the disclosure provides a marked-tip adjustable spacing device (MT- ASD) (600) for use in marking human skin comprising a minimum marking distance and a maximum marking distance, the MT-ASD comprising(1) two frame elements (640), (655), each having at least approximately the same size and shape, wherein (a) the frame elements (640), (655) are movable relative to one another about a fixed point (680), and (b) the two frame elements (640), (655) exist in a device plane; (2) a marking end (650), (665) of each of the two frame elements (640), (655), respectively, wherein each marking end (650), (665) comprises a marking tip (685), (690), respectively, extending from each of the two marking ends (650) and (665) of the frame elements (640), (655), respectively, to form a pair of marking tips, wherein each marking tip (a) has a length (692); and (b) extends from each of the two frame elements (640), (655), respectively in a direction perpendicular to the device plane, and wherein (c) the pair of marking tips ((685), (690)) are positioned parallel to one another at all times and are in physical contact with one another across the entirety of their length when the MT-ASD (600) is established at its minimum marking distance position, and further wherein marking tip(s) (685), (690), or both are coated with, covered by, or are made of a non-metal colorant application material (695); or marking end(s) (650), (665), or both, and marking tip(s) (685), (690), or both are coated with, covered by, or are made of a non-metal colorant application material (695), wherein the non-metal colorant application material is capable of maintaining an effective amount of a colorant (710) such that when the colorant (710) is present on one or both of marking tip(s) (685) and (690), the MT-ASD (600) applies visible markings to human skin when the MT-ASD (600) is in use. (ASPECT 130.)

[0190] hi aspects, the disclosure provides the MT-ASD (600) of aspect 130, wherein the length of the device is no more than about 115 mm. ( ASPECT 131.)

[0191] In aspects, the disclosure provides the MT-ASD (600) of one or both of aspect 130 and aspect 131, wherein the maximum width of the device is no more than about 65 mm when the MT-ASD is set to its lowest possible marking distance. (ASPECT 132.)

[0192] In aspects, the disclosure provides the MT-ASD (600) of one or more of aspects 130-132, wherein the height of the device is no more than about 5 mm. (ASPECT 133.)

[0193] In aspects, the disclosure provides the MT-ASD (600) of one or more of aspects 130-133, wherein the maximum marking distance is a distance of no more than about 40 mm. (ASPECT 134.)

[0194] In aspects, the disclosure provides the MT-ASD (600) of one or more of aspects 130-134, wherein the minimum marking distance is zero mm. (ASPECT 135.)

[0195] In aspects, the disclosure provides the MT-ASD (600) of one or more of aspects 130-135, wherein the angle at which each of the marking tips (685), (690) extend from each of the two respective frame elements (640), (655) is no more than 90 degrees. (ASPECT 136.)

[0196] In aspects, the disclosure provides the MT-ASD (600) of one or more of aspects 130-136, wherein each of the marking tips (685), (690) extend at least substantially in the same, single direction, wherein the direction is a direction perpendicular to the device plane. (ASPECT 137.)

[0197] In aspects, the disclosure provides the MT-ASD (600) of one or more of aspects 130-137, wherein the nonmetal material is sufficiently flexible, soft, non-pointed, or combination(s) thereof so as to not delectably or significantly damage mammalian skin when the device is used to stretch the skin, apply a visible marking to the skin, or both. (ASPECT 138.)

[0198] In aspects, the disclosure provides the MT-ASD of any one or more of aspects 130 - 138, wherein the colorant is a non-permanent ink or dye. (ASPECT 139.)

[0199] In aspects, the disclosure provides the MT-ASD (600) of any one or more of aspects 130 - 139, wherein the MT-ASD is designed to apply one or more, such as two or more markings in a subnasal upper lip lift procedure. (ASPECT 140.)

[0200] In aspects, the disclosure provides the MT-ASD (600) of any one or more of aspects 130 - 140, wherein the MT-ASD is designed to mark paramedial (philtral) lines for reference in a subnasal upper lip lift procedure. (ASPECT 141.)

[0201] In aspects, the disclosure provides the MT-ASD (600) of any one or more of aspects 130 - 141, wherein the device is used to mark paramedial (philtral) lines for reference in a subnasal upper lip lift procedure while applying a detectable or significant stretch to the upper lip to which the paramedial (philtral) lines are applied. (ASPECT 142.)

[0202] In aspects, the disclosure provides a method of performing a subnasal upper lip lift procedure, the method comprising use of the MT-ASD (600) described in any one or more of aspects 130 - 142. (ASPECT 143.)

[0203] In aspects, the disclosure provides a method of aesthetically modifying the face of a human subject, the method comprising use of the marking system of one or more of aspects 1 - 48; incorporation of one or more of the procedure(s) or method(s) of aspects 49-129; use of the marking device of one or more of aspects 130-142; or a combination of any or all thereof.(ASPECT 144.)

[0204] In aspects, the disclosure provides a method of performing an upper lip lift procedure, e.g., a subnasal upper lip lift procedure, e.g., a subnasal and corner lip lift aesthetic modification procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48; incorporation of one or more of the procedure(s) or method(s) of aspects 49-129;use of the marking device of one or more of aspects 130-142; or a combination of any or all thereof. (ASPECT 145.)

[0205] In aspects, the disclosure provides a method of performing a deep plane release upper lip aesthetic modification procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48; incorporation of one or more of the procedure(s) or method(s) of aspects 49-129; use of the marking device of one or more of aspects 130-142; or a combination of any or all thereof. (ASPECT 146.)

[0206] In aspects, the disclosure provides a method of performing a comer lip lift procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48; incorporation of one or more of the procedure(s) or method(s) of aspects 49-129; use of the marking device of one or more of aspects 130-142; or a combination of any or all thereof. (ASPECT 147.)

[0207] In aspects, the disclosure provides a method of performing a nasal base suspension procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48; incorporation of one or more of the procedure(s) or method(s) of aspects 49-129; use of the marking device of one or more of aspects 130-142; or a combination of any or all thereof. (ASPECT 148.)

[0208] In aspects, the disclosure provides a method of performing a muscle suspension procedure, the method comprising use of the marking system of any one or more of aspects 1 - 48; incorporation of one or more of the procedure(s) or method(s) of aspects 49-129; use of the marking device of one or more of aspects 130-142; or a combination of any or all thereof. (ASPECT 149.)

[0209]

[0210]

[0211]

[0212] Automated System(s) and Related Method(s)

[0213] In aspects, the disclosure provides the procedure(s) and method(s) of any one or more of aspects -62-129, wherein the procedure(s) or method(s) comprise(s) the application of one or more automated system(s) comprising application of artificial intelligence to an image of the subject’s face to establish one or more feature(s) of one or more marking(s) of marking system(s) used in the method. (ASPECT 150.)

[0214] In aspects, the disclosure provides the procedure(s) and method(s) of any one or more of aspects 62 - 129, and 150, wherein the procedure(s) or method(s) comprise use of preoperative photography to aid in the assessment of any requirement for asymmetric excision to be utilized in the upper lip lift procedure and optionally one or more ancillary procedure(s) performed in association with the upper lip lift procedure. (ASPECT 151.)

[0215] In aspects, the disclosure provides marking system(s), procedure(s), and method(s), as appropriate, of one or more aspects of marking system(s), procedure(s), and method(s) provided herein, wherein computer-aided technology is applied such that one or more element(s) of marking system(s), one or more element(s) of procedure(s), or one or more element(s) of method(s), or any combination of any or all thereof, is / are performed in an at least partially computer-driven, automated manner. (ASPECT 152.)

[0216] In aspects, the disclosure provides marking system(s), procedure(s), and method(s), as appropriate, of one or more aspects of marking system(s), procedure(s), and method(s) provided herein, wherein (a) marking system(s) resulting in target aesthetic effect(s) when applied in procedure(s) and method(s) described herein, (b) procedure(s) and method(s) performed to achieve target aesthetic effect(s) described herein, or both (a) and (b) are established / performed utilizing artificial intelligence technology. (ASPECT 153.)

[0217] In aspects, the disclosure provides marking system(s), procedure(s), and method(s), as appropriate, of one or more aspects of marking system(s), procedure(s), and method(s) provided herein, wherein marking system(s) resulting in target aesthetic effect(s), or procedure^ ) and method(s) performed to achieve target aesthetic effect(s), are established utilizing landmark recognition technology, morphing technology, or both, wherein the use of landmark recognition technology, morphing technology, or both detectably or significantly improve(s) the predictability of result(s) / outcome(s) of aesthetic modification procedures comprising their incorporation. (ASPECT 153.)

[0218] In aspects, the disclosure provides an automated system for generating a plurality of measurements associated with at least 7 locations associated with the upper lip of a human face, the plurality of measurements being measurements which, when established by application of an upper lip lift aesthetic modification procedure to the human face, provide an aesthetic appearance predicted by the automated system, the automated system comprising (1) processing and memory functionality; (2) landmark detection functionality; (3) visual guide(s) generation, application, & measurement functionality(ies); (4) image morphing functionality; (5) artificial intelligence-based calculation capability; and (6) data capture and retrieval functionality, whereinthe automated system is designed to analyze an original image of at least the upper lip of a human face; apply landmark detection functionality to identify at least 7 specific locations on the image associated with dimensions of the upper lip of the human face; apply measurement functionality to the identified locations to obtain measurement(s) associated with the original image; morph the original image according to one or more input(s), rule(s), or setting(s) to establish a morphed image representing a target aesthetic appearance; and present to a user of the automated system data associated with modification(s) at one or more of the at least 7 specific location(s) required to be applied in the upper lip lift aesthetic modification procedure in order to obtain the target aesthetic appearance predicted by the morphed image. (ASPECT 154.)

[0219] In aspects, the disclosure provides the automated system of aspect 154, wherein the at least 7 specific locations comprise: (1) the middle of the columella and philtral dimple, at the lowest point of the trough of Cupid’ s bow and extending from the nasal base to the upper vermillion border (location 1, identified as “marker 1” of marking system(s) herein); (2) 2 lateral locations, one on either side of the columella at the peaks of Cupid’s bow and at the points where the medial crural footplates diverge into the nose at the junction(s) with the alar sill, each location extending from the nasal base to the upper vermillion border (locations 2 A and 2B, identified as “marker 2A” and “marker 2B” of marking system(s) herein); (3) 2 lateral locations, one on either side of the upper lip and each extending from the internal angle of the alar recurvature radially downward and following the natural curvature and natural tension lines, radial angulation of the pores of the upper lip, or any combination thereof, each location extending from the nasal base to the upper vermillion border (locations 4A and 4B, identified as “marker 4A” and “marker 4B” of marking system(s) herein); (4) 2 lateral locations, one in between each of the locations identified as location(s) (2) and (3) above on both sides of the upper lip, each location extending from the nasal base to the upper vermillion border (locations 3 A and 3B, identified as “marker 3 A” and “marker 3B” of marking system(s) herein. (ASPECT 155.)

[0220] In aspects, the disclosure provides the automated system of one or both of aspect 154 and 155, wherein the at least 7 specific locations further comprise locations positioned lateral to each of the positions identified as position (3) in aspect 147 above, on either side of the upper lip for a total of 2 locations, wherein each location extends downward from the nasal base and follows each of the relaxed skin tension lines (RSTLs) (location 5, identified as “marker 5 A” and “marker 5B” of marking system(s) herein). (ASPECT 156.)

[0221] In aspects, the disclosure provides the automated system of one or more of aspects 154-156, wherein the at least 7 specific locations further comprise (1) locations extending laterally on either side of the upper lip from the points on the upper vermillion border of locations 4A and 4B above on either side of the upper lip (for a total of two locations) to a point at or near the nasolabial fold line(s) of the relaxed skin tension line globe (locations H-A and H-B, identified as “marker H-A” and “marker H-B” herein); (2) locations extending laterally on either side of the upper lip from a point located between the nasal sill and the upper vermillion border along the locations identified as locations 4A and 4B above (for a total of two locations) (locations LE-A and LE-B (identified as “marker LE-A” and “marker LE-B” herein); or one, two, three or all four of locations H-A, H-B, LE-A, and LE-B. (ASPECT 157.)

[0222] In aspects, the disclosure provides the automated system of one or more of aspects 154-157, wherein the automated system generates and identifies specific points along each of at least locations 1, 2A, 2B, 3 A, 3B, 4A, and 4B, wherein each of the specific points divides the respective location into two segments, wherein one segment at each location represents a final lip height (“FH”, such as segment 2A-FH, 2B-FH, etc.) and the other segment at leach location represents an excision height at such location (“EX”, such as segment 2A-EX, 2B-EX, etc.), and wherein the automated system generates and identifies the specific points along each of the locations such that upon excision of the upper lip according to the excision height at each identified location in an upper lip lift aesthetic modification procedure, the final lip height of the upper lip at each identified location yields a slope of the upper vermillion border of between about 1 mm and about 3 mm, such as about 2 mm, between points 2A and 3 A; between points 3A and 4A; between points 2B and 3B; between points 3B and 4B; or between combinations of some or all of such pairs of points. (ASPECT 158.)

[0223] In aspects, the disclosure provides the automated system of one or more of aspects 154-158, wherein the automated system generates and identifies specific points along each of at least locations 1, 2A, 2B, 3 A, 3B, 4A, and 4B, wherein each of the specific points divides the respective location into two segments, wherein one segment at each location represents a final lip height (“FH”, such as segment 2A-FH, 2B-FH, etc.) and the other segment at leach location represents an excision height at such location (“EX”, such as segment 2A-EX, 2B-EX, etc.), and wherein the automated system generates and identifies the specific points along each of the locations such that upon excision of the upper lip according to the excision height at each identified location in an upper lip lift aesthetic modification procedure, the finallip height of the upper lip at each identified location yields an incisor display of between about 1 mm and about 4 mm, such as, e.g., about 2 mm to about 3 mm. (ASPECT 159.)

[0224] In aspects, the disclosure provides the automated system of any one or more of aspects 154-159, wherein the predicted aesthetic appearance yielded by defined characteristic(s) of location(s) generated or compiled by the automated system are used to morph the original image and to present to the system user the predicted aesthetic appearance if such characteristic(s) of such location(s) were applied in an aesthetic modification procedure.(ASPECT 160.)

[0225] In aspects, the disclosure provides the automated system of any one or more of aspects 154-160, wherein the characteristic(s) of location(s) generated or compiled by the automated system yielding the predicted aesthetic appearance can be saved or transmitted by the automated system. (ASPECT 161.)

[0226] In aspects, the disclosure provides the automated system of aspect 161, wherein the characteristic(s) of location(s) generated or compiled by the automated system yielding the predicted aesthetic appearance are saved as a feature set, the characteristic(s) of which used in an aesthetic modification procedure, such as an upper lip lift procedure, to achieve the predicted aesthetic appearance. (ASPECT 162.)

[0227] In aspects, the disclosure provides the automated system of any one or more of aspects 154-162, wherein the automated system makes one or more recommendation(s) for one or more intervention(s) to be applied as an ancillary procedure to the upper lip lift procedure. (ASPECT 163.)

[0228] In aspects, the disclosure provides the automated system of aspect 163, wherein the ancillary procedure is a corner lip lift procedure. (ASPECT 164.)

[0229] In aspects, the disclosure provides the automated system of any one or more of aspects 154-164, wherein the automated system is a mobile application. (ASPECT 165.)

[0230] In aspects, the disclosure provides the automated system of aspect 165, wherein the mobile application operates on a smartphone or tablet. (ASPECT 166.)

[0231] In aspects, the disclosure provides the automated system of any one or more of aspects 154-166, wherein the automated system functions on both Android and iOS platforms, or functions on platform(s) comprising one, some, most, generally all, substantially all, or all feature(s) and function(s) of Android and iOS platform(s); or functions on platform(s) developed from, derived from, or comprising, some, most, generally all, substantially all, or all feature(s)and function(s) of Android platform(s), iOS platform(s), or both, existing at the time of this disclosure. (ASPECT 167.)

[0232] In aspects, the disclosure provides the automated system of any one or more of aspects 154-167, wherein the automated system comprises use of one or more of mobile user interface framework(s) providing a single codebase enabling use across a plurality of platform(s); coding language(s) capable of supporting numerical and scientific computing; web server gateway interface(s) addressing HTTP request(s) and backend service(s) of the automated system(s); machine learning library(ies) to train an artificial intelligence model capable of detecting and modifying face landmark(s); and cloud-based web service(s). (ASPECT 168.)

[0233] In aspects, the disclosure provides the automated system of any one or more of aspects 154-168, wherein the automated system comprises use of one or more of Flutter, Python, Flask, PyTorch, and AWS; comprises use of one or more technology(ies) providing one, some, most, generally all, substantially all, essentially all, or all of the feature(s) and function(s) of one, some, most, generally all, substantially all, essentially all, or all of Flutter, Python, Flask, PyTorch, and AWS; or comprises use of one or mor technology(ies) built upon, developed from, derived from, or otherwise related to one, some, most, generally all, substantially all, essentially all, or all of Flutter, Python, Flask, PyTorch, and AWS. (ASPECT 169.)

[0234] In aspects, the disclosure provides the automated system of any one or more of aspects 167-169, wherein the automated system is provided by a mobile application provided on a smartphone or tablet. (ASPECT 170.)

[0235] In aspects, the disclosure provides the automated system of any one or more of aspects 154-170, wherein the predicted aesthetic appearance presented as the morphed image is generated by the automated system based upon a first set of user inputs and, after the automated system user reviews the presented morphed image representing the predicted target aesthetic appearance, one or more input parameter(s) of the system is / are adjusted and a new morphed image is generated by the system, representing an updated predicted result / outcome, wherein the process of iterating the morphed image representing the target appearance is iterated a plurality of times, e.g., 2 or more times, e.g., 5, 10, 15, or 20 or more times until parameters yielding target effect(s) are achieved. (ASPECT 171.)

[0236] In aspects, the disclosure provides the automated system of aspect 171, wherein the plurality of iterations are captured by machine-learning processes ) / programming / mechanism(s) present in the automated system and suitable targetaesthetic appearance(s), e.g., target aesthetic effect(s), are generated with detectably or significantly fewer iterations over time. (ASPECT 172.)

[0237] In aspects, the disclosure provides the automated system(s) of any one or more of aspect(s) 154-172, wherein the automated system(s) are used in any one or more of the procedure(s) and method(s) described in this exemplary aspects section of this disclosure.(ASPECT 173. )In aspects, the disclosure provides a method of using automated system(s) of any one or more of aspect(s) 154-172 in an aesthetic modification procedure such as an upper lip lift, e.g., a deep plane release upper lip lift procedure. (ASPECT 174.)

[0238] In aspects, the disclosure provides a method of generating marking system(s) according to any one or more of aspects 1-48, wherein the marking system(s) are generated virtually using any one or more of the automated system(s) described in aspects 154-172, and wherein the marker(s) as described in aspects 1-48 correspond to location(s) within such system(s), the corresponding location(s) having any one or more of the attribute(s) of their corresponding marker(s) described in aspect 1-48. (ASPECT 175.)Specific Exemplary EmbodimentsEmbodiment 1

[0239] According to certain aspects, the invention herein provides method(s) of generating predicted outcome imagery of a surgical aesthetic modification procedure. In aspects, such a method comprises providing a user with a computerized device. In aspects, such a computerized device can be, e.g., any automated system(s) described herein, such as, e.g., a laptop, smart device such as a smart phone or tablet, etc.

[0240] In aspects, such a computerized device comprises an interface that facilitates the collection of user input, such as, e.g., user input(s) described herein. In aspects, such an interface facilitates the transmission of the user input(s) to a computer component. In aspects, a computer component can be e.g., part of a cloud computing facility. In aspects, a computer component can be housed at a medical facility. In aspects, a computer component can be located in any location reachable by the computerized device interface.

[0241] In aspects, the computer component comprises a computer component processor component that performs one or more functions on the input(s). In aspects, the computer component returns output to the user through the interface. In aspects, a computer component processor component performs one or more processing function(s) alone or in cooperation with a computer component processor component.

[0242] In aspects, the computerized device comprises a user interface processing component. In aspects, a user interface processing component performs one or more functions locally on the computerized device, alone or in cooperation with a computer component processor component.

[0243] In aspects, a computerized device comprises a memory component. In aspects, a memory component can store data and one or more system instructions to be carried out by the user interface processing component, the computer component processor component, or both.

[0244] According to aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises prompting the computerized device user to provide user-identifying information through the interface of the computerized device. In aspects, via the user interface processing component, the computer component processor component, or both, user-identifying information is collected via the user interface processing component, the computer component processor component, or both. In aspects, such data is stored in the computerized device memory component.

[0245] According to aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises prompting the computerized device user to provide, via the computerized device interface, a computer component with one or more image data files. In aspects, an image data file corresponds to a photographic image of at least a portion of the computerized device user’s face, wherein such a user may be the subject of a potential surgical aesthetic modification procedure. In aspects, the method comprises prompting the user to provide one or more images for each of two or more distinct areas of the face through the interface and facilitating the association of the user image data file input with at least two different areas of the face.

[0246] In certain aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises subjecting one or more image data files provided by a computerized device user to analysis by a facial feature recognition artificial intelligence module (FFRAI), including, e.g., one or more landmark recognition technology (ies), to identify and locate a plurality of mapped facial features in the photographic image. In aspects such facial features are associated with the image data file. In certain aspects, the FFRAI comprises at least one facial feature recognition neural network (FFRNN) that is trained to recognize one or more facial feature(s), such as a plurality of facial features.

[0247] In aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises, e.g., through the operation of the user interfaceprocessing component, computer component processor component, or both, applying a face image morphing function. In aspects, a face image morphing function modifies one or more of the image data files according to one or more preprogrammed instructions. In aspects, a face image morphing function modifies one or more of the image data files according to one or more artificial intelligence models. In aspects, a face image morphing function modifies one or more of the image data files according to one or more preprogrammed instructions or one or more artificial intelligence models in a manner resulting in one or more initial morphed facial image files. In aspects, each morphed facial image file is expected to correspond with the outcome of performing the surgical aesthetic modification procedure according to the one or more preprogrammed instructions or the one or more artificial intelligence models resulting in the morphed image(s). According to aspects, the image morphing function is carried out in part by a face imaging morphing artificial intelligence model (FIMAIM) that is trained to generate morphed facial images based on the expected parameters of a surgical aesthetic modification procedure. According to aspects, the FIMAIM comprises at least one facial image morphing neural network (FIMNN), and the method comprises training the FIMNN based on user evaluation, medical expert evaluation, or a combination thereof.• In some aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises permitting the user of a computerized device to cause the user interface processing component of the device, the computer component processor component of the device, or both, to modulate one or more parameters associated with one or more selected facial feature elements from among the mapped facial features to generate one or more secondarily morphed facial image files. Such modulated elements can be, e.g., the adjustment of lengths associated with one or more marking(s) / location(s) described herein, such as one or more of marking 1, 2A, 2B, 3A, 3B, 4A, 4B, or others, or, e.g., segment(s) thereof. In certain aspects, at least one parameter of the one or more parameters associated with a plurality of facial feature elements is modulated to generate at least one secondarily morphed image file. In certain aspects, at least one user evaluation of at least one secondarily morphed image file is collected. In aspects, the method comprises evaluating the secondarily morphed image files by a morphing function evaluation artificial intelligence model (MFEAI), which optionally comprises one or more morphing function evaluation neural networks (MFENN(s)).

[0248] In some aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises permitting the user to evaluate each of the initialmorphed facial image files and each of the one or more of the secondarily morphed facial image files through the computerized device interface.

[0249] In some aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises storing information regarding the user’s evaluation in the memory component of the computerized device.

[0250] According to certain aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises performing a side-by-side comparison of at least two images selected from among an unmodified photographic image of the user’ s face provided by the user input, an initially morphed image file image, and one or more secondarily morphed image file images. In aspects, such a method comprises performing a side-by-side comparison of at least two images selected from among an unmodified photographic image of the user face provided by the user input, an initially morphed image file image, and one or more secondarily morphed image file images.

[0251] According to certain aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises providing the user with the option of selecting among a plurality of surgical aesthetic modification procedures or a combination of two or more plastic surgery procedures, wherein each surgical aesthetic modification procedure among the plurality of surgical aesthetic modification procedures corresponds to a surgical aesthetic modification procedure performed within a discrete portion of the face. In aspects, such a discrete portion of the upper face is characterizable as the upper lip, e.g., a region generally between the relaxed skin tension lines, and below the nasal base down to the upper vermillion border. In aspects, the method optionally comprises subjecting the image input provided by the user to a plurality of facial feature recognition artificial intelligence models, wherein each facial feature recognition artificial intelligence model of the plurality of facial feature recognition artificial intelligence models is trained to recognize one or more different facial features associated with a distinct part of the face (such as, e.g., the upper lip and regions of the face relatively near the upper lip).

[0252] According to certain aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises providing the computerized device user with the option of selecting among a plurality of surgical aesthetic modification procedures or, e.g., the option of selecting from a combination of two or more surgical aesthetic modification procedures, wherein each surgical aesthetic modification procedure among the plurality of surgical aesthetic modification procedures corresponds to a surgical aesthetic modificationprocedure performed within a discrete portion of the face such as, e.g., the upper lip. In aspects, such method(s) of generating predicted outcome imagery optionally comprises subjecting the image input provided by the user to a plurality of facial feature recognition artificial intelligence models. In aspects, each facial feature recognition artificial intelligence model of the plurality of facial feature recognition artificial intelligence models is trained to recognize one or more different facial features associated with a distinct part of the face.

[0253] According to certain aspects, a method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprises the user interface processing component, the computer component processor component, or both, carrying out one or more functions to evaluate whether the user’s image data file input is sufficient to perform an effective evaluation and prompting the user to provide additional or alternative image input if the one or more functions determine the image input is insufficient to provide an effective evaluation. In aspects, one or more such functions are performed at least in part by the operation of one or more artificial intelligence models that are trained in evaluating the sufficiency of user image input.Exemplary Embodiment 2

[0254] According to alternative embodiments provided herein are method(s) of directing a surgical aesthetic modification procedure, the method comprising any one or more of the step(s) of the method provided in exemplary embodiment 1 , and further wherein, through the operation of the computer component processor component, using user evaluation data to generate procedure-related output. In aspects, such output provides a medical practitioner with information that assists the medical practitioner in conducting related surgical aesthetic modification procedure(s).

[0255] In certain aspects, a method of directing a surgical aesthetic modification procedure wherein the surgical aesthetic modification procedure-related output comprises facial image data corresponding to the user’s face and providing one or more markings for guiding a plastic surgeon in applying the surgical aesthetic modification procedure. In certain aspects, the method comprises the computer component of computerized system(s) executing one or more functions that evaluate the user evaluation and providing a system-driven evaluation of the user evaluation to the medical practitioner. In aspects, the system-driven evaluation of the user evaluation comprises a proposed modification of the user evaluation. According to particular aspects, the operation of the computer component processor component facilitates a review of the user input, the system-driven evaluation, or both by the medical practitioner by relayingoutput and one or more prompts or one or more directions to a computer device used by the medical practitioner that is in communication with the computer component.

[0256] In certain aspects, a method of directing a surgical aesthetic modification procedure wherein the surgical aesthetic modification procedure-related output comprises augmented reality output, such as a display of one or more markings for guiding a plastic surgeon in applying the surgical aesthetic modification procedure in an augmented reality output.

[0257] According to some aspects, a method of directing a surgical aesthetic modification procedure further comprises the medical practitioner carrying out the surgical aesthetic modification procedure on the user based at least in part on the procedure-related output. In certain aspects, the method further comprises conducting a post-surgical aesthetic modification procedure evaluation and using the post-procedure evaluation to modify one or more Al models or other functions carried out by the processor component.Exemplary Embodiment 3

[0258] This disclosure provides new, inventive, and useful computer systems for, e.g., estimating the outcome of a plastic surgery method or facilitating aesthetic modification surgery patient and medical practitioner consultation comprising (1) a user interface device (UID) comprising a user interface processing component, a memory component, a data transmission component, and an interface component, wherein the UID interface component facilitates the collection of user input comprising user-identifying information and one or more image data files which are processed by the UID user interface processing component and stored in the UID memory component, and (2) a computer component (a primary computing component) that in operation is in communication with the UID and comprises a computer component processor component and a computer component memory component, wherein the computer component processor component comprises one or more artificial intelligence models (AIM(s)) that are specifically trained to recognize facial features, to modify facial images to reflect the likely outcome of a surgical aesthetic modification procedure, or both, and (3) a medical practitioner user interface device (MPID) that comprises a medical practitioner interface device processor component, a medical practitioner device memory component, a medical practitioner device data transmission component, and a medical practitioner interface device interface component, wherein the medical practitioner device interface facilitates the display of one or more image data files which are processed by the computer component processor component and which comprise procedure-related output comprising information that can direct the medical practitioner in performing one or more surgical aesthetic modification procedures.

[0259] Devices that can be used as UIDs or MPIDs are described herein and include smartphones, tablets, and laptops / personal computing devices. The “computer component” or primary computing component can be any suitable device or system that performs most of the processing steps, maintains most of the memory, or both, with respect to the overall capability of the system. In some aspects, the computer component comprises or is a cloud-based computing system, such as AWS, Azure, or a Google computing system. Although described separately here, in aspects, processing functionality is carried out in part on a local device level (an MP1D, UID, or both) and in part at a primary computing component level. For example, some parts of a function can be carried out by engine(s) / AIM(s) that operate at the local device level, the computing component level, or in part at both levels. In some aspects, some engines / AIMs are performed by a user / medical professional device, and other engines / AIMs are implemented at the computer component level.

[0260] The computer component processor component executes / operates one or more artificial intelligence models (AIM(s)) that are specifically trained to recognize a plurality of facial features, to modify facial images to reflect the likely outcome of a surgical aesthetic modification procedure, or to perform both types of functions. Typically, AlM(s) of a system include at least one facial feature image recognition AIM (in other parts of the disclosure referred to as landmark identification / marking systems). In aspects, systems include at least two different facial feature image recognition AIMs, wherein each can identify facial features in one or more parts of the face. In aspects, a computer component processor component is configured to operate a plurality of artificial intelligence models, wherein at least one of the plurality of artificial intelligence models is trained to recognize one or more facial features in user image data file input.

[0261] In an aspect, a system comprises at least two distinct facial feature recognition artificial intelligence models, wherein each of the at least two distinct facial feature recognition artificial intelligence models are trained to recognize one or more facial features in different portions of the face. For example, a system may be configured to allow a user to analyze the outcome of two or more different types of plastic surgery, which may be alternatively applied or concurrently performed (e.g., a subnasal lip lift and a corner lip lift). In such aspects, the system can include distinct AIMs that are configured to (e.g., trained to) recognize facial features / landmarks in two distinct parts of the face.

[0262] In aspects, a system comprises at least one artificial intelligence model that generates a morphed version of one or more of the image data files to establish one or moremorphed image data files in response to user input comprising one or more proposed changes in a parameter (characteristic or measurement) associated with a facial feature (e.g., the length of a line of the face). Such an AIM can take input data and, based on its training, prepare a morphed image based on the expected outcome of a modification. The modification can be a baseline modification or one or more further modifications that arise from user changes in one or more parameters of the method (e.g., changing the length of one or more facial lines).

[0263] In aspects, a system further comprises at least one artificial intelligence model that evaluates the sufficiency of user image data file input. Such an AIM can be trained to determine when a set of image data file input is effective for achieving a desirable level of performance in terms of, e.g., identifying, locating, or characterizing / measuring facial feature elements. Such systems can comprise instructions when such a level of sufficient data is not achieved, such as a looping function / prompting function that motivates or forces a user to add additional or alternative input data.

[0264] In aspects, systems can further comprise one or more artificial intelligence models that evaluate the efficacy of one or more system prompts, one or more system user instructions, one or more system outputs, or a combination thereof. These AIMs, which, like other AlMs described herein, can be NNs, can help facilitate and improve user interactions resulting in more effective collection and evaluation of data.DETAILED DESCRIPTION OF THE INVENTION

[0265] For convenience, both combinations of elements / steps and individual elements / steps may be described in this section of this disclosure. Despite the inclusion of passages focused on specific elements / steps, any aspect, facet, embodiment, or other description of particular step(s) or element(s) can be applied to any general description of the system(s) / method(s) of the disclosure, or any other recited element(s) / step(s) thereof, which are provided in any part of this disclosure.

[0266] As used herein, the word “exemplary” means “serving as an example, instance, or illustration.” The following detailed description is merely exemplary in nature and is not intended to limit application and uses. Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.

[0267] Throughout this disclosure, elements exemplified in figure(s) provided herewith may be indicated by their label reference identifier (label ID number). For example, reference to radial marker 1 may be followed by “(006)” herein, indicating that the element is labeled asnumber “6” in the provided Figures. Leading zeroes of label ID numbers provided in this disclosure are not provided in the labeling of figures. Accordingly, for example, “006” herein references label ID number “6” in the figures; “010A” references label ID number “10A” in the figures, and so on. Typically, 3-digit identifiers provided in this disclosure, e.g., “(640)” correspond directly to the same 3 -digit identifiers provided in the figures.

[0268] Provided herein are marking system(s) comprising a plurality of markers for use as a guide in the performance of one or more aesthetic modification procedures, such as, e.g., an upper lip lift procedure, e.g., a subnasal upper lip lift, e.g., a deep plane subnasal and comer lip lift procedure, e.g., such procedure(s) using a bull’s horn technique (bull’s horn subnasal incision technique). Herein, an “aesthetic modification procedure” is a surgical procedure performed with the intent of modifying the aesthetic appearance of the subject, such as the aesthetic appearance of, e.g., one or more feature(s) of, the subject’s face. Herein, use of the term “plastic surgery” or plastic surgery procedure,” and the like should be interpreted as an aesthetic modification procedure. Herein, “aesthetic modification procedure,” may also be interchanged with “surgical aesthetic modification procedure.” In aspects, a surgical aesthetic modification procedure is a modification technique performed within a discrete portion of the face, e.g., the upper lip. In aspects a discrete portion of the face is between and including the relaxed skin tension lines and between the nose and to and including the upper vermillion border. In aspects, the disclosure provides upper lip lift procedure(s), e.g., subnasal upper lip lift procedures, e.g., deep plan subnasal and comer lip lift procedure(s) with targeted design feature(s) / aesthetic effect(s) which provide at least generally standardized, at least substantially standardized, at least essentially standardized, predictable, consistent, or otherwise reliable outcome(s) by way of the incorporation of carefully designed / established marking system(s). In aspects, the disclosure provides aesthetic modification procedure(s) comprising use of, e.g., application of, such marking system(s). In aspects, the disclosure provides methods of using the marking system(s) in aesthetic modification procedure(s), such as, e.g., procedure(s) that aesthetically modify the upper lip. Further, in aspects, the disclosure provides method(s) of creating a visual guide for use in aesthetic modification procedure(s), e.g., method(s) of facial marking to establish a system of markers suitable for guiding aesthetic modification procedure(s) such as, e.g., an upper lip lift procedure, e.g., a subnasal upper lip lift procedure (e.g., with or without concomitant comer lip lift(s)) comprising application of a bull’s horn incision technique.

[0269] According to certain aspects, the disclosure provides marking system(s) and method(s) of their creation, application, and use(s), comprising the evaluation of facial feature(s)in order to establish one or more characteristic(s) of the marking system(s). Thus, in aspects, the disclosure provides method(s) of evaluation and characterization of a human subject (method(s) of assessment of human subject(s)) comprising the development of marking system(s) for use in achieving targeted aesthetic modification(s) resulting from procedure(s) incorporating use of the marking system(s).

[0270] According to certain aspects, the disclosure herein provides marking system(s) and related calculation(s) or other assessment(s) for use in upper lip lift procedure(s), such as a deep plane upper lip lift procedure. In aspects, such procedure(s) detectably or significantly improves lip shape, lip contour, lip volume, or both. In aspects, use of marking system(s) and related calculation(s) or other assessment(s) associated with the establishment of such marking system(s) avoid exaggerated, fake, or otherwise characterizable as negative appearance outcomes which can be associated with lip lift procedure(s) which lack use of such system(s), calculation(s), or assessment(s). In aspects, marking system(s) provided herein are characterizable as design marking(s). In aspects, such marking system(s) are established prior to the start of an aesthetic modification procedure. In aspects, such marking system(s) comprise a series of markers, e.g., radial marker(s) / marking(s) which enable a practitioner, patient, or both, to design what an upper lip will look like as a result of the performance of an upper lip lift procedure comprising use of the marking system(s). In aspects, marking system(s) disclosed herein allow for detectable or significant, e.g., improved, more refined, or combination(s) thereof, control of lip shape, lip slope, and lip display resulting from the performance of an upper lip lift procedure comprising use of the marking system(s). In aspects, marking system(s) comprise demarcation(s) indicating differentiation between the subfacial and subnasal lip. In aspects, marking system(s) aid in identifying whether the subject patient would benefit from the performance of a corner lip lift in addition to an upper lip lift (e.g., deep plane upper lip lift).

[0271] Further, regarding the differentiation between the subfacial and subnasal lip, in aspects, marking system(s) providing such differentiation between the subfacial and subnasal lip is used to guide decision(s) related to lip aging and the effect(s) thereof and the effect of surgery(ies), injectable(s), or both, on area(s) of the upper lip. In aspects, the differentiation between the subfacial and subnasal lip as indicated by marking system(s) provided herein differentiate two distinct areas: a first, more lateral area identified as the subfacial lip and lateral mouth, hanging from the anterior cheek and face, which will experience a greater degree of aging than a second, more medial area identified as the central subnasal lip, which is more densely attached to the pyriform and supported by the front teeth, and which will experience agreater sensitivity or effect of or to a lip lift procedure. In aspects, radial marker 4 (e.g., radial markers 4A (012A) and 4B (012B) described herein provide the differentiation between the subfacial and subnasal lip described here.

[0272] According to certain aspects, the disclosure provides marking system(s), described in detail herein, for use aesthetic modification procedures, such as upper lip lift procedures, e.g., subnasal upper lip lifts (e.g., with or without concomitant comer lip lift(s)) and, e.g., deep plane release upper lip lift modification procedures.

[0273] In certain specific aspects, the disclosure provides method(s) of aesthetically modifying the face of a human subject, the method(s) comprising performing one or more aesthetic modification procedure(s) on the face of the human subject wherein the aesthetic modification procedure(s) include(s), use(s), or otherwise incorporate(s) (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) - (3). Marking system(s) and such related method(s) are described herein.

[0274] In certain specific aspects, the disclosure provides method(s) of performing an upper lip lift procedure on a human subject, the method(s) comprising performing the upper lip lift procedure on the human subject wherein the procedure includes, uses, or otherwise incorporates (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) - (3). As stated above, marking system(s) and such related method(s) are described herein.

[0275] In certain specific aspects, the disclosure provides method(s) of performing an upper lip lift procedure, e.g., a subnasal upper lip lift procedure (e.g., with or without concomitant corner lip lift(s)) on a human subject, the method(s) comprising performing the upper lip lift procedure on the human subject wherein the procedure include(s), use(s), or otherwise incorporate(s) (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3)method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) -(3). As stated above, marking system(s) and such related method(s) are described herein.

[0276] In certain specific aspects, the disclosure provides method(s) of performing a deep plane release upper lip lift procedure on a human subject, the method(s) comprising performing the deep plane release upper lip lift procedure on the human subject wherein the procedure include(s), use(s), or otherwise incorporate(s) (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or(4) any combination of (1) - (3). As stated above, marking system(s) and such related method(s) are described herein.

[0277] In certain specific aspects, the disclosure provides method(s) of performing a comer lip lift procedure on a human subject, the method(s) comprising performing the corner lip lift procedure on the human subject wherein the procedure includes, uses, or otherwise incorporates (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) - (3). As stated above, marking system(s) and such related method(s) are described herein.

[0278] In certain specific aspects, the disclosure provides method(s) of performing a nasal base suspension procedure on a human subject, the method(s) comprising performing the nasal base suspension procedure on the human subject wherein the procedure includes, uses or otherwise incorporates (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) - (3). As stated above, marking system(s) and such related method(s) are described herein.

[0279] In certain specific aspects, the disclosure provides method(s) of performing a muscle suspension procedure on a human subject, the method(s) comprising performing themuscle suspension procedure on the human subject wherein the procedure include(s), use(s), or otherwise incorporate(s) (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) - (3). As stated above, marking system(s) and such related method(s) are described herein.

[0280] In certain specific aspects, the disclosure provides method(s) of performing an upper lip lift procedure, a subnasal upper lip lift procedure, a deep plane release upper lip lift procedure, a corner lip lift procedure, a nasal base suspension procedure, a muscle suspension procedure, or a combination of any or all thereof on a human subject, the method(s) comprising performing the procedure(s) on the human subject wherein the procedure(s) include(s), use(s), or otherwise incorporate(s) (1) marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (2) method(s) of incorporating marking system(s) comprising one or more of the characteristic(s) of marking system(s) provided herein; (3) method(s) comprising the development / establishment of marking system(s) comprising one or more characteristics of the marking system(s) described herein; or (4) any combination of (1) - (3). As stated above, marking system(s) and such related method(s) are described herein.

[0281] In aspects, the disclosure herein provides method(s) of achieving target aesthetic design feature(s) of the upper lip of a human subject, such as, e.g., a target vermillion slope or other design feature(s) (e.g., target aesthetic effect(s)) described herein, wherein the method(s) comprise use of, application of, or incorporation of any of the method(s) described above.

[0282] In aspects, the disclosure herein provides method(s) of addressing age-related changes in the upper lip of a human subject, such age-related changes in the upper lip being described elsewhere herein, wherein the method(s) comprise use of, application of, or incorporation of any of the method(s) described above.

[0283] In aspects, the disclosure herein provides method(s) of achieving target aesthetic design feature(s) of the upper lip, e.g., a target vermillion slope or other design feature(s) (e.g., target aesthetic effect(s)) described herein; addressing specific age-related changes in the upper lip in a human subject; or both, wherein the method(s) comprise use of, application of, or incorporation of any of the method(s) described above.

[0284] In aspects, the disclosure provides method(s) for addressing (e.g., detectably or significantly reducing or eliminating) difference(s), e.g., asymmetry(ies), in one or morefeature(s) of the upper lip such as asymmetry(ies) associated with the nasal base, upper lip height, vermillion slope, philtrum, etc. In aspects, such asymmetry(ies) can be naturally occurring or as a result of one or more prior aesthetic intervention(s) e.g., application of lip fillers, surgical procedure(s), or both. In aspects, such method(s) comprise use of, application of, or incorporation of any of the method(s) described above.

[0285] In aspects, the disclosure provides method(s) of achieving target aesthetic design feature(s) such as a target vermillion slope, addressing age-related change(s) in the upper lip, or both, in a human subject wherein the method(s) further allow for addressing (e.g., delectably or significantly reducing or eliminating) difference(s), e.g., asymmetry(ies) across the upper lip, wherein the method(s) comprise use of, application of, or incorporation of any of the method(s) described above.

[0286] In aspects, method(s) provided by the disclosure comprise use of, application of, or otherwise incorporating marking system(s) described herein. In aspects, method(s) provided by the disclosure comprise use of, application of, or otherwise incorporating marking system(s) described herein, wherein the marking system(s) comprise any one or more features of marking system(s) provided herein.Evaluation & Characterization - Pre-Procedure: Establishing Marking System(s)

[0287] According to certain aspects, the disclosure provides marking system(s), e.g., facial marking system(s), method(s) of their establishment, and method(s) of their use in and application to aesthetic modification procedure(s), wherein one or more characteristic(s) of marking system(s) are established based upon an evaluation and characterization of one or more facial features or characteristics of a human subject undergoing an aesthetic modification procedure.

[0288] As is described in more detail elsewhere herein, establishment of marking system(s) of this disclosure can be partially or completely automated. In aspects, pre-procedure evaluation is conducted only by human(s). In alternative aspects, pre-procedure evaluation is conducted by a combination of human(s) and technology, such as technology comprising artificial intelligence function(s). In still further aspects, pre-procedure evaluation is conducted only by technology (technology alone), such as by technology comprising artificial intelligence function(s).

[0289] In aspects, the evaluation and characterization of facial feature(s) or characteristic(s) identifies specific feature(s) / characteristic(s) of the face (e.g., of the upper lip) which require(s) modification in order to attain one or more design feature(s), such designfeature(s) being identified as element(s) of a target design or target aesthetic appearance as described elsewhere herein. In aspects, an exemplary element of a target design can be, e.g., a preferred upper vermillion slope. In aspects, the evaluation and characterization of facial feature(s) or characteristic(s) identifies genetically pre-determined or, e.g., age-related change(s), e.g., age-related change(s) of the upper lip and difference(s) in the same across the span of the upper lip.

[0290] In certain aspects, the evaluation and characterization of facial feature(s) is performed in advance of, in conjunction with, or at least in part in advance of, and in conjunction with, the establishment of marking system(s) described herein. In aspects, the evaluation and characterization of facial feature(s) is performed in preparation for an upper lip aesthetic modification procedure, such as, e.g., an upper lip lift, e.g., a subnasal upper lip lift, e.g., a subnasal upper lip lift comprising use of a bull’s horn incision technique, such as a deep plane release upper lip aesthetic modification procedure comprising use of a bull’s horn incision technique. In aspects, the evaluation and characterization of facial feature(s) further comprises evaluating whether the subject may benefit from a procedure distinct from a subnasal upper lip lift. In aspects, the evaluation and characterization of facial feature(s) further comprises evaluating the subject for their ability to benefit from an ancillary procedure such as, e.g., a concomitant corner lip lift, nasal base suspension, muscle suspension, neurotoxin injection(s) into depressor(s), volumization of a triangle inferior to the commissure, facelift, or a combination of any or all thereof, in order to attain a target aesthetic appearance.

[0291] According to certain aspects, the evaluation and characterization of facial feature(s) or characteristic(s) informs parameter(s) or design of marking system(s). In aspects, the evaluation and characterization of facial feature(s) or characteristic(s) establishes one or more parameters related to an upper lip lift procedure and, optionally, a concomitant comer lip lift, nasal base suspension, muscle suspension, neurotoxin injection(s) into depressor(s), volumization of a triangle inferior to the commissure, facelift, or a combination of any or all thereof.

[0292] In aspects, one or more step(s) of evaluation and characterization of facial feature(s) or characteristic(s) provided herein can be performed by a human. In aspects, evaluation and characterization step(s) described herein can be performed by a human aided by one or more other tool(s) or system(s) such as one or more computer- or software-related tool(s) or system(s). In aspects, one or more step(s) of evaluation and characterization of facial feature(s) or characteristic(s) provided herein can be performed by a human aided by one ormore robotic tool(s) or system(s). In aspects, one or more step(s) of evaluation and characterization of facial feature(s) or characteristic(s) provided herein can be performed by a tool(s) or system(s) incorporating use of artificial intelligence. In aspects, one or more step(s) of evaluation and characterization of facial feature(s) or characteristic(s) provided herein can be performed at least mostly without, at least generally without, at least substantially without, at least essentially without, essentially without, or without human involvement. In aspects, evaluation and characterization of facial feature(s) or characteristic(s) provided herein comprise(s) use of preoperative photography. In aspects, preoperative photography detectably or significantly improves upon the assessment of (detectably or significantly increases the sensitivity in identifying) a requirement for asymmetric excision to be utilized in the upper lip lift procedure, one or more ancillary procedure(s) performed in association with the upper lip lift procedure, or both. In aspects, the disclosure provides method(s) of facial assessment in preparation for one or more aesthetic modification procedure(s), such as, e.g., upper lip lift procedure(s), e.g., subnasal upper lip lift procedures or, e.g., deep plane release upper lip modification procedure(s) (e.g., with or without concomitant corner lip lift(s)), wherein the method(s) comprise(s) the application of one or more automated, non-human, or computer-based system(s) comprising software-driven analysis to, e.g., application of artificial intelligence of, a scan of, an image of, a live presentation of, or any combination thereof, the subject’s face to establish one or more feature(s) of one or more marking(s) of the guide / marking system used in the method(s).

[0293] According to aspects, one or more step(s) of evaluation and characterization of one or more facial feature(s) or characteristic(s) provided herein comprise viewing the profile view of the subject. In aspects, considering the profile view of the subject allows for consideration of slope and projection as step(s) used in establishing target aesthetic effect(s), e.g., a target aesthetic appearance and to identify one or more surgical requirement(s) required to attain the target aesthetic effect(s) / target aesthetic appearance.Target Design

[0294] In aspects, the disclosure provides marking system(s) which serve(s) as a guide in the performance of aesthetic modification procedure(s), wherein one or more element(s) of the marking system(s) (e.g., one or more marker(s) / indicator(s) of the marking system(s)) are designed according to a targeted aesthetic outcome or effect(s), e.g., to achieve a target aesthetic appearance resulting from the procedure(s) incorporating application or use of the markingsystem(s). According to particular aspects, a target design can be, e.g., presented as a morphed image within automated system(s) described elsewhere herein.

[0295] In aspects, a target aesthetic appearance can be any target aesthetic appearance deemed desirable, such as identified by subject(s) or practitioner(s) as desired outcome(s) of aesthetic modification procedure(s). In certain aspects, a target aesthetic appearance can comprise, e.g., one or more targeted aesthetic feature(s) or characteristic(s) of feature(s) such as vermillion slope, tooth show, and facial balance / symmetry. In certain specific aspects, a target aesthetic appearance can comprise, e.g., one or more targeted aesthetic feature(s) or characteristic(s) of feature(s) such as, e.g., natural facial balance or more specifically natural balance of the upper lip; optimized muscle function; a proportionate lip height-to-lip width; lip proportion to one or more surrounding structures, e.g., the nose, chin, etc.; lip proportion to the remainder of the entirety of the face; amount of tooth (incisor) display; easy or appropriate mouth closure; slope of the upper vermillion border (020) from medial (center) to lateral (side); amount of (level or degree of) exposure of the red vermillion along the length of the upper lip; volume of the red vermillion along the length of the lip; alleviated angular depression or buried vermillion at comer(s) of the mouth; continuity of the internal arc of the upper lip along the wetdry border; symmetry at the bow peaks of Cupid’s bow; amount of anterior (forward) projection on lateral (side / profile) view; vertical slope on lateral (side / profile) view; or other such feature(s) or characteristic(s) identified in the art.Procedure Candidates

[0296] In aspects, the marking system(s) and method(s) / application(s) of their use, e.g., marking system(s) herein for use in upper lip lift procedure(s), e.g., deep plane upper lip lift procedures (e.g., using the bull’s hom incision technique) are suitable for use in aesthetic modification procedure(s) for a wide variety of candidate subjects, including subject(s) for whom one or more procedure(s) (such as an upper lip lift, deep plane upper lip lift, or, e.g., such lifts without the marking system(s) herein) would not otherwise be appropriate. In aspects, suitable candidate(s) on or with which marking system(s) and method(s) / application(s) of their use provided by the disclosure are suitable include, e.g., subjects at or under the age of 50 years; subjects older than 50 years; subjects from any number of ethnicities; subjects having typical skin thickness; subjects having skin which is detectably or significantly thinner than the average population of people of the same age and ethnicity; subjects having skin which is detectable or significantly thicker than the average population of people of the same age and ethnicity; subjects having smooth, youthful skin; subjects having wrinkled skin; subjects with distinctfacial features such as particularly shaped noses, e.g., upturned noses; and in aspects other characteristic(s) known in the art which would otherwise exclude patients from being candidates for particular procedure(s). In aspects, marking system(s) and method(s) / application(s) of their use, or, e.g., procedure(s) incorporating marking system(s) provided herein provide detectably or significantly more predictable outcomes than comparable technique(s) practiced in the art, e.g., upper lip lift procedure(s) or comer lift procedure(s) lacking system(s) and method(s) herein, provide detectably or significantly reduced scarring compared to comparable technique(s) practiced in the art, e.g., upper lip lift procedure(s) or comer lift procedures lacking system(s) and method(s) herein, or both. Thus, in providing detectably or significantly more control over, e.g., tooth show / incisor display, scarring, nasal base position, nasal base widening, lip shape, etc. system(s) and method(s) provided herein are applicable to a broad range of candidate(s). In aspects, system(s) and method(s) described herein are applicable to subject(s) characterized as having a “mean” or “snarling” appearance, as incorporating within system(s) and method(s) described herein are mechanisms (e.g., calculations, considerations, or algorithms) which can detectably or significantly change the character of one’s appearance (e.g., upper lip) such that a “nicer” or more “friendly” appearance is provided.

[0297] According to aspects, a candidate is a user of automated system(s) described herein. In aspects, user(s) of automated system(s) described herein can be candidate(s) for one or more procedure(s) described herein, such as, e.g., upper lip lift procedure(s), corner lift procedure(s), or both.Upper Lip Lift Procedure

[0298] In aspects, the disclosure herein provides marking system(s) suitable for use in an aesthetic modification procedure, e.g., an upper lip lift surgical procedure. In aspects, marking system(s) herein are suitable for use in any upper lip lift procedure. In aspects, marking system(s) provided herein are suitable for use in an upper lip lift procedure utilizing a bull’s horn surgical incision technique. In aspects, marking system(s) provided herein are suitable for use in an upper lip lift procedure utilizing a bull’s horn surgical technique, such a technique recognized by those skilled in the art, including one or more variations of such a technique comprising maintenance / use of the bull’s horn-shaped incision / excision characteristic of the technique.Deep Plane Release Upper Lip Lift

[0299] In certain specific aspects, the disclosure herein provides marking system(s) suitable for use in an aesthetic modification procedure, e.g., an upper lip lift surgical procedure, wherein the upper lip lift procedure is a subnasal upper lip lift procedure, e.g., a deep planerelease upper lip aesthetic modification procedure (e.g., with or without concomitant corner lip lift(s)). In aspects, the disclosure herein provides a subnasal and comer lip lift procedure, e.g., a deep plane release subnasal and corner lip lift procedure comprising specific design element(s) provided by marking system(s) described herein. In aspects, a deep plane release upper lip aesthetic modification procedure is similar to a centrally vectored advancement flap, wherein lateral portions are pulled superior-medially rather than purely in a vertical vector. This technique is described in detail by the present inventor, Dr. Benjamin Talei, in Facial Plast Surg Clin N Am 27 (2019) 385-398 supra). In aspects, however, such deep plane release upper lip lift aesthetic modification procedure(s) described herein comprise, in aspects, incorporation of concomitant corner lip lift(s). Further, in aspects, such deep plane release upper lip lift aesthetic modification procedure(s) described herein comprise use of specific design system(s), e.g., marking system(s), e.g., marking systems established using specific design principle(s) (as described herein), to provide detectably or significantly increased predictability of results(s) compared to prior procedures or comparable procedure(s) known in the art, and at least generally, at least substantially, or at least essentially standardized outcomes.

[0300] According to certain aspects, upper lip lift procedure(s) referenced herein are characterizable as deep plane lip lift(s), and the marking system(s) herein yield a deep plane lip lift design. In aspects, such a deep plane lip lift design uses a rotational advancement of lip skin toward the nose. In aspects, a rotational advancement of lip skin toward the nose is hinged around the apex of the incision at the lateral ala. In aspects, radial marking(s) of marking system(s) disclosed herein indicate certain location(s) where excision will result in a more effective vertical lift than other location(s). E.g., in aspects, marking system(s) provided herein can comprise one or more medial marking(s) and one or more lateral marking(s), wherein medial marking(s) will experience a detectably or significantly more effective vertical lift than lateral radial marking(s), which have a more diagonal vector. In aspects, such marking(s) aid in the rotational advancement described here.Marking System(s)

[0301] Described in detail herein are marking system(s) which, when the feature(s) and characteristic(s) of which are applied in aesthetic modification procedure(s), result in a predicted aesthetic appearance. As provided by this disclosure, marker(s) of marking system(s) herein are associated with specific location(s) of a human face, e.g., specific location(s) of the upper lip. In certain aspects, marker(s) described herein can be literal, physical mark(s) on the skin. In other aspects, marker(s) can represent location(s) on or of the human face, e.g., the location(s)described herein associated with each of the marker(s) of marking system(s) described herein. As such, in aspects, this disclosure identifies specific location(s), and specific characteristic(s) at and of such specific location(s), wherein modification(s) made at such specific location(s) (as described herein related to the use of marking system(s) disclosed herein) result in the modification of the aesthetic appearance of the human face.

[0302] That is, marking system(s) provided herein may not necessarily be physical marking(s) made on human skin; rather, in aspects, such marking(s) can be virtual, as generated by automated system(s). In aspects, such marking(s) exist only as data. In aspects, one, some most, generally all, substantially all, essentially all, or all characteristic(s) of such marking(s), e.g., their location(s), total length(s), segment length(s), and the like as described herein exist only as data, wherein such data can be applied to an original image of, e.g., a human face, wherein the application of such data to the original image can result in the generation of a new, morphed image, reflecting the results of such application to the human face wherein feature(s) / landmark(s) of the morphed image reflect that of the marking data.

[0303] Accordingly, disclosure related to a length and positioning of marker(s), including segment(s) thereof, should be interpreted as also or alternatively disclosing the length of the path associated with such a location identifiable by such a marker in virtual form (e.g., a virtual marker identifies a location, and the location can be identified by the language used to describe associated marking(s) of marking system(s) herein.)

[0304] According to aspects, one, some, most, generally all, substantially all, essentially all, or all marking(s) of marking system(s) provided herein are generated by computer or are generated in a computer-aided manner, e.g., with the use of computer-aided technology.

[0305] In aspects, the disclosure provides marking system(s), procedure(s), and method(s) wherein the marking system(s) results in target aesthetic effect(s) when applied in procedure(s) and method(s) described herein; the procedure(s) and method(s) performed to achieve target aesthetic effect(s) described herein; or both are established, performed, or both established and performed utilizing artificial intelligence technology. According to certain aspects, the use of landmark recognition technology, morphing technology, or both delectably or significantly improve(s) the predictability of result(s) / outcome(s) of aesthetic modification procedures comprising their incorporation compared to the predictability of result(s) / outcome(s) of the same aesthetic modification procedure(s) lacking their use. In aspects, this is because use of such automated system(s) and method(s) comprise presenting or the ability to present an image representing the predicted outcome(s) of such procedure(s).

[0306] In aspects, the disclosure described herein provides marking system(s) for use on a human subject in the preparation for, execution of, or both, an aesthetic modification procedure. In aspects, marking system(s) provided herein are made on the face of a subject, e.g., human subject, in preparation for one or more aesthetic modification procedure(s). In aspects, marking system(s) are made virtually, e.g., are applied to digital image(s) of, e.g., the face of a subject within automated system(s) described herein. In aspects, marking(s) of virtual marking system(s) of automated system(s) disclosed herein are visible indicator(s) placed upon an image and which a viewer of the image can see / visually identify. In aspects, marking(s) of virtual marking system(s) of automated system(s) described herein are not visible indicators, yet are digitally present as data which can be applied to image(s) according to automated system use. In certain aspects, the digital presence of data representing marking(s) of virtual marking system(s) is visible as recognizable morphing of an original image according to characteristic(s) / attribute(s) of the marker(s). In aspects, marking system(s) are used on the face or image of a face of a human subject in the preparation for, execution of, or both, such aesthetic modification procedure(s). In aspects, the marking system(s) are used in an upper lip lift procedure, e.g., a subnasal upper lip lift procedure, e.g., a deep plane release upper lip lift procedure (e.g., with or without concomitant corner lip lift(s)). In aspects, the upper lip lift procedure comprises use of a bull’s horn surgical technique. In aspects, marking system(s) comprise one or more components (e.g., marking(s)) suitable for use in one or more procedures performed concomitant to an upper lip lift procedure, such as, e.g., a comer lip lift, nasal base suspension, muscle suspension, or combination of any or all thereof.

[0307] In the context of disclosure regarding “use” of marking system(s) described herein, phrases such as (but not necessarily limited to) “incorporation,” “application,” or “use” (and the like) mean the marking system(s) being a functional component of procedure(s) and method(s).

[0308] In aspects, marking system(s) provided herein provide mathematical guidance for attaining a target aesthetic design result. In aspects, the mathematical guidance of the marking system further indicates when or if an ancillary procedure, such as, e.g., a corner lip lift procedure, should be added / included to a first or primary procedure, sch as an upper lip lift, in order to achieve a target aesthetic effect such as a target slope of the upper vermillion border (020) (the upper vermillion border being identified in the figure(s) provided herewith; see, e.g., Figure 2A.)

[0309] In aspects, marking system(s) provided herein provide mathematical relationship(s) between two or more marker(s) of the marking system(s) which, when marking system(s) are used / incorporated in method(s) such as method(s) comprising performance of aesthetic modification procedure(s), the marking system(s) yield target effective effect(s) with significant predictability and consistency, e.g., predictability, consistency, or both, compared to at least generally the same or similar, at least substantially the same or similar, at least essentially the same or similar, essentially the same or similar, or the same procedure! s) / method(s) performed on subject(s) or populations of subject(s) which present with at least generally similar, at least substantially similar, at least essentially similar, essentially the same, or the same targeted aesthetic effect performed without such system(s).

[0310] In aspects, these mathematical relationships can be programmed and used in automated methods, such as, e.g., automated methods described herein. In aspects, these mathematical relationships can be programmed and used in automated methods, such as, e.g., morphing software, wherein such software is provided an image of a subject and software program(s) utilize the provided mathematical relationships, without user input or in conjunction with one or more user-provided parameters, to provide images to the subject or practitioner exemplifying a predicted aesthetic result if such relationship(s) and parameter(s) are applied to guide aesthetic modification procedure(s). In aspects, results from such program(s) can be modified or edited by a system user to adjust results, e.g., adjust the calculations, to achieve desired aesthetic effect(s).

[0311] In certain aspects, marking system(s) comprise a single marking described herein. In certain aspects, marking system(s) comprise at least 2, such as for example, >~3, >~4, >~5, >~6, >~7, >~8, >~9, >~10, >~11, >~12, >~13, >~14, or >~15 markings. In aspects, marking(s) are only suitable for use in / applicable to upper lip lift, e.g., subnasal upper lip lift, procedure(s). In aspects, marking(s) are used in / applicable to / suitable for use in comer lip lift procedure(s), nasal base suspension procedure(s), or muscle suspension procedure(s). In aspects, marking(s) are suitable for use in both an upper lip lift procedure and one or more ancillary / concomitantly performed procedure(s), e.g., a comer lip lift procedure, a nasal base suspension procedure, a muscle suspension procedure, or combination of any or all thereof. In aspects, one or more marking(s) of a marking system are applicable to (suitable for use in or beneficially used in) a first procedure but not applicable to (suitable for use in or beneficially used in) at least a second concomitantly performed procedure(s) wherein the marking(s) are present for the conduct of the at least second concomitantly performed procedure(s). In aspects, marker(s) or at a minimum oneor more element(s) of marker(s), e.g., point(s) along marker(s), position(s) of marker(s), length(s) of marker(s), etc. are applicable to (suitable for use in or beneficially used in) both a first procedure and an at least second procedure. For the purposes of exemplification, in aspects, a first procedure in this paragraph can be, e.g., an upper lip lift procedure, e.g., a subnasal upper lip lift procedure, e.g., a deep plane release upper lip lift procedure or a corner lip lift procedure, and an at least second procedure in this paragraph can be, e.g., a corner lip lift procedure, nasal base suspension procedure, muscle suspension procedure, or a combination of any or all thereof.

[0312] In aspects, marking system(s) provided herein are guide(s), e.g., comprise one or more marking(s) serving as guide(s) for use before, during, or both before and during an aesthetic modification procedure, e.g., an upper lip lift procedure, e.g., a subnasal upper lip lift procedure (e.g., (e.g., with or without concomitant comer lip lift(s)) and provide a “map” for guiding a practitioner during the procedure toward a pre-determined, target aesthetic effect / result. In aspects, the marking system(s) establish a target aesthetic result, e.g., lip shape, resulting from the aesthetic modification procedure (e.g., subnasal upper lip lift procedure performed concomitantly with a corner lip lift procedure).

[0313] In aspects, marking system(s) provided herein establish a natural balance of the upper lip when incorporated into an upper lip aesthetic modification procedure. In aspects, marking system(s) provided herein, when incorporated into / used in / applied to aesthetic modification procedure(s) yield an optimized muscle function resulting from the procedure(s). In aspects, marking system(s) provided herein indicate when an ancillary procedure, such as, e.g., a corner lip lift procedure, should be added / included to a first or primary procedure, such as an upper lip lift. In aspects, the mathematical guidance of the marking system indicates when an ancillary procedure, such as, e.g., a corner lip lift procedure, should be added / included to a first or primary procedure, sch as an upper lip lift, in order to achieve a target aesthetic effect such as a target slope of the upper vermillion border (020).

[0314] According to aspects, the disclosure herein provides marking system(s) and analysis(es) leading to the development thereof, wherein the complexity of upper lip lift design is delectably or significantly reduced by the application of predetermined standard(s) directed to specific characteristic(s) of upper lip, nasal, or upper lip and nasal feature(s) known to yield aesthetically pleasing result(s), e.g., consistent upper vermillion border (020) slope. In aspects, such predetermined standard(s) are provided as characteristic(s) of marker(s) of marking system(s) herein, such as length(s) of marker(s), positioning of marker(s), differences in length(s) or positioning of marker(s), differences in portions of marker(s), relationship(s)between marker(s) or portion(s) thereof (e.g., ratios of length(s) of marker(s) or ratio(s) of certain portion(s) / segment(s) of marker(s), etc. as described herein. Upper lip lift design requires balancing many consideration to yield a target outcome. In aspects, marking system(s) and method(s) of their use / application provided herein, and, e.g., procedure(s) comprising the system(s) and method(s) provided herein detectably or significantly simplify such considerations by providing a mechanism for guiding practitioner(s) to establish condition(s), e.g., parameter(s) according to which significantly more predictable outcome(s) are achieved.

[0315] According to certain aspects, marking(s) and marking system(s) described here can comprise any one or more of the feature(s) or characteristic(s) described by any one or more of Figures 2A - 20, Figures 3A and 3B, Figures 4 - 7, or any combination(s) of any or all thereof.Group A (e.g., “Left”) Marking(s) & Group B (e.g., “Right”) Marking(s)

[0316] In aspects, marking system(s) provided herein comprise marker(s) which individually may be located on a single side of the midline (e.g., on a single lateral side of radial marker 1 (006). In aspects, such marker(s) can be present in pairs, wherein the first marker of a pair is positioned on a first lateral side of the midline (e.g., put simply, on one side of the subject’s upper lip, e.g., left or right side of the midline of the subject’s upper lip) which the second marker of a pair is positioned on the opposing lateral side of the midline (e.g., on the opposite side of the subject’s upper lip, e.g., the left or right side of the midline of the subject’s upper lip opposite its pair.) In certain aspects, marking system(s) provided by the disclosure comprise one or more markers, e.g., 2 or more, 3 or more, or 4 or more markers positioned on a single side of a centrally positioned first marker (e.g., radial marking 1 (006)). In aspects, marker(s) positioned on a single side of the midline of the upper lip of a subject, e.g., on a first side of radial marking 1 (006) (lateral to radial marking 1 (006) in a single direction), are referred to herein for ease of reference as “Group A” markings.

[0317] For example, Group A marking(s) may be markings positioned on the left side of a subject’s upper lip. In certain aspects, a Group A marking(s) may each have a corresponding Group B marking on the opposing side of the subject’s upper lip, such as, e.g., a corresponding marking positioned on the right side of a subject’s lip.

[0318] In aspects, marker(s) positioned on a single side of the midline of the upper lip of a subject, e.g., on a second side of radial marking 1 (006) (lateral to radial marking 1 (006) in a single direction), and opposite that of a first group of markings (Group A markings), areidentifiable as a second group of markings, referred to herein for ease of reference as “Group B” markings.

[0319] For example, Group B marking(s) may be markings positioned on the right side of a subject’s upper lip. In certain aspects, a Group B marking(s) may each have a corresponding Group A marking on the opposing side of the subject’s upper lip, such as, e.g., a corresponding marking positioned on the right side of a subject’s lip.

[0320] In aspects, a Group A-Group B marking pair (“A-B pair”) are at least generally, at least substantially, at least essentially, essentially, or are mirror images of one another in terms of position / positioning on the upper lip, e.g., in their identification of facial feature(s) on opposite sides of a midline. However, one member of such an A-B marking pair may have one or more characteristic(s) which is different from its counterpart in order to address an asymmetry, such as, e.g., it may comprise an excision height segment length, a final lip height segment length, etc. which is detectably or significantly different from its counterpart.Upper Excision Boundary Marker(s)

[0321] In aspects, marking system(s) provided herein comprise a marking along the nasal base. In aspects, the marking along the nasal base indicates an upper excision boundary (002), e.g., the uppermost boundary of a surgical excision performed as at least a part of a procedure incorporating the marking system(s). In aspects, the upper excision boundary (002) is the upper excision boundary of a bull’s horn-shaped excision made as part of an upper lip lift procedure, e.g., subnasal upper lip lift procedure, e.g., deep plane release upper lip lift modification procedure (e.g., with or without concomitant corner lip lift(s)). Figures, e.g., 2A, 2N and 3A and 3B illustrating exemplary positions of an upper excision boundary marker / marking, indicated as element (002) of the figures. As with any one or more other marker(s) described herein, such a marker can be, e.g., a virtual marker, e.g., identified by landmark detection technology of automated system(s) provided herein.

[0322] In aspects, an upper excision boundary marking (002) comprises the uppermost point (e.g., incision point of each of at least one, typically a plurality of, radial marking(s) of the marking system(s) (described elsewhere herein.)

[0323] In aspects, the upper excision boundary marking (002) is an at least substantially horizontal marking. In aspects, the upper excision boundary marking (002) follows horizontally along the subnasal, perialar crease. According to certain aspects, the upper excision boundary marking (002) identifies the uppermost portion of the upper lip to be excised in an upper lip lift procedure comprising use of the marking system(s). In aspects, the upper excision boundarymarking (002) does not extend beyond the natural ending of the subnasal, perialar crease of the subject.

[0324] In aspects, an upper excision boundary marking (002)comprises two peaks. In aspects, the two peaks are positioned on either side of the midline at the divergence of the medial crural footplate and the nasal sill.

[0325] In aspects, an upper excision boundary / boundary marking (002), in conjunction with a lower excision boundary / boundary marking (004), define a portion of the upper lip to be excised in an upper lip lift procedure comprising use of the marking system(s).Lower Excision Boundary Marker(s)

[0326] In aspects, marking system(s) comprise a lower excision boundary marker (004). In aspects, the lower excision boundary marker (004) is highly adjustable from patient-to-patient and is made according to specific requirements of the procedure needed to attain a target aesthetic effect. In aspects, the lower excision boundary marker (004) comprises a collection of second, lower incision point markers (with the first, upper incision point markers being encompassed by the upper excision boundary marker (002)) and is a mid-line marking between the nasal sill and the upper vermillion border (020). As is described here, in aspects the lower excision boundary marker (004) indicates the lower incision point of each radial marking(s). A lower excision boundary marker (004), in aspects, is established by connecting two or more lower incision point markers, each such lower incision point marker established base upon target aesthetic effect(s). In aspects, a lower excision boundary marker (004) is not completely established until at least some, most, generally all, or all lower incision point markers are established, until some, most, generally all, or all upper vermillion border (020) points are established, or some, most, generally all, or all of both lower incision point markers and upper vermillion border (020) points are established. Figures, e.g., 2N and 3 illustrates an exemplary position of a lower excision boundary marker (004), illustrated as element (004) of the figures.

[0327] In aspects, a lower excision boundary marker (004) is substantially horizontal. In aspects, a lower excision boundary marker (004) is positioned below the upper excision boundary marker (002) with the distance between the upper excision boundary marker (002) and the lower excision boundary marker (004) defining a portion of the upper lip to be excised in an upper lip lift procedure incorporating the marking system(s). In aspects, the distance between any point along the lower excision boundary marker (004) and the upper excision boundary marker (002) defines (represents) the excision height at such location.

[0328] In aspects, a lower excision boundary marker (004) is positioned above the upper vermillion border (020) with the distance between the upper excision boundary marker (002) and the upper vermillion border (020) defining the final lip height, e.g., remaining lip height after the excision of a portion of the lip located between the upper (002) and lower excision boundary (004) markers.

[0329] In certain aspects, the lower excision boundary marker (004) meets the upper excision boundary marker (002) at the lateral ends of each marker. In aspects, there is at least one detectable or significant distance between the lower (004) and upper (002) excision boundary marker(s) across the substantially horizontal span of the two markers.

[0330] In aspects, the respective point(s) establishing the lower excision boundary marker (004) corresponding to location(s) / position(s) of radial marking line(s) are each located such that use of / application of the marking system in the aesthetic procedure(s) yields target aesthetic result(s). In aspects, the individual positioning of respective point(s) according to target aesthetic result(s) provides a mechanism for customizing target aesthetic result(s) by providing for the modification of the excision height across the span of the upper (002) and lower excision boundary (004) marker(s). Modification of the excision height across the span of the upper (002) and lower excision boundary (004) marker(s) is accomplished by modifying the position of a plurality of points along the lower excision boundary marker (004) at locations ) / position(s) of radial marking lines(s), establishing the shape of the portion of the upper lip to be excised and establishing the final lip height at the location(s) / position(s) of specific radial marking line(s).

[0331] In aspects, the lower excision boundary marker (004) comprises point(s) which fall(s) along the course of each of at least 1, >~2, >~3, >~4, >~5, >~6, or >~7 radial marker(s). In aspects, as described above, the location of each such point on the upper lip, between the upper excision boundary marker (002) and the upper vermillion border (020) is established according to a target aesthetic effect (e.g., the final lip height desired / targeted at such location to achieve a target aesthetic effect). In aspects, such point(s), and thus the lower excision boundary marker (004) itself, represent(s) interim point(s) along the course of the radial marking(s) as the marking(s) span(s) from the upper excision boundary marker (002) to the upper vermillion border (020). In aspects, such a span of each radial marker is specifically marked / identified on the skin of the subject. In aspects, such a span may be broken (e.g., by the line not being indicated within the portion of the upper lip between the upper (002) and lower excision boundary (004) markers indicating the portion of the upper lip to be excised); however, the trajectory of the marker(s) is clearly indicated despite any such existing gap.Radial Markers

[0332] In aspects, the disclosure provides a marking system comprising at least one, e.g., >~2, >~3, >~4, >~5, >~6, >~7, >~8, >~9, >~10, >~11, >~12, >~13, >~I4, or, e.g., >~15 radially spaced markings (“radial markers” or “radial markings”). Typically, marking system(s) provided herein comprise at least about 7, such as >~8, >~9, >—10, >~11 , >—12, >—13, >—14, or >~15 radial markers. In certain aspects, the marking system comprises at least 7 radially spaced markings.

[0333] In aspects, marking system(s) comprise radially spaced markings identified as “primary radial marking(s)” or “p-radial marking(s)” / “p-radial marker(s).” In aspects, marking system(s) comprise both p-radial marker(s) and additional radial markers in between two or more neighboring p-radial markers identified herein as “intermediary radial marking(s)” or “i-radial marking(s).” This is described further elsewhere herein.

[0334] In aspects, radial marker(s) are at least generally vertical (e.g., ranging from vertical to more diagonal; but not characterizable as generally or substantially horizontal). In aspects, radial marker(s) span the distance between the nasal base and the upper vermillion. In aspects, radial marker(s) have a first, upper point located along an upper excision boundary marker (002) and a second, lower point located along the upper vermillion border (020). In aspects, the span of the marker is fully visible / indicated on the skin of the subject. In aspects, the span is not completely visually indicated, e.g., a break in the span of the marker is present, however, the path of the marker is clearly comprehensible given an indication of the marker being present on either side of any such gap(s). For example, in aspects, radial marker(s) have an at least first point indicated along the upper excision boundary marker (002) and indicated at / along the nasal base or nasal sill as indicated by an upper excision boundary (002) and an at least second point indicated along the upper vermillion border (020), with the trajectory of the radial marker(s) gradually radially rotating laterally toward the angle of the nasolabial fold(s) (016 A) and (016B) (respectively), following the lip’s natural relaxed tension lines, pores, or both. In aspects, at least first and second points are fully visually connected. In aspects, the visual connection between such at least first and second points is interrupted by a portion of the upper lip identified as the portion to be excised, such a segment of the radial marker(s) within such a portion of the upper lip to be excised representing the excise height at the location of such radial marker. In aspects, one or more radial marker(s) may be continuous while one or more radial marker(s) may be interrupted.

[0335] In aspects, radial marker(s) of marking system(s) provided herein each identify independent target locations within the upper lip for modification of the upper lip in an aesthetic modification procedure (e.g., an upper lip lift, e.g., a subnasal upper lip lift, e.g., a deep plane release upper lip lift procedure(s) (e.g., with or without concomitant comer lip lift(s)). In aspects, independent modifications made at the independent target locations provides one or more target aesthetic effect(s).

[0336] In aspects, each radial marker / marking comprises at least 3 distinct points within its length, wherein a first distinct point within each marks a first upper incision point along the nasal base (together serving to form an upper excision boundary marker (002)); a second distinct point within each marks a second lower incision point and helps to establish the lower excision boundary marker (004); and a third point within each located on the upper vermillion border (020). In aspects, a first upper incision point along the nasal base may mark the end of the radial marker. In aspects, the upper excision boundary marker (002) may mark the end of one or more radial marker(s). In aspects, radial marker(s) may detectably extend beyond an upper incision point along the nasal base. In aspects, radial marker(s) may extend above the upper excision boundary marker (002).

[0337] As alluded to above, in aspects, radial marking(s) are positioned between the nasal base, e.g., an upper excision boundary (002) along the nasal base, and the upper vermillion border (020). In aspects radial marking(s), e.g., at least 7 radial marking(s), progress from at least substantially vertical at the midline point of the Cupid’s bow trough with gradual rotation laterally toward the angle of the nasolabial fold(s) (016A) and (016B) (respectively). In aspects, as the set of radial marking(s) progress laterally, radial marking(s) follow(s) the upper lip’s natural relaxed tension lines, pores, or both.Radial Marking 1

[0338] In aspects, marking system(s) provided herein comprise a radial marking, e.g., a first radial marking, for ease of reference herein identified as “radial marking 1” (006), positioned in the middle of the columella and philtral dimple. In aspects, radial marking 1 (006) is positioned at the lowest point of the trough of Cupid’s bow. In aspects, radial marking 1 (006) is the most centrally located of any radial marker(s) / marking(s) present in marking system(s) provided herein. Figures 3 A and 3B illustrate an exemplary position of radial marking 1, element (006) of the figure. In aspects, radial marking 1 (006) is identified herein as a primary radial marker, e.g., a p-radial marker.

[0339] According to certain aspects, radial marking 1 (006) is an at least generally, at least substantially, at least essentially, essentially, or is a vertical marking. In aspects, as radial marker(s) progress laterally from radial marking 1 (006), they detectably or significantly rotate laterally toward the angle of the nasolabial fold(s) (016A) and (016B). Figure 2A shows the position of one end of radial marking 1 (006). Shown as a pointed “v,” such a positioning mark can be, e.g., in other aspect, indicated as a straight line). See also Figures 3 A and 3B indicating radial marker (006).

[0340] In certain aspects, radial marking 1 (006) comprises a total length, extending from the nasal base, e.g., the upper excision boundary (002), to the upper vermillion border (020). In aspects, the total length is represented by the combination of an excision height segment and a final lip height segment. In aspects, a first portion of radial marking 1 (006) comprises an excision height segment bound by the upper excision boundary marker (002) and the lower excision boundary marker (004). In aspects, the excision height segment identifies the portion of the upper lip along radial marking 1 (006) to be excised during the procedure to which the marking system is applied, e.g., an upper lip lift procedure. In aspects, a second portion of radial marking 1 (006) comprises a final lip height segment bound by the lower excision boundary marker (004) and the upper vermillion border (020). In aspects, the final lip height segment identifies the portion of the upper lip along radial marking 1 (006) which will remain postexcision.Radial Marking 1: Total Length

[0341] In aspects, the total length of radial marking 1 (006), and, similarly, in aspects one, some, most, or in aspects all other radial marking(s) described herein, is the distance between its point along the upper excision boundary marker (002) and its point along the upper vermillion border (020). In aspects, radial marking 1 (006), and similarly, in aspects, one, some, most, or in aspects all other radial marking(s) described herein, is / are not continuous. In aspects, there is a gap along the course of radial marking(s) representing the excision height at such position along its length. In aspects, as has been described, and which applies to discussion of all other marking(s) disclosed herein, the marking(s) are virtual and are element(s) of automated system(s) described herein.

[0342] In aspects, radial marking 1 (006) can have any total length (“1-T”) suitable and effective for achieving targeted aesthetic effect(s).

[0343] In aspects, radial marking 1 (006) has a total length (“1-T”) of between about 8 mm and about 20 mm, such as, e.g., ~8 mm - -19 mm, ~8 mm - ~18 mm, ~8 mm - -17 mm, -8mm - ~16 mm, ~8 mm - -15 mm, ~8 mm - -14 mm, ~8 mm - -13 mm, ~8 mm - -12 mm, ~8 mm - ~11 mm, or, e.g., ~8 mm - ~10 mm.

[0344] In aspects, radial marking 1 (006) has a total length of, e.g., -9 mm - ~20 mm, -10 mm - -20 mm, ~11 mm - ~20 mm, -12 mm - ~20 mm, -13 mm - ~20 mm, -14 mm - ~20 mm, or - 15 mm - ~20 mm.

[0345] In aspects, radial marking 1 (006) has a total length of ~8 mm - -19 mm, -9 mm - ~18 mm, -10 mm - -17 mm, ~10 mm - ~I6 mm, or, e.g., -11 mm - -15 mm, such as, e.g., ~11 mm, ~12 mm, -13 mm, ~14 mm, or, e.g., -15 mm.Radial Markins 1: Excision Height Segment Length

[0346] In aspects, radial marking 1 (006) can have any excision height segment length (“1-EX”) suitable and effective for achieving targeted aesthetic effect(s).

[0347] In aspects, radial marking 1 (006) comprises an excision height segment length (“1-EX”) of about 0 mm to about 10 mm, such as, e.g., ~0 mm - -9 mm, ~0 mm - ~8 mm, ~0 mm - -7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - -4 mm, ~0 mm - -3 mm, or, e.g., ~0 mm - -2 mm.

[0348] In aspects, radial marking 1 (006) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - ~10 mm, 7 mm - ~10 mm, 8 mm - ~10 mm, or, e.g., 9 mm - ~10 mm.

[0349] In aspects, radial marking 1 (006) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - -6 mm, -1 mm - ~8 mm, -1 mm - ~6 mm, -1 mm - ~5 mm, -1 mm - -4 mm, -2 mm - ~6 mm, -2 mm - ~5 mm, -2 mm - -4 mm, or, e.g., -1 mm - -2 mm.Radial Marking 1: Final Lip Height Segment Length

[0350] In aspects, radial marking 1 (006) can have any final lip height segment length (“1-FH”) suitable and effective for achieving targeted aesthetic effect(s).

[0351] In aspects, radial marking 1 (006) comprises a final lip height segment length (“1- FH”) of between about 1 mm - ~18 mm, such as, e.g., -1 mm - -17 mm, -1 mm - ~16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - ~12 mm, -1 mm - -11 mm, -1 mm - ~10 mm, -1 mm - ~9 mm, or, e.g., -1 mm - ~8 mm.

[0352] In aspects, radial marking 1 (006) comprises a final lip height segment length of -2 mm - ~18 mm, -3 mm - -18 mm, -4 mm - -18 mm, -5 mm - -18 mm, -6 mm - -18 mm, -7 mm - -18 mm, -8 mm - -18 mm, -9 mm - -18 mm, or, e.g., -10 mm - -18 mm.

[0353] In aspects, radial marking 1 (006) comprises a final lip height segment of -2 mm - -17 mm, ~3 mm - ~16 mm, -4 mm - -15 mm, ~5 mm - -15 mm, -6 mm - ~15 mm, -7 mm - ~15 mm, ~8 mm - ~15 mm, -9 mm - ~15 mm, ~10 mm - -14 mm, or, e.g., -11 mm - -13 mm.

[0354] In aspects, the excision height segment length is between about 8% and about 20% of the length of final lip height segment, such as, e.g., -8% - -18%, -8% - -16%, -8% - -14%, -8% - -12%, or -8% - -10% of the final lip height segment length, as in, e.g., -10% - -20%, -12% - -20%, -14% - -20%, -16% - -20% or -18% - -20% of the final lip height segment length, for example -9% - -19%, -10% - -18%, -11% - -17%, -12% - -16%, or, e.g., ~13% - ~15% of the final lip height segment length.Radial Markings 2AI2B

[0355] In aspects, marking system(s) provided herein comprise 2 radial markings, e.g., a set of paramedian markings, for ease of reference herein identified as “radial marking 2A” (or radial marker 2A or radial indicator 2A) (008A) and “radial marking 2B,” (or radial marker 2B or radial indicator 2B) (008B) positioned lateral to and on either side of the columella. In aspects, radial marking lines 2A (008A) and 2B (008B) are located at the peaks of Cupid’s bow. In aspects, radial marking lines 2A (008A) and 2B (008B) are located at the point where the medial crural footplates diverge into the nose at the junction with the alar sill. In aspects, radial marking(s) 2A (008A) and 2B (008B) are characterizable as paramedian lines or philtral lines due to their anatomical positioning. Figures 3A and 3B illustrate an exemplary position of radial markings 2A (008A) and 2B (008B), identified as element (008) in the figure, e.g., one of radial marking 2A (008A) or 2B (008B) wherein the other is the corresponding marker on the opposite side of the face. In aspects, radial marking(s) 2A (008A), 2B (008B), or both is / are identified herein as primary radial marker(s), e.g., p-radial marker(s). Figure 2A shows the position of at least one end of radial markers 2A (008A) and 2B (008B), respectively. See the location of radial marking(s) 2A (008A) and 2B (008B) also in, e.g., Figures 3A and 3B.

[0356] In certain aspects only one of radial marking lines 2A (008A) and 2B (008B) may be present in a marking system. Typically, a marking system will comprise both radial marking 2A (008A) and radial marking 2B (008B).

[0357] According to certain aspects, radial marking(s) 2 A (008 A) and 2B (008B) are each at least generally, at least substantially, at least essentially, or essentially vertical marking(s). In aspects, as radial marker(s) 2A (008A) and 2B (008B) are positioned laterally to radial marking 1 (006), each of radial marker 2A (008A) and 2B (008B) may detectably or significantly rotate laterally toward the angle of the nasolabial fold(s) (016A) and (016B),respectively. In aspects, the lateral rotation of radial marker(s) 2A (008A) and 2B (008B) is detectably or significantly greater than that of radial marker 1 (006) but delectably or significantly less than that of one or more of radial markers 3A (010A), 3B (010B), 4A (012A), 4B (012B), 5A (014A), 5B (014B), including combination(s) of any or all thereof.

[0358] In certain aspects, radial markings 2A (008A), 2B (008B), or both comprise(s) a total length, extending from the nasal base, e.g., upper excision boundary (002), to the upper vermillion border (020). In aspects, the total length is represented by the combination of an excision height segment and a final lip height segment. In aspects, a first portion of radial marking(s) 2A (008A), 2B (008B), or both comprise(s) an excision height segment bound by the upper excision boundary marker (002) and the lower excision boundary marker (004). In aspects, the excision height segment identifies the portion of the upper lip along radial marking 1 (006) to be excised during the procedure to which the marking system is applied, e.g., an upper lip lift procedure. In aspects, a second portion of radial marking(s) 2A (008A), 2B (008B), or both comprise(s) a final lip height segment bound by the lower excision boundary marker (004) and the upper vermillion border (020). In aspects, the final lip height segment identifies the portion of the upper lip along radial marking(s) 2A (008A), 2B (008B), or both which will remain postexcision.Radial Markings 2A / 2B: Total Length

[0359] In aspects, radial marking 2A (008A), radial marking 2B (008B), or both can have any total length (“2A-T” and “2B-T”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0360] In aspects, radial marking 2A (008A) has a total length (“2A-T”) of between about 8 mm and about 20 mm, such as, e.g., ~8 mm - -19 mm, -8 mm - -18 mm, -8 mm - -17 mm, -8 mm - -16 mm, -8 mm - -15 mm, -8 mm - -14 mm, -8 mm - -13 mm, -8 mm - -12 mm, -8 mm - -11 mm, or, e.g., -8 mm - -10 mm.

[0361] In aspects, radial marking 2A (008A) has a total length of, e.g., -9 mm - -20 mm, -10 mm - -20 mm, -11 mm - -20 mm, -12 mm - -20 mm, -13 mm - -20 mm, -14 mm - -20 mm, or -15 mm - -20 mm.

[0362] In aspects, radial marking 2A (008A) has a total length of -8 mm - -19 mm, -9 mm - -18 mm, -10 mm - -17 mm, -10 mm - -16 mm, or, e.g., -11 mm - -15 mm, such as, e.g., -11 mm, -12 mm, -13 mm, -14 mm, or, e.g., -15 mm.

[0363] In aspects, radial marking 2B (008B) has a total length (“2B-T”) of between about 8 mm and about 20 mm, such as, e.g., -8 mm - -19 mm, -8 mm - -18 mm, -8 mm - -17 mm,~8 mm - ~16 mm, ~8 mm - ~15 mm, ~8 mm - ~14 mm, ~8 mm - ~13 mm, ~8 mm - ~12 mm, ~8 mm - ~11 mm, or, e.g., ~8 mm - ~10 mm.

[0364] In aspects, radial marking 2B (008B) has a total length of, e.g., ~9 mm - ~20 mm, ~10 mm - ~20 mm, ~11 mm - ~20 mm, ~12 mm - ~20 mm, ~13 mm - ~20 mm, ~14 mm - ~20 mm, or ~ 15 mm - ~20 mm.

[0365] In aspects, radial marking 2B (008B) has a total length of ~8 mm - ~19 mm, ~9 mm - ~18 mm, ~10 mm - ~17 mm, ~I0 mm - ~I6 mm, or, e.g., ~11 mm - ~15 mm, such as, e.g., ~11 mm, ~12 mm, ~13 mm, ~14 mm, or, e.g., ~15 mm.Radial Markings 2A / 2B: Excision Height Segment Length

[0366] In aspects, radial marking 2A (008A), radial marking 2B (008B), or both can have any excision height segment length (“2A-EX” and “2B-EX”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0367] In aspects, radial marking 2A (008A) comprises an excision height segment length (“2A-EX”) of about 0 mm to about 10 mm, such as, e.g., ~0 mm - ~9 mm, ~0 mm - ~8 mm, ~0 mm - ~7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - ~4 mm, ~0 mm - ~3 mm, or, e.g., ~0 mm - ~2 mm.

[0368] In aspects, radial marking 2A (008A) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - ~10 mm, 7 mm - ~10 mm, 8 mm - ~10 mm, or, e.g., 9 mm - ~10 mm.

[0369] In aspects, radial marking 2A (008A) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - ~6 mm, ~1 mm - ~8 mm, ~1 mm - ~6 mm, ~1 mm - ~5 mm, ~1 mm - ~4 mm, ~2 mm - ~6 mm, ~2 mm - ~5 mm, ~2 mm - ~4 mm, or, e.g., ~1 mm - ~2 mm.

[0370] In aspects, radial marking 2B (008B) comprises an excision height segment length (“2B-EX”) of about 0 mm to about 10 mm, such as, e.g., ~0 mm - ~9 mm, ~0 mm - ~8 mm, ~0 mm - ~7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - ~4 mm, ~0 mm - ~3 mm, or, e.g., ~0 mm - ~2 mm.

[0371] In aspects, radial marking 2B (008B) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - ~10 mm, 7 mm - ~10 mm, 8 mm - ~10 mm, or, e.g., 9 mm - ~10 mm.

[0372] In aspects, radial marking 2B (008B) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - ~6 mm, ~1 mm - ~8 mm, ~1 mm - ~6 mm, ~1 mm - ~5mm, -1 mm - -4 mm, -2 mm - ~6 mm, -2 mm - ~5 mm, -2 mm - -4 mm, or, e.g., -1 mm - -2 mm.Radial Markings 2A / 2B: Final Lip Height Segment Length

[0373] In aspects, radial marking 2A (008A), radial marking 2B (008B), or both can have any final lip heigh segment length (“2A-FH” and “2B-FH”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0374] In aspects, radial marking 2A (008A) comprises a final lip height segment length (“2A-FH”) of between about 1 mm - ~18 mm, such as, e.g., -1 mm - -17 mm, -1 mm - ~16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - ~12 mm, -1 mm - ~11 mm, -1 mm - ~10 mm, -1 mm - -9 mm, or, e.g., -1 mm - ~8 mm.

[0375] In aspects, radial marking 2A (008A) comprises a final lip height segment length of -2 mm - ~18 mm, ~3 mm - ~18 mm, -4 mm - ~18 mm, ~5 mm - ~18 mm, -6 mm - ~18 mm, -7 mm - ~I8 mm, ~8 mm - ~18 mm, -9 mm - ~18 mm, or, e.g., ~I0 mm - ~I8 mm.

[0376] In aspects, radial marking 2A (008A) comprises a final lip height segment of -2 mm - -17 mm, -3 mm - -16 mm, -4 mm - -15 mm, -5 mm - -15 mm, -6 mm - -15 mm, -7 mm - -15 mm, -8 mm - -15 mm, -9 mm - -15 mm, -10 mm - -14 mm, or, e.g., -11 mm - -13 mm.

[0377] In aspects, radial marking 2B (008B) comprises a final lip height segment length (“2B-FH”) of between about 1 mm - -18 mm, such as, e.g., -1 mm - -17 mm, -1 mm - -16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - -12 mm, -1 mm - -11 mm, -1 mm - -10 mm, -1 mm - -9 mm, or, e.g., -1 mm - -8 mm.

[0378] In aspects, radial marking 2B (008B) comprises a final lip height segment length of -2 mm - -18 mm, -3 mm - -18 mm, -4 mm - -18 mm, -5 mm - -18 mm, -6 mm - -18 mm, -7 mm - -18 mm, -8 mm - -18 mm, -9 mm - -18 mm, or, e.g., -10 mm - -18 mm.

[0379] In aspects, radial marking 2B (008B) comprises a final lip height segment of -2 mm - -17 mm, -3 mm - -16 mm, -4 mm - -15 mm, -5 mm - -15 mm, -6 mm - -15 mm, -7 mm - -15 mm, -8 mm - -15 mm, -9 mm - -15 mm, -10 mm - -14 mm, or, e.g., -11 mm - -13 mm.

[0380] In aspects, the excision height segment length of radial marking 2A, radial marking 2B, or both radial markings 2A and 2B is / are between about 8% and about 20% of the length of final lip height segment of the same radial marking, such as, e.g., -8% - - 18%, -8% - -16%, -8% - -14%, -8% - -12%, or -8% - -10% of the final lip height segment length of the same radial marking, as in, e.g., -10% - -20%, -12% - -20%, -14% - -20%, -16% - -20% or-18% - -20% of the final lip height segment length, for example -9% - -19%, -10% - -18%, -11% - -17%, -12% - -16%, or, e.g., -13% - -15% of the final lip height segment length of the same radial marking.

[0381] In aspects, the final lip height segment length of radial marking 2A (008A) is at least generally, at least substantially, at least essentially, is essentially, or is the same as the final lip height segment length of radial marking 2B, and vice-versa. In aspects, the final lip height segment of radial marking 2A (008 A), radial marking 2B (008B), or both, is / are at least generally, at least substantially, at least essentially, is / are essentially, or is / are the same as the final lip height segment of radial marking 1. In aspects, the final lip height segment of two or more of radial markings 2A (008A), 2B (008B), and radial marking 1 (006) are within about 20%, or within -15%, -10%, -9%, -8%, -7%, -6%, -5%, -4%, -3%, -2%, -1%, or within -0.5% or -0.1% of the final lip height segment of one or more another of radial markings 2A (008A, 2B (008B, and radial marking 1 (006).Radial Markings 3A / 3B

[0382] In aspects, marking system(s) provided herein comprise 2 radial markings, for ease of reference herein identified as “radial marking 3 A” (010A) and “radial marking 3B” (010B), positioned lateral to each of radial markings 2A (008A) and 2B (008B), respectively. In aspects, radial markings 3A (010A) and 3B (010B) are positioned intermedially, e.g., centrally, between radial markings 2A (008A) and 4A (012A) and between radial markings 2B (008B) and 4B (012B), respectively. Figures 3 A and 3B illustrate an exemplary position of radial markings 3A (010A) and 3B (010B), identified as elements (010A) and (010B), respectively. In aspects, radial marking(s) 3A (010A), 3B (010B), or both is / are identified herein as primary radial marker(s), e.g., p-radial marker(s). In certain aspect(s) of method(s) herein describing the formation of such marking system(s) described here, a portion or all of each of radial marking(s) 3A (010A), 3B (010B), or both is / are not made until a portion or all of each of radial markings 2 (e.g., 2A (008A), 2B (008B) or both) and 4 (e.g., 4A (012A), 4B (012B), or both) are established.

[0383] In certain aspects only one of radial marking lines 3A (010A) and 3B (010B) are present in a marking system. Typically, a marking system will comprise both radial marking 3A (010 A) and radial marking 3 B (010B).

[0384] According to certain aspects, radial marking(s) 3A (010A) and 3B (010B) are detectably or significantly non-vertical. In aspects, radial marker(s) 3A (010A) and 3B (010B) are positioned laterally to radial marking 1 (006) and radial marking(s) 2A (008A) and 2B(008B), and each of radial marker 3A (010A) and 3B (010B) may detectably or significantly rotate laterally toward the angle of the nasolabial fold(s) (016A) and (016B), respectively. In aspects, the lateral rotation of radial marker(s) 3 A (01 OA) and 3B (01 OB) is detectably or significantly greater than that of radial marker 1 (006), radial marker 2A (008A), radial marker 2B (008B), or a combination thereof, but detectably or significantly less than that of one or more of radial markers 4A (012A), 4B (012B), 5A (014A), 5B (014B), including combination(s) of any or all thereof.

[0385] In certain aspects, radial markings 3A (010A), 3B (010B), or both comprise(s) a total length, extending from the nasal base (e.g., as indicated by the upper excision boundary (002) to the upper vermillion border (020). In aspects, the total length is represented by the combination of an excision height segment and a final lip height segment. In aspects, a first portion of radial marking(s) 3A (010A), 3B (010B), or both comprise(s) an excision height segment bound by the upper excision boundary marker (002) and the lower excision boundary marker (004). In aspects, the excision height segment identifies the portion of the upper lip along radial marking 3 A (010 A) or radial marking 3B (010B) to be excised during the procedure to which the marking system is applied, e.g., an upper lip lift procedure. In aspects, a second portion of radial marking(s) 3A (010A), 3B (010B), or both comprise(s) a final lip height segment bound by the lower excision boundary marker (004) and the upper vermillion border (020). In aspects, the final lip height segment identifies the portion of the upper lip along radial marking(s) 3A (010A), 3B (010B), or both which will remain post-excision.Radial Markings 3A / 3B: Total Length

[0386] In aspects, radial marking 3A (010A), radial marking 3B (010B), or both can have any final length (“3A-T” and “3B-T”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0387] hi aspects, radial marking 3A (010A) has a total length (“3A-T”) of between about 8 mm and about 24 mm, such as, e.g., ~8 mm - ~23 mm, ~8 mm - -22 mm, ~8 mm - ~21 mm, ~8 mm - ~20 mm, ~8 mm - -19 mm, ~8 mm - ~18 mm, ~8 mm - -17 mm, ~8 mm - ~16 mm, ~8 mm - -15 mm, ~8 mm - 14 mm, -8 mm - -13 mm, -8 mm - -12 mm, -8 mm - -11 mm, or, e.g., -8 mm - -10 mm.

[0388] In aspects, radial marking 3A (010A) has a total length of, e.g., -9 mm - -24 mm, -10 mm - -24 mm, -11 mm - -24 mm, -12 mm - -24 mm, -13 mm - -24 mm, -14 mm - -24 mm, -15 mm - -24 mm, -16 mm - -24 mm, -17 mm - -24 mm, or -18 mm - -24 mm.

[0389] In aspects, radial marking 3A (010A) has a total length of ~8 mm - ~23 mm, ~9 mm - -22 mm, ~10 mm - ~21 mm, ~11 mm - ~20 mm, ~11 mm - ~18 mm, ~11 mm - ~16 mm, or, e.g., ~11 mm - -15 mm, such as, e.g., ~11 mm, ~12 mm, -13 mm, -14 mm, -15 mm, ~16 mm, -17 mm, or, e.g., ~18 mm.

[0390] In aspects, radial marking 3B (010B) has a total length (“3B-T”) of between about 8 mm and about 24 mm, such as, e.g., ~8 mm - ~23 mm, ~8 mm - -22 mm, ~8 mm - ~21 mm, ~8 mm - ~20 mm, ~8 mm - -19 mm, ~8 mm - ~18 mm, ~8 mm - -17 mm, ~8 mm - ~16 mm, ~8 mm - -15 mm, ~8 mm - ~14 mm, ~8 mm - -13 mm, ~8 mm - ~12 mm, ~8 mm - ~11 mm, or, e.g., ~8 mm - -10 mm.

[0391] In aspects, radial marking 3B (010B) has a total length of, e.g., -9 mm - ~24 mm, ~10 mm - ~24 mm, ~11 mm - ~24 mm, ~12 mm - ~24 mm, -13 mm - ~24 mm, -14 mm - ~24 mm, -15 mm - ~24 mm, ~16 mm - ~24 mm, -17 mm - ~24 mm, or ~18 mm - ~24 mm.

[0392] In aspects, radial marking 3B (010B) has a total length of ~8 mm - ~23 mm, -9 mm - -22 mm, ~10 mm - ~21 mm, -11 mm - ~20 mm, -11 mm - ~18 mm, -11 mm - -16 mm, or, e.g., -11 mm - -15 mm, such as, e.g., ~11 mm, ~12 mm, -13 mm, -14 mm, -15 mm, ~16 mm, ~18 mm, or, e.g., ~18 mm.Radial Markings 3A / 3B: Excision Height Segment Length

[0393] In aspects, radial marking 3A (010A), radial marking 3B (010B), or both can have any excision height segment length (“3A-EX” and “3B-EX”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0394] In aspects, radial marking 3A (010A) comprises an excision height segment length (“3A-EX”) of about 0 mm to about 10 mm, such as, e.g., ~0 mm - -9 mm, ~0 mm - ~8 mm, -0 mm - -7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - -4 mm, ~0 mm - -3 mm, or -0 mm - -2 mm.

[0395] hi aspects, radial marking 3A (010A) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - ~10 mm, 7 mm - ~10 mm, 8 mm - ~10 mm, or 9 mm - ~10 mm.

[0396] In aspects, radial marking 3A (010A) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - -6 mm, -1 mm - ~8 mm, -1 mm - ~6 mm, -1 mm - ~5 mm, -1 mm - -4 mm, -2 mm - ~6 mm, -2 mm - ~5 mm, -2 mm - -4 mm, or -1 mm - -2 mm.

[0397] In aspects, radial marking 3B (010B) comprises an excision height segment length (“3B-EX”) of about 0 mm to about 10 mm, such as, e.g., ~0 mm - -9 mm, ~0 mm - ~8mm, -0 mm - -7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - -4 mm, ~0 mm - ~3 mm, or -0 mm - -2 mm.

[0398] In aspects, radial marking 3B (010B) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - -10 mm, 7 mm - -10 mm, 8 mm - -10 mm, or 9 mm - -10 mm.

[0399] In aspects, radial marking 3B (010B) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - -6 mm, -1 mm - ~8 mm, -1 mm - ~6 mm, -1 mm - ~5 mm, -1 mm - -4 mm, -2 mm - ~6 mm, -2 mm - ~5 mm, -2 mm - -4 mm, or -1 mm - -2 mm.

[0400] Radial Markings 3A / 3B: Final Liy Height Segment Length

[0401] In aspects, radial marking 3A (010A), radial marking 3B (010B), or both can have any final lip height segment length (“3A-FH” and “3B-FH”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0402] In aspects, radial marking 3 A (010 A) comprises a final lip height segment length (“3A-FH”) of between about 1 mm - -19 mm, such as, e.g., -1 mm - -18 mm, -1 mm - -17 mm, -1 mm - -16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - -12 mm, -1 mm - -11 mm, -1 mm - -10 mm, -1 mm - -9 mm, or, e.g., -1 mm - -8 mm.

[0403] In aspects, radial marking 3A (010A) comprises a final lip height segment length of -2 mm - -19 mm, -3 mm - -19 mm, -4 mm - -19 mm, -5 mm - -19 mm, -6 mm - -19 mm, -7 mm - -19 mm, -8 mm - -19 mm, -9 mm - -19 mm, -10 mm - -19 mm, -11 mm - -19 mm, or, e.g., -12 mm - -19 mm.

[0404] In aspects, radial marking 3A (010A) comprises a final lip height segment of -2 mm - -18 mm, -3 mm - -17 mm, -4 mm - -16 mm, -5 mm - -15 mm, -6 mm - -15 mm, -7 mm - -15 mm, -8 mm - -15 mm, -9 mm - -15 mm, -10 mm - -14 mm, or, e.g., -12 mm - -16 mm.

[0405] In aspects, radial marking 3B (010B) comprises a final lip height segment length (“3B-FH”) of between about 1 mm - -19 mm, such as, e.g., -1 mm - -18 mm, -1 mm - -17 mm, -1 mm - -16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - -12 mm, -1 mm - -11 mm, -1 mm - -10 mm, -1 mm - -9 mm, or, e.g., -1 mm - -8 mm.

[0406] In aspects, radial marking 3B (010B) comprises a final lip height segment length of -2 mm - -19 mm, -3 mm - -19 mm, -4 mm - -19 mm, -5 mm - -19 mm, -6 mm - -19 mm, -7 mm - -19 mm, -8 mm - -19 mm, -9 mm - -19 mm, -10 mm - -19 mm, -1 1 mm - -19 mm, or, e.g., -12 mm - -19 mm.

[0407] In aspects, radial marking 3B (010B) comprises a final lip height segment of -2 mm - ~18 mm, ~3 mm - -17 mm, -4 mm - ~16 mm, ~5 mm - -15 mm, -6 mm - -15 mm, -7 mm - -15 mm, ~8 mm - -15 mm, -9 mm - -15 mm, ~10 mm - -14 mm, or, e.g., ~12 mm - ~16 mm.

[0408] In aspects, the excision height segment length of radial marking 3A (010A), radial marking 3B (010B), or both radial markings 3A (010A) and 3B (010B) is / are between about 8% and about 20% of the length of final lip height segment of the same radial marking, such as, e.g., -8% - -18%, -8% - -16%, -8% - -14%, -8% - -12%, or -8% - -10% of the final lip height segment length of the same radial marking, as in, e.g., -10% - -20%, -12% - -20%, -14% - -20%, -16% - -20% or -18% - -20% of the final lip height segment length, for example -9% - -19%, -10% - -18%, -11% - -17%, -12% - -16%, or, e.g., -13% - -15% of the final lip height segment length of the same radial marking.Radial Markings 4A / 4B

[0409] In aspects, marking system(s) provided herein comprise 2 radial markings, e.g., a set of radial markings, for ease of reference herein identified as “radial marking 4A“ (012A) and “radial marking 4B” (012B), positioned lateral to each of radial markings 3A (010A) and 3B (010B), respectively. In aspects, radial markings 4A (012A) and 4B (012B) each respectively begin at the internal angle of the alar recurvature and extend radially downward. In aspects, radial markings 4A (012A) and 4B (012B) each respectively follow the natural curvature of the upper lip. In aspects, radial markings 4 A (012A) and 4B (012B) each respectively follow the natural tension line(s) of the upper lip. In aspects, radial markings 4A (012A) and 4B (012B) each respectively follow the radial angulation of the pores of the upper lip. In aspects, radial markings 4A (012A) and 4B (012B) each respectively follow the natural curvature of the upper lip, following the natural tension line(s) and the radial angulation of the pores of the upper lip. Figures 3A and 3B illustrate an exemplary position of radial markings 4A (012A) and 4B (012B), identified as elements (012A) and (012B) in the figure, e.g., one of radial marking 4A (012A) or 4B (012B) wherein the other is the corresponding marker on the opposite side of the face. In aspects, radial marking(s) 4A (012A), 4B (012B), or both is / are identified herein as primary radial marker(s), e.g., p-radial marker(s). Radial markings 4A (012A) and 4B (012B) are illustrated in, e.g., Figure 2A of the figures provided herewith. See also, e.g., Figures 3A and 3B.

[0410] In aspects, radial markings 4A (012A) and 4B (012B) each respectively mark a border between a first region of the upper lip identified as the subnasal lip as it transitions to asecond region of the upper lip identified as the subfacial lip and lateral mouth. This is discussed further elsewhere herein. In aspects, radial markings 4 A (012A) and 4B (012B) delineate where the effect of the lifting of an upper lip lift procedure, e.g., a deep plane upper lip lift procedures, on the lateral lip will detectably or significantly taper.

[0411] In certain aspects only one of radial marking lines 4A (012 A) and 4B (012B) may be present in a marking system. Typically, a marking system will comprise both radial marking 4A (012A) and radial marking 4B (012B).

[0412] According to certain aspects, radial marking(s) 4A (012A) and 4B (012B) are detectably or significantly non- vertical. In aspects, radial marker(s) 4A (012A) and 4B (012B) are positioned laterally to radial markings 1, 2A (008A), 2B (008B), 3A (010A), and 3B (010B) (respectively), and each of radial marker 4A (012A) and 4B (012B) may detectably or significantly rotate laterally toward the angle of the nasolabial fold(s) (016A) and (016B), respectively. In aspects, the lateral rotation of radial marker(s) 4A (012A) and 4B (012B) is detectably or significantly greater than that of radial marker 1 (006), radial marker 2A (008A), radial marker 2B (008B), radial marker 3A (010A), radial marker 3B (010B), or a combination thereof, but detectably or significantly less than that of one or more of radial markers 5 A (014A) or 5B (014B) or both.

[0413] In certain aspects, radial markings 4A (012A), 4B (012B), or both comprise(s) a total length, extending from the nasal base, e.g., from the upper excision boundary (002) to the upper vermillion border (020). In aspects, the total length is represented by the combination of an excision height segment and a final lip height segment. In aspects, a first portion of radial marking(s) 4A (012A), 4B (012B), or both comprise(s) an excision height segment bound by the upper excision boundary marker (002) and the lower excision boundary marker (004). In aspects, the excision height segment identifies the portion of the upper lip along radial marking 4A (012A) or radial marking 4B (012B) to be excised during the procedure to which the marking system is applied, e.g., an upper lip lift procedure. In aspects, a second portion of radial marking(s) 4A (012A), 4B (012B), or both comprise(s) a final lip height segment bound by the lower excision boundary marker (004) and the upper vermillion border (020). In aspects, the final lip height segment identifies the portion of the upper lip along radial marking(s) 4A (012A), 4B (012B), or both which will remain post-excision.Radial Markings 4A / 4B: Total Length

[0414] In aspects, radial marking 4A (012A), radial marking 4B (012B), or both can have any total length (“4A-T” and “4B-T”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0415] In aspects, radial marking 4A (012A) has a total length (“4A-T”) of between about 10 mm and about 26 mm, such as, e.g., -10 mm - ~25 mm, ~10 mm - ~24 mm, ~10 mm - ~23 mm, ~10 mm - -22 mm, ~10 mm - ~21 mm, ~10 mm - -20 mm, -10 mm - -19 mm, -10 mm - -18 mm, -10 mm - -17 mm, -10 mm - -16 mm, -10 mm - -15 mm, -10 mm - -14 mm, -10 mm - -13 mm, or, e.g., -10 mm - -12 mm.

[0416] In aspects, radial marking 4A (012A) has a total length of, e.g., -11 mm - -26 mm, -12 mm - -26 mm, -13 mm - -26 mm, -14 mm - -26 mm, -15 mm - -26 mm, -16 mm - -26 mm, -17 mm - -26 mm, -18 mm - -26 mm, -19 mm - -26 mm, or -20 mm - -26 mm.

[0417] In aspects, radial marking 4A (012A) has a total length of -11 mm - -25 mm, -12 mm - -24 mm, -13 mm - -22 mm, -14 mm - -21 mm, -15 mm - -20 mm, or, e.g., -15 mm - -19 mm, such as, e.g., -12 mm, -13 mm, -14 mm, -15 mm, -16 mm, -17 mm, -18 mm, or, e.g., -19 mm or -20 mm.

[0418] In aspects, radial marking 4B (012B) has a total length (“4B-T”) of between about 10 mm and about 26 mm, such as, e.g., -10 mm - -25 mm, -10 mm - -24 mm, -10 mm - -23 mm, -10 mm - -22 mm, -10 mm - -21 mm, -10 mm - -20 mm, -10 mm - -19 mm, -10 mm - -18 mm, -10 mm - -17 mm, -10 mm - -16 mm, -10 mm - -15 mm, -10 mm - -14 mm, -10 mm - -13 mm, or, e.g., -10 mm - -12 mm.

[0419] In aspects, radial marking 4B (012B) has a total length of, e.g., -1 1 mm - -26 mm, -12 mm - -26 mm, -13 mm - -26 mm, -14 mm - -26 mm, -15 mm - -26 mm, -16 mm - -26 mm, -17 mm - -26 mm, -18 mm - -26 mm, -19 mm - -26 mm, or -20 mm - -26 mm.

[0420] In aspects, radial marking 4B (012B) has a total length of -11 mm - -25 mm, -12 mm - -24 mm, -13 mm - -22 mm, -14 mm - -21 mm, -15 mm - -20 mm, or, e.g., -15 mm - -19 mm, such as, e.g., -12 mm, -13 mm, -14 mm, -15 mm, -16 mm, -17 mm, -18 mm, or, e.g., -19 mm or -20 mm.Radial Markings 4A / 4B: Excision Height Segment Length

[0421] In aspects, radial marking 4A (012A), radial marking 4B (012B), or both can have any excision height segment length (“4A-EX” and “4B-EX”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0422] In aspects, radial marking 4A (012A) comprises an excision height segment length (“4A-EX”) of about 0 mm to about 10 mm, such as, e.g., -0 mm - -9 mm, -0 mm - -8mm, ~0 mm - ~7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - ~4 mm, ~0 mm - ~3 mm, or ~0 mm - -2 mm.

[0423] In aspects, radial marking 4A (012A) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - ~10 mm, 7 mm - ~10 mm, 8 mm - ~10 mm, or 9 mm - ~10 mm.

[0424] In aspects, radial marking 4A (012A) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - ~6 mm, ~I mm - ~8 mm, ~1 mm - ~6 mm, ~1 mm - ~5 mm, ~1 mm - ~4 mm, ~2 mm - ~6 mm, -2 mm - ~5 mm, -2 mm - ~4 mm, or ~1 mm - -2 mm.

[0425] In aspects, radial marking 4B (012B) comprises an excision height segment length (“4B-EX”) of about 0 mm to about 10 mm, such as, e.g., ~0 mm - ~9 mm, ~0 mm - ~8 mm, ~0 mm - ~7 mm, ~0 mm - ~6 mm, ~0 mm - ~5 mm, ~0 mm - -4 mm, ~0 mm - ~3 mm, or ~0 mm - ~2 mm.

[0426] In aspects, radial marking 4B (012B) comprises an excision height segment length of about 1 mm - ~10 mm, 2 mm - ~10 mm, 3 mm - ~10 mm, 4 mm - ~10 mm, 5 mm - ~10 mm, 6 mm - ~10 mm, 7 mm - ~10 mm, 8 mm - ~10 mm, or 9 mm - -10 mm.

[0427] In aspects, radial marking 4B (012B) comprises an excision height segment length of about 0 mm - ~8 mm, ~0 mm - ~6 mm, -1 mm - ~8 mm, -1 mm - ~6 mm, -1 mm - ~5 mm, -1 mm - -4 mm, -2 mm - -6 mm, -2 mm - ~5 mm, -2 mm - -4 mm, or -1 mm - -2 mm.Radial Markings 4A / 4B: Final Lip Height Segment Length

[0428] In aspects, radial marking 4A (012A), radial marking 4B (012B), or both can have any final lip height segment length (“4A-FH” and “4B-FH”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0429] In aspects, radial marking 4A (012A) comprises a final lip height segment length (“4A-FH”) of between about 1 mm - -19 mm, such as, e.g., -1 mm - ~18 mm, -1 mm - -17 mm, -1 mm - ~16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - ~12 mm, -1 mm - ~ 11 mm, - 1 mm - ~ 10 mm, - 1 mm - -9 mm, or, e.g., - 1 mm - ~8 mm.

[0430] In aspects, radial marking 4A (012A) comprises a final lip height segment length of -2 mm - -19 mm, ~3 mm - -19 mm, -4 mm - -19 mm, ~5 mm - -19 mm, ~6 mm - -19 mm, -7 mm - -19 mm, ~8 mm - -19 mm, -9 mm - -19 mm, -10 mm - -19 mm, -11 mm - -19 mm, or, e.g., ~12 mm - -19 mm.

[0431] In aspects, radial marking 4A (012A) comprises a final lip height segment of -2 mm - ~18 mm, ~3 mm - -17 mm, -4 mm - ~16 mm, ~5 mm - -15 mm, ~6 mm - -15 mm, -7mm - -15 mm, ~8 mm - -15 mm, -9 mm - -15 mm, -10 mm - -14 mm, or, e.g., ~12 mm - —18, e.g., -14 mm - ~18 mm.

[0432] In aspects, radial marking 4B (012B) comprises a final lip height segment length (“4B-FH”) of between about 1 mm - -19 mm, such as, e.g., -1 mm - ~18 mm, -1 mm - -17 mm, -1 mm - ~16 mm, -1 mm - -15 mm, -1 mm - ~14 mm, -1 mm - -13 mm, -1 mm - ~12 mm, -1 mm - ~11 mm, -1 mm - ~10 mm, -1 mm - -9 mm, or, e.g., -1 mm - ~8 mm.

[0433] In aspects, radial marking 4B (012B) comprises a final lip height segment length of -2 mm - -19 mm, ~3 mm - -19 mm, -4 mm - -19 mm, ~5 mm - -19 mm, -6 mm - -19 mm, -7 mm - -19 mm, ~8 mm - -19 mm, -9 mm - -19 mm, -10 mm - -19 mm, -11 mm - -19 mm, or, e.g., -12 mm - -19 mm.

[0434] In aspects, radial marking 4B (012B) comprises a final lip height segment of -2 mm - -18 mm, -3 mm - -17 mm, -4 mm - -16 mm, -5 mm - -15 mm, -6 mm - -15 mm, -7 mm - -15 mm, -8 mm - -15 mm, -9 mm - -15 mm, -10 mm - -14 mm, or, e.g., -12 mm - -18, e.g., -14 mm - -18 mm.

[0435] In aspects, the excision height segment length of radial marking 4A (012A), radial marking 4B (012B), or both radial markings 4A (012A) and 4B (012B) is / are between about 8% and about 20% of the length of final lip height segment of the same radial marking, such as, e.g., -8% - -18%, -8% - -16%, -8% - -14%, -8% - -12%, or -8% - -10% of the final lip height segment length of the same radial marking, as in, e.g., -10% - -20%, -12% - -20%, -14% - -20%, -16% - -20% or -18% - -20% of the final lip height segment length, for example -9% - -19%, -10% - -18%, -1 1% - -17%, -12% - -16%, or, e.g., -13% - -15% of the final lip height segment length of the same radial marking.Radial Markings 5A / 5B

[0436] In aspects, marking system(s) provided herein comprise 2 radial markings, e.g., a set of outer radial markings (e.g., most lateral marking(s) of the radial marking(s) of marking system(s) provided herein), for ease of reference herein identified as “radial marking 5A” (014A) and “radial marking 5B” (0146), positioned lateral to each of radial markings 4A (012A) and 4B (012B), respectively. In aspects, radial markings 5A (014A) and 5B (014B) each respectively follow each of the relaxed skin tension lines (RSTLs). In aspects, radial markings 5A (014A) and 5B (014B), respectively, extend downward from the apex of the lateral end of the upper excision boundary marker (002) to be made at the nasal base. Figures 3A and 3B illustrates an exemplary position of radial markings 5 A (014A) and 5B (0146), Note that the figure further identifies the nasolabial fold(s) (016A) and (016B). In aspects, radial marking(s) 5A (014A), 5B (014B), orboth is / are identified herein as primary radial marker(s), e.g., p-radial marker(s). Radial markers 5A (014A) and 5B (014B) are provided in, e.g., Figure 21 of the figure(s) provided herewith. See also, e.g., Figure(s) 3A and 3B.

[0437] In certain aspects only one of radial marking lines 5 A (014 A) and 5B (014B) may be present in a marking system. Typically, a marking system will comprise both radial marking 5A (014A) and radial marking 5B (014B).

[0438] According to certain aspects, radial marking(s) 5 A (014A) and 5B (014B) are detectably or significantly non- vertical or comprise at least one portion which is delectably or significantly non- vertical. In aspects, radial marking(s) 5A (014A) and 5B (014B) comprise at least a portion of their length which is at least generally, is at least substantially, is at least essentially, is essentially, or is vertical. In aspects, radial marking(s) 5A (014A) and 5B (014B) comprise at least a portion of their length which is at least generally, is at least substantially, is at least essentially, is essentially, or is vertical while also comprising a portion of their length which is detectably or significantly non-vertical. In aspects, radial marker(s) 5A (014A) and 5B (0146) are positioned laterally to radial markings 1, 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), and 4B (012B) (respectively), and each of radial marker 5A (014A) and 5B (014B), or at least a portion thereof, respectively, may detectably or significantly rotate laterally toward the angle of the nasolabial fold(s) (016A) and (016B), respectively. See, e.g., Figure 2J wherein nasolabial fold(s) (016A) and (016B) are identified. See also, e.g., Figures 3A and 3B. In aspects, the lateral rotation of radial marker(s) 5A (014A) and 5B (014B) is detectably or significantly greater than that of radial marker 1 (006), radial marker 2A (008A), radial marker 2B (008B), radial marker 3A (010A), radial marker 3B (010B), radial marker 4A (012A), radial marker 4B (012B), or a combination thereof. In aspects a portion of the upper lip height segment of radial marker 5A (014A), 5B (014B), or both is at least generally, is at least substantially, is at least essentially, is essentially, or is vertical. In aspects, a portion of radial segment 5A (014A), 5B (014B), or both spanning a portion of the upper lip to be excised (excised height segment) is detectably or significantly non-vertical.

[0439] In certain aspects, radial markings 5A (014A), 5B (014B), or both comprise(s) a total length, extending from the nasal base, e.g., an upper excision boundary (002) along the nasal base, to the upper vermillion border (020). In aspects, the total length is represented by the combination of an excision height segment and a final lip height segment. In aspects, a first portion of radial marking(s) 5A (014A), 5B (014B), or both comprise(s) an excision height segment bound by the upper excision boundary marker (002) and the lower excision boundarymarker (004). In aspects, the excision height segment identifies the portion of the upper lip along radial marking 5 A (014 A) or radial marking 5B (014B) to be excised during the procedure to which the marking system is applied, e.g., an upper lip lift procedure. In aspects, a second portion of radial marking(s) 5A (014A), 5B (014B), or both comprise(s) a final lip height segment bound by the lower excision boundary marker (004) and the upper vermillion border (020). In aspects, the final lip height segment identifies the portion of the upper lip along radial marking(s) 5A (014A), 5B (014B), or both which will remain post-excision.

[0440] According to certain aspects, at least a portion, part, or point of / along radial marking(s) 5A (014A), 5B (014B), or both, guide the performance of one or more steps of an upper lip lift procedure. In aspects, as is described elsewhere herein, a least a portion, part, or point of radial marking(s) 5A (014A), 5B (014B), or both guide the performance of one or more ancillary or concomitantly performed aesthetic modification procedure (e.g., performed in addition to an upper lip lift procedure, e.g., subnasal upper lip lift procedure), such as, e.g., a corner lip lift procedure.Radial Markings 5A / 5B: Total Length

[0441] In aspects, radial marking 5A (014A), radial marking 5B (014B), or both can have any total length (“5A-T” and “5B-T”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0442] In aspects, radial marking 5A (014A) has a total length (“5A-T”) of between about 10 mm and about 26 mm, such as, e.g., -10 mm - ~25 mm, ~10 mm - ~24 mm, ~10 mm - ~23 mm, ~10 mm - -22 mm, ~10 mm - ~21 mm, ~10 mm - ~20 mm, ~10 mm - -19 mm, ~10 mm - ~18 mm, ~10 mm - -17 mm, ~10 mm - ~16 mm, ~10 mm - -15 mm, ~10 mm - -14 mm, ~10 mm - -13 mm, or, e.g., ~10 mm - -12 mm.

[0443] In aspects, radial marking 5A (014A) has a total length of, e.g., -11 mm - -26 mm, -12 mm - -26 mm, -13 mm - -26 mm, -14 mm - -26 mm, -15 mm - -26 mm, -16 mm - -26 mm, -17 mm - -26 mm, -18 mm - -26 mm, -19 mm - -26 mm, or -20 mm - -26 mm.

[0444] In aspects, radial marking 5A (014A) has a total length of -11 mm - -25 mm, -12 mm - -24 mm, -13 mm - -22 mm, -14 mm - -21 mm, -15 mm - -20 mm, or, e.g., -15 mm - -19 mm, such as, e.g., -12 mm, -13 mm, -14 mm, -15 mm, -16 mm, -17 mm, -18 mm, or, e.g., -19 mm or -20 mm.

[0445] In aspects, radial marking 5B (014B) has a total length (“5B-T”) of between about 10 mm and about 26 mm, such as, e.g., -10 mm - -25 mm, -10 mm - -24 mm, -10 mm - -23 mm, -10 mm - -22 mm, -10 mm - -21 mm, -10 mm - -20 mm, -10 mm - -19 mm, -10 mm -~18 mm, -10 mm - -17 mm, -10 mm - ~16 mm, -10 mm - -15 mm, ~10 mm - -14 mm, -10 mm - -13 mm, or, e.g., ~10 mm - ~12 mm.

[0446] In aspects, radial marking 5B (014B) has a total length of, e.g., -1 1 mm - ~26 mm, ~12 mm - ~26 mm, -13 mm - ~26 mm, -14 mm - ~26 mm, -15 mm - ~26 mm, ~16 mm - ~26 mm, -17 mm - ~26 mm, -18 mm - ~26 mm, -19 mm - ~26 mm, or ~20 mm - ~26 mm.

[0447] In aspects, radial marking 5B (014B) has a total length of -11 mm - ~25 mm, ~12 mm - ~24 mm, -13 mm - -22 mm, -14 mm - ~2I mm, -15 mm - ~20 mm, or, e.g., -15 mm - -19 mm, such as, e.g., ~12 mm, -13 mm, ~14 mm, -15 mm, ~16 mm, -17 mm, ~18 mm, or, e.g., -19 mm or -20 mm.Radial Markings 5A / 5B: Excision Height Segment Length

[0448] In aspects, radial marking 5A (014A), radial marking 5B (014B), or both can have any excision height segment length (“5A-EX” and “5B-EX”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0449] In aspects, radial marking 5A (014A) comprises an excision height segment length (“5A-EX”) of about 0 mm to about 10 mm, such as, e.g., -0 mm - -9 mm, -0 mm - -8 mm, -0 mm - -7 mm, -0 mm - -6 mm, -0 mm - -5 mm, -0 mm - -4 mm, -0 mm - -3 mm, or -0 mm - -2 mm.

[0450] In aspects, radial marking 5A (014A) comprises an excision height segment length of about 1 mm - -10 mm, 2 mm - -10 mm, 3 mm - -10 mm, 4 mm - -10 mm, 5 mm - -10 mm, 6 mm - -10 mm, 7 mm - -10 mm, 8 mm - -10 mm, or 9 mm - -10 mm.

[0451] In aspects, radial marking 5A (014A) comprises an excision height segment length of about 0 mm - -8 mm, -0 mm - -6 mm, -1 mm - -8 mm, -1 mm - -6 mm, -1 mm - -5 mm, -1 mm - -4 mm, -2 mm - -6 mm, -2 mm - -5 mm, -2 mm - -4 mm, or -1 mm - -2 mm.

[0452] In aspects, radial marking 5B (014B) comprises an excision height segment length (“5B-EX”) of about 0 mm to about 10 mm, such as, e.g., -0 mm - -9 mm, -0 mm - -8 mm, -0 mm - -7 mm, -0 mm - -6 mm, -0 mm - -5 mm, -0 mm - -4 mm, -0 mm - -3 mm, or -0 mm - -2 mm.

[0453] In aspects, radial marking 5B (014B) comprises an excision height segment length of about 1 mm - -10 mm, 2 mm - -10 mm, 3 mm - -10 mm, 4 mm - -10 mm, 5 mm - -10 mm, 6 mm - -10 mm, 7 mm - -10 mm, 8 mm - -10 mm, or 9 mm - -10 mm.

[0454] In aspects, radial marking 5B (014B) comprises an excision height segment length of about 0 mm - -8 mm, -0 mm - -6 mm, -1 mm - -8 mm, -1 mm - -6 mm, -1 mm - -5 mm, -1 mm - -4 mm, -2 mm - -6 mm, -2 mm - -5 mm, -2 mm - -4 mm, or -1 mm - -2 mm.Radial Markings 5A / 5B: Final Lip Height Segment Length

[0455] In aspects, radial marking 5 A (014A), radial marking 5B (014B), or both can have any final lip height length (“5A-FH” and “5B-FH”, respectively) suitable and effective for achieving targeted aesthetic effect(s).

[0456] In aspects, radial marking 5A (014A) comprises a final lip height segment length (“5A-FH”) of between about 1 mm - -22 mm, such as, e.g., -1 mm - ~21 mm, -1 mm - ~20 mm, -1 mm - -19 mm, -1 mm - ~18 mm, -1 mm - -17 mm, -1 mm - ~16 mm, ~1 mm - -15 mm, -1 mm - ~14 mm, -1 mm - -13 mm, -1 mm - ~12 mm, -1 mm - ~11 mm, -1 mm - 10 mm, -1 mm - -9 mm, or, e.g., -1 mm - ~8 mm.

[0457] In aspects, radial marking 5A (014A) comprises a final lip height segment length of -2 mm - -22 mm, -3 mm - -22 mm, -4 mm - -22 mm, -5 mm - -22 mm, -6 mm - -22 mm, -7 mm - -22 mm, -8 mm - -22 mm, -9 mm - -22 mm, -10 mm - -22 mm, -1 1 mm - -22 mm, -12 mm - -22 mm, -13 mm - -22 mm, -14 mm - -22 mm, -15 mm - -22 mm, or, e.g., -16 mm- -22 mm.

[0458] In aspects, radial marking 5A (014A) comprises a final lip height segment of -2 mm - -21 mm, -3 mm - -20 mm, -4 mm - -19 mm, -5 mm - -18 mm, -6 mm - -17 mm, -7 mm - -16 mm, or -8 mm - -15 mm, e.g., -12 mm - -20 mm, -12 mm - -19 mm, or, e.g., -13 mm - -19, e.g., -16 mm - -18 mm.

[0459] hi aspects, radial marking 5B (014B) comprises a final lip height segment length (“5B-FH”) of between about 1 mm - -22 mm, such as, e.g., -1 mm - -21 mm, -1 mm - -20 mm, -1 mm - -19 mm, -1 mm - -18 mm, -1 mm - -17 mm, -1 mm - -16 mm, -1 mm - -15 mm, -1 mm - -14 mm, -1 mm - -13 mm, -1 mm - -12 mm, -1 mm - -11 mm, -1 mm - -10 mm, -1 mm - -9 mm, or, e.g., -1 mm - -8 mm.

[0460] In aspects, radial marking 5B (014B) comprises a final lip height segment length of -2 mm - -22 mm, -3 mm - -22 mm, -4 mm - -22 mm, -5 mm - -22 mm, -6 mm - -22 mm, -7 mm - -22 mm, -8 mm - -22 mm, -9 mm - -22 mm, -10 mm - -22 mm, -1 1 mm - -22 mm, -12 mm - -22 mm, -13 mm - -22 mm, -14 mm - -22 mm, -15 mm - -22 mm, or, e.g., -16 mm- -22 mm.

[0461] In aspects, radial marking 5B (014B) comprises a final lip height segment of -2 mm - -21 mm, -3 mm - -20 mm, -4 mm - -19 mm, -5 mm - -18 mm, -6 mm - -17 mm, -7 mm - -16 mm, or -8 mm - -15 mm, e.g., -12 mm - -20 mm, -12 mm - -19 mm, or, e.g., -13 mm - -19, e.g., -16 mm - -18 mm.

[0462] In aspects, the excision height segment length of radial marking 5A (014A), radial marking 5B (014B), or both radial markings 5A (014A) and 5B (014B) is / are between about 8% and about 20% of the length of final lip height segment of the same radial marking, such as, e.g., -8% - -18%, -8% - -16%, -8% - -14%, -8% - -12%, or -8% - -10% of the final lip height segment length of the same radial marking, as in, e.g., -10% - -20%, -12% - -20%, -14% - -20%, -16% - -20% or -18% - -20% of the final lip height segment length, for example -9% - -19%, -10% - -18%, -1 1% - -17%, -12% - -16%, or, e.g., -13% - -15% of the final lip height segment length of the same radial marking.Intermediary Marking(s)

[0463] In aspects, marking system(s) provided herein comprise one or more additional markings, referred to herein as “intermediary marking(s).” In aspects, a primary radial marking is one or more of radial markings 1, 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), 4B (012B), 5A (014A), and 5B (014B) (“p-radial marking(s)”), as described elsewhere herein, and an intermediary marking is an intermediary radial marking (“i-radial marking”) positioned in between two neighboring primary radial markings, e.g. in between radial markings 1 and 2A (008A); in between radial markings 1 and 2B (008B); in between radial markings 2A (008A) and 3A (010A); in between radial markings 2B (008B) and 3B (010B); in between radial markings 3A (010A) and 4A (012A); in between radial markings 3B (010B) and 4B (012B); in between radial markings 4A (012A) and 5A (014A); or in between radial markings 4B (012B) and 5B (014B). In aspects, i-radial marking(s) further divides the space between two p-radial markings as described above. In aspects, an i-radial marking present between two neighboring p-radial markings detectably or significantly increase(s) the level of control that the marking system(s) provides to a practitioner for attaining targeted aesthetic design feature(s) resulting from the aesthetic modification procedure(s), e.g., upper lip lift procedure(s), e.g., deep plane release upper lip lift procedure(s) comprising the application or use of marking system(s) provided herein.

[0464] In certain aspects, the space between radial markings 1 and 2A (008A), 1 and 2B (008B), 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), 4A (012A) and 5A (014A), 4B (012B) and 5B (014B), or any two or more thereof is / are divided in half with an additional radial marking line (an i-radial marker). In aspects, the space between radial markings 1 and 2A (008A), 1 and 2B (008B), 2A (008A) and 3A (010A), 2B (008B) and 3B (010B), 3A (010A) and 4A (012A), 3B (010B) and 4B (012B), 4A (012A) and 5A (014A), 4B (012B) and 5B (0146), or any two or more thereof is / are dividedin half with an additional radial marking line (an i-radial marker) and the target slope of the upper vermillion border (020) established by the marking system comprises an about 1 mm to an about 2 mm, e.g., an about 1.5 mm or, e.g., an about 1 mm, height difference between the point(s) of any new i-radial marking line along the upper vermillion border (020) and any immediately neighboring one or two points along the upper vermillion border (020) associated with p-radial markings 2A (008A), 3A (010A), 4A (012A), 5A (014A), 2B (008B), 3B (010B), 4B (012B), or 5B (014B).

[0465] In certain aspects a single i-radial marking is present (e.g., an i-radial marking on one lateral side of radial marker 1 (006) such that the i-radial marker is not present as an A-B pair (A-B pairs being described elsewhere herein.) In aspects, an i-radial marker is present as an A-B pair, with one marker of the A-B pair of i-radial markers being positioned on one lateral side of radial marker 1 (006) and another marker of the A-B pair of i-radial markers being position on another lateral side of radial marker 1 (006).

[0466] According to certain aspects, i-radial marking(s) are detectably or significantly non-vertical or comprise at least one portion which is detectably or significantly non- vertical. In aspects, i-radial marking(s) comprise at least a portion of their length which is at least generally, is at least substantially, is at least essentially, is essentially, or is vertical. In aspects, i-radial marking(s) comprise at least a portion of their length which is at least generally, is at least substantially, is at least essentially, is essentially, or is vertical while also comprising a portion of their length which is detectably or significantly non-vertical. In aspects, i-radial marker(s) is / are positioned lateral to one or more of radial markings 1, 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), or 4B (012B), and the i-radial marker, or at least a portion thereof, may detectably or significantly rotate laterally toward the angle of the nasolabial fold(s) (016A) and (016B), respectively. In aspects, the lateral rotation of an i-radial marker(s) is detectably or significantly greater than that of one or more of radial marker 1 (006), radial marker 2A (008A), radial marker 2B (008B), radial marker 3A (010A), radial marker 3B (010B), radial marker 4A (012A), and radial marker 4B (012B). In aspects a portion of the upper lip height segment of an i-radial marker is at least generally, is at least substantially, is at least essentially, is essentially, or is vertical. In aspects, a portion of an i-radial segment spanning a portion of the upper lip to be excised (excised height segment) is detectably or significantly non-vertical.

[0467] In certain aspects, i-radial marking(s) comprise(s) a total length, extending from the nasal base, e.g., an upper excision boundary marker (002) following the nasal base, to the upper vermillion border (020). In aspects, the total length is represented by the combination of anexcision height segment and a final lip height segment. In aspects, a first portion of i-radial marking(s) comprise(s) an excision height segment bound by the upper excision boundary marker (002) and the lower excision boundary marker (004). In aspects, the excision height segment identifies the portion of the upper lip along the i-radial marking(s) to be excised during the procedure to which the marking system is applied, e.g., an upper lip lift procedure. In aspects, a second portion of i-radial marking(s) comprise(s) a final lip height segment bound by the lower excision boundary marker (004) and the upper vermillion border (020). In aspects, the final lip height segment identifies the portion of the upper lip along the i-radial marking(s) which will remain post-excision.

[0468] In aspects, i-radial marking(s) can have any total length (“iRM -T”) suitable and effective for achieving targeted aesthetic effect(s). In aspects, a total length can be any total length presented for any one or more p-radial marker(s) provided herein or falling within range(s) of total length(s) of p-radial marker(s) presented herein.

[0469] In aspects, i-radial marking(s) can have any excision height segment length (“iRM -EX”) suitable and effective for achieving targeted aesthetic effect(s). In aspects, an excision height segment length can be any excision height segment length presented for any one or more p-radial marker(s) provided herein or falling within range(s) of excision height segment length(s) of p-radial marker(s) presented herein.

[0470] hi aspects, i-radial marking(s) can have any final upper lip height length (“iRM - FH”) suitable and effective for achieving targeted aesthetic effect(s). In aspects, a final upper lip height length can be any final upper lip height length presented for any one or more p-radial marker(s) provided herein or falling within range(s) of final upper lip height length(s) of p-radial marker(s) presented herein.

[0471] In certain aspects, i-radial marking(s) can have a total length which falls between the total length(s) of each neighboring p-radial marking(s). In certain aspects, i-radial marking(s) can have an excision height segment length which falls between the excision height segment length(s) of each neighboring p-radial marking(s). In certain aspects, i-radial marking(s) can have a final upper lip height length which falls between the final upper height length(s) of each neighboring p-radial marking(s).Subnasal Lip / Subfacial Lip & Lateral Mouth Demarcation

[0472] In aspects, marking system(s) provided herein comprise at least one, such as, e.g., at least 2, marking(s) / marker(s) which delineate at least a first defined region of the upper lip from at least a second defined region of the upper lip.

[0473] In aspects, marking system(s) provided herein comprise at least one, such as, e.g., at least 2, marking(s) / marker(s) which mark a boundary of a first defined region of the upper lip identifiable as the “subnasal lip.” In aspects, marking system(s) provided herein comprise at least one, such as, e.g., at least 2, marking(s) / marker(s) which mark a boundary of a second defined region of the upper lip identifiable as the “subfacial lip and lateral mouth.” In aspects, marking system(s) provided herein comprise at least one, such as, e.g., at least 2, marking(s) / marker(s) which mark a boundary between a first defined region of the upper lip identifiable as the subnasal lip and a second defined region of the upper lip identifiable as the subfacial lip and lateral mouth. In aspects, the marker(s) delineate the change in physical characteristic(s) of the upper lip which characterize the two regions, e.g., the subnasal lip and the subfacial lip and lateral mouth. In aspects, marking system(s) provided herein comprise 2 marker(s) which delineate the two regions, wherein the first marker is positioned lateral to the mouth on one side, the second marker is positioned lateral to the mouth on the opposing side. In aspects, marking system(s) provided herein comprise 2 marker(s) which delineate the two regions, wherein the first marker is positioned lateral to the mouth on one side, the second marker is positioned lateral to the mouth on the opposing side, and the region in between the two markers is identified as the subnasal lip. In aspects, marking system(s) provided herein comprise 2 marker(s) which delineate the two regions, wherein the first marker is positioned lateral to the mouth on one side, the second marker is positioned lateral to the mouth on the opposing side, and the region(s) lateral to each marker on both sides of the mouth is / are identified as the subfacial lip and lateral mouth.

[0474] In aspects, the at least first and second defined regions described above, e.g., the subnasal lip and the subfacial lip and lateral mouth of the upper lip, indicated by marking system(s) delectably or significantly physically differ from one another in one or more structurally identifiable ways. In aspects, the at least first and second defined regions described above, e.g., the subnasal lip and the subfacial lip and lateral mouth of the upper lip, indicated by marking system(s) detectably or significantly physically differ from one another in one or more structurally identifiable ways which result in each of the regions differing from the other in their sensitivity to the effect(s) of aesthetic modification procedure(s), e.g., their sensitivity to the lift effect of upper lip lift procedure(s).

[0475] In certain aspects, a first defined region of the upper lip indicated or demarcated by the marking system, e.g., a region identified as the subnasal lip, is more densely attached to the pyriform than the at least second defined region of the upper lip indicated or demarcated bythe marking system, e.g., a region identified as the subfacial lip and lateral mouth. In aspects, the first defined region, e.g., subnasal lip, is supported by the front teeth.

[0476] In aspects, a second defined region of the upper lip indicated or demarcated by the marking system, e.g., a region identified as the subfacial lip and lateral mouth, hangs from the anterior cheek and face.

[0477] According to certain aspects, marking system(s) provided herein comprise at least one, such as, e.g., at least 2, marking(s) / marker(s) which mark the boundary between first and second defined regions of the upper lip, e.g., the subnasal lip and the subfacial lip and lateral mouth. In aspects, marking system(s) provide 2 such markers. In aspects, the markers are bilateral radial markings 4A (012A) and 4B (012B), wherein each of markings 4A (012A) and 4B (012B) respectively mark the border of the first region of the upper lip identified as the subnasal lip as it transitions to the second region of the upper lip identified as the subfacial lip and lateral mouth. In aspects, the subnasal lip region and the subfacial lip and lateral mouth regions are demarcated by the 2 bilateral radial markings 4A (012A) and 4B (012B), the subnasal lip region being located between radial markings 4A (012 A) and 4B (012B) and the subfacial lip and lateral mouth regions being located lateral to each of 4A (012A) and 4B (012B), respectively.

[0478] In aspects, as stated above, differ from one another in their sensitivity to the effects of one or more element(s) of an aesthetic modification procedure, such as, e.g., the lift effect(s) of an upper lip lift procedure. In aspects, the marking(s), e.g., radial markings 4A (012A) and 4B (012B), identify and therefore determine the lateral extent of the lift effect on the upper lip caused by the upper lip lift. That is, in aspects, an amount of lift performed within a first defined region, e.g., subnasal lip, may yield a greater degree of lift than the same amount of lift performed within a second defined region. Such a difference, in aspects, results from the structural difference(s) between the two regions.

[0479] In certain aspects, the demarcation of the two defined regions described in this section is relevant to both a primary aesthetic modification procedure, e.g., an upper lip lift, and one or more ancillary or concomitant procedure(s), such as a corner lip lift procedure. In aspects, two markers, e.g., bilateral radial markings 4A (012A) and 4B (012B), demarcate a region (e.g., subnasal lip) lateral to which the corner lift procedure is initiated (as applicable to the side(s) of the subject’s mouth undergoing the corner lip procedure). In aspects, two markers, e.g., bilateral radial markings 4A (012A) and 4B (012B), demarcate a region (e.g., subnasal lip) medial to which the comer lift procedure is initiated (as applicable to the side(s) of the subject’s mouthundergoing the corner lip procedure) to shorten the final lip height (segment of each marking between the second lower incision point / lower excision boundary along the lower excision boundary marker (004) and a third point located along the upper vermillion border (020)) of radial marking(s) 4A (012A) and 4B (012B) (as applicable to the side(s) of the subject’s mouth undergoing the corner lip procedure).Type I & Type II Marking(s)

[0480] In aspects, marking system(s) provided by the disclosure further comprise at least one marking not characterizable as a radial marking or an excision boundary marker. In aspects, marking system(s) provided by the disclosure comprise one or more marking(s) suitable for use in an aesthetic modification procedure, such as an upper lip lift procedure, or a procedure performed separately from or concomitant to, an upper lip lift procedure. In aspects, marking system(s) provided by the disclosure comprise marking(s) suitable for use in an ancillary procedure. In aspects, marking system(s) provided by the disclosure comprise marking(s) suitable for use in an ancillary procedure performed concomitant to an upper lip lift procedure, such as, e.g., a deep plane release upper lip lift, wherein the ancillary procedure is one or more of a comer lift, a nasal base suspension, a muscle suspension, or a combination of any or all thereof.

[0481] In aspects, marking system(s) provided by the disclosure comprise one or more marking(s) for facilitating a comer lip lift procedure. In aspects, a comer lip lift procedure marking comprises an at least substantially elliptical or fusiform shape. In aspects, a comer lip lift procedure marking ends laterally at the oral commissure. In aspects, a comer lip lift procedure marking comprises an at least substantially elliptical or fusiform shape and ends laterally at the oral commissure, referred to herein as a “Type I” marking ((042A) or (042B)). In aspects, a Type I marking ((042A) or (042B)) is a guide in a corner lip lift procedure directed to the exposure and lifting of the lateral vermillion. In aspects, a Type I marking ((042 A) or (042B)) is a guide in a corner lip lift procedure (e.g., a deep plane corner lip lift procedure) directed to revealing an increased amount of lateral vermillion.

[0482] In aspects, marking system(s) provided by the disclosure comprise a corner lip lift procedure marking comprising an enclosed shape. In aspects, a comer lip lift procedure marking extends past the commissure. In aspects, a corner lip lift procedure marking comprises a detectably or significantly upward inflection. In certain aspects, a comer lip lift procedure marking comprises an enclosed shape which extends past the commissure and comprises a detectably or significantly upward inflection, referred to herein as a “Type II” marking ((044A) or (044B)). In aspects, a Type II marking ((044A) or (044B)) is a guide in a corner lip liftprocedure (e.g., a deep plane corner lip lift procedure) directed to lengthening the vermillion, treating angular depression around the mouth, lifting the commissure, or neutralizing downpointing rhytids extending inferior to the chelion, or, in aspects, the procedure is directed to combination(s) of lengthening the vermillion, treating angular depression around the mouth, lifting the commissure, and neutralizing down-pointing rhytids extending inferior to the chelion.

[0483] Figure 5 herein provides an exemplary embodiment of a Type I marking. As provided, a Type I marking is shown on both sides of the mouth (labeled (042A) and (042B), respectively). Figure 6 herein provides an exemplary embodiment of a Type II marking. As provided, a Type II marking is shown on both sides of the mouth (labeled (044A) and (044B), respectively). The diagonal lines in each of Figures 5 and 6 mark the transition from the subnasal to the subfacial lip, described elsewhere herein, wherein the subfacial lip lacks significant support and accordingly is where the vermillion role tapers off (described as radial markers (012A) and (012B), respectively, elsewhere herein). In Figure 5, a Type I marker (042A) or (042B) is provided utilizing an elliptical excision to replace philtral skin with red vermillion. In Figure 6, a Type II marker (044A) or (044B) is provided wherein there is an inflection past the commissure which effects a change to the lower lateral lip angulation and insertion, and the Type II marker (044A) or (044B) is used to guide the lengthening and appearance of the upper lip. Figure 6 further illustrates the horizontal markers H-A (046A) and H-B (046B), such markers being elements of Type II markers, and which are described elsewhere herein.

[0484] In certain aspects, marking systems do not comprise a Type I marker ((042A) or (042B)), a Type II marker ((044A) or (044B)), or lack both a Type I marker ((042A) or (042B)) and a Type II marker ((044A) or (044B)).Horizontal Reference Point Markings

[0485] In some aspects, marking system(s) provided herein comprise one or more marker(s) indicating a reference point for use in performing a procedure ancillary to an upper lip lift procedure, such as, e.g., a concomitantly performed comer lip lift procedure. In aspects, marking system(s) comprise one or more marker(s) indicating a reference point for use in performing a corner lift incision, wherein the position of the indicator is established based on the positioning of one or more radial marking(s). In aspects, the position of such indicator(s) is / are established based upon the position of point(s) along the upper vermillion border (020) of two or more radial marking(s). In aspects, the position of such indicators is based upon the point(s) onthe upper vermillion border (020) of radial marking line(s) 4A (012A), 4B (012B), or both, as applicable to the side(s) of the subject’s mouth undergoing the comer lip procedure.

[0486] In aspects, the point(s) on the upper vermillion border (020) of radial marking lines 4A (012A), 4B (012B), or both, as applicable to the side(s) of the subject’s mouth undergoing the corner lip procedure, is / are used as a starting point for an at least generally, at least substantially, at least essentially, essentially, or completely horizontal marking line, e.g., an at least generally straight, at least substantially straight, at least essentially straight, essentially straight, or straight horizontal marking line drawn laterally from such point(s). In aspects, the marking(s) establish a reference point, e.g., an upper reference point, e.g., indicating the “upper limb” of a corner lip incision, for use in performing a comer lift incision. These marking(s) are referred to herein as “horizontal marking A” (“H-A”) (046A) and “horizontal marking B” (“H- B”) (046B), respectively. In aspects, such marking(s) are a component of a Type II marking (044A) or (044B), respectively, described above. In aspects, additional radial marking(s) can assist in the performance of a comer lip lift procedure. In aspects, radial marker(s) 5 A (014A), 5B (014B), or both, can be used to determine the height of an excision for which a Type II marker (044A) or (044B) is a guide (e.g., a Type II lift) by maintaining the final lip height segment length of radial markers 5A (014A), 5B (014B), or both at least generally the same, at least substantially the same, at least essentially the same, essentially the same, or the same as the final lip height segment(s) of radial markers 4A (012A), 4B (012B), or both. In certain aspects, where marking H-A (046A), marking H-B (046B), or both indicate the upper limb of a corner lift incision, the lower limb follows the red / white border of the vermillion. In aspects, horizontal marking(s) H-A (046A), H-B (046B), or both end before reaching the nasolabial fold line(s) (016A) and (016B), respectively, of the relaxed skin tension line globe. H-A (046A) and H-B (046B) are labeled in Figure 6 provided herein.Extension Markings

[0487] In aspects, marking system(s) provided herein comprise one or more marker(s) indicating a reference point(s) for use in performing procedure(s) ancillary to an upper lip lift procedure, such as, e.g., a concomitantly performed comer lip lift procedure. In aspects, marking system(s) comprise one or more marker(s) indicating a reference point for use in performing a corner lift incision, wherein the position of the indicator is established based on the positioning of one or more radial marking(s). In aspects, marking system(s) comprise one or more marker(s) indicating reference point(s) for use in performing a comer lift procedure, wherein the marker(s) is / are (an) at least generally horizontal, at least substantially horizontal, at least essentiallyhorizontal, essentially horizontal, or horizontal lateral line extension(s) beginning at the point where radial marker(s) 4A (012A), 4B (012B), or both, respectively, intersect with the lower excision boundary marker (004) (at a lower incision point marker of radial marker(s) 4A (012A), 4B (012B), or both, respectively) and are directed laterally therefrom. In aspects such markers are referred to herein as “lateral extension marker A” (“LE-A”) (018 A) and “lateral extension marker B” (“LE-B”) (018B). Figures 2H and 3A (010A) illustrate exemplary embodiment(s) of marker(s) LE-A (018A) and LE-B (018B). See, e.g., Figure 2H wherein LE-A (018A) and LE-B (018B) are identified. See also, e.g., Figure(s) 3A and 3B.

[0488] Marking System and Lip Shape, Slope

[0489] In aspects, length(s) of the segment(s) of each of one or more radial marking(s) representing the final height of the upper lip at each respective radial marking, the length of segment(s) of each of one or more radial marking(s) representing the excision height at each respective radial marking, or a combination thereof, establish(es) the lip shape resulting from a an upper lip lift procedure (e.g., with or without concomitant comer lip lift(s)) comprising the application of the marking system(s) comprising such radial marking(s) provided herein. In aspects, the disclosure provides marking system(s) for guiding aesthetic modification procedure(s) wherein the marking system is established according to target aesthetic effect(s) resulting from the procedure(s) and wherein the application and incorporation of the marking system(s) in the procedure(s) predictably yield(s) the target aesthetic effect(s).

[0490] Herein, use of the word “predictably”, for example as used in the phrase above, “. . .wherein the application and incorporation of the marking system(s) in the procedure(s) predictably yield(s) the target aesthetic effect(s),” should be interpreted to mean that procedure(s) yield the target effect(s) which marking system(s) is / are each designed to achieve at least about 50%, >~55%, >~60%, >~65%, >~70%, >~75%, >~80%, >~85 %, >~90%, >~95%, or, -100% of the time. In aspects, “predictably” as used here means that, e.g., about 55 out of every 100 (55 / 100) procedures comprising use of the marking system(s), e.g., about 55 / 100, -60 / 100, -65 / 100, -70 / 100, -75 / 100, -80 / 100, -85 / 100, -90 / 100, -95 / 100, or, e.g., 100 / 100 procedures comprising use of the marking system(s) achieve the target aesthetic effect(s) which the marking system(s) are designed to achieve without requiring a secondary procedure to amend results, e.g., without requiring revision.

[0491] In aspects, a target aesthetic shape of the upper lip, one or more curves of the upper vermillion, or both, establish or otherwise define, by the positioning of the lower excisionboundary marker (004), a distance between the lower excision boundary marker (004) and the point located on the upper vermillion border (020) along of the radial marker(s), e.g., each of the at least 7 radial markings. In aspects, the distance between the lower excision boundary marker (004) and the upper vermillion border (020), e.g., the established distance between second and third points along each of the radial marking(s) (e.g., each of the at least 7 radial marking(s)) define a final lip height of the upper lip along each of the marking(s).

[0492] According to certain aspects, a final upper lip height indicated by any one or more of the radial marking(s) is at least about 8 mm, such as, e.g., >~9 mm, >~10 mm, >~11 mm, >~12 mm, >~13 mm, >~14 mm, >~15 mm, or >~16 mm. In aspects, a final upper lip height indicated by any one or more of the radial marking(s) is at least about 11 mm. Figure 4 provided herein exemplifies measurements of the final lip height segment of each of radial markings 1 and radial markings 2, 3, 4, and 5 belonging to a single group (e.g., on one side of radial marking 1 (006) such that they are identifiable as a group of markers; e.g., Group A markers or Group B markers (such as radial marking(s) 2B (008B), 3B (010B), 4B (012B), and 5B (014B).) Therein, exemplified final upper lip heights are, e.g., length A for radial marker 1 (006), e.g., about 12 mm, length B for radial marker 2 (e.g., 2B (008B)), also, e.g., about 12 mm, length C for radial marker 3 (e.g., 3B (010B)), e.g., about 14 mm, length D for radial marker 4 (e.g., 4B (012B)), e.g., about 16 mm, and length E for radial marker 5 (e.g., 5B (014B)), e.g., about 17 mm.

[0493] hi certain aspects, final lip height indicated by any two or more of the radial marking(s), e.g., the segment(s) of two or more radial marker(s) representing final lip height, can vary across radial markers by between about 0% and about 70%, such as, e.g., by -0% - -65%, -0% - -60%, -0% - -55%, -0% - -50%, -0% - -45%, -0% - -40%, -0% - -35%, -0% - -30%, -0% - -25%, -0% - -20%, -0% - -15%, -0% - -10%, or -0% - -5%.

[0494] In certain aspects, final lip height indicated by any two or more of the radial marking(s), e.g., the segment(s) of two or more radial marker(s) representing final lip height, can vary across radial markers by between about 5% and about 70%, such as, e.g., -10% - -70%, -15% - -70%, -20% - -70%, -25% - -70%, -30% - -70%, -35% - -70%, -40% - -70%, -45% - -70%, -50% - -70%, -55% - -70%, -60% - -70%, or -65% - -70%.

[0495] In certain aspects, final lip height indicated by any two or more radial marking(s), e.g., the segment(s) of two or more radial marker(s) representing final lip height can vary across radial markers by about 0%, by -5%, by -10%, by -15%, by -20%, by -25%, by -30%, by -35%, by -40%, by -45%, by -50%, by -55%, by -60%, by -65%, or, e.g., by -70% or more. In aspects, marking system(s) comprise two or more radial marking(s) each having a segmentrepresenting the final lip height wherein the longest final lip height segment of the markings is no more than about 0%, 5%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, or 70% longer than the shortest lip final lip height segment of the markings.

[0496] In aspects, final upper lip height segment(s) is / are established, by the positioning of one or more marker(s) of marking system(s), to attain one or more target aesthetic effects, such as, e.g., overall facial balance, incisor display, final lip height, etc. In aspects, the final lip height segment of radial marking(s) for one or more radial marking(s) is established while the lip is in repose and is not delectably or significantly stretched. In aspects, the final lip height segment in / of radial marking(s) 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), 4B (012B), or combination(s) thereof is / are placed while the lip is in repose and is not held under detectable or significant tension. In aspects, the final lip height segment of radial marking(s), 2A (008A), 2B (008B), 3A (010A), 3B (010B), 4A (012A), 4B (012B), or combination(s) thereof is / are established while the lip is in repose and not detectably or significantly stretched while the final height segment of radial marking 1 (006) is established while the lip is held under gentle tension.

[0497] According to certain aspects, target aesthetic result(s) include a target shape of the upper vermillion. According to certain aspects, target aesthetic result(s) include a target slope of the upper vermillion border. In aspects, length(s) of segments(s) of one or more radial marking(s) representing the final height of the upper lip, the length(s) of segment(s) representing excision height, or a combination thereof establishes the slope of the upper vermillion (herein, “upper vermillion,” unless otherwise indicated or contradicted, typically can be read as “upper vermillion border,” and vice-versa) resulting from the aesthetic modification procedure(s) / method(s) incorporating the use of radial markings(s), such as method(s) of performing subnasal upper lip lift(s), e.g., deep plane release upper lip lift procedure(s) (e.g., with or without concomitant corner lip lift(s)). In aspects, marking system(s) and associated mathematical calculation(s) and assessment(s) disclosed herein establish target upper vermillion border slope(s) resulting from the performance of upper lip lift procedures(s) comprising use of the marking system(s) and associated mathematical calculation(s) and assessment(s).

[0498] In certain aspects, the length(s) of segment(s) of one or more radial marking(s) representing the final height of the upper lip, the length(s) of the segment(s) of one or more radial marking(s) representing the excision height, or a combination thereof, along each radial marking establish(es) the slope of the upper vermillion border (020) resulting from the application of / incorporation of the radial marking(s) in method(s) of performing subnasal lip liftprocedure(s), wherein the slope of the upper vermillion border (020) is the vertical descent of the upper vermillion border (020) from the Cupid’s peak following laterally toward the oral commissure when viewing the human subject face-on. Figure 2N shows Cupid’s peak on the left labeled as CP- A and on the right labeled as CP-B.

[0499] In aspects, a target upper vermillion border (020) slope is established by the positioning of an upper excision boundary marker (002), lower excision boundary marker (004), and radial marking(s) of marking system(s) provided herein. In aspects, a target upper vermillion border (020) slope is established by at least a single central marking (e.g., radial marking 1 (006)), 3 pairs of radial markings (e.g., radial markers 2A (008A) and 2B (008B), radial markers 3A (010A) and 3B (010B), and radial markers 4A (012A) and 4B (012B)). In aspects, a target upper vermillion border (020) slope is established by use of a marking system comprising lateral reminder marking(s) used for placement of a lateral deep suture.

[0500] According to aspects, a target vermillion slope can be any slope identified as aesthetically appropriate to the subject’s accompanying facial features. In certain aspects, a target vermillion slope is characterized as a height difference along the upper vermillion border (020) between points associated with adjacent radial marker(s) of between about 1 mm and about 5 mm, e.g., ~1 mm - ~4 mm, ~1 mm - ~3 mm, or ~1 mm - ~4 mm, such as ~2 mm - ~5 mm, ~3 mm - ~5 mm, or ~4 mm - ~5 mm, as in, for example, ~2 mm - ~4 mm, or, e.g., ~2 mm. That is, in aspects, a target vermillion slope is characterized as points along the upper vermillion border (020) between, e.g., radial markers 2A (008 A) and 3 A (010A); 3 A (010 A) and 4 A (012A); 2B (008B) and 3B (010B); 3B (010B) and 4B (012B); and, e.g., in aspects further 4A (012A) and 5A (014A) and between 4B (012B) and 5B (014B) having a difference in height of between about 1 mm and about 5 mm, e.g., ~1 mm - ~4 mm, ~1 mm - ~3 mm, or ~1 mm - ~4 mm, such as ~2 mm - ~5 mm, ~3 mm - ~5 mm, or ~4 mm - ~5 mm, as in, for example, ~2 mm - ~4 mm, or, e.g., ~2 mm. Figures 3A and 3B provided herein exemplifies such a slope. Specifically, in aspects, a height difference of, for example, about 1 mm to about 3 mm, e.g., about 2 mm, between the points along the upper vermillion border (020) of two neighboring radial markers within radial markers 2A (008A), 3A (010A), 4A (012A), 2B (008B), 3B (010B), and 4B (012B) provides a post-excision slope of the upper vermillion border (020). Figures 3 A and 3B, provided herein, exemplifies this concept. Figure 4 illustrates a final lip height segment of radial marker 2B (008B) of 12 mm, a final lip height segment of radial marker 3B (010B) of 14 mm, and a final lip height segment of radial marker 4B (012B) of 16 mm provides such a target 2 mm height difference and yields such an aesthetically pleasing, target vermillion slope.

[0501] See, for example, Figure 2N.

[0502] The area defined between an upper excision boundary marker (002) and lower excision boundary marker (004) establishes the area to be excised (001), e.g., a bullhorn- shaped area to be excised.

[0503] In aspects, marking system(s) provided herein support the establishment of the height to be excised at a location on one side of the central marking 1 which is different from the height to be excised at the corresponding location on the opposite side of the central marking 1. That is, corresponding location(s) of an area to be excised (001), on either side of central marking 1 , as created by marking system(s) provided herein may not comprise uniform excision height(s). More specifically, the disclosure herein provides for targeted upper vermillion slope, tooth show, or other target feature(s) described herein which is / are established by the identification of an area to be excised (001), wherein the area to be excised comprises one or more locations identified by one or more of radial marker(s) excision segment(s) 2A-EX, 3A- EX, 4A-EX, or 5A-EX, which is / are different from one or more of corresponding marker(s) excision segment(s) 2B-EX, 3B-EX, 4B-EX, or 5B-EX, respectively.

[0504] Marking system(s) provided herein support the establishment of the area to be excised (001). As described elsewhere herein, excision height segments (“-EX” segments) of radial marker(s) are established by considering the target upper vermillion slope achieved when the height difference at the upper vermillion border of adjacent radial marker(s) (points along the upper vermillion border where two adjacent radial marker(s) meet the upper vermillion border) have a height difference of between about 1 mm and about 3 mm, such as, e.g., about 2 mm.

[0505] In aspects, non-uniformity in excision height across corresponding location(s) (e.g., right and left sides of center) of an area to be excised (001) as described here provided by the system(s) and method(s) herein provides for an improvement in consistency and predictability of aesthetic outcome(s) of procedures utilizing marking system(s) described herein.

[0506] Figure 2N illustrates an area to be excised (001). Such an area to be excised is expected to result in specific slope(s) as identified therein: slope (022A) between radial marker 1 and radial marker 2A; slope (022B) between radial marker 1 and radial marker 2B; slope (0224A) between radial marker 2A and radial marker 3A; slope (0224B) between radia...

Claims

AMENDED CLAIMS received by the International Bureau on 11 January 2025 (11.01.2025)What is claimed is:

1. A method of generating predicted outcome imagery of a surgical aesthetic modification procedure comprising(1) providing a user with a computerized device comprising (a) an interface that facilitates the collection of user input and transmission of the user input to a computer component comprising a computer component processor component that performs one or more functions on the input and returns output to the user through the interface; (b) a user interface processing component that performs one or more functions locally on the computerized device; and (c) a memory component that stores data and system instructions to be carried out by the user interface processing component, the computer component processor component, or both,(2) prompting the user to provide user-identifying information through the interface and via the user interface processing component, the computer component processor component, or both, collecting the user-identifying information and storing the useridentifying information in the memory component,(3) prompting the user to provide, via the interface, the computer component with one or more image data files, each image data file corresponding to a photographic image of at least a portion of the user’s face that is the subject of a potential surgical aesthetic modification procedure,(4) subjecting each of the one or more image data files to analysis by a facial feature recognition artificial intelligence module (FFRAI) to identify and locate a plurality of mapped facial features in the photographic image and associating the facial features with the image data file,(5) through the operation of the user interface processing component, computer component processor component, or both, applying a face image morphing function, the image morphing function carried out in part by a face imaging morphing artificial intelligence model (FIMAIM) that is trained to generate morphed facial images based onAMENDED SHEET (ARTICLE 19)expected parameters of a surgical aesthetic modification procedure, wherein the face image morphing function modifies one or more of the image data files according to one or more preprogrammed instructions or one or more artificial intelligence models in a manner resulting in one or more initial morphed facial image files each expected to correspond with the outcome of performing the surgical aesthetic modification procedure according to the one or more preprogrammed instructions or the one or more artificial intelligence models,(6) the user causing the interface processing component, computer component processor component, or both, to modulate one or more parameters associated with one or more selected facial feature elements from among the mapped facial features to generate one or more secondarily morphed facial image files,(7) through the interface permitting the user to evaluate each of the initial morphed facial image files and each of the one or more of the secondarily morphed facial image files, and(8) storing information regarding the user’s evaluation in the memory component.

2. Canceled.

3. The method of claim 1, wherein the FFRAI comprises at least one facial feature recognition neural network (FFRNN) that is trained to recognize facial features.

4. Canceled.

5. The method of claim 1, wherein the FIMAIM comprises at least one facial image morphing neural network (FIMNN), and the method comprises training the FIMNN based on user evaluation, medical expert evaluation, or a combination thereof.

6. The method of claim 1 , wherein the method comprises performing a side-by-side comparison of at least two images selected from among an unmodified photographic image of the user’s face provided by the user input, an initially morphed image file image, and one or more secondarily morphed image file images.AMENDED SHEET (ARTICLE 19)7. The method of claim 1, wherein the method comprises performing a side-by-side comparison of at least two images selected from among an unmodified photographic image of the user face provided by the user input, an initially morphed image file image, and one or more secondarily morphed image file images.

8. The method of claim 7, wherein the method comprises evaluating the secondarily morphed image files by a morphing function evaluation artificial intelligence model (MFEAI), which optionally comprises one or more morphing function evaluation neural networks (MFENN(s)).

9. The method of claim 1, wherein the method comprises providing the user with the option of selecting among a plurality of surgical aesthetic modification procedures or a combination of two or more plastic surgery procedures, wherein each surgical aesthetic modification procedure among the plurality of surgical aesthetic modification procedures corresponds to a surgical aesthetic modification procedure performed within a discrete portion of the face, and the method optionally comprises subjecting the image input provided by the user to a plurality of facial feature recognition artificial intelligence models, wherein each facial feature recognition artificial intelligence model of the plurality of facial feature recognition artificial intelligence models is trained to recognize one or more different facial features associated with a distinct part of the face.

10. The method of claim 1, wherein the method comprises providing the user with the option of selecting among a plurality of surgical aesthetic modification procedures or a combination of two or more surgical aesthetic modification procedures, wherein each surgical aesthetic modification procedure among the plurality of surgical aesthetic modification procedures corresponds to a surgical aesthetic modification procedure performed within a discrete portion of the face, and the method optionally comprises subjecting the image input provided by the user to a plurality of facial feature recognition artificial intelligence models, wherein each facial feature recognition artificial intelligence model of the plurality of facialAMENDED SHEET (ARTICLE 19)feature recognition artificial intelligence models is trained to recognize one or more different facial features associated with a distinct part of the face.

11. The method of claim 6 wherein the method comprises providing the user with the option of selecting among a plurality of surgical aesthetic modification procedures or a combination of two or more surgical aesthetic modification procedures, wherein each surgical aesthetic modification procedure among the plurality of surgical aesthetic modification procedures corresponds to a surgical aesthetic modification procedure performed within a discrete portion of the face, and the method optionally comprises subjecting the image input provided by the user to a plurality of facial feature recognition artificial intelligence models, wherein each facial feature recognition artificial intelligence model of the plurality of facial feature recognition artificial intelligence models is trained to recognize one or more different facial features associated with a distinct part of the face.

12. The method of claim 7, wherein the method comprises providing the user with the option of selecting among a plurality of surgical aesthetic modification procedures or a combination of two or more surgical aesthetic modification procedures, wherein each surgical aesthetic modification procedure among the plurality of surgical aesthetic modification procedures corresponds to a surgical aesthetic modification procedure performed in a discrete portion of the face, and the method optionally comprises subjecting the image input provided by the user to a plurality of facial feature recognition artificial intelligence models, wherein each facial feature recognition artificial intelligence model of the plurality of facial feature recognition artificial intelligence models is trained to recognize one or more different facial features associated with a distinct part of the face.

13. The method of claim 1, wherein the method comprises the user interface processing component, the computer component processor component, or both, carrying out one or more functions to evaluate whether the user’s image data file input is sufficient to perform an effective evaluation and prompting the user to provide additional or alternative image input ifAMENDED SHEET (ARTICLE 19)the one or more functions determine the image input is insufficient to provide an effective evaluation.

14. The method of claim 9, wherein the method comprises the user interface processing component, the computer component processor component, or both, carrying out one or more functions to evaluate whether the user’s image data file input is sufficient to perform an effective evaluation and prompting the user to provide additional or alternative image input if the one or more functions determine the image input is insufficient to provide an effective evaluation.

15. The method of claim 10, wherein the method comprises the user interface processing component, the computer component processor component, or both, carrying out one or more functions to evaluate whether the user’s image data file input is sufficient to perform an effective evaluation and prompting the user to provide additional or alternative image input if the one or more functions determine the image input is insufficient to provide an effective evaluation.

16. The method of claim 15, wherein the one or more functions are performed at least in part by the operation of one or more artificial intelligence models that are trained in evaluating the sufficiency of user image input.

17. The method of claim 9, wherein the method comprises prompting the user to provide one or more images for each of two or more distinct areas of the face through the interface and facilitating the association of the user image data file input with at least two different areas of the face.

18. The method of claim 10, wherein the method comprises prompting the user to provide one or more images for each of two or more distinct areas of the face through the interface and facilitating the association of the user image data file input with at least two different areas of the face.AMENDED SHEET (ARTICLE 19)19. The method of claim 11, wherein the method comprises prompting the user to provide one or more images for each of two or more distinct areas of the face through the interface and facilitating the association of the user image data file input with at least two different areas of the face.

20. The method of claim 12, wherein the method comprises prompting the user to provide one or more images for each of the two or more distinct areas of the face through the interface and facilitating the association of the user image data file input with at least two different areas of the face.

21. A method of directing a surgical aesthetic modification procedure, the method comprising(1) providing a user with a computerized device comprising (a) an interface that facilitates the collection of user input and transmission of the user input to a computer component comprising a computer component processor component that performs one or more functions on the input and returns output to the user through the interface; (b) a user interface processing component that performs one or more functions locally on the computerized device; and (c) a memory component that stores data and system instructions to be carried out by the user interface processing component, the computer component processor component or both,(2) prompting the user to provide user-identifying information through the interface and via the user interface processing component, the computer component processor component, or both collecting the user-identifying information and storing the user-identifying information in the memory component,(3) prompting the user to provide, via the interface, the computer component with one or more image data files, each image data file corresponding to a photographic image of at least a portion of the user’s face that is the subject of a potential surgical aesthetic modification procedure,AMENDED SHEET (ARTICLE 19)(4) subjecting each of the one or more image data files to an analysis by a facial feature recognition artificial intelligence module (FFRAI) to identify and locate a plurality of mapped facial features in the photographic image and associating the facial features with the image data file,(5) through the operation of the user interface processing component, computer component processor component, or both, applying a face image morphing function that modifies one or more of the image data files according to one or more preprogrammed instructions or one or more artificial intelligence models in a manner resulting in one or more initial morphed facial image files each expected to correspond with the outcome of performing the surgical aesthetic modification procedure according to the one or more preprogrammed instructions or the one or more artificial intelligence models,(6) permitting the user to cause the user interface processing component, computer component processor component, or both, to modulate one or more parameters associated with one or more selected facial feature elements from among the mapped facial features to generate one or more secondarily morphed facial image files,(7) through the interface permitting the user to evaluate the initial morphed facial image files and each of the one or more of the secondarily morphed facial image files to generate user evaluation data,(8) through the operation of the computer component processor component using the user evaluation data to generate procedure -related output that provides a medical practitioner with information that assists the medical practitioner in conducting the surgical aesthetic modification procedure,(9) the medical practitioner carrying out the surgical aesthetic modification procedure on the user based at least in part on the procedure -related output, and(10) conducting a post-surgical aesthetic modification procedure evaluation and using the post-procedure evaluation to modify one or more Al models or other functions carried out by the processor component.

22. The method of claim 21 , wherein the surgical aesthetic modification procedure- related output comprises facial image data corresponding to the user’s face and providing one orAMENDED SHEET (ARTICLE 19)more markings for guiding a plastic surgeon in applying the surgical aesthetic modification procedure.

23. The method of claim 22, wherein the surgical aesthetic modification procedure- related output comprises augmented reality output, such as a display of one or more markings for guiding a plastic surgeon in applying the surgical aesthetic modification procedure in an augmented reality output.

24. The method of claim 21 , wherein the method comprises the computer component executing one or more functions that evaluate the user evaluation and providing a system-driven evaluation of the user evaluation to the medical practitioner.

25. The method of claim 24, wherein the system-driven evaluation of the user evaluation comprises a proposed modification of the user evaluation.

26. The method of claim 25, wherein the operation of the computer component processor component facilitates a review of the user input, the system-driven evaluation, or both by the medical practitioner by relaying output and one or more prompts or one or more directions to a computer device used by the medical practitioner that is in communication with the computer component.

27. Canceled.

28. The method of claim 22, wherein the method further comprises the medical practitioner carrying out the surgical aesthetic modification procedure on the user based at least in part on the procedure -related output.

29. Canceled.AMENDED SHEET (ARTICLE 19)30. A computer system for facilitating aesthetic modification surgery patient and medical practitioner consultation comprising(1) a user interface device (UID) comprising a user interface processing component, a memory component, a data transmission component, and an interface component, wherein the UID interface component facilitates the collection of user input comprising user-identifying information and one or more image data files which are processed by the UID user interface processing component and stored in the UID memory component;(2) a computer component that in operation is in communication with the UID and comprises a computer component processor component and a computer component memory component, wherein the computer component processor component is configured to operate at least two artificial intelligence models that are specifically trained to recognize one or more facial features in different portions of a face in user image data file input, to modify facial images to reflect the likely outcome of a surgical aesthetic modification procedure, or both, and one or more artificial intelligence models that evaluates the sufficiency of user image data file input and further evaluates the efficacy of one or more system prompts, evaluates one or more system user instructions, evaluates one or more system outputs, or a combination thereof; and(3) a medical practitioner user interface device that comprises a medical practitioner interface device processor component, a medical practitioner device memory component, a medical practitioner device data transmission component, and a medical practitioner interface device interface component, wherein the medical practitioner device interface facilitates the display of one or more image data files which are processed by the computer component processor component and which comprise procedure-related output comprising information that can direct the medical practitioner in performing one or more surgical aesthetic modification procedures.

31. Canceled.

32. Canceled.AMENDED SHEET (ARTICLE 19)30033. The system of claim 30, wherein the system comprises at least one artificial intelligence model that generates a morphed version of one or more of the image data files to establish one or more morphed image data files in response to user input comprising one or more proposed changes in a parameter associated with a facial feature.

34. Canceled.

35. Canceled.

36. The system of claim 30, wherein the system further comprises at least one artificial intelligence model that evaluates the sufficiency of user image data file input.

37. Canceled.

38. The system of claim 30, wherein the system comprises one or more artificial intelligence models that evaluate the efficacy of one or more system prompts, one or more system user instructions, one or more system outputs, or a combination thereof.

39. Canceled.

40. Canceled.

41. A computer system for facilitating aesthetic modification surgery patient and medical practitioner consultation comprising a computerized device comprising(1) an interface that facilitates the collection of user input and transmission of the user input to a computer component comprising a computer component processor component that performs one or more functions on the input and returns output to the user through the interface;(2) a user interface processing component that performs one or more functions locally on the computerized device; and(3) a memory component that stores data and system instructions to be carried out by the user interface processing component, the computer component processor component, or both,AMENDED SHEET (ARTICLE 19)301 wherein the computer component processor component comprises one or more artificial intelligence models that are specifically trained to recognize facial features, to modify facial images to reflect the likely outcome of a surgical aesthetic modification procedure, or both, and further wherein (a) the one or more artificial intelligence models specifically trained to recognize facial features comprise a facial feature recognition artificial intelligence module (FFRAI); (b) the user interface processor component, computer component processor component, or both facilitate the application of a face image morphing function, the image morphing function carried out in part by a face imaging morphing artificial intelligence model (FIMAIM) trained to generate morphed facial images based on the expected parameters of a surgical aesthetic modification procedure; (c) the face image morphing function modifies one or more of image data files provided by a system user according to one or more preprogrammed instructions or one or more artificial intelligence models in a manner resulting in one or more initial morphed facial image files each expected to correspond with the outcome of performing the surgical aesthetic modification procedure according to the one or more preprogrammed instructions or the one or more artificial intelligence models; and (d) the user interface processing component facilitates the modulation of one or more parameters associated with one or more selected facial feature elements from among facial features mapped by the FFRAI to generate one or more secondarily morphed facial image files.

42. The system of claim 41, wherein the system comprises at least two distinct facial feature recognition artificial intelligence models, wherein each of the at least two distinct facial feature recognition artificial intelligence models is trained to recognize one or more facial features in different portions of the face.

43. The system of claim 41, wherein the system further comprises at least one artificial intelligence model that evaluates the sufficiency of user image data file input.

44. The system of claim 41, wherein the system comprises one or more artificial intelligence models that evaluate the efficacy of one or more system prompts, one or more system user instructions, one or more system outputs, or a combination thereof.AMENDED SHEET (ARTICLE 19)30245. The system of claim 41, wherein the system comprises a medical practitioner user interface device that comprises a medical practitioner interface device processor component, a medical practitioner device memory component, a medical practitioner device data transmission component, and a medical practitioner interface device interface component, wherein the medical practitioner device interface facilitates the display of one or more image data files which are processed by the computer component processor component and which comprise procedure- related output comprising information that can direct the medical practitioner in performing one or more surgical aesthetic modification procedures.AMENDED SHEET (ARTICLE 19)STATEMENT UNDER ARTICLE 19 (1)The International Search Report for the present Application, dated November 12, 2024, having examined all claims originally filed, identifies claims 4, 5, 7, 8, 10, 12, 15, 16, 18, 20, 24- 26, and 29 as allowable.In the claims as amended under Article 19, the requirements of claim 4 and claim 2 (on which claim 4 depends) are incorporated into independent claim 1. This amendment to independent claim 1 renders claim 1 allowable. Accordingly, claims 2 and 4 are canceled and the dependencies of claims 5, 7, and 10 are amended to address the cancelation of these claims.Notably, claim 4 as originally examined was cited in the ISR as lacking clarity in its recitation of ''the expected parameters,” (emphasis added). It was interpreted during examination as “expected parameters.” The incorporation of the element(s) of claim 4 into claim 1 described herein addresses this lack of clarity by adopting such language.Further, the requirements of claim 29 and claim 27 (on which claim 29 depends) are incorporated into independent claim 21. This amendment renders claim 21 allowable. Accordingly, claims 27 and 29 are canceled.The requirements of claims 40 and claims 37, 32, and 31 (upon which claim 40 depends either directly or indirectly) are incorporated into claim 30. Assuming arguendo that the rejection of this claim in the ISR is correct, all six cited prior art references would be required to establish a rejection of the amended claim. The amendment(s) place(s) claim 30 in a stronger position for re-examination and ultimate allowance at the national stage.New claim 41 is directed to a system comprising specific components of system(s) described in both the original method-directed independent claim 1 and the original system- directed independent claim 30, and, further, incorporates the limitations of dependent claim 4 as originally presented and which was identified as allowable. New claim 41 is a system-directed claim designed to adhere more closely to the system components of now allowable method claims. Given the allowability of amended claim 1, the Applicant expects claim 41 to likewise be allowable.New dependent claims 42 - 45 each depend on new independent claim 41. New claims 42 - 44 repeat the content of select system-directed dependent claims originally presented. New304 claim 45 addresses the medical practitioner device element of a system, e.g., as present in claim 30 as originally presented (and in claim 30 as amended). Dependent claims 42 - 45 are intended simply to further define the claimed system and further distinguish it from the cited art.The amendments to the claims made under Article 19 described herein have no impact on the description or the drawings.

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