Tooth surface cleaning method

Abstract

The present invention provides a tooth surface cleaning method which allows cleaning without damaging a tooth surface, can effectively whiten teeth, and can effectively realize prevention and healing of periodontal disease, etc. The present invention relates to a tooth surface cleaning method in which cleaning is performed by spraying a dental spray powder onto a supragingival tooth surface and / or a subgingival tooth surface, wherein the method uses a dental spray powder containing raffinose. The dental spray powder further contains one or more of silicon, titanium, or a bioactive glass. The median diameter of the raffinose is preferably 10 μm-100 μm.

Description

Tooth surface cleaning method

[0001] The present invention relates to a tooth surface cleaning method for cleaning tooth surfaces by spraying dental spray powder onto supragingival and / or subgingival tooth surfaces.

[0002] In recent years, powder-blast tooth cleaning has become a widely used method for cleaning tooth or root surfaces. Because powder-blast tooth cleaning can rapidly and efficiently remove stains, calculus, and plaque, it has become an alternative or adjunct to mechanical tooth cleaning methods using hand instruments or ultrasonic procedures.

[0003] Tooth surface cleaning methods using compressed air, fine powder particles, and water jets are generally divided into so-called air abrasion jet cutting and air polishing jet polishing. Both of these methods are based on the principle that by using a water jet to collide a mixture of powder and compressed air against the tooth surface (root surface), it is possible to remove enamel and dentin and deposits attached to the tooth surface (root surface).

[0004] The powders used in the above tooth surface cleaning methods are composed of various substances, such as sodium bicarbonate, calcium carbonate, etc. Sodium bicarbonate and calcium carbonate are excellent in that they are well tolerated by patients undergoing treatment, but when cleaning the root surface or dentin surface, they have the problem of scraping off the surface.

[0005] Furthermore, dental spray powders containing sugars, such as disaccharides (see Patent Document 1) and oligosaccharides (see Patent Document 2), have been proposed. Dental spray powders using such sugars are based on the affinity of sugars to the body, but depending on the type of sugar, although they are effective in cleaning tooth surfaces, they may also damage dental crowns, which are placed on teeth during treatment.

[0006] Furthermore, in the tooth surface cleaning techniques using dental spray powders that have been proposed in the past, although it is required to whiten the teeth after cleaning, that is, to remove stains from the tooth surface, so that the tooth surface looks beautiful after cleaning, the current situation is that a fully satisfactory result has not been achieved.

[0007] Furthermore, there is currently a demand for a tooth surface cleaning technique that can efficiently prevent and cure periodontal disease by performing tooth surface cleaning treatment.

[0008] JP 2017-531690 A JP 2021-91741 A

[0009] The present invention has been made under the above-mentioned background, and aims to provide a tooth surface cleaning method using powder spray that can clean teeth without damaging the surfaces of teeth or dental fillings, can effectively whiten teeth, and can effectively prevent and cure periodontal disease and the like.

[0010] As a result of extensive research into oligosaccharides as materials for dental spray powders, the inventors discovered that the properties of raffinose, a type of oligosaccharide, make it extremely effective for use in cleaning tooth surfaces, leading to the invention of the present invention.

[0011] The present invention relates to a tooth surface cleaning method for cleaning supragingival and / or subgingival tooth surfaces by spraying dental spray powder, characterized in that the tooth surface cleaning method uses a dental spray powder containing raffinose.

[0012] The raffinose contained in the dental spray powder of the present invention is a type of oligosaccharide extracted from plants and used in foods and cosmetics, so there is no problem with its use in the oral cavity. Unlike other oligosaccharides, raffinose has low hygroscopicity and relatively low crystalline hardness. It also has the property of forming a lamellar liquid crystal structure when attached to the tooth surface. Furthermore, it is less likely to undergo the Maillard reaction (browning reaction) that occurs in sugars.

[0013] The dental spray powder used in the tooth surface cleaning method according to the present invention is usually produced by mixing raffinose with a solidification inhibitor or a surfactant. Many sugars other than raffinose have high water absorption properties, and therefore, when used in the oral cavity, they tend to become viscous due to the presence of moisture and temperatures around human body temperature, making them insufficient for effective tooth surface cleaning. However, raffinose has low water absorption properties, making it suitable for use as a dental spray powder. Furthermore, raffinose crystals have a relatively low hardness, which can prevent scratches on the tooth surface, crown, and other surfaces.

[0014] The tooth surface cleaning method according to the present invention uses a dental spray powder containing raffinose, and therefore, when tooth surfaces are cleaned, raffinose adheres to the tooth surface and periodontal tissues. Raffinose is known to form a lamellar liquid crystal structure, which provides a barrier effect for the tooth surface epithelium. Furthermore, when raffinose penetrates into periodontal pockets, the barrier effect of the lamellar liquid crystal structure is expected to prevent and cure periodontal disease. Furthermore, raffinose has a lamellar liquid crystal structure, is transparent or white, and is resistant to the Maillard reaction, making it possible to maintain the whitening of tooth surfaces for a long period of time after cleaning.

[0015] In the tooth surface cleaning method of the present invention, the dental spray powder preferably contains at least one of silicon, titanium, and bioactive glass. Silicon and titanium are preferably silicon oxide (SiO ２ ) and titanium oxide (TiO ２ ) can be incorporated into the dental spray powder, and the inclusion of these materials can further enhance the whitening of tooth surfaces. For example, after proteins that have penetrated into the enamel rod sheaths of teeth are removed by the dental spray powder of the present invention, the silicon and titanium that have adhered to the enamel rod sheaths diffuse natural light, making the tooth surface appear whiter. In addition, the lamellar liquid crystal structure of raffinose is known to have the property of easily absorbing inorganic substances, making it possible to efficiently adhere silicon and titanium to the tooth surface.

[0016] Bioactive glass is an absorbable synthetic material made from metal oxides, and is used as a biomaterial in the dental and medical fields for repairing bone defects and treating skin injuries. When this bioactive glass is combined with raffinose and included in dental spray powder, tooth surfaces can be cleaned without damaging the surfaces of teeth and crowns. Furthermore, the affinity and easy binding properties of bioactive glass and raffinose are expected to change the interaction with cells, improving the healing function of tooth defects and other areas.

[0017] The raffinose contained in the dental spray powder of the present invention is hydrophobic and stable in the states of hydrates 1 to 5, and therefore when combined with bioactive glass, it exhibits the following effects. ２＋ The presence of raffinose and other compounds interacts with the hydroxyl groups (-OH) of raffinose, easily binding the bioactive glass to raffinose through hydrogen bonds and ionic interactions. The vitrification of raffinose and the adsorption of the bioactive glass to the tooth surface tend to form a protective film. This adjusts the dissolution behavior and ion elution of the bioactive glass, improving its functionality and suppressing the occurrence of scratches on the tooth surface and crowns caused by the hard bioactive glass. Furthermore, the presence of raffinose is expected to improve the hydrophilicity of the bioactive glass, altering its interaction with cells and improving the healing function of tooth defects. Additionally, raffinose tends to protect biomolecules in the dry state, thereby improving the shelf life of dental spray powders containing bioactive glass.

[0018] The raffinose used in the tooth surface cleaning method according to the present invention preferably has a median diameter (D50) of 10 μm to 100 μm. If the diameter is less than 10 μm, the tooth surface cleaning ability tends to be reduced, and if the diameter exceeds 100 μm, the tooth surface is highly invasive. Furthermore, when a dental spray powder is prepared that is mainly composed of raffinose, the raffinose content is preferably 70 wt % to 99.9 wt %. If the diameter is less than 70 wt %, the tooth surface cleaning ability tends to be reduced, and if the diameter exceeds 99.9 wt %, the density between crystals tends to increase, resulting in poor operability. If a dental spray powder is prepared that is not mainly composed of raffinose but mainly composed of a material to be mixed with it, the raffinose content may be less than 70 wt %. For example, a dental spray powder can be made by mixing 80% by weight of bioactive glass and 20% by weight of raffinose. In such a case, the properties of the mixed material (the properties of the bioactive glass) take priority, but by adjusting the presence and content of raffinose, a dental spray powder can be made in which the properties of the mixed material are controlled.

[0019] In the tooth surface cleaning method according to the present invention, it is effective to clean the tooth surface using a dental spray powder and then irradiate the cleaned tooth surface with a laser. If the cleaned tooth surface is irradiated with a laser of a specific wavelength after the tooth surface cleaning method according to the present invention, the barrier effect of the tooth surface can be improved by crystallization due to molecular fusion of raffinose, silicon, titanium, bioactive glass, etc. attached to the tooth surface. It is preferable to control the wavelength of the irradiated laser according to the substances contained in the dental spray powder.

[0020] According to the tooth surface cleaning method of the present invention, cleaning can be performed without damaging the tooth surface or the surface of dental fillings, teeth can be effectively whitened, and periodontal disease and the like can be effectively prevented and cured.

[0021] SEM photograph of the cleaning test of the aluminum substrate surface. Photograph of the copper substrate surface after cleaning treatment. Photograph of the copper substrate surface after cleaning treatment. Photograph of the oral cavity 3 months after tooth surface cleaning. Photograph of the oral cavity 3 months after tooth surface cleaning.

[0022] First, the results of a cleaning test on the surface of an aluminum substrate conducted to confirm the cutting power of raffinose on the tooth surface will be described.

[0023] The sample used in this cleaning test was an aluminum substrate measuring 50 mm x 25 mm and 0.5 mm thick. The surface of this aluminum substrate had streaky grinding scratches, and the cleaning test was carried out on the surface of the aluminum substrate, which was marked black with an oil-based marker.

[0024] The dental spray powders used in the cleaning test were three types: raffinose with a content of 98% or more, calcium carbonate with a content of 98% or more for comparison, and erythritol with a content of 98% or more.

[0025] Three types of dental aerosol powders were sprayed onto the surface of an aluminum substrate to clean the surface. A commercially available dental aerosol cutter (product "Aquacare", manufactured by Medivance Instruments, UK) was used as the aerosol sprayer. The handpiece had an inner diameter of 0.8 mm, a spray pressure of 2.0 MPa, and a spray distance of 10 mm. The water volume was set to a medium level according to the sprayer's scale.

[0026] Figure 1 shows SEM photographs (magnification: 500x) of the surface of an aluminum substrate that underwent a cleaning test. (A) in Figure 1 shows the surface of the aluminum substrate before the cleaning test, (B) shows the surface in the case of calcium carbonate, (C) shows the surface in the case of erythritol (a type of alditol), and (D) shows the surface in the case of raffinose.

[0027] As shown in Figure 1(A), it was found that the streaky grinding scratches on the surface of each substrate after the cleaning test had disappeared, but in the cases of calcium carbonate (B) and erythritol (C), the grinding scratches had almost completely disappeared. On the other hand, in the case of raffinose (D), it was found that the cleaning treatment had only resulted in faint streaky grinding scratches.

[0028] The physical crystal strength at room temperature of 20°C (Journal of Cryobiology and Cryotechnology, Vol. 66, No. 1, pp. 1-10, 2020, Analysis of the Behavior of Single-Chain Glycolipids Under Freezing and Drying, Seikei University, Department of Materials and Life Sciences, Juzaburo Ogawa) for erythritol is 2.0 MPa compressive strength, 0.4 MPa shear strength, and 1.0 MPa bending strength, while for raffinose it is 1.8 MPa compressive strength, 0.3 MPa shear strength, and 0.9 MPa bending strength. This indicates that raffinose crystals are slightly softer than erythritol, and the results of the observation photograph shown in Figure 1 demonstrate that the use of raffinose can prevent scratches on the surface of teeth and crowns.

[0029] The results of investigating the tooth surface whitening effect of the tooth surface cleaning method of the present invention will now be described.

[0030] The tooth surface whitening effect test was carried out using a dental spray powder containing a mixture of raffinose (content 98.0%), silica (Aerosil R972 manufactured by EVONIK Co., Ltd. / content 1.0%), and titanium oxide (manufactured by Sakai Chemical Industry Co., Ltd. / content 1.0%).

[0031] Two extracted teeth were used as test subjects. Dental spray powder was sprayed onto the surfaces of the extracted teeth using a commercially available tooth surface cleaner (Handy Jet, manufactured by Morita Corporation) at a pressure of 2.0 MPa for 30 seconds. The tooth surface after cleaning was then visually inspected for brightness using a tooth color sample (VITA Classical Shade Guide). The tooth surface whitening effect was evaluated by comparing the tooth surface before cleaning with the tooth surface after a second tooth surface cleaning under the same conditions. The tooth surface brightness was also visually inspected and compared with the tooth surface brightness of the extracted teeth before cleaning. Tables 1 and 2 show the results of the tooth surface whitening effect test.

[0032]

[0033]

[0034] The symbols in the color sample columns in Tables 1 and 2 indicate the order of brightness divided into 16 levels in the VITA Classical Shade Guide (tooth color sample). Specifically, the symbols correspond to the 16 levels of tooth color samples roughly divided into B1 / A1 / B2 / D2 / A2 / C1 / C2 / D3 / A3 / D4 / B3 / A3.5 / B4 / C3 / A4 / C4 (A group: reddish brown, B group: reddish yellow, C group: gray, D group: reddish gray), with the B1 side indicating lighter brightness and the C4 side indicating darker brightness.

[0035] As shown in Tables 1 and 2, it was found that the first cleaning treatment brightened the brightness of the tooth surface for each of the two extracted teeth. Furthermore, it was confirmed that the second cleaning treatment for each of the two extracted teeth brightened the brightness of the tooth surface even more than the first cleaning treatment.

[0036] Furthermore, the results of an additional test on the tooth surface whitening effect of the tooth surface cleaning method of the present invention will be described. This additional tooth surface whitening effect test was conducted using a dental spray powder containing a mixture of raffinose (content 99.0%) and silica (Aerosil R972, manufactured by EVONIK, content 1.0%). The commercially available tooth surface cleaner and test conditions used were the same as those in Tables 1 and 2 above, but the brightness of the tooth surface was measured using an automatic colorimeter (VITA Easyshade V, manufactured by Vita). The results of the test on two extracted teeth are shown in Tables 3 and 4.

[0037]

[0038]

[0039] The color swatch results in Tables 3 and 4 are values ​​measured by an automatic colorimeter.

[0040] Unlike the cases in Tables 1 and 2, this additional tooth surface whitening effect test was conducted using a dental spray powder that did not contain titanium oxide, and it was found that the first cleaning treatment brightened the tooth surface brightness of each of the two extracted teeth. Furthermore, it was confirmed that the second cleaning treatment brightened the tooth surface brightness even more than the first cleaning treatment.

[0041] Next, a dental spray powder combining raffinose and bioactive glass will be described. First, the results of examining the cleaning power of dental spray powders containing bioactive glass will be described. The dental spray powder used here was a mixture of 70 wt% raffinose (product name: Raffinose FP, manufactured by Nippon Beet Sugar Co., Ltd.; a mixture of 99.0 wt% raffinose and 1.0 wt% silica (R972)) and 30 wt% bioactive glass (product name: Silk, manufactured by Defotex Research; a mixture of 99.0 wt% bioactive glass (45S5) and 1.0 wt% silica (R972)). For comparison, a dental spray powder containing 100 wt% bioactive glass (45S5) was also used. The cleaning target was a copper substrate (a 10-yen coin with copper oxide formed on its surface) painted black with a permanent marker.

[0042] Two types of dental aerosol powders were sprayed onto the surface of the copper substrate for cleaning. A commercially available dental aerosol cutter (product "Aquacare", manufactured by Medivance Instruments, UK) was used as the aerosol sprayer. The handpiece had an inner diameter of 0.8 mm, a spray pressure of 2.0 MPa, and a spray distance of 10 mm. The water volume was set to a medium level according to the sprayer's scale.

[0043] Photographs of the copper substrate surface after cleaning are shown in Figures 2 and 3. Figure 2 shows the dental spray powder containing 70% by weight of raffinose and 30% by weight of bioactive glass, and Figure 3 shows the dental spray powder containing 100% by weight of bioactive glass.

[0044] As shown in Figure 2, when dental spray powder containing 70 wt% raffinose and 30 wt% bioactive glass was used, the oil-based marker was almost completely removed from the surface. In contrast, when dental spray powder containing 100 wt% bioactive glass was used, the oil-based marker was removed, but some copper oxide on the copper surface was also removed (see the white area inside the 10-yen coin in Figure 3). Because bioactive glass has a hardness of approximately 400 Hv (Vickers hardness), it was found that using bioactive glass alone as dental spray powder tends to scratch the tooth surface, exposed root surface, crown, and other surfaces. In contrast, when raffinose and bioactive glass are combined, raffinose binds to the bioactive glass surface, and the raffinose crystals act as a buffer during spray cleaning, allowing biofilms and stains attached to the tooth surface to be cleaned and removed without scratching the tooth surface, exposed root surface, crown, and other surfaces.

[0045] Finally, the results of an evaluation of restaining properties after tooth surface cleaning are described. The dental spray powder used here was a mixture of 70 wt% raffinose (product name: Raffinose FP, manufactured by Nippon Beet Sugar Co., Ltd.; a mixture of 99.0 wt% raffinose and 1.0 wt% silica (R972)) and 30 wt% bioactive glass (product name: Silk, manufactured by Defotex Research; a mixture of 99.0 wt% bioactive glass (45S5) and 1.0 wt% silica (R972)). For comparison, a dental spray powder containing 100 wt% calcium carbonate (98% or more) was also used. The tooth surfaces to be cleaned for the restaining properties evaluation were stained areas of the lower front teeth (four teeth) of the same individual. The tooth surface cleaning conditions were as follows: dental spray powder was sprayed onto four stained lower front teeth using a commercially available tooth surface cleaner (product name: Handyette, manufactured by Morita Corporation) at a pressure of 2.0 MPa for 30 seconds to remove stains. Re-adhesion evaluation was performed by observing the four lower front teeth three months after tooth surface cleaning.

[0046] Figures 4 and 5 show photographs of the oral cavity observed three months after tooth surface cleaning. Figure 4 shows the case of a dental spray powder containing 70% by weight of raffinose and 30% by weight of bioactive glass, and Figure 5 shows the case of a dental spray powder containing 100% by weight of calcium carbonate.

[0047] As shown in Figure 4, in the case of the dental spray powder containing a mixture of 70% by weight of raffinose and 30% by weight of bioactive glass, almost no re-staining was observed on the tooth surfaces (four lower front teeth) after three months. On the other hand, in the case of the dental spray powder containing 100% by weight of calcium carbonate, clear re-staining was observed on the tooth surfaces (four lower front teeth) after three months. The results of this re-staining evaluation revealed that when raffinose adheres to the tooth surface and periodontal tissue, the lamellar liquid crystal structure formed by this raffinose improves the barrier effect of the tooth surface epithelium, thereby effectively suppressing re-staining.

Claims

1. A tooth surface cleaning method for cleaning supragingival and / or subgingival tooth surfaces by spraying dental spray powder onto the tooth surfaces, characterized in that the dental spray powder contains raffinose.

2. The tooth surface cleaning method according to claim 1, wherein the dental spray powder contains at least one of silicon, titanium, and bioactive glass.

3. A tooth surface cleaning method according to claim 1 or 2, wherein the median diameter of the raffinose is 10 μm to 100 μm.

4. A tooth surface cleaning method according to any one of claims 1 to 3, characterized in that after cleaning the tooth surface with dental spray powder, the cleaned tooth surface is irradiated with a laser.

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