Wearable noninvasive microwave glucometer

Abstract

The present disclosure relates to the field of noninvasive glucose monitoring, and specifically, to a wearable noninvasive microwave glucometer. According to the present disclosure, an active Fano resonance-based glucose sensor (11) and a glucose monitoring system (12) are integrated, such that the whole noninvasive microwave glucometer features compactness, wearability, and high sensitivity. Moreover, the active Fano resonance-based glucose sensor (11) monitors the blood glucose concentration on the basis of a microwave signal generated by a microwave signal generation-processing unit, and can thus achieve noninvasive, real-time glucose monitoring in a human and hypoglycemia alarm. The arrangement of the active Fano resonance-based glucose sensor (11), a power supply unit (14), the microwave signal generation-processing unit, and a screen (15) can improve the resolution and sensitivity of blood glucose monitoring, thereby meeting the clinical precision requirements.

Description

A wearable non-invasive microwave blood glucose meter

[0001] This application claims priority to the Chinese patent application filed with the China Patent Office on February 20, 2024, with application number 2024101885792 and invention name “A wearable non-invasive microwave blood glucose meter”, the entire contents of which are incorporated by reference into this application. Technical Field

[0002] The present invention relates to the field of non-invasive blood glucose monitoring, and in particular to a wearable non-invasive microwave blood glucose meter. Background Art

[0003] Diabetes is one of the most prevalent chronic diseases worldwide. Effective blood glucose management can significantly improve patient outcomes and reduce the incidence of complications. Currently, the main methods for blood glucose monitoring include traditional fingertip blood glucose meters (BGM) and continuous glucose monitoring systems (CGM). BGM typically uses fingertip blood samples, which is relatively accurate, but carries a certain degree of pain and infection risk. The single blood glucose value measured by BGM is not representative of the complete blood glucose trend. Patients experience blind spots during the night, which can easily miss hypoglycemia and hyperglycemia peaks, making continuous, real-time blood glucose monitoring difficult to implement, effectively detecting abnormal blood glucose levels. CGM uses a subcutaneous sensor to measure interstitial fluid glucose concentration. Based on the correlation between interstitial fluid glucose and blood glucose concentrations, an algorithm is used to convert this concentration into a blood glucose reading. This allows for 24-hour continuous monitoring and accurate, real-time display of blood glucose fluctuations. However, CGM's indirect measurement requires an algorithm to convert interstitial fluid glucose levels into real-time blood glucose levels, which can be time-consuming and relatively expensive. Non-invasive continuous blood glucose monitoring devices offer an effective solution, but current photoelectric and microwave-based non-invasive blood glucose monitoring systems suffer from insufficient measurement accuracy. Therefore, there is an urgent need to develop low-cost, high-precision, non-invasive continuous blood glucose monitoring equipment, and low-cost, extremely high sensitivity, non-invasive microwave sensors are the most critical part.

[0004] Microwave sensors are a non-invasive sensing technology used in blood glucose testing by measuring the dielectric properties of blood containing glucose molecules. When the glucose concentration in the blood changes, the dielectric properties of the blood change, and the microwave signals interacting with the blood also undergo specific changes. These signals can be captured and analyzed by the microwave sensor, and the blood glucose concentration can be calculated. Laboratories typically use vector network analyzers to measure blood glucose concentrations, but vector network analyzers are large and expensive, and require certain professional knowledge and operating skills, making them difficult to implement on a large scale. Therefore, a wearable, non-invasive blood glucose monitor is needed to enable non-invasive detection of blood glucose concentration in the human body.

[0005] Summary of the Invention

[0006] In order to solve the above problems existing in the prior art, the present invention provides a wearable non-invasive microwave blood glucose meter to achieve non-invasive detection of human blood glucose concentration.

[0007] To achieve the above object, the present invention provides the following solutions:

[0008] A wearable non-invasive microwave blood glucose meter comprises: an active Fano resonant blood glucose sensor, a blood glucose monitoring system, and a watch strap; the active Fano resonant blood glucose sensor and the blood glucose monitoring system are integrated and fixedly mounted on the watch strap;

[0009] The blood glucose monitoring system includes: a screen, a power supply unit, and a microwave signal generation-processing unit; the screen, the power supply unit, and the active Fano resonant blood glucose sensor are all connected to the microwave signal generation-processing unit;

[0010] The active Fano resonant blood glucose sensor is used to monitor the blood glucose signal based on the microwave signal generated by the microwave signal generation-processing unit; the microwave signal generation-processing unit is used to obtain the blood glucose monitoring result based on the blood glucose signal monitored by the active Fano resonant blood glucose sensor; the screen is used to display the blood glucose monitoring result; and the power supply unit is used to provide the required electrical energy.

[0011] Optionally, the active Fano resonant blood glucose sensor comprises: a first dielectric base layer, a second metal grating structure layer, a metal coupling patch, a first metal grating structure layer, a microstrip line metal excitation layer, a second dielectric base layer, a metal backplane layer and an active structure;

[0012] The second metal grating structure layer, the metal coupling patch, and the first metal grating structure layer are all arranged on one end face of the first dielectric base layer; the metal coupling patch is coupled with the second metal grating structure layer; the second metal grating structure layer is coupled with the first metal grating structure layer; the metal coupling patch is connected to the active structure; a groove is provided at a relative position on the edge of the first dielectric base layer, and the groove is used to set the microstrip line metal excitation layer; one end face of the second dielectric base layer is bonded to the other end face of the first dielectric base layer; the metal backplane layer is bonded to one end face of the second dielectric base layer.

[0013] Optionally, periodic grooves are etched on the surface of the first metal grating structure layer and the surface of the second metal grating structure layer.

[0014] Optionally, the second metal grating structure layer and the first metal grating structure layer are coupled to generate a resonant mode.

[0015] Optionally, the active structure includes: a low noise amplifier module and a phase shifter module;

[0016] One end of the metal coupling patch is connected to the input port of the low noise amplifier module; the output port of the low noise amplifier module is connected to the input port of the phase shifter module; and the output port of the phase shifter module is connected to the other end of the metal coupling patch.

[0017] Optionally, the low noise amplifier module uses a low noise amplifier chip of model TRF37C75.

[0018] Optionally, the phase shifter module uses a six-bit digital phase shifter chip with model number HMC649ALP6E.

[0019] Optionally, the microwave signal generation-processing unit includes: a main control module, a digital-to-analog conversion module, a voltage-controlled oscillator module, an attenuator module and a detector module;

[0020] The main control module is connected to the digital-to-analog conversion module, the voltage-controlled oscillator module and the screen respectively; the digital-to-analog conversion module is connected to the voltage-controlled oscillator module; the voltage-controlled oscillator module is connected to the attenuator module; the attenuator module is connected to the active Fano resonant blood glucose sensor; the active Fano resonant blood glucose sensor is connected to the detector module;

[0021] The main control module is used to generate the digital signal required by the digital-to-analog conversion module; the digital-to-analog conversion module is used to generate a voltage signal based on the digital signal; the voltage-controlled oscillator module is used to generate a radio frequency signal based on the voltage signal; the attenuator module is used to generate an attenuated radio frequency transmission signal based on the radio frequency signal; the active Fano resonant blood glucose sensor is used to monitor the blood glucose concentration based on the attenuated radio frequency transmission signal; the detector module is used to receive the radio frequency output signal of the active Fano resonant blood glucose sensor and convert the radio frequency output signal into a voltage signal; the main control module generates the blood glucose test result based on the voltage signal converted from the radio frequency output signal, and displays it on the screen.

[0022] Optionally, the microwave signal generating and processing unit further comprises: a power management module; the power management module is connected to the power supply unit and the main control module respectively;

[0023] The power management module is used to convert the voltage provided by the power supply unit.

[0024] Optionally, the blood glucose monitoring system is configured as a printed circuit board.

[0025] Optionally, the wearable non-invasive microwave blood glucose meter is fixed on the wrist, arm, ankle, calf, thigh or abdomen.

[0026] According to the specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0027] The present invention integrates an active Fano resonant blood glucose sensor and a blood glucose monitoring system into an integrated device and secures them to a watchband, resulting in a miniaturized and wearable device. Furthermore, the active Fano resonant blood glucose sensor monitors blood glucose concentration based on microwave signals generated by a microwave signal generation and processing unit, enabling noninvasive, real-time monitoring of blood glucose levels. The combination of a screen, power supply unit, and microwave signal generation and processing unit improves the resolution and sensitivity of blood glucose monitoring to meet clinical accuracy requirements.

[0028] Figures in the specification

[0029] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0030] FIG1 is a schematic structural diagram of a wearable non-invasive microwave blood glucose meter provided by the present invention;

[0031] FIG2 is a circuit diagram of a power supply unit of a blood glucose monitoring system provided by the present invention;

[0032] FIG3 is a circuit diagram of the MCU portion of the blood glucose monitoring system provided by the present invention;

[0033] FIG4 is a circuit diagram of a phase shifter module in a blood glucose monitoring system provided by the present invention;

[0034] FIG5 is a circuit diagram of a low-noise amplifier module in a blood glucose monitoring system provided by the present invention;

[0035] FIG6 is a circuit diagram of a digital-to-analog conversion module in a blood glucose monitoring system provided by the present invention;

[0036] FIG7 is a circuit diagram of a voltage-controlled oscillator module in the blood glucose monitoring system provided by the present invention;

[0037] FIG8 is a circuit diagram of an attenuator module in a blood glucose monitoring system provided by the present invention;

[0038] FIG9 is a circuit diagram of a detector module in a blood glucose monitoring system provided by the present invention;

[0039] FIG10 is a functional structure diagram of the blood glucose monitoring system provided by the present invention;

[0040] FIG11 is a schematic structural diagram of an active Fano resonant blood glucose sensor provided by the present invention;

[0041] FIG12 is a schematic diagram of a human blood glucose test according to the present invention;

[0042] FIG13 is a diagram showing experimental results of glucose solution testing provided by the present invention;

[0043] FIG14 is a diagram showing the experimental results of the present invention when performing blood sugar testing on a human body.

[0044] Explanation of symbols:

[0045] First dielectric base layer—1, second metal grating structure layer—2, metal coupling patch—3, first metal grating structure layer—4, microstrip line metal excitation layer—5, second dielectric base layer—6, metal backplane layer—7, low-noise amplifier module—8, phase shifter module—9, watch strap—10, active Fano resonant blood glucose sensor—11, blood glucose monitoring system—12, electronic device—13, power supply unit—14, screen—15, cable—16, power cord—17, wrist—18, attenuator module—19, voltage-controlled oscillator module—20, main control module—21, detector module—22. DETAILED DESCRIPTION

[0046] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0047] The purpose of the present invention is to provide a wearable non-invasive microwave blood glucose meter that can realize non-invasive detection of human blood glucose concentration, has the advantages of miniaturization, wearability, high resolution and sensitivity, and can meet clinical accuracy requirements.

[0048] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0049] The wearable, non-invasive microwave blood glucose meter provided by the present invention comprises an active Fano resonant blood glucose sensor, a blood glucose monitoring system, and a watch strap. As shown in FIG1 , the active Fano resonant blood glucose sensor 11 and the blood glucose monitoring system 12 are integrated and fixedly mounted on the watch strap 10 .

[0050] The blood glucose monitoring system 12 includes a screen 15, a power supply unit 14, and a microwave signal generation-processing unit (not shown). The screen 15, the power supply unit 14, and the active Fano resonant blood glucose sensor 11 are all connected to the microwave signal generation-processing unit.

[0051] As one embodiment of the present invention, to further reduce the size of the non-invasive microwave blood glucose meter, the blood glucose monitoring system can be installed on a single PCB board. As shown in Figure 1, from bottom to top, there are an active Fano resonant blood glucose sensor 11, a blood glucose monitoring system 12, the electronic components 13 on the blood glucose monitoring system 12, a power supply unit 14, a screen 15, and a cable 16 and power cord 17 connecting the screen. These components are stacked together to form a non-invasive microwave blood glucose meter with an overall thickness of approximately 10 mm.

[0052] As one embodiment of the present invention, as shown in Figures 2-10 , the microwave signal generation and processing unit provided above includes: a power management module (Power), a main control module 21 (i.e., a microcontroller module, MCU), a digital-to-analog conversion module (i.e., a digital-to-analog converter, DAC), a voltage-controlled oscillator module 20 (VCO), an attenuator module 19 (Attenuator), and a detector module 22 (Detector). In Figure 10 , the active Fano resonant blood glucose sensor is referred to as a blood glucose sensor.

[0053] As shown in Figure 10, the main control module 21 is connected to the digital-to-analog conversion module, the voltage-controlled oscillator module 20, and the screen 15. The voltage-controlled oscillator module 20 is connected to the attenuator module 19. The attenuator module 19 is connected to the active Fano resonant blood glucose sensor. The digital-to-analog conversion module is connected to the detector module 22. The power management module is connected to the power supply unit 14 and the main control module 21.

[0054] As shown in Figure 2, the power management module (Power) is primarily responsible for converting the external power supply into the +3.3V voltage required by the circuit board. As shown in Figure 2, this module uses a voltage regulator (U1) and associated filter capacitors (C1, C2) to ensure stable power output. The diode (D1) and inductor (L5) form a boost converter that processes the input voltage and provides clean, stable power through the voltage regulator (U1). The inverter (U3) outputs a negative voltage, which is used as the negative power input for the phase shifter (U7).

[0055] As shown in Figure 3, the main control module 21 is the core of the circuit board, responsible for controlling and coordinating the operations of the other modules and controlling the operation of the entire non-invasive microwave blood glucose meter. It exchanges data with external devices through a built-in wireless communication interface.

[0056] As shown in Figure 6, the DAC is primarily used to convert digital signals into analog signals for use by other modules. This module is capable of generating precise analog output signals and is a key component of high-precision signal processing.

[0057] The voltage-controlled oscillator module 20 is primarily used to change the output frequency by adjusting the input voltage signal, outputting RF signals of varying frequencies as the RF output signal. The circuit schematic of this module is shown in Figure 7. In practical applications, the voltage-controlled oscillator requires excellent linearity, and its model is not limited.

[0058] Attenuator module 19 is primarily used to reduce the signal amplitude (i.e., attenuate the RF transmit signal) to meet the conditions for injection-locked oscillation, thereby adapting to different signal processing requirements. The circuit schematic of this module is shown in Figure 8. In actual applications, attenuator module 19 needs to have an adjustable function to change the attenuation value, and its model is not limited.

[0059] The detector module 22 is primarily used to extract the power information of the input RF signal, convert it into a voltage signal, and output it, providing data for the system's signal processing and analysis. The circuit schematic of this module is shown in Figure 9. In practical applications, the detector module 22 needs to have a wide power and frequency input range, and its model is not limited.

[0060] Based on the above setup, the entire blood glucose monitoring system was designed with signal integrity between modules in mind, ensuring stable RF signal transmission with minimal crosstalk. Advantages of this design include modularity for ease of maintenance and upgrades, as well as high accuracy and low noise performance, making it suitable for demanding signal processing applications.

[0061] As one embodiment of the present invention, the active Fano resonant blood glucose sensor employs injection-locked oscillation. This active Fano resonant blood glucose sensor comprises a passive resonant structure and an active structure. As shown in Figure 11 , it includes a first dielectric substrate 1, a second metal grating structure layer 2, a metal coupling patch 3, a first metal grating structure layer 4, a microstrip metal excitation layer 5, a second dielectric substrate 6, and a metal backplane layer 7.

[0062] The second metal grating structure layer 2, the metal coupling patch 3, and the first metal grating structure layer 4 are all arranged on one end face of the first dielectric substrate 1. The metal coupling patch 3 is coupled to the second metal grating structure layer 2. The second metal grating structure layer 2 is coupled to the first metal grating structure layer 4. The metal coupling patch 3 is connected to the active structure. A groove is provided at a relative position on the edge of the first dielectric substrate 1, and the groove is used to set the microstrip line metal excitation layer 5. One end face of the second dielectric substrate 6 is bonded to the other end face of the first dielectric substrate 1. The metal backplane layer 7 is bonded to one end face of the second dielectric substrate 6.

[0063] The surfaces of the first metal grating structure layer 4 and the second metal grating structure layer 2 are both etched with periodic grooves. Compared with the ring structure without metal grating grooves, when the radius gap of the metal ring is the same, the grating structure set by the present invention has a stronger electromagnetic wave binding ability and has the advantage of miniaturization. The first metal grating structure layer 4 and the second metal grating structure layer 2, both of which have periodic grooves etched on their surfaces, produce a resonance mode with two resonance points, a resonance peak and a resonance valley, through coupling. The resonance point has a greater resonance intensity and a higher quality factor than the Lorentz resonance mode. In the present invention, the required resonance is excited by coupling the second metal grating structure layer 2 and the first metal grating structure layer 4. The metal coupling patch 3 is connected to the active structure. The metal coupling patch 3 enhances the resonance intensity and reduces the resonance linewidth by coupling with the second metal grating structure 2.

[0064] In practical applications, the thickness of the first dielectric substrate 1 and the second dielectric substrate 6 can be adjusted. The width of the first metal grating structure layer 4 and the second metal grating structure layer 2, the distance between the two metal grooves, and the slit radius of the metal grating for etching the periodic grooves can all be adjusted.

[0065] For example, the first dielectric substrate 1 and the second dielectric substrate 6 can be made of Rogers RO4350, which has a relative dielectric constant of 3.48, a loss tangent of 0.004, and a substrate thickness of 1.0 mm. The thicknesses of the first metal grating structure 4, the second metal grating structure 2, the metal coupling patch 3, the microstrip metal excitation layer 5, and the metal backplane layer 7 can all be set to very small values. For example, the thickness of the first metal grating structure 4, the second metal grating structure 2, the metal coupling patch 3, the microstrip metal excitation layer 5, and the metal backplane layer 7 can be set to 0.035 mm.

[0066] As one embodiment of the present invention, as shown in FIG11 , the active structure includes a low-noise amplifier module 8 (i.e., a low-noise amplifier, LNA) and a phase shifter module 9 (i.e., a phase shifter). The circuit schematic of the low-noise amplifier module is shown in FIG4 , and the circuit schematic of the phase shifter module 9 is shown in FIG5 .

[0067] One end of the metal coupling patch is connected to the input port of the low-noise amplifier module. The output port of the low-noise amplifier module is connected to the input port of the phase shifter module. The output port of the phase shifter module is connected to the other end of the metal coupling patch.

[0068] The low noise amplifier module 8 is mainly used to amplify the received signal while keeping the noise level as low as possible to improve the sensitivity of the system.

[0069] The phase shifter module 9 is mainly used to meet the injection locking condition by changing the phase information of the signal.

[0070] The active part based on the injection-locked oscillation technology is introduced through the second metal grating structure 2, and the phase shift angles of the second metal grating structure 2 and the phase shifter module 9 are adjusted so that the phase meets the oscillation condition.

[0071] In actual application, the low noise amplifier module 8 may use a low noise amplifier chip of Texas Instruments, model TRF37C75, which has a gain of 16 dB, but is not limited thereto.

[0072] The phase shifter module 9 may be a six-bit digital phase shifter chip from Analog Devices, Inc., model HMC649ALP6E, with a minimum phase shift angle of 5.625°, but is not limited thereto.

[0073] Based on the above description, taking the blood glucose test on the human body as an example, the detection effect of the wearable non-invasive microwave blood glucose meter provided by the present invention is explained. Figure 12 shows the actual wearing situation of the non-invasive microwave blood glucose meter when performing blood glucose testing on the human body. The non-invasive microwave blood glucose meter in Figure 12 can be worn on the front of the wrist 18 or the back of the wrist 18 through the strap 10 when performing the test to ensure the accuracy of the measurement results. The screen 15 is used to display the measurement results. The specific content displayed on the screen 15 can be set according to actual needs. Figure 12 is only an example and is not a specific limitation of the final display structure. In addition, the wearable non-invasive microwave blood glucose meter can be flexibly fixed according to needs. It can be fixed not only on the wrist, but also on the arm, ankle, calf, thigh or abdomen.

[0074] The experimental results for glucose solution testing are shown in Figure 13. The horizontal axis shows the changes in glucose solution concentrations. The horizontal axis represents the input control voltage of the voltage-controlled oscillator, which can be converted into frequency information, and the vertical axis represents the output voltage of the detector, which actually represents power information. Figure 13 shows that the non-invasive microwave blood glucose meter provided by the present invention can detect changes in the concentration of a 10 mg / dL glucose solution.

[0075] Figure 14 compares the experimental results of the non-invasive microwave blood glucose monitor provided by the present invention and a blood sampling blood glucose meter. The experimental results shown in Figure 14 primarily measure changes in blood glucose concentration within one hour after a meal. The horizontal axis represents time in minutes, the left vertical axis represents the VCO control voltage information, which actually means frequency information, and the right vertical axis represents the blood glucose level. The experimental results were obtained by collecting fingertip blood using a blood glucose meter, and the unit is mmol / L.

[0076] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0077] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be construed as limiting the present invention.

Claims

1. A wearable non-invasive microwave blood glucose meter, characterized in that: include: Active Fano resonant blood glucose sensor, blood glucose monitoring system and strap; The active Fano resonant blood glucose sensor and the blood glucose monitoring system are integrated and fixedly arranged on the watch strap; The blood glucose monitoring system comprises: a screen, a power supply unit and a microwave signal generating and processing unit; The screen, the power supply unit and the active Fano resonant blood glucose sensor are all connected to the microwave signal generating and processing unit; The active Fano resonant blood glucose sensor is used to monitor blood glucose concentration based on the microwave signal generated by the microwave signal generation-processing unit; the microwave signal generation-processing unit is used to obtain blood glucose monitoring results based on the blood glucose concentration monitored by the active Fano resonant blood glucose sensor; the screen is used to display the blood glucose monitoring results; and the power supply unit is used to provide the required electrical energy.

2. The wearable non-invasive microwave blood glucose meter according to claim 1, characterized in that: The active Fano resonant blood glucose sensor comprises: a first dielectric base layer, a second metal grating structure layer, a metal coupling patch, a first metal grating structure layer, a microstrip metal excitation layer, a second dielectric base layer, a metal backplane layer and an active structure; The second metal grating structure layer, the metal coupling patch, and the first metal grating structure layer are all arranged on one end face of the first dielectric base layer; the metal coupling patch is coupled with the second metal grating structure layer; the second metal grating structure layer is coupled with the first metal grating structure layer; the metal coupling patch is connected to the active structure; a groove is provided at a relative position on the edge of the first dielectric base layer, and the groove is used to set the microstrip line metal excitation layer; one end face of the second dielectric base layer is bonded to the other end face of the first dielectric base layer; the metal backplane layer is bonded to one end face of the second dielectric base layer.

3. The wearable non-invasive microwave blood glucose meter according to claim 2, characterized in that: Periodic grooves are etched on the surface of the first metal grating structure layer and the surface of the second metal grating structure layer.

4. The wearable non-invasive microwave blood glucose meter according to claim 2, characterized in that: The second metal grating structure layer and the first metal grating structure layer are coupled to generate a resonance mode.

5. The wearable non-invasive microwave blood glucose meter according to claim 2, characterized in that: The active structure includes: a low noise amplifier module and a phase shifter module; One end of the metal coupling patch is connected to the input port of the low noise amplifier module; the output port of the low noise amplifier module is connected to the input port of the phase shifter module; and the output port of the phase shifter module is connected to the other end of the metal coupling patch.

6. The wearable non-invasive microwave blood glucose meter according to claim 5, characterized in that: The low noise amplifier module adopts a low noise amplifier chip of model TRF37C75.

7. The wearable non-invasive microwave blood glucose meter according to claim 5, characterized in that: The phase shifter module adopts a six-bit digital phase shifter chip model HMC649ALP6E.

8. The wearable non-invasive microwave blood glucose meter according to claim 1, characterized in that: The microwave signal generation and processing unit includes: a main control module, a digital-to-analog conversion module, a voltage-controlled oscillator module, an attenuator module and a detector module; The main control module is connected to the digital-to-analog conversion module, the voltage-controlled oscillator module and the screen respectively; the digital-to-analog conversion module is connected to the voltage-controlled oscillator module; the voltage-controlled oscillator module is connected to the attenuator module; the attenuator module is connected to the active Fano resonant blood glucose sensor; the active Fano resonant blood glucose sensor is connected to the detector module; The main control module is used to generate the digital signal required by the digital-to-analog conversion module; the digital-to-analog conversion module is used to generate a voltage signal based on the digital signal; the voltage-controlled oscillator module is used to generate a radio frequency signal based on the voltage signal; the attenuator module is used to generate an attenuated radio frequency transmission signal based on the radio frequency signal; the active Fano resonant blood glucose sensor is used to monitor the blood glucose concentration based on the attenuated radio frequency transmission signal; the detector module is used to receive the radio frequency output signal of the active Fano resonant blood glucose sensor and convert the radio frequency output signal into a voltage signal; the main control module generates the blood glucose test result based on the voltage signal converted from the radio frequency output signal, and displays it on the screen.

9. The wearable non-invasive microwave blood glucose meter according to claim 8, characterized in that: The microwave signal generating and processing unit further comprises: a power management module; the power management module is connected to the power supply unit and the main control module respectively; The power management module is used to convert the voltage provided by the power supply unit.

10. The wearable non-invasive microwave blood glucose meter according to claim 1, characterized in that: Blood glucose monitoring system set up as printed circuit board.

11. The wearable non-invasive microwave blood glucose meter according to claim 1, characterized in that: The wearable non-invasive microwave blood glucose meter is fixed on the wrist, arm, ankle, calf, thigh or abdomen.

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