Marker for differentiating carcinomas of colon and rectum from adenomas of colon and rectum and use thereof

Abstract

The present invention belongs to the technical field of diagnosis, and particularly relates to a marker for differentiating carcinomas of the colon and rectum from adenomas of the colon and rectum and the use thereof. Disclosed in the present invention is one or more of 75 markers as a marker for distinguishing carcinomas of the colon and rectum from adenomas of the colon and rectum. By means of detecting the content, expression level, and / or activity of the above markers, differentiation of carcinomas of the colon and rectum from adenomas of the colon and rectum can be achieved.

Description

Markers for distinguishing colorectal cancer from colorectal adenoma and their applications Technical Field

[0001] The present invention belongs to the field of diagnostic technology, and in particular relates to markers for distinguishing colorectal cancer from colorectal adenoma and applications thereof. Background Art

[0002] Colorectal cancer (carcinoma of the colon and rectum) is a common malignant tumor of the gastrointestinal tract. Its incidence and mortality are second only to gastric cancer, esophageal cancer, and primary liver cancer among digestive system malignancies. In recent years, the incidence of colorectal cancer has been increasing year by year. While its etiology is not fully understood, factors such as the environment, diet, and lifestyle (alcohol consumption and smoking) may contribute to the risk. Furthermore, familial polyps, ulcerative colitis, and a family history of tumor inheritance are also high-risk factors for colorectal cancer.

[0003] The development of colorectal cancer progresses through a progression from normal to adenoma to tumor. Some patients may remain in the colorectal adenoma stage for 10-15 years before developing cancer. The existence of the adenoma stage also provides an important time window for early diagnosis and intervention of colorectal cancer. Research has largely focused on screening and identifying molecular markers that can distinguish between normal people and cancer patients. Currently, molecular markers that can detect the progression of colorectal cancer, namely the adenoma-tumor transition, are very scarce. Therefore, identifying molecular markers that can distinguish colorectal adenomas from colorectal cancer is of great significance for the early diagnosis and intervention of colorectal cancer. Summary of the Invention

[0004] The purpose of the first aspect of the present invention is to provide the use of a substance for detecting a marker in the preparation of a product for distinguishing colorectal cancer from colorectal adenoma.

[0005] The second aspect of the present invention aims to provide a marker combination for distinguishing colorectal cancer from colorectal adenoma.

[0006] The third aspect of the present invention aims to provide a product for distinguishing colorectal cancer from colorectal adenoma.

[0007] The fourth aspect of the present invention aims to provide a method for constructing a model for distinguishing colorectal cancer from colorectal adenoma.

[0008] The fifth aspect of the present invention aims to provide a device or system for distinguishing colorectal cancer from colorectal adenoma.

[0009] The sixth aspect of the present invention aims to provide a computer device.

[0010] The seventh aspect of the present invention aims to provide a computer storable medium.

[0011] The purpose of the eighth aspect of the present invention is to provide a method for distinguishing colorectal cancer from colorectal adenoma.

[0012] In order to achieve the above object, the technical solution adopted by the present invention is:

[0013] The first aspect of the present invention provides the use of a substance for detecting a marker in preparing a product:

[0014] The product is used to differentiate colorectal cancer from colorectal adenoma;

[0015] The marker is A, and A includes at least one of B, that is, it can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87 6, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, or 75;

[0016] The B group includes: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA11, ITG AV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, UPB1 (i.e., 75 proteins in Table 1).

[0017] Preferably, the A comprises any 1, 2, 3, 4, 5, 6, 7, or 8 of the Bs.

[0018] Preferably, the A comprises a single marker, and the single marker is any one of the B, such as ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA11, ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1 , PEPD, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, or UPB1.

[0019] Preferably, the single marker is: CLEC3B, IGFBP2, FAP, CEACAM5, AREG, PLXDC2, MEGF9, DPP4, CKB, TNC, CFP, LRG1, ITIH3, FGA, CD34, SERPINA1, HEG1, MAMDC4, MZB1, MCAM, ADAM12, PEPD, AGR3, PTX3, SSC4D, GDF15, ADAMTSL4, ITGA11, NAGPA, CD58, SSBP1, ITGAV, CPM, RTN4R, A POA4, PTH, C1QTNF1, DCXR, UPB1, TINAGL1, CNTN4, IL17RA, MFGE8, CA14, RPGR, ACY1, PKD1, PEAR1, PDIA4, SLAMF8, PCDH7, NCS1, PPY, KRT19, ENPP6, GNAS, LILRA4, RAB37, HPGDS, ESM1, IL1R2, COMP, KHK, or CDH23 (i.e., 64 proteins in Table 2); among them, IGFBP2, CEACAM5, and IL-1R2 in subjects with colorectal cancer are expressed. , AREG, CKB, TNC, LRG1, ITIH3, FGA, SERPINA1, MZB1, ADAM12, PTX3, GDF15, ADAMTSL4, SSBP1, C1QTNF1, TINAGL1, PDIA4, SLAMF8, PPY, KRT19, RAB37, and ESM1 content, expression and / or activity are increased compared with the levels in the subjects with colorectal adenoma, and CLEC3B, FAP, PLXDC2, MEGF9, DPP4, CFP, CD34, and HEG1 are increased in the subjects with colorectal cancer. , MAMDC4, MCAM, PEPD, AGR3, SSC4D, ITGA11, NAGPA, CD58, ITGAV, CPM, RTN4R, APOA4, PTH, DCXR, UPB1, CNTN4, IL17RA, MFGE8, CA14, RPGR, ACY1, PKD1, PEAR1, PCDH7, NCS1, ENPP6, GNAS, LILRA4, HPGDS, IL1R2, COMP, KHK, and CDH23, the expression level and / or activity are decreased relative to those in the subjects with colorectal adenoma.

[0020] Preferably, the single marker is: SERPINA1, AREG, PDIA4, CLEC3B, ADAM12, IGFBP2, ADAMTSL4, PEPD, MAMDC4, FGA, CEACAM5, MEGF9, LRG1, ITIH3, TNC, ITGAV, CD34, CKB, SLAMF8, DPP4, HPGDS, KHK, MCAM, AGR3, DCXR, FAP, PKD1, IL1R2, PTX3, RAB37, PLXDC2, MZB1, CPM, or CFP (i.e., the 34 proteins in Table 3).

[0021] Preferably, the single marker is: SERPINA1, AREG, PDIA4, CLEC3B, ADAM12, or IGFBP2.

[0022] Preferably, the A comprises a combination of 2 markers, and the combination of 2 markers is any 2 of the B.

[0023] Preferably, the 2markers combination is: SERPINA1 and IL17RA, AREG and HEG1, CLEC3B and SERPINA1, AREG and PKD1, AREG and PEPD, PDIA4 and PEPD, PRDX1 and SERPINA1, DCXR and SERPINA1, AREG and CD55, IL1RAP and SERPINA1, ADAM12 and FAP, PLXDC2 and SERPINA1, PEPD and SERPINA1, AREG and CD34, PDIA4 and PKD1, AREG and NCS1, ALCAM and PDIA4, or AREG and MCAM (i.e., the 2markers combination in Table 4).

[0024] Preferably, the A comprises a combination of 3 markers, and the combination of 3 markers is any 3 of the B.

[0025] Preferably, the 3 markers combination is any 3 of C, and the C is: ADAM12, ADAMTSL4, AGR3, ALCAM, AREG, ASPN, CD34, CD55, CEACAM5, CLEC3B, DCXR, FAP, FGA, HEG1, IGFBP2, IL17RA, IL1RAP, ITIH3, LRG1, MAMDC4, MCAM, MEGF9, NCS1, PDIA4, PEPD, PKD1, PLXDC2, PRDX1, PRTN3, SERPINA1, SLAMF8, TBCB, TNC.

[0026] Preferably, the three markers combination is: AREG, PKD1 and DCXR; CEACAM5, FGA and HEG1; AREG, ADAM12 and NCS1; PDIA4, CEACAM5 and HEG1; SERPINA1, IL17RA and PLXDC2; SERPINA1, TBCB and PLXDC2; AREG, FGA and HEG1; PDIA4, PKD1 and PEPD; AREG, CEACAM5 and HEG1; AREG, ADAMTSL4 and PKD1; AREG, ADAM12 and PKD1; PDIA4, PEPD and IL17RA; PDIA4, PEPD and HEG1 ; TNC, MAMDC4 and MCAM; AREG, TNC and PKD1; SERPINA1, CEACAM5 and HEG1; SERPINA1, CLEC3B and IL17RA; SERPINA1, PDIA4 and PLXDC2; PDIA4, FGA and HEG1; ADAM12, AGR3 and IL1RAP; SERPINA1, ADAM12 and PRDX1; PDIA4, PEPD and FAP; AREG, CD34 and DCXR; CEACAM5, ADAMTSL4 and HEG1; ADAM12, CEACAM5 and HEG1; SERPINA1, ASPN and PLXDC2; C EACAM5, FGA and MEGF9; PDIA4, TBCB and FAP; SERPINA1, AREG and PLXDC2; PDIA4, PKD1 and DCXR; SERPINA1, IL1RAP and PLXDC2; TNC, MAMDC4 and PLXDC2; FGA, MAMDC4 and HEG1; SERPINA1, PDIA4 and IL17RA; PDIA4, CEACAM5 and PEPD; PDIA4, CEACAM5 and MEGF9; CEACAM5, SLAMF8 and MEGF9; SERPINA1, CLEC3B and IL1RAP; AREG, SLAMF8 and DCXR; PDIA4, ASPN and HEG1; AREG, FGA and PKD1; FGA, SLAMF8 and HEG1; AREG, MCAM and DCXR; PDIA4, ITIH3 and PKD1; SERPINA1, CEACAM5 and MEGF9; SERPINA1, FGA and HEG1; ADAM12, DCXR and IL1RAP; SERPINA1, ADAM12 and NCS1; PDIA4, MCAM and DCXR; AREG, HEG1 and DCXR; SERPINA1, AREG and IL17RA; SERPINA1, SLAMF8 and DCXR; PDIA4, ASPN and PEPD;SERPINA1, CLEC3B and PRDX1; AREG, TBCB and HEG1; TNC, PKD1 and MAMDC4; PDIA4, PKD1 and MAMDC4; PDIA4, IL17RA and ALCAM; PDIA4, TNC and MCAM; AREG, PDIA4 and PKD1; PDIA4, TNC and IL17RA; AREG, ADAMTSL4 and HEG1; SERPINA1, SLAMF8 and PEPD; ADAM12, PDIA4 and PEPD; ADAM12, ITIH3 and PKD1; AREG, HEG1 and MCAM; SERPINA1, TNC and PLXDC2; C EACAM5, HEG1 and PRDX1; PKD1, SLAMF8 and DCXR; ADAM12, FGA and HEG1; PDIA4, ITIH3 and MCAM; PDIA4, FGA and PKD1; SERPINA1, HEG1 and PLXDC2; AREG, PEPD and HEG1; ADAM12, FGA and CD34; ADAM12, FAP and PRDX1; FGA, TBCB and HEG1; CEACAM5, TNC and MEGF9; SERPINA1, PDIA4 and PKD1; AREG, ASPN and PKD1; ADAM12, FGA and PEPD; SERPINA1, FAP and PR DX1; PDIA4, FGA and PEPD; PDIA4, TNC and PKD1; AREG, PDIA4 and PEPD; SERPINA1, ADAMTSL4 and IL17RA; ADAM12, CD55 and FAP; AREG, ASPN and AGR3; AREG, ASPN and IL17RA; SERPINA1, CEACAM5 and IL17RA; AREG, MEGF9 and NCS1; SERPINA1, ADAM12 and PKD1; CEACAM5, TNC and HEG1; PDIA4, MAMDC4 and PLXDC2; PDIA4, IGFBP2 and PKD1; AREG, TBCB and P KD1; SERPINA1, ADAM12 and IL17RA; ADAM12, CEACAM5 and NCS1; SERPINA1, ADAM12 and CLEC3B; AREG, TNC and MCAM; FGA, IGFBP2 and PKD1; AREG, PKD1 and PEPD; ADAM12, TBCB and FAP; AREG, ITIH3 and PKD1; PDIA4, CEACAM5 and IL17RA; AREG, PKD1 and CD55; TNC, IGFBP2 and MCAM; CEACAM5, SLAMF8 and HEG1; AREG, TBCB and CD55; AREG, FAP and IL1RAP;PDIA4, ITIH3, and CD34; AREG, FGA, and NCS1; ADAM12, FGA, and NCS1; SERPINA1, ADAM12, and PEPD; PDIA4, HEG1, and PLXDC2; SERPINA1, CEACAM5, and PRDX1; SERPINA1, TNC, and IL17RA; AREG, ASPN, and HEG1; AREG, PDIA4, and IL17RA; PDIA4, PEPD, and MCAM; PDIA4, IGFBP2, and CD55; ADAM12, CEACAM5, and MEGF9; AREG, CEACAM5, and PKD1; AREG, PDIA4, and CD3 4;AREG, ADAM12 and CD55;AREG, ADAM12 and DCXR;PDIA4, MEGF9 and PEPD;SERPINA1, PKD1 and DCXR;SERPINA1, CLEC3B and ASPN;AREG, ASPN and MCAM;ADAM12, ITIH3 and CD34;SERPINA1, CLEC3B and PLXDC2;AREG, TNC and NCS1;SERPINA1, CEACAM5 and PKD1;SERPINA1, SLAMF8 and HEG1;AREG, MAMDC4 and PLXDC2;ADAM12, PEPD and FAP;SERPINA1, DCXR and PLXDC2; AREG, ADAMTSL4 and NCS1; AREG, ADAM12 and IL17RA; SERPINA1, AREG and CD55; PDIA4, IGFBP2 and PEPD; SERPINA1, PDIA4 and HEG1; SERPINA1, IL17RA and DCXR; PDIA4, CEACAM5 and PKD1; SERPINA1, SLAMF8 and PLXDC2; AREG, NCS1 and MCAM; SERPINA1, PKD1 and PLXDC2; ADAM12, ASPN and AGR3; SLAMF8, MCAM and DCXR; PDIA4, PEP D and CD34; CEACAM5, IGFBP2 and HEG1; AREG, FGA and MEGF9; PDIA4, CEACAM5 and DCXR; AREG, TNC and HEG1; SERPINA1, TNC and PKD1; SERPINA1, CD34 and DCXR; PDIA4, TBCB and HEG1; SERPINA1, FGA and CLEC3B; ADAM12, CEACAM5 and IL1RAP; SERPINA1, MAMDC4 and PLXDC2; CEACAM5, ITIH3 and HEG1; CEACAM5, TNC and FAP; SERPINA1, CEACAM5 and DCXR;SERPINA1, AREG and DCXR; PDIA4, ASPN and MCAM; ADAM12, ITIH3 and CLEC3B; AREG, MCAM and IL1RAP; ADAM12, CEACAM5 and PRDX1; AREG, ADAMTSL4 and CD55; CEACAM5, TNC and MCAM; AREG, PKD1 and PRTN3; AREG, MAMDC4 and HEG1; SERPINA1, AREG and CLEC3B; AREG, PDIA4 and HEG1; SERPINA1, PRDX1 and PLXDC2; SERPINA1, MEGF9 and IL17RA; SER PINA1, ADAM12 and PLXDC2; AREG, PEPD and NCS1; PDIA4, TBCB and PEPD; ADAM12, TBCB and NCS1; SERPINA1, PDIA4 and MEGF9; SERPINA1, CEACAM5 and IL1RAP; TNC, IGFBP2 and PKD1; PDIA4, CD55 and ALCAM; SERPINA1, AREG and PKD1; AREG, FGA and DCXR; SERPINA1, FAP and PLXDC2; PDIA4, IGFBP2 and ALCAM; SERPINA1, CEACAM5 and PEPD; AREG, AG R3 and IL1RAP; SERPINA1, AGR3 and IL1RAP; ADAM12, FGA and PKD1; AREG, CLEC3B and PKD1; ADAM12, TBCB and PKD1; CEACAM5, TBCB and HEG1; AREG, PDIA4 and DCXR; AREG, HEG1 and IL1RAP; SERPINA1, ADAM12 and IL1RAP; PDIA4, TNC and PLXDC2; PDIA4, SLAMF8 and PEPD; AREG, TNC and PLXDC2; AREG, FGA and MCAM; PDIA4, PKD1 and ALCAM; PDIA4, PKD 1 and PRDX1; ADAM12, FAP and IL1RAP; PDIA4, TBCB and MCAM; SERPINA1, CD34 and IL1RAP; ADAM12, PDIA4 and DCXR; AREG, PKD1 and HEG1; SERPINA1, PEPD and PLXDC2; SERPINA1, HEG1 and PRDX1; PDIA4, DCXR and ALCAM; SERPINA1, ADAM12 and DCXR; SERPINA1, CLEC3B and SLAMF8; AREG, PKD1 and MAMDC4; ADAM12, ASPN and FAP; FGA, MAMDC4 and CD34;AREG, ADAMTSL4 and MCAM; AREG, MAMDC4 and CD55; PDIA4, ADAMTSL4 and PKD1; ADAM12, MAMDC4 and CD34; AREG, PKD1 and ALCAM; ADAMTSL4, SLAMF8 and PEPD; PDIA4, TBCB and PKD1; SERPINA1, IL17RA and CD55; SERPINA1, DCXR and IL1RAP; PDIA4, TBCB and CD34; TNC, ASPN and MCAM; SERPINA1, PKD1 and IL17RA; PDIA4, ITIH3 and PEPD; SERPINA 1. CEACAM5 and PLXDC2; ADAM12, ASPN and HEG1; PDIA4, MAMDC4 and MCAM; SERPINA1, ADAM12 and CD34; PDIA4, IGFBP2 and MCAM; AREG, TBCB and FAP; ADAM12, IL1RAP and ALCAM; CEACAM5, TNC and IL17RA; SERPINA1, TBCB and PRDX1; AREG, ADAM12 and ALCAM; ADAM12, TBCB and IL1RAP; SERPINA1, CLEC3B and CD55; ADAM12, FGA and MAMDC4; PDIA4 , TNC and MEGF9; SERPINA1, ADAMTSL4 and HEG1; AREG, PDIA4 and NCS1; SERPINA1, ADAMTSL4 and PKD1; SERPINA1, PDIA4 and PRDX1; AREG, PDIA4 and CD55; SERPINA1, CEACAM5 and CD34; PDIA4, IL1RAP and ALCAM; SERPINA1, IL17RA and PRDX1; AREG, MAMDC4 and CD34; ADAM12, ITIH3 and NCS1; CEACAM5, FGA and PEPD; AREG, TNC and FAP; SERPINA 1. FGA and IL17RA; AREG, DCXR and IL1RAP; PDIA4, PKD1 and IL17RA; PDIA4, TNC and FAP; FGA, IGFBP2 and HEG1; AREG, IL1RAP and PLXDC2; SERPINA1, CLEC3B and TBCB; ADAM12, PDIA4 and PKD1; AREG, ADAM12 and HEG1; PDIA4, PLXDC2 and ALCAM; ADAM12, PDIA4 and ALCAM; PDIA4, FAP and PRDX1; or SERPINA1, PKD1 and SLAMF8 (i.e., the 3-marker combination in Table 5).

[0027] Preferably, the A comprises a combination of 4 markers, and the combination of 4 markers is any 4 of the B.

[0028] Preferably, the four markers are combined into any four of the Cs.

[0029] Preferably, the four markers combination is: CEACAM5, FGA, PEPD and HEG1; AREG, CEACAM5, FGA and HEG1; ADAM12, CEACAM5, FGA and HEG1; PDIA4, CEACAM5, PEPD, HEG1; CEACAM5, FGA, HEG1 and PRDX1; AREG, PDIA4, DCXR and ALCAM; SERPINA1, CEACAM5, FGA and HEG1; AREG, FGA, HEG1 and IL1RAP; AREG, FGA, PEPD and HEG1; ADAM12, PDIA4, DCXR and ALCAM; PDIA4, PKD1, DCXR, and IL1RAP; SERPINA1, ADAM12, FAP, and PRDX1; PDIA4, TNC, PEPD, and FAP; SERPINA1, PKD1, SLAMF8, and DCXR; PDIA4, PKD1, PEPD, and DCXR; AREG, PDIA4, PKD1, and DCXR; PDIA4, CEACAM5, PKD1, and DCXR; PDIA4, PEPD, FAP, and DCXR; SERPINA1, AREG, IL1RAP, and PLXDC2; PDIA4, TBCB, PEPD, and FAP; AREG, PDIA4, CEACAM5 and HEG1; AREG, ADAM12, FGA and HEG1; SERPINA1, CEACAM5, IL1RAP and PLXDC2; PDIA4, FGA, PKD1 and DCXR; PDIA4, CEACAM5, DCXR and ALCAM; ADAM12, FGA, MAMDC4 and HEG1; PDIA4, FGA, IGFBP2 and PKD1; ADAM12, LRG1, FAP and PRDX1; CEACAM5, TNC, FGA and HEG1; ADAM12, FGA, AGR3 and IL1RAP; SERPINA1, MAMDC4, IL1RAP and PLXDC2; PD IA4, TNC, MCAM and DCXR; SERPINA1, ADAM12, IL1RAP and PLXDC2; ADAM12, CEACAM5, FAP and PRDX1; AREG, ADAM12, PKD1 and DCXR; AREG, PKD1, SLAMF8 and DCXR; TNC, AGR3, MAMDC4 and IL1RAP; ADAM12, TBCB, FAP and PRDX1; PDIA4, CLEC3B, PKD1 and DCXR; PDIA4, FGA, PEPD and HEG1; PDIA4, PEPD, HEG1 and FAP; ADAM12, FGA, FAP and PRDX1;ADAM12, PDIA4, PKD1, and DCXR; PDIA4, SLAMF8, MCAM, and DCXR; PDIA4, DCXR, IL1RAP, and ALCAM; ADAM12, PEPD, FAP, and PRDX1; SERPINA1, AREG, FGA, and HEG1; PDIA4, TNC, IGFBP2, and MCAM; SERPINA1, AREG, PKD1, and DCXR; AREG, TNC, MAMDC4, and NCS1; ADAM12, FAP, PRDX1, and DCXR; AREG, ADAM12, TNC, and NCS1; PDIA4, IGFBP2, PKD1, and DC XR; PDIA4, IL17RA, DCXR and ALCAM; ADAM12, CLEC3B, AGR3 and IL1RAP; CEACAM5, AGR3, SLAMF8 and HEG1; SERPINA1, TNC, DCXR and PLXDC2; FGA, AGR3, SLAMF8 and HEG1; PDIA4, CEACAM5, MEGF9 and PEPD; PDIA4, TNC, MAMDC4 and CD55; CEACAM5, SLAMF8, PEPD and HEG1; SERPINA1, SLAMF8, DCXR and PLXDC2; SERPINA1, PEPD, IL1RAP and P LXDC2; SERPINA1, CEACAM5, CLEC3B, and PRDX1; PDIA4, TNC, ITIH3, and PKD1; ADAM12, FGA, SLAMF8, and NCS1; TNC, CLEC3B, AGR3, and IL1RAP; PDIA4, TBCB, PKD1, and DCXR; PDIA4, FAP, DCXR, and ALCAM; CEACAM5, AGR3, HEG1, and PRDX1; SERPINA1, PDIA4, PKD1, and DCXR; ADAM12, TNC, AGR3, and IL1RAP; PDIA4, PKD1, PRTN3, and PEPD; ADAM12 , PDIA4, CD55 and FAP; ADAM12, CEACAM5, DCXR and IL1RAP; SERPINA1, MEGF9, PRTN3 and IL1RAP; AREG, ADAM12, HEG1 and IL1RAP; AREG, MAMDC4, IL1RAP and PLXDC2; CEACAM5, ADAMTSL4, SLAMF8 and HEG1; ADAM12, AGR3, MAMDC4 and IL1RAP; FGA, CLEC3B, MAMDC4 and HEG1; PDIA4, ITIH3, PEPD and FAP; AREG, ADAM12, IL1RAP and PLXDC2;CEACAM5, ADAMTSL4, HEG1, and PRDX1; FGA, TBCB, MAMDC4, and HEG1; ADAM12, SLAMF8, DCXR, and IL1RAP; SERPINA1, PDIA4, CEACAM5, and HEG1; AREG, TBCB, PKD1, and DCXR; AREG, CEACAM5, HEG1, and IL1RAP; PDIA4, ITIH3, PKD1, and PEPD; SERPINA1, TBCB, SLAMF8, and PLXDC2; AREG, TNC, PKD1, and MAMDC4; SERPINA1, PDIA4, MAMDC4, and PLXDC2; ADAM12, DCXR, IL1RAP and ALCAM; FGA, SLAMF8, PEPD and HEG1; PDIA4, IGFBP2, DCXR and ALCAM; SERPINA1, SLAMF8, PEPD and DCXR; PDIA4, ADAMTSL4, PKD1 and DCXR; ADAM12, TNC, FAP and PRDX1; SERPINA1, CLEC3B, IL1RAP and PLXDC2; PDIA4, PRTN3, PEPD and FAP; CEACAM5, SLAMF8, HEG1 and DCXR; PDIA4, MCAM, DCXR and ALCAM; SERPINA1, CEACAM5, HEG1 and IL1RAP; SERPINA1, HEG1, IL1RAP and PLXDC2; AREG, PKD1, DCXR and IL1RAP; AREG, ADAM12, PDIA4 and CD55; ADAM12, MAMDC4, FAP and PRDX1; PDIA4, PEPD, DCXR and IL1RAP; PDIA4, IGFBP2, CD55 and MCAM; CEACAM5, FGA, TBCB and HEG1; CEACAM5, FGA, AGR3 and HEG1; CEACAM5, FGA, SLAMF8 and HEG1; PDIA4, CEACAM5, FGA and HEG1; CEACAM5, FGA, HEG1 and IL1RAP; CEACAM5, FGA, ADAMTSL4 and HEG1; AREG, FGA, AGR3 and HEG1; PDIA4, PKD1, SLAMF8 and DCXR; PDIA4, PKD1, MAMDC4 and DCXR; AREG, FGA, PKD1 and HEG1; AREG, FGA, MAMDC4 and HEG1; AREG, FGA, TBCB and HEG1; CEACAM5, FGA, HEG1 and DCXR; CEACAM5, FGA, MAMDC4 and HEG1; CEACAM5, FGA, HEG1 and PLXDC2;CEACAM5, FGA, HEG1 and NCS1; CEACAM5, FGA, ASPN and HEG1; PDIA4, CEACAM5, HEG1 and DCXR; PDIA4, CEACAM5, IL17RA and DCXR; CEACAM5, FGA, PRTN3 and HEG1; CEACAM5, FGA, IGFBP2 and HEG1; CEACAM5, TNC, AGR3 and HEG1; CEACAM5, FGA, HEG1 and CD34; PDIA4, TNC, PKD1 and DCXR; CEACAM5, FGA, CLEC3B and HEG1; PDIA4, PKD1, IL17RA and DCXR; CEACAM5, FGA, MEGF9, and HEG1; CEACAM5, FGA, ITIH3, and HEG1; CEACAM5, FGA, LRG1, and HEG1; AREG, FGA, HEG1, and MCAM; ADAM12, CEACAM5, HEG1, and PRDX1; PDIA4, CEACAM5, HEG1, and CD55; AREG, FGA, ASPN, and HEG1; AREG, ADAM12, PKD1, and IL1RAP; AREG, FGA, MEGF9, and HEG1; AREG, ADAM12, PKD1, and NCS1; CEACAM5, FGA, HEG1, and MCA M; PDIA4, SLAMF8, IL17RA and DCXR; PDIA4, PEPD, HEG1 and ALCAM; ADAM12, PDIA4, PEPD and DCXR; AREG, FGA, HEG1 and PLXDC2; PDIA4, TNC, TBCB and FAP; SERPINA1, ADAM12, NCS1 and PLXDC2; ADAM12, CEACAM5, FGA and NCS1; AREG, FGA, HEG1 and ALCAM; AREG, PDIA4, PKD1 and HEG1; AREG, PDIA4, PEPD and DCXR; AREG, PDIA4, FGA and HEG1; P DIA4, TNC, PKD1 and MAMDC4; PDIA4, CEACAM5, TNC and HEG1; AREG, ADAM12, FGA and PKD1; SERPINA1, MAMDC4, SLAMF8 and PLXDC2; AREG, ADAM12, ITIH3 and NCS1; AREG, FGA, HEG1 and NCS1; PDIA4, CEACAM5, AGR3 and HEG1; AREG, FGA, HEG1 and DCXR; SERPINA1, AREG, DCXR and PLXDC2; AREG, FGA, PKD1 and DCXR; AREG, FGA, ADAMTSL4 and HEG1;SERPINA1, SLAMF8, HEG1, and PLXDC2; PDIA4, FGA, PEPD, and FAP; PDIA4, CEACAM5, PEPD, and NCS1; PDIA4, CEACAM5, IL17RA, and CD55; ADAM12, PDIA4, DCXR, and IL1RAP; AREG, ADAM12, DCXR, and IL1RAP; PDIA4, PKD1, DCXR, and ALCAM; ADAM12, TNC, MAMDC4, and IL1RAP; AREG, ADAM12, FGA, and NCS1; AREG, FGA, PKD1, and IL1RAP; AREG, PDIA4, M CAM and DCXR; AREG, CEACAM5, AGR3 and HEG1; CEACAM5, TNC, SLAMF8 and HEG1; SERPINA1, TNC, IL1RAP and PLXDC2; PDIA4, TNC, PKD1 and PEPD; PDIA4, CEACAM5, MCAM and DCXR; SERPINA1, SLAMF8, IL1RAP and PLXDC2; SERPINA1, AREG, HEG1 and PLXDC2; CEACAM5, FGA, HEG1 and ALCAM; AREG, FGA, HEG1 and PRDX1; PDIA4, FGA, IL17RA and DCXR; PDIA4, TNC, MAMDC4, and FAP; PDIA4, CEACAM5, MAMDC4, and HEG1; ADAM12, CEACAM5, HEG1, and IL1RAP; ADAM12, PDIA4, PEPD, and FAP; PDIA4, CEACAM5, HEG1, and FAP; ADAM12, CEACAM5, PEPD, and IL1RAP; AREG, TNC, ITIH3, and NCS1; FGA, TBCB, PEPD, and HEG1; CEACAM5, FGA, IL17RA, and HEG1; ADAM12, FGA, SLAMF8, and HEG1; ADAM12, TNC, DCXR and IL1RAP; ADAM12, CEACAM5, TBCB and HEG1; PDIA4, TNC, IGFBP2 and PKD1; CEACAM5, FGA, HEG1 and FAP; AREG, FGA, PKD1 and NCS1; ADAM12, AGR3, HEG1 and IL1RAP; AREG, FGA, HEG1 and CD55; ADAM12, PDIA4, CD55 and DCXR; AREG, PDIA4, PEPD and HEG1; PDIA4, CEACAM5, PKD1 and PEPD; AREG, FGA, SLAMF8 and HEG1; PDIA4, PKD1, AGR3 and PEPD;SERPINA1, TNC, PKD1, and PLXDC2; PDIA4, PKD1, CD34, and DCXR; AREG, CEACAM5, ADAMTSL4, and HEG1; PDIA4, PEPD, HEG1, and IL1RAP; PDIA4, CEACAM5, PEPD, and DCXR; PDIA4, CEACAM5, TNC, and FAP; ADAM12, FGA, AGR3, and HEG1; PDIA4, CEACAM5, HEG1, and PRDX1; SERPINA1, SLAMF8, NCS1, and PLXDC2; AREG, ADAM12, HEG1, and CD55; SERPINA1, S LAMF8, HEG1, and DCXR; SERPINA1, AREG, NCS1, and PLXDC2; PDIA4, CEACAM5, FGA, and MEGF9; AREG, FGA, and IL17RA and HEG1; PDIA4, TBCB, PEPD, and HEG1; ADAM12, TNC, MAMDC4, and PLXDC2; PDIA4, TBCB, PKD1, and MAMDC4; SERPINA1, CEACAM5, PEPD, and IL1RAP; PDIA4, PEPD, FAP, and PRDX1; AREG, ADAM12, FAP, and IL1RAP; AREG, ADAM12, TBCB, and CD 55; PDIA4, TNC, MAMDC4 and NCS1; PDIA4, TNC, PKD1 and AGR3; ADAM12, TNC, FAP and IL1RAP; ADAM12, ITIH3, AGR3 and IL1RAP; SERPINA1, ADAM12, TNC and PLXDC2; AREG, AGR3, MAMDC4 and IL1RAP; SERPINA1, PDIA4, PKD1 and PLXDC2; PDIA4, IGFBP2, PEPD and FAP; PDIA4, FGA, PKD1 and MAMDC4; AREG, CEACAM5, IL17RA and HEG1; FGA, MAMDC 4. SLAMF8 and HEG1; PDIA4, IL17RA, MCAM and DCXR; PDIA4, ASPN, PKD1 and PEPD; PDIA4, TBCB, MCAM and DCXR; SERPINA1, CD34, IL1RAP and PLXDC2; ADAM12, FGA, TBCB and HEG1; SERPINA1, CEACAM5, HEG1 and PRDX1; AREG, ADAM12, IGFBP2 and CD55; PDIA4, PKD1, PEPD and HEG1; PDIA4, ITIH3, MCAM and DCXR; ADAM12, CEACAM5, FAP and IL1RAP;PDIA4, ITIH3, PKD1 and DCXR; SERPINA1, DCXR, IL1RAP and PLXDC2; CEACAM5, FGA, FAP and PRDX1; AREG, PKD1, PRTN3 and IL1RAP; SERPINA1, AREG, CD34 and DCXR; PDIA4, CEACAM5, MEGF9 and DCXR; PDIA4, PEPD, HEG1 and DCXR; AREG, PDIA4, NCS1 and DCXR; SERPINA1, ADAMTSL4, IL1RAP and PLXDC2; PDIA4, TNC, MAMDC4 and PLXDC2; SERPINA 1. TNC, MAMDC4, and PLXDC2; ADAM12, AGR3, FAP, and IL1RAP; FGA, IGFBP2, HEG1, and IL1RAP; PDIA4, TBCB, CD55, and FAP; CEACAM5, TBCB, SLAMF8, and HEG1; PDIA4, ITIH3, NCS1, and MCAM; SERPINA1, TBCB, IL1RAP, and PLXDC2; ADAM12, CEACAM5, TNC, and HEG1; AREG, ADAM12, CD55, and IL1RAP; PDIA4, MEGF9, PEPD, and FAP; PDIA4, FGA, MAMDC4, and PLX DC2; SERPINA1, PDIA4, DCXR and PLXDC2; SERPINA1, PDIA4, IL1RAP and PLXDC2; SERPINA1, ADAM12, DCXR and PLXDC2; SERPINA1, TNC, NCS1 and PLXDC2; AREG, MAMDC4, HEG1 and IL1RAP; ADAM12, CEACAM5, CD34 and PRDX1; CEACAM5, AGR3, HEG1 and IL1RAP; SERPINA1, CEACAM5, ADAMTSL4 and PEPD; PDIA4, ITIH3, PEPD and MCAM; SERPINA1, PDIA4, TBCB and PLXDC2; CEACAM5, FGA, SLAMF8 and MEGF9; PDIA4, PEPD, FAP and IL1RAP; SERPINA1, PDIA4, PEPD and FAP; SERPINA1, MEGF9, IL1RAP and PLXDC2; CEACAM5, TNC, FAP and PRDX1; AREG, ADAM12, PKD1 and AGR3; AREG, ADAM12, PKD1 and CD55; SERPINA1, FAP, PRDX1 and DCXR; PDIA4, TNC, MAMDC4 and MCAM; PDIA4, FGA, PKD1 and HEG1;CEACAM5, TNC, HEG1, and PRDX1; PDIA4, FGA, HEG1, and ALCAM; PDIA4, IGFBP2, PKD1, and CD55; PDIA4, FGA, MAMDC4, and HEG1; SERPINA1, ADAM12, CEACAM5, and CD55; AREG, TNC, PEPD, and HEG1; SERPINA1, SLAMF8, MEGF9, and DCXR; PDIA4, MAMDC4, DCXR, and ALCAM; SERPINA1, CLEC3B, SLAMF8, and DCXR; ADAM12, FGA, MAMDC4, and IL1RAP; TNC, AG R3, HEG1 and IL1RAP; AREG, ADAMTSL4, PEPD and HEG1; SERPINA1, PDIA4, IL17RA and PLXDC2; ADAM12, FGA, FAP and CD34; SERPINA1, PDIA4, TNC and PLXDC2; SERPINA1, FGA, HEG1 and PLXDC2; AREG, ASPN, PKD1 and DCXR; AREG, TBCB, CD55 and FAP; FGA, MAMDC4, HEG1 and IL1RAP; SERPINA1, CEACAM5, AGR3 and HEG1; AREG, FGA, HEG1 and FAP; A DAM12, AGR3, SLAMF8, and IL1RAP; PDIA4, ASPN, PEPD, and FAP; CEACAM5, MAMDC4, SLAMF8, and HEG1; AREG, ADAM12, CD55, and DCXR; AREG, PDIA4, DCXR, and IL1RAP; SERPINA1, PKD1, IL1RAP, and PLXDC2; FGA, TBCB, AGR3, and HEG1; AREG, CEACAM5, TBCB, and HEG1; AREG, FGA, PKD1, and PEPD; AREG, FGA, MAMDC4, and PLXDC2; TNC, AGR3, MEGF9, and IL1 RAP; SERPINA1, SLAMF8, CD55 and PLXDC2; AREG, ADAM12, DCXR and ALCAM; SERPINA1, CEACAM5, HEG1 and PLXDC2; SERPINA1, PDIA4, HEG1 and PLXDC2; AREG, TNC, AGR3 and FAP; PDIA4, MAMDC4, CD34 and DCXR; SERPINA1, AREG, MAMDC4 and PLXDC2; PDIA4, CD55, DCXR and ALCAM; AREG, ADAM12, FGA and CD34; CEACAM5, TNC, HEG1 and IL1RAP;ADAM12, PDIA4, FAP and PRDX1; PDIA4, TBCB, MAMDC4 and CD55; PDIA4, TNC, FAP and MCAM; AREG, FGA, PKD1 and MAMDC4; PDIA4, PKD1, PRTN3 and DCXR; SERPINA1, CD55, IL1RAP and PLXDC2; SERPINA1, ADAM12, PKD1 and IL1RAP; FGA, IGFBP2, PKD1 and IL1RAP; AREG, PDIA4, FGA and PKD1; PDIA4, MAMDC4, PEPD and HEG1; SERPINA1, PDIA4, FGA and HEG1; SERPINA1, CEACAM5, TNC and HEG1; SERPINA1, TNC, AGR3 and IL1RAP; PDIA4, TNC, HEG1 and DCXR; PDIA4, CEACAM5, TBCB and HEG1; PDIA4, CEACAM5, CD55 and ALCAM; PDIA4, ADAMTSL4, PKD1 and PEPD; AREG, AGR3, CD34 and IL1RAP; AREG, PDIA4, CD34 and DCXR; ADAM12, ITIH3, CLEC3B and IL1RAP; TNC, LRG1, AGR3 and IL1RAP; PDIA4, CEACAM5, TBCB and HEG1; PDIA4, CEACAM5, CD55 and ALCAM; PDIA4, ADAMTSL4, PKD1 and PEPD; AREG, AGR3, CD34 and IL1RAP; AREG, PDIA4, CD34 and DCXR; ADAM12, ITIH3, CLEC3B and IL1RAP; TNC, LRG1, AGR3 and IL1RAP; ACAM5, CD34, and DCXR; PDIA4, TNC, ASPN, and PEPD; PDIA4, FGA, PKD1, and PEPD; AREG, ADAMTSL4, PKD1, and IL1RAP; PDIA4, TNC, ITIH3, and MCAM; SERPINA1, ADAM12, AGR3, and IL1RAP; PDIA4, CEACAM5, CD55, and DCXR; ADAM12, PDIA4, PKD1, and AGR3; AREG, CEACAM5, TNC, and HEG1; ADAM12, CEACAM5, FGA, and MEGF9; SERPINA1, PDIA4, PKD1, and PEPD ;CEACAM5, TNC, MEGF9 and IL1RAP;PDIA4, SLAMF8, DCXR and ALCAM;PDIA4, IL17RA, FAP and DCXR;PDIA4, FGA, DCXR and ALCAM;PDIA4, TBCB, MAMDC4 and PLXDC2;PDIA4, TBCB, FAP and DCXR;TNC, TBCB, MAMDC4 and PLXDC2;ADAM12, CD55, FAP and PRDX1;PDIA4, TNC, FAP and PLXDC2;PDIA4, CEACAM5, HEG1 and PLXDC2;AREG, PDIA4, PEPD and FAP;PDIA4, SLAMF8, PEPD, and DCXR; TNC, MAMDC4, IL1RAP, and PLXDC2; PDIA4, ITIH3, PKD1, and MAMDC4; CEACAM5, ITIH3, TBCB, and HEG1; PDIA4, PKD1, MAMDC4, and CD55; SERPINA1, ADAM12, CEACAM5, and NCS1; AREG, ADAM12, CEACAM5, and HEG1; ADAM12, PDIA4, PEPD, and IL1RAP; PDIA4, TNC, IL17RA, and DCXR; AREG, CEACAM5, HEG1, and PRDX1; ADAM12 , FGA, AGR3 and CD34; PDIA4, PKD1, CD55 and DCXR; AREG, LRG1, IL1RAP and PLXDC2; AREG, TNC, IL1RAP and PLXDC2; AREG, ADAM12, PEPD and NCS1; PDIA4, CEACAM5, PEPD and FAP; AREG, ADAM12, FAP and NCS1; AREG, TBCB, HEG1 and CD55; CEACAM5, ITIH3, ADAMTSL4 and HEG1; SERPINA1, ADAM12, NCS1 and IL1RAP; SERPINA1, AREG, CEACAM5 and HEG 1; SERPINA1, TNC, TBCB and PLXDC2; SERPINA1, AREG, CD55 and DCXR; SERPINA1, FAP, PRDX1 and IL1RAP; SERPINA1, PDIA4, CD34 and PLXDC2; SERPINA1, SLAMF8, IL17RA and PLXDC2; PDIA4, TNC, AGR3 and FAP; PDIA4, CEACAM5, TNC and MCAM; PDIA4, CD34, DCXR and ALCAM; PDIA4, AGR3, MEGF9 and IL1RAP; PDIA4, CEACAM5, ASPN and HEG1; ADAM 12. PDIA4, CD34 and DCXR; SERPINA1, CEACAM5, CLEC3B and HEG1; PDIA4, TNC, PKD1 and MCAM; PDIA4, PEPD, IL17RA and FAP; PDIA4, PEPD, FAP and MCAM; AREG, IGFBP2, PKD1 and IL1RAP; AREG, PDIA4, CD55 and ALCAM; AREG, TNC, MAMDC4 and HEG1; SERPINA1, AREG, PKD1 and IL1RAP; PDIA4, IGFBP2, PKD1 and PEPD; SERPINA1, AREG, PDIA4 and PKD1;ADAM12, FGA, HEG1, and IL1RAP; PDIA4, IGFBP2, MCAM, and DCXR; ADAM12, TBCB, MAMDC4, and PLXDC2; SERPINA1, AREG, IL17RA, and PLXDC2; FGA, SLAMF8, HEG1, and IL1RAP; ADAM12, LRG1, AGR3, and IL1RAP; AREG, PDIA4, FAP, and DCXR; CEACAM5, HEG1, FAP, and PRDX1; SERPINA1, CEACAM5, TNC, and PLXDC2; AREG, PDIA4, HEG1, and CD55; PDIA4, AGR3 , PEPD and FAP; ADAM12, ITIH3, FAP and PRDX1; ADAM12, MAMDC4, IL1RAP and PLXDC2; AREG, PDIA4, TBCB and NCS1; ADAM12, FGA, ITIH3 and NCS1; FGA, AGR3, MEGF9 and IL1RAP; SERPINA1, ADAM12, PKD1 and PLXDC2; PDIA4, PEPD, IL17RA and DCXR; SERPINA1, AREG, PKD1 and PLXDC2; CEACAM5, ASPN, AGR3 and HEG1; PDIA4, MAMDC4, CD55 and ALCAM ;AREG, ADAM12, NCS1 and IL1RAP;SERPINA1, AREG, MEGF9 and IL1RAP;PDIA4, AGR3, PEPD and HEG1;PDIA4, TNC, FAP and IL1RAP;ADAM12, ITIH3, PKD1 and PRDX1;ADAM12, ITIH3, NCS1 and IL1RAP;ADAM12, ITIH3, PKD1 and IL1RAP;SERPINA1, CEACAM5, MEGF9 and IL1RAP;PDIA4, FGA, TBCB and HEG1;ADAM12, FGA, FAP and IL1RAP;AREG, TNC, AGR3 and IL1RAP; SERPINA1, FGA, HEG1 and IL1RAP; TNC, AGR3, FAP and IL1RAP; ADAM12, SLAMF8, DCXR and ALCAM; PDIA4, ITIH3, PEPD and HEG1; AREG, TNC, FAP and IL1RAP; SERPINA1, SLAMF8, IL17RA and DCXR; ADAM12, ITIH3, CLEC3B and NCS1; SERPINA1, CLEC3B, FAP and PRDX1; PDIA4, TBCB, MAMDC4 and MCAM; PDIA4, IGFBP2, CD55 and ALCAM;SERPINA1, TNC, IL17RA and PLXDC2; ADAM12, CEACAM5, CLEC3B and IL1RAP; PDIA4, TNC, IL17RA and MCAM; AREG, PDIA4, CEACAM5 and CD55; ADAM12, TBCB, MAMDC4 and CD55; AREG, CEACAM5, FGA and MEGF9; SERPINA1, AREG, ADAM12 and PLXDC2; SERPINA1, PKD1, DCXR and IL1RAP; SERPINA1, MAMDC4, IL17RA and PLXDC2; PDIA4, TBCB, PKD1 and PEPD; FGA, AGR3, HEG1, and IL1RAP; ADAM12, CEACAM5, TNC, and NCS1; SERPINA1, CEACAM5, SLAMF8, and DCXR; PDIA4, TNC, PKD1, and PLXDC2; AREG, TNC, AGR3, and MEGF9; PDIA4, TNC, ASPN, and MCAM; ADAM12, CEACAM5, CD34, and IL1RAP; ADAM12, TNC, AGR3, and FAP; PDIA4, TNC, FAP, and DCXR; AREG, ADAM12, AGR3, and NCS1; ADAM12, FGA, AGR3, and NCS1 ;CEACAM5, PKD1, SLAMF8 and DCXR;PDIA4, PEPD, FAP and CD34;SERPINA1, SLAMF8, PEPD and PLXDC2;AREG, ADAM12, MAMDC4 and NCS1;PDIA4, IL17RA, CD55 and ALCAM;PDIA4, PEPD, MCAM and DCXR;PDIA4, FGA, HEG1 and IL1RAP;SERPINA1, CEACAM5, PKD1 and DCXR;ADAM12, FGA, PEPD and HEG1;PDIA4, PKD1, PEPD and FAP;PDIA4, CEACAM5, HE G1 and MCAM; SERPINA1, PKD1, DCXR and PLXDC2; PDIA4, PKD1, MEGF9 and DCXR; AREG, FGA, CLEC3B and HEG1; SERPINA1, AGR3, IL1RAP and PLXDC2; ADAM12, PDIA4, FGA and PEPD; AREG, PDIA4, CD55 and PLXDC2; SERPINA1, FGA, IL1RAP and PLXDC2; PDIA4, PKD1, PEPD and ALCAM; SERPINA1, FGA, CLEC3B and HEG1; PDIA4, ADAMTSL4, DCXR and ALCAM;TNC, IGFBP2, PKD1, and IL1RAP; PDIA4, TNC, PKD1, and FAP; SERPINA1, PDIA4, PEPD, and HEG1; PDIA4, CEACAM5, MEGF9, and NCS1; SERPINA1, SLAMF8, DCXR, and ALCAM; CEACAM5, SLAMF8, HEG1, and PRDX1; ADAM12, PDIA4, MAMDC4, and PLXDC2; AREG, ADAM12, MCAM, and DCXR; CEACAM5, TNC, PEPD, and FAP; ADAM12, TNC, IGFBP2, and NCS1; CEACAM5, F GA, CLEC3B and IL1RAP; CEACAM5, FGA, MEGF9 and PRDX1; SERPINA1, CEACAM5, TBCB and PLXDC2; AREG, FGA, ITIH3 and HEG1; PDIA4, TNC, CD55 and FAP; SERPINA1, AGR3, SLAMF8 and HEG1; FGA, ASPN, AGR3 and HEG1; PDIA4, FGA, AGR3 and HEG1; ADAM12, PKD1, SLAMF8 and DCXR; AREG, TNC, MAMDC4 and CD55; SERPINA1, CEACAM5, PRDX1 and DCXR; PDIA4, MAMDC4, CD55 and DCXR; PDIA4, CEACAM5, TBCB and FAP; ADAM12, PDIA4, CEACAM5 and DCXR; SERPINA1, CLEC3B, AGR3 and IL1RAP; CEACAM5, TBCB, ADAMTSL4 and HEG1; SERPINA1, MAMDC4, HEG1 and PLXDC2; PDIA4, PKD1, FAP and DCXR; PDIA4, CD34, MCAM and DCXR; AREG, PKD1, MAMDC4 and DCXR; ADAM12, PDIA4, PEPD and HEG1; AREG, A DAM12, AGR3 and IL1RAP; PDIA4, FGA, MCAM and DCXR; AREG, CEACAM5, PEPD and HEG1; ADAM12, CLEC3B, TBCB and CD34; SERPINA1, PDIA4, DCXR and ALCAM; AREG, FGA, PRTN3 and HEG1; SERPINA1, TNC, FAP and PLXDC2; CEACAM5, TNC, PEPD and HEG1; AREG, ADAM12, NCS1 and PLXDC2; TNC, ITIH3, MAMDC4 and PLXDC2; PDIA4, ITIH3, PKD1 and AGR3;PDIA4, PKD1, MAMDC4, and PRDX1; CEACAM5, TNC, HEG1, and FAP; ADAM12, PDIA4, CD55, and ALCAM; SERPINA1, PDIA4, CLEC3B, and IL17RA; FGA, SLAMF8, HEG1, and DCXR; SERPINA1, FGA, PEPD, and HEG1; ADAM12, CEACAM5, ITIH3, and IL1RAP; TNC, IGFBP2, MCAM, and IL1RAP; CEACAM5, TNC, MAMDC4, and CD55; ADAM12, CEACAM5, HEG1, and FAP; AREG, PD IA4, PKD1 and IL1RAP; ADAM12, PDIA4, PKD1 and PEPD; FGA, CLEC3B, HEG1 and IL1RAP; CEACAM5, TNC, AGR3 and FAP; ADAM12, CEACAM5, CLEC3B and HEG1; AREG, PDIA4, TNC and FAP; ADAM12, CEACAM5, CD34 and DCXR; PDIA4, CEACAM5, HEG1 and IL1RAP; PDIA4, MAMDC4, MCAM and DCXR; ADAM12, CEACAM5, IL1RAP and PLXDC2; ADAM12, PEPD, DCXR and IL1RAP; AREG, PDIA4, FGA, and NCS1; AREG, FGA, ASPN, and PKD1; AREG, AGR3, MEGF9, and IL1RAP; PDIA4, TBCB, DCXR, and ALCAM; PDIA4, PKD1, PRDX1, and DCXR; AREG, PKD1, CD55, and DCXR; SERPINA1, PRTN3, IL1RAP, and PLXDC2; SERPINA1, FGA, AGR3, and HEG1; ADAM12, ITIH3, PEPD, and IL1RAP; ADAM12, CEACAM5, TBCB, and CD34; PDIA4, FGA, and IGF BP2 and MCAM; PDIA4, IGFBP2, PKD1 and PRDX1; SERPINA1, AREG, ADAM12 and NCS1; SERPINA1, AREG, PDIA4 and CD55; ADAM12, TNC, NCS1 and PLXDC2; PDIA4, CEACAM5, HEG1 and NCS1; PDIA4, PKD1, PEPD and MCAM; SERPINA1, PDIA4, CEACAM5 and IL17RA; PDIA4, TBCB, MAMDC4 and HEG1; PDIA4, MAMDC4, HEG1 and CD55; FGA, TBCB, SLAMF8 and HEG1;SERPINA1, PDIA4, SLAMF8, and PLXDC2; CEACAM5, FGA, IGFBP2, and PRDX1; ADAM12, AGR3, CD34, and IL1RAP; AREG, PDIA4, TNC, and HEG1; PDIA4, CEACAM5, ADAMTSL4, and HEG1; SERPINA1, CEACAM5, CD55, and DCXR; PDIA4, CEACAM5, CD34, and ALCAM; PDIA4, PEPD, HEG1, and MCAM; SERPINA1, AREG, CD55, and PLXDC2; AREG, ADAMTSL4, PKD1, and PEP D; SERPINA1, AREG, ADAM12 and CD55; ADAM12, CEACAM5, HEG1 and CD55; ADAM12, TNC, PKD1 and MAMDC4; PDIA4, ADAMTSL4, PEPD and HEG1; ADAM12, CEACAM5, SLAMF8 and HEG1; CEACAM5, HEG1, PRDX1 and DCXR; SERPINA1, CEACAM5, TNC and PKD1; AREG, ADAM12, LRG1 and NCS1; AREG, SLAMF8, PEPD and DCXR; SERPINA1, CEACAM5, IL17RA and P RDX1; AREG, ADAM12, FAP, and PRDX1; ADAM12, ITIH3, CLEC3B, and CD55; SERPINA1, TNC, AGR3, and MEGF9; ADAM12, FGA, ASPN, and HEG1; AREG, ADAM12, AGR3, and HEG1; CEACAM5, FGA, PKD1, and HEG1; AREG, PKD1, MCAM, and DCXR; AREG, TNC, MCAM, and IL1RAP; ADAM12, TNC, IL1RAP, and PLXDC2; PDIA4, FGA, FAP, and PRDX1; ADAM12, TBCB, FAP, and IL1R AP; PDIA4, CEACAM5, AGR3 and MEGF9; PDIA4, PEPD, FAP and NCS1; PDIA4, AGR3, MAMDC4 and HEG1; ADAM12, CLEC3B, DCXR and IL1RAP; SERPINA1, CEACAM5, HEG1 and CD34; ADAM12, CEACAM5, HEG1 and PLXDC2; SERPINA1, MAMDC4, DCXR and PLXDC2; AREG, ITIH3, PKD1 and DCXR; AREG, PDIA4, CD55 and DCXR; ADAM12, CEACAM5, ITIH3 and HEG1;PDIA4, CEACAM5, PKD1 and HEG1; AREG, TNC, PKD1 and IL1RAP; PDIA4, MAMDC4, FAP and PRDX1; CEACAM5, TNC, TBCB and HEG1; SERPINA1, AREG, FGA and PKD1; CEACAM5, TNC, MAMDC4 and HEG1; ADAM12, FGA, PKD1 and MAMDC4; PDIA4, SLAMF8, PEPD and HEG1; ADAM12, FGA, FAP and NCS1; SERPINA1, AREG, PRDX1 and PLXDC2; PDIA4, CEACAM5, MAMD C4 and DCXR; PDIA4, TNC, PKD1 and HEG1; ADAM12, PDIA4, MAMDC4 and CD34; CEACAM5, MEGF9, PRTN3 and IL1RAP; SERPINA1, TBCB, MAMDC4 and PLXDC2; PDIA4, IGFBP2, PEPD and HEG1; SERPINA1, CEACAM5, CLEC3B and IL17RA; AREG, CEACAM5, HEG1 and DCXR; CEACAM5, TBCB, AGR3 and HEG1; AREG, TNC, TBCB and FAP; PDIA4, FAP, PRDX1 and DCXR; PD IA4, CEACAM5, SLAMF8 and HEG1; SERPINA1, IL17RA, IL1RAP and PLXDC2; PDIA4, CEACAM5, PEPD and MCAM; PDIA4, MAMDC4, CD55 and FAP; AREG, ADAM12, SLAMF8 and DCXR; AREG, PDIA4, TBCB and CD55; SERPINA1, ADAM12, CEACAM5 and HEG1; CEACAM5, ADAMTSL4, MAMDC4 and HEG1; PDIA4, PKD1, MCAM and DCXR; AREG, FGA, MAMDC4 and NCS1; ADA M12, ITIH3, NCS1, and PLXDC2; AREG, TNC, IGFBP2, and NCS1; AREG, ADAM12, HEG1, and NCS1; PDIA4, TNC, PEPD, and HEG1; PDIA4, CEACAM5, MEGF9, and HEG1; AREG, PDIA4, IL17RA, and NCS1; SERPINA1, FGA, ADAMTSL4, and HEG1; AREG, PDIA4, CD55, and MCAM; ADAM12, PDIA4, CEACAM5, and PEPD; PDIA4, FGA, AGR3, and FAP; TNC, MAMDC4, SLAMF8, and DCXR;ADAM12, CEACAM5, TBCB, and CD55; SERPINA1, ADAM12, TNC, and NCS1; SERPINA1, ADAM12, DCXR, and IL1RAP; AREG, SLAMF8, MCAM, and DCXR; PDIA4, ADAMTSL4, PKD1, and MAMDC4; ADAM12, CEACAM5, HEG1, and CD34; ADAM12, ITIH3, DCXR, and IL1RAP; FGA, CLEC3B, TBCB, and HEG1; ADAM12, CEACAM5, TBCB, and NCS1; PKD1, MAMDC4, SLAMF8, and DCXR ;PDIA4, MCAM, PRDX1 and DCXR;AREG, PDIA4, ADAMTSL4 and PKD1;AREG, PDIA4, CD55 and IL1RAP;ADAM12, MAMDC4, FAP and IL1RAP;SERPINA1, PDIA4, AGR3 and PLXDC2;ADAM12, TBCB, CD55 and FAP;SERPINA1, IL17RA, DCXR and PLXDC2;SERPINA1, TBCB, PEPD and PLXDC2;AREG, ADAM12, TBCB and DCXR;SERPINA1, AREG, DCXR and IL1RAP;S ERPINA1, CEACAM5, SLAMF8 and PLXDC2; AREG, ADAM12, IGFBP2 and NCS1; ADAM12, IGFBP2, AGR3 and IL1RAP; ADAM12, FGA, CLEC3B and HEG1; PDIA4, TNC, TBCB and MCAM; AREG, FGA, PKD1 and AGR3; SERPINA1, CEACAM5, ADAMTSL4 and HEG1; IGFBP2, PKD1, SLAMF8 and DCXR; SERPINA1, ADAM12, SLAMF8 and DCXR; PDIA4, TNC, MEGF9 and PEPD; AREG, TNC, FGA and HEG1; PDIA4, SLAMF8, HEG1 and DCXR; PDIA4, TBCB, CD55 and ALCAM; AREG, PDIA4, ASPN and PKD1; PDIA4, AGR3, CD55 and FAP; PDIA4, PEPD, CD55 and FAP; ADAM12, CD34, DCXR and IL1RAP; AREG, PDIA4, CEACAM5 and DCXR; ADAM12, CEACAM5, MEGF9 and IL1RAP; CEACAM5, ITIH3, SLAMF8 and HEG1; AREG, PDIA4, PKD1 and PEPD;PDIA4, CLEC3B, DCXR, and ALCAM; SERPINA1, CEACAM5, NCS1, and PLXDC2; FGA, IGFBP2, PKD1, and HEG1; AREG, SLAMF8, NCS1, and DCXR; SERPINA1, CEACAM5, IL17RA, and DCXR; SERPINA1, ADAM12, CEACAM5, and IL1RAP; AREG, PDIA4, AGR3, and CD55; AREG, CEACAM5, MAMDC4, and HEG1; PDIA4, IGFBP2, CLEC3B, and PKD1; ADAM12, FGA, IGFBP2, and NCS 1; SERPINA1, ADAM12, MAMDC4, and PLXDC2; AREG, ADAM12, CEACAM5, and NCS1; PDIA4, ITIH3, DCXR, and ALCAM; SERPINA1, SLAMF8, MCAM, and DCXR; AREG, ADAM12, PDIA4, and NCS1; AREG, FGA, HEG1, and CD34; SERPINA1, AREG, ADAM12, and PKD1; ADAM12, PDIA4, CEACAM5, and HEG1; ADAM12, CEACAM5, SLAMF8, and NCS1; SERPINA1, FGA, HEG1, and PRD X1; PDIA4, TNC, PEPD and MCAM; ADAM12, TNC, FAP and NCS1; AREG, ADAM12, NCS1 and ALCAM; ADAM12, FGA, ITIH3 and HEG1; AREG, PDIA4, TNC and PKD1; AREG, SLAMF8, CD55 and DCXR; SERPINA1, PDIA4, PEPD and IL17RA; ADAM12, CEACAM5, FGA and FAP; AREG, TNC, HEG1 and NCS1; SERPINA1, CEACAM5, DCXR and PLXDC2; CEACAM5, TNC, ITIH3 and HE G1; PDIA4, TNC, FGA and MCAM; AREG, PDIA4, PKD1 and CD55; AREG, CD34, MCAM and DCXR; SERPINA1, PKD1, PRTN3 and DCXR; AREG, PKD1, MAMDC4 and PRDX1; AREG, PDIA4, CD55 and FAP; PDIA4, ASPN, PKD1 and DCXR; AREG, CEACAM5, HEG1 and CD55; SERPINA1, TBCB, CD55 and PLXDC2; AREG, ADAM12, ASPN and CD55; AREG, ADAMTSL4, PEPD and IL1RAP;TNC, ITIH3, FAP, and PRDX1; PDIA4, FGA, AGR3, and MEGF9; AREG, PDIA4, ITIH3, and NCS1; PDIA4, HEG1, MCAM, and DCXR; AREG, IGFBP2, ADAMTSL4, and PKD1; SERPINA1, PDIA4, ASPN, and PLXDC2; ADAM12, TNC, ITIH3, and NCS1; AREG, LRG1, PKD1, and DCXR; TNC, FGA, MAMDC4, and HEG1; SERPINA1, MAMDC4, FAP, and PRDX1; PDIA4, CEACAM5, HEG1, and ALCA M; PDIA4, TNC, TBCB and PKD1; PDIA4, PKD1, DCXR and PLXDC2; AREG, TNC, PKD1 and HEG1; PDIA4, ASPN, PEPD and HEG1; AREG, ADAM12, CD55 and NCS1; AREG, TNC, PKD1 and PEPD; SERPINA1, TNC, AGR3 and PLXDC2; CEACAM5, FGA, AGR3 and MEGF9; AREG, FGA, MCAM and DCXR; AREG, SLAMF8, HEG1 and DCXR; SERPINA1, CEACAM5, PEPD and PLXDC2; ADAM 12. PDIA4, MCAM, and DCXR; PDIA4, PKD1, MAMDC4, and PLXDC2; PDIA4, MAMDC4, IL1RAP, and PLXDC2; CEACAM5, TBCB, MAMDC4, and CD55; SLAMF8, MCAM, DCXR, and IL1RAP; SERPINA1, SLAMF8, MEGF9, and IL1RAP; AREG, TNC, MAMDC4, and MCAM; CEACAM5, LRG1, MEGF9, and IL1RAP; ADAM12, ITIH3, CD34, and NCS1; SERPINA1, CEACAM5, PEPD, and HEG1; PD IA4, FGA, ITIH3 and PKD1; PDIA4, MCAM, DCXR and IL1RAP; ADAM12, TNC, TBCB and FAP; AREG, TBCB, ADAMTSL4 and PKD1; AREG, ADAM12, TBCB and NCS1; ADAM12, PDIA4, FGA and HEG1; SERPINA1, CLEC3B, CD34 and IL1RAP; SERPINA1, TNC, HEG1 and PLXDC2; SERPINA1, AREG, MEGF9 and CD55; PDIA4, FGA, ASPN and HEG1; PDIA4, PEPD, CD34 and DCXR;AREG, AGR3, HEG1 and IL1RAP; PDIA4, TNC, ITIH3 and FAP; SERPINA1, AREG, TBCB and PLXDC2; SERPINA1, CLEC3B, IL17RA and IL1RAP; PDIA4, PKD1, CD55 and ALCAM; AREG, FGA, MEGF9 and IL1RAP; SERPINA1, TNC, FAP and PRDX1; PDIA4, MAMDC4, HEG1 and MCAM; ADAM12, FGA, PEPD and FAP; CEACAM5, IGFBP2, SLAMF8 and HEG1; ADAM12, A GR3, IL1RAP and PLXDC2; SERPINA1, ADAM12, FGA and NCS1; PDIA4, CD55, DCXR and IL1RAP; SERPINA1, TNC, CLEC3B and IL17RA; PDIA4, PKD1, PEPD and NCS1; CEACAM5, FGA, MEGF9 and DCXR; PDIA4, MEGF9, DCXR and ALCAM; PDIA4, MAMDC4, MCAM and PRDX1; PDIA4, TBCB, FAP and PRDX1; FGA, MAMDC4, HEG1 and MCAM; PDIA4, PKD1, MAMDC4 and PEPD; AREG, IGFBP2, TBCB and CD55; SERPINA1, PDIA4, CEACAM5 and PEPD; PDIA4, HEG1, DCXR and ALCAM; PDIA4, TNC, HEG1 and MCAM; PDIA4, IGFBP2, TBCB and MCAM; PDIA4, TNC, HEG1 and FAP; SERPINA1, AREG, AGR3 and IL1RAP; SERPINA1, PDIA4, MAMDC4 and CD55; AREG, ADAM12, AGR3 and CD55; ADAM12, FGA, HEG1 and PRDX1; PDIA4, CE ACAM5, TNC and PKD1; PDIA4, IL17RA, CD55 and DCXR; AREG, TNC, MEGF9 and CD55; AREG, ADAMTSL4, PEPD and NCS1; FGA, IGFBP2, PKD1 and DCXR; AREG, TNC, MEGF9 and NCS1; PDIA4, MAMDC4, HEG1 and DCXR; PDIA4, MAMDC4, IL17RA and DCXR; SERPINA1, FGA, CLEC3B and IL17RA; ADAM12, TNC, MAMDC4 and FAP; AREG, ADAM12, SLAMF8 and NCS1;SERPINA1, MAMDC4, PLXDC2 and ALCAM; PDIA4, PKD1, SLAMF8 and PEPD; PDIA4, TNC, FAP and PRDX1; PDIA4, TNC, MAMDC4 and DCXR; PDIA4, PKD1, HEG1 and DCXR; ADAM12, TNC, ITIH3 and PKD1; SERPINA1, SLAMF8, CD55 and DCXR; CEACAM5, TNC, ADAMTSL4 and HEG1; CEACAM5, ADAMTSL4, PEPD and HEG1; PDIA4, ASPN, ADAMTSL4 and PEPD; AREG, FGA, PKD1, and MEGF9; PDIA4, MAMDC4, FAP, and PLXDC2; SERPINA1, ADAM12, TBCB, and PLXDC2; AREG, FGA, LRG1, and HEG1; SERPINA1, ADAM12, CD34, and PLXDC2; PDIA4, ASPN, PKD1, and AGR3; SERPINA1, CEACAM5, TNC, and MEGF9; PDIA4, TBCB, FAP, and IL1RAP; FGA, IGFBP2, PKD1, and PEPD; SERPINA1, AREG, IL17RA, and CD55; PDIA4, TNC, DCXR, and A LCAM; PDIA4, CEACAM5, HEG1, and CD34; TNC, AGR3, MAMDC4, and FAP; PDIA4, TBCB, HEG1, and DCXR; PDIA4, TNC, PEPD, and PLXDC2; PDIA4, PKD1, PEPD, and IL1RAP; PDIA4, CEACAM5, TNC, and DCXR; AREG, ADAM12, TNC, and PKD1; PDIA4, ASPN, PEPD, and CD55; AREG, IGFBP2, PRTN3, and CD55; SERPINA1, AGR3, MEGF9, and IL1RAP; ADAM12, FGA, NCS1, and I L1RAP; FGA, MAMDC4, SLAMF8 and PLXDC2; SERPINA1, PDIA4, TBCB and CD55; AREG, PDIA4, CEACAM5 and PKD1; PDIA4, ITIH3, PKD1 and NCS1; SERPINA1, CEACAM5, CD55 and PLXDC2; SERPINA1, ADAM12, CEACAM5 and PEPD; AREG, FGA, IGFBP2 and NCS1; PDIA4, CEACAM5, TNC and MEGF9; AREG, TNC, AGR3 and NCS1; CEACAM5, ASPN, TBCB and HEG1;ADAM12, TNC, MAMDC4 and NCS1; PDIA4, PKD1, AGR3 and MAMDC4; or AREG, ADAM12, PDIA4 and DCXR (i.e., 886 4-marker combinations in Table 6).

[0030] Preferably, the four markers combination is: CEACAM5, FGA, PEPD and HEG1; AREG, CEACAM5, FGA and HEG1; ADAM12, CEACAM5, FGA and HEG1; PDIA4, CEACAM5, PEPD, HEG1; CEACAM5, FGA, HEG1 and PRDX1; AREG, PDIA4, DCXR and ALCAM; SERPINA1, CEACAM5, FGA and HEG1; AREG, FGA, HEG1 and IL1RAP; AREG, FGA, PEPD and HEG1; ADAM12, PDIA4, DCXR and ALCAM; PDIA4, PKD1, DCXR, and IL1RAP; SERPINA1, ADAM12, FAP, and PRDX1; PDIA4, TNC, PEPD, and FAP; SERPINA1, PKD1, SLAMF8, and DCXR; PDIA4, PKD1, PEPD, and DCXR; AREG, PDIA4, PKD1, and DCXR; PDIA4, CEACAM5, PKD1, and DCXR; PDIA4, PEPD, FAP, and DCXR; SERPINA1, AREG, IL1RAP, and PLXDC2; PDIA4, TBCB, PEPD, and FAP; AREG, PDIA4, CEACAM5 and HEG1; AREG, ADAM12, FGA and HEG1; SERPINA1, CEACAM5, IL1RAP and PLXDC2; PDIA4, FGA, PKD1 and DCXR; PDIA4, CEACAM5, DCXR and ALCAM; ADAM12, FGA, MAMDC4 and HEG1; PDIA4, FGA, IGFBP2 and PKD1; ADAM12, LRG1, FAP and PRDX1; CEACAM5, TNC, FGA and HEG1; ADAM12, FGA, AGR3 and IL1RAP; SERPINA1, MAMDC4, IL1RAP and PLXDC2; PD IA4, TNC, MCAM and DCXR; SERPINA1, ADAM12, IL1RAP and PLXDC2; ADAM12, CEACAM5, FAP and PRDX1; AREG, ADAM12, PKD1 and DCXR; AREG, PKD1, SLAMF8 and DCXR; TNC, AGR3, MAMDC4 and IL1RAP; ADAM12, TBCB, FAP and PRDX1; PDIA4, CLEC3B, PKD1 and DCXR; PDIA4, FGA, PEPD and HEG1; PDIA4, PEPD, HEG1 and FAP; ADAM12, FGA, FAP and PRDX1;ADAM12, PDIA4, PKD1, and DCXR; PDIA4, SLAMF8, MCAM, and DCXR; PDIA4, DCXR, IL1RAP, and ALCAM; ADAM12, PEPD, FAP, and PRDX1; SERPINA1, AREG, FGA, and HEG1; PDIA4, TNC, IGFBP2, and MCAM; SERPINA1, AREG, PKD1, and DCXR; AREG, TNC, MAMDC4, and NCS1; ADAM12, FAP, PRDX1, and DCXR; AREG, ADAM12, TNC, and NCS1; PDIA4, IGFBP2, PKD1, and DC XR; PDIA4, IL17RA, DCXR and ALCAM; ADAM12, CLEC3B, AGR3 and IL1RAP; CEACAM5, AGR3, SLAMF8 and HEG1; SERPINA1, TNC, DCXR and PLXDC2; FGA, AGR3, SLAMF8 and HEG1; PDIA4, CEACAM5, MEGF9 and PEPD; PDIA4, TNC, MAMDC4 and CD55; CEACAM5, SLAMF8, PEPD and HEG1; SERPINA1, SLAMF8, DCXR and PLXDC2; SERPINA1, PEPD, IL1RAP and P LXDC2; SERPINA1, CEACAM5, CLEC3B, and PRDX1; PDIA4, TNC, ITIH3, and PKD1; ADAM12, FGA, SLAMF8, and NCS1; TNC, CLEC3B, AGR3, and IL1RAP; PDIA4, TBCB, PKD1, and DCXR; PDIA4, FAP, DCXR, and ALCAM; CEACAM5, AGR3, HEG1, and PRDX1; SERPINA1, PDIA4, PKD1, and DCXR; ADAM12, TNC, AGR3, and IL1RAP; PDIA4, PKD1, PRTN3, and PEPD; ADAM12 , PDIA4, CD55 and FAP; ADAM12, CEACAM5, DCXR and IL1RAP; SERPINA1, MEGF9, PRTN3 and IL1RAP; AREG, ADAM12, HEG1 and IL1RAP; AREG, MAMDC4, IL1RAP and PLXDC2; CEACAM5, ADAMTSL4, SLAMF8 and HEG1; ADAM12, AGR3, MAMDC4 and IL1RAP; FGA, CLEC3B, MAMDC4 and HEG1; PDIA4, ITIH3, PEPD and FAP; AREG, ADAM12, IL1RAP and PLXDC2;CEACAM5, ADAMTSL4, HEG1, and PRDX1; FGA, TBCB, MAMDC4, and HEG1; ADAM12, SLAMF8, DCXR, and IL1RAP; SERPINA1, PDIA4, CEACAM5, and HEG1; AREG, TBCB, PKD1, and DCXR; AREG, CEACAM5, HEG1, and IL1RAP; PDIA4, ITIH3, PKD1, and PEPD; SERPINA1, TBCB, SLAMF8, and PLXDC2; AREG, TNC, PKD1, and MAMDC4; SERPINA1, PDIA4, MAMDC4, and PLXDC2; ADAM12, DCXR, IL1RAP, and ALCAM; FGA, SLAMF8, PEPD, and HEG1; PDIA4, IGFBP2, DCXR, and ALCAM; SERPINA1, SLAMF8, PEPD, and DCXR ; PDIA4, ADAMTSL4, PKD1 and DCXR; ADAM12, TNC, FAP and PRDX1; SERPINA1, CLEC3B, IL1RAP and PLXDC2; PDIA4, PRTN3, PEPD and FAP; CEACAM5, SLAMF8, HEG1 and DCXR; PDIA4, MCAM, DCXR and ALCAM; SERPINA1, CEACAM5, HEG1 and IL1RAP; SERPINA1, HEG1, IL1RAP and PLXDC2; AREG, PKD1, DCXR and IL1RAP; AREG, ADAM12, PDIA4 and CD55; ADAM12, MAMDC4, FAP and PRDX1; PDIA4, PEPD, DCXR and IL1RAP; or PDIA4, IGFBP2, CD55 and MCAM (i.e., the 110 4-marker combinations in italics in Table 6).

[0031] Preferably, the A includes a combination of 5 markers, and the combination of 5 markers is any five of the combinations in B.

[0032] Preferably, the 5 markers are combined into a1) and a2):

[0033] a1) the 4-markers combination (preferably any one of the 110 4-markers combinations mentioned above);

[0034] a2) any one of the above B;

[0035] The a2) is different from any one of the markers in the combination of 4 markers in a1).

[0036] Preferably, the five markers combination is: ADAM12, AGR3, MAMDC4, IL1RAP and TNC; PDIA4, PKD1, PEPD, DCXR and TBCB; CEACAM5, TNC, FGA, HEG1 and DCXR; PDIA4, PEPD, DCXR, IL1RAP and TNC; CEACAM5, FGA, PEPD, HEG1 and SERPINA1; ADAM12, PEPD, FAP, PRDX1 and MAMDC4; SERPINA1, PEPD, IL1RAP, PLXDC2 and TNC; PDIA4, PRTN3, PEPD, FAP and DCXR; SERP INA1, ADAM12, IL1RAP, PLXDC2, and TBCB; ADAM12, PDIA4, DCXR, ALCAM, and NCS1; ADAM12, AGR3, MAMDC4, IL1RAP, and LRG1; CEACAM5, ADAMTSL4, HEG1, PRDX1, and PDIA4; PDIA4, PKD1, PEPD, DCXR, and MAMDC4; SERPINA1, AREG, IL1RAP, PLXDC2, and MAMDC4; PDIA4, PEPD, FAP, DCXR, and MCAM; TNC, AGR3, MAMDC4, IL1RAP, and CLEC3B; ADAM12 , AGR3, MAMDC4, IL1RAP and SERPINA1; AREG, ADAM12, TNC, NCS1 and PEPD; PDIA4, PEPD, HEG1, FAP and TNC; PDIA4, PKD1, PEPD, DCXR and FAP; SERPINA1, PDIA4, CEACAM5, HEG1 and MAMDC4; PDIA4, PEPD, FAP, DCXR and TBCB; SERPINA1, CEACAM5, FGA, HEG1 and MAMDC4; PDIA4, PKD1, PRTN3, PEPD and TNC; SERPINA1, MAMDC4, IL1RAP, PLX DC2 and ADAMTSL4; ADAM12, MAMDC4, FAP, PRDX1 and NCS1; ADAM12, AGR3, MAMDC4, IL1RAP and NCS1; PDIA4, PEPD, HEG1, FAP and DCXR; CEACAM5, SLAMF8, PEPD, HEG1 and ADAM12; AREG, PDIA4, DCXR, ALCAM and MAMDC4; PDIA4, PKD1, DCXR, IL1RAP and MAMDC4; FGA, AGR3, SLAMF8, HEG1 and MAMDC4; PDIA4, CEACAM5, PEPD, HEG1 and ADAMTSL4;ADAM12, FGA, MAMDC4, HEG1, and TBCB; AREG, PDIA4, PKD1, DCXR, and MAMDC4; AREG, PDIA4, PKD1, DCXR, and TNC; CEACAM5, AGR3, HEG1, PRDX1, and SLAMF8; PDIA4, PKD1, PEPD, DCXR, and SERPINA1; ADAM12, DCXR, IL1RAP, ALCAM, and TNC; CEACAM5, AGR3, SLAMF8, HEG1, and TBCB; PDIA4, ADAMTSL4, PKD1, DCXR, and MAMDC4; PDIA4, CEACAM5, ME GF9, PEPD, and DCXR; PDIA4, FAP, DCXR, ALCAM, and PEPD; TNC, AGR3, MAMDC4, IL1RAP, and ALCAM; AREG, PKD1, SLAMF8, DCXR, and IGFBP2; TNC, AGR3, MAMDC4, IL1RAP, and MCAM; ADAM12, AGR3, MAMDC4, IL1RAP, and SLAMF8; ADAM12, PDIA4, DCXR, ALCAM, and CLEC3B; PDIA4, IL17RA, DCXR, ALCAM, and AGR3; PDIA4, MCAM, DCXR, ALCAM, and MAMDC4; CE ACAM5, AGR3, HEG1, PRDX1 and DCXR; SERPINA1, HEG1, IL1RAP, PLXDC2 and DCXR; PDIA4, TNC, PEPD, FAP and MCAM; AREG, TBCB, PKD1, DCXR and CEACAM5; SERPINA1, PDIA4, PKD1, DCXR and TBCB; SERPINA1, ADAM12, IL1RAP, PLXDC2 and MAMDC4; PDIA4, PKD1, PEPD, DCXR and TNC; ADAM12, FGA, MAMDC4, HEG1, ADAMTSL4; CEACAM5, AGR3, HEG1, PRDX1 and TNC; AREG, MAMDC4, IL1RAP, PLXDC2 and FAP; TNC, AGR3, MAMDC4, IL1RAP and ADAMTSL4; PDIA4, PKD1, PEPD, DCXR and NCS1; PDIA4, TBCB, PKD1, DCXR and MAMDC4; PDIA4, IGFBP2, PKD1, DCXR and MAMDC4; CEACAM5, AGR3, HEG1, PRDX1 and MAMDC4; FGA, SLAMF8, PEPD, HEG1 and SERPINA1; AREG, ADAM12, PDIA4, CD55 and DCXR;PDIA4, PEPD, FAP, DCXR and SERPINA1; ADAM12, MAMDC4, FAP, PRDX1 and TBCB; ADAM12, FGA, AGR3, IL1RAP and CEACAM5; PDIA4, PKD1, DCXR, IL1RAP and TNC; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and DCXR; PDIA4, CEACAM5, PEPD, HEG1 and MCAM; SERPINA1, HEG1, IL1RAP, PLXDC2 and NCS1; ADAM12, MAMDC4, FAP, PRDX1 and MCAM; PDIA4, C EACAM5, DCXR, ALCAM, and ADAM12; FGA, CLEC3B, MAMDC4, HEG1, and TBCB; ADAM12, PEPD, FAP, PRDX1, and IL17RA; AREG, ADAM12, TNC, NCS1, and DCXR; PDIA4, CLEC3B, PKD1, DCXR, and PEPD; AREG, FGA, HEG1, IL1RAP, and PDIA4; SERPINA1, PKD1, SLAMF8, DCXR, and AGR3; PDIA4, PRTN3, PEPD, FAP, and TBCB; ADAM12, FAP, PRDX1, DCXR, and PEPD; AR EG, PDIA4, PKD1, DCXR, and NCS1; PDIA4, PEPD, DCXR, IL1RAP, and MCAM; AREG, TNC, MAMDC4, NCS1, and TBCB; PDIA4, PKD1, PRTN3, PEPD, and ADAMTSL4; ADAM12, AGR3, MAMDC4, IL1RAP, and CEACAM5; SERPINA1, AREG, FGA, HEG1, and MAMDC4; PDIA4, TBCB, PKD1, DCXR, and ALCAM; PDIA4, TBCB, PEPD, FAP, and TNC; CEACAM5, AGR3, HEG1, PRDX1, and A DAMTSL4; CEACAM5, AGR3, HEG1, PRDX1, and LRG1; ADAM12, FGA, MAMDC4, HEG1, and SERPINA1; FGA, AGR3, SLAMF8, HEG1, and TNC; AREG, PDIA4, CEACAM5, HEG1, and MAMDC4; ADAM12, CEACAM5, FGA, HEG1, and IL17RA; AREG, MAMDC4, IL1RAP, PLXDC2, and TBCB; SERPINA1, CEACAM5, FGA, HEG1, and PDIA4; ADAM12, AGR3, MAMDC4, IL1RAP, and FAP;ADAM12, PDIA4, PKD1, DCXR, and PEPD; ADAM12, AGR3, MAMDC4, IL1RAP, and MCAM; AREG, FGA, PEPD, HEG1, and TBCB; PDIA4, TNC, MCAM, DCXR, and PEPD; ADAM12, FGA, AGR3, IL1RAP, and MAMDC4; PDIA4, CEACAM5, DCXR, ALCAM, and PRDX1; SERPINA1, AREG, FGA, HEG1, and IL17RA; AREG, TNC, PKD1, MAMDC4, and NCS1; TNC, AGR3, MAMDC4, I L1RAP and DCXR; TNC, AGR3, MAMDC4, IL1RAP and FAP; AREG, CEACAM5, FGA, HEG1 and PRDX1; CEACAM5, SLAMF8, PEPD, HEG1 and LRG1; PDIA4, PEPD, FAP, DCXR and CEACAM5; FGA, AGR3, SLAMF8, HEG1 and TBCB; AREG, FGA, PEPD, HEG1 and DCXR; PDIA4, PKD1, PEPD, DCXR and LRG1; CEACAM5, AGR3, SLAMF8, HEG1 and TNC; PDIA4, PEPD, FAP , DCXR and SLAMF8; ADAM12, FGA, MAMDC4, HEG1 and NCS1; AREG, FGA, PEPD, HEG1 and NCS1; ADAM12, FAP, PRDX1, DCXR and ALCAM; ADAM12, PEPD, FAP, PRDX1 and MCAM; ADAM12, CEACAM5, FAP, PRDX1 and PEPD; CEACAM5, ADAMTSL4, SLAMF8, HEG1 and DCXR; AREG, ADAM12, FGA, HEG1 and PEPD; SERPINA1, SLAMF8, DCXR, PLXDC2 and MAMD C4; SERPINA1, PDIA4, PKD1, DCXR, and ALCAM; AREG, PKD1, DCXR, IL1RAP, and PDIA4; CEACAM5, AGR3, SLAMF8, HEG1, and MAMDC4; TNC, AGR3, MAMDC4, IL1RAP, and SERPINA1; PDIA4, DCXR, IL1RAP, ALCAM, and MCAM; PDIA4, PEPD, DCXR, IL1RAP, and CEACAM5; PDIA4, TBCB, PEPD, FAP, and LRG1; ADAM12, AGR3, MAMDC4, IL1RAP, and ITIH3;SERPINA1, PEPD, IL1RAP, PLXDC2, and ALCAM; ADAM12, FGA, SLAMF8, NCS1, and ALCAM; ADAM12, TNC, AGR3, IL1RAP, and ALCAM; PDIA4, FGA, IGFBP2, PKD1, and MAMDC4; AREG, TNC, PKD1, MAMDC4, and PEPD; SERPINA1, CEACAM5, HEG1, IL1RAP, and DCXR; PDIA4, ITIH3, PKD1, PEPD, and MAMDC4; AREG, FGA, PEPD, HEG1, and MCAM; PDIA4, PRTN 3. PEPD, FAP and LRG1; TNC, AGR3, MAMDC4, IL1RAP and PDIA4; SERPINA1, ADAM12, FAP, PRDX1 and DCXR; PDIA4, TBCB, PEPD, FAP and CEACAM5; ADAM12, FGA, MAMDC4, HEG1 and DCXR; PDIA4, CEACAM5, PEPD, HEG1 and DCXR; SERPINA1, SLAMF8, PEPD, DCXR and FAP; PDIA4, CEACAM5, PKD1, DCXR and IL17RA; ADAM12, FGA, FAP, PRDX1 and A GR3; TNC, AGR3, MAMDC4, IL1RAP, and LRG1; PDIA4, TBCB, PKD1, DCXR, and NCS1; SERPINA1, AREG, PKD1, DCXR, and PDIA4; AREG, ADAM12, PDIA4, CD55, and CLEC3B; PDIA4, TNC, PEPD, FAP, and CEACAM5; ADAM12, LRG1, FAP, PRDX1, and IL17RA; FGA, TBCB, MAMDC4, HEG1, and TNC; PDIA4, CEACAM5, PEPD, HEG1, and ADAM12; PDIA4, TNC, ITIH 3. PKD1 and AGR3; SERPINA1, SLAMF8, PEPD, DCXR and MCAM; PDIA4, DCXR, IL1RAP, ALCAM and TBCB; CEACAM5, FGA, HEG1, PRDX1 and MAMDC4; ADAM12, TNC, AGR3, IL1RAP and PEPD; PDIA4, PEPD, DCXR, IL1RAP and TBCB; CEACAM5, AGR3, HEG1, PRDX1 and PEPD; ADAM12, DCXR, IL1RAP, ALCAM and NCS1; PDIA4, FAP, DCXR, ALCAM and PRDX1;SERPINA1, TNC, DCXR, PLXDC2, and ALCAM; ADAM12, CEACAM5, DCXR, IL1RAP, and AGR3; PDIA4, TBCB, PEPD, FAP, and NCS1; ADAM12, FGA, AGR3, IL1RAP, and SERPINA1; ADAM12, TNC, AGR3, IL1RAP, and FAP; PDIA4, FGA, PEPD, HEG1, and ADAMTSL4; ADAM12, FGA, SLAMF8, NCS1, and PDIA4; PDIA4, IGFBP2, DCXR, ALCAM, and MAMDC4; AREG, ADAM 12, FGA, HEG1 and ALCAM; ADAM12, PDIA4, PKD1, DCXR and ALCAM; SERPINA1, ADAM12, IL1RAP, PLXDC2 and AGR3; SERPINA1, PEPD, IL1RAP, PLXDC2 and TBCB; FGA, AGR3, SLAMF8, HEG1 and NCS1; PDIA4, PEPD, HEG1, FAP and SERPINA1; SERPINA1, TNC, DCXR, PLXDC2 and TBCB; FGA, SLAMF8, PEPD, HEG1 and MCAM; SERPINA1, SLAMF8, DCX R, PLXDC2 and FAP; CEACAM5, ADAMTSL4, SLAMF8, HEG1 and MAMDC4; PDIA4, IGFBP2, DCXR, ALCAM and IL17RA; ADAM12, TNC, FAP, PRDX1 and PEPD; PDIA4, ADAMTSL4, PKD1, DCXR and IL17RA; CEACAM5, AGR3, SLAMF8, HEG1 and ADAM12; SERPINA1, SLAMF8, PEPD, DCXR and NCS1; PDIA4, ADAMTSL4, PKD1, DCXR and FAP; FGA, AGR3, SLAMF8 , HEG1 and DCXR; PDIA4, DCXR, IL1RAP, ALCAM and NCS1; PDIA4, PRTN3, PEPD, FAP and NCS1; CEACAM5, TNC, FGA, HEG1 and NCS1; ADAM12, CLEC3B, AGR3, IL1RAP and TBCB; ADAM12, PEPD, FAP, PRDX1 and SERPINA1; ADAM12, FGA, AGR3, IL1RAP and IL17RA; SERPINA1, PDIA4, MAMDC4, PLXDC2 and NCS1; PDIA4, DCXR, IL1RAP, ALCAM and FAP;SERPINA1, AREG, PKD1, DCXR and CEACAM5; PDIA4, FAP, DCXR, ALCAM and ITIH3; CEACAM5, AGR3, HEG1, PRDX1 and PDIA4; SERPINA1, PDIA4, CEACAM5, HEG1 and ALCAM; PDIA4, IL17RA, DCXR, ALCAM and MAMDC4; PDIA4, FGA, PEPD, HEG1 and DCXR; ADAM12, LRG1, FAP, PRDX1 and ALCAM; FGA, AGR3, SLAMF8, HEG1 and CEACAM5; SERPINA1, ADAM 12, FAP, PRDX1 and IGFBP2; SERPINA1, TBCB, SLAMF8, PLXDC2 and MCAM; PDIA4, PEPD, FAP, DCXR and ADAMTSL4; CEACAM5, AGR3, HEG1, PRDX1 and MCAM; SERPINA1, SLAMF8, PEPD, DCXR and CEACAM5; AREG, PKD1, DCXR, IL1RAP and NCS1; PDIA4, CEACAM5, PKD1, DCXR and TBCB; SERPINA1, PEPD, IL1RAP, PLXDC2 and FAP; PDIA4, FGA, IGFBP2, PKD1 and IL17RA; ADAM12, CEACAM5, FGA, HEG1 and PKD1; PDIA4, PEPD, HEG1, FAP and MAMDC4; PDIA4, IL17RA, DCXR, ALCAM and TNC; AREG, PKD1, DCXR, IL1RAP and MAMDC4; AREG, ADAM12, IL1RAP, PLXDC2 and ITIH3; ADAM12, AGR3, MAMDC4, IL1RAP and PRDX1; SERPINA1, PDIA4, CEACAM5, HEG1 and NCS1; ADAM12, CEACAM5, FAP, PRDX1, DCX R;AREG, PKD1, DCXR, IL1RAP and ALCAM; PDIA4, FAP, DCXR, ALCAM and MAMDC4; PDIA4, PEPD, HEG1, FAP and LRG1; ADAM12, TBCB, FAP, PRDX1 and TNC; CEACAM5, SLAMF8, HEG1, DCXR and NCS1; CEACAM5, FGA, HEG1, PRDX1 and ALCAM; PDIA4, TNC, MCAM, DCXR and MAMDC4; FGA, CLEC3B, MAMDC4, HEG1 and PDIA4; AREG, TNC, PKD1, MAMDC4 and TBCB;AREG, PDIA4, DCXR, ALCAM, and CEACAM5; PDIA4, MCAM, DCXR, ALCAM, and PRDX1; ADAM12, FAP, PRDX1, DCXR, and IL17RA; SERPINA1, CEACAM5, CLEC3B, PRDX1, and ALCAM; CEACAM5, FGA, PEPD, HEG1, and AGR3; PDIA4, CEACAM5, PEPD, HEG1, and SLAMF8; PDIA4, TBCB, PEPD, FAP, and ALCAM; PDIA4, PEPD, FAP, DCXR, and LRG1; AREG, ADAM12, P KD1, DCXR and NCS1; CEACAM5, AGR3, SLAMF8, HEG1 and IGFBP2; SERPINA1, PDIA4, CEACAM5, HEG1 and PEPD; ADAM12, MAMDC4, FAP, PRDX1 and IL17RA; ADAM12, AGR3, MAMDC4, IL1RAP and PEPD; SERPINA1, TBCB, SLAMF8, PLXDC2 and PEPD; AREG, PDIA4, PKD1, DCXR and ADAMTSL4; CEACAM5, SLAMF8, HEG1, DCXR and CLEC3B; AREG, ADAM 12, FGA, HEG1 and AGR3; AREG, FGA, HEG1, IL1RAP and PEPD; ADAM12, CLEC3B, AGR3, IL1RAP and PEPD; AREG, PKD1, DCXR, IL1RAP and MCAM; PDIA4, IL17RA, DCXR, ALCAM and ADAMTSL4; AREG, ADAM12, PDIA4, CD55 and NCS1; ADAM12, FGA, AGR3, IL1RAP and TNC; SERPINA1, PEPD, IL1RAP, PLXDC2 and LRG1; AREG, PKD1, DCXR, IL1RAP and P EPD; TNC, AGR3, MAMDC4, IL1RAP and CEACAM5; AREG, TNC, MAMDC4, NCS1 and DCXR; AREG, PKD1, SLAMF8, DCXR and NCS1; AREG, TNC, MAMDC4, NCS1 and ALCAM; PDIA4, PRTN3, PEPD, FAP and ADAMTSL4; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and TBCB; CEACAM5, AGR3, SLAMF8, HEG1 and SERPINA1; PDIA4, CEACAM5, PEPD, HEG1 and CLEC3B;ADAM12, FGA, FAP, PRDX1, and PEPD; TNC, CLEC3B, AGR3, IL1RAP, and ADAMTSL4; CEACAM5, AGR3, SLAMF8, HEG1, and ALCAM; ADAM12, CEACAM5, FAP, PRDX1, and PDIA4; AREG, PDIA4, DCXR, ALCAM, and NCS1; PDIA4, PRTN3, PEPD, FAP, and TNC; SERPINA1, PEPD, IL1RAP, PLXDC2, and MAMDC4; AREG, PKD1, SLAMF8, DCXR, and TBCB; FGA, AGR3, SLAMF 8. HEG1 and PEPD; ADAM12, CLEC3B, AGR3, IL1RAP and MAMDC4; ADAM12, FGA, AGR3, IL1RAP and ALCAM; PDIA4, PRTN3, PEPD, FAP and SERPINA1; ADAM12, CLEC3B, AGR3, IL1RAP and NCS1; SERPINA1, PKD1, SLAMF8, DCXR and TBCB; ADAM12, MAMDC4, FAP, PRDX1 and ADAMTSL4; TNC, CLEC3B, AGR3, IL1RAP and PRDX1; AREG, PKD1, DCXR, IL1RAP and TNC; FGA, AGR3, SLAMF8, HEG1, and ADAMTSL4; ADAM12, SLAMF8, DCXR, IL1RAP, and TBCB; SERPINA1, ADAM12, IL1RAP, PLXDC2, and DCXR; AREG, MAMDC4, IL1RAP, PLXDC2, and CEACAM5; CEACAM5, AGR3, HEG1, PRDX1, and FGA; ADAM12, FGA, FAP, PRDX1, and NCS1; SERPINA1, AREG, IL1RAP, PLXDC2, and AGR3; PDIA4, CEACAM5, MEGF9, PEPD, and AD AM12; SERPINA1, MAMDC4, IL1RAP, PLXDC2, and NCS1; PDIA4, PEPD, DCXR, IL1RAP, and ALCAM; SERPINA1, SLAMF8, PEPD, DCXR, and MAMDC4; AREG, TNC, PKD1, MAMDC4, and FAP; PDIA4, PKD1, PEPD, DCXR, and ADAMTSL4; PDIA4, MCAM, DCXR, ALCAM, and CEACAM5; SERPINA1, CEACAM5, HEG1, IL1RAP, and PEPD; ADAM12, PDIA4, CD55, FAP, and ALCAM;PDIA4, FGA, PKD1, DCXR, and PEPD; SERPINA1, PDIA4, PKD1, DCXR, and MAMDC4; AREG, ADAM12, HEG1, IL1RAP, and PDIA4; AREG, FGA, HEG1, IL1RAP, and NCS1; ADAM12, TNC, AGR3, IL1RAP, and SERPINA1; CEACAM5, ADAMTSL4, SLAMF8, HEG1, and PDIA4; AREG, ADAM12, PKD1, DCXR, and PRDX1; ADAM12, TNC, AGR3, IL1RAP, and ITIH3; CEACA M5, FGA, PEPD, HEG1 and TNC; PDIA4, ADAMTSL4, PKD1, DCXR and NCS1; FGA, SLAMF8, PEPD, HEG1 and LRG1; PDIA4, PKD1, PEPD, DCXR and ALCAM; PDIA4, TNC, IGFBP2, MCAM and MAMDC4; ADAM12, TNC, AGR3, IL1RAP and CEACAM5; AREG, CEACAM5, HEG1, IL1RAP and PRDX1; ADAM12, CEACAM5, FAP, PRDX1 and ITIH3; PDIA4, TBCB, PKD1, DCXR and ITIH3; AREG, TBCB, PKD1, DCXR and TNC; SERPINA1, SLAMF8, PEPD, DCXR and PDIA4; PDIA4, TNC, PEPD, FAP and CLEC3B; AREG, MAMDC4, IL1RAP, PLXDC2 and CLEC3B; PDIA4, TBCB, PKD1, DCXR and IL17RA; CEACAM5, FGA, PEPD, HEG1 and ADAM12; TNC, AGR3, MAMDC4, IL1RAP and PKD1; PDIA4, TNC, MCAM, DCXR and AGR3; PDIA4, PRTN3, PEPD, FAP and MCAM; PDIA4, TNC, MAMDC4, CD55 and DCXR; AREG, PDIA4, DCXR, ALCAM and PEPD; AREG, TNC, MAMDC4, NCS1 and AGR3; SERPINA1, PDIA4, PKD1, DCXR and IL17RA; ADAM12, FGA, MAMDC4, HEG1 and PEPD; AREG, FGA, HEG1, IL1RAP and DCXR; ADAM12, FGA, AGR3, IL1RAP and PEPD; PDIA4, CEACAM5, PKD1, DCXR and NCS1;CEACAM5, ADAMTSL4, HEG1, PRDX1, and IGFBP2; ADAM12, MAMDC4, FAP, PRDX1, and PDIA4; PDIA4, CEACAM5, PKD1, DCXR, and MAMDC4; ADAM12, TNC, AGR3, IL1RAP, and CLEC3B; SERPINA1, MAMDC4, IL1RAP, PLXDC2, and CEACAM5; AREG, ADAM12, HEG1, IL1RAP, and DCXR; SERPINA1, CEACAM5, IL1RAP, PLXDC2, and NCS1; ADAM12, PDIA4, CD55, FA P and AGR3; PDIA4, TBCB, PEPD, FAP and PRDX1; ADAM12, LRG1, FAP, PRDX1 and PDIA4; PDIA4, CEACAM5, MEGF9, PEPD and SLAMF8; PDIA4, PKD1, DCXR, IL1RAP and FAP; AREG, FGA, PEPD, HEG1 and ADAMTSL4; SERPINA1, TNC, DCXR, PLXDC2 and PDIA4; SERPINA1, MEGF9, PRTN3, IL1RAP and AGR3; PDIA4, IGFBP2, PKD1, DCXR and IL17RA; SERPINA 1, PDIA4, PKD1, DCXR and NCS1; PDIA4, TNC, MCAM, DCXR and NCS1; PDIA4, IGFBP2, PKD1, DCXR and ALCAM; PDIA4, PEPD, DCXR, IL1RAP and FAP; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and LRG1; PDIA4, FAP, DCXR, ALCAM and TBCB; AREG, CEACAM5, HEG1, IL1RAP and AGR3; PDIA4, TNC, ITIH3, PKD1 and TBCB; SERPINA1, AREG, IL1RAP, PLXDC2 and TNC; ADAM12, DCXR, IL1RAP, ALCAM, and MAMDC4; PDIA4, TBCB, PEPD, FAP, and AGR3; PDIA4, FGA, IGFBP2, PKD1, and ITIH3; AREG, TNC, PKD1, MAMDC4, and ALCAM; ADAM12, CEACAM5, DCXR, IL1RAP, and SERPINA1; AREG, MAMDC4, IL1RAP, PLXDC2, and MCAM; SERPINA1, CEACAM5, CLEC3B, PRDX1, and AGR3; SERPINA1, SLAMF8, PEPD, DCXR, and ALCAM;PDIA4, PEPD, HEG1, FAP and CEACAM5; AREG, ADAM12, TNC, NCS1 and PRDX1; CEACAM5, FGA, PEPD, HEG1 and DCXR; AREG, TBCB, PKD1, DCXR and NCS1; SERPINA1, HEG1, IL1RAP, PLXDC2 and PDIA4; ADAM12, FGA, SLAMF8, NCS1 and TBCB; ADAM12, SLAMF8, DCXR, IL1RAP and PDIA4; SERPINA1, PKD1, SLAMF8, DCXR and PEPD; AREG, ADAM12, PDIA4, CD55, and AGR3; PDIA4, PKD1, DCXR, IL1RAP, and ADAMTSL4; ADAM12, PDIA4, CD55, FAP, and TBCB; CEACAM5, AGR3, HEG1, PRDX1, and TBCB; FGA, SLAMF8, PEPD, HEG1, and MAMDC4; SERPINA1, SLAMF8, PEPD, DCXR, and TBCB; SERPINA1, PDIA4, MAMDC4, PLXDC2, and PEPD; PDIA4, FAP, DCXR, ALCAM, and NCS1; PDIA4, IL17RA, DCXR, and ALC AM and NCS1; SERPINA1, TBCB, SLAMF8, PLXDC2 and DCXR; SERPINA1, CEACAM5, CLEC3B, PRDX1 and PDIA4; PDIA4, PEPD, DCXR, IL1RAP and PRDX1; SERPINA1, MEGF9, PRTN3, IL1RAP and PEPD; ADAM12, PDIA4, DCXR, ALCAM and AGR3; CEACAM5, AGR3, SLAMF8, HEG1 and NCS1; ADAM12, MAMDC4, FAP, PRDX1 and ALCAM; AREG, TBCB, PKD1, D CXR and FAP; PDIA4, CEACAM5, PKD1, DCXR and AGR3; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and MCAM; SERPINA1, AREG, PKD1, DCXR and ALCAM; AREG, ADAM12, PKD1, DCXR and ALCAM; AREG, PDIA4, DCXR, ALCAM and AGR3; ADAM12, PDIA4, CD55, FAP and PRDX1; SERPINA1, SLAMF8, DCXR, PLXDC2 and TNC; ADAM12, PDIA4, PKD1, DCXR and AGR3;SERPINA1, MAMDC4, IL1RAP, PLXDC2, and ALCAM; SERPINA1, CEACAM5, FGA, HEG1, and DCXR; SERPINA1, MEGF9, PRTN3, IL1RAP, and TNC; CEACAM5, FGA, HEG1, PRDX1, and PEPD; PDIA4, PEPD, FAP, DCXR, and TNC; PDIA4, FGA, IGFBP2, PKD1, and TBCB; SERPINA1, PDIA4, CEACAM5, HEG1, and ADAM12; AREG, ADAM12, HEG1, IL1RAP, and ITIH3; AD AM12, PDIA4, DCXR, ALCAM, and IGFBP2; AREG, PDIA4, PKD1, DCXR, and PEPD; AREG, ADAM12, HEG1, IL1RAP, and MAMDC4; SERPINA1, CEACAM5, IL1RAP, PLXDC2, and ADAM12; FGA, CLEC3B, MAMDC4, HEG1, and PRDX1; SERPINA1, PDIA4, MAMDC4, PLXDC2, and LRG1; SERPINA1, PDIA4, MAMDC4, PLXDC2, and AGR3; SERPINA1, PDIA4, MAMDC4, PL XDC2 and TBCB; AREG, ADAM12, IL1RAP, PLXDC2 and DCXR; SERPINA1, AREG, FGA, HEG1 and PEPD; SERPINA1, MEGF9, PRTN3, IL1RAP and ALCAM; SERPINA1, PDIA4, PKD1, DCXR and AGR3; ADAM12, MAMDC4, FAP, PRDX1 and DCXR; PDIA4, CEACAM5, PEPD, HEG1 and MAMDC4; PDIA4, CEACAM5, MEGF9, PEPD and AGR3; PDIA4, ITIH3, PEPD, FAP and I L17RA; SERPINA1, AREG, PKD1, DCXR, and PEPD; AREG, ADAM12, HEG1, IL1RAP, and ALCAM; CEACAM5, FGA, PEPD, HEG1, and IGFBP2; PDIA4, CEACAM5, PEPD, HEG1, and TBCB; PDIA4, FGA, PKD1, DCXR, and MAMDC4; PDIA4, CEACAM5, PKD1, DCXR, and PEPD; ADAM12, DCXR, IL1RAP, ALCAM, and CEACAM5; SERPINA1, AREG, IL1RAP, PLXDC2, and NCS1;PDIA4, DCXR, IL1RAP, ALCAM and CLEC3B; SERPINA1, SLAMF8, DCXR, PLXDC2 and LRG1; ADAM12, MAMDC4, FAP, PRDX1 and IGFBP2; CEACAM5, TNC, FGA, HEG1 and MAMDC4; SERPINA1, TNC, DCXR, PLXDC2 and FAP; AREG, CEACAM5, FGA, HEG1 and MEGF9; FGA, AGR3, SLAMF8, HEG1 and FAP; SERPINA1, SLAMF8, DCXR, PLXDC2 and ALCAM; SERPINA1, PKD1, SLAMF8, DCXR, and PDIA4; ADAM12, TBCB, FAP, PRDX1, and ITIH3; PDIA4, CLEC3B, PKD1, DCXR, and ALCAM; PDIA4, MCAM, DCXR, ALCAM, and AGR3; FGA, CLEC3B, MAMDC4, HEG1, and IL17RA; SERPINA1, AREG, IL1RAP, PLXDC2, and ALCAM; PDIA4, FGA, IGFBP2, PKD1, and ALCAM; PDIA4, TBCB, PEPD, FAP, and MCAM; AREG, TBCB, PKD1, DCXR, and PEPD; PDIA4, CEACAM5, PKD1, DCXR, and TNC; SERPINA1, SLAMF8, PEPD, DCXR, and ADAMTSL4; AREG, TNC, PKD1, MAMDC4, and DCXR; PDIA4, CEACAM5, DCXR, ALCAM, and PEPD; SERPINA1, TBCB, SLAMF8, PLXDC2, and TNC; AREG, ADAM12, IL1RAP, PLXDC2, and ALCAM; AREG, PKD1, DCXR, IL1RAP, and TBCB; PDIA4, TNC, MAMDC4, CD55, and ADAM12; PDIA4, PKD 1. PRTN3, PEPD and TBCB; ADAM12, FGA, MAMDC4, HEG1 and FAP; PDIA4, PKD1, PRTN3, PEPD and AGR3; PDIA4, CLEC3B, PKD1, DCXR and MAMDC4; SERPINA1, HEG1, IL1RAP, PLXDC2 and PEPD; ADAM12, PDIA4, PKD1, DCXR and NCS1; FGA, SLAMF8, PEPD, HEG1 and ALCAM; SERPINA1, AREG, IL1RAP, PLXDC2 and TBCB; PDIA4, TBCB, PKD1, DCXR and LRG1;PDIA4, PEPD, DCXR, IL1RAP and NCS1; SERPINA1, MEGF9, PRTN3, IL1RAP and NCS1; ADAM12, FGA, AGR3, IL1RAP and DCXR; AREG, ADAM12, PKD1, DCXR and IL17RA; ADAM12, CEACAM5, DCXR, IL1RAP and FGA; TNC, CLEC3B, AGR3, IL1RAP and FAP; FGA, CLEC3B, MAMDC4, HEG1 and AGR3; AREG, MAMDC4, IL1RAP, PLXDC2 and DCXR; CEACAM5, FGA, PEPD, HEG1, and TBCB; AREG, ADAM12, HEG1, IL1RAP, and PEPD; ADAM12, PDIA4, CD55, FAP, and ITIH3; AREG, PDIA4, CEACAM5, HEG1, and PEPD; PDIA4, ITIH3, PKD1, PEPD, and DCXR; CEACAM5, AGR3, HEG1, PRDX1, and SERPINA1; ADAM12, AGR3, MAMDC4, IL1RAP, and DCXR; AREG, TBCB, PKD1, DCXR, and ADAMTSL4; SERPINA1, PKD1, SLAMF 8. DCXR and ALCAM; ADAM12, FGA, SLAMF8, NCS1 and IL17RA; PDIA4, PKD1, PEPD, DCXR and MCAM; CEACAM5, AGR3, HEG1, PRDX1 and CLEC3B; AREG, TBCB, PKD1, DCXR and AGR3; PDIA4, PRTN3, PEPD, FAP and IL17RA; PDIA4, SLAMF8, MCAM, DCXR and PRDX1; FGA, AGR3, SLAMF8, HEG1 and PDIA4; SERPINA1, PDIA4, CEACAM5, HEG1 and ADAMTSL 4; PDIA4, FAP, DCXR, ALCAM and TNC; AREG, ADAM12, IL1RAP, PLXDC2 and AGR3; SERPINA1, PDIA4, PKD1, DCXR and CLEC3B; PDIA4, ADAMTSL4, PKD1, DCXR and SERPINA1; PDIA4, PKD1, DCXR, IL1RAP and IL17RA; ADAM12, TNC, FAP, PRDX1 and NCS1; SERPINA1, SLAMF8, DCXR, PLXDC2 and AGR3; FGA, CLEC3B, MAMDC4, HEG1 and CEACAM5;ADAM12, CEACAM5, DCXR, IL1RAP, and LRG1; ADAM12, FGA, SLAMF8, NCS1, and SERPINA1; ADAM12, PDIA4, CD55, FAP, and IL17RA; SERPINA1, PEPD, IL1RAP, PLXDC2, and MCAM; PDIA4, PEPD, DCXR, IL1RAP, and MAMDC4; PDIA4, PEPD, DCXR, IL1RAP, and IGFBP2; ADAM12, SLAMF8, DCXR, IL1RAP, and LRG1; AREG, PDIA4, CEACAM5, HEG1, and NCS1 ; PDIA4, TNC, MCAM, DCXR and PRDX1; PDIA4, CEACAM5, PEPD, HEG1 and PRDX1; SERPINA1, CEACAM5, CLEC3B, PRDX1 and IGFBP2; PDIA4, ITIH3, PEPD, FAP and ALCAM; CEACAM5, AGR3, SLAMF8, HEG1 and LRG1; PDIA4, CEACAM5, DCXR, ALCAM and MAMDC4; SERPINA1, PEPD, IL1RAP, PLXDC2 and DCXR; FGA, SLAMF8, PEPD, HEG1 and CLEC3B; A DAM12, DCXR, IL1RAP, ALCAM, and ITIH3; AREG, ADAM12, PKD1, DCXR, and MCAM; PDIA4, SLAMF8, MCAM, DCXR, and FAP; ADAM12, TNC, AGR3, IL1RAP, and TBCB; PDIA4, SLAMF8, MCAM, DCXR, and SERPINA1; PDIA4, FGA, PKD1, DCXR, and TBCB; PDIA4, FGA, PEPD, HEG1, and TNC; CEACAM5, ADAMTSL4, HEG1, PRDX1, and MAMDC4; ADAM12, MAMDC4, and FAP , PRDX1 and CLEC3B; PDIA4, PKD1, PRTN3, PEPD and NCS1; PDIA4, TBCB, PKD1, DCXR and ADAM12; ADAM12, CEACAM5, FGA, HEG1 and DCXR; AREG, ADAM12, FGA, HEG1 and PDIA4; CEACAM5, FGA, HEG1, PRDX1 and SERPINA1; CEACAM5, AGR3, SLAMF8, HEG1 and ADAMTSL4; PDIA4, TNC, MAMDC4, CD55 and NCS1; ADAM12, PEPD, FAP, PRDX1 and PDIA4;FGA, SLAMF8, PEPD, HEG1 and TNC; AREG, PDIA4, PKD1, DCXR and CEACAM5; SERPINA1, AREG, PKD1, DCXR and NCS1; PDIA4, TBCB, PKD1, DCXR and TNC; ADAM12, FGA, AGR3, IL1RAP and CLEC3B; PDIA4, IGFBP2, DCXR, ALCAM and TNC; AREG, ADAM12, HEG1, IL1RAP and PRDX1; PDIA4, CEACAM5, MEGF9, PEPD and NCS1; ADAM12, PDIA4, DCXR, ALCAM and IL17RA; SERPINA1, ADAM12, FAP, PRDX1, and TBCB; PDIA4, CEACAM5, PKD1, DCXR, and FGA; AREG, ADAM12, IL1RAP, PLXDC2, and PDIA4; PDIA4, FGA, PKD1, DCXR, and ASPN; CEACAM5, ADAMTSL4, HEG1, PRDX1, and IL17RA; ADAM12, AGR3, MAMDC4, IL1RAP, and PDIA4; AREG, TNC, MAMDC4, NCS1, and ITIH3; SERPINA1, AREG, FGA, and HEG1 and PDIA4; PDIA4, CEACAM5, PEPD, HEG1, and NCS1; CEACAM5, SLAMF8, PEPD, HEG1, and IGFBP2; SERPINA1, MAMDC4, IL1RAP, PLXDC2, and PDIA4; ADAM12, FGA, SLAMF8, NCS1, and DCXR; PDIA4, PKD1, DCXR, IL1RAP, and PEPD; PDIA4, PEPD, FAP, DCXR, and NCS1; TNC, CLEC3B, AGR3, IL1RAP, and CEACAM5; SERPINA1, ADAM12, FAP, PRDX1, and PDI A4; PDIA4, PKD1, PRTN3, PEPD and PRDX1; SERPINA1, PDIA4, CEACAM5, HEG1 and SLAMF8; ADAM12, FGA, AGR3, IL1RAP and PRDX1; PDIA4, ITIH3, PEPD, FAP and CEACAM5; CEACAM5, FGA, HEG1, PRDX1 and IL17RA; ADAM12, FGA, AGR3, IL1RAP and ADAMTSL4; TNC, AGR3, MAMDC4, IL1RAP and IGFBP2; ADAM12, PDIA4, CD55, FAP and MAMDC4;AREG, ADAM12, PKD1, DCXR and CLEC3B; SERPINA1, PKD1, SLAMF8, DCXR and LRG1; CEACAM5, SLAMF8, PEPD, HEG1 and TNC; AREG, TNC, MAMDC4, NCS1 and MCAM; TNC, AGR3, MAMDC4, IL1RAP and FGA; ADAM12, LRG1, FAP, PRDX1 and DCXR; PDIA4, ADAMTSL4, PKD1, DCXR and AGR3; AREG, TNC, PKD1, MAMDC4 and IGFBP2; ADAM12, TBCB, FAP, PRDX1 and DCXR; AREG, PDIA4, PKD1, DCXR and ALCAM; FGA, TBCB, MAMDC4, HEG1 and SERPINA1; ADAM12, TNC, AGR3, IL1RAP and PDIA4; SERPINA1, MEGF9, PRTN3, IL1RAP and MCAM; PDIA4, ITIH3, PKD1, PEPD and IGFBP2; PDIA4, PEPD, DCXR, IL1RAP and ADAMTSL4; AREG, MAMDC4, IL1RAP, PLXDC2 and ALCAM; ADAM12, DCXR, IL1RAP, AL CAM and ADAMTSL4; PDIA4, CEACAM5, DCXR, ALCAM and NCS1; ADAM12, CEACAM5, DCXR, IL1RAP and PRDX1; CEACAM5, SLAMF8, HEG1, DCXR and AGR3; SERPINA1, PEPD, IL1RAP, PLXDC2 and ITIH3; SERPINA1, HEG1, IL1RAP, PLXDC2 and ALCAM; ADAM12, FGA, FAP, PRDX1 and PDIA4; PDIA4, TNC, MAMDC4, CD55 and TBCB; AREG, FGA, PEPD, H EG1 and MAMDC4; FGA, AGR3, SLAMF8, HEG1 and LRG1; ADAM12, PDIA4, DCXR, ALCAM and MCAM; CEACAM5, SLAMF8, HEG1, DCXR and ALCAM; SERPINA1, CEACAM5, FGA, HEG1 and MCAM; ADAM12, TNC, FAP, PRDX1 and IGFBP2; ADAM12, SLAMF8, DCXR, IL1RAP and MAMDC4; AREG, PDIA4, DCXR, ALCAM and ADAM12; AREG, TBCB, PKD1, DCXR and ALCAM;AREG, MAMDC4, IL1RAP, PLXDC2, and PEPD; AREG, PDIA4, CEACAM5, HEG1, and DCXR; PDIA4, TBCB, PEPD, FAP, and ADAMTSL4; SERPINA1, CLEC3B, IL1RAP, PLXDC2, and DCXR; PDIA4, PKD1, DCXR, IL1RAP, and NCS1; AREG, MAMDC4, IL1RAP, PLXDC2, and PDIA4; SERPINA1, TNC, DCXR, PLXDC2, and AGR3; ADAM12, CLEC3B, AGR3, IL1RAP, and CEACAM5; P DIA4, FGA, PKD1, DCXR, and ADAMTSL4; PDIA4, ITIH3, PKD1, PEPD, and FAP; PDIA4, FGA, PKD1, DCXR, and LRG1; PDIA4, CEACAM5, MEGF9, PEPD, and ALCAM; ADAM12, FGA, MAMDC4, HEG1, and TNC; CEACAM5, FGA, HEG1, PRDX1, and PDIA4; ADAM12, CEACAM5, FAP, PRDX1, and ADAMTSL4; PDIA4, TNC, MCAM, DCXR, and CLEC3B; PDIA4, TNC, MAMDC4, CD55, and F GA; AREG, FGA, HEG1, IL1RAP and FAP; CEACAM5, FGA, PEPD, HEG1 and ALCAM; AREG, MAMDC4, IL1RAP, PLXDC2 and ITIH3; PDIA4, PKD1, PRTN3, PEPD and MAMDC4; PDIA4, TNC, PEPD, FAP and ALCAM; AREG, FGA, PEPD, HEG1 and CEACAM5; CEACAM5, AGR3, HEG1, PRDX1 and ALCAM; SERPINA1, CEACAM5, FGA, HEG1 and ASPN; SERPINA1, CEACAM5, CL EC3B, PRDX1, and MAMDC4; ADAM12, FGA, FAP, PRDX1, and IL17RA; PDIA4, FGA, PKD1, DCXR, and NCS1; AREG, MAMDC4, IL1RAP, PLXDC2, and TNC; PDIA4, DCXR, IL1RAP, ALCAM, and MAMDC4; SERPINA1, CEACAM5, FGA, HEG1, and AGR3; PDIA4, SLAMF8, MCAM, DCXR, and AGR3; AREG, ADAM12, PKD1, DCXR, and SERPINA1; PDIA4, IGFBP2, CD55, MCAM, and DCXR;PDIA4, FGA, PKD1, DCXR and ALCAM; PDIA4, TNC, MAMDC4, CD55 and ADAMTSL4; PDIA4, TNC, IGFBP2, MCAM and ADAMTSL4; PDIA4, IGFBP2, PKD1, DCXR and LRG1; PDIA4, CEACAM5, PKD1, DCXR and LRG1; AREG, ADAM12, PKD1, DCXR and CEACAM5; ADAM12, DCXR, IL1RAP, ALCAM and PRDX1; ADAM12, CLEC3B, AGR3, IL1RAP and ADAMTSL4; PDIA4, PEPD, FAP, DCXR, and AGR3; TNC, AGR3, MAMDC4, IL1RAP, and TBCB; ADAM12, PDIA4, DCXR, ALCAM, and ADAMTSL4; CEACAM5, FGA, PEPD, HEG1, and NCS1; SERPINA1, PDIA4, MAMDC4, PLXDC2, and ALCAM; AREG, PDIA4, CEACAM5, HEG1, and PRDX1; ADAM12, TBCB, FAP, PRDX1, and CLEC3B; PDIA4, PEPD, HEG1, FAP, and PRDX1; TNC, AGR3, MAMDC4, and IL1RA P and PEPD; ADAM12, CEACAM5, FGA, HEG1 and PDIA4; PDIA4, IGFBP2, DCXR, ALCAM and TBCB; CEACAM5, SLAMF8, PEPD, HEG1 and IL17RA; PDIA4, FGA, PEPD, HEG1 and TBCB; ADAM12, FGA, SLAMF8, NCS1 and ITIH3; AREG, TBCB, PKD1, DCXR and PDIA4; PDIA4, PKD1, PRTN3, PEPD and DCXR; PDIA4, PEPD, FAP, DCXR and CLEC3B; PDIA4, SLAMF8, MCA M, DCXR and MAMDC4; AREG, PDIA4, DCXR, ALCAM and TBCB; SERPINA1, HEG1, IL1RAP, PLXDC2 and ITIH3; SERPINA1, ADAM12, FAP, PRDX1 and MAMDC4; ADAM12, PDIA4, DCXR, ALCAM and TBCB; ADAM12, FGA, FAP, PRDX1 and MAMDC4; AREG, PKD1, DCXR, IL1RAP and FAP; ADAM12, PDIA4, PKD1, DCXR and ITIH3; PDIA4, CLEC3B, PKD1, DCXR and AGR3;PDIA4, TNC, ITIH3, PKD1 and MAMDC4; SERPINA1, SLAMF8, PEPD, DCXR and IL17RA; FGA, TBCB, MAMDC4, HEG1 and AGR3; PDIA4, TNC, PEPD, FAP and AGR3; SERPINA1, AREG, PKD1, DCXR and ADAMTSL4; FGA, AGR3, SLAMF8, HEG1 and SERPINA1; PDIA4TBCB, PKD1, DCXR and PEPD, PDIA4, TBCB, PEPD, FAP and DCXR, SERPINA 1. PDIA4, PKD1, DCXR and PEPD, ADAM12, TNC, AGR3, IL1RAP and MAMDC4, ADAM12, AGR3, MAMDC4, IL1RAP and FGA, ADAM12, TBCB, FAP, PRDX1 and MAMDC4, PDIA4, PKD1, PEPD, DCXR and ADAM12, TNC, CLEC3B, AGR3, IL1RAP and MAMDC4, CEACAM5, ADAMTSL4, HEG1, PRDX1 and AGR3, PDIA4, DCXR, IL1RAP, ALCAM and PEPD ,SERPINA1, MAMDC4, IL1RAP, PLXDC2 and PEPD,CEACAM5, AGR3, SLAMF8, HEG1 and FGA,PDIA4, TBCB, PKD1, DCXR and CEACAM5,PDIA4, TNC, PEPD, FAP and TBCB,ADAM12, PDIA4, PKD1, DCXR and TBCB,ADAM12, PEPD, FAP, PRDX1 and DCXR,PDIA4, TNC, PEPD, FAP and DCXR,PDIA4, PKD1, PEPD, DCXR and CEACAM5,AREG, MAMDC4, IL1RAP, PLXDC2 and SERPINA1, CEACAM5, SLAMF8, HEG1, DCXR and ADAMTSL4, TNC, AGR3, MAMDC4, IL1RAP and ADAM12, ADAM12, MAMDC4, FAP, PRDX1 and PEPD, ADAM12, PDIA4, DCXR, ALCAM and CEACAM5, PDIA4, CEACAM5, PEPD, HEG1 and FAP, or CEACAM5, TNC, FGA, HEG1 and PEPD (i.e., 699 5-marker combinations in Table 7).

[0037] Preferably, the five markers combination is: ADAM12, AGR3, MAMDC4, IL1RAP and TNC; PDIA4, PKD1, PEPD, DCXR and TBCB; CEACAM5, TNC, FGA, HEG1 and DCXR; PDIA4, PEPD, DCXR, IL1RAP and TNC; CEACAM5, FGA, PEPD, HEG1 and SERPINA1; ADAM12, PEPD, FAP, PRDX1 and MAMDC4; SERPINA1, PEPD, IL1RAP, PLXDC2 and TNC; PDIA4, PRTN3, PEPD, FAP and DCXR; SERP INA1, ADAM12, IL1RAP, PLXDC2, and TBCB; ADAM12, PDIA4, DCXR, ALCAM, and NCS1; ADAM12, AGR3, MAMDC4, IL1RAP, and LRG1; CEACAM5, ADAMTSL4, HEG1, PRDX1, and PDIA4; PDIA4, PKD1, PEPD, DCXR, and MAMDC4; SERPINA1, AREG, IL1RAP, PLXDC2, and MAMDC4; PDIA4, PEPD, FAP, DCXR, and MCAM; TNC, AGR3, MAMDC4, IL1RAP, and CLEC3B; ADAM12 , AGR3, MAMDC4, IL1RAP and SERPINA1; AREG, ADAM12, TNC, NCS1 and PEPD; PDIA4, PEPD, HEG1, FAP and TNC; PDIA4, PKD1, PEPD, DCXR and FAP; SERPINA1, PDIA4, CEACAM5, HEG1 and MAMDC4; PDIA4, PEPD, FAP, DCXR and TBCB; SERPINA1, CEACAM5, FGA, HEG1 and MAMDC4; PDIA4, PKD1, PRTN3, PEPD and TNC; SERPINA1, MAMDC4, IL1RAP, PLX DC2 and ADAMTSL4; ADAM12, MAMDC4, FAP, PRDX1 and NCS1; ADAM12, AGR3, MAMDC4, IL1RAP and NCS1; PDIA4, PEPD, HEG1, FAP and DCXR; CEACAM5, SLAMF8, PEPD, HEG1 and ADAM12; AREG, PDIA4, DCXR, ALCAM and MAMDC4; PDIA4, PKD1, DCXR, IL1RAP and MAMDC4; FGA, AGR3, SLAMF8, HEG1 and MAMDC4; PDIA4, CEACAM5, PEPD, HEG1 and ADAMTSL4;ADAM12, FGA, MAMDC4, HEG1, and TBCB; AREG, PDIA4, PKD1, DCXR, and MAMDC4; AREG, PDIA4, PKD1, DCXR, and TNC; CEACAM5, AGR3, HEG1, PRDX1, and SLAMF8; PDIA4, PKD1, PEPD, DCXR, and SERPINA1; ADAM12, DCXR, IL1RAP, ALCAM, and TNC; CEACAM5, AGR3, SLAMF8, HEG1, and TBCB; PDIA4, ADAMTSL4, PKD1, DCXR, and MAMDC4; PDIA4, CEACAM5, ME GF9, PEPD, and DCXR; PDIA4, FAP, DCXR, ALCAM, and PEPD; TNC, AGR3, MAMDC4, IL1RAP, and ALCAM; AREG, PKD1, SLAMF8, DCXR, and IGFBP2; TNC, AGR3, MAMDC4, IL1RAP, and MCAM; ADAM12, AGR3, MAMDC4, IL1RAP, and SLAMF8; ADAM12, PDIA4, DCXR, ALCAM, and CLEC3B; PDIA4, IL17RA, DCXR, ALCAM, and AGR3; PDIA4, MCAM, DCXR, ALCAM, and MAMDC4; CE ACAM5, AGR3, HEG1, PRDX1 and DCXR; SERPINA1, HEG1, IL1RAP, PLXDC2 and DCXR; PDIA4, TNC, PEPD, FAP and MCAM; AREG, TBCB, PKD1, DCXR and CEACAM5; SERPINA1, PDIA4, PKD1, DCXR and TBCB; SERPINA1, ADAM12, IL1RAP, PLXDC2 and MAMDC4; PDIA4, PKD1, PEPD, DCXR and TNC; ADAM12, FGA, MAMDC4, HEG1, ADAMTSL4; CEACAM5, AGR3, HEG1, PRDX1 and TNC; AREG, MAMDC4, IL1RAP, PLXDC2 and FAP; TNC, AGR3, MAMDC4, IL1RAP and ADAMTSL4; PDIA4, PKD1, PEPD, DCXR and NCS1; PDIA4, TBCB, PKD1, DCXR and MAMDC4; PDIA4, IGFBP2, PKD1, DCXR and MAMDC4; CEACAM5, AGR3, HEG1, PRDX1 and MAMDC4; FGA, SLAMF8, PEPD, HEG1 and SERPINA1; AREG, ADAM12, PDIA4, CD55 and DCXR;PDIA4, PEPD, FAP, DCXR and SERPINA1; ADAM12, MAMDC4, FAP, PRDX1 and TBCB; ADAM12, FGA, AGR3, IL1RAP and CEACAM5; PDIA4, PKD1, DCXR, IL1RAP and TNC; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and DCXR; PDIA4, CEACAM5, PEPD, HEG1 and MCAM; SERPINA1, HEG1, IL1RAP, PLXDC2 and NCS1; ADAM12, MAMDC4, FAP, PRDX1 and MCAM; PDIA4, C EACAM5, DCXR, ALCAM, and ADAM12; FGA, CLEC3B, MAMDC4, HEG1, and TBCB; ADAM12, PEPD, FAP, PRDX1, and IL17RA; AREG, ADAM12, TNC, NCS1, and DCXR; PDIA4, CLEC3B, PKD1, DCXR, and PEPD; AREG, FGA, HEG1, IL1RAP, and PDIA4; SERPINA1, PKD1, SLAMF8, DCXR, and AGR3; PDIA4, PRTN3, PEPD, FAP, and TBCB; ADAM12, FAP, PRDX1, DCXR, and PEPD; AR EG, PDIA4, PKD1, DCXR, and NCS1; PDIA4, PEPD, DCXR, IL1RAP, and MCAM; AREG, TNC, MAMDC4, NCS1, and TBCB; PDIA4, PKD1, PRTN3, PEPD, and ADAMTSL4; ADAM12, AGR3, MAMDC4, IL1RAP, and CEACAM5; SERPINA1, AREG, FGA, HEG1, and MAMDC4; PDIA4, TBCB, PKD1, DCXR, and ALCAM; PDIA4, TBCB, PEPD, FAP, and TNC; CEACAM5, AGR3, HEG1, PRDX1, and A DAMTSL4; CEACAM5, AGR3, HEG1, PRDX1, and LRG1; ADAM12, FGA, MAMDC4, HEG1, and SERPINA1; FGA, AGR3, SLAMF8, HEG1, and TNC; AREG, PDIA4, CEACAM5, HEG1, and MAMDC4; ADAM12, CEACAM5, FGA, HEG1, and IL17RA; AREG, MAMDC4, IL1RAP, PLXDC2, and TBCB; SERPINA1, CEACAM5, FGA, HEG1, and PDIA4; ADAM12, AGR3, MAMDC4, IL1RAP, and FAP;ADAM12, PDIA4, PKD1, DCXR, and PEPD; ADAM12, AGR3, MAMDC4, IL1RAP, and MCAM; AREG, FGA, PEPD, HEG1, and TBCB; PDIA4, TNC, MCAM, DCXR, and PEPD; ADAM12, FGA, AGR3, IL1RAP, and MAMDC4; PDIA4, CEACAM5, DCXR, ALCAM, and PRDX1; SERPINA1, AREG, FGA, HEG1, and IL17RA; AREG, TNC, PKD1, MAMDC4, and NCS1; TNC, AGR3, MAMDC4, I L1RAP and DCXR; TNC, AGR3, MAMDC4, IL1RAP and FAP; AREG, CEACAM5, FGA, HEG1 and PRDX1; CEACAM5, SLAMF8, PEPD, HEG1 and LRG1; PDIA4, PEPD, FAP, DCXR and CEACAM5; FGA, AGR3, SLAMF8, HEG1 and TBCB; AREG, FGA, PEPD, HEG1 and DCXR; PDIA4, PKD1, PEPD, DCXR and LRG1; CEACAM5, AGR3, SLAMF8, HEG1 and TNC; PDIA4, PEPD, FAP , DCXR and SLAMF8; ADAM12, FGA, MAMDC4, HEG1 and NCS1; AREG, FGA, PEPD, HEG1 and NCS1; ADAM12, FAP, PRDX1, DCXR and ALCAM; ADAM12, PEPD, FAP, PRDX1 and MCAM; ADAM12, CEACAM5, FAP, PRDX1 and PEPD; CEACAM5, ADAMTSL4, SLAMF8, HEG1 and DCXR; AREG, ADAM12, FGA, HEG1 and PEPD; SERPINA1, SLAMF8, DCXR, PLXDC2 and MAMD C4; SERPINA1, PDIA4, PKD1, DCXR, and ALCAM; AREG, PKD1, DCXR, IL1RAP, and PDIA4; CEACAM5, AGR3, SLAMF8, HEG1, and MAMDC4; TNC, AGR3, MAMDC4, IL1RAP, and SERPINA1; PDIA4, DCXR, IL1RAP, ALCAM, and MCAM; PDIA4, PEPD, DCXR, IL1RAP, and CEACAM5; PDIA4, TBCB, PEPD, FAP, and LRG1; ADAM12, AGR3, MAMDC4, IL1RAP, and ITIH3;SERPINA1, PEPD, IL1RAP, PLXDC2, and ALCAM; ADAM12, FGA, SLAMF8, NCS1, and ALCAM; ADAM12, TNC, AGR3, IL1RAP, and ALCAM; PDIA4, FGA, IGFBP2, PKD1, and MAMDC4; AREG, TNC, PKD1, MAMDC4, and PEPD; SERPINA1, CEACAM5, HEG1, IL1RAP, and DCXR; PDIA4, ITIH3, PKD1, PEPD, and MAMDC4; AREG, FGA, PEPD, HEG1, and MCAM; PDIA4, PRTN 3. PEPD, FAP and LRG1; TNC, AGR3, MAMDC4, IL1RAP and PDIA4; SERPINA1, ADAM12, FAP, PRDX1 and DCXR; PDIA4, TBCB, PEPD, FAP and CEACAM5; ADAM12, FGA, MAMDC4, HEG1 and DCXR; PDIA4, CEACAM5, PEPD, HEG1 and DCXR; SERPINA1, SLAMF8, PEPD, DCXR and FAP; PDIA4, CEACAM5, PKD1, DCXR and IL17RA; ADAM12, FGA, FAP, PRDX1 and A GR3; TNC, AGR3, MAMDC4, IL1RAP, and LRG1; PDIA4, TBCB, PKD1, DCXR, and NCS1; SERPINA1, AREG, PKD1, DCXR, and PDIA4; AREG, ADAM12, PDIA4, CD55, and CLEC3B; PDIA4, TNC, PEPD, FAP, and CEACAM5; ADAM12, LRG1, FAP, PRDX1, and IL17RA; FGA, TBCB, MAMDC4, HEG1, and TNC; PDIA4, CEACAM5, PEPD, HEG1, and ADAM12; PDIA4, TNC, ITIH 3. PKD1 and AGR3; SERPINA1, SLAMF8, PEPD, DCXR and MCAM; PDIA4, DCXR, IL1RAP, ALCAM and TBCB; CEACAM5, FGA, HEG1, PRDX1 and MAMDC4; ADAM12, TNC, AGR3, IL1RAP and PEPD; PDIA4, PEPD, DCXR, IL1RAP and TBCB; CEACAM5, AGR3, HEG1, PRDX1 and PEPD; ADAM12, DCXR, IL1RAP, ALCAM and NCS1; PDIA4, FAP, DCXR, ALCAM and PRDX1;SERPINA1, TNC, DCXR, PLXDC2, and ALCAM; ADAM12, CEACAM5, DCXR, IL1RAP, and AGR3; PDIA4, TBCB, PEPD, FAP, and NCS1; ADAM12, FGA, AGR3, IL1RAP, and SERPINA1; ADAM12, TNC, AGR3, IL1RAP, and FAP; PDIA4, FGA, PEPD, HEG1, and ADAMTSL4; ADAM12, FGA, SLAMF8, NCS1, and PDIA4; PDIA4, IGFBP2, DCXR, ALCAM, and MAMDC4; AREG, ADAM 12, FGA, HEG1 and ALCAM; ADAM12, PDIA4, PKD1, DCXR and ALCAM; SERPINA1, ADAM12, IL1RAP, PLXDC2 and AGR3; SERPINA1, PEPD, IL1RAP, PLXDC2 and TBCB; FGA, AGR3, SLAMF8, HEG1 and NCS1; PDIA4, PEPD, HEG1, FAP and SERPINA1; SERPINA1, TNC, DCXR, PLXDC2 and TBCB; FGA, SLAMF8, PEPD, HEG1 and MCAM; SERPINA1, SLAMF8, DCX R, PLXDC2 and FAP; CEACAM5, ADAMTSL4, SLAMF8, HEG1 and MAMDC4; PDIA4, IGFBP2, DCXR, ALCAM and IL17RA; ADAM12, TNC, FAP, PRDX1 and PEPD; PDIA4, ADAMTSL4, PKD1, DCXR and IL17RA; CEACAM5, AGR3, SLAMF8, HEG1 and ADAM12; SERPINA1, SLAMF8, PEPD, DCXR and NCS1; PDIA4, ADAMTSL4, PKD1, DCXR and FAP; FGA, AGR3, SLAMF8 , HEG1 and DCXR; PDIA4, DCXR, IL1RAP, ALCAM and NCS1; PDIA4, PRTN3, PEPD, FAP and NCS1; CEACAM5, TNC, FGA, HEG1 and NCS1; ADAM12, CLEC3B, AGR3, IL1RAP and TBCB; ADAM12, PEPD, FAP, PRDX1 and SERPINA1; ADAM12, FGA, AGR3, IL1RAP and IL17RA; SERPINA1, PDIA4, MAMDC4, PLXDC2 and NCS1; PDIA4, DCXR, IL1RAP, ALCAM and FAP;SERPINA1, AREG, PKD1, DCXR and CEACAM5; PDIA4, FAP, DCXR, ALCAM and ITIH3; CEACAM5, AGR3, HEG1, PRDX1 and PDIA4; SERPINA1, PDIA4, CEACAM5, HEG1 and ALCAM; PDIA4, IL17RA, DCXR, ALCAM and MAMDC4; PDIA4, FGA, PEPD, HEG1 and DCXR; ADAM12, LRG1, FAP, PRDX1 and ALCAM; FGA, AGR3, SLAMF8, HEG1 and CEACAM5; SERPINA1, ADAM 12, FAP, PRDX1 and IGFBP2; SERPINA1, TBCB, SLAMF8, PLXDC2 and MCAM; PDIA4, PEPD, FAP, DCXR and ADAMTSL4; CEACAM5, AGR3, HEG1, PRDX1 and MCAM; SERPINA1, SLAMF8, PEPD, DCXR and CEACAM5; AREG, PKD1, DCXR, IL1RAP and NCS1; PDIA4, CEACAM5, PKD1, DCXR and TBCB; SERPINA1, PEPD, IL1RAP, PLXDC2 and FAP; PDIA4, FGA, IGFBP2, PKD1 and IL17RA; ADAM12, CEACAM5, FGA, HEG1 and PKD1; PDIA4, PEPD, HEG1, FAP and MAMDC4; PDIA4, IL17RA, DCXR, ALCAM and TNC; AREG, PKD1, DCXR, IL1RAP and MAMDC4; AREG, ADAM12, IL1RAP, PLXDC2 and ITIH3; ADAM12, AGR3, MAMDC4, IL1RAP and PRDX1; SERPINA1, PDIA4, CEACAM5, HEG1 and NCS1; ADAM12, CEACAM5, FAP, PRDX1, DCX R;AREG, PKD1, DCXR, IL1RAP and ALCAM; PDIA4, FAP, DCXR, ALCAM and MAMDC4; PDIA4, PEPD, HEG1, FAP and LRG1; ADAM12, TBCB, FAP, PRDX1 and TNC; CEACAM5, SLAMF8, HEG1, DCXR and NCS1; CEACAM5, FGA, HEG1, PRDX1 and ALCAM; PDIA4, TNC, MCAM, DCXR and MAMDC4; FGA, CLEC3B, MAMDC4, HEG1 and PDIA4; AREG, TNC, PKD1, MAMDC4 and TBCB;AREG, PDIA4, DCXR, ALCAM, and CEACAM5; PDIA4, MCAM, DCXR, ALCAM, and PRDX1; ADAM12, FAP, PRDX1, DCXR, and IL17RA; SERPINA1, CEACAM5, CLEC3B, PRDX1, and ALCAM; CEACAM5, FGA, PEPD, HEG1, and AGR3; PDIA4, CEACAM5, PEPD, HEG1, and SLAMF8; PDIA4, TBCB, PEPD, FAP, and ALCAM; PDIA4, PEPD, FAP, DCXR, and LRG1; AREG, ADAM12, P KD1, DCXR and NCS1; CEACAM5, AGR3, SLAMF8, HEG1 and IGFBP2; SERPINA1, PDIA4, CEACAM5, HEG1 and PEPD; ADAM12, MAMDC4, FAP, PRDX1 and IL17RA; ADAM12, AGR3, MAMDC4, IL1RAP and PEPD; SERPINA1, TBCB, SLAMF8, PLXDC2 and PEPD; AREG, PDIA4, PKD1, DCXR and ADAMTSL4; CEACAM5, SLAMF8, HEG1, DCXR and CLEC3B; AREG, ADAM 12, FGA, HEG1 and AGR3; AREG, FGA, HEG1, IL1RAP and PEPD; ADAM12, CLEC3B, AGR3, IL1RAP and PEPD; AREG, PKD1, DCXR, IL1RAP and MCAM; PDIA4, IL17RA, DCXR, ALCAM and ADAMTSL4; AREG, ADAM12, PDIA4, CD55 and NCS1; ADAM12, FGA, AGR3, IL1RAP and TNC; SERPINA1, PEPD, IL1RAP, PLXDC2 and LRG1; AREG, PKD1, DCXR, IL1RAP and P EPD; TNC, AGR3, MAMDC4, IL1RAP and CEACAM5; AREG, TNC, MAMDC4, NCS1 and DCXR; AREG, PKD1, SLAMF8, DCXR and NCS1; AREG, TNC, MAMDC4, NCS1 and ALCAM; PDIA4, PRTN3, PEPD, FAP and ADAMTSL4; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and TBCB; CEACAM5, AGR3, SLAMF8, HEG1 and SERPINA1; PDIA4, CEACAM5, PEPD, HEG1 and CLEC3B;ADAM12, FGA, FAP, PRDX1, and PEPD; TNC, CLEC3B, AGR3, IL1RAP, and ADAMTSL4; CEACAM5, AGR3, SLAMF8, HEG1, and ALCAM; ADAM12, CEACAM5, FAP, PRDX1, and PDIA4; AREG, PDIA4, DCXR, ALCAM, and NCS1; PDIA4, PRTN3, PEPD, FAP, and TNC; SERPINA1, PEPD, IL1RAP, PLXDC2, and MAMDC4; AREG, PKD1, SLAMF8, DCXR, and TBCB; FGA, AGR3, SLAMF 8. HEG1 and PEPD; ADAM12, CLEC3B, AGR3, IL1RAP and MAMDC4; ADAM12, FGA, AGR3, IL1RAP and ALCAM; PDIA4, PRTN3, PEPD, FAP and SERPINA1; ADAM12, CLEC3B, AGR3, IL1RAP and NCS1; SERPINA1, PKD1, SLAMF8, DCXR and TBCB; ADAM12, MAMDC4, FAP, PRDX1 and ADAMTSL4; TNC, CLEC3B, AGR3, IL1RAP and PRDX1; AREG, PKD1, DCXR, IL1RAP and TNC; FGA, AGR3, SLAMF8, HEG1, and ADAMTSL4; ADAM12, SLAMF8, DCXR, IL1RAP, and TBCB; SERPINA1, ADAM12, IL1RAP, PLXDC2, and DCXR; AREG, MAMDC4, IL1RAP, PLXDC2, and CEACAM5; CEACAM5, AGR3, HEG1, PRDX1, and FGA; ADAM12, FGA, FAP, PRDX1, and NCS1; SERPINA1, AREG, IL1RAP, PLXDC2, and AGR3; PDIA4, CEACAM5, MEGF9, PEPD, and AD AM12; SERPINA1, MAMDC4, IL1RAP, PLXDC2, and NCS1; PDIA4, PEPD, DCXR, IL1RAP, and ALCAM; SERPINA1, SLAMF8, PEPD, DCXR, and MAMDC4; AREG, TNC, PKD1, MAMDC4, and FAP; PDIA4, PKD1, PEPD, DCXR, and ADAMTSL4; PDIA4, MCAM, DCXR, ALCAM, and CEACAM5; SERPINA1, CEACAM5, HEG1, IL1RAP, and PEPD; ADAM12, PDIA4, CD55, FAP, and ALCAM;PDIA4, FGA, PKD1, DCXR, and PEPD; SERPINA1, PDIA4, PKD1, DCXR, and MAMDC4; AREG, ADAM12, HEG1, IL1RAP, and PDIA4; AREG, FGA, HEG1, IL1RAP, and NCS1; ADAM12, TNC, AGR3, IL1RAP, and SERPINA1; CEACAM5, ADAMTSL4, SLAMF8, HEG1, and PDIA4; AREG, ADAM12, PKD1, DCXR, and PRDX1; ADAM12, TNC, AGR3, IL1RAP, and ITIH3; CEACA M5, FGA, PEPD, HEG1 and TNC; PDIA4, ADAMTSL4, PKD1, DCXR and NCS1; FGA, SLAMF8, PEPD, HEG1 and LRG1; PDIA4, PKD1, PEPD, DCXR and ALCAM; PDIA4, TNC, IGFBP2, MCAM and MAMDC4; ADAM12, TNC, AGR3, IL1RAP and CEACAM5; AREG, CEACAM5, HEG1, IL1RAP and PRDX1; ADAM12, CEACAM5, FAP, PRDX1 and ITIH3; PDIA4, TBCB, PKD1, DCXR and ITIH3; AREG, TBCB, PKD1, DCXR and TNC; SERPINA1, SLAMF8, PEPD, DCXR and PDIA4; PDIA4, TNC, PEPD, FAP and CLEC3B; AREG, MAMDC4, IL1RAP, PLXDC2 and CLEC3B; PDIA4, TBCB, PKD1, DCXR and IL17RA; CEACAM5, FGA, PEPD, HEG1 and ADAM12; TNC, AGR3, MAMDC4, IL1RAP and PKD1; PDIA4, TNC, MCAM, DCXR and AGR3; PDIA4, PRTN3, PEPD, FAP and MCAM; PDIA4, TNC, MAMDC4, CD55 and DCXR; AREG, PDIA4, DCXR, ALCAM and PEPD; AREG, TNC, MAMDC4, NCS1 and AGR3; SERPINA1, PDIA4, PKD1, DCXR and IL17RA; ADAM12, FGA, MAMDC4, HEG1 and PEPD; AREG, FGA, HEG1, IL1RAP and DCXR; ADAM12, FGA, AGR3, IL1RAP and PEPD; PDIA4, CEACAM5, PKD1, DCXR and NCS1;CEACAM5, ADAMTSL4, HEG1, PRDX1, and IGFBP2; ADAM12, MAMDC4, FAP, PRDX1, and PDIA4; PDIA4, CEACAM5, PKD1, DCXR, and MAMDC4; ADAM12, TNC, AGR3, IL1RAP, and CLEC3B; SERPINA1, MAMDC4, IL1RAP, PLXDC2, and CEACAM5; AREG, ADAM12, HEG1, IL1RAP, and DCXR; SERPINA1, CEACAM5, IL1RAP, PLXDC2, and NCS1; ADAM12, PDIA4, CD55, FA P and AGR3; PDIA4, TBCB, PEPD, FAP and PRDX1; ADAM12, LRG1, FAP, PRDX1 and PDIA4; PDIA4, CEACAM5, MEGF9, PEPD and SLAMF8; PDIA4, PKD1, DCXR, IL1RAP and FAP; AREG, FGA, PEPD, HEG1 and ADAMTSL4; SERPINA1, TNC, DCXR, PLXDC2 and PDIA4; SERPINA1, MEGF9, PRTN3, IL1RAP and AGR3; PDIA4, IGFBP2, PKD1, DCXR and IL17RA; SERPINA 1, PDIA4, PKD1, DCXR and NCS1; PDIA4, TNC, MCAM, DCXR and NCS1; PDIA4, IGFBP2, PKD1, DCXR and ALCAM; PDIA4, PEPD, DCXR, IL1RAP and FAP; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and LRG1; PDIA4, FAP, DCXR, ALCAM and TBCB; AREG, CEACAM5, HEG1, IL1RAP and AGR3; PDIA4, TNC, ITIH3, PKD1 and TBCB; SERPINA1, AREG, IL1RAP, PLXDC2 and TNC; ADAM12, DCXR, IL1RAP, ALCAM, and MAMDC4; PDIA4, TBCB, PEPD, FAP, and AGR3; PDIA4, FGA, IGFBP2, PKD1, and ITIH3; AREG, TNC, PKD1, MAMDC4, and ALCAM; ADAM12, CEACAM5, DCXR, IL1RAP, and SERPINA1; AREG, MAMDC4, IL1RAP, PLXDC2, and MCAM; SERPINA1, CEACAM5, CLEC3B, PRDX1, and AGR3; SERPINA1, SLAMF8, PEPD, DCXR, and ALCAM;PDIA4, PEPD, HEG1, FAP and CEACAM5; AREG, ADAM12, TNC, NCS1 and PRDX1; CEACAM5, FGA, PEPD, HEG1 and DCXR; AREG, TBCB, PKD1, DCXR and NCS1; SERPINA1, HEG1, IL1RAP, PLXDC2 and PDIA4; ADAM12, FGA, SLAMF8, NCS1 and TBCB; ADAM12, SLAMF8, DCXR, IL1RAP and PDIA4; SERPINA1, PKD1, SLAMF8, DCXR and PEPD; AREG, ADAM12, PDIA4, CD55, and AGR3; PDIA4, PKD1, DCXR, IL1RAP, and ADAMTSL4; ADAM12, PDIA4, CD55, FAP, and TBCB; CEACAM5, AGR3, HEG1, PRDX1, and TBCB; FGA, SLAMF8, PEPD, HEG1, and MAMDC4; SERPINA1, SLAMF8, PEPD, DCXR, and TBCB; SERPINA1, PDIA4, MAMDC4, PLXDC2, and PEPD; PDIA4, FAP, DCXR, ALCAM, and NCS1; PDIA4, IL17RA, DCXR, and ALC AM and NCS1; SERPINA1, TBCB, SLAMF8, PLXDC2 and DCXR; SERPINA1, CEACAM5, CLEC3B, PRDX1 and PDIA4; PDIA4, PEPD, DCXR, IL1RAP and PRDX1; SERPINA1, MEGF9, PRTN3, IL1RAP and PEPD; ADAM12, PDIA4, DCXR, ALCAM and AGR3; CEACAM5, AGR3, SLAMF8, HEG1 and NCS1; ADAM12, MAMDC4, FAP, PRDX1 and ALCAM; AREG, TBCB, PKD1, D CXR and FAP; PDIA4, CEACAM5, PKD1, DCXR and AGR3; SERPINA1, MAMDC4, IL1RAP, PLXDC2 and MCAM; SERPINA1, AREG, PKD1, DCXR and ALCAM; AREG, ADAM12, PKD1, DCXR and ALCAM; AREG, PDIA4, DCXR, ALCAM and AGR3; ADAM12, PDIA4, CD55, FAP and PRDX1; SERPINA1, SLAMF8, DCXR, PLXDC2 and TNC; ADAM12, PDIA4, PKD1, DCXR and AGR3;SERPINA1, MAMDC4, IL1RAP, PLXDC2, and ALCAM; SERPINA1, CEACAM5, FGA, HEG1, and DCXR; SERPINA1, MEGF9, PRTN3, IL1RAP, and TNC; CEACAM5, FGA, HEG1, PRDX1, and PEPD; PDIA4, PEPD, FAP, DCXR, and TNC; PDIA4, FGA, IGFBP2, PKD1, and TBCB; SERPINA1, PDIA4, CEACAM5, HEG1, and ADAM12; AREG, ADAM12, HEG1, IL1RAP, and ITIH3; AD AM12, PDIA4, DCXR, ALCAM, and IGFBP2; AREG, PDIA4, PKD1, DCXR, and PEPD; AREG, ADAM12, HEG1, IL1RAP, and MAMDC4; SERPINA1, CEACAM5, IL1RAP, PLXDC2, and ADAM12; FGA, CLEC3B, MAMDC4, HEG1, and PRDX1; SERPINA1, PDIA4, MAMDC4, PLXDC2, and LRG1; SERPINA1, PDIA4, MAMDC4, PLXDC2, and AGR3; SERPINA1, PDIA4, MAMDC4, PL XDC2 and TBCB; AREG, ADAM12, IL1RAP, PLXDC2 and DCXR; SERPINA1, AREG, FGA, HEG1 and PEPD; SERPINA1, MEGF9, PRTN3, IL1RAP and ALCAM; SERPINA1, PDIA4, PKD1, DCXR and AGR3; ADAM12, MAMDC4, FAP, PRDX1 and DCXR; PDIA4, CEACAM5, PEPD, HEG1 and MAMDC4; PDIA4, CEACAM5, MEGF9, PEPD and AGR3; PDIA4, ITIH3, PEPD, FAP and I L17RA; SERPINA1, AREG, PKD1, DCXR, and PEPD; AREG, ADAM12, HEG1, IL1RAP, and ALCAM; CEACAM5, FGA, PEPD, HEG1, and IGFBP2; PDIA4, CEACAM5, PEPD, HEG1, and TBCB; PDIA4, FGA, PKD1, DCXR, and MAMDC4; PDIA4, CEACAM5, PKD1, DCXR, and PEPD; ADAM12, DCXR, IL1RAP, ALCAM, and CEACAM5; SERPINA1, AREG, IL1RAP, PLXDC2, and NCS1;PDIA4, DCXR, IL1RAP, ALCAM and CLEC3B; SERPINA1, SLAMF8, DCXR, PLXDC2 and LRG1; ADAM12, MAMDC4, FAP, PRDX1 and IGFBP2; CEACAM5, TNC, FGA, HEG1 and MAMDC4; SERPINA1, TNC, DCXR, PLXDC2 and FAP; AREG, CEACAM5, FGA, HEG1 and MEGF9; FGA, AGR3, SLAMF8, HEG1 and FAP; SERPINA1, SLAMF8, DCXR, PLXDC2 and ALCAM; SERPINA1, PKD1, SLAMF8, DCXR, and PDIA4; ADAM12, TBCB, FAP, PRDX1, and ITIH3; PDIA4, CLEC3B, PKD1, DCXR, and ALCAM; PDIA4, MCAM, DCXR, ALCAM, and AGR3; FGA, CLEC3B, MAMDC4, HEG1, and IL17RA; SERPINA1, AREG, IL1RAP, PLXDC2, and ALCAM; PDIA4, FGA, IGFBP2, PKD1, and ALCAM; PDIA4, TBCB, PEPD, FAP, and MCAM; AREG, TBCB, PKD1, DCXR, and PEPD; PDIA4, CEACAM5, PKD1, DCXR, and TNC; SERPINA1, SLAMF8, PEPD, DCXR, and ADAMTSL4; AREG, TNC, PKD1, MAMDC4, and DCXR; PDIA4, CEACAM5, DCXR, ALCAM, and PEPD; SERPINA1, TBCB, SLAMF8, PLXDC2, and TNC; AREG, ADAM12, IL1RAP, PLXDC2, and ALCAM; AREG, PKD1, DCXR, IL1RAP, and TBCB; PDIA4, TNC, MAMDC4, CD55, and ADAM12; PDIA4, PKD 1. PRTN3, PEPD and TBCB; ADAM12, FGA, MAMDC4, HEG1 and FAP; PDIA4, PKD1, PRTN3, PEPD and AGR3; PDIA4, CLEC3B, PKD1, DCXR and MAMDC4; SERPINA1, HEG1, IL1RAP, PLXDC2 and PEPD; ADAM12, PDIA4, PKD1, DCXR and NCS1; FGA, SLAMF8, PEPD, HEG1 and ALCAM; SERPINA1, AREG, IL1RAP, PLXDC2 and TBCB; PDIA4, TBCB, PKD1, DCXR and LRG1;PDIA4, PEPD, DCXR, IL1RAP and NCS1; SERPINA1, MEGF9, PRTN3, IL1RAP and NCS1; ADAM12, FGA, AGR3, IL1RAP and DCXR; AREG, ADAM12, PKD1, DCXR and IL17RA; ADAM12, CEACAM5, DCXR, IL1RAP and FGA; TNC, CLEC3B, AGR3, IL1RAP and FAP; FGA, CLEC3B, MAMDC4, HEG1 and AGR3; AREG, MAMDC4, IL1RAP, PLXDC2 and DCXR; CEACAM5, FGA, PEPD, HEG1, and TBCB; AREG, ADAM12, HEG1, IL1RAP, and PEPD; ADAM12, PDIA4, CD55, FAP, and ITIH3; AREG, PDIA4, CEACAM5, HEG1, and PEPD; PDIA4, ITIH3, PKD1, PEPD, and DCXR; CEACAM5, AGR3, HEG1, PRDX1, and SERPINA1; ADAM12, AGR3, MAMDC4, IL1RAP, and DCXR; AREG, TBCB, PKD1, DCXR, and ADAMTSL4; SERPINA1, PKD1, SLAMF 8. DCXR and ALCAM; ADAM12, FGA, SLAMF8, NCS1 and IL17RA; PDIA4, PKD1, PEPD, DCXR and MCAM; CEACAM5, AGR3, HEG1, PRDX1 and CLEC3B; AREG, TBCB, PKD1, DCXR and AGR3; PDIA4, PRTN3, PEPD, FAP and IL17RA; PDIA4, SLAMF8, MCAM, DCXR and PRDX1; FGA, AGR3, SLAMF8, HEG1 and PDIA4; SERPINA1, PDIA4, CEACAM5, HEG1 and ADAMTSL 4; PDIA4, FAP, DCXR, ALCAM and TNC; AREG, ADAM12, IL1RAP, PLXDC2 and AGR3; SERPINA1, PDIA4, PKD1, DCXR and CLEC3B; PDIA4, ADAMTSL4, PKD1, DCXR and SERPINA1; PDIA4, PKD1, DCXR, IL1RAP and IL17RA; ADAM12, TNC, FAP, PRDX1 and NCS1; SERPINA1, SLAMF8, DCXR, PLXDC2 and AGR3; FGA, CLEC3B, MAMDC4, HEG1 and CEACAM5;ADAM12, CEACAM5, DCXR, IL1RAP, and LRG1; ADAM12, FGA, SLAMF8, NCS1, and SERPINA1; ADAM12, PDIA4, CD55, FAP, and IL17RA; SERPINA1, PEPD, IL1RAP, PLXDC2, and MCAM; PDIA4, PEPD, DCXR, IL1RAP, and MAMDC4; PDIA4, PEPD, DCXR, IL1RAP, and IGFBP2; ADAM12, SLAMF8, DCXR, IL1RAP, and LRG1; AREG, PDIA4, CEACAM5, HEG1, and NCS1 ; PDIA4, TNC, MCAM, DCXR and PRDX1; PDIA4, CEACAM5, PEPD, HEG1 and PRDX1; SERPINA1, CEACAM5, CLEC3B, PRDX1 and IGFBP2; PDIA4, ITIH3, PEPD, FAP and ALCAM; CEACAM5, AGR3, SLAMF8, HEG1 and LRG1; PDIA4, CEACAM5, DCXR, ALCAM and MAMDC4; SERPINA1, PEPD, IL1RAP, PLXDC2 and DCXR; FGA, SLAMF8, PEPD, HEG1 and CLEC3B; A DAM12, DCXR, IL1RAP, ALCAM, and ITIH3; AREG, ADAM12, PKD1, DCXR, and MCAM; PDIA4, SLAMF8, MCAM, DCXR, and FAP; ADAM12, TNC, AGR3, IL1RAP, and TBCB; PDIA4, SLAMF8, MCAM, DCXR, and SERPINA1; PDIA4, FGA, PKD1, DCXR, and TBCB; PDIA4, FGA, PEPD, HEG1, and TNC; CEACAM5, ADAMTSL4, HEG1, PRDX1, and MAMDC4; ADAM12, MAMDC4, and FAP , PRDX1 and CLEC3B; PDIA4, PKD1, PRTN3, PEPD and NCS1; PDIA4, TBCB, PKD1, DCXR and ADAM12; ADAM12, CEACAM5, FGA, HEG1 and DCXR; AREG, ADAM12, FGA, HEG1 and PDIA4; CEACAM5, FGA, HEG1, PRDX1 and SERPINA1; CEACAM5, AGR3, SLAMF8, HEG1 and ADAMTSL4; PDIA4, TNC, MAMDC4, CD55 and NCS1; ADAM12, PEPD, FAP, PRDX1 and PDIA4;FGA, SLAMF8, PEPD, HEG1 and TNC; AREG, PDIA4, PKD1, DCXR and CEACAM5; SERPINA1, AREG, PKD1, DCXR and NCS1; PDIA4, TBCB, PKD1, DCXR and TNC; ADAM12, FGA, AGR3, IL1RAP and CLEC3B; PDIA4, IGFBP2, DCXR, ALCAM and TNC; AREG, ADAM12, HEG1, IL1RAP and PRDX1; PDIA4, CEACAM5, MEGF9, PEPD and NCS1; ADAM12, PDIA4, DCXR, ALCAM and IL17RA; SERPINA1, ADAM12, FAP, PRDX1, and TBCB; PDIA4, CEACAM5, PKD1, DCXR, and FGA; AREG, ADAM12, IL1RAP, PLXDC2, and PDIA4; PDIA4, FGA, PKD1, DCXR, and ASPN; CEACAM5, ADAMTSL4, HEG1, PRDX1, and IL17RA; ADAM12, AGR3, MAMDC4, IL1RAP, and PDIA4; AREG, TNC, MAMDC4, NCS1, and ITIH3; SERPINA1, AREG, FGA, and HEG1 and PDIA4; PDIA4, CEACAM5, PEPD, HEG1, and NCS1; CEACAM5, SLAMF8, PEPD, HEG1, and IGFBP2; SERPINA1, MAMDC4, IL1RAP, PLXDC2, and PDIA4; ADAM12, FGA, SLAMF8, NCS1, and DCXR; PDIA4, PKD1, DCXR, IL1RAP, and PEPD; PDIA4, PEPD, FAP, DCXR, and NCS1; TNC, CLEC3B, AGR3, IL1RAP, and CEACAM5; SERPINA1, ADAM12, FAP, PRDX1, and PDI A4; PDIA4, PKD1, PRTN3, PEPD and PRDX1; SERPINA1, PDIA4, CEACAM5, HEG1 and SLAMF8; ADAM12, FGA, AGR3, IL1RAP and PRDX1; PDIA4, ITIH3, PEPD, FAP and CEACAM5; CEACAM5, FGA, HEG1, PRDX1 and IL17RA; ADAM12, FGA, AGR3, IL1RAP and ADAMTSL4; TNC, AGR3, MAMDC4, IL1RAP and IGFBP2; ADAM12, PDIA4, CD55, FAP and MAMDC4;AREG, ADAM12, PKD1, DCXR and CLEC3B; SERPINA1, PKD1, SLAMF8, DCXR and LRG1; CEACAM5, SLAMF8, PEPD, HEG1 and TNC; AREG, TNC, MAMDC4, NCS1 and MCAM; TNC, AGR3, MAMDC4, IL1RAP and FGA; ADAM12, LRG1, FAP, PRDX1 and DCXR; PDIA4, ADAMTSL4, PKD1, DCXR and AGR3; AREG, TNC, PKD1, MAMDC4 and IGFBP2; ADAM12, TBCB, FAP, PRDX1 and DCXR; AREG, PDIA4, PKD1, DCXR and ALCAM; FGA, TBCB, MAMDC4, HEG1 and SERPINA1; ADAM12, TNC, AGR3, IL1RAP and PDIA4; SERPINA1, MEGF9, PRTN3, IL1RAP and MCAM; PDIA4, ITIH3, PKD1, PEPD and IGFBP2; PDIA4, PEPD, DCXR, IL1RAP and ADAMTSL4; AREG, MAMDC4, IL1RAP, PLXDC2 and ALCAM; ADAM12, DCXR, IL1RAP, AL CAM and ADAMTSL4; PDIA4, CEACAM5, DCXR, ALCAM and NCS1; ADAM12, CEACAM5, DCXR, IL1RAP and PRDX1; CEACAM5, SLAMF8, HEG1, DCXR and AGR3; SERPINA1, PEPD, IL1RAP, PLXDC2 and ITIH3; SERPINA1, HEG1, IL1RAP, PLXDC2 and ALCAM; ADAM12, FGA, FAP, PRDX1 and PDIA4; PDIA4, TNC, MAMDC4, CD55 and TBCB; AREG, FGA, PEPD, H EG1 and MAMDC4; FGA, AGR3, SLAMF8, HEG1 and LRG1; ADAM12, PDIA4, DCXR, ALCAM and MCAM; CEACAM5, SLAMF8, HEG1, DCXR and ALCAM; SERPINA1, CEACAM5, FGA, HEG1 and MCAM; ADAM12, TNC, FAP, PRDX1 and IGFBP2; ADAM12, SLAMF8, DCXR, IL1RAP and MAMDC4; AREG, PDIA4, DCXR, ALCAM and ADAM12; AREG, TBCB, PKD1, DCXR and ALCAM;AREG, MAMDC4, IL1RAP, PLXDC2, and PEPD; AREG, PDIA4, CEACAM5, HEG1, and DCXR; PDIA4, TBCB, PEPD, FAP, and ADAMTSL4; SERPINA1, CLEC3B, IL1RAP, PLXDC2, and DCXR; PDIA4, PKD1, DCXR, IL1RAP, and NCS1; AREG, MAMDC4, IL1RAP, PLXDC2, and PDIA4; SERPINA1, TNC, DCXR, PLXDC2, and AGR3; ADAM12, CLEC3B, AGR3, IL1RAP, and CEACAM5; P DIA4, FGA, PKD1, DCXR, and ADAMTSL4; PDIA4, ITIH3, PKD1, PEPD, and FAP; PDIA4, FGA, PKD1, DCXR, and LRG1; PDIA4, CEACAM5, MEGF9, PEPD, and ALCAM; ADAM12, FGA, MAMDC4, HEG1, and TNC; CEACAM5, FGA, HEG1, PRDX1, and PDIA4; ADAM12, CEACAM5, FAP, PRDX1, and ADAMTSL4; PDIA4, TNC, MCAM, DCXR, and CLEC3B; PDIA4, TNC, MAMDC4, CD55, and F GA; AREG, FGA, HEG1, IL1RAP and FAP; CEACAM5, FGA, PEPD, HEG1 and ALCAM; AREG, MAMDC4, IL1RAP, PLXDC2 and ITIH3; PDIA4, PKD1, PRTN3, PEPD and MAMDC4; PDIA4, TNC, PEPD, FAP and ALCAM; AREG, FGA, PEPD, HEG1 and CEACAM5; CEACAM5, AGR3, HEG1, PRDX1 and ALCAM; SERPINA1, CEACAM5, FGA, HEG1 and ASPN; SERPINA1, CEACAM5, CL EC3B, PRDX1, and MAMDC4; ADAM12, FGA, FAP, PRDX1, and IL17RA; PDIA4, FGA, PKD1, DCXR, and NCS1; AREG, MAMDC4, IL1RAP, PLXDC2, and TNC; PDIA4, DCXR, IL1RAP, ALCAM, and MAMDC4; SERPINA1, CEACAM5, FGA, HEG1, and AGR3; PDIA4, SLAMF8, MCAM, DCXR, and AGR3; AREG, ADAM12, PKD1, DCXR, and SERPINA1; PDIA4, IGFBP2, CD55, MCAM, and DCXR;PDIA4, FGA, PKD1, DCXR and ALCAM; PDIA4, TNC, MAMDC4, CD55 and ADAMTSL4; PDIA4, TNC, IGFBP2, MCAM and ADAMTSL4; PDIA4, IGFBP2, PKD1, DCXR and LRG1; PDIA4, CEACAM5, PKD1, DCXR and LRG1; AREG, ADAM12, PKD1, DCXR and CEACAM5; ADAM12, DCXR, IL1RAP, ALCAM and PRDX1; ADAM12, CLEC3B, AGR3, IL1RAP and ADAMTSL4; PDIA4, PEPD, FAP, DCXR, and AGR3; TNC, AGR3, MAMDC4, IL1RAP, and TBCB; ADAM12, PDIA4, DCXR, ALCAM, and ADAMTSL4; CEACAM5, FGA, PEPD, HEG1, and NCS1; SERPINA1, PDIA4, MAMDC4, PLXDC2, and ALCAM; AREG, PDIA4, CEACAM5, HEG1, and PRDX1; ADAM12, TBCB, FAP, PRDX1, and CLEC3B; PDIA4, PEPD, HEG1, FAP, and PRDX1; TNC, AGR3, MAMDC4, and IL1RA P and PEPD; ADAM12, CEACAM5, FGA, HEG1 and PDIA4; PDIA4, IGFBP2, DCXR, ALCAM and TBCB; CEACAM5, SLAMF8, PEPD, HEG1 and IL17RA; PDIA4, FGA, PEPD, HEG1 and TBCB; ADAM12, FGA, SLAMF8, NCS1 and ITIH3; AREG, TBCB, PKD1, DCXR and PDIA4; PDIA4, PKD1, PRTN3, PEPD and DCXR; PDIA4, PEPD, FAP, DCXR and CLEC3B; PDIA4, SLAMF8, MCA M, DCXR and MAMDC4; AREG, PDIA4, DCXR, ALCAM and TBCB; SERPINA1, HEG1, IL1RAP, PLXDC2 and ITIH3; SERPINA1, ADAM12, FAP, PRDX1 and MAMDC4; ADAM12, PDIA4, DCXR, ALCAM and TBCB; ADAM12, FGA, FAP, PRDX1 and MAMDC4; AREG, PKD1, DCXR, IL1RAP and FAP; ADAM12, PDIA4, PKD1, DCXR and ITIH3; PDIA4, CLEC3B, PKD1, DCXR and AGR3;PDIA4, TNC, ITIH3, PKD1, and MAMDC4; SERPINA1, SLAMF8, PEPD, DCXR, and IL17RA; FGA, TBCB, MAMDC4, HEG1, and AGR3; PDIA4, TNC, PEPD, FAP, and AGR3; SERPINA1, AREG, PKD1, DCXR, and ADAMTSL4; or FGA, AGR3, SLAMF8, HEG1, and SERPINA1 (i.e., the 674 5-marker combinations in italics in Table 7).

[0038] Preferably, the A includes a 6-markers combination, and the 6-markers combination is any six of the Bs.

[0039] Preferably, the 6 markers are combined into b1) and b2):

[0040] b1) the 5-markers combination (preferably any one of the 674 5-markers combinations mentioned above);

[0041] b2) any one of the above B;

[0042] The b2) is different from any one marker in the combination of 5 markers in b1).

[0043] Preferably, the 6 markers combination is: SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7; PDIA4, CEACAM5, PKD1, DCXR, FGA and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4 and ITGA11; SERPINA1, TNC, DCXR, PLXDC2, AGR3 and PCDH7; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PEAR1; CEACAM5, FGA, HEG1, PRDX1, IL17RA and PCDH7; CEACAM5, FGA, PEPD, HEG1, NCS1 and CNTN4; ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CKB; CEACAM5, FGA, PEPD, HEG1, ALCAM and PEAR1; CEACAM5, FGA, PEPD, HEG1, TBCB and NAGPA; AREG, FGA, PEPD, HEG1, CEACAM5 and TINAGL1; SERPINA1, CEACAM5, FGA, HEG1, MCAM and AGR3; CEACAM5, FGA, HEG1, PRDX1, IL17RA and TNC; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and DCXR; AREG, FGA, PEPD, HEG1, CEACAM5, and PDIA4; FGA, AGR3, SLAMF8, HEG1, SERPINA1, and PCDH7; TNC, AGR3, MAMDC4, IL1RAP, FGA, and PRDX1; SERPINA1, TNC, DCXR, PLXDC2, AGR3, and PEAR1; CEACAM5, FGA, PEPD, HEG1, NCS1, and CD58; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and PDIA4; AREG, FGA, PEPD, HEG1, CEACAM5 and AGR3; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and TINAGL1; CEACAM5, FGA, PEPD, HEG1, ALCAM and CKB; CEACAM5, FGA, PEPD, HEG1, ALCAM and CD58; PDIA4, CEACAM5, PKD1, DCXR, FGA and NCS1; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and GDF15; CEACAM5, FGA, HEG1, PRDX1, IL17RA and ITGAV; CEACAM5, FGA, PEPD, HEG1, NCS1 and TBCB;PDIA4, FGA, PKD1, DCXR, ALCAM, and PEAR1; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and ENPP6; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and IGFBP2; CEACAM5, FGA, PEPD, HEG1, ALCAM, and IGFBP2; AREG, FGA, PEPD, HEG1, CEACAM5, and ITGA11; ADAM12, FGA, SLAMF8, NCS1, DCXR, and PEAR1; CEACAM5, FGA, PEPD, HEG1, NCS1, and GDF15; CEACAM 5, FGA, PEPD, HEG1, ALCAM and AGR3; ADAM12, CEACAM5, FGA, HEG1, PDIA4 and COMP; CEACAM5, FGA, PEPD, HEG1, NCS1 and AGR3; CEACAM5, FGA, PEPD, HEG1, ALCAM and ACY1; CEACAM5, FGA, PEPD, HEG1, TNC and PDIA4; AREG, PDIA4, CEACAM5, HEG1, DCXR and PCDH7; FGA, AGR3, SLAMF8, HEG1, LRG1 and PCDH7; FGA, AGR3, SLAMF8, HEG1, SE RPINA1 and PEAR1; CEACAM5, FGA, PEPD, HEG1, ALCAM and ITGA11; AREG, FGA, PEPD, HEG1, CEACAM5 and NAGPA; PDIA4, TNC, MAMDC4, CD55, FGA and CNTN4; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CANT1; CEACAM5, FGA, PEPD, HEG1, NCS1 and PCDH7; AREG, FGA, PEPD, HEG1, CEACAM5 and IGFBP2; SERPINA1, CEACAM5, FGA, HEG1, ASPN and ITGA11; CEACAM5, FGA, HEG1, PRDX1, PDIA4 and CPM; CEACAM5, FGA, HEG1, PRDX1, IL17RA and CPM; SERPINA1, CEACAM5, FGA, HEG1, MCAM and NCS1; FGA, AGR3, SLAMF8, HEG1, SERPINA1 and ITGA11; SERPINA1, CEACAM5, FGA, HEG1, ASPN and CANT1; CEACAM5, FGA, PEPD, HEG1, NCS1 and PEAR1; CEACAM5, FGA, PEPD, HEG1, NCS1 and ACY1;AREG, FGA, PEPD, HEG1, CEACAM5 and PRDX1; ADAM12, CEACAM5, FGA, HEG1, PDIA4 and CANT1; PDIA4, SLAMF8, MCAM, DCXR, AGR3 and PCDH7; CEACAM5, FGA, PEPD, HEG1, ALCAM and CA14; AREG, FGA, PEPD, HEG1, CEACAM5 and NCS1; SERPINA1, CEACAM5, FGA, HEG1, MCAM and CNTN4; AREG, FGA, PEPD, HEG1, CEACAM5 and DCXR; CEACAM5, FGA, PEPD, HEG1, ALCAM, and TBCB; CEACAM5, FGA, HEG1, PRDX1, PDIA4, and ITGA11; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and CNTN4; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and APOA4; PDIA4, CEACAM5, PKD1, DCXR, LRG1, and PCDH7; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and CD58; TNC, AGR3, MAMDC4, IL1RAP, TBCB, and ITGA11; SERPI NA1, CEACAM5, FGA, HEG1, MCAM, and TINAGL1; CEACAM5, SLAMF8, PEPD, HEG1, TNC, and CPM; SERPINA1, CEACAM5, FGA, HEG1, ASPN, and PDIA4; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and ACY1; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and ACY1; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and ITGA11; CEACAM5, FGA, PEPD, HEG1, NCS1, and TINAG L1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and AGR3; PDIA4, TNC, MAMDC4, CD55, ADAMTSL4, and ITGA11; AREG, FGA, PEPD, HEG1, CEACAM5, and CNTN4; PDIA4, FGA, PKD1, DCXR, NCS1, and IGFBP2; CEACAM5, SLAMF8, PEPD, HEG1, TNC, and PDIA4; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, and PEAR1; CEACAM5, FGA, PEPD, HEG1, ALCAM, and NCS1;CEACAM5, FGA, PEPD, HEG1, NCS1 and CD34; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and ITGA11; CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and CNTN4; FGA, TBCB, MAMDC4, HEG1, AGR3 and PRDX1; ADAM12, FGA, FAP, PRDX1, MAMDC4 and CANT1; AREG, PDIA4, CEACAM5, HEG1, PRDX1 and AGR3; CEACAM5, FGA, HEG1, PRDX1, PDIA4 and PEAR1; CEACAM5, SLAMF8, PEPD, HEG1, IL17RA and TINAGL1; SERPINA1, CEACAM5, FGA, HEG1, MCAM and TBCB; AREG, FGA, PEPD, HEG1, CEACAM5 and PCDH7; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CNTN4; TNC, AGR3, MAMDC4, IL1RAP, TBCB and PDIA4; CEACAM5, FGA, PEPD, HEG1, DCXR and ENPP6; SERPINA1, CEACAM5, FGA, HEG1, MCAM and PEAR1; CEACAM5, FGA, HEG1, PRDX1, PDIA4, and CNTN4; CEACAM5, FGA, PEPD, HEG1, NCS1, and CPM; CEACAM5, FGA, PEPD, HEG1, NCS1, and CA14; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and ACY1; TNC, AGR3, MAMDC4, IL1RAP, FGA, and ENPP6; ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, and DCXR; ADAM12, FGA, MAMDC4, HEG1, TNC, and TINAGL1; ADAM12, CEACAM5, FGA, H EG1, PDIA4, and CD58; PDIA4, CEACAM5, PKD1, DCXR, FGA, and CNTN4; PDIA4, TNC, MAMDC4, CD55, FGA, and DCXR; CEACAM5, SLAMF8, PEPD, HEG1, TNC, and CANT1; AREG, FGA, PEPD, HEG1, CEACAM5, and CD34; PDIA4, CLEC3B, PKD1, DCXR, AGR3, and PCDH7; FGA, TBCB, MAMDC4, HEG1, AGR3, and CEACAM5; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and DCXR;AREG, ADAM12, PKD1, DCXR, CEACAM5, and ITGA11; CEACAM5, SLAMF8, HEG1, DCXR, ALCAM, and TBCB; CEACAM5, FGA, HEG1, PRDX1, PEPD, and CFP; CEACAM5, FGA, PEPD, HEG1, ALCAM, and TINAGL1; AREG, PDIA4, DCXR, ALCAM, ADAM12, and PEPD; AREG, FGA, PEPD, HEG1, CEACAM5, and TBCB; CEACAM5, FGA, PEPD, HEG1, ALCAM, and GDF15; F GA, AGR3, SLAMF8, HEG1, SERPINA1 and DCXR; SERPINA1, CEACAM5, FGA, HEG1, ASPN and PCDH7; SERPINA1, TNC, DCXR, PLXDC2, AGR3 and IGFBP2; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PRDX1; AREG, FGA, PEPD, HEG1, CEACAM5 and COMP; CEACAM5, FGA, PEPD, HEG1, NCS1 and APOA4; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and TBCB; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and PPY; CEACAM5, FGA, PEPD, HEG1, ALCAM, and PRDX1; TNC, AGR3, MAMDC4, IL1RAP, FGA, and PEAR1; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and PCDH7; PDIA4, TNC, MAMDC4, CD55, TBCB, and CPM; PDIA4, CEACAM5, PKD1, DCXR, FGA, and PCDH7; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and TINA GL1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and TBCB; AREG, FGA, PEPD, HEG1, CEACAM5, and CA14; TNC, AGR3, MAMDC4, IL1RAP, FGA, and GDF15; CEACAM5, FGA, PEPD, HEG1, TBCB, and CFP; CEACAM5, FGA, HEG1, PRDX1, PDIA4, and PCDH7; PDIA4, PKD1, DCXR, IL1RAP, NCS1, and CEACAM5; SERPINA1, CEACAM5, FGA, HEG1, ASPN, and CNTN4;AREG, ADAM12, PKD1, DCXR, CEACAM5 and NAGPA; ADAM12, FGA, AGR3, IL1RAP, PRDX1 and CPM; CEACAM5, FGA, HEG1, PRDX1, IL17RA and TINAGL1; ADAM12, FGA, AGR3 , IL1RAP, ADAMTSL4 and ITGA11; CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and PCDH7; CEACAM5, FGA, PEPD, HEG1, NCS1 and PRDX1; TNC, AGR3, MAMDC4, IL1RAP, FGA and CN TN4; AREG, FGA, PEPD, HEG1, CEACAM5, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and CNTN4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and DCXR; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, and SPINT1; CEACAM5, FGA, PEPD, HEG1, NCS1, and IL17RA; CEACAM5, SLAMF8, HEG1, DCXR, ALCAM, and AGR3; PDIA4, CEACAM5, PKD1, DCXR, FGA, and GD F15; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and TNC; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and CANT1; ADAM12, TNC, FAP, PRDX1, IGFBP2, and CNTN4; AREG, PDIA4, CEACAM5, HEG1, DCXR, and ITGAV; PDIA4, FGA, PKD1, DCXR, ALCAM, and CPM; SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8, and MFGE8; ADAM12, FGA, MAMDC4, HEG1, TNC, and CO MP; PDIA4, CEACAM5, PKD1, DCXR, FGA, and AGR3; AREG, PDIA4, CEACAM5, HEG1, DCXR, and PEAR1; AREG, ADAM12, PKD1, DCXR, CEACAM5, and CANT1; CEACAM5, FGA, HEG1, PRDX1, PDIA4, and ACY1; AREG, TBCB, PKD1, DCXR, ALCAM, and ITGA11; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and PCDH7; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and CANT1;PDIA4, TNC, PEPD, FAP, ALCAM, and AGR3; PDIA4, CEACAM5, MEGF9, PEPD, ALCAM, and TINAGL1; PDIA4, FGA, PKD1, DCXR, LRG1, and ITGA11; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and CA14; TNC, AGR3, MAMDC4, IL1RAP, FGA, and PCDH7; PDIA4, TNC, MAMDC4, CD55, FGA, and CANT1; AREG, ADAM12, PKD1, DCXR, CEACAM5, and PEAR1; CEACAM5, SL AMF8, HEG1, DCXR, AGR3 and CD55; PDIA4, ITIH3, PKD1, PEPD, FAP and CEACAM5; SERPINA1, CEACAM5, FGA, HEG1, ASPN and COMP; CEACAM5, FGA, HEG1, PRDX1, PDIA4 and MAMDC4; TNC, AGR3, MAMDC4, IL1RAP, IGFBP2 and PDIA4; CEACAM5, FGA, PEPD, HEG1, TNC and TBCB; TNC, AGR3, MAMDC4, IL1RAP, FGA and TBCB; CEACAM5, FGA, PEPD, HEG1, NCS1 and ITGAV; CEACAM5, SLAMF8, PEPD, HEG1, TNC and ITGA11; TNC, AGR3, MAMDC4, IL1RAP, FGA and TINAGL1; CEACAM5, FGA, PEPD, HEG1, ALCAM and PCDH7; PDIA4, FGA, PKD1, DCXR, ADAMTSL4 and PCDH7; AREG, FGA, HEG1, IL1RAP, FAP and ITGA11; PDIA4, IGFBP2, DCXR, ALCAM, TNC and TBCB; SERPINA1, PDIA4, CEACAM5, HEG 1. SLAMF8 and CFP; ADAM12, PDIA4, DCXR, ALCAM, TBCB and PCDH7; CEACAM5, FGA, PEPD, HEG1, TBCB and MZB1; CEACAM5, FGA, PEPD, HEG1, ALCAM and PPY; AREG, FGA, PEPD, HEG1, CEACAM5 and CKB; FGA, AGR3, SLAMF8, HEG1, LRG1 and GDF15; CEACAM5, FGA, HEG1, PRDX1, IL17RA and COMP; CEACAM5, FGA, HEG1, PRDX1, PDIA4 and TINAGL1;ADAM12, FGA, AGR3, IL1RAP, PRDX1, and CFP; SERPINA1, CEACAM5, FGA, HEG1, ASPN, and TBCB; AREG, PDIA4, CEACAM5, HEG1, DCXR, and CD58; FGA, AGR3, SLAMF8, HEG1, SERPINA1, and GDF15; PDIA4, TNC, PEPD, FAP, AGR3, and CANT1; CEACAM5, SLAMF8, PEPD, HEG1, TNC, and CD34; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and TINAGL1; TNC, AGR 3, MAMDC4, IL1RAP, PEPD and TINAGL1; AREG, FGA, PEPD, HEG1, CEACAM5 and ACY1; FGA, AGR3, SLAMF8, HEG1, LRG1 and CPM; CEACAM5, FGA, HEG1, PRDX1, PEPD and MZB1; SERPINA1, CEACAM5, FGA, HEG1, MCAM and CA14; CEACAM5, FGA, PEPD, HEG1, ALCAM and PDIA4; AREG, FGA, PEPD, HEG1, CEACAM5 and CDH23; SERPINA1, SLAMF8, PEPD, D CXR, IL17RA and PCDH7; CEACAM5, FGA, HEG1, PRDX1, IL17RA and CD34; PDIA4, CEACAM5, PKD1, DCXR, FGA and ACY1; CEACAM5, FGA, PEPD, HEG1, ALCAM and CNTN4; ADAM12, FGA, FAP, PRDX1, MAMDC4 and CNTN4; ADAM12, FGA, FAP, PRDX1, MAMDC4 and ITGA11; CEACAM5, SLAMF8, HEG1, DCXR, AGR3 and IL17RA; FGA, AGR3, SLAMF8, HEG1, CE ACAM5 and PKD1; FGA, AGR3, SLAMF8, HEG1, LRG1 and CKB; PDIA4, CEACAM5, PKD1, DCXR, FGA and ITGA11; AREG, ADAM12, PKD1, DCXR, CEACAM5 and TNC; CEACAM5, SLAMF8, PEPD, HEG1, TNC and DCXR; AREG, ADAM12, PKD1, DCXR, CEACAM5 and PEPD; AREG, FGA, PEPD, HEG1, CEACAM5 and CFP; SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and CPM;CEACAM5, FGA, PEPD, HEG1, NCS1, and ITGA11; SERPINA1, CEACAM5, FGA, HEG1, ASPN, and TINAGL1; PDIA4, CEACAM5, PKD1, DCXR, LRG1, and PEAR1; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and DCXR; CEACAM5, FGA, PEPD, HEG1, NCS1, and TNC; SERPINA1, CEACAM5, FGA, HEG1, ASPN, and PEAR1; ADAM12, PDIA4, DCXR, ALCAM, TBCB, and AGR 3; AREG, ADAM12, PKD1, DCXR, SERPINA1 and TNC; SERPINA1, AREG, PKD1, DCXR, ADAMTSL4 and PCDH7; ADAM12, FGA, FAP, PRDX1, MAMDC4 and CEACAM5; CEACAM5, AGR3, HEG1, PRDX1, ALCAM and NCS1; TNC, CLEC3B, AGR3, IL1RAP, CEACAM5 and CPM; PDIA4, TNC, MAMDC4, CD55, ADAMTSL4 and CPM; AREG, FGA, PEPD, HEG1, CEACAM5 and C PM; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and NCS1; CEACAM5, FGA, PEPD, HEG1, ALCAM, and ITGAV; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and MAMDC4; CEACAM5, FGA, HEG1, PRDX1, PDIA4, and CANT1; CEACAM5, FGA, PEPD, HEG1, DCXR, and CLEC3B; PDIA4, PKD1, DCXR, IL1RAP, PEPD, and ENPP6; SERPINA1, AREG, FGA, HEG1, PDIA4, and DP P4; SERPINA1, CLEC3B, IL1RAP, PLXDC2, DCXR, and TNC; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and CD58; PDIA4, CEACAM5, PKD1, DCXR, LRG1, and TBCB; CEACAM5, SLAMF8, PEPD, HEG1, TNC, and AGR3; FGA, TBCB, MAMDC4, HEG1, AGR3, and PEAR1; ADAM12, FGA, FAP, PRDX1, PDIA4, and TBCB; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, and GDF15;SERPINA1, CEACAM5, FGA, HEG1, ASPN, and TNC; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and CD58; PDIA4, PEPD, FAP, DCXR, CLEC3B, and PEAR1; CEACAM5, FGA, PEPD, HEG1, TNC, and NAGPA; FGA, CLEC3B, MAMDC4, HEG1, CEACAM5, and PCDH7; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and CANT1; SERPINA1, CEACAM5, FGA, HEG1, ASPN, and ACY1; CEA CAM5, FGA, HEG1, PRDX1, IL17RA and AGR3; PDIA4, TNC, MAMDC4, CD55, FGA and TBCB; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2 and CNTN4; CEACAM5, SLAMF8, HEG1, DCXR, ALCAM and CANT1; CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA and CNTN4; AREG, FGA, PEPD, HEG1, MAMDC4 and NCS1; FGA, AGR3, SLAMF8, HEG1, LRG1 and ACY1; FGA, AGR 3. SLAMF8, HEG1, CEACAM5, and PDIA4; PDIA4, FGA, PKD1, DCXR, NCS1, and CPM; AREG, ADAM12, PKD1, DCXR, CEACAM5, and CD34; AREG, TNC, PKD1, MAMDC4, IGFBP2, and ACY1; PDIA4, FGA, PKD1, DCXR, ALCAM, and TBCB; FGA, TBCB, MAMDC4, HEG1, AGR3, and ITGA11; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and KHK; FGA, TBCB, MAMDC4, HEG1, AGR3 and CNTN4; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, and CEACAM5; PDIA4, CEACAM5, MEGF9, PEPD, NCS1, and AGR3; AREG, TNC, MAMDC4, NCS1, MCAM, and TBCB; ADAM12, DCXR, IL1RAP, ALCAM, PRDX1, and PEPD; AREG, ADAM12, PKD1, DCXR, CEACAM5, and CPM; AREG, FGA, PEPD, HEG1, CEACAM5, and CANT1; AREG, PKD1, DCXR, IL1RAP, FAP, and PEPD;AREG, FGA, PEPD, HEG1, MAMDC4, and CEACAM5; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and TNC; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and KHK; PDIA4, CEACAM5, DCXR, ALCAM, NCS1, and PEAR1; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, and TINAGL1; CEACAM5, AGR3, HEG1, PRDX1, FGA, and PCDH7; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and CKB ; TNC, AGR3, MAMDC4, IL1RAP, TBCB and COMP; SERPINA1, CEACAM5, FGA, HEG1, ASPN and CPM; CEACAM5, FGA, HEG1, PRDX1, IL17RA and KHK; PDIA4, PKD1, DCXR, IL1RAP, PEPD and ITGA11; CEACAM5, FGA, PEPD, HEG1, ALCAM and APOA4; PDIA4, TNC, MAMDC4, CD55, TBCB and AGR3; SERPINA1, CEACAM5, FGA, HEG1, MCAM and CKB; PDIA4, FG A, PKD1, DCXR, ASPN and PCDH7; TNC, AGR3, MAMDC4, IL1RAP, IGFBP2 and CNTN4; AREG, PKD1, DCXR, IL1RAP, FAP and ITGA11; CEACAM5, FGA, PEPD, HEG1, DCXR and SSC4D; CEACAM5, FGA, PEPD, HEG1, NCS1 and CANT1; AREG, TNC, PKD1, MAMDC4, IGFBP2 and CANT1; ADAM12, TNC, AGR3, IL1RAP, PDIA4 and CNTN4; PDIA4, PEPD, FAP, DCXR, NCS1 and PCDH7; CEACAM5, FGA, HEG1, PRDX1, PDIA4 and AGR3; TNC, AGR3, MAMDC4, IL1RAP, PDIA4 and CA14; ADAM12, CEACAM5, DCXR, IL1RAP, FGA and PCDH7; CEACAM5, SLAMF8, PEPD, HEG1, TNC and ITGAV; CEACAM5, FGA, PEPD, HEG1, AGR3 and TBCB; AREG, FGA, PEPD, HEG1, CEACAM5 and ENPP6; AREG, FGA, PEPD, HEG1, MAMDC4 and CNTN4;PDIA4, CEACAM5, MEGF9, PEPD, ALCAM, and PCDH7; PDIA4, IGFBP2, DCXR, ALCAM, TNC, and PCDH7; PDIA4, FGA, PKD1, DCXR, NCS1, and GDF15; FGA, AGR3, SLAMF8, HEG1, LRG1, and TINAGL1; PDIA4, TNC, ITIH3, PKD1, MAMDC4, and CANT1; CEACAM5, SLAMF8, PEPD, HEG1, IL17RA, and CANT1; ADAM12, FGA, SLAMF8, NCS1, DCXR, and CNTN4; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and IGFBP2; CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA, and ITGA11; ADAM12, FGA, AGR3, IL1RAP, PRDX1, and PCDH7; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and CPM; PDIA4, FGA, PKD1, DCXR, ASPN, and TBCB; SERPINA1, ADAM12, FAP, PRDX1, TBCB, and AGR3; ADAM12, CEACAM5, FGA, HEG1, PDI A4 and CPM; CEACAM5, FGA, PEPD, HEG1, ALCAM and CPM; AREG, FGA, HEG1, IL1RAP, FAP and CKB; CEACAM5, TNC, FGA, HEG1, DCXR and IL1R2; CEACAM5, FGA, HEG1, PRDX1, IL17RA and CA14; AREG, FGA, PEPD, HEG1, CEACAM5 and ITGAV; AREG, TBCB, PKD1, DCXR, NCS1 and PEPD; PDIA4, FGA, PKD1, DCXR, ALCAM and IGFBP2; PDIA4, CEACA M5, PKD1, DCXR, LRG1, and IGFBP2; SERPINA1, PKD1, SLAMF8, DCXR, LRG1, and CANT1; SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8, and CNTN4; AREG, ADAM12, PKD1, DCXR, CEACAM5, and AGR3; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, and SSC4D; PDIA4, FGA, PKD1, DCXR, ASPN, and ITGA11; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, and PCDH7;CEACAM5, FGA, HEG1, PRDX1, PDIA4, and CD55; PDIA4, FGA, PKD1, DCXR, NCS1, and PEAR1; CEACAM5, SLAMF8, PEPD, HEG1, IL17RA, and DDC; PDIA4, TNC, PEPD, FAP, AGR3, and CEACAM5; AREG, FGA, PEPD, HEG1, CEACAM5, and CD58; CEACAM5, FGA, PEPD, HEG1, ALCAM, and IL17RA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and GDF15; FGA, TBCB , MAMDC4, HEG1, AGR3 and TINAGL1; SERPINA1, TNC, DCXR, PLXDC2, AGR3 and CANT1; CEACAM5, TNC, FGA, HEG1, DCXR and TBCB; ADAM12, TNC, FAP, PRDX1, IGFBP2 and CPM; CEACAM5, FGA, HEG1, PRDX1, PDIA4 and ITGAV; CEACAM5, FGA, HEG1, PRDX1, IL17RA and TBCB; AREG, FGA, HEG1, IL1RAP, FAP and MAMDC4; PDIA4, SLAMF8, MCAM , DCXR, AGR3 and IGFBP2; ADAM12, CLEC3B, AGR3, IL1RAP, CEACAM5 and CA14; SERPINA1, CEACAM5, FGA, HEG1, ASPN and ITGAV; PDIA4, CEACAM5, MEGF9, PEPD, NCS1 and TBCB; PDIA4, FGA, PKD1, DCXR, ADAMTSL4 and CNTN4; AREG, TBCB, PKD1, DCXR, ALCAM and HPGDS; PDIA4, PKD1, DCXR, IL1RAP, NCS1 and SSC4D; ADAM12, FGA, MAM DC4, HEG1, TNC, and CD34; PDIA4, CEACAM5, PKD1, DCXR, LRG1, and CKB; PDIA4, FGA, PKD1, DCXR, ALCAM, and PCDH7; PDIA4, CEACAM5, DCXR, ALCAM, NCS1, and TNC; PDIA4, CEACAM5, PKD1, DCXR, FGA, and MCAM; PDIA4, TNC, MAMDC4, CD55, FGA, and AGR3; PDIA4, ITIH3, PKD1, PEPD, FAP, and CANT1; PDIA4, FGA, PKD1, DCXR, NCS1, and CNTN4;ADAM12, PDIA4, DCXR, ALCAM, ADAMTSL4, and CNTN4; AREG, MAMDC4, IL1RAP, PLXDC2, TNC, and ITGA11; SERPINA1, TNC, DCXR, PLXDC2, AGR3, and PDIA4; ADAM12, PDIA4, CD55, FAP, MAMDC4, and CEACAM5; AREG, PDIA4, PKD1, DCXR, ALCAM, and DDC; ADAM12, PDIA4, DCXR, ALCAM, TBCB, and CEACAM5; CEACAM5, FGA, HEG1, PRDX1, PD IA4 and TBCB; PDIA4, FGA, PKD1, DCXR, NCS1 and TBCB; PDIA4, CEACAM5, DCXR, ALCAM, NCS1 and PRDX1; AREG, ADAM12, IL1RAP, PLXDC2, PDIA4 and CD58; AREG, PDIA4, PKD1, DCXR, ALCAM and DPP4; PDIA4, CEACAM5, PKD1, DCXR, FGA and TBCB; SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and AGR3; CEACAM5, AGR3, HEG1, PRDX1, ALCAM and DCXR; CEACAM5, SLAMF8, PEPD, HEG1, IL17RA, and COMP; PDIA4, FGA, PKD1, DCXR, ADAMTSL4, and CKB; AREG, TNC, MAMDC4, NCS1, ITIH3, and CD58; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and CKB; PDIA4, CEACAM5, PKD1, DCXR, LRG1, and CNTN4; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, and ACY1; ADAM12, FGA, MAMDC4, HEG1, TNC, and ITG AV; AREG, PDIA4, PKD1, DCXR, ALCAM, and NCS1; CEACAM5, ADAMTSL4, HEG1, PRDX1, IL17RA, and AGR3; PDIA4, CEACAM5, PKD1, DCXR, FGA, and CFP; CEACAM5, FGA, HEG1, PRDX1, PDIA4, and NCS1; FGA, TBCB, MAMDC4, HEG1, SERPINA1, and CNTN4; PDIA4, CEACAM5, PKD1, DCXR, FGA, and CKB; ADAM12, FGA, SLAMF8, NCS1, DCXR, and PCDH7;CEACAM5, FGA, PEPD, HEG1, NCS1 and ITIH3; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and CPM; PDIA4, IGFBP2, PKD1, DCXR, LRG1 and AGR3; PDIA4, CEACAM5, PKD1, D CXR, FGA and SERPINA1; SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8 and AGR3; FGA, AGR3, SLAMF8, HEG1, SERPINA1 and PDIA4; CEACAM5, SLAMF8, PEPD, HEG1, IL17 RA and ITGA11; ADAM12, DCXR, IL1RAP, ALCAM, PRDX1 and DPP4; SERPINA1, CEACAM5, FGA, HEG1, AGR3 and COMP; SERPINA1, PKD1, SLAMF8, DCXR, LRG1 and CEACAM5; PDIA4, CEACAM5, MEGF9, PEPD, DCXR and FAP; CEACAM5, SLAMF8, PEPD, HEG1, TNC and CNTN4; ADAM12, CEACAM5, FGA, HEG1, PDIA4 and IL17RA; ADAM12, CEACAM5, F AP, PRDX1, ADAMTSL4, and CNTN4; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, and PCDH7; SERPINA1, SLAMF8, PEPD, DCXR, IL17RA, and ENPP6; CEACAM5, FGA, HEG1, PRDX1, IL17RA, and PDIA4; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and TBCB; ADAM12, FGA, FAP, PRDX1, MAMDC4, and PDIA4; ADAM12, CEACAM5, DCXR, IL1RAP, PRDX1, and APO A4; CEACAM5, SLAMF8, PEPD, HEG1, TNC, and TBCB; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and PPY; CEACAM5, FGA, PEPD, HEG1, ALCAM, and CD34; CEACAM5, SLAMF8, PEPD, HEG1, IL17RA, and TNC; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and TNC; SERPINA1, TNC, DCXR, PLXDC2, AGR3, and ACY1; AREG, TNC, PKD1, MAMDC4, IGFBP2, and CD58;SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8, and ACY1; CEACAM5, FGA, HEG1, PRDX1, PEPD, and TBCB; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and ITGAV; ADAM12, CEACAM5, FGA, HEG1, PDIA4, and CD34; PDIA4, FGA, PKD1, DCXR, LRG1, and IGFBP2; TNC, AGR3, MAMDC4, IL1RAP, IGFBP2, and CPM; TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, and AC Y1;AREG, FGA, PEPD, HEG1, MAMDC4 and CANT1; PDIA4, CEACAM5, PKD1, DCXR, LRG1 and CA14;AREG, TBCB, PKD1, DCXR, ALCAM and CNTN4; PDIA4, FGA, PEPD, HEG1, TBCB and NCS1; PDIA4, ADAMTSL4, PKD1, DCXR, AGR3 and CANT1; PDIA4, CEACAM5, PEPD, HEG1, NCS1 and COMP; PDIA4, FGA, PEPD, HEG1, TBCB and ITGA11; SERPINA1, P KD1, SLAMF8, DCXR, LRG1, and PEAR1; AREG, PKD1, SLAMF8, DCXR, TBCB, and LILRA4; SERPINA1, PDIA4, CEACAM5, HEG1, SLAMF8, and TINAGL1; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and CANT1; ADAM12, FGA, MAMDC4, HEG1, TNC, and CEACAM5; AREG, MAMDC4, IL1RAP, PLXDC2, TNC, and PDIA4; ADAM12, CEACAM5, FGA, HEG1, PKD1, and PD IA4; SERPINA1, AREG, FGA, HEG1, PDIA4, and ITGA11; FGA, AGR3, SLAMF8, HEG1, LRG1, and NCS1; SERPINA1, CEACAM5, FGA, HEG1, AGR3, and APOA4; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, and C1QTNF1; TNC, AGR3, MAMDC4, IL1RAP, TBCB, and CNTN4; ADAM12, PDIA4, DCXR, ALCAM, TBCB, and CPM; PDIA4, FGA, PKD1, DCXR, LRG1, and PEAR1;AREG, FGA, PEPD, HEG1, CEACAM5, and GDF15; AREG, ADAM12, IL1RAP, PLXDC2, PDIA4, and NCS1; FGA, TBCB, MAMDC4, HEG1, SERPINA1, and COMP; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and ITGA11; SERPINA1, CEACAM5, FGA, HEG1, MCAM, and CDH23; ADAM12, FGA, AG R3, IL1RAP, PRDX1, and CKB; ADAM12, AGR3, MAMDC4, IL1RAP, PDIA4, and TINAGL1; ADAM12, FGA, MAMDC4, HEG1, TNC, and AGR3; PDIA4, CEACAM5, MEGF9, PEPD, ALCAM, and CKB; PDIA4, IGFBP2, DCXR, ALCAM, TNC, and PRDX1; CEACAM5, ADAMTSL4, HEG1, PRDX1, and IL17 RA and CANT1; TNC, AGR3, MAMDC4, IL1RAP, PEPD and ITGA11; SERPINA1, CEACAM5, FGA, HEG1, MCAM and MAMDC4; CEACAM5, FGA, HEG1, PRDX1, IL17RA and NCS1; CEACAM5, TNC, FGA, HEG1, MAMDC4 and IGFBP2; AREG, PDIA4, CEACAM5, HEG1, PRDX1 and C1QTNF1; CEA CAM5, SLAMF8, PEPD, HEG1, IGFBP2, and CFP; CEACAM5, FGA, PEPD, HEG1, TNC, and PCDH7; FGA, AGR3, SLAMF8, HEG1, LRG1, and CNTN4; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, and PDIA4; or SERPINA1, MEGF9, PRTN3, IL1RAP, MCAM, and RPGR (i.e., the 475 6-marker combinations in Table 8).

[0044] Preferably, the A comprises a combination of 7 markers, and the combination of 7 markers is any seven of the combinations in B.

[0045] Preferably, the 7 markers are combined into c1) and c2):

[0046] c1) the 6-markers combination (preferably any one of the 475 6-markers combinations mentioned above);

[0047] c2) any one of the above B;

[0048] The c2) is different from any one of the markers in the combination of 6 markers in c1).

[0049] Preferably, the 7 markers combination is: ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and LILRA4; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MC AM;AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and ADAMTSL4;ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and PEAR1;ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and PEAR1;AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and LILRA4;ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and PDIA4;ADAM12, CEACAM5, FGA, HE G1, PDIA4, KHK, and ADAMTSL4; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5, and NCS1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and COMP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, and IL17RA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and CLEC3B; ADAM12, CEACAM5 ACAM5, DCXR, IL1RAP, FGA, PCDH7, and MCAM; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and FAP; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5, and MCAM; ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, DCXR, and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and HEG1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR, and AGR3;ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, and ADAMTSL4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, and FAP; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and PDIA4; ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM, and NCS1; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and NCS 1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and COMP; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and NCS1; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5, and FAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and FAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB, and NCS1; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and MC AM;AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD, and LRCH4;AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and HEG1;ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and NCS1;ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and PEAR1;AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and HEG1;AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD, and NCS1;ARE G, ADAM12, PKD1, DCXR, CEACAM5, CPM and ADAMTSL4; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and MAMDC4; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and NCS1; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and IL17RA; AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and NCS1; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and SSC4D;ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and MZB1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, and IL17RA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, COMP, and LILRA4; ADAM12, CEACAM5, FGA, HEG1, PDIA 4. DCXR and NCS1; TNC, AGR3, MAMDC4, IL1RAP, FGA, PRDX1 and COMP; AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and NCS1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and NCS1; ADAM12, CEACAM5, DCXR, IL1RAP, PRDX1, APOA4 and COMP; ADAM12, SLAMF8, DCXR, IL1RAP , MAMDC4, CEACAM5 and LRCH4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and C1QTNF1; AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and PEAR1; SERPINA1, CEACAM5, FGA, HEG1, MCAM, TNC and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and MCAM; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and LILRA4; SERPINA1, CEA CAM5, FGA, HEG1, AGR3, CANT1, and IL17RA; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and PDIA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34, and PRDX1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB, and CLEC3B; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and ADAMTSL4; CEACAM5, FGA, PEPD, HEG1, ALCAM, PCDH7, and RAB37;AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and HEG1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, and NCS1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1, and AGR3; ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5, and AGR3; AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and FAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM, and IL17RA; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and AGR3; TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, CPM and MCAM; PDIA4, PKD1, DCXR, IL1RAP, NCS1, CEACAM5 and RAB37; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB and PEAR1; AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and HEG1; ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM and HEG1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and ITGA11; AREG, FGA, PEPD, HEG1, CEACAM5, DCXR, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, and NCS1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, and ADAMTSL4; CEACAM5, FGA, PEPD, HEG1, ALCAM, CA14, and DPP4; SERPINA1, CEACAM5, FGA, HEG1, MCAM, PEAR1, and PCDH7; AREG, AD AM12, PKD1, DCXR, CEACAM5, PEAR1, and IL17RA; ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5, and CDH23; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD, and ADAMTSL4; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and PRDX1; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and PRDX1; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, IL17RA, and CDH23;ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5, and PEAR1; AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34, and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD, and AGR3; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and HEG1; TNC, AGR3, MAMDC4, IL1RAP, PEPD, TINAGL1, and HEG1; ADAM12, FGA, AGR3, IL1RAP, PRDX1 , CPM and MCAM; ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR and LILRA4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and NCS1; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and FAP; FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5 and IL17RA; ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and FAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and PCDH7; AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and HEG1; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5 and RTN4R; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and LRCH4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and IL17RA; ADAM12, C EACAM5, FGA, HEG1, PDIA4, ITGA11, and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and CDH23; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and CPM; AREG, FGA, PEPD, HEG1, CEACAM5, NCS1, and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and IL17RA; CEACAM5, FGA, PEPD, HEG1, NCS1, PEAR1, and LILRA4;AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD, and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and IL17RA; CEACAM5, FGA, PEPD, HEG1, ALCAM, TINAGL1, and PEAR1; AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and ADAMTSL4; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5 , CD34 and MCAM; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7 and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and FAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and PRDX1; SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1 and MCAM; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and C1QTNF1; ADAM12, CEACAM5, FGA, HE G1, PDIA4, DCXR and MCAM; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and AGR3; CEACAM5, FGA, PEPD, HEG1, NCS1, AGR3 and IL1RAP; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and C1QTNF1; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and MAMDC4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and LRCH4; ADAM12, SLAMF8, DCX R, IL1RAP, MAMDC4, CEACAM5, and PDIA4; CEACAM5, AGR3, HEG1, PRDX1, ALCAM, NCS1, and IL17RA; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, and ADAMTSL4; AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA, and PDIA4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and PCDH7; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB, and IL17RA;AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and LILRA4; FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5, and MCAM; CEACAM5, FGA, HEG1, PRDX1, IL17RA, CNTN4, and IL1RAP; TNC, AGR3, MAMDC4, IL1RAP, PDIA4, CA14, and HEG1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and NCS1; SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1, and NCS1; C EACAM5, FGA, PEPD, HEG1, NCS1, CANT1, and FAP; CEACAM5, FGA, PEPD, HEG1, NCS1, CANT1, and CDH23; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and IL17RA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and ADAMTSL4; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5, and ADAMTSL4; CEACAM5, FGA, PEPD, HEG1, ALCAM, AGR3, and I L17RA; PDIA4, PKD1, DCXR, IL1RAP, NCS1, CEACAM5, and COMP; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and RAB37; ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5, and LRCH4; CEACAM5, FGA, PEPD, HEG1, ALCAM, TBCB, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and PEAR1; TNC, AGR3, MAMDC4, IL1RAP, FGA, TBCB, and M CAM; CEACAM5, FGA, PEPD, HEG1, ALCAM, CKB, and IL17RA; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and CLEC3B; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and COMP; ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM, and MZB1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and MCAM; CEACAM5, FGA, PEPD, HEG1, ALCAM, GDF15, and IL1RAP;ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34, and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD, and CLEC3B; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and PLXDC2; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and ESM1; AREG, FGA, PEPD, HEG1, CEACAM5, TINAGL1, and RAB 37; CEACAM5, SLAMF8, PEPD, HEG1, TNC, CPM and PEAR1; PDIA4, CEACAM5, MEGF9, PEPD, NCS1, AGR3 and RAB37; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and RAB37; CEACAM5, FGA, PEPD, HEG1, NCS1, ACY1 and IL1RAP; CEACAM5, FGA, PEPD, HEG1, ALCAM, AGR3 and CDH23; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and IL1RAP; AD AM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, and MZB1; CEACAM5, FGA, PEPD, HEG1, ALCAM, GDF15, and PEAR1; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, PEAR1, and RAB37; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and GNAS; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, and NCS1; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and RAB37; AR EG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and PEAR1; SERPINA1, CEACAM5, FGA, HEG1, ASPN, CANT1, and AGR3; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and MZB1; ADAM12, FGA, MAMDC4, HEG1, TNC, COMP, and PRDX1; AREG, PDIA4, CEACAM5, HEG1, DCXR, PCDH7, and CDH23; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and CDH23;AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA, and PRDX1; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, and HEG1; ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4, and MAMDC4; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and RAB37; PDIA4, CEACAM5, PKD1, DCXR, FGA, PEAR1, and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and AGR3; CEACAM5, FGA, PEPD, HEG1, NCS1, ITGA11, and IL1RAP; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and CKB; CEACAM5, FGA, PEPD, HEG1, NCS1, GDF15, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and FAP; PDIA4, CEACAM5, PKD1, DCXR, FGA, ITGA11, and CDH23; ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, and LRC H4; AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and FAP; AREG, FGA, PEPD, HEG1, CEACAM5, TBCB and ADAMTSL4; AREG, FGA, PEPD, HEG1, CEACAM5, TINAGL1 and IL17RA ; ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and MCAM; ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and MCAM; AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA and NCS1; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, and NCS1; SERPINA1, CEACAM5, FGA, HEG1, AGR3, ACY1, and CDH23; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58, and ADAMTSL4; TNC, AGR3, MAMDC4, IL1RAP, FGA, PCDH7, and NCS1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, and IL17RA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, and FAP;AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and NCS1; AREG, FGA, PEPD, HEG1, CEACAM5, TBCB, and LILRA4; AREG, ADAM12, PKD1, DCXR, CEACAM5, ITGA11, and MCAM; ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and MZB1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, IL17RA, and C1QTNF1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, COM P and MZB1; CEACAM5, FGA, HEG1, PRDX1, PDIA4, PEAR1 and RAB37; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and LILRA4; ADAM12, FGA, FAP, PRDX1, MAMDC4, CEACAM5 and IL1RAP; CEACAM5, FGA, PEPD, HEG1, NCS1, CANT1 and IL1RAP; CEACAM5, FGA, PEPD, HEG1, ALCAM, PDIA4 and AGR3; CEACAM5, FGA, PEPD, HEG1, NCS1, AGR3 and MCAM; ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, ITGA11, and MCAM; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, and NCS1; AREG, FGA, PEPD, HEG1, CEACAM5, CKB, and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, CANT1, and PCDH7; SERPINA1, CEACAM5, FGA, HEG1, AGR3, TNC, and PEAR1; AREG, FGA, PEPD, HEG1, CEACAM5, NCS1, and PCDH7 ;CEACAM5, FGA, PEPD, HEG1, ALCAM, ACY1 and MCAM;CEACAM5, FGA, PEPD, HEG1, TNC, TBCB and NCS1;AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and CLEC3B;SERPINA1, CEACAM5, FGA, HEG1, AGR3, CNTN4 and IL1RAP;SERPINA1, CEACAM5, FGA, HEG1, AGR3, PDIA4 and IL17RA;TNC, AGR3, MAMDC4, IL1RAP, FGA, ENPP6 and COMP;CEACAM5, FGA, PEPD, HEG1, ALCAM, PCDH7, and PEAR1; CEACAM5, FGA, PEPD, HEG1, TNC, TBCB, and C1QTNF1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, and CDH23; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and ADAMTSL4 ;ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK and RAB37;ADAM12, TNC, AGR3, IL1RAP, PDIA4, CNTN4 and PEAR1; TNC, CLEC3B, AGR3, IL1RAP, CEACAM5, CPM and COMP;ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and C1QTNF1; CEACAM5, FGA, HEG1, PRDX1, PDIA4, ACY1 and AGR3; CEACAM5, FGA, PEPD, HEG1, NCS1, CD58 and CLEC3B; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58, and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and LILRA4; FGA, TBCB, MAMDC4, HEG1, AGR3, CEACAM5, and COMP; SERPINA1, CEACAM5, FGA, HEG1, AGR3, PEAR1, and PCDH7; ADAM12, SLAMF8, DCXR, IL1RAP, MAMDC4, CEACAM5, and COMP; S ERPINA1, CEACAM5, FGA, HEG1, MCAM, NCS1, and AGR3; PDIA4, CEACAM5, PKD1, DCXR, FGA, AGR3, and IL17RA; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and ITGA11; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and MAMDC4; FGA, AGR3, SLAMF8, HEG1, CEACAM5, PDIA4, and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, PDIA4, and IL17RA;AREG, PDIA4, CEACAM5, HEG1, DCXR, PEAR1, and PCDH7; CEACAM5, FGA, PEPD, HEG1, TNC, PDIA4, and IL17RA; AREG, ADAM12, PKD1, DCXR, CEACAM5, NAGPA, and LILRA4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, and PCDH7; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, and ADAMTSL4; ADAM12, FGA, AGR3, IL1RAP, ADAMTSL4, ITGA 11 and HEG1; AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC and CFP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CD58 and FAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, CPM and HEG1; TNC, AGR3, MAMDC4, IL1RAP, TBCB, PDIA4 and MCAM; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7 and LILRA4; CEACAM5, SLAMF8, HEG1, DCXR, AGR3, GDF15 and IL1RA P; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and SERPINA1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, and MAMDC4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, and MZB1; TNC, AGR3, MAMDC4, IL1RAP, TBCB, COMP, and HEG1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CKB, and COMP; SERPINA1, CEACAM5, FGA, HEG1, MCAM, TNC, and CDH23 ;ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1 and AGR3;ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4 and PRDX1;ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB and LRCH4;ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11 and NCS1;TNC, AGR3, MAMDC4, IL1RAP, FGA, TBCB and HEG1;AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and RAB37;AREG, FGA, PEPD, HEG1, CEACAM5, ITGA11 and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, CD34 and AGR3; AREG, FGA, PEPD , HEG1, CEACAM5, PCDH7 and FAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TINAGL1 and NCS1; PDIA4, CEACAM5, MEGF9, PEPD, NCS 1. AGR3 and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1 and CDH23; CEACAM5, FGA, PEPD, HEG1, TBCB, MZB1 and IL1RAP; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEPD and COMP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4 and LILRA4; SERPINA1, CE ACAM5, FGA, HEG1, MCAM, AGR3 and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3 and FAP; ADAM12, CEACAM5, FGA, HEG1 , PDIA4, TINAGL1 and CDH23; CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4 and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7 and ESM1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, DCXR, and IL17RA; ADAM12, FGA, AGR3, IL1RAP, PRDX1, CPM, and PEAR1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, and RTN4R; or AREG, ADAM12, PKD1, DCXR, CEACAM5, TNC, and APOA4 (i.e., the 301 7-marker combinations in Table 9).

[0050] Preferably, the A includes an 8-marker combination, and the 8-marker combination is any eight of the Bs.

[0051] Preferably, the 8 markers are combined into d1) and d2):

[0052] d1) the 7-markers combination (preferably any one of the 301 7-markers combinations mentioned above);

[0053] d2) any one of the above B;

[0054] The d2) is different from any one of the markers in the 7 markers combination in d1).

[0055] Preferably, the 8 markers combination is: ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and LRCH4; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, SERPINA1 and PLXDC2; ADAM12, FGA, AGR3, IL1RAP, PR DX1, PCDH7, HEG1 and DCXR; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and HPGDS; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, NCS1 and C1QTNF1; ADAM1 2. CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and CLEC3B; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and SLAMF8; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAM DC4, CDH23 and IL1RAP; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, LRCH4 and MCAM; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and ALCAM; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, SERPINA1 and HPGDS; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, HEG1 and MCAM; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4, and PKD1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP, and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM, and IL1RAP; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1, and CEACAM5; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP, and PEPD;ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, HEG1 and PKD1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, COMP and UPB1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, PCDH7 and IL1RAP; CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and KHK; ADAM12, CEACAM 5, FGA, HEG1, PDIA4, PCDH7, FAP and ALCAM; ADAM12, CEACAM5, FGA, HEG1, PDIA4, ITGA11, PCDH7 and C1QTNF1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, PDIA4 and PLXDC2; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CDH23 and IGFBP2; AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, PEAR1 and IGFBP2; ADAM12, CEACAM5, FGA, H EG1, PDIA4, MAMDC4, IL17RA and IGFBP2; AREG, FGA, PEPD, HEG1, CEACAM5, CKB, IL1RAP and SERPINA1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and PKD1; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1 and ASPN; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and CLEC3B; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and RAB37 interact with NAGPA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and CDH23 interact with CLEC3B; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and CPM interact with IGFBP2; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and FAP interact with PKD1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, and PCDH7 interact with UPB1; AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, and ESM1 interact with CANT1;ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and ALCAM; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, HEG1 and CLEC3B; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and SSBP1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, MCAM and PCDH7; ADAM12, CEACAM5, FGA, HEG1, PDIA4, MAMDC4, FAP and IL1RAP; ADAM12, CEACA M5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and UPB1; ADAM12, FGA, AGR3, IL1RAP, PRDX1, PCDH7, ADAMTSL4 and CFP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and IGFBP2; CEACAM5, SLAMF8, PEPD, HEG1, IGFBP2, TBCB, PEAR1 and CANT1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and KHK; ADAM12, CEACAM5, FGA, HEG1 , PDIA4, PCDH7, NCS1 and TBCB; CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and SSC4D; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and SSBP1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CANT1, AGR3 and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ESM1 and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and LRCH4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and FAP and LRCH4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, and CDH23 and IL1RAP; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and PDIA4 and MFGE8; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, and RTN4R and CLEC3B; AREG, FGA, PEPD, HEG1, CEACAM5, PCDH7, and PEAR1 and KRT19;ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, C1QTNF1 and PEPD; AREG, ADAM12, PKD1, DCXR, CEACAM5, CANT1, RAB37 and PCDH7; AREG, FGA, PEPD, HEG1, CEACA M5, PCDH7, ESM1 and SERPINA1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, PCDH7 and PEPD; ADAM12, CEACAM5, FGA, HEG1, PDIA4, KHK, MAMDC4 and IL1RAP; AD AM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, LRCH4 and MFGE8; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and SSC4D; CEACAM5, SLAMF8, PEPD, HEG1, TNC , PDIA4, IL1RAP and IL17RA; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, NCS1 and CANT1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and CLEC3B; AD AM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, FAP and DCXR; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and MZB1; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, ADAMTSL4 and LRCH4; ADAM12, CEACAM5, FGA, HEG1, PDIA4, TBCB, PCDH7 and FAP; AREG, FGA, PEPD, HEG1, CEACAM5, CANT1, PCDH7 and SERPINA1; ADA M12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, RAB37 and IGFBP2; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, ITGA11 and PCDH7; ADAM12, CEACAM5, FGA, HEG1, PDIA4, AGR3, FAP and IL1RAP; ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, PEAR1 and IGFBP2; ADAM12, CEACAM5, FGA, HEG1, PDIA4, CNTN4, MAMDC4 and IL1RAP;or ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CPM and C1QTNF1 (i.e., 83 8-marker combinations in Table 10). ;

[0056] Preferably, the A also includes at least one of E, the union of the E and the A (the aforementioned A not including E) is the B, and the E and the A (the aforementioned A not including E) have no intersection (for example: the A (the aforementioned A not including E) includes SERPINA1, then E is B that only does not include SERPINA1 (that is, the union of E and SERPINA1 is B); the A (the aforementioned A not including E) includes AREG, then E is B that only does not include AREG).

[0057] Preferably, the test sample of the product is selected from at least one of body fluids, tissues, cells, and excretions of the subject to be tested; more preferably, it is body fluid.

[0058] Preferably, the body fluid comprises at least one of blood, lymph, pleural effusion, cerebrospinal fluid, joint fluid, ascites, saliva, lymph, and body fluid; more preferably, it is blood.

[0059] Preferably, the tissue comprises intestinal mucosal tissue.

[0060] Preferably, the blood includes at least one of serum, plasma, dried blood spots, and whole blood; more preferably, it is serum.

[0061] Preferably, the excrement comprises at least one of urine, feces, and tears.

[0062] Preferably, the test sample is selected from the serum of the subject to be tested.

[0063] Preferably, the subject to be tested includes mammals, such as humans, non-human primates (such as gorillas and apes), rodents (such as rats, mice, and guinea pigs), pets (such as cats and dogs), and livestock (such as horses, cows, sheep, pigs, and rabbits).

[0064] Preferably, the subject to be tested comprises a human.

[0065] Preferably, the substance for detecting a marker comprises a substance for quantitatively detecting a marker.

[0066] Preferably, the substance for detecting a marker includes a substance for detecting a marker at a gene level and / or a protein level.

[0067] Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance technology, immuno-PCR technology, and biotin-avidin technology.

[0068] Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunocoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation analysis, flow cytometry fluorescence resolution, and single molecule detection technology; further preferably, enzyme-linked immunosorbent assay; and further preferably, double antibody sandwich method.

[0069] Preferably, the substance for detecting the marker is selected from one or more of: a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer.

[0070] Preferably, the substance specific for the marker comprises any one of h1) to h4):

[0071] h1) an antibody that specifically binds to the marker;

[0072] h2) a ligand protein or polypeptide that specifically binds to the marker;

[0073] h3) non-protein compounds that specifically recognize markers;

[0074] h4) Nucleic acid aptamers that specifically recognize markers.

[0075] Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody.

[0076] Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system.

[0077] Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma, for example, the markers may be phospholipids disclosed in CN102680597A.

[0078] Preferably, the product further comprises auxiliary detection reagents for gene expression levels, and the auxiliary detection reagents for gene expression levels include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance.

[0079] Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance.

[0080] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; more preferably, it is colorectal advanced adenoma.

[0081] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further preferably, it includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0082] The second aspect of the present invention provides a marker combination, which comprises at least two of the B described in the first aspect of the present invention, and can be 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105 , 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, or 75 kind of species.

[0083] Preferably, the marker combination comprises any 2, 3, 4, 5, 6, 7, or 8 of the Bs.

[0084] Preferably, the marker combination is a 2-markers combination, a 3-markers combination, a 4-markers combination, a 5-markers combination, a 6-markers combination, a 7-markers combination or an 8-markers combination in the first aspect of the present invention.

[0085] Preferably, the marker combination is used to distinguish colorectal cancer from colorectal adenoma.

[0086] Preferably, the marker combination is derived from at least one of body fluids, tissues, cells, and excretions of the subject to be tested; more preferably, body fluids.

[0087] Preferably, the subject to be detected, body fluid, tissue, cell, or excrement is the subject to be detected, body fluid, tissue, cell, or excrement in the first aspect of the present invention.

[0088] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; more preferably, it is colorectal advanced adenoma.

[0089] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further preferably, it includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0090] The third aspect of the present invention is to provide a product comprising substances for detecting the marker combination of the second aspect of the present invention.

[0091] Preferably, the product is used to differentiate colorectal cancer from colorectal adenoma.

[0092] Preferably, the substance for detecting the marker combination comprises a substance for quantitatively detecting the marker combination.

[0093] Preferably, the substance for detecting the marker combination comprises a substance for detecting the marker combination at the gene level and / or protein level.

[0094] Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance technology, immuno-PCR technology, and biotin-avidin technology.

[0095] Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunocoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation analysis, flow cytometry fluorescence resolution, and single molecule detection technology; further preferably, enzyme-linked immunosorbent assay; and further preferably, double antibody sandwich method.

[0096] Preferably, the substance for detecting the marker combination is selected from one or more of: a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer.

[0097] Preferably, the substance specific for the marker comprises any one of h1) to h4):

[0098] h1) an antibody that specifically binds to the marker;

[0099] h2) a ligand protein or polypeptide that specifically binds to the marker;

[0100] h3) non-protein compounds that specifically recognize markers;

[0101] h4) Nucleic acid aptamers that specifically recognize markers.

[0102] Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody.

[0103] Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system.

[0104] Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma, for example, the markers may be phospholipids disclosed in CN102680597A.

[0105] Preferably, the product further comprises auxiliary detection reagents for gene expression levels, and the auxiliary detection reagents for gene expression levels include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance.

[0106] Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance.

[0107] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; more preferably, it is colorectal advanced adenoma.

[0108] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further preferably, it includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0109] The fourth aspect of the present invention is to provide a method for constructing a model, which comprises the step of constructing a model using the markers in the first aspect of the present invention.

[0110] Preferably, the method comprises the step of model building using the marker combination according to the second aspect of the present invention.

[0111] Preferably, the model is used to differentiate between colorectal cancer and colorectal adenoma.

[0112] Preferably, the algorithm for constructing the model includes at least one of logarithmic regression, linear discriminant analysis, eigengene linear discriminant analysis, support vector machine, random forest (RandomRorest), recursive partitioning tree, XGBoost, ShrunkenCentroids, StepAIC, Kth-NearestNeighbor, Boosting, neural network, Bayesian network, and hidden Markov model; further preferably, it includes at least one of random forest (RandomRorest) and XGBoost.

[0113] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; more preferably, it is colorectal advanced adenoma.

[0114] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further preferably, it includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0115] A fifth aspect of the present invention is to provide a device or system comprising:

[0116] Detection module: used to detect the content, activity and / or expression of the marker in the first aspect of the present invention in the test sample; and

[0117] Analysis module: used to input the data acquired by the detection module into the model constructed according to the construction method of the fourth aspect of the present invention for analysis.

[0118] Preferably, the device or system is used to differentiate between colorectal cancer and colorectal adenoma.

[0119] Preferably, the detection module is used to detect the content, activity and / or expression level of the marker combination according to the second aspect of the present invention in a test sample.

[0120] Preferably, the test sample is the test sample in the first aspect of the present invention.

[0121] Preferably, the device or system further comprises: an output module for outputting information according to the analysis results obtained by the analysis module.

[0122] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; more preferably, it is colorectal advanced adenoma.

[0123] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further preferably, it includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0124] A sixth aspect of the present invention provides a computer device, comprising a memory and a processor, wherein the memory stores a program, and when the processor executes the program, it implements any one of the following methods i1)-i2):

[0125] i1) The method for constructing the model according to the fourth aspect of the present invention;

[0126] i2)

[0127] S1: obtaining the content, activity and / or expression of the marker in the first aspect of the present invention in the test sample; and

[0128] S2: Input the data acquired in S1 into the model constructed according to the construction method of the fourth aspect of the present invention for analysis.

[0129] Preferably, S1 in i2) is to obtain the content, activity and / or expression level of the marker combination in the second aspect of the present invention in the test sample.

[0130] Preferably, the test sample is the test sample in the first aspect of the present invention.

[0131] Preferably, i2) further includes the following step: outputting information based on the obtained analysis results.

[0132] The seventh aspect of the present invention provides a computer-storable medium, wherein the computer-readable storage medium includes a stored computer program; wherein, when the computer program is running, the computer-readable storage medium is controlled to implement any one of methods i1)-i2) in the sixth aspect of the present invention.

[0133] The eighth aspect of the present invention provides a method for distinguishing colorectal cancer from colorectal adenoma, comprising the step of detecting the content, expression level and / or activity of the marker in the first aspect of the present invention in a test sample.

[0134] Preferably, the method comprises the step of detecting the content, expression level and / or activity of the marker combination in the second aspect of the present invention in the test sample.

[0135] Preferably, the test sample is the test sample in the first aspect of the present invention.

[0136] Preferably, the product of the first aspect of the present invention is used to detect the content, expression and / or activity of the marker of the first aspect of the present invention in a test sample.

[0137] Preferably, the product of the third aspect of the present invention is used to detect the content, expression level and / or activity of the marker combination of the second aspect of the present invention in a test sample.

[0138] Preferably, the method further comprises the step of inputting the data on the content, expression level and / or activity of the marker in the first aspect of the present invention or the combination of markers in the second aspect of the present invention in the obtained test sample into the model constructed according to the construction method of the fourth aspect of the present invention for analysis.

[0139] Preferably, the method further comprises the step of: outputting information according to the obtained analysis results.

[0140] Preferably, the colorectal adenoma comprises colorectal advanced adenoma and / or colorectal non-advanced adenoma; more preferably, it is colorectal advanced adenoma.

[0141] Preferably, the colorectal cancer includes early colorectal cancer (stage I and stage II) and / or late colorectal cancer (stage III and stage IV); further preferably, it includes early colorectal cancer (stage I and stage II) and late colorectal cancer (stage III and stage IV).

[0142] The beneficial effects of the present invention are:

[0143] The present invention discloses for the first time ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA11, ITGAV, ITIH3, KHK, KRT19, LILRA4 , LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, and UPB1 are used as markers for distinguishing colorectal cancer from colorectal adenoma. The distinction between colorectal cancer and colorectal adenoma can be achieved by detecting the content, expression level and / or activity of the above markers. BRIEF DESCRIPTION OF THE DRAWINGS

[0144] Figure 1 shows the AUC comparison results of some single-marker RandomForest models and XGBboost models.

[0145] FIG2 is a ROC curve diagram of some 2-markers combinations (SERPINA1 and IL17RA; AREG and HEG1).

[0146] Figure 3 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 2-markers combinations.

[0147] FIG4 is a graph showing ROC curves of some 3-marker combinations (AREG, PKD1, and DCXR; SERPINA1, IL17RA, and PLXDC2).

[0148] Figure 5 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 3-markers combinations.

[0149] FIG6 is a graph showing ROC curves of some 4-marker combinations (CEACAM5, FGA, AREG and HEG1; SERPINA1, ADAM12, FAP and PRDX1).

[0150] Figure 7 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 4-markers combinations.

[0151] FIG8 is a graph showing ROC curves of some 5-marker combinations (ADAM12, AGR3, MAMDC4, IL1RAP and TNC; CEACAM5, TNC, FGA, HEG1 and DCXR).

[0152] Figure 9 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 5-markers combinations.

[0153] FIG10 is a graph showing ROC curves of some 6-marker combinations (SERPINA1, CEACAM5, FGA, HEG1, AGR3, and PCDH7; PDIA4, CEACAM5, PKD1, DCXR, FGA, and PEAR1).

[0154] Figure 11 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 6-markers combinations.

[0155] Figure 12 is a ROC curve diagram of some 7-marker combinations (ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4); wherein, A is the combination of ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1, B is the combination of ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4, and the combination of AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4.

[0156] Figure 13 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 7-markers combinations.

[0157] Figure 14 is a ROC curve diagram of some 8-marker combinations (ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4 and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19; CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN); wherein, A is the combination of ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4 and IL1RAP; and the combination of AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19; B is the combination of CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN.

[0158] Figure 15 is a graph showing the AUC comparison between the RandomForest model and the XGBboost model for some 8-markers combinations. DETAILED DESCRIPTION

[0159] The present invention is further described in detail below through specific examples.

[0160] It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0161] The experimental methods in the following examples, where specific conditions are not specified, were generally performed under conventional conditions or the conditions recommended by the manufacturers. The materials and reagents used in these examples were commercially available unless otherwise specified.

[0162] The information of the proteins involved in the following examples is shown in Table 1.

[0163] Table 1 Protein information

[0164] Note: ENSG_Name is the gene name included in the Ensembl database; UNIPROT_SWISSPROT_ACC_Name is the protein name included in the Swiss-Prot sub-library of the UniProt protein database.

[0165] Example 1 Markers for distinguishing colorectal cancer from colorectal adenoma

[0166] 1. Clinical Sample Collection

[0167] In this example, 139 patients diagnosed with colorectal cancer and 39 patients diagnosed with advanced polyps were collected in the hospital. Fresh blood samples were collected before surgery in the hospital, and the protein expression levels in the blood were detected by the protein detection olink platform as markers for modeling and prediction. According to the clinical progression of the patient's disease, the patient group was divided into two groups: 139 cases of colorectal cancer (60 cases in the early stage group and 79 cases in the late stage group) and 39 cases in the colorectal advanced adenoma group. All patients with colorectal cancer and colorectal advanced adenoma were newly diagnosed diseases, and had no other serious diseases and cancers. They had not received surgery or other treatments at the time of sampling. The age range of the colorectal cancer group in the experimental group was 28-83 years old, with an average age of 57.6 years old and a male-to-female ratio of 85:54; the age range of the colorectal advanced adenoma group in the experimental group was 21-84 years old, with an average age of 55.2 years old and a male-to-female ratio of 28:11.

[0168] Sample inclusion criteria:

[0169] Inclusion criteria for the experimental group: (1) patients with confirmed preoperative advanced colorectal adenoma, colon cancer, or rectal cancer; (2) aged 18-80 years, regardless of gender; (3) no history of malignant tumors in other parts of the body; (4) no previous treatment with any other form of anti-tumor therapy before resection; (5) no history of blood transfusion in the past three years.

[0170] Sample exclusion criteria: (1) patients diagnosed with colorectal cancer who have completed surgical treatment or received radiotherapy, chemotherapy, and targeted drug treatment; (2) patients with other non-colorectal cancer tumors, or patients with colorectal metastasis from other tumors.

[0171] Clinical manifestations: 1) In the experimental group (patients with colorectal cancer), pathological examination showed the presence of cancer cells. Some patients had bloody stools, colorectal cramps, anemia, weakness and fatigue.

[0172] 2) Control group (patients with advanced adenomas): adenomas that met one or more of the following criteria: a) diameter >10 mm; b) villous components; c) severe dysplasia or high-grade intraepithelial neoplasia. Some patients experienced bloody stools, colorectal cramping, anemia, weakness, and fatigue.

[0173] In this example, the experimental and control groups were patients who visited the Sixth Affiliated Hospital of Sun Yat-sen University between April and August 2023 and were recruited in strict accordance with the above inclusion criteria. A total of 139 patients diagnosed with colorectal cancer and 39 patients diagnosed with advanced colorectal adenomas were recruited. All specimen collections were approved by the Institutional Review Board of the Sixth Affiliated Hospital of Sun Yat-sen University with signed informed consent from the subjects' families.

[0174] 2. Blood Sample Processing

[0175] 5 mL of peripheral venous blood was collected from the patients and healthy controls using EDTA anticoagulant purple-top tubes, centrifuged for 10 minutes, and the upper plasma was collected and stored vertically in a -80°C refrigerator.

[0176] 3. Protein Detection

[0177] In this example, the inventors performed plasma proteomic testing on 178 plasma samples using the proximity extension technology PEA (Proximity Extension Assay) platform. Specifically, in the test, 3072 protein-specific antibodies were individually labeled with unique PEA oligonucleotide probes. Each antibody was labeled with two independent and complementary sequences. These bound antibodies were mixed into eight independent 384-well plates, each of which included three protein replicates for inter-plate quality control. During the test, 178 samples were randomly distributed on three different 96-well plates and incubated overnight at 4°C with antibodies labeled with PEA probes. After the immune reaction, the extension and pre-amplification mixture was added to the incubated samples for PCR amplification at room temperature. The PCR amplification products were then mixed before adding the individual sample index sequence, followed by a second PCR amplification. After sample mixing, the generated library was magnetic bead purified and quality controlled on a Bioanalyzer. Finally, sequencing was performed using an Illumina NovaSeq 6000 instrument, using two S1 flow cells with a read length of 2 × 50 bases. Counts of known barcode sequences were then converted to normalized protein expression units (NPX) through a quality control and normalization process, resulting in a total of 2,884 proteins being quantified.

[0178] 4. Construction of a protein marker screening model to distinguish colorectal cancer from colorectal adenoma

[0179] The inventors used the XGBoost machine learning method to evaluate potential proteins that can distinguish colorectal adenoma from colorectal cancer. To avoid the bias of sample selection on machine learning modeling, 100 random modeling runs were performed using the Bootstrap method. In each modeling run, 70% (125 cases) of 39 samples of colorectal advanced adenoma and 139 samples of colorectal cancer were selected as the training set (for screening single markers and the construction of models for marker combinations), and the remaining 30% (53 cases) were used as the test set (for verifying the diagnostic efficacy of single markers and marker combinations screened out from the training set).

[0180] (1) The independent predictive ability of each protein in distinguishing colorectal adenoma from colorectal cancer was evaluated by AUC (area under the curve), sensitivity, and specificity. The mean and confidence interval were calculated 100 times. The predictive efficacy of the proteins was ranked, and proteins with AUC greater than 0.7 were screened out.

[0181] (2) The XGBoost machine learning algorithm with no restriction on the number of proteins was used to build a model, and a model with high classification accuracy was screened out. The weight and frequency of each protein in the model were statistically analyzed, thereby identifying four key proteins, AREG, ADAM12, CEACAM5, and SERPINA1, for use in predictive model construction.

[0182] (3) Among the 2884 proteins, the XGBoost machine learning method was used to evaluate the combination of each protein with one of AREG, ADAM12, CEACAM5, and SERPINA1. The AUC, sensitivity, and specificity were evaluated, and protein combinations with an AUC greater than 0.80 were selected.

[0183] After the above three steps, the proteins obtained in each step were combined to obtain 75 markers: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP 2. IL17RA, IL1R2, IL1RAP, ITGA11, ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, P CDH7, PDIA4, PEAR1, PEPD, PKD1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D , TBCB, TINAGL1, TNC, UPB1; among them, 64 proteins had significant differences, as shown in Table 2 (wherein, in Table 2: p.adj is the t-test difference-corrected P value, Mean_AP is the average expression value of the protein after standardization in colorectal adenoma, Mean_CRC is the average expression value of the protein after standardization in colorectal cancer, -LogFC is the difference fold of the average expression value between the two groups of samples (mean_CRC-mean_AP; when -LogFC is greater than 0, it indicates that the protein is highly expressed in colorectal adenocarcinoma patients; when -LogFC is less than 0, it indicates that the protein is highly expressed in colorectal cancer patients. The prediction efficacy AUC values ​​of the 75 proteins ranged from 0.553 to 0.7448, of which 64 proteins had significantly different prediction efficacy AUC values ​​ranging from 0.553 to 0.7448, and 34 proteins had prediction efficacy AUC values ​​greater than 0.65, as shown in Table 3 (wherein, Mean_AUC in Table 3 represents the average AUC of the protein combination in the XGBoost machine learning model for 100 training classifications, sd_AUC represents the standard deviation of the AUC of the 100 training classifications, and Median_AUC represents the median AUC of the 100 training classifications, the same below). It can be seen that the above 75 markers can be used to distinguish colorectal cancer from colorectal adenoma.

[0184] Table 2 64 proteins with significant differences in the training set

[0185] Table 3 34 proteins with prediction efficiency AUC greater than 0.65 in the test set

[0186] Furthermore, in order to verify the accuracy and stability of the above-selected markers, the inventors used the RandomForest machine learning method to perform modeling and prediction analysis on the 10 markers with better performance selected above. The modeling method is as follows: 70% (125 cases) of 39 samples of colorectal advanced adenoma and 139 samples of colorectal cancer were randomly selected as training sets, and the remaining 30% (53 cases) were used as test sets. The model was trained 100 times, and then the average value of the AUC of the 100 models was statistically compared with that of XGBboost. The results are shown in Figure 1: The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close; indicating the interchangeability of the model algorithm in the implementation scheme.

[0187] Among the 75 protein markers mentioned above, the combination marker examples are as follows. Combinations of, but not limited to, 2, 3, 4, 5, 6, 7, and 8 proteins are used, and the AUC, sensitivity, and specificity of each combination are evaluated using the XGBoost machine learning method. The Random Forest machine learning method is used to further verify the combinations with the best results, as follows:

[0188] 2-marker combinations: These are combinations of any two of the 75 markers mentioned above, totaling 2775 combinations, such as SERPINA1 and IL17RA; AREG and HEG1; CLEC3B and SERPINA1; etc. The predictive efficacy AUC values ​​of these 2775 2-marker combinations range from 0.57 to 0.8169 (due to the large number of combinations, the AUC values ​​of the 2-marker combinations are not listed one by one; only the AUC value range of the 2775 2-marker combinations is given to demonstrate the diagnostic efficacy of the above 2775 2-marker combinations). Among them, some 2-marker combinations with AUC greater than 0.80 are shown in Table 4, and the ROC curves of some 2-marker combinations (SERPINA1 and IL17RA; AREG and HEG1) are shown in Figure 2. It can be seen that the above 2775 2-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0189] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 3. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0190] Table 4. Some 2-marker combinations with prediction effectiveness AUC greater than 0.80 in the test set

[0191] 3-marker combination: Based on the results of 2-markers, proteins whose expression levels in combination with other proteins were greater than 0.7 were selected, totaling 33 proteins: ADAM12, ADAMTSL4, AGR3, ALCAM, AREG, ASPN, CD34, CD55, CEACAM5, CLEC3B, DCXR, FAP, FGA, HEG1, IGFBP2, IL17RA, IL1RAP, ITIH3, LRG1, MAMDC4, MCAM, MEGF9, NCS1, P DIA4, PEPD, PKD1, PLXDC2, PRDX1, PRTN3, SERPINA1, SLAMF8, TBCB, TNC; that is, any three combinations of the above 33 markers, a total of 5456 combinations, such as AREG, PKD1 and DCXR; CEACAM5, FGA and HEG1; AREG, ADAM12 and NCS1; etc.; the predictive efficacy AUC values ​​of these 5456 3-marker combinations ranged from 0.637 to 0.8664 (given by Due to the large number of combinations, the AUC values ​​of the 3-marker combinations are not listed one by one. Only the range values ​​of the AUC values ​​of 5456 3-marker combinations are given to demonstrate the diagnostic effect of the above 5456 3-marker combinations); among them, some 3-marker combinations with AUC greater than or equal to 0.83 are shown in Table 5 (wherein, Mean_AUC represents the average AUC of 100 training classifications of the protein combination in the XGBoost machine learning model, sd_AUC is the standard deviation of the AUC of 100 training classifications, Median_AUC is the median of the AUC of 100 training classifications, specificity is the average specificity of 100 training classifications, sensitivity is the average sensitivity of 100 training classifications, accuracy is the average correct rate of 100 training classifications, PPV is the positive predictive value, and NPV is the negative predictive value, the same below). The ROC curves of some 3-marker combinations (AREG, PKD1 and DCXR; SERPINA1, IL17RA and PLXDC2) are shown in Figure 4. It can be seen that the above 5456 3-markers combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0192] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 5. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0193] Table 5 Some 3-marker combinations with prediction effectiveness AUC greater than or equal to 0.83 in the test set

[0194] 4-marker combinations: any combination of four of the above 33 markers, totaling 40,920 combinations, such as: CEACAM5, FGA, PEPD and HEG1; CEACAM5, FGA, TBCB and HEG1; CEACAM5, FGA, AGR3 and HEG1, etc. The predictive efficacy AUC values ​​of these 40,920 4-marker combinations range from 0.66 to 0.9036. (Due to the large number of combinations, the AUC values ​​of the 4-marker combinations are not listed one by one.) Only the range of AUC values ​​for the 40,920 4-marker combinations is given to demonstrate the diagnostic effectiveness of the above 40,920 4-marker combinations); among them, some 4-marker combinations with AUC greater than or equal to 0.86 are shown in Table 6, with AUC values ​​ranging from 0.86 to 0.9036. The ROC curves of some 4-marker combinations (CEACAM5, FGA, AREG, and HEG1; SERPINA1, ADAM12, FAP, and PRDX1) are shown in Figure 6. It can be seen that the above 40,920 4-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0195] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 7. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0196] Table 6 Some 4-marker combinations with prediction effectiveness AUC greater than or equal to 0.86 in the test set

[0197] 5-marker combination: Based on the 4-marker combination, the combination with AUC greater than or equal to 0.86 was selected for further verification. Among these combinations, for combinations with 3 protein duplications, the combination with the highest AUC was retained and the other combinations were eliminated. Finally, 110 combinations were obtained by deduplication (the 4-marker combinations marked in italics in Table 6, i.e., the 110 4-marker combinations in the invention content), and then combined with the remaining 71 proteins, for a total of 7810 combinations, such as: ADAM12, AGR3, MAMDC4, IL1RAP and TNC; PDIA4, PKD1, PEPD, DC The predictive efficacy AUC values ​​for the 7810 5-marker combinations (e.g., XR and TBCB; CEACAM5, TNC, FGA, HEG1, and DCXR) ranged from 0.82 to 0.9377. (Due to the large number of combinations, the AUC values ​​for each 5-marker combination are not listed individually; only the AUC range for the 7810 5-marker combinations is provided to demonstrate the diagnostic efficacy of these 7810 5-marker combinations.) Table 7 lists some 5-marker combinations with AUCs greater than or equal to 0.9246, with AUC values ​​ranging from 0.9246 to 0.9377. The ROC curves for some 5-marker combinations (ADAM12, AGR3, MAMDC4, IL1RAP, and TNC; CEACAM5, TNC, FGA, HEG1, and DCXR) are shown in Figure 8. Consequently, these 7810 5-marker combinations can be used to distinguish colorectal cancer from colorectal adenomas.

[0198] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 9. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0199] Table 7: Some 5-marker combinations with prediction effectiveness AUC greater than or equal to 0.9246 in the test set

[0200] 6-marker combination: Based on the 5-marker combination, the combination with AUC greater than or equal to 0.9246 was selected for further verification. Among these combinations, 674 combinations were obtained after deduplication (the 5-marker combinations marked in italics in Table 7, i.e., the 674 5-marker combinations in the invention content), which were then combined with the remaining 70 proteins, for a total of 47,180 combinations, such as SERPINA1, CEACAM5, FGA, HEG1, AGR3 and PCDH7; PDIA4, CEACAM5, PKD1, DCX R, FGA, and PEAR1; the predictive efficacy AUC values ​​for these 47,180 6-marker combinations ranged from 0.8323 to 0.9415. (Due to the large number of combinations, the AUC values ​​for each 6-marker combination are not listed one by one; only the AUC range for the 47,180 6-marker combinations is given to demonstrate the diagnostic effectiveness of these 47,180 6-marker combinations.) Table 8 shows some 6-marker combinations with AUCs greater than or equal to 0.925, with AUC values ​​ranging from 0.925 to 0.9415. The ROC curves for some 6-marker combinations (SERPINA1, CEACAM5, FGA, HEG1, AGR3, and PCDH7; PDIA4, CEACAM5, PKD1, DCXR, FGA, and PEAR1) are shown in Figure 10. As can be seen, these 47,180 6-marker combinations can be used to distinguish colorectal cancer from colorectal adenomas.

[0201] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 11. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0202] Table 8 Six-marker combinations with prediction effectiveness AUC greater than or equal to 0.925 in the test set

[0203] 7-markers combination: Based on the 6-markers combination, the combination with AUC greater than or equal to 0.925 was selected for further verification, and 475 combinations were obtained (the 6-markers combination in Table 8, i.e., the 475 6-markers combinations in the invention content), which were then combined with the remaining 69 proteins, for a total of 32,775 combinations, such as ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1 and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7 and ADAMTSL4; AREG, ADAM 12, PKD1, DCXR, CEACAM5, PEAR1 and ADAMTSL4; etc.; the predictive efficacy AUC values ​​of these 32775 7-marker combinations ranged from 0.8426 to 0.9486 (due to the large number of combinations, the AUC values ​​of the 7-marker combinations are not listed one by one, and only the range values ​​of the AUC values ​​of the 32775 7-marker combinations are given to demonstrate the diagnostic effect of the above 32775 7-marker combinations); among them, some 7-marker combinations with AUC greater than or equal to 0.935 are shown in Table 9, and the AUC values ​​ranged from 0.935 to 0.9486. ROC curves for some 7-marker combinations (ADAM12, FGA, AGR3, IL1RAP, CEACAM5, SPINT1, and HEG1; ADAM12, CEACAM5, DCXR, IL1RAP, FGA, PCDH7, and ADAMTSL4; AREG, ADAM12, PKD1, DCXR, CEACAM5, PEAR1, and ADAMTSL4) are shown in Figures 12A and 12B. As can be seen, the above 32,775 7-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0204] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 13. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0205] Table 9: Some 7-marker combinations with prediction effectiveness AUC greater than or equal to 0.935 in the test set

[0206] 8-markers combination: Based on the 7-markers combination, the combination with AUC greater than or equal to 0.935 was selected for further verification, and 301 combinations were obtained (the 7-markers combination in Table 9, i.e., the 301 7-markers combinations in the invention content), which were then combined with the remaining 68 proteins, for a total of 20,468 combinations, such as ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4 and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP and KRT19; CEACAM5 , SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP and ASPN, etc.; the predictive efficacy AUC values ​​of these 20468 8-marker combinations ranged from 0.8455 to 0.9398 (due to too many combinations, the AUC values ​​of the 8-marker combinations are not listed one by one, and only the range values ​​of the AUC values ​​of the 20468 8-marker combinations are given to demonstrate the diagnostic effect of the above 20468 8-marker combinations); among them, some 8-marker combinations with AUC greater than or equal to 0.93 are shown in Table 10, and the AUC values ​​ranged from 0.93 to 0.9398. The ROC curves for some 8-marker combinations (ADAM12, CEACAM5, FGA, HEG1, PDIA4, PCDH7, CNTN4, and IL1RAP; AREG, FGA, PEPD, HEG1, CEACAM5, AGR3, IL1RAP, and KRT19; and CEACAM5, SLAMF8, PEPD, HEG1, TNC, PDIA4, IL1RAP, and ASPN) are shown in Figures 14A and 14B. As can be seen, the above 20,468 8-marker combinations can be used to distinguish colorectal cancer from colorectal adenoma.

[0207] The AUC comparison results of the RandomForest model and the XGBboost model are shown in Figure 15. The AUC consistency of the RandomForest model and the XGBboost model is very good: the average AUC of the 100 random models is basically the same, and the standard deviation SD (black line) of the AUC of the 100 random models is also very close, that is, the stability is also very close, which shows the interchangeability of the model algorithms in the implementation scheme.

[0208] Table 10: Some 8-marker combinations with prediction effectiveness AUC greater than or equal to 0.93 in the test set

[0209] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be considered as equivalent replacement methods and are included in the scope of protection of the present invention.

Claims

1. Application of detection marker substances in product preparation: The product is used to differentiate colorectal cancer from colorectal adenoma; The marker is A, and A comprises at least one of B; The B group includes: ACY1, ADAM12, ADAMTSL4, AGR3, ALCAM, APOA4, AREG, ASPN, C1QTNF1, CA14, CANT1, CD34, CD55, CD58, CDH23, CEACAM5, CFP, CKB, CLEC3B, CNTN4, COMP, CPM, DCXR, DDC, DPP4, ENPP6, ESM1, FAP, FGA, GDF15, GNAS, HEG1, HPGDS, IGFBP2, IL17RA, IL1R2, IL1RAP, ITGA 11. ITGAV, ITIH3, KHK, KRT19, LILRA4, LRCH4, LRG1, MAMDC4, MCAM, MEGF9, MFGE8, MZB1, NAGPA, NCS1, PCDH7, PDIA4, PEAR1, PEPD, PK D1, PLXDC2, PPY, PRDX1, PRTN3, PTH, PTX3, RAB37, RPGR, RTN4R, SERPINA1, SLAMF8, SPINT1, SSBP1, SSC4D, TBCB, TINAGL1, TNC, UPB1.

2. The use according to claim 1, characterized in that: Said A includes any 1, 2, 3, 4, 5, 6, 7, or 8 of said B; Preferably, said A comprises a single marker, and said single marker is any one of said B; Preferably, the single marker is: CLEC3B, IGFBP2, FAP, CEACAM5, AREG, PLXDC2, MEGF9, DPP4, CKB, TNC, CFP, LRG1, ITIH3, FGA, CD34, SERPINA1, HEG1, MAMDC4, MZB1, MCAM, ADAM12, PEPD, AGR3, PTX3, SSC4D, GDF15, ADAMTSL4, ITGA11, NAGPA, CD58, SSB P1, ITGAV, CPM, RTN4R, APOA4, PTH, C1QTNF1, DCXR, UPB1, TINAGL1, CNTN4, IL17RA, MFGE8, CA14, RPGR, ACY1, PKD1, P EAR1, PDIA4, SLAMF8, PCDH7, NCS1, PPY, KRT19, ENPP6, GNAS, LILRA4, RAB37, HPGDS, ESM1, IL1R2, COMP, KHK, or CDH23.

3. The use according to claim 1, characterized in that: Said A comprises a combination of 2 markers, and said combination of 2 markers is any 2 of said B; Preferably, said A comprises a combination of 3 markers, and said combination of 3 markers is any 3 of said B; Preferably, the 3 markers combination is any 3 of C, wherein C is: ADAM12, ADAMTSL4, AGR3, ALCAM, AREG, ASPN, CD34, CD55, CEACAM5, CLEC3B, DCXR, FAP, FGA, HEG1, IGFBP2, IL17RA, IL1RAP, ITIH3, LRG1, MAMDC4, MCAM, MEGF 9, NCS1, PDIA4, PEPD, PKD1, PLXDC2, PRDX1, PRTN3, SERPINA1, SLAMF8, TBCB, TNC; Preferably, said A comprises a combination of 4 markers, and said combination of 4 markers is any 4 of said B; Preferably, the 4 markers combination is any 4 of the C; Preferably, said A comprises a combination of 5 markers, and said combination of 5 markers is any five of said B; Preferably, the 5 markers are combined into a1) and a2): a1) the combination of the four markers; a2) any one of the above B; a2) is different from any one of the markers in the combination of 4 markers in a1); Preferably, said A comprises a combination of 6 markers, and said combination of 6 markers is any six of said B; Preferably, the 6 markers are combined into b1) and b2): b1) the 5 markers combination; b2) any one of the above B; b2) is different from any one of the markers in the combination of 5 markers in b1); Preferably, said A comprises a combination of 7 markers, and said combination of 7 markers is any seven of said B; Preferably, the 7 markers are combined into c1) and c2): c1) the 6 markers combination; c2) any one of the above B; Said c2) is different from any one of the markers in the combination of 6 markers in c1); Preferably, said A comprises an 8-markers combination, and said 8-markers combination is any eight of said B; Preferably, the 8 markers are combined into d1) and d2): d1) the 7 markers combination; d2) any one of the above B; The d2) is different from any one of the markers in the 7 markers combination in d1).

4. The use according to any one of claims 1 to 3, characterized in that: Said A further comprises at least one of E, the union of said E and said A in any one of claims 1-3 is said B, and said E has no intersection with said A in any one of claims 1-3; Preferably, the test sample of the product is selected from at least one of body fluids, tissues, cells, and excretions of the subject to be tested; Preferably, the body fluid comprises at least one of blood, lymph, pleural effusion, cerebrospinal fluid, joint fluid, ascites, saliva, lymph, and body fluid; Preferably, the tissue comprises intestinal mucosal tissue; Preferably, the blood comprises at least one of serum, plasma, dried blood spots, and whole blood; Preferably, the excreta comprises at least one of urine, feces, and tears; Preferably, the subject to be tested comprises a mammal; Preferably, the substance for detecting a marker comprises a substance for detecting a marker at the gene level and / or protein level; Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, polymerase chain reaction (PCR), biochip method, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance technology, immuno-PCR technology, and biotin-avidin technology; Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation assay, flow cytometry fluorescence resolution, and single molecule detection technology; Preferably, the substance for detecting the marker is selected from: one or more of a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer; Preferably, the substance specific for the marker comprises any one of h1) to h4): h1) an antibody that specifically binds to the marker; h2) a ligand protein or polypeptide that specifically binds to the marker; h3) non-protein compounds that specifically recognize markers; h4) nucleic acid aptamers that specifically recognize markers; Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody; Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system; Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma; Preferably, the product further comprises auxiliary detection reagents for gene expression, and the auxiliary detection reagents for gene expression include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance; Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance. 5 . A marker combination comprising at least two of the Bs according to any one of claims 1 to 4 .

6. The marker combination according to claim 5, characterized in that: The marker combination comprises any 2, 3, 4, 5, 6, 7, or 8 of the B in any one of claims 1 to 4; Preferably, the marker combination is A described in any one of claims 3-4.

7. A product comprising a substance for detecting the marker combination according to any one of claims 5-6.

8. The product according to claim 7, characterized in that: The substance for detecting the marker combination includes a substance for detecting the marker combination at the gene level and / or protein level; Preferably, the substance comprises a substance for one or more detection techniques or methods selected from the group consisting of immunohistochemistry, Western blotting, Northern blotting, PCR, biochip, nucleic acid sequencing, amino acid sequencing, high performance liquid chromatography, capillary gel electrophoresis, near infrared spectroscopy, mass spectrometry, surface plasmon resonance, immuno-PCR, and biotin-avidin technology; Preferably, the immunohistochemistry method comprises at least one of enzyme-linked immunosorbent assay, immunofluorescence assay, radioimmunoassay, immunoprecipitation, immunochemiluminescence, colloidal gold immunoassay, fluorescence immunochromatography, complement fixation assay, flow cytometry fluorescence resolution, and single molecule detection technology; Preferably, the substance for detecting the marker combination is selected from one or more of: a substance specific to the marker, a marker-specific probe, a gene chip, a protein chip, and a PCR primer; Preferably, the substance specific for the marker comprises any one of h1) to h4): h1) an antibody that specifically binds to the marker; h2) a ligand protein or polypeptide that specifically binds to the marker; h3) non-protein compounds that specifically recognize markers; h4) nucleic acid aptamers that specifically recognize markers; Preferably, the antibody comprises at least one of a polyclonal antibody, a monoclonal antibody, a single-chain antibody, a functional antibody fragment, an antibody Fab region, a nanobody, a chimeric antibody, and a multispecific antibody; Preferably, the product comprises at least one of a reagent, a kit, a test paper, a chip, a device, and a system; Preferably, the product further comprises substances for detecting other markers for distinguishing colorectal cancer from colorectal adenoma; Preferably, the product further comprises auxiliary detection reagents for gene expression, and the auxiliary detection reagents for gene expression include: a reaction reagent for visualizing the amplicon corresponding to the primer, an RNA extraction reagent, a reverse transcription reagent, a cDNA amplification reagent, a standard substance for preparing a standard curve, and at least one of a positive control substance; Preferably, the product further comprises an auxiliary detection reagent for protein expression, and the auxiliary detection reagent for protein expression comprises at least one of a color developer, a blocking solution, an antibody diluent, a washing buffer, a color stop solution, a standard substance for preparing a standard curve, and a positive control substance.

9. A method for constructing a model, comprising the step of constructing a model using the markers according to any one of claims 1 to 4.

10. The construction method according to claim 9, characterized in that: The method comprises the step of constructing a model using the marker combination according to claim 5 or 6; Preferably, the algorithm for constructing the model includes at least one of logarithmic regression, linear discriminant analysis, eigengene linear discriminant analysis, support vector machine, random forest, recursive partitioning tree, XGBoost, ShrunkenCentroids, StepAIC, Kth-Nearest Neighbor, Boosting, neural network, Bayesian network, and hidden Markov model.

11. A device or system comprising: Detection module: used to detect the content, activity and / or expression of the marker described in any one of claims 1 to 4 in the test sample; and Analysis module: used to input the data obtained by the detection module into the model constructed according to the construction method according to claim 9 or 10 for analysis.

12. The device or system according to claim 11, characterized in that: The detection module is used to detect the content, activity and / or expression of the marker combination according to claim 5 or 6 in the test sample; Preferably, the test sample is the test sample described in claim 4; Preferably, the device or system further comprises: an output module for outputting information according to the analysis results obtained by the analysis module.

13. A computer device comprising a memory and a processor, wherein the memory stores a program, and when the processor executes the program, it implements any one of the following methods i1)-i2): i1) A method for constructing a model according to claim 9 or 10; i2) S1: Obtaining the content, activity and / or expression of the marker according to any one of claims 1 to 4 in the test sample; and S2: Input the data acquired in S1 into the model constructed according to the construction method according to claim 9 or 10 for analysis.

14. The computer device according to claim 13, wherein: i2) S1 is to obtain the content, activity and / or expression of the marker combination according to claim 5 or 6 in the test sample; Preferably, the test sample is the test sample described in claim 4; Preferably, i2) further includes the following step: outputting information based on the obtained analysis results.

15. A computer readable storage medium comprising a stored computer program; wherein: When the computer program is executed, the computer-readable storage medium is controlled to implement any one of the methods i1)-i2) in claim 13 or 14.

16. A method for distinguishing colorectal cancer from colorectal adenoma, comprising the step of detecting the content, expression level and / or activity of the marker according to any one of claims 1 to 4 in a test sample.

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