Wearable system for the modification of the mechanical properties and structures in the eye

Abstract

A wearable system and methods for modifying properties of eyes are provided. The system includes an ultrasonic device; at least one sealed cavity; a fluid and lighting environment control device; a controller; one or more feedback sensors; and a computing device. The method includes applying vibrations through actuators in contact with an eye socket bone through skin; warming a cavity to set temperature to a first temperature for a period up to a predetermined time except when the temperature exceeds a second temperature; setting vibration cycles after the set temperature is reached; initiating a cavity pressure cycling after the set temperature is reached and after the setting vibration cycles is completed; and completing the cavity pressure cycling and then completing the warming. The system and methods can be applied to surgical treatments, medications, finger massage, or used independently to modify the tissue properties of the eye.

Description

[0001] DESCRIPTION

[0002] TITLE

[0003] WEARABLE SYSTEM FOR THE MODIFICATION OF THE MECHANICAL PROPERTIES AND STRUCTURES IN THE EYE

[0004] CROSS-REFERENCE TO RELATED APPLICATION

[0005] The present application claims the benefit of U.S. Provisional Application Serial No. 63 / 632,525, filed April 11, 2024, which is hereby incorporated by reference herein in its entirety, including any figures, tables, or drawings.

[0006] BRIEF SUMMARY OF THE INVENTION

[0007] Embodiments of the subject invention pertain to a wearable system and methods for modification of mechanical properties and structures in the eyes.

[0008] According to an embodiment of the subject invention, a wearable system for modifying properties of eyes is provided. The system comprises an ultrasonic device; at least one sealed cavity; a fluid and lighting environment control device; a controller; one or more feedback sensors; and a computing device. The fluid and lighting environment control device is configured to control liquid or gas. The ultrasonic device is disposed to be in contact with skin around an eye socket. Moreover, the ultrasonic device is configured to apply waves of ultrasound to the eye socket and to connective tissues connected to the eye socket. The fluid and lighting environment control device is configured to sense and control fluid and lighting properties. The fluid properties include fluid gauge pressures, temperatures, humidities, and chemical concentrations of a fluid in the cavity. In addition, the ultrasonic device and the fluid and lighting environment control device are connected to the computing device to form a sensing-control-feedback unit to maintain a variable environment. The fluid and lighting properties and structures in fluid and lighting communication with the wearable cavity are determined and adjusted by the computing device or by a user. The structures in fluid and lighting communication with the wearable cavity include eye globe, channels connecting interior of the eye to a surface of the eye, and channels on eyelids for transporting fluid and lighting to the cavity.

[0009] In another embodiment of the subject invention, a method for modifying properties of eyes is provided. The method comprises applying vibrations through actuators in contact with the eye socket bone through the skin; warming a cavity to set temperature to a first temperature for a period up to a predetermined time except when the temperature exceeds a second temperature; setting vibration cycles after the set temperature is reached; initiating a cavity pressure cycling after the set temperature is reached and after the setting vibration cycles is completed; and completing the cavity pressure cycling and then completing the warming. The first temperature is 40 °C, the predetermined time is 30 minutes, and the second temperature is 42 °C. The actuator is set to vibrate in a range between 0.5 to 4 MHz. Moreover, the vibration is set to encompass the eye socket, enabling relaxation of connected appendages and tissues connected to the eye socket. The cavity pressure cycling is performed in a range between 500 and 900 mmHg and in a period up to 30 minutes. The cavity pressure cycling comprises initiation cycles, modification cycles, and ending cycles. In particular, the initiation cycles comprise step-hold pressure cycles in steps of at least 5 mmHg with a period up to 1 minute to set pressure starting in dilation cycles. The modification cycles comprise at least 5 step-hold negative pressure cycles in steps of 5 mmHg with a period up to 10 minutes with or without leakage. The modification cycles comprise at least 5 step-hold negative and positive pressure cycles in steps of at least 5 mmHg with a period up to 10 minutes with or without leakage. The ending cycles comprise step-hold pressure cycles in steps of at least 5 mmHg with a period up to 1 minute to set negative pressure 2 mmHg below the outside pressure.

[0010] BRIEF DESCRIPTION OF THE DRAWINGS

[0011] FIG. 1 is a schematic diagram of blocked Meibomian glands, according to an embodiment of the subject invention.

[0012] FIG. 2 is a schematic diagram of fluid transport in Scl emm’s canal in eye pressure balance, according to an embodiment of the subject invention.

[0013] FIG. 3 illustrates mechanical behaviors of viscoelastic tissues without relaxation, according to an embodiment of the subject invention.

[0014] FIG. 4 illustrate mechanical behaviors of viscoelastic tissues with relaxation and dilation of Sclemm’s canal after relaxation, according to an embodiment of the subject invention.

[0015] FIG. 5 shows tear production changes with relaxation, according to an embodiment of the subject invention. FIG. 6 shows sustained tear production with daily wear, according to an embodiment of the subject invention.

[0016] FIG. 7 shows sustained reduction in eye pressure after sustained wear, according to an embodiment of the subject invention.

[0017] FIG. 8 is a schematic diagram showing shape changes of eye globe as a function of fluid environment changes in sealed cavity around the eye, according to an embodiment of the subject invention.

[0018] DETAILED DISCLOSURE OF THE INVENTION

[0019] Embodiments of the subject invention are directed to a wearable system and methods for modifying properties of eyes.

[0020] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term “and / or” includes any and all combinations of one or more of the associated listed items. As used herein, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well as the singular forms, unless the context clearly indicates otherwise. It will be further understood that the terms “comprises” and / or “comprising,” when used in this specification, specify the presence of stated features, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and / or groups thereof.

[0021] Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one having ordinary skill in the art to which this invention pertains. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and the present disclosure and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

[0022] When the term “about” is used herein, in conjunction with a numerical value, it is understood that the value can be in a range of 90% of the value to 110% of the value, i.e. the value can be + / - 10% of the stated value. For example, “about 1 kg” means from 0.90 kg to 1.1 kg.

[0023] According to the embodiments of the subject invention, a wearable system and methods for modifying the properties of a patient's one or both eyes are provided. The system and methods can alter the biomechanical properties of the eye and the structural shape of features in the eye.

[0024] In one embodiment, the wearable system comprises an ultrasonic device, at least one sealed cavity, a fluid and lighting environment control device, where the fluid may comprise liquid and gas, a controller, one or more feedback sensors and a computing device. In particular, the ultrasonic device is disposed in contact with the skin around the eye socket, applying waves of ultrasound to the eye socket and to the connective tissues connected to the eye socket. The environment control device is configured to sense and control fluid and lighting properties, including but not limited to, fluid gauge pressures, temperatures, the humidities, and chemical concentrations of the fluid in the cavity. The ultrasonic device and the environmental control device are connected to the computing device and a wireless module to form a sensing-control-feedback wearable unit to maintain a variable environment. Variable gauge pressures in the structures in fluid communication with the cavity and variable eye temperature are determined by the computing device or the user and communicated through the wireless module. The structures in fluid and lighting communication with the wearable cavity, including the eye globe, the channels connecting the interior of the eye to the surface of the eye, and the channels on the eyelids for the transport of fluid and lighting to the wearable cavity may be adjusted. Controlling the cavity environment with the eye and controlling the ultrasonic vibration on the eye can drive a desired change in the biomechanical properties and relaxation of the structures in fluid and lighting communication with the cavity. With regular repeated use, the wearable can drive and sustain a desired change in the size and shape of the eye globe, as well as the size and shape of the channels, both during and after repeated wear.

[0025] According to the embodiment of the subject invention, the mechanical properties of eyes can be adjusted, allowing tissue relaxation and changes in the shape and size of features in the eyes. When the tissue is relaxed, the size and shape of the pressurized channels expand. Persistent relaxation of the mechanical properties of the eyes leads to structural changes in the channels in the eye.

[0026] Moreover, a gauge pressure loading mode that minimizes negative closure effects is preferred over a loading mode that causes channel closure. Structural changes induced by the load recover elastically and quickly once the load is removed. Increasing the viscous component slows recovery, thereby prolonging dilation between wear cycles. The viscous properties of the tissues in the eyes can be enhanced through chemical treatments, medication, or temperature elevation, promoting increased and sustained dilation until the next wear session as shown in Fig. 3.

[0027] The cornea and the sclera comprise viscoelastic collagen and fibrin. The mechanical behavior of viscoelastic material has a time-dependent characteristic that distinguishes its behavior from time-independent elastic materials. When a load is applied onto a viscoelastic structure, the immediate displacement and the residual displacement after the load removal are dependent on the time-dependence relaxation behavior of the viscoelastic materials, as well as on the load, the loading rate, or the load mode.

[0028] A wearable that relaxes the tissue around the fluid channels facilitates sustaining displacement and channel dilation after the load is removed. Loading the channel with gauge pressure load helps drive the opening of the channels. When worn regularly, the corneoscleral tissue elasticity around the Schl emm’s canal is relaxed, and the viscous component is boosted damping the dilation and displacement recovery. The relaxed structure with lower elasticity dilates more, when it is relaxed. The gap between the initial opening size and the dilated state can be further increased by increasing the gauge pressure load during or after warming and vibration. An incubation period is needed before the tissue is fully relaxed. Once the tissue is fully relaxed after an incubation period, recovery of the viscoelastic properties back to the initial state is not immediate. In the post incubation period, the dilation is slow to recover because of higher damping and lower elasticity. The enhanced dilation, that is, a high canal cross-sectional area (CSA) is reached after an incubation wear period. The post-incubation dilation can be maintained with regular wearable wear as shown in Fig. 4.

[0029] Fluid Flow

[0030] Lacrimal puncta: These are small openings in the inner corners of the upper and lower eyelids. Tears flow into the canaliculi, which are tiny channels on the inner eyelid. From there, tears travel into the lacrimal sac. Blinking along with gauge pressure, the balance of internal pressure sac and fluid pressure on the surface of the eye drives the fluid drainage, the mixing with meibum, and the coating of the eye.

[0031] Meibomian glands, on the edges of the eyelids, play a crucial role in maintaining eye health. These tiny glands produce an oily substance called meibum, which combines with other fluids to form tears. The meibomian gland orifice is where meibum is released onto the eyelid margin (Fig. 1). The gauge pressure, the balance of internal pressure in the Meibomian glands, and the fluid pressure on the surface of the eye drives the fluid drainage. The ciliary body produces aqueous humor and secretes the fluid into the posterior chamber. Most of the aqueous humor exits the eye at the angle formed by the junction of the iris and cornea. A smaller amount of aqueous humor drains through the ciliary body face. It enters the uveoscleral pathway, which involves the ciliary muscle and the supraciliary and suprachoroidal spaces. The majority of aqueous humor enters the trabecular meshwork and drains into the Schlemm canal at the corneoscleral junction and flow out of the eye. The gauge pressure, the balance of fluid pressure inside the canal, and fluid pressure on the surface of the eye drives the fluid drainage. The lacrimal gland produces tears.

[0032] The Meibomian gland is on the eyelid. Devices such as Lipidflow sandwiches the eyelids and squeeze the glands from both sides for periods between 10 - 15 minutes to relax and unblock clots. Discomfort during the application is relieved by the clinician using anesthetic in the clinical procedure.

[0033] The fluid drainage channels in the eye, including Schlemm’ s canal, lacrimal sac, the suprachoroidal spaces and the meibomian gland as shown in Fig. 2, are in fluid communication with the eye surface. Only the outer surface of the eye globe is accessible to the outside. Double-sided squeezing on the Schlemm’ s canal, lacrimal sac and the suprachoroidal spaces is not possible without invasion. The body relies on the gauge pressure, comprising of the internal pressure within the channels and the fluid pressure on the surface of the eye, to drain the fluids to the outside. A system that effect changes in the fluid pressure on the surface pressure on the eye can change the gauge pressure in the channels and in the eye globe.

[0034] Further, one method to change fluid pressure change on the eye is to place the head into the pressure-controlled chamber of a helmet. Theoretically, reducing the pressure in the helmet cavity increases the gauge pressure. Testing of the method indicates that the gauge pressure for the drainage of aqueous humor or the intraocular pressure is unchanged and is uncorrelated with the pressure in the sealed helmet.

[0035] Instead of changing the gauge pressure, methods of opening the Schlemm’ s canal through direct contact are provided. Single-sided circular finger massaging motion on the Schlemm’ s canal region through the eyelid were tested. Imaging reveals that the Schlemm’ s canal opens temporarily in some cases but closed in other cases. Channel closure is a negative side effect. Effects such as asymmetric loading from the skin side show that the outcomes are difficult to control and negative side effects are difficult to inhibit. The canal and the eye globe comprise viscoelastic materials. The Schl emm’s canal cross-sectional area (CSA) decreases with age. The decrease is correlated with tissue stiffening, which is associated with age. Relaxing the tissue can help increase the CSA. The compliance may be increased temporarily by warming the eyes, and the channel may be dilated by increasing gauge pressure temporarily. The changes due to the softening and gauge pressurization are lost when the gauge pressure load is removed after the warming.

[0036] MATERIALS AND METHODS

[0037] The effects on sustained tear production are shown in Fig. 5 and the effect of meibum production is shown in Fig. 6. Tear production is enhanced after wear, and the enhancement is effective one hour after wear, indicating that the relaxed dilation is sustained after wear. The tear break-up time shown in Fig. 6 demonstrates that tears are stabilized by the meibum and meibum production is increased after daily use. The results reveal that an incubation period of 3-14 days are needed before steady state mechanical properties in the channel tissue is reached. The rising tear production and the longer TBUT which are indications of rising meibum production. The results confirm that the channel dilation can be maintained when the tissues around these channels are relaxed by regular wear of the wearable after incubation.

[0038] The effects on the drainage of aqueous humor drainage are shown in Fig. 7. While the drainage is improved immediately, sustained improvements as indicated by the drop in the intraocular pressure is observed after an incubation period of up to 8 weeks. Elderly with age- stiffened tissues maybe more responsive than young healthy adults shown in Fig. 7. The IOP drop shows that an incubation period is essential and regular wearable wear is effective in sustaining the dilation in the channels transporting aqueous humor from the eye to the outside.

[0039] The system and methods of the subject invention can be applied to surgical treatments, medications, finger massage, or used independently to modify the tissue properties of the eye. The system and methods can be implemented using variations of a wearable device designed to fit over one or both of a user’s eyes, along with mechanisms to modify the environment, including the hydrostatic pressure within one or more cavities of the wearable.

[0040] Moreover, an outer surface of the wearable can seal against a patient's skin around a perimeter of his / her eye sockets. When the system to alter the environment cyclically is actuated, an environmental change, including cyclical gauge pressure and temperature differential from the external environment and the chemical concentration differential can be created and maintained inside the wearable cavities. The cavity environment is cycled to modify the structural and mechanical properties of the eye. The properties can be relaxed and softened by increasing the chemical concentration of a tissue relaxation medication to relax the tissue and by increasing the temperature of the eye by radiation from a radiation heat source, and by heat conduction through a heat source. Cyclical gauge pressure differential is applied simultaneously with the chemical and thermal profiles or after softening to relax and dilate the eye structure.

[0041] The warming, the vibration, and the medicated mist in the cavity of the wearable relax and soften the eye, increasing its compliance. The cyclical gauge pressure in the cavity enables the relaxed compliant eye tissue to expand and contract.

[0042] According to the embodiments of the subject invention, a wearable method system for modifying properties of eyes based on a low-dose relaxation approach are provided. The method and system integrate vacuum, heat, and light, utilizing low-power OLED technology to deliver a gentle, ultra-safe approach to ocular health and relaxation. The method and system offer several benefits, including the enhancement of choroidal thickness, which supports improved blood flow and oxygen supply to the retina, potentially stabilizing axial elongation. The therapy also promotes better ocular blood circulation, helping to maintain overall eye health while reducing the risk of myopic complications. Moreover, it effectively relieves eye strain and fatigue by relaxing the ciliary muscles, making it particularly useful for individuals who spend extended hours engaged in near work or digital screen use. Designed with safety as a priority, the therapy employs an ultra-low power design, ensuring minimal risk while delivering optimal relaxation benefits.

[0043] The method and system are based on a low-power OLED light source, emitting blended red light within a wavelength range between 600 nm and 700 nm. The power output remains within a safe and controlled range of 0.030 to 0.06 mW, ensuring a gentle and effective therapeutic effect. To enhance the uniformity and intensity of the emitted light, the system may further incorporate a dynamic light diffuser, which can be used with or without a polarizer. When the polarizer is applied, it helps reduce glare and ensures a more uniform light distribution. Without the polarizer, the light is distributed more broadly, accommodating different therapeutic needs. Each therapy session lasts about 30 minutes, allowing sufficient time for the light exposure to take effect. The treatment may be administered twice a day, with a mandatory interval of at least four hours between sessions to inhibit overstimulation. The therapy follows a structured schedule, requiring five sessions per week to achieve optimal results.

[0044] The method and system are carefully designed to maintain a low and safe energy dose. The total energy delivered during each session depends on the power setting. For example, at 0.03 mW, the energy dose amounts to 54 millijoules over a 30-minute (1800-second) session. At 0.06 mW, the dose increases to 108 millijoules over the same duration. These energy levels are deliberately kept low to ensure maximum safety and comfort while still providing effective relaxation and ocular health benefits.

[0045] By integrating precise light modulation with controlled exposure, the method and system offer a non-invasive, safe, and highly effective approach to reduce eye strain, improve ocular circulation, and support long-term eye health.

[0046] In certain embodiments, the system to control and alter the cavity environmental pressure inside the wearable cavities can be a computer-controlled pump with computer- controlled air valves and pressure sensors. The eye temperature system can be temperature sensors and heating sub-systems where the sub-systems may be radiative heating or a conductive heating system. The chemical dispensing system may be a chemical soaked in porous media that vaporizes upon heating or a spray sub-system that fills the cavity with mist, and a camera to monitor the condition of the eye, including its motion and displacement with time.

[0047] In certain embodiments, the power supply for the systems can be a rechargeable or other battery integral to the wearable or wearables. The systems can be actuated, manually or set to follow cycling profile specified by a program in the wearable computer.

[0048] Embodiment 1. A wearable system for modifying properties of eyes, comprising: an ultrasonic device; at least one sealed cavity; a fluid and lighting environment control device; a controller; one or more feedback sensors; and a computing device. Embodiment 2. The system of embodiment 1, wherein the fluid and lighting environment control device is configured to control lighting, liquid or gas.

[0049] Embodiment 3. The system of embodiment 1 or 2, wherein the ultrasonic device is disposed to be in contact with skin around an eye socket.

[0050] Embodiment 4. The system of any preceding embodiment, wherein the ultrasonic device is configured to apply waves of ultrasound to the eye socket and to connective tissues connected to the eye socket.

[0051] Embodiment 5. The system of any preceding embodiment, wherein the fluid and lighting environment control device is configured to sense and control at least one fluid property and one lighting property.

[0052] Embodiment 6. The system of embodiment 5, wherein the fluid property is at least one of fluid gauge pressure, temperature, humidity, or chemical concentration of a fluid in the cavity.

[0053] Embodiment 7. The system of embodiment 6, wherein the fluid and lighting properties that are controlled include light gauges, fluid gauge pressure, temperature, humidity, and chemical concentration of a fluid in the cavity, or any subcombination thereof.

[0054] Embodiment 8. The system of any preceding embodiment, wherein the ultrasonic device and the fluid and lighting environment control device are connected to the computing device to form a sensing-control-feedback unit to maintain a variable environment.

[0055] Embodiment 9. The system of embodiment 6, wherein the fluid and lighting properties are determined and adjusted by the computing device or by a user.

[0056] Embodiment 10. The system of any preceding embodiment, wherein structures in fluid and lighting communication with the wearable cavity are determined and adjusted by the computing device or by a user.

[0057] Embodiment 11. The system of embodiment 10, wherein the structures in fluid and lighting communication with the wearable cavity include eye globe, channels connecting interior of the eye to a surface of the eye, and channels on eyelids for transporting fluid and lighting to the cavity.

[0058] Embodiment 12. A method for modifying properties of eyes, comprising: applying vibrations through actuators in contact with an eye socket bone through skin; warming a cavity to set temperature to a first temperature for a period up to a predetermined time except when the temperature exceeds a second temperature; setting vibration cycles after the set temperature is reached; initiating a cavity pressure cycling after the set temperature is reached and after the setting vibration cycles is completed; and completing the cavity pressure cycling and then completing the warming.

[0059] Embodiment 13. The method of embodiment 12, wherein the first temperature is 50 °C, the predetermined time is 30 minutes, and the second temperature is 42 °C.

[0060] Embodiment 14. The method of embodiment 12 or 13, wherein the actuator is set to vibrate in a range between 0.5 to 4 MHz.

[0061] Embodiment 15. The method of any preceding embodiment, wherein the vibration is set to encompass the eye socket, enabling relaxation of connected appendages and tissues connected to the eye socket.

[0062] Embodiment 16. The method of any preceding embodiment, wherein the cavity pressure cycling is performed in a range between 500 and 900 mmHg and in a period up to 30 minutes.

[0063] Embodiment 17. The method of any preceding embodiment, wherein the cavity pressure cycling comprises initiation cycles, modification cycles, and ending cycles.

[0064] Embodiment 18. The method of embodiment 17, wherein the initiation cycles comprise step-hold pressure cycles in steps of at least 5 mmHg with a period up to 1 minute to set pressure starting in dilation cycles. Embodiment 19. The method of embodiment 17 or 18, wherein the modification cycles comprise at least 5 step-hold negative pressure cycles in steps of 5 mmHg with a period up to 10 minutes with or without leakage.

[0065] Embodiment 20. The method of any of embodiments 17-19, wherein the modification cycles comprise at least 5 step-hold negative and positive pressure cycles in steps of at least 5 mmHg with a period up to 10 minutes with or without leakage.

[0066] Embodiment 21. The method of any of embodiments 17-20, wherein the ending cycles comprise step-hold pressure cycles in steps of at least 5 mmHg with a period up to 1 minute to set negative pressure 2 mmHg below the outside pressure.

[0067] Embodiment 22. The method of any preceding embodiment, further comprising applying a light beam or field to the eye, wherein the light beam or field has a wavelength in a range between 600 nm and 700 nm and at a power level in a range between 0.03 mW and 0.06 mW.

[0068] Embodiment 23. The method of eembodiment 22, further comprising controlling intensity and distribution of the light beam or field by a dynamic light diffuser optionally with a polarizer to achieve desired light intensity and uniformity.

[0069] All patents, patent applications, provisional applications, and publications referred to or cited herein are incorporated by reference in their entirety, including all figures and tables, to the extent they are not inconsistent with the explicit teachings of this specification.

[0070] It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application and the scope of the appended claims. In addition, any elements or limitations of any invention or embodiment thereof disclosed herein can be combined with any and / or all other elements or limitations (individually or in any combination) or any other invention or embodiment thereof disclosed herein, and all such combinations are contemplated with the scope of the invention without limitation thereto.

Claims

CLAIMSWe claim:

1. A wearable system for modifying properties of eyes, comprising: an ultrasonic device; at least one sealed cavity; a fluid and lighting environment control device; a controller; one or more feedback sensors; and a computing device.

2. The system of claim 1, wherein the fluid and lighting environment control device is configured to control lighting, liquid or gas.

3. The system of claim 1, wherein the ultrasonic device is disposed to be in contact with skin around an eye socket.

4. The system of claim 3, wherein the ultrasonic device is configured to apply waves of ultrasound to the eye socket and to connective tissues connected to the eye socket.

5. The system of claim 1, wherein the fluid and lighting environment control device is configured to sense and control at least one fluid property and one lighting property.

6. The system of claim 5, wherein the fluid property is at least one of fluid gauge pressure, temperature, humidity, or chemical concentration of a fluid in the cavity.

7. The system of claim 6, wherein the fluid properties that are controlled include fluid gauge pressure, temperature, humidity, and chemical concentration of a fluid in the cavity, or any subcombination thereof.

8. The system of claim 1, wherein the ultrasonic device and the fluid and lighting environment control device are connected to the computing device to form a sensing-controlfeedback unit to maintain a variable environment.

9. The system of claim 6, wherein the fluid and lighting properties are determined and adjusted by the computing device or by a user.

10. The system of claim 1, wherein structures in fluid and lighting communication with the wearable cavity are determined and adjusted by the computing device or by a user.

11. The system of claim 10, wherein the structures in fluid and lighting communication with the wearable cavity include eye globe, channels connecting interior of the eye to a surface of the eye, and channels on eyelids for transporting fluid to the cavity.

12. A method for modifying properties of eyes, comprising: applying vibrations through actuators in contact with an eye socket bone through skin; warming a cavity to set temperature to a first temperature for a period up to a predetermined time except when the temperature exceeds a second temperature; setting vibration cycles after the set temperature is reached; initiating a cavity pressure cycling after the set temperature is reached and after the setting vibration cycles is completed; and completing the cavity pressure cycling and then completing the warming.

13. The method of claim 12, wherein the first temperature is 50 °C, the predetermined time is 30 minutes, and the second temperature is 42 °C.

14. The method of claim 12, wherein the actuator is set to vibrate in a range between 0.5 to 4 MHz.

15. The method of claim 12, wherein the vibration is set to encompass the eye socket, enabling relaxation of connected appendages and tissues connected to the eye socket.

16. The method of claim 12, wherein the cavity pressure cycling is performed in a range between 500 and 900 mmHg and in a period up to 30 minutes.

17. The method of claim 12, wherein the cavity pressure cycling comprises initiation cycles, modification cycles, and ending cycles.

18. The method of claim 17, wherein the initiation cycles comprise step-hold pressure cycles in steps of at least 5 mmHg with a period up to 1 minute to set pressure starting in dilation cycles.

19. The method of claim 17, wherein the modification cycles comprise at least 5 stephold negative pressure cycles in steps of 5 mmHg with a period up to 10 minutes with or without leakage.

20. The method of claim 17, wherein the modification cycles comprise at least 5 stephold negative and positive pressure cycles in steps of at least 5 mmHg with a period up to 10 minutes with or without leakage.

21. The method of claim 17, wherein the ending cycles comprise step-hold pressure cycles in steps of at least 5 mmHg with a period up to 1 minute to set negative pressure 2 mmHg below the outside pressure.

22. The method of claim 12, further comprising applying a light beam or field to the eye, wherein the light beam or field has a wavelength in a range between 600 nm and 700 nm and at a power level in a range between 0.03 mW and 0.06 mW.

23. The method of claim 22, further comprising controlling intensity and distribution of the light beam or field by a dynamic light diffuser optionally with a polarizer to achieve desired light intensity and uniformity.

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