Novel heterocyclic compound for selectively regulating cannabinoid CB1 function

Abstract

Provided is a novel heterocyclic compound having a regulatory effect on CB1 signaling pathway abnormalities. Specifically provided is a compound having a structure as shown in formula (I) or a pharmaceutically acceptable salt, a solvate, a hydrate, an isotope substituent or an isomer thereof as a CB1 target regulator.

Description

Novel heterocyclic compounds for selective modulation of cannabinoid CB1 function

[0001] This application requires the applicant to:

[0002] Priority benefit of the prior application, patent application number 202311053936.6, filed with the State Intellectual Property Office of China on August 21, 2023, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0003] Priority benefit of the prior application, patent application number 202311098622.8, filed with the State Intellectual Property Office of China on August 29, 2023, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0004] Priority benefit of the prior application, patent application number 202311202822.3, filed with the State Intellectual Property Office of China on September 18, 2023, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0005] Priority benefit of the prior application, patent application number 202311838739.5, filed with the State Intellectual Property Office of China on December 28, 2023, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0006] Priority benefit of the prior application, patent application number 202410336861.0, filed with the State Intellectual Property Office of China on March 22, 2024, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0007] Priority benefit of the prior application, patent application number 202410360934.X, filed with the State Intellectual Property Office of China on March 27, 2024, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0008] Priority benefit of the prior application, patent application number 202410709443.1, filed with the State Intellectual Property Office of China on June 3, 2024, entitled “Novel heterocyclic compounds for selectively modulating cannabinoid CB1 function”;

[0009] The entirety of the prior application is incorporated into the present disclosure by reference. Technical Field

[0010] The present invention belongs to the field of medicinal chemistry and specifically includes novel heterocyclic compounds that can selectively regulate CB1 function, compositions containing such compounds, and methods for using such compounds to prepare drugs for treating or preventing diseases related to abnormalities in CB1 genes / proteins or signaling pathways (such as obesity, diabetes, metabolic syndrome, and the like). Background Art

[0011] There are two subtypes of cannabinoid receptors: CB1 and CB2. It is generally believed that CB1 activation can increase appetite, promote fat synthesis and storage, inhibit the function of insulin and leptin, and promote inflammation and fibrosis. Studies have found that knocking out the CB1 receptor gene in mice can reduce insulin and leptin levels in their blood and improve insulin and leptin resistance, indicating that CB1 receptor stimulation plays an important role in the development of diet-induced obesity. Inhibiting CB1 receptors can effectively reduce the body's food intake and increase energy expenditure. Therefore, CB1 has become a popular target for the treatment of obesity and metabolic disorders, and some drugs, such as rimonabant, have entered clinical trials or are on the market.

[0012] However, the cannabinoid receptor CB1 is one of the most highly expressed G protein-coupled receptors (GPCRs) in the human central nervous system, primarily located in the brain, spinal cord, and peripheral nervous system. In addition, it is widely distributed in adipose tissue, liver, muscle, gastrointestinal tract, etc. Studies have found that most existing drugs under development have insufficient efficacy and high safety risks, especially central nervous system-related side effects, which limit the use of such drugs. Rimonabant received marketing approval from the European Medical Agency (EMA) in 2006, but was soon banned due to potential psychiatric side effects such as anxiety, depression, and suicidal tendencies. Therefore, there is an urgent need to develop pure peripheral CB1 modulators that cannot penetrate the brain and do not act on the central nervous system, so as to avoid CNS-related side effects.

[0013] Technical Effects

[0014] The inventors unexpectedly discovered that some of the novel heterocyclic compounds of formula (I) of the present invention not only have significant selective inhibition of CB1 but are also essentially unable to penetrate the blood-brain barrier. Compared to similar patented reference compounds with known structures, they also have higher efficacy and safety profiles, better pharmacokinetic properties (including better permeability, lower clearance, longer T1 / 2, and higher leakage), and bioavailability. Compared to the clinically investigated compound of similar structure INV-202, representative compounds of the present invention, such as MDR-001-305-3, not only have similar efficacy but also have better PK (lower clearance, higher leakage, longer half-life, and greater bioavailability). More importantly, their brain penetration rate is much lower than INV-202, and they are expected to have no central nervous system side effects or a lower risk of potential central nervous system side effects. It is expected that MDR-001-305-3 will have better human PK properties and be more suitable as a drug candidate for the prevention or treatment of diseases related to the CB1 target and its signaling pathway.

[0015] Summary of the Invention

[0016] The object of the present invention is to provide a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, enantiomer and isotope-substituted product thereof.

[0017] in,

[0018] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0019] X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(Rd1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0020] X1 is independently selected from N or CR1;

[0021] R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3- 10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents;

[0022] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0023] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0024] M is arbitrarily and independently selected from

[0025] L is selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3)-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0026] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0027] Y is arbitrarily and independently selected from O, S or NR;

[0028] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0029] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0030] Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3- 10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0031] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0032] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、Rd2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0033] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0034] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0035] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0036] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0037] r is an integer arbitrarily selected from 0, 1 and 2.

[0038] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (IA):

[0039] in,

[0040] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0041] X is arbitrarily and independently selected from -C(R d1)(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0042] R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3- 10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents;

[0043] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0044] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0045] M is arbitrarily and independently selected from

[0046] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1)-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0047] Y is arbitrarily and independently selected from O, S or NR;

[0048] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0049] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0050] Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3- 10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0051] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0052] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0053] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0054] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0055] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0056] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5

[0057] r is an integer arbitrarily selected from 0, 1 and 2.

[0058] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (IB),

[0059] in,

[0060] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0061] X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0062] R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3- 10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents;

[0063] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 3-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6radical substitution of cycloalkyl groups;

[0064] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0065] M is arbitrarily and independently selected from

[0066] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(Rd1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0067] Y is arbitrarily and independently selected from O, S or NR;

[0068] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0069] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0070] Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3- 10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0071] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0072] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0073] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0074] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0075] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0076] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5

[0077] r is an integer arbitrarily selected from 1, 1 and 2;

[0078] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (IC),

[0079] in,

[0080] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0081] X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2)-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0082] R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3- 10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10Substitution of heterocyclic groups by substituents;

[0083] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3- 10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2- 10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 3-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0084] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0085] M is arbitrarily and independently selected from

[0086] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0087] Y is arbitrarily and independently selected from O, S or NR;

[0088] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0089] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0090] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0091] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C3-6 radical substitution of cycloalkyl groups;

[0092] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0093] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0094] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0095] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0096] r is an integer arbitrarily selected from 0, 1 and 2.

[0097] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (ID),

[0098] in,

[0099] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0100] X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1)(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0101] R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents;

[0102] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0103] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0104] M is arbitrarily and independently selected from

[0105] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0106] Y is arbitrarily and independently selected from O, S or NR;

[0107] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0108] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0109] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0110] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、Rd2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0111] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0112] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0113] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0114] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0115] r is an integer arbitrarily selected from 0, 1 and 2.

[0116] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (IE):

[0117] in,

[0118] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0119] X is arbitrarily and independently selected from -C(R d1)(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0120] R0 is preferably selected from the M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents;

[0121] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0122] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0123] M is arbitrarily and independently selected from

[0124] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(Rd6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0125] Y is arbitrarily and independently selected from O, S or NR;

[0126] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0127] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; preferably aryl, heteroaryl, heterocyclic group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0128] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0129] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、Rd2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0130] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0131] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0132] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0133] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0134] r is an integer arbitrarily selected from 0, 1 and 2.

[0135] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (IF),

[0136] in,

[0137] Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X.

[0138] X is arbitrarily and independently selected from -C(R d1)(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0139] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0140] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C3-6 cycloalkyl or heterocycloalkyl substitution;

[0141] M is arbitrarily and independently selected from

[0142] Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(Rd1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0143] Y is arbitrarily and independently selected from O, S or NR;

[0144] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0145] R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10Alkyl substituted carboxyl or carboxyl substitute or M group; preferably aryl, heteroaryl, heterocyclic group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0146] Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3- 10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0147] R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0148] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0149] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0150] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0151] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0152] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0153] r is an integer arbitrarily selected from 0, 1 and 2.

[0154] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (1-IE),

[0155] in,

[0156] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0157] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(Rd2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0158] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0159] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0160] M is arbitrarily and independently selected from

[0161] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0162] Y is arbitrarily and independently selected from O, S or NR;

[0163] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0164] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C1-3 Alkyl, C 1-3 alkoxy;

[0165] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0166] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0167] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0168] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0169] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0170] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0171] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (1-IF),

[0172] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0173] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(Rd3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0174] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0175] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, pentafluoride sulfur, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0176] M is arbitrarily and independently selected from

[0177] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R 12 )O-、-NHC(Rd1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0178] Y is arbitrarily and independently selected from O, S or NR;

[0179] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0180] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0181] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, Ra The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0182] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0183] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0184] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0185] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0186] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0187] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (2-IA),

[0188] in,

[0189] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0190] L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0191] X1 is independently selected from N or CR1

[0192] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3- 10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2- 10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0193] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0194] M is arbitrarily and independently selected from

[0195] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(Rd1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0196] Y is arbitrarily and independently selected from O, S or NR;

[0197] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0198] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0199] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0200] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0201] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0202] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0203] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0204] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0205] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (2-IA),

[0206] in,

[0207] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0208] L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(Rd2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0209] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0210] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, sulfur pentafluoride, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0211] M is arbitrarily and independently selected from

[0212] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0213] Y is arbitrarily and independently selected from O, S or NR;

[0214] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0215] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0216] R a and R bAny independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0217] Every R d1 、R d2 、R d3 、R d4 、Rd5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0218] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0219] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0220] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0221] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0222] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (2-IB),

[0223] in,

[0224] Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring;

[0225] L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NRd5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0226] X1 is arbitrarily and independently selected from CR1 or N;

[0227] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0228] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0229] M is arbitrarily and independently selected from

[0230] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(Rd1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0231] Y is arbitrarily and independently selected from O, S or NR;

[0232] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0233] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0234] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, Ra The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0235] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0236] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0237] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0238] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0239] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0240] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (2-IC),

[0241] in,

[0242] Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring;

[0243] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(Rd2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0244] X1 is arbitrarily and independently selected from CR1 or N;

[0245] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0246] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0247] M is arbitrarily and independently selected from

[0248] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0249] Y is arbitrarily and independently selected from O, S or NR;

[0250] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0251] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0252] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0253] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0254] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0255] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0256] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0257] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (2-ID),

[0258] in,

[0259] Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring;

[0260] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(Rd2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0261] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0262] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0263] M is arbitrarily and independently selected from

[0264] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0265] Y is arbitrarily and independently selected from O, S or NR;

[0266] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0267] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0268] R a and Rb Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0269] Every R d1 、R d2 、R d3 、R d4、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0270] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0271] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0272] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0273] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0274] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (2-IE):

[0275] in,

[0276] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0277] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5)-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0278] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3- 10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2- 10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0279] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0280] M is arbitrarily and independently selected from

[0281] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2)NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0282] Y is arbitrarily and independently selected from O, S or NR;

[0283] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0284] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0285] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0286] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0287] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0288] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0289] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0290] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0291] and R and A are not benzene rings at the same time, or when R and A are benzene rings at the same time, any two adjacent R1 together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group;

[0292] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (2-IF),

[0293] in,

[0294] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0295] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1)-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0296] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0297] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0298] M is arbitrarily and independently selected from

[0299] Z is independently selected from absent, C(R d1 )(R d2 ), O, NRd1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0300] Y is arbitrarily and independently selected from O, S or NR;

[0301] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0302] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0303] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0304] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0305] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0306] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0307] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0308] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0309] Provided that when any two adjacent R1's together with the atoms to which they are attached do not form a 4-30 membered heteroaryl, a 4-30 membered saturated or partially saturated cycloalkyl, or a 4-30 membered saturated or partially saturated heterocyclic group, or R d4 Not hydrogen, or R d4 is hydrogen, but R d1 is alkyl, haloalkyl, deuterated alkyl, cycloalkyl, alkylthio or cycloalkylthio;

[0310] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (2-IG),

[0311] in,

[0312] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0313] L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(Rd2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0314] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0315] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0316] M is arbitrarily and independently selected from

[0317] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0318] Y is arbitrarily and independently selected from O, S or NR;

[0319] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0320] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0321] R3 is independently selected from deuterium, C 1-10 Alkyl, C2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkoxy, C 2-10 heteroalkyl, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino, -COOH, C 3-10 Saturated / partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic, aryl, heteroaryl, C 3- 10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R3 is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0322] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0323] Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1- 10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0324] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0325] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0326] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0327] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0328] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (3-IA),

[0329] in,

[0330] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0331] L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(Rd2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0332] L0, L1, L2, L3, L4 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2)C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0333] X1 and X2 are independently selected from N or CR1;

[0334] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0335] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0336] M is arbitrarily and independently selected from

[0337] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0338] Y is arbitrarily and independently selected from O, S or NR;

[0339] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0340] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and - NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0341] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0342] Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0343] Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1- 6 alkoxy is optionally substituted by 1 to more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0344] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0345] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0346] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0347] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

[0348] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (3-IA),

[0349] in,

[0350] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0351] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0352] L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )R(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d 1)(Rd2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0353] X1 and X2 are independently selected from N or CR1;

[0354] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3- 10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2- 10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0355] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0356] M is arbitrarily and independently selected from

[0357] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(Rd2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with one or more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0358] Y is arbitrarily and independently selected from O, S or NR;

[0359] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0360] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0361] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0362] Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0363] Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1- 6 alkoxy is optionally substituted by 1 to more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0364] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0365] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0366] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0367] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0368] t is an integer arbitrarily selected from 0, 1, 2, and 3.

[0369] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (3-IB),

[0370] in,

[0371] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0372] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2)C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0373] L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(Rd1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0374] X1 and X2 are independently selected from N or CR1;

[0375] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0376] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0377] M is arbitrarily and independently selected from

[0378] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0379] Y is arbitrarily and independently selected from O, S or NR;

[0380] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0381] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0382] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0383] Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0384] Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1- 6 alkoxy is optionally substituted by 1 to more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0385] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0386] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0387] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0388] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0389] t is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

[0390] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has the structure of formula (3-IC),

[0391] in,

[0392] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0393] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(Rd2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0394] L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(Rd1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0395] X1 and X2 are independently selected from N or CR1;

[0396] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0397] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0398] M is arbitrarily and independently selected from

[0399] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0400] Y is arbitrarily and independently selected from O, S or NR;

[0401] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0402] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C1-3 Alkyl, C 1-3 alkoxy;

[0403] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0404] Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0405] Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C3-10 cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1- 6 alkoxy is optionally substituted by 1 to more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0406] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0407] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0408] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0409] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0410] t is an integer arbitrarily selected from 0, 1, 2, and 3.

[0411] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (3-ID),

[0412] in,

[0413] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0414] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 ) -、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(Rd2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0415] L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2)NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d5 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0416] X1 and X2 are independently selected from N or CR1;

[0417] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0418] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0419] M is arbitrarily and independently selected from

[0420] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(Rd2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0421] Y is arbitrarily and independently selected from O, S or NR;

[0422] Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0423] Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy;

[0424] R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R aand R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0425] Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0426] Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1- 6 alkoxy is optionally substituted by 1 to more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0427] The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope;

[0428] The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof;

[0429] m is an integer arbitrarily selected from 0, 1, 2, 3, and 4;

[0430] n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5;

[0431] t is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

[0432] In one embodiment of the present invention, the compound or its pharmaceutically acceptable salt, isotope-substituted product or isomer thereof has a structure of formula (3-IE):

[0433] in,

[0434] Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring;

[0435] X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2)C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0436] L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1)P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl;

[0437] X1 and X2 are independently selected from N or CR1;

[0438] Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups;

[0439] Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution;

[0440] M is arbitrarily and independently selected from

[0441] Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d...

Claims

1. A compound represented by formula (I), or a pharmaceutically acceptable salt, solvate, enantiomer or isotope thereof, in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 is independently selected from N or CR1; R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2- 10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from L is selected from -C(R d1 )(R d2 )-, -C(=R d1 )-, -(R d1 )P(=O)-, =C(R d1 )-, NH, -C(R d1 )(R d2 )C(R d1 )(R d2 )-, -C(R d1 )=C(R d1 )-, -C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy; Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups Saturated cycloalkyl or heterocyclic groups substituted by a substituent; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; r is an integer arbitrarily selected from 0, 1 and 2.

2. The compound according to claim 1, or its pharmaceutically acceptable salt, solvate, enantiomer or isotope-substituted product, characterized in that: It has the structure of formula (IA), in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2- 10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy; Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 can be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5 r is an integer arbitrarily selected from 0, 1 and 2; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (IB), in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2- 10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl Substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy; Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl Base, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5 r is an integer arbitrarily selected from 1, 1 and 2; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (IC): in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、- C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; R0 is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2- 10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; r is an integer arbitrarily selected from 0, 1 and 2; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product is characterized in that it has the structure of formula (ID): in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; R0 is independently selected from hydrogen, deuterium, halogen, pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3- 10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; r is an integer selected from 0, 1 and 2; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (IE): in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; R0 is preferably selected from the M group; and the hydrogen on R0 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Substitution of heterocyclic groups by substituents; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated and heterocycloalkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; preferably aryl, heteroaryl, heterocyclic group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; r is an integer arbitrarily selected from 0, 1 and 2; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (IF): in, Ring A is independently absent or represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, or a bridged ring. If Ring A is absent, R2 is directly attached to X. X is arbitrarily and independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, Compounds, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, mercapto, sulfur pentafluoride, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Each L1, L2 or L3 may be the same or different and is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 or L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; R is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute or M group; preferably aryl, heteroaryl, heterocyclic group; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Every R a are the same or different and are arbitrarily and independently selected from hydrogen, deuterium, halogen, cyano, carboxyl, amide, aminoacyl, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further, R a The hydrogen on the 1-2-oxo-1 ... 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; further R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; R6, R7 and R8 are independently selected from hydrogen, deuterium, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or M group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 or R6 and R7 can be linked together to form a 3-30 membered ring structure, which can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; further, the hydrogen atoms on R6, R7 and R8 can be replaced by 1 to multiple atoms selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 or R d7 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-50 Alkenyl acyl, C 10-50 Alkenylalkyl acyl or C 10-50 Alkyl alkenyl alkyl acyl, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3- 10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group or M group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 Alkoxy optional 1 to more selected from hydrogen, deuterium, halogen, oxygen, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; r is an integer arbitrarily selected from 0, 1 and 2.

3. The compound according to claim 1 or 2, or a pharmaceutically acceptable salt, solvate, enantiomer or isotope thereof, characterized in that: It has the structure of formula (1-IE): in, Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Cycloalkyl group group replacement; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 alkyl Base, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1- 6 alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (1-IF): Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N- 2 (C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1- 6 alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

4. The compound according to any one of claims 1 to 3, or a pharmaceutically acceptable salt, solvate, enantiomer or isotope thereof, characterized in that: It has the structure of formula (2-1), in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 is independently selected from N or CR1 Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyethyl Acyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (2-IA), in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two atoms to which R2 can be attached Together they form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, or a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocyclic group is optionally substituted by one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, or OCH2CH3; and the hydrogen on R2 is optionally substituted by one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1、 R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (2-IB), in, Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring; L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 is arbitrarily and independently selected from CR1 or N; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (2-IC): in, Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 is arbitrarily and independently selected from CR1 or N; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with 1 to A plurality of atoms selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (2-ID): in, Rings A and B independently represent a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure. The cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring or a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (2-IE): in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; and R and A are not benzene rings at the same time, or when R and A are benzene rings at the same time, any two adjacent R1 together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (2-IF): Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyethyl Acyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5. Provided that when any two adjacent R1's together with the atoms to which they are attached do not form a 4-30 membered heteroaryl, a 4-30 membered saturated or partially saturated cycloalkyl, or a 4-30 membered saturated or partially saturated heterocyclic group, or R d4 Not hydrogen, or R d4 is hydrogen, but R d1 is alkyl, haloalkyl, deuterated alkyl, cycloalkyl, alkylthio or cycloalkylthio; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the formula (2-IG): in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N- 2 (C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z1 and Z2 is further optionally substituted with one or more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R3 is independently selected from deuterium, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkoxy, C 2-10 heteroalkyl, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino, -COOH, C 3-10 Saturated / partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R3 is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 、R d5 、R d6 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d1 、R d2 、R d3 、R d4 、R d5 、R d6 The hydrogen on the alkyl group is optionally replaced by 1 to more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, Alkylsulfinyl, sulfamoyl, sulfonamide, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 、R d5 、R d6 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5.

5. The compound according to any one of claims 1 to 4, or a pharmaceutically acceptable salt, solvate, enantiomer or isotope thereof, characterized in that: It has the structure of formula (3-I), in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; L and X are each independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L and X is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; L0, L1, L2, L3, L4 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C3 - 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 saturated or partially saturated heterocyclic aromatic group; The hydrogen on L1, L2 and L3 is further optionally substituted by one or more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 and X2 are independently selected from N or CR1; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, -OH, -SH and -NH2, -COOH or selected from C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (3-IA), in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 and X2 are independently selected from N or CR1; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, Compounds, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; t is an integer arbitrarily selected from 0, 1, 2, and 3; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (3-IB), in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 and X2 are independently selected from N or CR1; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2,=O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; t is an integer arbitrarily selected from 0, 1, 2, 3, and 4; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (3-IC): in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 and X2 are independently selected from N or CR1; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2,=O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from the group consisting of absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; t is an integer arbitrarily selected from 0, 1, 2, and 3; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (3-ID): in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; L1, L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L1, L2 and L3 is further optionally substituted by 1 to more substituents, wherein the substituents are arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 and X2 are independently selected from N or CR1; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, wherein the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2,=O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, thiol, C 1-10 Alkyl, C 2-10 Alkenyl, C 2- 10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1- 6 alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; M is arbitrarily and independently selected from Z is independently selected from absent, C(R d1 )(R d2 ), O, NR d1 、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-、-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 4-10 Saturated or partially saturated aromatic groups, C 4-10 Saturated or partially saturated heteroaryl; and the hydrogen on Z is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; Y is arbitrarily and independently selected from O, S or NR; Q represents any 3-20 membered cyclic structure, which can be a monocyclic, bicyclic or tricyclic structure, wherein the cyclic structure can be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; and the hydrogen on the ring Q is optionally replaced by one or more selected from hydrogen, deuterium, halogen, oxo, alkyl, alkenyl, alkynyl, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R may be the same or different and is independently selected from hydrogen, deuterium, halogen, -CN, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, -OH, -SH and -NH2, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonamido or -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated, partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, aryl, heteroaryl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl substitute; and the hydrogen on R is further optionally substituted with 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 alkoxy; R a and R b Any independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group; wherein, the C 1-10 Alkyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 The heterocyclic group is optionally substituted by one or more radicals selected from hydrogen, deuterium, halogen, oxo, CN, OH and C 3-10 Saturated or partially substituted groups substituted by saturated cycloalkyl or heterocyclic substituents; or R a and R b or R a and R2 or R a and R1 can also be connected together to form a 3-30 membered ring structure, wherein the ring structure can be a monocyclic, bicyclic, bridged or spirocyclic structure, and can contain 0 to multiple heteroatoms or unsaturated bonds; furthermore, R a The hydrogen on the alkoxy group is optionally replaced by 1 to more alkoxy groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, oxy, halogenated alkyl, deuterated alkyl, and saturated or partially saturated C 3-6 cycloalkyl or heterocycloalkyl substitution; Every R d1 、R d2 、R d3 、R d4 may be the same or different and are independently selected from hydrogen, deuterium, halogen, NH2, C 1-10 Alkyl, C 2- 10 Alkynyl or C 1-10 Alkoxy, C 1-10 Alkyl acyl, C 1-10 Alkylsulfonyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 Heterocyclic group or Further R d1 、R d2 、R d3 、R d4 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d1 、R d2 、R d3 、R d4 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Every R d5 、R d6 、R d7 may be the same or different and are independently selected from C 1-10 Alkyl, C 2-10 Alkynyl, C 2-10 Heteroalkyl, C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl, C 3-10 Cycloalkyl-substituted C 1-10 Alkyl or C 3-10 Cycloalkyl, C 3-10 Heterocycloalkyl substituted C 3-10 heterocyclic group; further R d5 、R d6 、R d7 The hydrogen on the alkyl group is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, OH, alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, cycloalkylthio, heterocycloalkylthio, heterocycloalkoxy, acetyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoyl, methylsulfonylamino or -COOH and C 3-10 substituted by a saturated or partially saturated cycloalkyl or heterocyclic group; or any R d5 、R d6 、R d7 Each other or / and R1 or R2 and the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen on the heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic alkyl is optionally selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; The heteroatom represents any heteroatom or group independently selected from O, N, S, P, -P=O, S=O or SO2 and its isotope; The halogen is arbitrarily and independently selected from F, Cl, Br, I and isotopes thereof; m is an integer arbitrarily selected from 0, 1, 2, 3, and 4; n is an integer arbitrarily selected from 0, 1, 2, 3, 4 and 5; t is an integer arbitrarily selected from 0, 1, 2, 3, and 4; Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer or isotope substituted product has the structure of formula (3-IE): in, Ring A arbitrarily and independently represents a 3-20 membered cyclic structure, which may be a monocyclic, bicyclic or tricyclic structure, and the cyclic structure may be an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring, a bridged ring or a spirocyclic ring, or a cyclic structure composed of an aromatic ring, a heteroaromatic ring, an alicyclic ring, a heterocyclic ring and a bridged ring; X is independently selected from -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on X is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1- 3 alkoxy, alkenyl, alkynyl; L2 and L3 are each independently selected from the group consisting of absence, a single bond, -C(R d1 )(R d2 )-、-C(=R d1 )-、-(R d1 )P(=O)-、=C(R d1 )-、NH、-C(R d1 )(R d2 )C(R d1 )(R d2 )-、-C(R d1 )=C(R d1 )-、-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-、 -OC(R d1 )(R d2 )-、-C(R d1 )(R d2 )O-、-NHC(R d1 )(R d2 )-、-C(R d1 )(R d2 )NH-、-C(=O)N(R d3 )-、-N(R d4 )-、-C(=NR d5 )-、-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, -C(R d1 )(R d2 )C(=O)-、-C(R d1 )(R d2 )C(=S)-、-C(R d1 )(R d2 )S(=O)-、-C(R d1 )(R d2 )S(=O)2-、-C(=O)C(R d1 )(R d2 )-、-C(=S)C(R d1 )(R d2 )-、-S(=O)C(R d1 )(R d2 )-、-C(R d1 )(R d2 )S(=O)2- or C 3- 10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocycloalkyl, C 5-12 Metaaryl, C 4-12 Saturated or partially saturated heterocyclic aromatic group; and the hydrogen on L2 and L3 is further optionally substituted by 1 to more substituents, the substituents being arbitrarily selected from hydrogen, deuterium, halogen, alkyl, haloalkyl, cyano, cyanoethyl, O=, OH, C 1-3 Alkyl, C 1-3 Alkoxy, alkenyl, alkynyl; X1 and X2 are independently selected from N or CR1; Each R1 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, -CN, -OH, -SH and -NH2, -COOH or selected from C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfamoylamino, methylsulfonylamino or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 Heterocyclic group, C 1-10 Alkyl substituted carboxyl or carboxyl surrogate or M group; and the hydrogen on R1 is optionally replaced by 1 to more selected from H, deuterium, halogen, OCH3, C 1- 10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl or C 1-10 Alkoxy, C 2-10 Heteroalkyl, C 3-10 Saturated or partially saturated cycloalkyl, C 3-10 Saturated or partially saturated heterocyclic alkyl, C 3-10 Cycloalkyl or C 3-10 Heterocycloalkyl substituted C 1-10 Alkyl, C 3-10 Cycloalkyl substituted C 2-10 Heteroalkyl, C 3-10 or any two adjacent R1s together with the atoms to which they are attached form a 5-30 membered heteroaryl, a 3-30 membered saturated or partially saturated cycloalkyl, or a 3-30 membered saturated or partially saturated heterocyclic group, and the hydrogen atoms on the aryl, heteroaryl, saturated or partially saturated cycloalkyl, or heterocyclic group are optionally substituted. The ground is selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2, =O, and saturated or partially saturated C 3-6 Cycloalkyl substituted, and C 1-6 Alkyl and C 1-6 The alkoxy group is optionally substituted with one to more alkyl radicals selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The hydrogen on R1 is optionally replaced by one or more alkyl groups selected from hydrogen, deuterium, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 radical substitution of cycloalkyl groups; Each R2 may be the same or different and is independently selected from hydrogen, deuterium, halogen, sulfur pentafluoride, amino, hydroxyl, mercapto, C 1-10 Alkyl, C 2-10 Alkenyl, C 2-10 Alkynyl, C 1-10 Alkylamino, dialkylphosphonyl, alkylsulfonyl, sulfonyl, alkylsulfinyl, sulfamoyl, sulfonamide, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkyloxy, C 1-10 Alkyl acyl, C 1-10 Alkyloxy, C 1-10 Alkylsulfonyl, C 1-10 Alkylsulfinyl, C 3-10 Cycloalkylamino, C3-10 heterocycloalkylamino, C 3-10 Cycloalkoxy, C 3-10 Heterocycloalkoxy, C 3-10 Cycloalkyl acyl, C 3-10 Cycloalkoxyacetyl, C 3-10 Cycloalkylsulfonyl and C 3-10 Cycloalkylsulfinyl, -YQ or M group; or optionally two R2 can be taken together with the atoms to which they are attached to form a 5-6 membered aryl or heteroaryl, a 3-8 membered saturated or partially saturated cycloalkyl, a 3-8 membered saturated or partially saturated heterocyclic group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclic group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, oxo, CN, CF3, OH, OCH3, OCH2CH3; and the hydrogen on R2 is optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, -CN, -OH, CF3, C 1-6 Alkyl, C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 alkyl)2...

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